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Leonardo Esteban Valdivia Alvarez

Profesor asociado

Universidad Mayor

Santiago, Chile

Control génetico del desarrollo del sistema visual en un modelo vertebrado

Doctorado en Biologia Celular, Molecular y Neurociencias, UNIVERSIDAD DE CHILE. Chile, 2011
Licenciatura en Ciencias con mención en Biología, UNIVERSIDAD DE CHILE. Chile, 2005

Investigador asociado Full Time

UNIVERSITY COLLEGE LONDON

Londres, Reino Unido

2012 - 2017
Profesor asistente Full Time

UNIVERSIDAD MAYOR

Ciencias

Santiago, Chile

2017 - At present
Profesor Asociado Full Time

UNIVERSIDAD MAYOR

CIENCIAS

Santiago, Chile

2022 - At present

Estudiante pregrado Full Time

Universidad de Chile

Santiago, Chile

2001 - 2004
Asistente de investigacion Full Time

Universidad de Chile

Santiago, Chile

2005 - 2006
Estudiante de Doctorado Full Time

Universidad de Chile

Santiago, Chile

2006 - 2011
Postdoctorado (Investigador asociado) Full Time

University College London

Londres, Reino Unido

2012 - 2017

He dirigido multiples tesis de pregrado, 2 de magister, actualmente dirijo 3 de doctorado y superviso a un postdoc ANID.

He liderado iniciativas de divulgación como "ojo de cebra" y "corazón fluorescente"

Premio a la mejor tesis doctoral

Sociedad Chilena de Biologia Celular

Chile, 2012

MI tesis doctoral fue premiada el año 2012

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A Structural Atlas of the Developing Zebrafish Telencephalon Based on Spatially-Restricted Transgene Expression Turner, Katherine J.; Hawkins, Thomas A.; Henriques, Pedro M.; Valdivia, Leonardo E.; Bianco, Isaac H.; Wilson, Stephen W.; Folgueira, Monica Article ISI FRONTIERS IN NEUROANATOMY (2022)
Loss of <i>slc39a14</i> causes simultaneous manganese hypersensitivity and deficiency in zebrafish Tuschl, Karin; White, Richard J.; Trivedi, Chintan; Valdivia, Leonardo E.; Niklaus, Stephanie; Bianco, Isaac H.; Dadswell, Chris; Gonzalez-Mendez, Ramon; Sealy, Ian M.; Neuhauss, Stephan C. F.; et al. Article ISI DISEASE MODELS & MECHANISMS (2022)
Developmental delay during eye morphogenesis underlies optic cup and neurogenesis defects in <i>mab21l2<SUP>u517</SUP></i> zebrafish mutants Wycliffe, Rebecca; Plaisancie, Julie; Leaman, Sydney; Santis, Octavia; Tucker, Lisa; Cavieres, Daniela; Fernandez, Michelle; Weiss-Garrido, Camila; Sobarzo, Cristian; Gestri, Gaia; et al. Article ISI INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2021)
Viral Infection Drives the Regulation of Feeding Behavior Related Genes in Salmo salar San-Martin, Sergio; Tort, Lluis Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Developmental delay during eye morphogenesis underlies optic cup and neurogenesis defects in mab21l2u517 zebrafish mutants Wycliffe, Rebecca; Plaisancie, Julie; Leaman, Sydney; Santis, Octavia; Tucker, Lisa; Cavieres, Daniela; Fernandez, Michelle; Weiss-Garrido, Camila Article INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2020)
Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits Turner, KJ; Hoyle, J; Valdivia, LE; Cerveny, KL; Hart, W; Mangoli, M; Geisler, R; Rees, M; Houart, C; Poole, RJ; et al. Article ISI SCOPUS PLOS ONE (2019)
Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. Turner, Katherine J; Hoyle, Jacqueline; Valdivia, Leonardo E; Cerveny, Kara L; Hart, Wendy; Mangoli, Maryam; Geisler, Robert; Rees, Michele; Houart, Corinne; Poole, Richard J; Wilson, Stephen W; Gestri, Gaia Article PloS one (2019)
The Oculome Panel Test Next-Generation Sequencing to Diagnose a Diverse Range of Genetic Developmental Eye Disorders Hayward J.D.; Tailor V.; Nyanhete R.; Ahlfors H.; Gabriel C.; Jannini T.B.; Abbou-Rayyah Y.; Henderson R.; Nischal K.K.; Islam L.; et al. Article ISI SCOPUS OPHTHALMOLOGY (2019)
The Oculome Panel Test=> Next-Generation Sequencing to Diagnose a Diverse Range of Genetic Developmental Eye Disorders. Patel, Aara; Hayward, Jane D; Tailor, Vijay; Nyanhete, Rodney; Ahlfors, Helena; Gabriel, Camila; Jannini, Tommaso B; Abbou-Rayyah, Yassir; Henderson, Robert; Nischal, Ken K; Islam, Lily; Bitner-Glindzicz, Maria; Hurst, Jane; Valdivia, Leonardo E; Zanolli, Mario; Moosajee, Mariya; Brookes, John; Papadopoulos, Maria; Khaw, Peng T; Cullup, Thomas; Jenkins, Lucy; Dahlmann-Noor, Annegret; Sowden, Jane C Article Ophthalmology (2019)
Fishing forward and reverse: Advances in zebrafish phenomics Letelier, Joaquin; Tajer, Benjamin; Valdivia, Leonardo E.; Mullins, Mary C. Article ISI SCOPUS MECHANISMS OF DEVELOPMENT (2018)
Fishing forward and reverse=> Advances in zebrafish phenomics. Fuentes, Ricardo; Letelier, Joaquín; Tajer, Benjamin; Valdivia, Leonardo E; Mullins, Mary C Article Mechanisms of development (2018)
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Krasnow, Anna M; Ford, Marc C; Valdivia, Leonardo E; Wilson, Stephen W; Attwell, David Article Nature neuroscience (2018)
Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish Article ISI, SCOPUS Development (2016)
Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish. Valdivia, Leonardo E; Lamb, Dayna B; Horner, Wilson; Wierzbicki, Claudia; Tafessu, Amanuel; Williams, Audrey M; Gestri, Gaia; Krasnow, Anna M; Vleeshouwer-Neumann, Terra S; Givens, McKenzie; Young, Rodrigo M; Lawrence, Lisa M; Stickney, Heather L; Hawkins, Thomas A; Schwarz, Quenten P; Cavodeassi, Florencia; Wilson, Stephen W; Cerveny, Kara L Article Development (Cambridge, England) (2016)
Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Tuschl, Karin; Meyer, Esther; Valdivia, Leonardo E; Zhao, Ningning; Dadswell, Chris; Abdul-Sada, Alaa; Hung, Christina Y; Simpson, Michael A; Chong, W K; Jacques, Thomas S; Woltjer, Randy L; Eaton, Simon; Gregory, Allison; Sanford, Lynn; Kara, Eleanna; Houlden, Henry; Cuno, Stephan M; Prokisch, Holger; Valletta, Lorella; Tiranti, Valeria; Younis, Rasha; Maher, Eamonn R; Spencer, John; Straatman-Iwanowska, Ania; Gissen, Paul; Selim, Laila A M; Pintos-Morell, Guillem; Coroleu-Lletget, Wifredo; Mohammad, Shekeeb S; Yoganathan, Sangeetha; Dale, Russell C; Thomas, Maya; Rihel, Jason; Bodamer, Olaf A; Enns, Caroline A; Hayflick, Susan J; Clayton, Peter T; Mills, Philippa B; Kurian, Manju A; Wilson, Stephen W Article Nature communications (2016)
Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism?dystonia Tuschl, Karin; Meyer, Esther; Zhao, Ningning; Dadswell, Chris; Abdul-Sada, Alaa; Hung, Christina Y.; Simpson, Michael A.; Chong, W. K.; Woltjer, Randy L.; Eaton, Simon; et al. Article NATURE COMMUNICATIONS (2016)
Watching eyes take shape Bazin-Lopez, Naiara; Gestri, Gaia Article Current Opinion in Genetics and Development (2015)
Watching eyes take shape. Bazin-Lopez, Naiara; Valdivia, Leonardo E; Wilson, Stephen W; Gestri, Gaia Article Current opinion in genetics & development (2015)
Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae. Ceci, Maria Laura; Mardones-Krsulovic, Camila; Sánchez, Mario; Valdivia, Leonardo E; Allende, Miguel L Article Neural development (2014)
In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains Article SCOPUS Developmental Biology (2012)
In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Moro, Enrico; Ozhan-Kizil, Gunes; Mongera, Alessandro; Beis, Dimitris; Wierzbicki, Claudia; Young, Rodrigo M; Bournele, Despina; Domenichini, Alice; Valdivia, Leonardo E; Lum, Lawrence; Chen, Chuo; Amatruda, James F; Tiso, Natascia; Weidinger, Gilbert; Argenton, Francesco Article Developmental biology (2012)
Lef1-dependent Wnt/beta-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development Valdivia, LE; Young, RM; Hawkins, TA; Stickney, HL; Cavodeassi, F.; Schwarz, Q; Pullin, LM; Villegas, R; Moro E.; Argenton F.; et al. Article ISI SCOPUS Development (Cambridge) (2011)
Lef1-dependent Wnt/Î²-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development. Valdivia, Leonardo E; Young, Rodrigo M; Hawkins, Thomas A; Stickney, Heather L; Cavodeassi, Florencia; Schwarz, Quenten; Pullin, Lisa M; Villegas, Rosario; Moro, Enrico; Argenton, Francesco; Allende, Miguel L; Wilson, Stephen W Article Development (Cambridge, England) (2011)

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Mutation screening and tissue expression patterns implicate SRY-box 14 (SOX14) in human eye and brain developmental anomalies Holt, RJ; Diaz, DG; Chassaing, N; Valdivia, LE; Wyatt, AW; Plaisancie, J; Bourgeois, D; Vincent-Delorme, C; Bax, DA; Broadgate, S; et al. Abstract ISI EUROPEAN JOURNAL OF HUMAN GENETICS (2019)
Control of cell proliferation and differentiation in the developing and regenerating lateral line system in the zebrafish Valdivia L; Young, R.; Villegas, R; Undurraga C.; Sandoval, P; Gallardo V.; Mardones, C.; Wilson S. Abstract ISI DEVELOPMENTAL BIOLOGY (2010)

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Corazon Fluorescente Valdivia, Leonardo; Riveros, María José Proyecto Exposicion de fotografiía científica en la sala de Arte de Temuco de la Universidad Mayor (2023)
CONCURSO NACIONAL DE PROYECTOS APOYO A LA FORMACIÓN DE REDES INTERNACIONALES ENTRE CENTROS DE INVESTIGACIÓN CONVOCATORIA 2018=> A multimodel collaborative network to study development and function of the nervous system in health and disease CONICYT (REDES180126) Proyecto 2019-2020 Investigador(a)
Ojo de cebra=> una experiencia educativa e inclusiva a través de la ciencia y el arte Universidad Mayor (PEP I-2019007) Proyecto 2019-2020 Director(a)
CONCURSO DE APOYO A LA FORMACIÓN DE REDES INTERNACIONALES PARA INVESTIGADORES(AS) EN ETAPA INICIAL 2017=> Combinación de modelos de pez cebra y Drosophila para resolver la función biológica del gen mab21l2 durante la formación del ojo CONICYT (REDI170300) Proyecto 2017-2019 Inv. Principal
GENETIC ANALYSIS OF EYE GROWTH AND THE CAUSES OF MICROPHTHALMIA IN A VERTEBRATE MODEL=> THE ROLE OF MAB21L2 FONDECYT (11160951) Proyecto 2016-2019 Inv. Responsable
DESARROLLO Y REGENERACION DE CELULAS CILIADAS MECANOSENSORIALES EN LA LINEA LATERAL DEL PEZ CEBRA. FONDECYT (1070867) Proyecto 2007-2011 Personal técnico y/o de apoyo


Discovery of novel genetic syndromes in Latin America: Opportunities and challenges Repetto, Gabriela M Review ISI GENETICS AND MOLECULAR BIOLOGY (2024)