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Alexandre Iarkov

Assistant professor

Universidad San Sebastián

Concepcion, Chile

*Studies of the neuronal mechanisms of the influence of cotinine on behavioral and neurophysiological aberrations caused by post-traumatic stress disorder (PTSD). *Search for new therapeutic approaches to the treatment of neurodegenerative diseases.

Physiology, MOSCOW STATE UNIVERSITY. Rusia, 1981
Neurophysiology, MOSCOW STATE UNIVERSITY. Rusia, 1994

Post-Doctoral Fellow Full Time

Research Institute of Experimental and Theoretical Biophysics, Pushchino, Moscow Region, Russia

Laboratory of Functional Neurochemistry

Pushchino, Mosow region, Rusia

1994 - 1998
Research Professor Full Time

University of Colima

Colima, México

1998 - 2001
Staff Scientist Full Time

Sun Health Research Institute

Phoenix, Estados Unidos

2001 - 2004
Research Scientist Full Time

Arizona State University

Tempe, Estados Unidos

2004 - 2011
Research Scientist Full Time

Bay Pines VA Healthcare System (VAHCS)

Bay Pines, Estados Unidos

2011 - 2014
Assistant professor Full Time

Universidad San Sebastián

Ciencias de la Salud

Concepcion, Chile

2015 - At present

Research Scientist Full Time

Bay Pines VA Healthcare System (VAHCS)

Bay Pines, FL 33744, Estados Unidos

2012 - 2014
Research Scientist Full Time

Center for Adaptive Neural Systems at the Arizona State University

Tempe, Estados Unidos

2004 - 2011
Staff Scientist Full Time

Thomas H. Christopher Center for Parkinson’s Research, Sun Health Research Institute

Sun City, Estados Unidos

2001 - 2004
Research Professor Full Time

Neuroendocrinology of C.U.I.B. (Centro Universitario de Investigasiones Biomedicas), University of Colima

Colima, México

1998 - 2001
Post-Doctoral Fellow Full Time

Laboratory of Functional Neurochemistry, Institute of Experimental and Theoretical Biophysics, Pushchino, Moscow Region, Russia

Pushchino, Rusia

1994 - 1998
Assistant professor Full Time

Universidad San Sebastián

Concepcion, Chile

2015 - At present


Cotinine enhances fear extinction and astrocyte survival by mechanisms involving the nicotinic acetylcholine receptors signaling Oliveros-Matus, P; Perez-Urrutia, N; Alvarez-Ricartes, N; Echeverria, F; Barreto, G. E.; Elliott, J; Iarkov, A; Echeverria, V Article DOI: 10.3389/fphar.2020.00303 FRONTIERS IN PHARMACOLOGY (2020)
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress Mendoza, Cristhian; Perez-Urrutia, Nelson; Alvarez-Ricartes, Nathalie; Barreto, George E.; Perez-Ordas, Raquel; Iarkov, Alex; Echeverria, Valentina Article ISI FRONTIERS IN NEUROSCIENCE (2018)
Cotinine=> A Therapy for Memory Extinction in Post-traumatic Stress Disorder. Mendoza, Cristhian; Barreto, George E; Iarkov, Alexandre; Tarasov, Vadim V; Aliev, Gjumrakch; Echeverria, Valentina Article Molecular neurobiology (2018)
Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice. Alvarez-Ricartes, Nathalie; Oliveros-Matus, Patricia; Mendoza, Cristhian; Perez-Urrutia, Nelson; Echeverria, Florencia; Iarkov, Alexandre; Barreto, George E; Echeverria, Valentina Article Molecular neurobiology (2018)
Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP plus cells loss induced by restraint stress in mice Perez-Urrutia, Nelson; Mendoza, Cristhian; Alvarez-Ricartes, Nathalie; Oliveros-Matus, Patricia; Echeverria, Florencia; Grizzell, J. Alex; Barreto, George E.; Iarkov, Alexandre; Echeverria, Valentina Article ISI SCOPUS EXPERIMENTAL NEUROLOGY (2017)
Post-treatment with cotinine improved memory and decreased depressive-like behavior after chemotherapy in rats Iarkov, A; Appunn, D; Echeverria, V Article ISI SCOPUS CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease Barreto, G. E.; Iarkov A.; Echeverría Morán, Valentina. Article doi: 10.3389/fnagi.2014.00340 FRONTIERS IN AGING NEUROSCIENCE (2015)
Nicotine-Derived Compounds as Therapeutic Tools Against Post-Traumatic Stress Disorder Barreto, GE; Yarkov, A; Avila-Rodriguez, M; Aliev, G; Echeverria, V Article ISI CURRENT PHARMACEUTICAL DESIGN (2015)
Nicotine-derived compounds as therapeutic tools against post-traumatic stress disorder. E Barreto, G.; Yarkov, A.; Ávila-Rodriguez, M.; Aliev, G.; & Echeverria, V. Article CURRENT PHARMACEUTICAL DESIGN (2015)
Cotinine halts the advance of Alzheimer's disease-like pathology and associated depressive-like behavior in Tg6799 mice Patel S., Grizzell; JA, Holmes; R, Zeitlin; R, Solomon; R, Sutton; TL, Rohani; A, Charry; LC, Iarkov; A, Mori; T., Moran Article Frontiers in Aging Neuroscience (2014)
Cotinine Reduces Depressive-Like Behavior and Hippocampal Vascular Endothelial Growth Factor Downregulation After Forced Swim Stress in Mice Grizzell, JA; Mullins, M; Iarkov, A; Rohani, A; Charry, LC Article Behavioral Neuroscience (2014)
Cotinine reduces depressive-like behavior and hippocampal vascular endothelial growth factor downregulation after forced swim stress in mice. Grizzell, J. A.; Mullins, M.; Iarkov, A.; Rohani, A.; Charry, L. C.; & Echeverria, V. Article BEHAVIORAL NEUROSCIENCE (2014)
Cotinine reduces depressive-like behavior, working memory deficits and synaptic loss associated with chronic stress in mice Grizzell J.A., Iarkov A., Holmes R., Takahashi M., and Echeverria V. Article Behavioural Brain Research (2014)
Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice. Grizzell, J Alex; Iarkov, Alexandre; Holmes, Rosalee; Mori, Takahashi; Echeverria, Valentina Article Behavioural brain research (2014)
Potential Mechanisms Underlying the Facilitation of Fear Memory Extinction by Cotinine Echeverria, Valentina; Iarkov, A Article doi: 10.9734/BJMMR/2014/5219 Journal of Advances in Medicine and Medical Research (2014)
Age-related differences in MK-801 induced behaviors in dopamine D-3 receptor knock out mice Iarkov, Alex V.; Der, Terry C.; Joyce, Jeffrey N. Article ISI EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
Characteristics and Organization of Discharge Properties in Rat Hindlimb Motoneurons Turkin, Vladimir V.; O'Neill, Derek; Jung, Ranu; Iarkov, Alexandre; Hamm, Thomas M. Article ISI JOURNAL OF NEUROPHYSIOLOGY (2010)
Locomotor activity induced by MK-801 is enhanced in dopamine D-3 receptor knockout mice but suppression by dopamine D-3/D-2 antagonists does not occur through the dopamine D-3 receptor Yarkov, Alex V.; Der, Terry C.; Joyce, Jeffrey N. Article ISI EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
Repetetive hindlimb movement using intermittent adaptive neuromuscular electrical stimulation in an incomplete spinal cord injury rodent model Fairchild, Mallika D.; Kim, Seung-Jae; Iarkov, Alex; Abbas, James J.; Jung, Ranu Article ISI EXPERIMENTAL NEUROLOGY (2010)
Adaptive Control of Movement for Neuromuscular Stimulation-Assisted Therapy in a Rodent Model Kim, Seung-Jae; Fairchild, Mallika D.; Iarkov (Yarkov), Alexandre; Abbas, James J.; Jung, Ranu Article ISI IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2009)
Carotid chemoreceptor reflex modulation by arginine-vasopressin microinjected into the nucleus tractus solitarius in rats Adrian Montero, Sergio; Yarkov, Alexander; Lemus, Monica; de Alvarez-Buylla, Elena Roces; Alvarez-Buylla, Ramon Article ISI ARCHIVES OF MEDICAL RESEARCH (2006)
Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D-3 receptor knockout mice Yarkov, AV; Hanger, D; Reploge, M; Joyce, JN Article ISI PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2003)
Arginine-vasopressin in nucleus of the tractus solitarius induces hyperglycemia and brain glucose retention Yarkov, A; Montero, S; Lemus, M; de Alvarez-Buylla, ER; Alvarez-Buylla, R Article ISI BRAIN RESEARCH (2001)
Comparative Analysis of Electrical Brain Activity After GABA and Glutamate Administration: Is It Possible to Have Correlation Between Specific Neurochemical Changes in the Brain and in the EEG? Iarkov, AV; Gal'chenko, VV; Kovalev, GI Article PMID: 9410203 BIULLETEN EKSPERIMENTALNOL BIOLOGII I MEDITSINY (1997)
Changes in the Electrical Activity of the Rat Brain During the Central Administration of Different Doses of GABA Agonists and Antagonists Iarkov AV; Kovalev, GI; Gal'chenko AA Article PMID: 7950791 EKSPERIMENTALNAYA I KLINICHESKAYA FARMAKOLOGIYA
The action of agonists and an antagonist of GABA on the frequency composition of the electrical activity of various brain structures of rats Yarkov AV; Vorob'ev, VV; Kovalev, GI Article DOI: 10.1007/BF01182642 Neurosci Behav Physiol


Chemoreception Montero, SA; Yarkov, A; Lemus, M; Mendoza, H; Valles, V; Alvarez-Buylla E.; Pequignot, J.-M.; Gonzalez, Constancio; Nurse, Colin A.; Prabhakar, NR; Dalmaz, Yvette BookSection (2003)
Carotid chemoreceptors participation in brain glucose regulation. Role of arginine-vasopressin. Montero, SA; Yarkov A; Alvarez-Buylla, R; S. Lahiri et al BookSection doi: 10.1007/0-306-46825-5_75 (2000)


INVESTIGATING COTININE AS A THERAPY FOR POST-TRAUMATIC STRESS DISORDER FONDECYT (1150194) Proyecto 2015-2019 Coinvestigador(a)
Cotinine reduces Chemotherapy-induced Cognitive Impairment Bay Pines Foundation Inc. (9293) Proyecto 2014-2014 Coinvestigador(a)
Memory enhancing effects of high-energy compounds plus cotinine in aged mice Bay Pines Foundation Inc (BPF #2935) Proyecto 2014-2014 Coinvestigador(a)


Strategies for the Treatment of Parkinson’s Disease: Beyond Dopamine Iarkov A.; Barreto G.E.; Grizzell J.A.; Echeverria V. Review ISI SCOPUS (2020)
Positive modulators of the alpha 7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer's disease Echeverria, V; Yarkov, A; Aliev, G Review ISI SCOPUS PROGRESS IN NEUROBIOLOGY (2016)
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson's disease Barreto, GE; Iarkov A.; Moran, VE Review ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2015)

Alexandre Iarkov

Assistant professor

Ciencias de la Salud

Universidad San Sebastián

Concepcion, Chile

George Sampaio

Investigador

Universidad Autónoma de Chile

Santiafo, Chile

Valentina Echeverria

Profesora

Universidad San Sebastian

Concepcion, Chile

CRISTHIAN MENDOZA

Docente Investigador

Facultad de Medicina y Ciencia

Universidad San Sebastián

Concepción, Chile

George Sampaio

Presidente

Colégio Colombiano de Neurociencias

Alexandre Iarkov

Líneas de Investigación

Educación

Physiology, MOSCOW STATE UNIVERSITY. Rusia, 1981

Neurophysiology, MOSCOW STATE UNIVERSITY. Rusia, 1994

Experiencia Académica

Post-Doctoral Fellow Full Time

Research Professor Full Time

Staff Scientist Full Time

Research Scientist Full Time

Research Scientist Full Time

Assistant professor Full Time

Experiencia Profesional

Research Scientist Full Time

Research Scientist Full Time

Staff Scientist Full Time

Research Professor Full Time

Post-Doctoral Fellow Full Time

Assistant professor Full Time

Article (26)

BookSection (2)

Proyecto (3)

INVESTIGATING COTININE AS A THERAPY FOR POST-TRAUMATIC STRESS DISORDER

Cotinine reduces Chemotherapy-induced Cognitive Impairment

Memory enhancing effects of high-energy compounds plus cotinine in aged mice

Review (3)