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Marcelo Alejandro Navarrete Signorile

Profesor Titular

Universidad de Magallanes

Punta Arenas, Chile

Bioinformatics Lymphoma biology Tumor genetics and immunology

Medicine, ALBERT-LUDWIGS-UNIVERSITAT FREIBURG. Alemania, 2009
Hematology, UNIVERSIDAD DE BUENOS AIRES. Argentina, 2009
Medico, UNIVERSIDAD NACIONAL DE ROSARIO. Chile, 2002

Researcher Full Time

ALBERT-LUDWIGS-UNIVERSITAT FREIBURG

Medicine

Freiburg, Alemania

2006 - 2009
Postdoc Full Time

ALBERT-LUDWIGS-UNIVERSITAT FREIBURG

Medicine

Freiburg, Alemania

2009 - 2011
Researcher Full Time

LEIDEN UNIVERSITY MEDICAL CENTER

Medicine

Leiden, Holanda

2011 - 2013
Professor Full Time

UNIVERSIDAD DE MAGALLANES

Medicine

Punta Arenas, Chile

2013 - At present

Especialista en Formacion Full Time

Hospital General de Agudos Dr. T. Alvarez

Buenos Aires, Argentina

2002 - 2007
Especialista en Hematologia Other

Clinica Red Salud Magallanes

Punta Arenas, Chile

2014 - At present
Coordinador Laboratorio Covid19 Other

CADI UMAG

Punta Arenas, Chile

2020 - At present

Coordinator of the Immunology course at the School of Medicine, University of Magallanes.
PhD Thesis: Florian Scherer, University of Freiburg, Germany
PhD Thesis: Marvyn Koning, Leiden University, The Netherlands
PhD Thesis: Julieta Sepulveda, Leiden University & University of Magallanes
PhD Thesis: Jorge Gonzalez, University of Magallanes

ASH Merit Award

American Society of Hematology

Estados Unidos, 2011

Merit Award in the context of the ASH conference


Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL Eken, Janneke A.; Koning, Marvyn T.; Kupcova, Kristyna; Yanez, Julieta H. Sepulveda; de Groen, Ruben A. L.; Quinten, Edwin; Janssen, Jurriaan; van Bergen, Cornelis A. M.; Vermaat, Joost S. P.; Cleven, Arjen; Navarrete, Marcelo A.; Ylstra, Bauke; de Jong, Daphne; Havranek, Ondrej; Jumaa, Hassan; Veelken, Hendrik Article ISI JOURNAL OF EXPERIMENTAL MEDICINE (2024)
Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia Quinten, Edwin; Sepulveda-Yanez, Julieta H.; Koning, Marvyn T.; Eken, Janneke A.; Pfeifer, Dietmar; Nteleah, Valeri; de Groen, Ruben A. L.; Saravia, Diego Alvarez; Knijnenburg, Jeroen; Stuivenberg-Bleijswijk, Hedwig E.; Pantic, Milena; Agathangelidis, Andreas; Keppler-Hafkemeyer, Andrea; van Bergen, Cornelis A. M.; Uribe-Paredes, Roberto; Stamatopoulos, Kostas; Vermaat, Joost S. P.; Zirlik, Katja; Navarrete, Marcelo A.; Jumaa, Hassan; Veelken, Hendrik Article ISI HAEMATOLOGICA (2024)
The role of machine learning in health policies during the COVID-19 pandemic and in long COVID management Varon, Lindybeth Sarmiento; Gonzalez-Puelma, Jorge; Medina-Ortiz, David; Aldridge, Jacqueline; Alvarez-Saravia, Diego; Uribe-Paredes, Roberto; Navarrete, Marcelo A. A. Article ISI FRONTIERS IN PUBLIC HEALTH (2023)
Differential neutralizing antibody responses elicited by CoronaVac and BNT162b2 against SARS-CoV-2 Lambda in Chile Acevedo, Monica L.; Gaete-Argel, Aracelly; Alonso-Palomares, Luis; de Oca, Marco Montes; Bustamante, Andres; Gaggero, Aldo; Paredes, Fabio; Cortes, Claudia P.; Pantano, Sergio; Martinez-Valdebenito, Constanza; Angulo, Jenniffer; Le Corre, Nicole; Ferres, Marcela; Navarrete, Marcelo A.; Valiente-Echeverria, Fernando; Soto-Rifo, Ricardo Article ISI NATURE MICROBIOLOGY (2022)
Generalized Property-Based Encoders and Digital Signal Processing Facilitate Predictive Tasks in Protein Engineering Medina-Ortiz, David; Contreras, Sebastian; Amado-Hinojosa, Juan; Torres-Almonacid, Jorge; Asenjo, Juan A.; Navarrete, Marcelo; Olivera-Nappa, Alvaro Article ISI FRONTIERS IN MOLECULAR BIOSCIENCES (2022)
Tandem Substitutions in Somatic Hypermutation Sepulveda-Yanez, Julieta H.; Alvarez Saravia, Diego; Pilzecker, Bas; van Schouwenburg, Pauline A.; van den Burg, Mirjam; Veelken, Hendrik; Navarrete, Marcelo A.; Jacobs, Heinz; Koning, Marvyn T. Article ISI FRONTIERS IN IMMUNOLOGY (2022)
TGF-β/SMAD Pathway Is Modulated by miR-26b-5p: Another Piece in the Puzzle of Chronic Lymphocytic Leukemia Progression Marquez, Maria Elena; Sernbo, Sandra; Payque, Eugenia; Uria, Rita; Tosar, Juan Pablo; Querol, Juliana; Berca, Catalina; Uriepero, Angimar; Prieto, Daniel; Alvarez-Saravia, Diego; Oliver, Carolina; Irigoin, Victoria; Dos Santos, Gimena; Guillermo, Cecilia; Landoni, Ana Inés; Navarrete, Marcelo A.; Palacios, Florencia; Oppezzo, Pablo Article ISI CANCERS (2022)
AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression Oppezzo, Pablo; Navarrete, Marcelo; Chiorazzi, Nicholas Article ISI FRONTIERS IN ONCOLOGY (2021)
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms Morande, Pablo Elias; Yan, Xiao-Jie; Sepulveda, Julieta; Seija, Noe; Marquez, Maria Elena; Sotelo, Natalia; Abreu, Cecilia; Crispo, Martina; Fernandez-Grana, Gabriel; Rego, Natalia; Bois, Therence; Methot, Stephen P.; Palacios, Florencia; Remedi, Victoria; Rai, Kanti R.; Buschiazzo, Alejandro; Di Noia, Javier M.; Navarrete, Marcelo A.; Chiorazzi, Nicholas; Oppezzo, Pablo Article ISI BLOOD (2021)
Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas Sepulveda-Yanez, Julieta H.; Alvarez-Saravia, Diego; Fernandez-Goycoolea, Jose; Aldridge, Jacqueline; van Bergen, Cornelis A. M.; Posthuma, Ward; Uribe-Paredes, Roberto; Veelken, Hendrik; Navarrete, Marcelo A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike's Dynamics Gonzalez-Puelma, Jorge; Aldridge, Jacqueline; Montes de Oca, Marco; Pinto, Monica; Uribe-Paredes, Roberto; Fernandez-Goycoolea, Jose; Alvarez-Saravia, Diego; Alvarez, Hermy; Encina, Gonzalo; Weitzel, Thomas; Munoz, Rodrigo; Olivera-Nappa, Alvaro; Pantano, Sergio; Navarrete, Marcelo A. Article ISI VIRUSES-BASEL (2021)
Peripheral IgE Repertoires of Healthy Donors Carry Moderate Mutation Loads and Do Not Overlap With Other Isotypes Koning M.T.; Trollmann I.J.M.; Van Bergen C.A.M.; Saravia D.A.; Navarrete, M. A.; Kie?basa S.M.; Veelken H. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL Prieto, D; Seija, N; Uriepero, A; Souto-Padron, T; Oliver, C; Irigoin, V; Guillermo, C; Navarrete, MA; Landoni, AI; Dighiero, G; Gabus, R; Giordano M.; Oppezzo, P Article ISI SCOPUS BRITISH JOURNAL OF HAEMATOLOGY (2018)
Physical and psychosocial development of Mapuche and nonindigenous Chilean toddlers: A modest role of ethnicity Navarrete, M. A.; Silva, J. R.; Van Ijzendoorn M.H.; CÃ¡rcamo R.A. Article ISI SCOPUS Development and Psychopathology (2018)
Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response van Bergen, Cornelis A.M.; van Luxemburg-Heijs, Simone A.P.; de Wreede, Liesbeth C.; Eefting, Matthijs; von dem Borne, Peter A.; van Balen, Peter; Heemskerk, Mirjam H.M.; Mulder, Arend; Claas, Fransiscus H.J.; Navarrete, Marcelo A.; Honders, Wilhelmina M.; Rutten, Caroline E.; Veelken, Hendrik; Jedema, Inge; Halkes, Constantijn J.M.; Griffioen, Marieke; Falkenburg, J.H. Frederik Article ISI SCOPUS JOURNAL OF CLINICAL INVESTIGATION (2017)
The pathogenesis of follicular lymphoma, beyond apoptosis resistance Navarrete, Marcelo A.; Oppezzo, Pablo Article ISI SCOPUS TRANSLATIONAL CANCER RESEARCH (2017)
ARTISAN PCR: rapid identification of full-length immunoglobulin rearrangements without primer binding bias. Koning, Marvyn T; Kie?basa, Szymon M; Boersma, Vesna; Buermans, Henk P J; van der Zeeuw, Sander A J; van Bergen, Cornelis A M; Cleven, Arjen H G; Kluin, Philip M; Griffioen, Marieke; Navarrete, Marcelo A; Veelken, Hendrik Article British journal of haematology (2016)
Isotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutation Scherer, F; Navarrete, MA; Bertinetti-Lapatki, C; Boehm J.; Schmitt-Graeff, A; Veelken H. Article ISI SCOPUS Leukemia & lymphoma. (2016)
Selection patterns of B-cell receptors and the natural history of follicular lymphoma Scherer, Florian; van der Burgt, Marlon; Kie?basa, Szymon M.; Bertinetti-Lapatki, Cristina; D?hren von Minden, Marcus; Mikesch, Kristina; Zirlik, Katja; de Wreede, Liesbeth; Veelken, Hendrik; Navarrete, Marcelo A. Article ISI BRITISH JOURNAL OF HAEMATOLOGY (2016)
ELISpot and DC-ELISpot Assay to Measure Frequency of Antigen-Specific IFN gamma-Secreting Cells Navarrete, Marcelo A.; Hnasko, R Article ISI NEISSERIA MENINGITIDIS (2015)
Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation. Papaioannou, Dimitrios; Strothmeyer, Anna-Maria; Dühren-von Minden, Marcus; Keppler-Hafkemeyer, Andrea; Zirlik, Katja; Mikesch, Kristina; van Bergen, Cornelis A M; Navarrete, Marcelo A; Veelken, Hendrik Article Haematologica (2015)
Template-switching anchored polymerase chain reaction reliably amplifies functional lambda light chain transcripts of malignant lymphoma. Koning, Marvyn T; Nteleah, Valeri; Veelken, Hendrik; Navarrete, Marcelo A Article Leukemia & lymphoma (2014)
Usage of standardized antigen-presenting cells improves ELISpot performance for complex protein antigens Navarrete, Marcelo A.; Bertinetti-Lapatki, Cristina; Michelfelder, Ines; Veelken, Hendrik Article ISI JOURNAL OF IMMUNOLOGICAL METHODS (2013)
The use of rituximab therapy in patients with acquired factor v inhibitors Navarrete, M. A.; van der Meer, F. J. M.; Damiani, G.; Diaz, A.; Eikenboom, J. Article ISI AMERICAN JOURNAL OF HEMATOLOGY (2012)
Upfront immunization with autologous recombinant idiotype Fab fragment without prior cytoreduction in indolent B-cell lymphoma Navarrete, Marcelo A.; Heining-Mikesch, Kristina; Schueler, Frank; Bertinetti-Lapatki, Cristina; Ihorst, Gabriele; Keppler-Hafkemeyer, Andrea; Doelken, Gottfried; Veelken, Hendrik Article ISI BLOOD (2011)
Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T cell-mediated immunosurveillance in follicular lymphoma Strothmeyer, Anna-Maria; Papaioannou, Dimitrios; Duehren-von Minden, Marcus; Navarrete, Marcelo; Zirlik, Katja; Heining-Mikesch, Kristina; Veelken, Hendrik Article ISI BLOOD (2010)
Nosology of Malignant Lymphomas - A Modern Pathobiological Approach Navarrete M, Veelken H. Article American Journal of Blood Research (0)


HIGH-THROUGHPUT ANALYSIS OF FULL-LENGTH IMMUNOGLOBULIN TRANSCRIPTS BY TEMPLATE-SWITCHING ANCHORED PCR AND MASSIVE PARALLEL SEQUENCING ON THE PACBIO PLATFORM Koning, MT; Nteleah, V; Navarrete, MA; Veelken H. Abstract ISI HAEMATOLOGICA (2014)
Massive Parallel Sequencing of Full-Length B-Cell Receptor Sequences Reveals HLA-Dependent Shaping of the B-Cell Immune Repertoire Koning, MT; van der Zeeuw, SAJ; Navarrete, M; van Bergen, CAM; Nteleah, V; Griffioen, M; Kielbasa, SM; Veelken H. Abstract ISI BLOOD (2014)


Identification of Immunoglobulin Gene Usage in Immune Repertoires Sequenced by Nanopore Technology Ahumada-García R.; González-Puelma J.; Álvarez-Saravia D.; Barrientos R.J.; Uribe-Paredes R.; López-Cortés X.A.; Navarrete, M. A. ConferencePaper ISI SCOPUS BIO-INSPIRED SYSTEMS AND APPLICATIONS: FROM ROBOTICS TO AMBIENT INTELLIGENCE, PT II (2019)


Acquisition of a glycosylated B-cell receptor drives follicular lymphoma toward a dark zone phenotype van Bergen, Cornelis A. M.; Kloet, Susan L.; Quinten, Edwin; Yanez, Julieta H. Sepulveda; Menafra, Roberta; Griffioen, Marieke; Jansen, Patty M.; Koning, Marvyn T.; Knijnenburg, Jeroen; Navarrete, Marcelo A.; Kielbasa, Szymon M.; Veelken, Hendrik Letter ISI BLOOD ADVANCES (2023)
ARTISAN PCR: rapid identification of full-length immunoglobulin rearrangements without primer binding bias Koning M.T.; Kie?basa S.M.; Boersma V.; Buermans H.P.J.; van der Zeeuw S.A.J.; van Bergen C.A.M.; Cleven A.H.G.; Kluin P.M.; Griffioen M.; Navarrete M.A.; Veelken H. Letter ISI SCOPUS BRITISH JOURNAL OF HAEMATOLOGY (2017)
Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation Papaioannou, D; Strothmeyer, AM; Duhren-von Minden, M; Keppler-Hafkemeyer, A; Zirlik, K; Mikesch, K; van Bergen, CAM; Navarrete, MA; Veelken H. Letter ISI SCOPUS Haematologica (2015)
Template-switching anchored polymerase chain reaction reliably amplifies functional lambda light chain transcripts of malignant lymphoma Koning, MT; Nteleah, V; Veelken H.; Navarrete, MA Letter ISI SCOPUS Leukemia & lymphoma. (2014)


Caracterización funcional de mutaciones con potencial oncogénico inducidas por la enzima AID durante la progresión leucemica Oppezzo, P; Navarrete, M Proyecto (2022)
Computational Oncology: Follicular lymphoma as a model for multidimensional analysis of tumor heterogeneity and subclonal evolution Navarrete, Marcelo; Van Bergen C.A.M. Proyecto (2021)
Tratamiento con Plasma Hiperinmune para Pacientes Críticos con COVID-19 Navarrete, Marcelo A.; Navarrete, Marcelo A.; Rodrigo Muñoz; Monica Pinto A Proyecto (2020)
Assessment of AID-related somatic signatures and their role in tumor progression of class switched vs non-switched B-cell neoplasms Marcelo A Navarrete; Cerda, Mauricio Proyecto (2018)
Oncogenic B-Cell Receptor Signalling in Aggressive B-Cell Lymphomas KWF - The Netherlands (10208) Proyecto 2017-2021 Coinvestigador(a)
ANALYSIS OF IMMUNOGLOBULIN-DERIVED EPITOPES DIVERSIFICATION FOR IMPROVING IDIOTYPE VACCINATION STRATEGIES FONDECYT (11140542) Proyecto 2014-2017 Inv. Responsable
Developing an European American Next Generation Sequencing Network (DEANN) European Commission (http=>//bioinfo.cipf.es/deann/?page_id=36) Proyecto 2014-2017 Coinvestigador(a)
DEVELOPMENT OF A NOVEL TOOL FOR B-CELL RECEPTOR SELECTION PATTERN ANALYSIS IN INDOLENT NON-HODGKIN LYMPHOMAS Universidad de Magallanes (018/DIP-14) Proyecto 2014-2014 Inv. Principal
High-throughput sequencing of the B-cell repertoire. Leiden Genome Technology Center (SASC2013#7) Proyecto 2013-2014 Inv. Principal
RED-IBEROAMERICANA DE LEUCEMIA LINFOIDE CRÓNICA=> HACIA EL DESARROLLO DE NUEVOS MARCADORES PRONÓSTICOS. CYTED (212RT0455) Proyecto 2012-2016 Investigador(a)
Role of B-Cell Receptor in Lymphoma Immunobiology Leiden University Medical Center (VBR 80306) Proyecto 2011-2015 Coinvestigador(a)
Immunotherapy of B-cell Lymphomas DEUTSCHE KREBSHILFE (70-2698-Ve I) Proyecto 2006-2011 Postdoctorado


Mortality in Critically Ill Elderly Individuals Receiving Mechanical Ventilation Santa Cruz R.; Villarejo F.; Figueroa A.; CortÃ©s-JofrÃ© M.; Gagliardi J.; Navarrete M. Review ISI SCOPUS Respiratory Care (2019)