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Francisco Javier Valenzuela Melgarejo

Academico

UNIVERSIDAD DEL BÍO BÍO

Chillan, Chile

Fisiologia; Endocrinología; Sistema Circadiano; Biología Celular y Molecular

Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2012
Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2005

Academico Full Time

UNIVERSIDAD DEL BIO-BIO

Ciencias

Chillán, Chile

2012 - At present

Asistente Investigación Fondecyt (1110883) Full Time

Universidad de los Andes

Santiago, Chile

2011 - 2012
Director Alterno Proyecto CORFO (11IDL2-10487) Other

Universidad de los Andes

Santiago, Chile

2011 - 2012

He dirigido 3 tesis de Pregrado: “MELATONINA Y SU ROL SOBRE EL SISTEMA CIRCADIANO DE LA PLACENTA HUMANA”, Ped. Ciencias, 2014, Marcela Pradenas ; “HIGH LEVEL OF CLOCK GENE PER1 IS DETECTED IN PLACENTAS FROM PREECLAMPSIA”. Ped. Ciencias, 2014, Karen Muñoz, Sara Muñoz, Solange Oyarce; “PAPEL DEL SISTEMA CIRCADIANO Y DE MELATONINA EN LAS PATOLOGÍAS DEL EMBARAZO” Bachillerato, 2013. Fabiola Pino.

He dirigido 1 tesis de Postgrado: “EL SISTEMA CIRCADIANO MODULA EL CICLO CELULAR DE LA PLACENTA: MECANISMO MOLECULAR DEL CONTROL CELULAR”, Magister en Cs. Biológicas, 2015. Carlos Venegas.


Effect of metal in Schiff bases of chitosan adsorbed on glassy carbon electrode in the inhibition of sphingomyelinase C toxin Caro-Diaz, Claudia A.; Lillo-Arroyo, Luis; Valenzuela-Melgarejo, Francisco J.; Roudergue-Zuniga, Victor; Cabello-Guzman, Gerardo Article ISI SCOPUS FOOD AND CHEMICAL TOXICOLOGY (2018)
Preliminary evaluation of the up-conversion emission of Y2O3=>Er-Yb thin films prepared by a solid state photochemical deposition method Cabello-Guzmán, G.; González, Diego; Caro-Díaz, C.; Lillo-Arroyo, L.; Valenzuela-Melgarejo, F.; Cárdenas Triviño, G.; Buono-Core, G.E.; Chornik, B.; Huentupil, Yosselin Article JOURNAL OF LUMINESCENCE (2018)
Study on the photochemical preparation of nickel gallium oxide spinel doped with Eu(III) ions from carboxylate and beta-diketonate complexes and the evaluation of its optical properties Cabello-Guzman, G.; Lillo-Arroyo, L.; Caro-Díaz, C.; Valenzuela-Melgarejo, F.; Fernandez-Perez, A.; Buono-Core, G.E.; Chornik, B. Article THIN SOLID FILMS (2018)
"Deciphering the function of the blunt circadian rhythm of melatonin in the newborn lamb=> Impact on adrenal and heart.", # en.2017-00254R2 Seron-Ferre M., Torres-Farfan C.; Valenzuela F.J., Castillo-Galan S.; Rojas A., Reynolds H.; Valenzuela G.J., Llanos A.J. Article Endocrinology (2017)
Carriage of Staphylococcus aureus among food service workers Alarcon-Lavin, MP; Oyarzo, C; Escudero, C; Cerda-Leal, F; Valenzuela, FJ Article ISI REVISTA MEDICA DE CHILE (2017)
Mechanistic characterization and inhibition of sphingomyelinase C over substituted Iron Schiff bases of chitosan adsorbed on glassy carbon electrode Caro, Claudia A.; Lillo, Luis; Valenzuela, Francisco J.; Cabello, Gerardo Article ISI SCOPUS CHEMICO-BIOLOGICAL INTERACTIONS (2017)
PORTACIÒN DE STAPHYLOCOCCUS AUREUS ENTEROTOXIGÈNICO TIPO A, EN FROTIS NASOFARINGEOS EN MANIPULADORAS DE ALIMENTOS Alarcón-Lavin María Paula, Oyarzo Carolina; Escudero Carlos, Cerda-Leal Fabiola Article Revista Medica de Chile (2017)
Oxidation of melatonin on a glassy carbon electrode modified with metallic glucosamines. Caro CA,; Valenzuela FJ.; Cabello C; Lang E; Vallejos D; Castillo C Article J Solid State Electrochem (2016)
Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature Valenzuela, F. J.; Vera, J.; Venegas, C.; Muñoz, S.; Oyarce, S.; Muñoz, K.; Lagunas, C. Article ISI SCOPUS INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2016)
Oxidation of melatonin on a glassy carbon electrode modified with metallic glucosamines. Synthesis and characterization Caro C.A.; Lillo L.; Valenzuela F. J.; Cabello, G; Lang, E.; Vallejos, D.; Castillo C. Article ISI SCOPUS JOURNAL OF SOLID STATE ELECTROCHEMISTRY (2016)
Circadian System and Melatonin Hormone: Risk Factors for Complications during Pregnancy Valenzuela, F. J.; Vera, J.; Venegas, C.; Pino, F.; Lagunas, C. Article Obstetrics and Gynecology International (2015)
Impact of maternal melatonin suppression on amount and functionality of brown adipose tissue (BAT) in the newborn sheep Seron-Ferre, M.; Reynolds H.; Mendez, N.; Mondaca, M.; Valenzuela F. J.; R E.; Valenzuela G.J.; Herrera, E. A.; Llanos, A. J.; Torres-Farfan, C. Article SCOPUS FRONTIERS IN ENDOCRINOLOGY (2014)
Increased placental angiogenesis in late and early onset pre-eclampsia is associated with differential activation of vascular endothelial growth factor receptor 2 Escudero C, Celis C, Saez T, San Martin S, Valenzuela FJ, Aguayo C, Bertoglia P, Roberts JM, Acurio J Article ISI PLACENTA (2014)
Impact of Chronodisruption during Primate Pregnancy on the Maternal and Newborn Temperature Rhythms Seron-Ferre, M; Forcelledo, ML; Torres-Farfan, C; Valenzuela, FJ; Rojas A.; Vergara M.; Rojas-Garcia, PP; Recabarren, MP; Valenzuela GJ Article ISI SCOPUS PLOS ONE (2013)
Circadian rhythms in the fetus. Serón-Ferré, María; Mendez, Natalia; Abarzua-Catalan, Lorena; Vilches, Nelson; Valenzuela, Francisco J; Reynolds, Henry E; Llanos, Aníbal J; Rojas, Auristela; Valenzuela, Guillermo J; Torres-Farfan, Claudia Article Molecular and cellular endocrinology (2012)
Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia Perez-Sepulveda, A; Torres, M. J.; Valenzuela F. J.; Larrain, R; Figueroa-Diesel, H; Galaz J.; Nien, J. K.; Serra R.; Michea, L.; Illanes, S. E. Article ISI SCOPUS Prenatal Diagnosis (2012)
Pathogenesis of preeclampsia: The genetic component Valenzuela F. J.; Perez-Sepulveda, A; Torres, M. J.; Correa P.; Repetto G.M.; Illanes, S. E. Article SCOPUS Journal of Pregnancy (2012)
Melatonin Exerts Direct Inhibitory Actions on ACTH Responses in the Human Adrenal Gland Campino C.; Valenzuela, FJ; Torres-Farfan, C; Reynolds, HE; Abarzua-Catalan, L; Arteaga, E; Trucco, C; Guzman, S; Valenzuela GJ; Seron-Ferre, M Article ISI SCOPUS Hormone and Metabolic Research (2011)
Cryptochrome 2 Expression Level Is Critical for Adrenocorticotropin Stimulation of Cortisol Production in the Capuchin Monkey Adrenal Torres-Farfan, C; Abarzua-Catalan, L; Valenzuela, FJ; Mendez, N.; Richter, HG; Valenzuela GJ; Seron-Ferre, M Article ISI SCOPUS ENDOCRINOLOGY (2009)
Circadian cortisol secretion and circadian adrenal responses to ACTH are maintained in dexamethasone suppressed capuchin monkeys (Cebus apella) Torres-Farfan, C; Valenzuela, FJ; Ebensperger, R; Mendez, N.; Campino C.; Richter, HG; Valenzuela GJ; Seron-Ferre, M Article ISI SCOPUS AMERICAN JOURNAL OF PRIMATOLOGY (2008)
Clock gene expression in adult primate suprachiasmatic nuclei and adrenal: Is the adrenal a peripheral clock responsive to melatonin? Valenzuela, FJ; Torres-Farfan, C; Richter, HG; Mendez, N.; Campino C.; Torrealba, F.; Valenzuela GJ; Seron-Ferre, M Article ISI SCOPUS ENDOCRINOLOGY (2008)
Evidence of a role for melatonin in fetal sheep physiology: direct actions of melatonin on fetal cerebral artery, brown adipose tissue and adrenal gland Torres-Farfan, C; Valenzuela, FJ; Mondaca, M.; Valenzuela GJ; Krause, B; Herrera EA; Riquelme R.; Llanos, AJ; Seron-Ferre, M Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2008)
La melatonina reduce la respuesta de cortisol al ACTH en humanos Campino, Carmen; Valenzuela, Francisco; Arteaga, Eugenio; Torres-Farfán, Claudia; Trucco, Cristian; Velasco, Alfredo; Guzmán, Sergio; Serón-Ferré, María Article SCIELO REVISTA MEDICA DE CHILE (2008)
Melatonin reduces cortisol response to ACTH in humans Campino C.; Valenzuela F.; Arteaga, E; Torres-Farfan, C; Trucco, C; Velasco, A; Guzman, S; Seron-Ferre, M Article ISI REVISTA MEDICA DE CHILE (2008)
Melatonin reduces cortisol response to ACTH in humans La melatonina reduce la respuesta de cortisol al ACTH en humanos Campino C.; Arteaga, E; Valenzuela F.; Torres-Farfan, C; Seron-Ferre, M; Trucco, C; Velasco, A; Guzman, S Article SCOPUS REVISTA MEDICA DE CHILE (2008)
Maternal melatonin effects on clock gene expression in a nonhuman primate fetus Torres-Farfan, C; Rocco V.; Monso, C; Valenzuela, FJ; Campino C.; Germain A.; Torrealba, F.; Valenzuela GJ; Seron-Ferre, M Article ISI SCOPUS ENDOCRINOLOGY (2006)
Maternal melatonin stimulates growth and prevents maturation of the capuchin monkey fetal adrenal gland Torres-Farfan, C; Valenzuela, FJ; Germain, AM; Viale, ML; Campino C.; Torrealba, F.; Valenzuela GJ; Richter, HG; Seron-Ferre, M Article ISI SCOPUS JOURNAL OF PINEAL RESEARCH (2006)
La melatonina reduce la respuesta de cortisol al ACTH en humanos (2009) Campino Carmen , Valenzuela Francisco , Arteaga Eugenio , Torres-Farfán Claudia , Trucco Cristián , Velasco Alfredo, Guzmán Sergio, Serón-Ferré María Article Revista chilena de Endocrinología y Diabetes (0)
Melatonin reduces cortisol response to ACTH in humans. Campino C, Valenzuela F, Arteaga E, Torres-Farfán C, Trucco C, Velasco A, Guzmán S, Serón-Ferré M. Article Rev Med Chile (0)


The RNA Levels of Keys Enzimes for the Methionine-Homocysteine Metabolism Are Elevated in Placenta of Preeclamptic (PE) Patients Valenzuela, FJ; Perez-Sepulveda, A; Torres, MJ; Galaz J.; Guzman, A.; Mena, F.; Figueroa-Diesel, H; Illanes, S Abstract ISI REPRODUCTIVE SCIENCES (2012)
A Different Temporal Order between Fetal Atrium and Ventricle? Identification of Adrenergic Receptor Beta 1 (ADRB1), Atrial Natriuretic Peptide (ANP), Clock Genes and Melatonin Receptor 1 (MT1) in Fetal Capuchin Monkey Heart. Preliminary Results Rocco V.; Valenzuela, FJ; Torres-Farfan, C; Reynolds H.; Mendez, N.; Abarzua-Catalan, L; Rojas A.; Valenzuela GJ; Seron-Ferre, M Abstract ISI REPRODUCTIVE SCIENCES (2010)
Interactions between Melatonin and ACTH in the Human Adrenal Gland: Adrenal Clockwork Inhibition?. Campino C.; Valenzuela, FJ; Torres-Farfan, C; Abarzua-Catalan, L; Reynolds, HE; Arteaga, E; Trucco, C; Guzman, S; Valenzuela GJ; Seron-Ferre, M Abstract ISI ENDOCRINE REVIEWS (2010)
Different effects of melatonin on PER2 expression in the adrenal gland of fetal and adult Capuchin monkey Valenzuela F.; Monso, C; Torres-Farfan, C; Campino C.; Torrealba, F.; Germain A.; Seron-Ferre, M Abstract ISI PLACENTA (2006)
Differential expression of the clock gene Cry2 in capuchin monkey fetal tissues Rocco V.; Torres-Farfan, C; Valenzuela F.; Torrealba, F.; Germain A.; Campino, B; Seron-Ferre, M Abstract ISI PLACENTA (2006)
Maternal melatonin inhibits 30-hydroxysteroid-dehydrogenase expression in the primate fetal adrenal gland. Torres-Farfan, C; Valenzuela, FJ; Viale, ML; Germain A.; Valenzuela GJ; Campino C.; Torrealba, F.; Richter, HG; Seron-Ferre, M Abstract ISI JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION (2004)
Regulation of 3b-hydroxysteroid dehydrogenase (3b-HSD) expression in the capuchin monkey fetal adrenal gland by maternal melatonin. Torres-Farfan, C; Valenzuela, FJ; Germain, AM; Campino C.; Valenzuela GJ; Richter, HG; Torrealba, F.; Seron-Ferre, M Abstract ISI PEDIATRIC RESEARCH (2004)


The role of placenta in the fetal programming associated to gestational diabetes Carlos Escudero, Francisco Valenzuela, Jesenia Acurio, Luis Sobrevia, Marcelo González; Luis Sobrevia BookSection (2013)


ESTUDIO DE FLUJO DE SANGRE, LA INHIBICIÓN Y LA CINÉTICA DE LA ESFINGOMIELINASA C CON COMPLEJO DE QUITOSÁN Y GLUCOSAMINAS DE HIERRO Y DE COBALTO SOBRE EL ELECTRODO DE CARBONO VÍTREO. EFECTO DE TAMAÑOS COMPLEJOS FONDECYT (1171393) Proyecto 2017-2019 Coinvestigador(a)
PROYECTO SUIZAGUA ANDINA CHILE AGENCIA SUIZA PARA EL DESARROLLO Y LA COOPERACION (COSUDE) Y FUNDACION CHILE (FCH) (Decreto Universitario en proceso) Proyecto 2014-2029 Investigador(a)
ROLE OF ANGIOGENESIS MEDIATED BY THE A2AAR/VEGF SIGNALING PATHWAY IN THE GENERATION OF HYPERTENSION IN OFFSPRING BORN FROM PRE-ECLAMPTIC PREGNANCIES FONDECYT (1140586) Proyecto 2014-2018 Coinvestigador(a)
“Prevalencia de Staphylococcus aureus enterotoxigénicos en frotis nasofaríngeo de manipuladores en servicios de alimentación de escuelas municipalizadas de la comuna de Chillán”. Universidad del Bío Bío (pend) Proyecto 2014-2015 Coinvestigador(a)
“FORTALECIMIENTO DE LA INVESTIGACION EN BIOMEDICINA EN LA UNIVERSIDAD DEL BIO BIO” PAI (79112027) Proyecto 2012-2014 Inv. Principal
"Desarrollo de un test de diagnóstico molecular predictivo de parto prematuro en mujeres embarazadas" (Director Alterno) CORFO (11IDL2-10487) Proyecto 2011-2014 Director(a)
THE METHIONINE-HOMOCYSTEINE CYCLE AND ITS EFFECTS ON THE METABOLISM OF 2-METHOXYOESTRADIOL. THE ROLE OF CATECHOL-O-METHYLTRANSFERASE IN THE ETIOPATHOGENESIS OF PREECLAMPSIA FONDECYT (1110883) Proyecto 2011-2013 Personal técnico y/o de apoyo
"Mecanismo Molecular de la inhibición por melatonina sobre la producción de cortisol estimulada por ACTH" Sociedad Chilena de Endocrinología y Diabetes (2009-07) Proyecto 2009-2009 Inv. Principal
EL SISTEMA CIRCADIANO FETAL=>¿UNA JERARQUIA DE RELOJES PERIFERICOS CIRCADIANOS COORDINADOS POR LA MELATONINA MATERNA? FONDECYT (1080649) Proyecto 2008-2012 Tesista
LA MELATONINA MATERNA COMO SENAL CIRCADIANA EN EL FETO DE PRIMATES-ACCION SOBRE EL OSCILADOR FETAL CENTRAL(NUCLEO SUPRAQUIASMATICO) Y POSIBLES OSCILADORES PERIFERICOS FETALES (HIPOFISIS Y GLANDULA SUPRARRENAL) FONDECYT (1030425) Proyecto 2003-2006 Tesista


Potential Crosstalk between Fructose and Melatonin: A New Role of Melatonin-Inhibiting the Metabolic Effects of Fructose Valenzuela-Melgarejo, FJ; Caro-Diaz, C; Cabello-Guzman, G Review ISI SCOPUS INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2018)
Circadian rhythms in the fetus Seron-Ferre, M; Mendez, N.; Abarzua-Catalan, L; Vilches, N; Valenzuela F. J.; Reynolds H.E.; Llanos, A. J.; Rojas A.; Valenzuela G.J.; Torres-Farfan, C Review ISI SCOPUS Molecular and Cellular Endocrinology (2012)