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Margarita Calvo Bascuñan

Profesor Asociado

Pontificia Universidad Catolica de Chile

Santiago, Chile

Neuropathic pain; neuropathic itch, RDEB, small fibre neuropathy, skin conditions, epidemiology of pain

Neuroscience, KINGS COLLEGE LONDON. Reino Unido, 2010
Pain Management, KINGS COLLEGE LONDON. Reino Unido, 2009
Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006
Peripheral Nervous system, UNIVERSITA DEGLI STUDI DI MILANO. Italia, 2020

Postdoctoral fellow Full Time

KINGS COLLEGE LONDON

Biomedical school

london-oxford, Reino Unido

2010 - 2013
Profesor Visitante Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Cs Biologicas

santiago, Chile

2013 - 2014
Profesor Asociado Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Cs Biologicas

santiago, Chile

2014 - At present
Profesor Visitante Full Time

UNIVERSITY OF OXFORD

NDCN

Oxford, Reino Unido

2013 - 2014

Postdoctoral fellow Full Time

Kings College London

london, Reino Unido

2010 - 2013
Honorary contract- Clinical researcher Full Time

Kings College London hospitals

London, Reino Unido

2010 - At present
Honorary contract- Clinical researcher Other

Chelsea and Westminster Hospital-Imperial College

London, Reino Unido

2010 - 2013
Visitant Professor Full Time

Oxford University

Oxford, Reino Unido

2013 - At present
Visitant Professor Full Time

Oxford University

Oxford, Reino Unido

2016 - 2016
profesor visitante Full Time

Pontificia Universidad Catolica de Chile

Santiago, Chile

2013 - 2014
Medico acreditado-Unidad del Dolor Other

Red de salud UC Christus

Santiago, Chile

2014 - At present
Profesor Asistente Full Time

Pontificia Universidad Catolica de Chile

Santiago, Chile

2014 - 2019
Early-Career Advisory Group (ECAG) member Other

eLife

Reino Unido

2017 - At present
Management committee Other

Neuropathic Pain Special Interest group (NeuPSIG)

London, Reino Unido

2018 - At present
IASP Councillor Other

International Association for the study of pain

Chile

2020 - At present
Directora Other

Inicitaiva Cinetífico Millennium Nucleus -ANID

Chile

2020 - At present
Visitant Professor Full Time

Oxford University

Oxford, Reino Unido

2023 - 2023
Profesor asociado Full Time

Pontificia Universidad Catolica de Chile

Santiago, Chile

2019 - At present

Dirección De Tesis De Pregrado
- Completa: Daniela Schmidt, Pilar Morales, Alejandra San Martín
- En ejecución: Martina Schenke
- Inmersión en investigación de alumna universidad Los Andes 2014-2015 Sofia von Bischhoffshausen
- Investigación para pregrado verano/invierno :2014 Miguel Calderon,
2015 Renate Reisenegger/ Miguel Calderon,
2017 Sofía Guajardo
2018 Matias Torres Jesús Vega
2019 Daniella Pérez, Francisca Henríquez
2025 Amaro Segura, Francisca Dunner
2026 Amelia Lira, Amaro Segura

Dirección De Tesis De Post-Grado (Solo Doctorado)
Rotación de primer año de doctorado de Néstor Corro 2015
En ejecución, Ariel Tapia y Karin Eger (alumnos de doctorado)
Terminados: Paula Díaz 2024
Macarena Tejos 2024
Zulmary Manjarres 2024
Gustavo Torres 2026
THESIS EXAMINATION
PhD: Victoria Santa María (Universidad Concepción), Guillermo Moya (UC), Mailin Casadei (Universidad Austral,Argentina), Esteban Diaz (UC), Sebastián Castillo (UC), Mailín Casadei (Universidad Austral, Argentina)
MsC: Germán Banner (UC)

Conferencias:
Nacionales
-2018: Sociedad de Neurociencias, Puerto Varas
-2016: XXXVIII Congreso Anual De La Sociedad De Farmacología De Chile. Castro, Chiloé
-2023: ACHED Concepcion III Jornada de Dolor Crónico no Oncológico
-ACHED Congreso Chileno de dolor, Santiago

Internacionales
-2024: IASP World Congress on Pain, Amsterdam
-2023 NeuPSIG Lisbon, Portugal
-2022 ACHED Updates in fibromyalgia
-2022 EFIC 12th Congress of the European Pain Federation, Dublin, Ireland
-2022 IASP World Congress in Pain, Toronto, Canada
-2022 XIX Congreso LASRA Chile 2022 (May)
-2022 IV Jornadas de Dolor Grunenthal
-2021 Chilean Rheumatology society
-2021 Peripheral Nerve Society: Neuropathic Pain symposium
-2021 ACHED
-2021 III Congreso SOLANE (Sociedad latinoamericana de enfermedades neuromusculares)
-2021 Argentinian Society for Neuroscience
-2021 IASP World Congress in Pain (online)
-2021 Comité Internacional de Mujeres en Neuromodulación de la Sociedad Argentina de Neuromodulación (SANE)
-2020 1st EB World Congress, London, UK
- 2019 7th International Congress on Neuropathic Pain (NeuPSIG 2019), London, UK
-2019 eLife Annual Meeting, London, UK
-2018 17th World Congress in Pain IASP. Boston, USA
-2017. Peripheral Nerve Society 2017, Sitges, Spain
-2017. Neuropathic pain Special interest Group IASP, NeuPSIG 2017, Gothenburg, Sweden
-2017 eLife Annual meeting, Boston, USA
-2016. 16th World Congress in Pain IASP. Yokohama, Japan
-2016. Euroconference in Pain, Taormina, Sicily, Italy
-2015. 5to International Congress NeuPSIG. Nice, France
-2015. EFIC IX Pain Congress, Vienna, Austria
-2015. World Congress in neurology, Santiago, Chile
-2015. Chilean Congress in Pain (ACHED). Santiago, Chile
-2014. Satellite symposium in painful neuropathies (NeuPSIG, IASP) Santiago, Chile
-2013. Peripheral Nerve Society Biennial Meeting, St Malo, France
-2012. Joint Italian and British Peripheral Nerve Societies meeting. London, UK
Posters en Congresos Internacionales
- 2016. 16th World Congress in Pain IASP. Yokohama, Japan
- 2015 5th NeuPSIG. Nice, France
- 2015. EFIC IX Pain Congress, Vienna, Austria
- 2014 15th World Congress in Pain IASP. Buenos Aires, Argentina
- 2013 4to Congreso Internacional NeuPSIG. Athens, Greece
- 2012 14th World Congress in Pain IASP. Milan, Italy
- 2010 13th World Congress in Pain IASP. Montreal, Canada
- 2009 Peripheral Nerve Society meeting. Würzburg , Germany
- 2008 12th World Congress in Pain IASP. Glasgow, UK
- 2007. Peripheral Nerve Society,meeting. Snowbird, Utah, USA

Participación En Otras Actividades Asociadas A Investigación.

Revisor de Publicaciones Internacionales (Journal, fecha)
eLife 2018, Glia 2017, Plos NTD 2017, Journal of molecular histology 2017, Neuroscience letters 2017, 2015, 2014, Journal of Pain 2015, Pain Research and Treatment 2015, Pain Medicine 2014, Journal of pain Research 2014 , Biological Research 2014-2018, Revista médica de Chile 2018, Pain 2020-ongoing, Neuroscience letters, Journal of Pain, Pain Research and Treatment, Pain Medicine, Journal of pain Research, Biological Research, Wellcome open access, Frontiers in Pain Research, Journal of the peripheral nervous system, BMJ Open

Revisor de Proyectos Nacionales
Parte del grupo de estudio G1 ANID (fodnecyt regular, de inicio, postdoctorado)
FONDEF 2015, 2019 2020, Becas Chile (doctorado extranjero) 2018-ongoing

Revisor de Proyectos Extranjeros
-Newton Prize 2019-2020 UK National Commission for UNESCO Team.
-The Netherlands Organisation for Scientific Research (NWO/ZonMw) 2016-ongoing
-Italian Ministry of Health (MOH) Riserca Sanitaria 2014-ongoing

PARTICIPATION IN OTHER ACTIVITIES ASSOCIATED WITH RESEARCH
• Council elected IASP 2020-2026 https://www.iasp-pain.org
• Secretary of Neuropathic Pain Consortium (NPC) within the Peripheral Nervous System (PNS) https://www.pnsociety.com/i4a/pages/index.cfm?pageid=3467 2022- ongoing
• Secretary of Neuropathic Pain SIG 2022- ongoing
https://www.iasp-pain.org/SIG/NeuropathicPain
- Co chair Global Year IASP 2025
- Co chair NeuPSIG 2025 Congress, Berlin, Germany
• Member of the nomination committee IASP 2022-2024
• Member of the Scientific program committee for IASP congress 2022 , 2024, 2026
• Member of the Scientific program committee for PNS congress 2023
• Member of the Scientific program committee for NeuPSIG congress 2019, 2023, 2025
• Member of the editorial board of Pain Research Forum: 2018-ongoing
• Member of the editorial board of Revista de Neurología (Viguera) 2020-ongoing
• Member of the editorial board of Journal of pain (U.S. association for the study of pain) 2022-ongoing
• Associate editor of Frontiers in Pain Research 2020-ongoing
• Member of the Early Career Research Advisory Board of the Journal eLife 2017-2019
•

Beca Presidente de la Republica

Gobienro de Chile

Chile, 2007

Beca para estudiar el PhD.
Beca Alban

COMUNIDAD ECONOMICA EUROPEA

Portugal, 2006

Beca Alban para estudios de postgrado en la Comunidad Europea
P.K Thomas Fellowship Award

Peripheral Nerve Society

Estados Unidos, 2009

Mejor presentacion del congreso de PNS
travel grant

UNIVERSITY COLLEGE LONDON

Reino Unido, 2010

TRavel grant
travel grant

KINGS COLLEGE LONDON

Chile, 2009

travel grant
travel grant

IBRO

Estados Unidos, 2010

TRAVEL GRANT
travel grant

IASP

Chile, 2010

International Association for the study of pain travel grant
travel grant

IASP

Chile, 2008

International association for the study of pain travel grant
Travel grant

eLife

Chile, 2017

eLife is a non-profit organisation inspired by research funders and led by scientists. eLife was founded in 2011 by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust, who provide financial support and strategic guidance. They provide a few grants each year to early-stage researchers on eLife papers for funding towards presenting their work at a meeting of their choice.
IASP councilor

International Association for the study of pain

Estados Unidos, 2020

I am an elected councillor for the biggest International society in Pain (IASP). I have been working hard in special interest groups task and in managing the neuPSIG (one of the main SIG of IASP). This year I was selected as one in the " IASP Hall of Champions" (https://www.iasp-pain.org/Membership/Content.aspx?ItemNumber=6221) and then elected to be councillor for 6 years.
Natural and exact sciences Millenium Nucleus

FONDECYT

Chile, 2020

MiNuSPain, milenium nucleus for the study of pain. Adjudicado en concurso 2020 Directora


Impaired skin reinnervation in epidermolysis bullosa due to neurotrophic deficiency Diaz, Paula; Awadelkareem, Mosab Ali; Munoz, Daniela; Espinoza, Fernanda; Clark, Alex J.; Altermatt, Fernando; Veliz, Loreto; Mora, Amaro S.; Nystrom, Alexander; Fuentes, Ignacia; et al. Article ISI PAIN (2026)
Transcriptional-secretory uncoupling in RDEB skin creates a non-permissive microenvironment for sensory nerve regeneration Diaz, Paula; Flores-Munoz, Carolina; Calvo, Margarita Article ISI NEUROBIOLOGY OF PAIN (2026)
Altered Sensory and Stress Responses in Atopic Dermatitis: Effects of Acute Stress on Lesional and Non-Lesional Skin Tejos-Bravo, Macarena; Cid, Dixon; Espinoza, Fernanda; Rojas-Thomas, Felipe; Torres, Gustavo; Cossio, Maria-Laura; Borzutzky, Arturo; Calvo, Margarita Article ISI Experimental Dermatology (2025)
Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies illa S, Aasvang EK, Attal N, Baron R, Bourinet E, Calvo M, Finnerup NB, Galosi E, Hockley JRF, Karlsson P, Kemp H, Körner J, Kutafina E, Lampert A, Mürk M, Nochi Z, Price TJ, Rice ASC, Sommer C, Taba P, Themistocleous AC, Treede RD, Truini A, Üçeyler N, B Article PAIN (2024)
Pregabalin for Neuropathic Pain and Itch in Recessive Dystrophic Epidermolysis Bullosa A Randomized Crossover Trial Calvo, M; Tejos-Bravo M.; Passi-Solar A.; Espinoza F.; Fuentes I.; Lara-Corrales I.; Pope E. Article ISI (2024)
The local molecular signature of human peripheral neuropathic pain Oliver P Sandy-Hindmarch; Pao-Sheng Chang; Paulina S Scheuren; Iara De Schoenmacker; Michèle Hubli; Constantinos Loizou; Stephan Wirth; Devendra Mahadevan; Akira Wiberg; Dominic Furniss; et al. Article (2024)
Chronic pain in Chile: first prevalence report of noncancer chronic pain, fibromyalgia, and neuropathic pain and its associated factors Ferreccio, Catterina Article ISI SCOPUS Pain (2023)
Future perspectives: the next fifty years of the International Association for the Study of Pain Sommer, Claudia; Cervero, Fernando; Loeser, John D. Article ISI SCOPUS Pain (2023)
Lidocaine use in localized thin fiber neuropathy associated with lichen simplex chronicus Sandoval, M; Curi M.; Solis-Avaca, M; Espinoza F.; Almeida P.; Calvo, M Article ISI SCOPUS Revista Medica Clinica Las Condes (2023)
Maintenance of chronicity signatures in fibroblasts isolated from recessive dystrophic epidermolysis bullosa chronic wound dressings under culture conditions Evelyng Catalán; Gabriel Garrido; Pilar Morandé; Jimena Castillo Bennett; Catalina Muñoz; Glenda Cofré; Ya-Lin Huang; Bárbara Cuadra; Paola Murgas; Margarita Calvo; et al. Article ISI SCIELO SCOPUS Biological Research (2023)
Maximizing treatment efficacy through patient stratification in neuropathic pain trials Baron, Ralf; Dickenson, Anthony H.; Dib-Hajj, Sulayman D. Article ISI SCOPUS Nature Reviews Neurology (2023)
Characterisation of the pathophysiology of neuropathy and sensory dysfunction in a mouse model of recessive dystrophic epidermolysis bullosa Schmidt, Daniela; Diaz, Paula; Nystrom, Alexander; Fuentes, Ignacia Article ISI SCOPUS PAIN (2022)
Itch in Lichen Simplex Chronicus Is Associated with Localized Small Fiber Neuropathy Sandoval, Mauricio; Parra, Julio; Rojas-Lechuga, Maria Jesus; Bennett, David L. H. Article ISI SCOPUS JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)
Chronic autoimmune autonomic ganglionopathy. A rare case of dysautonomia Idiáquez Cabezas, J.; Idiaquez Cabezasa, J.; Riquelme Alcázar, J.; Alcazar, J. Riquelme; Casar Leturia, J. C. Article ISI SCOPUS Neurologia (2021)
Studying Independent Kcna6 Knock-out Mice Reveals Toxicity of Exogenous LacZ to Central Nociceptor Terminals and Differential Effects of Kv1.6 on Acute and Neuropathic Pain Sensation Peck, Liam J.; Patel, Ryan; Diaz, Paula; Wintle, Yolanda M.; Todd, Andrew J. Article ISI SCOPUS Journal of Neuroscience (2021)
Ten tips for overcoming language barriers in science Rios Rojas, Clarissa; Boum, Yap, II; Misra, Biswapriya B. Article ISI SCOPUS Nature Human Behaviour (2021)
Metformin protects from oxaliplatin induced peripheral neuropathy in rats Article ISI SCOPUS Neurobiology of Pain (2020)
A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy Pheby T. Article ISI SCOPUS PAIN (2017)
Recessive dystrophic epidermolysis bullosa results in painful small fibre neuropathy Von Bischhoffshausen S.; Schuffeneger V.C. Article ISI SCOPUS BRAIN (2017)
Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury Calvo, M; Richards, N.; Schmid A.B.; Barroso A.; Zhu L.; Ivulic D.; Zhu N.; Anwandter P.; Bhat, M. A.; Court, F. A. Article ISI SCOPUS ELIFE (2016)
Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium Knopp, KL; Stenfors, C; Baastrup, C; Bannon, AW; Caspani, O; Currie, G; Finnerup, N; Kennedy, JD; Machin, I; MacLeod M.; et al. Article ISI SCANDINAVIAN JOURNAL OF PAIN (2015)
A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat Perkins, JR; Antunes-Martins, A; Calvo, M; Grist, J; Rust, W; Schmid R.; Hildebrandt, T; Köhl, M; Orengo, C; McMahon S.B.; et al. Article ISI Molecular Pain (2014)
A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy Huang, WL; Calvo, M; Karu, K; Olausen, HR; Bathgate, G; Okuse, K; Bennett D.L.H.; Rice, ASC Article ISI PAIN (2013)
Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia Gilthorpe Jonathan D; Bennett D.L.H. Article ISI F1000RESEARCH (2013)
CXCL5 Mediates UVB Irradiation-Induced Pain Dawes, JM; Calvo, M; Perkins, JR; Paterson, KJ; Kiesewetter, H; Hobbs, C; Kaan, TKY; Orengo, C; Bennett D.L.H.; McMahon S.B. Article ISI Science Translational Medicine (2011)
Following Nerve Injury Neuregulin-1 Drives Microglial Proliferation and Neuropathic Pain via the MEK/ERK Pathway Calvo, M; Zhu N.; Grist, J; Ma, ZZ; Loeb, JA; Bennett D.L.H. Article ISI GLIA (2011)
Specific involvement of atypical PKC zeta/PKM zeta in spinal persistent nociceptive processing following peripheral inflammation in rat Marchand, F; D'Mello, R; Yip, PK; Calvo, M; Muller E.; Pezet, S; Dickenson A.H.; McMahon S.B. Article ISI Molecular Pain (2011)
Neuregulin-ErbB Signaling Promotes Microglial Proliferation and Chemotaxis Contributing to Microgliosis and Pain after Peripheral Nerve Injury Calvo, M; Zhu N.; Tsantoulas, C; Ma, ZZ; Grist, J; Loeb, JA; Bennett D.L.H. Article ISI JOURNAL OF NEUROSCIENCE (2010)


Microbiota-dependent T-cell response to a-synuclein-derived antigens triggers motor and non-motor symptoms associated to Parkinson's Disease Pacheco, R; Manjarres, Z; Ugalde V.; Prado C.; Chovar O.; Calvo, M Abstract ISI (2024)
EFFECT OF PSYCHOSOCIAL STRESS IN PATIENTS WITH ATOPIC DERMATITIS: RELEVANCE FOR SOMATOSENSORY PROFILE AND SMALL NERVE FIBERS IN CHRONIC LESIONS Tejos-Bravo M.; Cid D.; Alfaro, V; Espinoza F.; Rojas-Thomas, F; Fiedler J.; Calvo, M Abstract ISI ACTA DERMATO-VENEREOLOGICA (2023)
ACUTE STRESS AS A MODULATOR OF SENSORY PERCEPTION: CHANGES IN ITCH, PAIN AND QUANTITATIVE SENSORY TEST Bravo, MT; Cid-Hidalgo, D; Espinoza F.; Rojas-Thomas, F; Fiedler J.; Calvo, M Abstract ISI JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2022)
Contribution of Kv1.6 to modulation of neuropathic pain in vivo and spontaneous activity in vitro Gómez, LG; Muñoz-Silva, D; Espinoza F.; Ugarte G.; Peck L.; Bennett D.; Madrid R.; Calvo, M Abstract ISI (2021)
Lack of skin cell-secreted neurotrophic factors results in a small fiber neuropathy Cespedes, PD; Fuentes I.; Calvo, M Abstract ISI (2021)
Role of Stress Exposure In Itch And Pain: Protocol For a Study in Atopic Dermatitis Tejos-Bravo M.; Rojas-Thomas, F; Espinoza F.; Fiedler J.; Calvo, M Abstract ISI (2021)


Exploring neuroinflammation: A key driver in neuropathic pain disorders Scheuren, Paulina BookReview INTERNATIONAL REVIEW OF NEUROBIOLOGY (2024)


Signals from injured neurons that modulate microglia Bennett DL, Calvo M; Gebhart, Gerald F; Schmidt, Robert F. BookSection (2013)


Dolor Crónico: una ayuda para pacientes Calvo, M; Rivera, S BookWhole (2023)


RETRACTION: Use of lidocaine in localized small fiber neuropathy associated with chronic lichen simplex (Retraction of Vol 34, Pg 109, 2023) Sandoval, M; Curi M.; Solis-Avaca, M; Espinoza F.; Almeidad, P; Calvo, M Generic ISI SCOPUS Revista Medica Clinica Las Condes (2023)


An Immunological Signature of Pain in Fibromyalgia Syndrome. Sikandar, Shafaq Proyecto (2024)
Dolor crónico en la población adulta chilena en edad de trabajar Proyecto Proyectos de Investigación Adjudicados 2023, número 61 (2023)


Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis Soliman, Nadia; Moisset, Xavier; Ferraro, Michael C.; Andrade, Daniel Ciampi de; Baron, Ralf; Belton, Joletta; Bennett, David L. H.; Calvo, Margarita; Dougherty, Patrick; Gilron, Ian; et al. Review ISI LANCET NEUROLOGY (2025)
Regulation of Pain Perception by Microbiota in Parkinson Disease Manjarres, Zulmary; Pacheco, Rodrigo Review ISI (2024)
Acute small fiber neuropathy after Oxford-AstraZeneca ChAdOx1-S vaccination: A report of three cases and review of the literature Abbott, Molly G.; Allawi, Zahra; Hofer, Monika; Ansorge, Olaf; Brady, Stefen; Fadic, Ricardo; Knight, Ravi; Themistocleous, Andreas C. Review ISI SCOPUS JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2022)
The Genetics of Neuropathic Pain from Model Organisms to Clinical Application Davies A.J.; HÃ©bert H.L.; Weir G.A.; Chesler E.J.; Finnerup N.B.; Levitt R.C.; Smith, BH; Neely G.G.; Costigan M. Review ISI SCOPUS NEURON (2019)
The mechanisms of microgliosis and pain following peripheral nerve injury Calvo, M; Bennett D.L.H. Review ISI EXPERIMENTAL NEUROLOGY (2012)
The role of the immune system in the generation of neuropathic pain Calvo, M; Dawes, JM; Bennett D.L.H. Review ISI LANCET NEUROLOGY (2012)