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Dante Mauricio Miranda Wilson

Director de Extensión

Universidad de Chile, Faculatd de Ciencias Químicas y Farmacéuticas

Santiago, Chile

Regulación de la función de las células NK, Inmunidad y envejecimiento, Inhibición de la proliferación de células tumorales por compuestos químicos de interés biológico.

Bioquímica, UNIVERSIDAD DE CHILE. Chile, 1998
Bioquimica, UNIVERSIDAD DE CHILE. Chile, 1984

Profesor Adjunto Full Time

UNIVERSIDAD DE CHILE

Ciencias Químicas y Farmacéuticas

SANTIAGO, Chile

1988 - At present

Postdoctoral fellow Full Time

West Virginia University

Morgantown, Estados Unidos

1984 - 1987

Undergraduate supervisor

2019

Barbara Plaza Riquelme. (Co.director). Study of the role of P2X7R in the increase in cell proliferation and mitochondrial mass induced by IL-2 in CD4 + lymphocytes during Treg lymphocyte cell differentiation.
Bioquímica. Universidad de Santiago de Chile.

2018

Marta Cortez Cortez. (Co.director). Study of the role of P2X7 receptor in the IL-2 signaling pathway in murine NK cells.
Bioquímica. Universidad de Santiago de Chile.

2015

Karla Alfaro Elizalde. (co-director). Study of the induction of migration and invasion in tumor cells mediated by reactive oxygen species generated by lactate
Bioquímica. Universidad de Santiago de Chile.

2014

Benita Godoi Bravo.(Co-director). Study of the participation of the transcriptional factor CREB in signal transduction mediated by IL-2 in human NK cells and its relation with immunosenescence.
Biotecnólogo. Universidad Mayor.

Alonso Ureta Dumond. (Co-director) Study of the role of PGC1? in the invasion and secretion of RANTES in human IL-2 activated NK cells.
Bioquímico. Universidad de Santiago de Chile

2013

Jorge Ibañez Vega. (Co-director) Study of the immunosuppressive activity of Treg cells on the function of NK cells during aging in a murine model.
Bioquímico. Universidad de Santiago de Chile.

Sophía Mejías Medina. Study of mitochondrial dynamics in the IL-2 mediated activation of elder human NK.
Bioquímica. Universidad de Santiago de Chile.


An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells Donoso-Bustamante, V., Borrego, E. A., Schiaffino-Bustamante, Y., Gutiérrez, D. A., PabloMillas-Vargas, J., Fuentes-Retamal, S., Correa, P., Carrillo, I., Aguilera, R. J., Miranda, D., Chávez-Báez, I., Pulgar, R., Urra, F. A., Varela-Ramírez, A., Araya-Ma Article WOS Core collection ISI BIOORGANIC CHEMISTRY (2020)
Deficient mitochondrial biogenesis in IL-2 activated NK cells correlates with impaired PGC1-alpha upregulation in elderly humans Miranda, Dante; Jara, Claudia; Mejias, Sophia; Ahumada, Viviana; Cortez-San Martin, Marcelo; Ibanez, Jorge; Hirsch, Sandra; Montoya, Margarita Article ISI SCOPUS EXPERIMENTAL GERONTOLOGY (2018)
PGC-1Î±-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells. Miranda, Dante; Jara, Claudia; Ibañez, Jorge; Ahumada, Viviana; Acuña-Castillo, Claudio; Martin, Adrian; Córdova, Alexandra; Montoya, Margarita Article Mediators of inflammation (2016)
Folates Induce Colorectal Carcinoma HT29 Cell Line Proliferation Through Notch1 Signaling Rodriguez, JM; Miranda D.; Bunout, D; Ronco, AM; de la Maza, MP; Hirsch, S Article ISI SCOPUS Nutrition and Cancer (2015)
Natural killer cell cytotoxicity is not regulated by folic acid in vitro Hirsch, S; Miranda D.; Muñoz E; Montoya, M; Ronco, AM; de la Maza, MP; Bunout, D Article ISI SCOPUS Nutrition (2013)
Effect of supraphysiological concentration of serum folate on natural killer cell activity in healthy subjects Hirsch, S; Miranda D.; Fuentes C.; Leiva, L; Barrera, G; Montoya, M; Ronco A.M.; De La Maza M.P.; Bunout, D Article SCOPUS e-SPEN Journal (2012)
Evaluation of the immune response against immature viral particles of infectious pancreatic necrosis virus (IPNV): A new model to develop an attenuated vaccine Rivas-Aravena, A; Martin M.C.S.; Galaz J.; Imarai M.; Miranda D.; Spencer E.; Sandino, A.M. Article ISI SCOPUS Vaccine (2012)
Polymyxin B increases the depletion of T regulatory cell induced by purinergic agonist Cappelli C.; López, X; Labra, Y; Montoya, M; Fernandez, R.; Imarai M.; Rojas, J.L.; Miranda D.; Escobar A.; Acuna-Castillo, C Article ISI SCOPUS Immunobiology (2012)
DPPH and oxygen free radicals as pro-oxidant of biomolecules Letelier, ME; Molina-Berrios, A; Cortes-Troncoso, J; Jara-Sandoval, J; Holst, M; Palma K.; Montoya, M; Miranda D.; Gorizalez-Lira, V Article ISI SCOPUS Toxicology in vitro : an international journal published in association with BIBRA. (2008)
Copper modifies liver microsomal UDP-glucuronyltransferase activity through different and opposite mechanisms Letelier, ME; Lagos F.; Faundez, M; Miranda D.; Montoya, M; Aracena-Parks, P; Gonzalez-Lira, V Article ISI SCOPUS CHEMICO-BIOLOGICAL INTERACTIONS (2007)
Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)-anthracenone derivatives on tumor cell respiration Araya-Maturana, R; Cardona W.; CASSELS, BK; Delgado-Castro, T; Ferreira J.; Miranda D.; Pavani, M.; Pessoa-Mahana H.; Soto-Delgado, J; Weiss-Lopez, B Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Innate immunity restoration in patients with HIV/AIDS infection associated with antiretroviral therapy Afani, A; Jiusan, L; Raby, P; Sitia, G; Puente J.; Sepulveda, C; Miranda D.; Cabrera, R; Guidotti, L; Lanza, P Article ISI REVISTA MEDICA DE CHILE (2006)
Spectroelectrochemical study on the electrooxidation in aqueous médium of some 1,4-dihydropyridines: Effects of substitution in 1-position and 4-position Lopez-Alarcon, C; Squella, JA; Miranda-Wilson, D; Nunez-Vergara, LJ Article ISI, SCOPUS ELECTROANALYSIS (2004)
Human natural killer cell lysis of Salmonella typhi intracellularly-infected U937 cells Miranda D.; Puente J.; Blanco, L; Jara P.; Wolf M.E.; Mosnaim A.D. Article SCOPUS Research Communications in Molecular Pathology and Pharmacology (2002)
Effect of salmonella-infected human monocytes on natural killer cell cytotoxicity. In vitro studies Blanco, L; Puente J.; Carrasco C.; Miranda D.; Wolf, ME; Mosnaim, AD Article ISI INTERNATIONAL IMMUNOPHARMACOLOGY (2001)
Effect of Salmonella typhi wild type and O-antigen mutants on human natural killer cell activity Puente J.; Blanco, L; Montoya, M; Miranda D.; Contreras, I; Vines E.; Wolf, ME; Mosnaim, AD Article ISI SCOPUS INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY (2000)


REGIO- AND STEREO-SELECTIVE DIELS-ALDER REACTIONS IN THE SYNTHESIS OF CDC25B FOSFATASE INHIBITORS FONDECYT (1110176) Proyecto 2011-2014 Coinvestigador(a)
EFECTO DE NIVELES SUPRAFISIOLOGICOS DE FOLATO SOBRE LA ACCION DE CELULAS NATURAL KILLER. POSIBLES IMPLICANCIAS PATOLOGICAS FONDECYT (1090166) Proyecto 2009-2012 Coinvestigador(a)
ESTUDIO BIOELECTROQUIMICO DE COMPUESTOS DE INTERES BIOLOGICO FONDECYT (8000016) Proyecto 2000-2005 Investigador(a)
INMUNORREGULACION DE LAS CELULAS NK MEDIADA POR BACTERIAS FONDECYT (1970226) Proyecto 1997-2000 Coinvestigador(a)
ESTUDIO DE LA CITOLISIS MEDIADA POR LAS CELULAS NK Y SU REGULACION POR FOSFORILACION DE PROTEINAS => PROYECCIONES A LA PATOLOGIA INFECCIOSA FONDECYT (1930991) Proyecto 1993-1996 Coinvestigador(a)
ESTUDIO DE LA REGULACION DE LA ACTIVIDAD NATURAL KILLER (NK) => FONDECYT (2920050) Proyecto 1992-1994 Inv. Responsable
ACCIONES AUTOCRINAS Y PARACRINAS DEL FACTOR DE CRECIMIENTO FIBROBLASTICO BASICO (bFGF) EN LAS DISTINTAS ETAPAS DEL DESARROLLO MAMARIO Y EN LA LACTOGENESIS FONDECYT (1910879) Proyecto 1991-1993 Coinvestigador(a)
REGULACION DE LA CITOLISIS NATURAL (NK) E INDUCIDA POR INTERLEUKOINA-2. FONDECYT (1901115) Proyecto 1990-1993 Investigador(a)
ESTUDIOS SOBRE LA EXPRESION DE GENES DE RNA RIBOSOMAL DE THIOBACILLUS FERROOXIDANS. FONDECYT (1880450) Proyecto 1988-1991 Coinvestigador(a)
INMUNOMODULACION DE LA CITOTOXICIDAD NK (NATURAL KILLER) POR NEUROPEPTIDOS. FONDECYT (1880874) Proyecto 1988-1990 Coinvestigador(a)