Man

Leonardo Esteban Valdivia Alvarez

Profesor asistente

Universidad Mayor

Santiago, Chile

Líneas de Investigación


Control génetico del desarrollo del sistema visual e un modelo vertebrado

Educación

  •  Doctorado en Biologia Celular, Molecular y Neurociencias, UNIVERSIDAD DE CHILE. Chile, 2011
  •  Licenciatura en Ciencias con mención en Biología, UNIVERSIDAD DE CHILE. Chile, 2005

Experiencia Académica

  •   Investigador asociado Full Time

    UNIVERSITY COLLEGE LONDON

    Londres, Reino Unido

    2012 - 2017

  •   Profesor asistente Full Time

    UNIVERSIDAD MAYOR

    Ciencias

    Santiago, Chile

    2017 - At present

Experiencia Profesional

  •   Estudiante pregrado Full Time

    Universidad de Chile

    Santiago, Chile

    2001 - 2004

  •   Asistente de investigacion Full Time

    Universidad de Chile

    Santiago, Chile

    2005 - 2006

  •   Estudiante de Doctorado Full Time

    Universidad de Chile

    Santiago, Chile

    2006 - 2011

  •   Postdoctorado (Investigador asociado) Full Time

    University College London

    Londres, Reino Unido

    2012 - 2017

Formación de Capital Humano


Durante mi postdoc en Londres, dirigí 2 tesis de master (Julie Plaisancie y Sydney Leaman) y una de pregrado (Rebecca Wycliffe). En mi laboratorio en Chile, he dirigido 2 tesis de tecnologia medica (Michelle Fernandez y Daniela Cavieres). Hay 2 tesis en curso de la misma carrera (Javiera Robledo y Diego Ramirez) y una tesis casi terminada de biotecnologia (Cristian Sobarzo)


Premios y Distinciones

  •   Premio a la mejor tesis doctoral

    Sociedad Chilena de Biologia Celular

    Chile, 2012

    MI tesis doctoral fue premiada el año 2012


 

Article (19)

Developmental delay during eye morphogenesis underlies optic cup and neurogenesis defects in mab21l2u517 zebrafish mutants

Wycliffe, Rebecca; Plaisancie, Julie; Leaman, Sydney; Santis, Octavia; Tucker, Lisa; Cavieres, Daniela; Fernandez, Michelle; Weiss-Garrido, Camila; Sobarzo, Cristian; Gestri, Gaia; Valdivia, Leonardo E.

Article
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY  (2020)

Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits

Turner, KJ; Hoyle, J; Valdivia, LE; Cerveny, KL; Hart, W; Mangoli, M; Geisler, R; Rees, M; Houart, C; Poole, RJ; Wilson, SW; Gestri, G

Article ISI SCOPUS
PLOS ONE  (2019)

Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits.

Turner, Katherine J; Hoyle, Jacqueline; Valdivia, Leonardo E; Cerveny, Kara L; Hart, Wendy; Mangoli, Maryam; Geisler, Robert; Rees, Michele; Houart, Corinne; Poole, Richard J; Wilson, Stephen W; Gestri, Gaia

Article
PloS one  (2019)

The Oculome Panel Test Next-Generation Sequencing to Diagnose a Diverse Range of Genetic Developmental Eye Disorders

Patel A.; Hayward J.D.; Tailor V.; Nyanhete R.; Ahlfors H.; Gabriel C.; Jannini T.B.; Abbou-Rayyah Y.; Henderson R.; Nischal K.K.; Islam L.; Bitner-Glindzicz M.; Hurst J.; Valdivia, L. E.; Zanolli M.; Moosajee M.; Brookes J.; Papadopoulos M.; Khaw P.T.; Cullup T.; Jenkins L.; Dahlmann-Noor A.; Sowden J.C.

Article ISI SCOPUS
OPHTHALMOLOGY  (2019)

The Oculome Panel Test=> Next-Generation Sequencing to Diagnose a Diverse Range of Genetic Developmental Eye Disorders.

Patel, Aara; Hayward, Jane D; Tailor, Vijay; Nyanhete, Rodney; Ahlfors, Helena; Gabriel, Camila; Jannini, Tommaso B; Abbou-Rayyah, Yassir; Henderson, Robert; Nischal, Ken K; Islam, Lily; Bitner-Glindzicz, Maria; Hurst, Jane; Valdivia, Leonardo E; Zanolli, Mario; Moosajee, Mariya; Brookes, John; Papadopoulos, Maria; Khaw, Peng T; Cullup, Thomas; Jenkins, Lucy; Dahlmann-Noor, Annegret; Sowden, Jane C

Article
Ophthalmology  (2019)

Fishing forward and reverse: Advances in zebrafish phenomics

Fuentes, Ricardo; Letelier, Joaquin; Tajer, Benjamin; Valdivia, Leonardo E.; Mullins, Mary C.

Article ISI SCOPUS
MECHANISMS OF DEVELOPMENT  (2018)

Fishing forward and reverse=> Advances in zebrafish phenomics.

Fuentes, Ricardo; Letelier, Joaquín; Tajer, Benjamin; Valdivia, Leonardo E; Mullins, Mary C

Article
Mechanisms of development  (2018)

Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo.

Krasnow, Anna M; Ford, Marc C; Valdivia, Leonardo E; Wilson, Stephen W; Attwell, David

Article
Nature neuroscience  (2018)

Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish

Valdivia, L. E.; Lamb, D. B.; Horner, W.; Wierzbicki, C.; Tafessu, A.; Williams, A. M.; Gestri, G.; Krasnow, A. M.; Vleeshouwer-Neumann, T. S.; Givens, M.; Young, R. M.; Lawrence, L. M.; Stickney, H. L.; Hawkins, T. A.; Schwarz, Q. P.; Cavodeassi, F.; Wilson, S. W.; Cerveny, K. L.

Article ISI, SCOPUS
Development  (2016)

Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish.

Valdivia, Leonardo E; Lamb, Dayna B; Horner, Wilson; Wierzbicki, Claudia; Tafessu, Amanuel; Williams, Audrey M; Gestri, Gaia; Krasnow, Anna M; Vleeshouwer-Neumann, Terra S; Givens, McKenzie; Young, Rodrigo M; Lawrence, Lisa M; Stickney, Heather L; Hawkins, Thomas A; Schwarz, Quenten P; Cavodeassi, Florencia; Wilson, Stephen W; Cerveny, Kara L

Article
Development (Cambridge, England)  (2016)

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.

Tuschl, Karin; Meyer, Esther; Valdivia, Leonardo E; Zhao, Ningning; Dadswell, Chris; Abdul-Sada, Alaa; Hung, Christina Y; Simpson, Michael A; Chong, W K; Jacques, Thomas S; Woltjer, Randy L; Eaton, Simon; Gregory, Allison; Sanford, Lynn; Kara, Eleanna; Houlden, Henry; Cuno, Stephan M; Prokisch, Holger; Valletta, Lorella; Tiranti, Valeria; Younis, Rasha; Maher, Eamonn R; Spencer, John; Straatman-Iwanowska, Ania; Gissen, Paul; Selim, Laila A M; Pintos-Morell, Guillem; Coroleu-Lletget, Wifredo; Mohammad, Shekeeb S; Yoganathan, Sangeetha; Dale, Russell C; Thomas, Maya; Rihel, Jason; Bodamer, Olaf A; Enns, Caroline A; Hayflick, Susan J; Clayton, Peter T; Mills, Philippa B; Kurian, Manju A; Wilson, Stephen W

Article
Nature communications  (2016)

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism?dystonia

Tuschl, Karin; Meyer, Esther; Valdivia, Leonardo E.; Zhao, Ningning; Dadswell, Chris; Abdul-Sada, Alaa; Hung, Christina Y.; Simpson, Michael A.; Chong, W. K.; Jacques, Thomas S.; Woltjer, Randy L.; Eaton, Simon; Gregory, Allison; Sanford, Lynn; Kara, Eleanna; Houlden, Henry; Cuno, Stephan M.; Prokisch, Holger; Valletta, Lorella; Tiranti, Valeria; Younis, Rasha; Maher, Eamonn R.; Spencer, John; Straatman-Iwanowska, Ania; Gissen, Paul; Selim, Laila A. M.; Pintos-Morell, Guillem; Coroleu-Lletget, Wifredo; Mohammad, Shekeeb S.; Yoganathan, Sangeetha; Dale, Russell C.; Thomas, Maya; Rihel, Jason; Bodamer, Olaf A.; Enns, Caroline A.; Hayflick, Susan J.; Clayton, Peter T.; Mills, Philippa B.; Kurian, Manju A.; Wilson, Stephen W.

Article
NATURE COMMUNICATIONS  (2016)

Watching eyes take shape

Bazin-Lopez, Naiara; Valdivia, Leonardo E; Wilson, Stephen W; Gestri, Gaia

Article
Current Opinion in Genetics and Development  (2015)

Watching eyes take shape.

Bazin-Lopez, Naiara; Valdivia, Leonardo E; Wilson, Stephen W; Gestri, Gaia

Article
Current opinion in genetics & development  (2015)

Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae.

Ceci, Maria Laura; Mardones-Krsulovic, Camila; Sánchez, Mario; Valdivia, Leonardo E; Allende, Miguel L

Article
Neural development  (2014)

In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains

Moro, Enrico; Ozhan-Kizil, Gunes; Mongera, Alessandro; Beis, Dimitris; Wierzbicki, Claudia; Young, Rodrigo M.; Bournele, Despina; Domenichini, Alice; Valdivia, Leonardo E.; Lum, Lawrence; Chen, Chuo; Amatruda, James F.; Tiso, Natascia; Weidinger, Gilbert; Argenton, Francesco

Article SCOPUS
Developmental Biology  (2012)

In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains.

Moro, Enrico; Ozhan-Kizil, Gunes; Mongera, Alessandro; Beis, Dimitris; Wierzbicki, Claudia; Young, Rodrigo M; Bournele, Despina; Domenichini, Alice; Valdivia, Leonardo E; Lum, Lawrence; Chen, Chuo; Amatruda, James F; Tiso, Natascia; Weidinger, Gilbert; Argenton, Francesco

Article
Developmental biology  (2012)

Lef1-dependent Wnt/beta-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development

Valdivia, LE; Young, RM; Hawkins, TA; Stickney, HL; Cavodeassi, F.; Schwarz, Q; Pullin, LM; Villegas, R; Moro E.; Argenton F.; ALLENDE, ML; Wilson, SW

Article ISI SCOPUS
Development (Cambridge)  (2011)

Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development.

Valdivia, Leonardo E; Young, Rodrigo M; Hawkins, Thomas A; Stickney, Heather L; Cavodeassi, Florencia; Schwarz, Quenten; Pullin, Lisa M; Villegas, Rosario; Moro, Enrico; Argenton, Francesco; Allende, Miguel L; Wilson, Stephen W

Article
Development (Cambridge, England)  (2011)

Abstract (2)

Mutation screening and tissue expression patterns implicate SRY-box 14 (SOX14) in human eye and brain developmental anomalies

Holt, RJ; Diaz, DG; Chassaing, N; Valdivia, LE; Wyatt, AW; Plaisancie, J; Bourgeois, D; Vincent-Delorme, C; Osborne, R; Bax, DA; Santos, C; Broadgate, S; Cooper-Charles, L; Allen, LE; McMullan, D; Wilson, SW; Gerrelli, D; Calvas, P; Ragge, NK

Abstract ISI
EUROPEAN JOURNAL OF HUMAN GENETICS  (2019)

Control of cell proliferation and differentiation in the developing and regenerating lateral line system in the zebrafish

ALLENDE, ML; Valdivia L.; Young, R.; Villegas, R; Undurraga C.; Sandoval, P; Gallardo V.; Mardones, C.; Wilson S.

Abstract ISI
DEVELOPMENTAL BIOLOGY  (2010)

Proyecto (5)

CONCURSO NACIONAL DE PROYECTOS APOYO A LA FORMACIÓN DE REDES INTERNACIONALES ENTRE CENTROS DE INVESTIGACIÓN CONVOCATORIA 2018=> A multimodel collaborative network to study development and function of the nervous system in health and disease

CONICYT (REDES180126)

Proyecto
2019-2020
Investigador(a)

Ojo de cebra=> una experiencia educativa e inclusiva a través de la ciencia y el arte

Universidad Mayor (PEP I-2019007)

Proyecto
2019-2020
Director(a)

CONCURSO DE APOYO A LA FORMACIÓN DE REDES INTERNACIONALES PARA INVESTIGADORES(AS) EN ETAPA INICIAL 2017=> Combinación de modelos de pez cebra y Drosophila para resolver la función biológica del gen mab21l2 durante la formación del ojo

CONICYT (REDI170300)

Proyecto
2017-2019
Inv. Principal

GENETIC ANALYSIS OF EYE GROWTH AND THE CAUSES OF MICROPHTHALMIA IN A VERTEBRATE MODEL=> THE ROLE OF MAB21L2

FONDECYT (11160951)

Proyecto
2016-2019
Inv. Responsable

DESARROLLO Y REGENERACION DE CELULAS CILIADAS MECANOSENSORIALES EN LA LINEA LATERAL DEL PEZ CEBRA.

FONDECYT (1070867)

Proyecto
2007-2011
Personal técnico y/o de apoyo

11
Leonardo Valdivia

Profesor asistente

Centro de Biologia Integrativa

Universidad Mayor

Santiago, Chile

3
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Joaquin Letelier

Assistant Professor

Facultad de Ciencias

Universidad Mayor

Santiago, Chile

1
Luis Fuentes

Profesor Asistente

Biologia Celular

Universdad de Concepcion

Concepcion, Chile