Man

Jose Carlo Galaz Alarcon

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Educación

  •  Maternal-Fetal Immunology, WAYNE STATE UNIVERSITY. Estados Unidos, 2021
  •  Medical Doctor, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2015
  •  Obstetrics and Gynecology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2019

Experiencia Académica

  •   Assistant Professor Full Time

    WAYNE STATE UNIVERSITY

    Medicine

    Detroit, Estados Unidos

    2021 - 2023

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2024 - At present

Experiencia Profesional

  •   Obstetrician Full Time

    Red Salud UC-Christus

    Chile

    2023 - At present


 

Article (55)

Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing
Dissociation of Placental Tissues for Single-Cell Techniques
Immunophenotyping of Leukocytes in Amniotic Fluid
The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B
A single-cell atlas of murine reproductive tissues during preterm labor
Blockade of IL-6R prevents preterm birth and adverse neonatal outcomes
Differential immunophenotype of circulating monocytes from pregnant women in response to viral ligands
Further evidence that an episode of premature labor is a pathologic state: involvement of the insulin-like growth factor system
Host-microbiome interactions in distinct subsets of preterm labor and birth
Immunosequencing and Profiling of T Cells at the Maternal-Fetal Interface of Women with Preterm Labor and Chronic Chorioamnionitis
Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma
The amniotic fluid proteome changes with term labor and informs biomarker discovery in maternal plasma
The effects of progesterone on immune cellular function at the maternal-fetal interface and in maternal circulation
The MNRR1 activator nitazoxanide abrogates lipopolysaccharide-induced preterm birth in mice
The Vaginal Microbiota of Pregnant Women Varies with Gestational Age, Maternal Age, and Parity
Thymic stromal lymphopoietin participates in the host response to intra-amniotic inflammation leading to preterm labor and birth
A single-cell atlas of the myometrium in human parturition
Cellular immune responses in the pathophysiology of preeclampsia
Clarithromycin prevents preterm birth and neonatal mortality by dampening alarmin-induced maternal-fetal inflammation in mice
Defining a role for Interferon Epsilon in normal and complicated pregnancies
Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women
Does the Amniotic Fluid of Mice Contain a Viable Microbiota?
Fetal and maternal NLRP3 signaling is required for preterm labor and birth
IL-22 Plays a Dual Role in the Amniotic Cavity: Tissue Injury and Host Defense against Microbes in Preterm Labor
Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2
Microbiota of the Pregnant Mouse: Characterization of the Bacterial Communities in the Oral Cavity, Lung, Intestine, and Vagina through Culture and DNA Sequencing
Pregnancy imparts distinct systemic adaptive immune function
Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation
Single-Cell Immunobiology of the Maternal-Fetal Interface
Specific innate immune cells uptake fetal antigen and display homeostatic phenotypes in the maternal circulation
The amniotic fluid proteome predicts imminent preterm delivery in asymptomatic women with a short cervix
Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth
Betamethasone as a potential treatment for preterm birth associated with sterile intra-amniotic inflammation: a murine study
Human Chorionic Gonadotropin Modulates the Transcriptome of the Myometrium and Cervix in Late Gestation
RNA Sequencing Reveals Distinct Immune Responses in the Chorioamniotic Membranes of Women with Preterm Labor and Microbial or Sterile Intra-amniotic Inflammation
The alarmin S100A12 causes sterile inflammation of the human chorioamniotic membranes as well as preterm birth and neonatal mortality in mice
Vaginal host immune-microbiome interactions in a cohort of primarily African-American women who ultimately underwent spontaneous preterm birth or delivered at term
A Protocol for Evaluating Vital Signs and Maternal-Fetal Parameters Using High-Resolution Ultrasound in Pregnant Mice
Cellular immune responses in amniotic fluid of women with a sonographic short cervix
Cellular immune responses in amniotic fluid of women with preterm clinical chorioamnionitis
Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes
Intra-Amniotic Infection with <i>Ureaplasma parvum</i> Causes Preterm Birth and Neonatal Mortality That Are Prevented by Treatment with Clarithromycin
Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes
No Consistent Evidence for Microbiota in Murine Placental and Fetal Tissues
Pregnancy-specific transcriptional changes upon endotoxin exposure in mice
Prenatal Maternal Stress Causes Preterm Birth and Affects Neonatal Adaptive Immunity in Mice
Regulatory T Cells Play a Role in a Subset of Idiopathic Preterm Labor/Birth and Adverse Neonatal Outcomes
The alarmin interleukin-1α causes preterm birth throught the NLRP3 inflammasome
Are B cells altered in the decidua of women with preterm or term labor?
Cellular immune responses in amniotic fluid of women with preterm labor and intra-amniotic infection or intra-amniotic inflammation
Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor
Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth
Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia
Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia

Review (4)

Is there a placental microbiota? A critical review and re-analysis of published placental microbiota datasets
The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal-fetal homeostasis
<i>Sneathia</i>: an emerging pathogen in female reproductive disease and adverse perinatal outcomes
Inflammasomes: Their Role in Normal and Complicated Pregnancies
59
Jose Galaz

Assistant Professor

Obstetrics

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

2
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Stephanie Acuña

Asistente de Investigación

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Francisco Valenzuela

Academico

Ciencias Básicas

UNIVERSIDAD DEL BÍO BÍO

Chillan, Chile