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Valentina Echeverria Moran

Profesora

Universidad San Sebastian

Concepcion, Chile

Molecular Mechanisms, Drug discovery, Clinical research, Epidemiology, PTSD, schizophrenia, MDD, E Alzheimer disease, Stroke, Aging, Cotinine, Caffeine, antioxidants, Nicotinic acetylcholine receptors, Astrocytes, Ethnopharmacology.

Biología Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 1999
Bioquímica, UNIVERSIDAD DE CONCEPCION. Chile, 1994
Bioquímico, UNIVERSIDAD DE CHILE. Chile, 1991
Clinical research, HARVARD UNIVERSITY. Estados Unidos, 2023

Adjunct Assistant Professor Other

UNIVERSITY OF SOUTH FLORIDA

Medicine

Tampa, Estados Unidos

2007 - 2014
Professor Full Time

Universidad San Sebastian

Ciencias de la Salud

Concepcion, Chile

2015 - 2023
Professor Full Time

Universidad San Sebastian

Medicine

Concepcion, Chile

2023 - At present

Principal Scientist Other

Bay Pines VAHCS

Bay Pines, Estados Unidos

2007 - At present
Research Scientist Full Time

Columbia University

New York, Estados Unidos

2005 - 2006
Postdoctoral fellow Full Time

Johns Hopkins University

Baltimore, Estados Unidos

2003 - 2005
Postdoctoral fellow Full Time

McGill University

Montreal, Canada

2001 - 2003
Cientifico Postdoctoral Full Time

Centro Nacional de Biotecnologia (CNB-CSIC)

España

1999 - 2001

2006-2023
- PhD Thesis
1. Cristhian Mendoza)(2018). Docente Investigador. USS
2. Alex Grizzell) Co-tutor (University of South Florida), Prof. Assistant Professor
3. Rafael Vides, MD, Psychiatrist. 2023. (Universidad de San Carlos de Guatemala
Facultad de Ciencias Médicas. Escuela de Estudios de Postgrado

Master Thesis
- Magister BMENT
1. Ms. Nathalie Alvarez Ricartes TM, MS.(2023). (Lecturer de TM.USS)
2. Ms. Patricia Olivares Matus, TM. Pending. (TM Clinical Laboratory, Pto. Montt)
3. Mr. Nelson Perez Urrutia.TM. Pending. ( Lecturer. USSs)

Master in Biomedicine (University of South Florida) (9 graduates)
4. Sagar Patel. (2014). MD Emergency.
5. Rosalyn Solomon NP(2014). Nurse Practitioner.
6. John Tran J. NP (2014). Nurse
7. Rosaly Holmes (2014).
8. Michelle Mullins M .(2014). (Scientist Florida Department of Law Enforcement-Biology/DNA)
9. Rohani A .(2014). MD.
10. Leila Charry .(2014). MD.

Undergraduate Thesis
- Students of Medical Technology (TM),
1. Carlos Silva Lavin (2016-1)(EB)
2. Nelson Perez Urrutia (2016-2)
3. Patricia Oliveros Matus (2016-2)
4. Francisco Susperreguy Montoya (2018-1)
5. John Hernandez Escanilla (2018-1)
6. Luis Hidalgo (2018-2)
7. Genesis (2018-2)
8. Gloria Cárdenas Véliz (2018-2)
9. Nathalie Diaz Sanhueza (2019-2)
10. Nicolás Ignacio Maldonado Pino (2021-2)
11. Danitza Guzman Fernandez (2021-2)
12. Pablo Toro (2021-2)
13. Miriam Cornejo (2021-2)
14. Nataly Arriasa Leiva (2021-2)
15. Javiera Alvarez (2022-1)
16. Thiare Rosales (2022-1)
17. Alberto Lopez (2023-1)
-Florida State University, 2007
Undergraduate BS-Biology Thesis
18. Sarah Burgess, (). BS. NP. Veterans Affairs Administration.

EDITORIAL BOARDS

American Journal of Alzheimer's Disease and Other Dementias; Journal of Alzheimer's Disease Associate Editor); Frontiers in ethnopharmacology; Neural Regeneration Research; World Journal of Pharmacology, Behavioral sciences; Frontiers in Pharmacology;American Journal of Neurodegenerative Disease; International Neuropsychiatric Disease Journal; Chronic Diseases – International; SM Journal of Depression Research and Treatment; Encyclopedia (Oxford).
Editor (>15 peer-reviewed journals); Ad Hoc Reviewer (33 journals).

Associate Editor Frontiers in Ethnopharmacology; Clinical Neurosciences; Guest Associate Editor: Front in Aging Neuroscience Archive, Neurodegeneration; Molecular Signalling and Pathways; Cellular and Molecular Mechanisms of Brain-aging; Alzheimer's Disease and Related Dementias; Review Editor Front in Aging Neuroscience Archive; Neurotrauma; Cellular and Molecular Mechanisms of Brain-aging; Psychiatry.

Patents

1. US 9,801,865 B2 Materials and methods for diagnosing, preventing, and treating stress disorders and conditions associated with Abeta peptide aggregation. The subject of the invention concerns treating posttraumatic stress disorder. Inventor: Valentina Echeverria Moran (United States of America (USA) Department of Veterans Affairs (VA), University of South Florida (USF), filed Sep. 24, 2009. Approved: October 31, 2017.
2. US 10238641 B2. The subject invention concerns using Cotinine to detect the accumulation of Amyloid beta peptide in neural tissue and diagnose conditions such as AD. The method comprises administering Cotinine labeled with a radioisotope to a person or animal to be detected by Positron Emission Tomography (PET). Filed: October 4, 2017. Date of Patent: March 26, 2019. Assignees: USF, and the USA represented by the VA. Inventor: Valentina Echeverria Moran.
3. US 10, 307,411 B2 The Use of Cotinine in Treating or Preventing Neurogenesis Deficits and Enhancing Neurogenesis. The subject invention concerns methods for preventing neurogenesis deficits in neural tissue in a human or Animal. Inventor:Valentina Echeverria Moran & Doreen Appunn (VA Filed 1/5/2017. Approved; June 4, 2019.
4. US 2020/0000790 A1 The combination of Cotinine plus antioxidants for treatment-resistant depression and correction of astrocytes functional deficit induced by depression and other brain Conditions. Appl. No: 16/486,498 (22). PCT Filed: February 16, 2018 (86) PCT No .: PCT/IB18 / 00306 § 371 (c) (1)(2 Aug. 15, 2019. 16-02-2018. Expiration date:16-02-2038.
5. Chile. 2019-2313, registration: 64.986. Submitted 14-08-2019, Granted 20-05-2022. Date of registration in Chile. 01-08-2022.Uso de cotinina y Aceite de krill para tratar o prevenir un trastorno inducido por estrés crónico, (depresión o ansiedad) y composición farmacéutica que los comprende, Universidad San Sebastián, The USA as represented by the VA. Chile, by the Instituto Nacional de Propiedad Industrial. Santiago, 22 de Agosto de 2022. 9:41:06. Expiration date:16-02-2038.
6. USA-Chile. US Patent No. 63/551,952 titled “Use of Cotinine to Reduce the Ill Effects of Stress in Farmed Sea Animals”. filed February 9, 2024 (VA ID No. 2017-449-06)

Oversea Member

Royal Society of Medicine, UK

Reino Unido, 2018

Elegida como miembro extranjero. Este honor requiere de la postulación por dos miembros secretos de la RSM y la aprobación por un comité de selección.
Doctoral fellowship

CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

Chile, 1995

Four years competitive fellowship to perform the Biological sciences Ph.D. Program at the University of Concepcion, Chile. 1995-1999
Fellowship to participate in the In Vitro Cell Biology and Biotechnology Program

UNIVERSITY OF NEW YORK

Estados Unidos, 1993

Program in cell biology and Biotechnology 700hs,. Graduated with 4.0+/4.0
Teaching Assistant Graduate Fellowship

UNIVERSIDAD DE CONCEPCION

Chile, 1991

Four years Fellowship from the graduate school to perform the Master of Science Program.
International contract

MINISTERIO DE CIENCIA Y TECNOLOGIA

España, 2000

Two years Contract to work in the National Center of Biotechnology, CNB en el laboratorio del Dr. Jose Ramon Naranjo, in Neurobiology. Gene expression regulation by the transcription factor DREAM.
Teaching Assistant Doctoral Fellowship

UNIVERSIDAD DE CONCEPCION

Chile, 1999

One-year fellowship to finish the Ph.D. Program.
Member

American Psychological Association (APA)

Estados Unidos, 2024

Invited to join the American Psychological Association


Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases Echeverria, Valentina; Mendoza, Cristhian; Iarkov, Alex Article ISI FRONTIERS IN NEUROSCIENCE (2023)
Editorial: Improving memory deficits in Alzheimer’s disease Wang F, Braun RJ, Echeverria V and Xu S Article WOS FRONTIERS IN AGING NEUROSCIENCE (2022)
Electronic cigarette use and the risk of cardiovascular diseases Espinoza-Derout J, Shao X M, Lao CJ, Hasan KM, Rivera JC, Jordan MC, Echeverria V, Roos KP, Sinha-Hikim AP, Friedman TC Article WOS FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)
Insights in Ethnopharmacology 2021 Kim CH, Echeverria Moran V, Hohmann, J, Echeverria J, Yen H, Lu A and Michael Heinrich Article WOS FRONTIERS IN PHARMACOLOGY (2022)
Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson's Disease Barreto GE, Gonzalez J, Reiner Ž, Jamialahmadi T, Echeverria V, Ashraf GM, Sahebkar A Article WOS FRONTIERS IN AGING NEUROSCIENCE (2021)
Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause Echeverria V, Echeverria F, Barreto GE, Echeverría J, Mendoza C Article WOS FRONTIERS IN PHARMACOLOGY (2021)
In silico interactions of statins with cell death-inducing DNA. fragmentation factor-like effector A (CIDEA) Barreto GE, Gonzalez J, Reiner Ž, Jamialahmadi T, Echeverria V, Ashraf GM, Sahebkar A Article WOS Chem. Biol. Interact (2021)
Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling. Frontiers in pharmacology Oliveros-Matus, P., Perez-Urrutia, N., Alvarez-Ricartes, N., Echeverria, F., Barreto, G. E., Elliott, J., Iarkov A. & Echeverria, V. Article WOS FRONTIERS IN PHARMACOLOGY (2020)
Editorial: Medicinal Plants for Cardiovascular and Neurodegenerative Aging-Related Diseases: From Bench to Bedside Liu, Y., Echeverria, V., & Xu, Y. Article WOS FRONTIERS IN PHARMACOLOGY (2020)
(E)-Nicotinaldehyde O-Cinnamyloxime, a Nicotine Analog, Attenuates Neuronal Cells Death Against Rotenone-Induced Neurotoxicity Jurado-Coronel, JC; Loaiza, AE; Diaz, JE; Cabezas, R; Ashraf, GM; Sahebkar, A; Echeverria, V; Gonzalez, J; Barreto, GE Article Molecular Neurobiology (2019)
Astrocytes Mediate Protective Actions of Estrogenic Compounds after Traumatic Brain Injury Martin-Jiménez C, Gaitán-Vaca DM, Areiza N, Echeverria V, Ashraf GM, González J, Sahebkar A, Garcia-Segura LM, Barreto GE Article ISI SCOPUS NEUROENDOCRINOLOGY (2019)
Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells Baez-Jurado, E.; Rincon-Benavides, M. A.; Hidalgo-Lanussa, O.; Guio-Vega, G.; Ashraf, G. M.; Sahebkar, A.; Echeverria, V.; Garcia-Segura, L. M.; Barreto, G. E. Article ISI SCOPUS FRONTIERS IN NEUROENDOCRINOLOGY (2019)
Raloxifene attenuates oxidative stress and preserves mitochondrial function in astrocytic cells upon glucose deprivation Vesga-Jimenez, Diego J.; Hidalgo-Lanussa, Oscar; Baez-Jurado, Eliana; Echeverria, Valentina; Ashraf, Ghulam Md; Sahebkar, Amirhossein; Barreto, George E. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Tibolone attenuates inflammatory response by palmitic acid and preserves mitochondrial membrane potential in astrocytic cells through estrogen receptor beta Gonzalez-Giraldo, Y; Forero, DA; Echeverria, V; Garcia-Segura, LM; Barreto, GE Article Molecular and Cellular Endocrinology (2019)
Tibolone attenuates inflammatory response by palmitic acid and preserves mitochondrial membrane potential in astrocytic cells through estrogen receptor beta. González-Giraldo Y, Forero DA, Echeverria V, Garcia-Segura LM, Barreto GE Article WOS Mol Cell Endocrinol (2019)
Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay Baez-Jurado, E; Vega, GG; Aliev, G; Tarasov, VV; Esquinas, P; Echeverria, V; Barreto, GE Article Molecular Neurobiology (2018)
Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay. Baez-Jurado, Eliana; Vega, Gina Guio; Aliev, Gjumrakch; Tarasov, Vadim V; Esquinas, Paula; Echeverria, Valentina; Barreto, George E Article Molecular neurobiology (2018)
Conditioned Medium of Human Adipose Mesenchymal Stem Cells Increases Wound Closure and Protects Human Astrocytes Following Scratch Assay In Vitro Baez-Jurado, E; Hidalgo-Lanussa, O; Guio-Vega, G; Ashraf, GM; Echeverria, V; Aliev, G; Barreto, GE Article Molecular Neurobiology (2018)
Conditioned Medium of Human Adipose Mesenchymal Stem Cells Increases Wound Closure and Protects Human Astrocytes Following Scratch Assay In Vitro. Baez-Jurado, Eliana; Hidalgo-Lanussa, Oscar; Guio-Vega, Gina; Ashraf, Ghulam Md; Echeverria, Valentina; Aliev, Gjumrakch; Barreto, George E Article Molecular neurobiology (2018)
Correction to=> Cotinine=> A Therapy for Memory Extinction in Post-traumatic Stress Disorder. Mendoza, Cristhian; Barreto, George E; Iarkov, Alexandre; Tarasov, Vadim V; Aliev, Gjumrakch; Echeverria, Valentina Article Molecular neurobiology (2018)
Correction to=> Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress. Cabezas, Ricardo; Baez-Jurado, Eliana; Hidalgo-Lanussa, Oscar; Echeverria, Valentina; Ashraf, Ghulam Md; Sahebkar, Amirhossein; Barreto, George E Article Molecular neurobiology (2018)
Correction to=> Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice. Alvarez-Ricartes, Nathalie; Oliveros-Matus, Patricia; Mendoza, Cristhian; Perez-Urrutia, Nelson; Echeverria, Florencia; Iarkov, Alexandre; Barreto, George E; Echeverria, Valentina Article Molecular neurobiology (2018)
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress Mendoza, Cristhian; Perez-Urrutia, Nelson; Alvarez-Ricartes, Nathalie; Barreto, George E.; Perez-Ordas, Raquel; Iarkov, Alex; Echeverria, Valentina Article ISI FRONTIERS IN NEUROSCIENCE (2018)
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress. Mendoza C, Perez-Urrutia N, Alvarez-Ricartes N, Barreto GE, Pérez-Ordás R, Iarkov A, Echeverria V Article WOS FRONTIERS IN NEUROSCIENCE (2018)
Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder Mendoza, Cristhian; Barreto, George E.; Iarkov, Alexandre; Tarasov, Vadim V.; Aliev, Gjumrakch; Echeverria, Valentina Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2018)
Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone Areiza-Mazo, N; Robles, J; Zamudio-Rodriguez, JA; Giraldez, L; Echeverria, V; Barrera-Bailon, B; Aliev, G; Sahebkar, A.; Ashraf, GM; Barreto, GE Article ISI SCOPUS FRONTIERS IN CHEMISTRY (2018)
Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress. Cabezas R, Baez-Jurado E, Hidalgo-Lanussa O, Echeverria V, Ashrad GM, Sahebkar A, Barreto GE Article WOS MOLECULAR NEUROBIOLOGY (2018)
Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress. Cabezas, Ricardo; Baez-Jurado, Eliana; Hidalgo-Lanussa, Oscar; Echeverria, Valentina; Ashrad, Ghulam Md; Sahebkar, Amirhossein; Barreto, George E Article Molecular neurobiology (2018)
Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases Ashraf, JM; Ansari, MA; Fatma, S; Abdulla, SMS; Iqbal, J; Madkhali, A; Hamali, A; Ahmad, S.; Jerah, A; Echeverria, V; Barreto, GE; Ashraf, GM Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2018)
Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice Alvarez-Ricartes, Nathalie; Oliveros-Matus, Patricia; Mendoza, Cristhian; Perez-Urrutia, Nelson; Echeverria, Florencia; Iarkov, Alexandre; Barreto, George E.; Echeverria, Valentina Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2018)
Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury Baez-Jurado E.; Guio-Vega G.; Hidalgo-Lanussa O.; GonzÃ¡lez J.; Echeverria V.; Ashraf G.M.; Sahebkar A.; Barreto G.E. Article SCOPUS Molecular Neurobiology (2018)
PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult Cabezas, R; Vega-Vela, NE; Gonzalez-Sanmiguel, J; Gonzalez, J; Esquinas, P; Echeverria, V; Barreto, GE Article Molecular Neurobiology (2018)
PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult. Cabezas, Ricardo; Vega-Vela, Nelson E; González-Sanmiguel, Juliana; González, Janneth; Esquinas, Paula; Echeverria, Valentina; Barreto, George E Article Molecular neurobiology (2018)
Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid Gonzalez-Giraldo, Y; Garcia-Segura, LM; Echeverria, V; Barreto, GE Article Molecular Neurobiology (2018)
Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid. González-Giraldo, Yeimy; Garcia-Segura, Luis Miguel; Echeverria, Valentina; Barreto, George E Article Molecular neurobiology (2018)
Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta Hidalgo-Lanussa, O; Avila-Rodriguez, M; Baez-Jurado, E; Zamudio, J; Echeverria, V; Garcia-Segura, LM; Barreto, GE Article Molecular Neurobiology (2018)
Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta. Hidalgo-Lanussa, Oscar; Ávila-Rodriguez, Marco; Baez-Jurado, Eliana; Zamudio, Jairo; Echeverria, Valentina; Garcia-Segura, Luis Miguel; Barreto, George E Article Molecular neurobiology (2018)
4'-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation. Baez, Eliana; Guio-Vega, Gina Paola; Echeverria, Valentina; Sandoval-Rueda, Daniel Andres; Barreto, George E Article Neurotoxicity research (2017)
4?-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation Baez E., Guio-Vega G.P.; Echeverria V., Sandoval-Rueda D.A. Article Neurotoxicity Research (2017)
Advances in Medicinal Plants with Effects on Anxiety Behavior Associated to Mental and Health Conditions Barreto GE, Avila-Rodriguez M; Foitzick M, Aliev G Article CURRENT MEDICINAL CHEMISTRY (2017)
Advances in Medicinal Plants with Effects on Anxiety Behavior Associated to Mental and Health Conditions. Barreto, George E; Avila-Rodriguez, Marco; Foitzick, Madeline; Aliev, Gjumrakch; Echeverria, Valentina Article Current medicinal chemistry (2017)
Approaches of the transcriptomic analysis in astrocytes: Potential pharmacological targets. Barreto, George E; Gómez, Rosa M; Bustos, Rosa Helena; Forero, Diego A; Aliev, Gjumrakch; Leszek, Jerzy; Echeverria, Valentina; Gonzalez, Janneth Article Current pharmaceutical design (2017)
Approaches of the transcriptomic analysis in astrocytes=> Potential pharmacological targets. Barreto, George E; Gómez, Rosa M; Bustos, Rosa Helena; Forero, Diego A; Aliev, Gjumrakch; Leszek, Jerzy; Echeverria, Valentina; Gonzalez, Janneth Article Current pharmaceutical design (2017)
Astrocytes and endoplasmic reticulum stress=> A bridge between obesity and neurodegenerative diseases. Martin-Jiménez, Cynthia A; García-Vega, Ángela; Cabezas, Ricardo; Aliev, Gjumrakch; Echeverria, Valentina; González, Janneth; Barreto, George E Article Progress in neurobiology (2017)
Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay. Baez-Jurado, Eliana; Vega, Gina Guio; Aliev, Gjumrakch; Tarasov, Vadim V; Esquinas, Paula; Echeverria, Valentina; Barreto, George E Article Molecular neurobiology (2017)
Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice. Grizzell, J Alex; Patel, Sagar; Barreto, George E; Echeverria, Valentina Article Progress in neuro-psychopharmacology & biological psychiatry (2017)
Ginkgo biloba as an Alternative Medicine in the Treatment of Anxiety in Dementia and other Psychiatric Disorders. Singh, Sandeep Kumar; Barreto, George E; Aliev, Gjumrakch; Echeverria, Valentina Article Current drug metabolism (2017)
Gliomas=> New Perspectives in Diagnosis, Treatment and Prognosis. Ghotme, Kemel A; Barreto, George E; Echeverria, Valentina; Gonzalez, Janneth; Bustos, Rosa H; Sanchez, Magdy; Leszek, Jerzy; Yarla, Nagendra Sastry; Gomez, Rosa Margarita; Tarasov, Vadim V; Ashraf, Ghulam Md; Aliev, Gjumrakch Article Current topics in medicinal chemistry (2017)
Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP+ cells loss induced by restraint stress in mice. Perez-Urrutia, Nelson; Mendoza, Cristhian; Alvarez-Ricartes, Nathalie; Oliveros-Matus, Patricia; Echeverria, Florencia; Grizzell, J Alex; Barreto, George E; Iarkov, Alexandre; Echeverria, Valentina Article EXPERIMENTAL NEUROLOGY (2017)
Is VEGF a key target of cotinine and other potential therapies against Alzheimer disease? Echeverria V, Barreto GE; Ávila-Rodriguez M, Tarasov VV Article Current Alzheimer Research (2017)
Is VEGF a Key Target of Cotinine and Other Potential Therapies Against Alzheimer Disease? Echeverria, Valentina; Barreto, George E; Avila-Rodriguezc, Marco; Tarasov, Vadim V; Aliev, Gjumrakch Article Current Alzheimer research (2017)
Is VEGF a key target of cotinine and other potential therapies against Alzheimer disease? Echeverria, Valentin; Barreto, George E; Ávila-Rodriguez, Marco; Tarasov, Vadim V; Aliev, Gjumrakch Article Current Alzheimer research (2017)
Medicinal plants as protective strategies against Parkinson's Disease. Mazo, Natalia Areiza; Echeverria, Valentina; Cabezas, Ricardo; Ávila-Rodriguez, Marco; Aliev, Gjumrakch; Leszek, Jerzy; Barreto, George E Article Current pharmaceutical design (2017)
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment Bachurin S.O., Shevtsova E.F.; Makhaeva G.F., Grigoriev V.V.; Boltneva N.P., Kovaleva N.V.; Lushchekina S.V., Shevtsov P.N.; Neganova M.E., Redkozubova O.M.; Bovina E.V., Gabrelyan A.V.; Fisenko V.P., Sokolov V.B.; Aksinenko A.Y., Echeverria V.; Barreto G.E., Aliev G. Article SCIENTIFIC REPORTS (2017)
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment Bachurin S.O., Shevtsova E.F.; Makhaeva G.F., Grigoriev V.V.; Boltneva N.P., Kovaleva N.V.; Lushchekina S.V., Shevtsov P.N.; Neganova M.E., Redkozubova O.M.; Bovina E.V., Gabrelyan A.V.; Fisenko V.P., Sokolov V.B.; Aksinenko A.Y., Echeverria V.; Barreto G.E., Aliev G. Article Scientific Reports (2017)
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment. Bachurin, Sergey O; Shevtsova, Elena F; Makhaeva, Galina F; Grigoriev, Vladimir V; Boltneva, Natalia P; Kovaleva, Nadezhda V; Lushchekina, Sofya V; Shevtsov, Pavel N; Neganova, Margarita E; Redkozubova, Olga M; Bovina, Elena V; Gabrelyan, Alexey V; Fisenko, Vladimir P; Sokolov, Vladimir B; Aksinenko, Alexey Yu; Echeverria, Valentina; Barreto, George E; Aliev, Gjumrakch Article Scientific reports (2017)
PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult. Cabezas, Ricardo; Vega-Vela, Nelson E; González-Sanmiguel, Juliana; González, Janneth; Esquinas, Paula; Echeverria, Valentina; Barreto, George E Article Molecular neurobiology (2017)
RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration. G?siorowski, Kazimierz; Brokos, Barbara; Echeverria, Valentina; Barreto, George E; Leszek, Jerzy Article Molecular neurobiology (2017)
Ginkgo biloba as an alternative medicine in the treatment of anxiety in dementia and other psychiatric disorders Singh SK, Barreto GE; Aliev G, Echeverria V. Article CURRENT DRUG METABOLISM (2016)
Growth Factors and Astrocytic Metabolism: Possible Roles for Platelet Derived Growth Factor. Cabezas R, Avila MF, Vega-Vela NE, Echeverria MV, González J, Hidalgo OA, Brito-Santos A, Barreto GE. Article Medicinal Chemistry (2016)
Implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease Jurado-Coronel, JC; Avila-Rodriguez, M; Echeverria, V; Hidalgo, OA; González, J; Aliev, G; Barreto, GE Article CNS NEUROLOGICAL DISORDERS-DRUG TARGETS (2016)
Implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease. Jurado-Coronel JC, Ávila-Rodriguez M, Echeverria V, Hidalgo OA, Gonzalez J, Aliev G and Barreto GE Article CNS & Neurological Disorders - Drug Targets, (2016)
Implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease. Jurado-Coronel, Juan C; Ávila-Rodriguez, Marco; Echeverria, Valentina; Hidalgo, Oscar Alejandro; Gonzalez, Janneth; Aliev, Gjumrakch; Barreto, George E Article CNS & neurological disorders drug targets (2016)
L-Type Calcium Channels Modulation by Estradiol. Vega-Vela, Nelson E; Osorio, Daniel; Avila-Rodriguez, Marco; Gonzalez, Janneth; García-Segura, Luis Miguel; Echeverria, Valentina; Barreto, George E Article Molecular neurobiology (2016)
Microglial Dependent Protective Effects of Neuroactive Steroids. Lanussa OH, Ávila-Rodriguez M, García-SeguraL M, González J, Echeverria V, Aliev G and Barreto GE Article CNS Neurol Disord Drug Targets (2016)
Neuroinflammation: a therapeutic target of cotinine for the treatment of psychiatric disorders. Echeverria MV, Grizzell JA, Barreto GE. Article Current Pharmaceutical Design (2016)
Neuroprotective effects of the catalytic subunit of telomerase=> A potential therapeutic target in the central nervous system. González-Giraldo, Yeimy; Forero, Diego A; Echeverria, Valentina; Gonzalez, Janneth; Ávila-Rodriguez, Marco; Garcia-Segura, Luis Miguel; Barreto, George E Article Ageing research reviews (2016)
Novel Approaches in Astrocyte Protection: from Experimental Methods to Computational Approaches Garzón D, Cabezas R, Vega N, Ávila-Rodriguez M, Gonzalez J, Rosa Gómez M, EcheverriaV, Aliev G, Barreto, GE Article J Mol Neurosci (2016)
Positive modulators of the α7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer's disease Echeverria V, Yarkov A Article PROGRESS IN NEUROBIOLOGY (2016)
Positive modulators of the alpha7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer’s disease Echeverria V. Yarkov A, Gjumrakch A Article Positive modulators of the alpha7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer’s disease (2016)
Positive modulators of the Î±7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer's disease. Echeverria, Valentina; Yarkov, Alex; Aliev, Gjumrakch Article Progress in neurobiology (2016)
Post-treatment with cotinine improved memory and decreased depressive-like behavior after chemotherapy in rats Article CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)
Protection by Neuroglobin Expression in Brain Pathologies. Baez, Eliana; Echeverria, Valentina; Cabezas, Ricardo; Ávila-Rodriguez, Marco; Garcia-Segura, Luis Miguel; Barreto, George E Article Frontiers in neurology (2016)
Relationship Between Obesity, Alzheimer's Disease, and Parkinson's Disease=> an Astrocentric View. Martin-Jiménez, Cynthia Alexandra; Gaitán-Vaca, Diana Milena; Echeverria, Valentina; González, Janneth; Barreto, George E Article Molecular neurobiology (2016)
Role of neuroinflammation and sex hormones in war-related PTSD. Mendoza, Cristhian; Barreto, George E; Ávila-Rodriguez, Marco; Echeverria, Valentina Article Molecular and cellular endocrinology (2016)
Role of neuroinflammation and sex hormones in war-related PTSD. Mendoza C, Barreto GE; Ávila-Rodriguez M, Echeverria V Article Molecular Cellular Endocrinology (2016)
Targeting the nicotinic acetylcholine receptors (nAChRs) in astrocytes as a potential therapeutic target in Parkinson’s disease Jurado-Coronel JC, Echeverria MV, Gonzalez J, Barreto GE. Article Targeting the nicotinic acetylcholine receptors (nAChRs) in astrocytes as a potential therapeutic target in Parkinson’s disease (2016)
Testosterone Protects Mitochondrial Function and Regulates Neuroglobin Expression in Astrocytic Cells Exposed to Glucose Deprivation. Toro-Urrego, Nicolas; Garcia-Segura, Luis M; Echeverria, Valentina; Barreto, George E Article Frontiers in aging neuroscience (2016)
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson’s disease. Barreto GE, Yarkov A, and Echeverria V. Article Frontiers in Aging Neurosci. Front. Aging Neurosci. (2015)
Nanoparticles as Alternative Strategies for Drug Delivery to the Alzheimer Brain: Electron Microscopy Ultrastructural Analysis Aliev G.; Daza, J; Herrera, AS; Esparza, MDA; Morales L.; Echeverria V.; Bachurin, SO; Barreto, GE Article CNS and Neurological Disorders - Drug Targets (2015)
Nanoparticles as Alternative Strategies for Drug Delivery to the Alzheimer Brain=> Electron Microscopy Ultrastructural Analysis Aliev G., Daza; J, Herrera; AS, Esparza; MDA, Morales L; Echeverria V., Bachurin; SO, Barreto GE Article CNS and Neurological Disorders - Drug Targets (2015)
New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine. Grizzell, J Alex; Echeverria, Valentina Article Neurochemical research (2015)
Nicotine-derived compounds as therapeutic tools against post-traumatic stress disorder Barreto G.E.; Yarkov A.; Ávila-Rodriguez M.; Aliev G.; Echeverria V. Article Current Pharmaceutical Design (2015)
Nicotine-Derived Compounds as Therapeutic Tools Against Post-Traumatic Stress Disorder Barreto, GE; Yarkov, A; Avila-Rodriguez, M; Aliev, G; Echeverria, V Article ISI CURRENT PHARMACEUTICAL DESIGN (2015)
Cotinine halts the advance of Alzheimer’s disease-like pathology and associated depressive-like behavior in Tg6799 mice Sagar Patel, J Alex Grizzel, Rosalee Holmes, Ross Zeitlin, Rosalynn Solomon, Thomas Lee Sutton, Adeeb Rohani, Laura Charry, Alexandre Iarkov,Takashi Mori, Valentina Echeverria Moran Article Frontiers in Aging Neuroscience (2014)
Cotinine Reduces Depressive-Like Behavior and Hippocampal Vascular Endothelial Growth Factor Downregulation After Forced Swim Stress in Mice Grizzell JA; Mullins M.; Iarkov A.; Rohani, A; Charry, LC; Echeverria, V Article ISI SCOPUS BEHAVIORAL NEUROSCIENCE (2014)
Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice Grizzell, JA; Iarkov, A; Holmes, R; Mori, T.; Echeverria V. Article Behavioural Brain Research (2014)
Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice Grizzell, JA; Iarkov, A; Holmes, R; Mori, T. Article Behavioural Brain Research (2014)
Brain effects of Nicotine and Derived Compounds Moran Echeverria V Article Front. Pharmacol (2013)
Cotinine Enhances the Extinction of Contextual Fear Memory and Reduces Anxiety after fear conditioning. Zeitlin R, Patel S, Solomon R, Tran J, Weeber EJ, and Echeverria V. Article Behavioral Brain Research (2012)
Cotinine: a potential new therapeutic agent against Alzheimer's disease. Echeverria V, Zeitlin R. Article CNS Neuroscience &Therapeutics. (2012)
Cotinine: Beyond that Expected, More than a Biomarker of Tobacco Consumption. Moran Echeverria V. Article Front. Pharmacol. (2012)
Caffeine Induces Beneficial Changes in PKA Signaling and JNK and ERK Activities in the Striatum and Cortex of Alzheimer’s Transgenic Mice Zeitlin R, Patel S, Burgess S, Arendash G W, Echeverria V. Article Brain research (2011)
Raf Inhibitors as Therapeutic Agents against Neurodegenerative Diseases Burgess S and Echeverria V. Article CNS & Neurological Disorders-Drug Targets (2010)
Caffeine reverses cognitive impairment and decreases brain Abeta levels in aged Alzheimer’s mice. Arendash WG, Mori T, Mamcarz M, Dickson A, Runfeldt M, Rezai-Zadeh K, Citron B, Tan J, Lin X, Cao Ch, Echeverria V, and Potter H. Article J. Alzheimer’s Disease (2009)
Sorafenib inhibited cRaf-1/NF-kappaB pathway and restored working memory in aged APPswe mice. Echeverria V, Burgess S, Gamble-George J, Zeitlin RS, Mamcarz M, Cao C, Arendash WG. Article Neuroscience (2009)
Raf inhibition is Neuroprotective against Amyloid beta toxicity. Echeverria V, Burgess S, Dickson A, Arendash WG, Citron AB Article Neuroscience Lett (2008)
Transcription factor Sp1 dysregulation in Alzheimer’s disease. Citron, B A., Dennis, J S., Zeitlin, RS, Echeverria V. Article J Neuroscience Res (2008)
Oligomers of beta-amyloid peptide inhibit BDNF-induced arc expression in cultured cortical Neurons. Echeverria, Valentine; Berman, Diego E; Arancio, Ottavio Article Current Alzheimer research (2007)
1-hydroxyPGE reduces infarction volume in mouse transient cerebral ischemia. Ahmad, Muzamil; Saleem, Sofiyan; Zhuang, Hean; Ahmad, Abdullah Shafique; Echeverria, Valentina; Sapirstein, Adam; Doré, Sylvain Article The European journal of neuroscience (2006)
Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity. Ahmad, Abdullah Shafique; Zhuang, Hean; Echeverria, Valentina; Doré, Sylvain Article Journal of neurotrauma (2006)
Endogenous beta-amyloid peptide synthesis modulates cAMP response element-regulated gene expression in PC12 cells. Echeverria, V; Ducatenzeiler, A; Chen, C H; Cuello, A C Article Neuroscience (2005)
Expression of prostaglandin E2 synthases in mouse postnatal cortical neurons. Echeverria, Valentina; Greenberg, David L; Doré, Sylvain Article Annals of the New York Academy of Sciences (2005)
Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure. Echeverria, Valentina; Clerman, Andrew; Doré, Sylvain Article The European journal of neuroscience (2005)
Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Echeverria, V; Ducatenzeiler, A; Dowd, E; Jänne, J; Grant, S M; Szyf, M; Wandosell, F; Avila, J; Grimm, H; Dunnett, S B; Hartmann, T; Alhonen, L; Cuello, A C Article Neuroscience (2004)
Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex. Echeverria, Valentina; Ducatenzeiler, Adriana; Alhonen, Leena; Janne, Juhani; Grant, Susan M; Wandosell, Francisco; Muro, Andres; Baralle, Francisco; Li, Hongshan; Duff, Karen; Szyf, Moshe; Cuello, A Claudio Article Journal of Alzheimer's disease => JAD (2004)
Intracellular A-beta amyloid, a sign for worse things to come? Echeverria V, Cuello AC. Article MOLECULAR NEUROBIOLOGY (2002)
Mutagenesis in the switch IV of the helical domain of the human Gs alpha reduces its GDP/GTP exchange rate Echeverria, V; Hinrichs, MV; Torrejón M.; Ropero, S; Martinez, J.; Toro, MJ; Olate, J Article ISI JOURNAL OF CELLULAR BIOCHEMISTRY (2000)
Mutagenesis in the switch IV of the helical domain of the human Gs? reduces its GDP/GTP exchange rate Echeverria, V; Hinrichs M.V.; Torrejón M.; Martinez, J.; Olate, J; Ropero, S; Toro M.J. Article SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2000)
The DREAM-DRE interaction: key nucleotides and dominant negative mutants. Ledo, F; Link, W A; Carrión, A M; Echeverria, V; Mellström, B; Naranjo, J R Article Biochimica et biophysica acta (2000)
The C2 cytosolic loop of adenylyl cyclase interacts with the activated form of G alpha s. Torrejón, M; Genevière, A M; Echeverría, V; Guzmán, L; Hinrichs, M V; Olate, J Article FEBS letters (1998)
Molecular cloning and expression of an adenylyl cyclase from Xenopus laevis oocytes. Torrejón, M; Echeverría, V; Retamales, G; Herrera, L; Hinrichs, M V; Olate, J Article FEBS letters (1997)
Partial DNA sequence of a beta-lactamase produced by a Shigella flexneri strain. Echeverría, V; Olate, J; Cid, H Article Microbios (1995)
Characterization of a plasmid codifying the synthesis of a beta-lactamase produced by Shigella flexneri. Echeverría, V; Mondaca, M A; Montoya, R; Bunster, M; Cid, H Article Microbios (1993)


Combination of cotinine plus antioxidant for treatment-resistant depression and correction of astrocytes functional deficit induced by depression and other neuropathological Echeverría Morán, Valentina. Patent (2022)
Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with a-beta peptide aggregation Echeverría Morán, Valentina. Patent (2022)
Use of cotinine in treating or preventing neurogenesis deficits and enhancing neurogenesis Echeverría Morán, Valentina. Patent (2019)
Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation Echeverría Morán, Valentina. Patent (2017)


Role of bone-morphometric proteins in the enhancement of fear extinction and astrocyte protection induced by cotinine in fear-conditioned mice FONDECYT (1190264) Proyecto 2019-2023 Inv. Principal
INVESTIGATING COTININE AS A THERAPY FOR POST-TRAUMATIC STRESS DISORDER FONDECYT (1150194) Proyecto 2015-2019 Inv. Responsable
Memory enhancing effects of high-energy compounds plus cotinine in aged mice Bay Pines Foundation Inc. (BPF #2935) Proyecto 2014-2014 Coinvestigador(a)
Cotinine to reduce Chemotherapy-induced Cognitive Impairment Bay Pines Foundation Inc (BPF # 9293) Proyecto 2013-2014 Inv. Principal
Investigating Cotinine to Improve Memory and Prevent Tobacco Abuse in Subjects with Cognitive Impairment due to Psychiatric Disorders Department of Health of Florida (10KG-03) Proyecto 2010-2013 Inv. Principal
Cotinine as a Therapeutic Tool against Alzheimer’s disease Florida Alzheimer’s Disease Research Center (NIH Subaward No. 6111-1017-93-A) Proyecto 2008-2010 Inv. Principal
Molecular Mechanisms Underlying the Neuroprotective Actions of Cotinine Alzheimer’s Association (NIRG-08-91031) Proyecto 2008-2010 Inv. Principal
Role of cRaf-1/ERK Pathway on Cotinine Neurotoxicity Department of Health of Florida (DOH=> 7KN-04) Proyecto 2007-2010 Inv. Principal
CARACTERIZACION FUNCIONAL DEL DOMINIO HELICOIDAL DE LA SUBUNIDAD GAS DE LA PROTEINA G FONDECYT (2970061) Proyecto 1997-1999 Inv. Responsable


Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds Hidalgo-Lanussa O.; Baez-Jurado E.; Echeverria V.; Ashraf G.M.; Sahebkar A.; Garcia-Segura L.M.; Melcangi R.C.; Barreto G.E. Review ISI SCOPUS JOURNAL OF NEUROENDOCRINOLOGY (2020)
Strategies for the Treatment of Parkinson’s Disease: Beyond Dopamine Iarkov A.; Barreto G.E.; Grizzell J.A.; Echeverria V. Review ISI SCOPUS (2020)
Secretome of Mesenchymal Stem Cells and Its Potential Protective Effects on Brain Pathologies Baez-Jurado E.; Hidalgo-Lanussa O.; Barrera-BailÃ³n B.; Sahebkar A.; Ashraf G.M.; Echeverria V.; Barreto G.E. Review ISI SCOPUS MOLECULAR NEUROBIOLOGY (2019)
RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration Gasiorowski, K; Brokos, B; Echeverria, V; Barreto, GE; Leszek, J Review ISI MOLECULAR NEUROBIOLOGY (2018)
Sex differences in Parkinsons disease: Features on clinical symptoms, treatment outcome, sexual hormones and genetics Jurado-Coronel, JC; Cabezas, R; Rodriguez, MFA; Echeverria, V; Garcia-Segura, LM; Barreto, GE Review ISI SCOPUS FRONTIERS IN NEUROENDOCRINOLOGY (2018)
Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system González-Giraldo Y.; Forero D.A.; Echeverria, V; Gonzalez, J; Ávila-Rodriguez M.; Garcia-Segura, L. M.; Barreto, G. E. Review ISI SCOPUS AGEING RESEARCH REVIEWS (2016)