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Nicolás Raúl Dutzan Muñoz

Associate Professor

Universidad de Chile

Santiago, Chile

Oral mucosa immunity and inflammation with a focus in periodontal immunopathology. Th17 cells mechanisms involved in oral mucosa inflammation and periodontal disease.

D.D.S, UNIVERSIDAD DE CHILE. Chile, 2003
Master in Dental Sciences, UNIVERSIDAD DE CHILE. Chile, 2008
PhD Oral and Experimental Pathology, UNIVERSITY OF MARYLAND. Estados Unidos, 2017
Especialista en Periodoncia, UNIVERSIDAD DE CHILE. Chile, 2011

Associate Professor Full Time

UNIVERSIDAD DE CHILE

Dentistry

Santiago, Chile

2007 - At present

Visiting Fellow Other

National Institutes of Health

Bethesda, Estados Unidos

2013 - 2018

Visiting Fellow

NATIONAL INSTITUTES OF HEALTH (NIH)

Estados Unidos, 2013

Research Fellow at the National Institute of Caneofacial and Dental Research, NIH. From 2013 -2018
Becas-Chile

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2013

Beca adjudicada para cursar el programa Ph.D. Oral and experimental pathology en Estados Unidos


A reappraisal of microbiome dysbiosis during experimental periodontitis Arce, Marion; Endo, Natalia; Dutzan, Nicolas; Abusleme, Loreto Article ISI MOLECULAR ORAL MICROBIOLOGY (2022)
Editorial: Immunology of the Oral Mucosa Bergmeier, Lesley Ann; Dutzan, Nicolas; Smith, Patricio C.; Kraan, Heleen Article ISI FRONTIERS IN IMMUNOLOGY (2022)
Aberrant type 1 immunity drives susceptibility to mucosal fungal infections Break, Timothy J.; Oikonomou, Vasileios; Dutzan, Nicolas; Desai, Jigar, V; Swidergall, Marc; Freiwald, Tilo; Chauss, Daniel; Harrison, Oliver J.; Alejo, Julie; Williams, Drake W.; Pittaluga, Stefania; Lee, Chyi-Chia R.; Bouladoux, Nicolas; Swamydas, Muthulekha; Hoffman, Kevin W.; Greenwell-Wild, Teresa; Bruno, Vincent M.; Rosen, Lindsey B.; Lwin, Wint; Renteria, Andy; Pontejo, Sergio M.; Shannon, John P.; Myles, Ian A.; Olbrich, Peter; Ferre, Elise M. N.; Schmitt, Monica; Martin, Daniel; Barber, Daniel L.; Solis, Norma, V; Notarangelo, Luigi D.; Serreze, David, V; Matsumoto, Mitsuru; Hickman, Heather D.; Murphy, Philip M.; Anderson, Mark S.; Lim, Jean K.; Holland, Steven M.; Filler, Scott G.; Afzali, Behdad; Belkaid, Yasmine; Moutsopoulos, Niki M.; Lionakis, Michail S.; Genomics and Computational Biol Co Article ISI SCIENCE (2021)
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier Silva, Lakmali M.; Doyle, Andrew D.; Greenwell-Wild, Teresa; Dutzan, Nicolas; Tran, Collin L.; Abusleme, Loreto; Juang, Lih Jiin; Leung, Jerry; Chun, Elizabeth M.; Lum, Andrew G.; Agler, Cary S.; Zuazo, Carlos E.; Sibree, Megan; Jani, Priyam; Kram, Vardit; Martin, Daniel; Moss, Kevin; Lionakis, Michail S.; Castellino, Francis J.; Kastrup, Christian J.; Flick, Matthew J.; Divaris, Kimon; Bugge, Thomas H.; Moutsopoulos, Niki M. Article ISI SCIENCE (2021)
Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity Williams, Drake Winslow; Greenwell-Wild, Teresa; Brenchley, Laurie; Dutzan, Nicolas; Overmiller, Andrew; Sawaya, Andrew Phillip; Webb, Simone; Martin, Daniel; Hajishengallis, George; Divaris, Kimon; Morasso, Maria; Haniffa, Muzlifah; Moutsopoulos, Niki Maria; NIDCD NIDCR Genomics Computational Article ISI CELL (2021)
Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections" Break, Timothy J.; Oikonomou, Vasileios; Dutzan, Nicolas; Desai, Jigar V.; Swidergall, Marc; Freiwald, Tilo; Chauss, Daniel; Harrison, Oliver J.; Alejo, Julie; Williams, Drake W.; Pittaluga, Stefania; Lee, Chyi-Chia R.; Bouladoux, Nicolas; Swamydas, Muthulekha; Hoffman, Kevin W.; Greenwell-Wild, Teresa; Bruno, Vincent M.; Rosen, Lindsey B.; Lwin, Wint; Renteria, Andy; Pontejo, Sergio M.; Shannon, John P.; Myles, Ian A.; Olbrich, Peter; Ferre, Elise M. N.; Schmitt, Monica; Martin, Daniel; Barber, Daniel L.; Solis, Norma V.; Notarangelo, Luigi D.; Serreze, David V.; Matsumoto, Mitsuru; Hickman, Heather D.; Murphy, Philip M.; Anderson, Mark S.; Lim, Jean K.; Holland, Steven M.; Filler, Scott G.; Afzali, Behdad; Belkaid, Yasmine; Moutsopoulos, Niki M.; Lionakis, Michail S.; Genomics Computational Biol Core Article ISI SCIENCE (2021)
Establishment and Stability of the Murine Oral Microbiome Abusleme, L.; O'Gorman, H.; Dutzan, N.; Greenwell-Wild, T.; Moutsopoulos, N. M. Article ISI JOURNAL OF DENTAL RESEARCH (2020)
A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans Dutzan N.; Kajikawa T.; Abusleme L.; Greenwell-Wild T.; Zuazo C.E.; Ikeuchi T.; Brenchley L.; Abe T.; Hurabielle C.; Martin D.; Morell R.J.; Freeman, A. F.; Lazarevic V.; Trinchieri G.; Diaz P.I.; Holland, S. M.; Belkaid Y.; Hajishengallis G.; Moutsopoulos N.M. Article ISI SCOPUS Science Translational Medicine (2018)
Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1 Moutsopoulos, Niki M.; Zerbe, Christa S.; Wild, Teresa; Dutzan, Nicolas; Brenchley, Laurie; DiPasquale, Giovanni; Uzel, Gulbu; Axelrod, Karen C.; Lisco, Andrea; Notarangelo, Lucia D.; Hajishengallis, George; Notarangelo, Luigi D.; Holland, Steven M. Article ISI NEW ENGLAND JOURNAL OF MEDICINE (2017)
On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier Dutzan, Nicolas; Abusleme, Loreto; Bridgeman, Hayley; Greenwell-Wild, Teresa; Zangerle-Murray, Tamsin; Fife, Mark E.; Bouladoux, Nicolas; Linley, Holly; Brenchley, Laurie; Wemyss, Kelly; Calderon, Gloria; Hong, Bo-Young; Break, Timothy J.; Bowdish, Dawn M. E.; Lionakis, Michail S.; Jones, Simon A.; Trinchieri, Giorgio; Diaz, Patricia I.; Belkaid, Yasmine; Konkel, Joanne E.; Moutsopoulos, Niki M. Article ISI IMMUNITY (2017)
Characterization of the human immune cell network at the gingival barrier Dutzan, N.; Konkel, J. E.; Greenwell-Wild, T.; Moutsopoulos, N. M. Article ISI MUCOSAL IMMUNOLOGY (2016)
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network Dutzan, Nicolas; Abusleme, Loreto; Konkel, Joanne E.; Moutsopoulos, Niki M. Article ISI JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2016)
Changes in lipopolysaccharide profile of Porphyromonas gingivalis clinical isolates correlate with changes in colony morphology and polymyxin B resistance Diaz L.; Hoare, A; Soto C.; Bugueno I.; Silva N.; Dutzan N.; Venegas, D; SALINAS, D; Perez-Donoso J.M.; Gamonal, J; Bravo D. Article ISI SCOPUS ANAEROBE (2015)
Host response mechanisms in periodontal diseases Silva N.; Abusleme L.; Bravo D.; Dutzan N.; Garcia-Sesnich, J; Vernal, R; Hernandez, M.; Gamonal, J Article ISI SCOPUS Journal of Applied Oral Science (2015)
Subgingival Microbial Communities in Leukocyte Adhesion Deficiency and Their Relationship with Local Immunopathology Moutsopoulos, Niki M.; Chalmers, Natalia I.; Barb, Jennifer J.; Abusleme, Loreto; Greenwell-Wild, Teresa; Dutzan, Nicolas; Paster, Bruce J.; Munson, Peter J.; Fine, Daniel H.; Uzel, Gulbu; Holland, Steven M. Article ISI PLOS PATHOGENS (2015)
Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-Driven Inflammatory Bone Loss Moutsopoulos, Niki M.; Konkel, Joanne; Sarmadi, Mojgan; Eskan, Mehmet A.; Wild, Teresa; Dutzan, Nicolas; Abusleme, Loreto; Zenobia, Camille; Hosur, Kavita B.; Abe, Toshiharu; Uzel, Gulbu; Chen, WanJun; Chavakis, Triantafyllos; Holland, Steven M.; Hajishengallis, George Article ISI SCIENCE TRANSLATIONAL MEDICINE (2014)
Interferon-gamma, Interleukins-6 and -4, and Factor XIII-A as Indirect Markers of the Classical and Alternative Macrophage Activation Pathways in Chronic Periodontitis Navarrete, M; García J.; Dutzan N.; Henriquez L.; Puente J.; Carvajal, P; Hernandez, M.; Gamonal, J Article ISI SCOPUS JOURNAL OF PERIODONTOLOGY (2014)
Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells Gonzalez, FE; Ortiz, C.; Reyes, M; Dutzan N.; Patel, V; Pereda, C; GLEISNER, MA; López MN; Gutkind JS; SALAZAR ONFRAY F Article ISI SCOPUS IMMUNOLOGY (2014)
The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation Abusleme L.; Dupuy, AK; Dutzan N.; Silva N.; Burleson, JA; Strausbaugh, LD; Gamonal, J; Diaz, PI Article ISI SCOPUS ISME Journal (2013)
Interleukin-21 Expression and Its Association With Proinflammatory Cytokines in Untreated Chronic Periodontitis Patients Dutzan N.; Vernal, R; Vaqué J.P.; Garcia-Sesnich, J; Hernandez, M.; Abusleme L.; Dezerega, A; Gutkind J.S.; Gamonal, J Article ISI SCOPUS Journal of Periodontology (2012)
Levels of Interleukin-21 in Patients With Untreated Chronic Periodontitis Dutzan N.; Rivas, C; Garcia-Sesnich, J; Henriquez L.; Rivera O.; Dezerega, A; Hernandez, M.; Silva N.; Aguillón JC; Puente J.; Vernal, R; Gamonal, J Article ISI SCOPUS Journal of Periodontology (2011)
Associations Between Matrix Metalloproteinase-8 and -14 and Myeloperoxidase in Gingival Crevicular Fluid From Subjects With Progressive Chronic Periodontitis: A Longitudinal Study Hernandez, M.; Gamonal, J; Tervahartiala, T.; Mantyla, P; Rivera O.; Dezerega, A; Dutzan N.; Sorsa, T. Article ISI SCOPUS Journal of Periodontology (2010)
Chemokine Monocyte Chemoattractant Protein-3 in Progressive Periodontal Lesions in Patients With Chronic Periodontitis Dezerega, A; Pozo, P; Hernandez, M.; Oyarzun A.; Rivera O.; Dutzan N.; Gutierrez-Fernandez, A; Overall, CM; Garrido M.; Alcota, M; Ortiz, E; Gamonal, J Article ISI SCOPUS Journal of Periodontology (2010)
Monocyte chemotactic protein-3: possible involvement in apical periodontitis chemotaxis Dezerega, A; Osorio C.; Mardones, J; Mundi, V; Dutzan N.; Franco, M.; Gamonal, J; Oyarzun A.; Overall, CM; Hernandez, M. Article ISI SCOPUS International Endodontic Journal (2010)
Levels of Interferon-Gamma and Transcription Factor T-Bet in Progressive Periodontal Lesions in Patients With Chronic Periodontitis Dutzan N.; Vernal, R; Hernandez, M.; Dezerega, A; Rivera O.; Silva N.; Aguillón JC; Puente J.; Pozo, P; Gamonal, J Article ISI SCOPUS JOURNAL OF PERIODONTOLOGY (2009)
Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL)-17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis Dutzan N.; Gamonal, J; Silva, A; Sanz, M.; Vernal, R Article ISI SCOPUS JOURNAL OF CLINICAL PERIODONTOLOGY (2009)
Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade Rios, MH; Sorsa, T.; Obregon, F; Tervahartiala, T.; Valenzuela, MA.; Pozo, P; Dutzan N.; Lesaffre E.; Molas, M; Gamonal, J Article ISI SCOPUS JOURNAL OF CLINICAL PERIODONTOLOGY (2009)
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells Silva N.; Dutzan N.; Hernandez, M.; Dezerega, A; Rivera O.; Aguillón JC; Aravena, O; Lastres, P; Pozo, P; Vernal, R; Gamonal, J Article ISI SCOPUS JOURNAL OF CLINICAL PERIODONTOLOGY (2008)
RANKL in human periapical granuloma: possible involvement in periapical bone destruction Vernal, R; Dezerega, A; Dutzan N.; Chaparro, A; Leon, R; Chandia, S; Silva, A; Gamonal, J Article ISI SCOPUS ORAL DISEASES (2006)
Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis Vernal, R; Dutzan N.; Chaparro, A; Puente J.; Valenzuela, MA.; Gamonal, J Article ISI SCOPUS JOURNAL OF CLINICAL PERIODONTOLOGY (2005)


T Helper 17 Cells as Pathogenic Drivers of Periodontitis Dutzan N.; Abusleme L. BookWhole ISI SCOPUS GLIAL CELLS IN HEALTH AND DISEASE OF THE CNS (2019)


UNRAVELING THE ROLE OF JAK1 AND JAK2 PATHWAY IN PERIODONTITIS: DRIVERS OF IMMUNOPATHOLOGY AND POSSIBLE THERAPEUTIC TARGETS Dutzan, Nicolas; Universidad de Chile; Abusleme, Loreto Andrea; Reyes, Montserrat; Arce Paniagua Marion; AGUILLÓN, J. CARLOS Proyecto (2023)
Investigating STAT3 as a driver of pathology and potential therapeutic target in periodontitis Dutzan, Nicolas Proyecto (2018)
BIOLOGICAL PLAQUE CONTROL IN PERIODONTAL DISEASES=> UNDERSTANDING VARIABILITY OF MICROBIOME/IMMUNE RESPONSE AND IMPLEMENTATION OF A CONVENTIONAL PERIODONTAL TREATMENT COMBINED WITH PROBIOTICS. FONDECYT (1130570) Proyecto 2013-2017 Coinvestigador(a)
THE TH17 VS. TREG IMBALANCE IN THE PATHOGENESIS OF PERIODONTITIS=> NEW APPROACH FOR DICHOTOMY TH1 VS. TH2. FONDECYT (1090046) Proyecto 2009-2013 Coinvestigador(a)
CARACTERIZACION MICROBIANA, CELULAR Y MOLECULAR DE LA PROGRESION EN LA PERIODONTITIS CRONICA=>IDENTIFICACION DE MARCADORES DE RIESGO DE DESTRUCCION PERIODONTAL. FONDECYT (1050518) Proyecto 2005-2009 Tesista


Host-Pathogen Interactions in Progressive Chronic Periodontitis Hernandez, M.; Dutzan N.; Garcia-Sesnich, J; Abusleme L.; Dezerega, A; Silva N.; Gonzalez, FE; Vernal, R; Sorsa, T.; Gamonal, J Review ISI SCOPUS JOURNAL OF DENTAL RESEARCH (2011)

Nicolás Dutzan

Associate Professor

Facultad de Odontología

Universidad de Chile

Santiago, Chile

Rolando Vernal

Profesor Titular

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

Jorge Gamonal

Académico

Odontología Conservadora

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

Jorge Gamonal

PROFESOR TITULAR

ODONTOLOGIA CONSERVADORA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Loreto Abusleme

Associate Professor

Oral pathology and medicine

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

Emma Hernandez

Académico 44 h, profesor titular

Oral Patology and Medicine

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

Patricia Pozo

Académico

Ciencias Farmacéuticas

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

Timo Sorsa

Visiting Professor of Oral Biology

Institute of Dentistry

Karolinska Institutet

Stockholm, Suecia

JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Denisse Bravo

Associate Professor

Pathology and Oral Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

Fermín González

Profesor Asociado

Odontología Conservadora

Universidad de Chile

Santiago, Chile

Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Maria Valenzuela

Profesor TItular

Bioquimica y Biología Molecular

Universidad de Chile

Santiagao, Chile

Taina Tervahartiala

Research Scientist

Biomedicum-Institute of Dentistry

Universidad de Helsinki

Helsinki, Finlandia

Paola Carvajal

Profesora Asistente

Odontologia Conservadora

FACULTAD DE ODONTOLOGÍA UNIVERSIDAD DE CHILE

Santiago, Chile

José Pérez

Associate Professor

Biologia

Universidad Andres Bello

Santiago, Chile

Andrés Tittarelli

Profesor Asociado

Instituto Universitario de Investigación y Desarrollo Tecnológico (IDT)

Universidad Tecnológica Metropolitana

Santiago, Chile

Anilei Hoare

Profesora Asistente

Medicina y Patología Oral

Universidad de Chile

SANTIAGO, Chile

María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

Jeannette Mardones

Profesora Adjunta

Odontología Conservadora

Universidad de Chile

Santiago, Chile

sabrita chandia

Profesional de apoyo

Departamento de Educacion en Ciencias de la Salud

Universidad de Chile

Santiago , Chile

OCTAVIO ARAVENA

Gestión I+D

I+D+i

Comisión Chilena de Energía Nuclear

Santiago, Chile

Constanza Osorio

Profesora Asistente

Universidad de Los Andes

Santiago, Chile

Marcela Alcota

Profesora Asistente

Odontologia Conservadora

Universidad de Chile

Santiago, Chile

Montserrat Reyes

Profesor Asistente

Universidad de Chile

Santiago, Chile

Nicolás Raúl Dutzan Muñoz

Líneas de Investigación

Educación

D.D.S, UNIVERSIDAD DE CHILE. Chile, 2003

Master in Dental Sciences, UNIVERSIDAD DE CHILE. Chile, 2008

PhD Oral and Experimental Pathology, UNIVERSITY OF MARYLAND. Estados Unidos, 2017

Especialista en Periodoncia, UNIVERSIDAD DE CHILE. Chile, 2011

Experiencia Académica

Associate Professor Full Time

Experiencia Profesional

Visiting Fellow Other

Premios y Distinciones

Visiting Fellow

Becas-Chile

Article (30)

BookWhole (1)

Proyecto (5)

BIOLOGICAL PLAQUE CONTROL IN PERIODONTAL DISEASES=> UNDERSTANDING VARIABILITY OF MICROBIOME/IMMUNE RESPONSE AND IMPLEMENTATION OF A CONVENTIONAL PERIODONTAL TREATMENT COMBINED WITH PROBIOTICS.

THE TH17 VS. TREG IMBALANCE IN THE PATHOGENESIS OF PERIODONTITIS=> NEW APPROACH FOR DICHOTOMY TH1 VS. TH2.

CARACTERIZACION MICROBIANA, CELULAR Y MOLECULAR DE LA PROGRESION EN LA PERIODONTITIS CRONICA=>IDENTIFICACION DE MARCADORES DE RIESGO DE DESTRUCCION PERIODONTAL.

Review (1)