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Jorge Alejandro Gonzalez Cortes

Profesor Titular

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Invasión celular en Trypanosoma cruzi; Transducción de señales en protozoos parásitos; Bioquímica celular de protozoos parásitos; Búsqueda y evaluación de compuestos con actividad tripanocida; Proteómica de Trypanosoma cruzi

Tecnologo Médico, UNIVERSIDAD DE CHILE. Chile, 1980
Ciencias, Universidad Federal Paulista. Brasil, 1991

Profesor Titular Full Time

UNIVERSIDAD DE ANTOFAGASTA

Ciencias de la Salud

Antofagasta, Chile

1980 - At present


Trypanosoma cruzi pathogenicity involves virulence factor expression and upregulation of bioenergetic and biosynthetic pathways San Francisco J, Astudillo C, Vega JL, Catalán A, Gutiérrez B, Araya JE, Zailberger A, Marina A, García C, Sanchez N, Osuna A, Vilchez S, Ramírez MI, Macedo J, Feijoli VS, Palmisano G, González J Article VIRULENCE (2022)
Observational cross-sectional study of Trichomonas tenax in patients with periodontal disease attending a Chilean university dental clinic Bracamonte-Wolf, Casandra; Orrego, Patricio R.; Munoz, Christian; Herrera, Daniel; Bravo, Joel; Gonzalez, Jorge; Varela, Hector; Catalan, Alejandro; Araya, Jorge E. Article ISI SCOPUS BMC ORAL HEALTH (2019)
Heterophilic antibodies in sera from individuals without loxoscelism cross-react with phospholipase D from the venom of and spiders. Arán-Sekul, Tomás; Rojas, José M; Subiabre, Mario; Cruz, Victoria; Cortés, William; Osorio, Luis; González, Jorge; Araya, Jorge E; Catalán, Alejandro Article The journal of venomous animals and toxins including tropical diseases (2018)
Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. Barría I, Güiza J, Cifuentes F, Zamorano P, Sáez JC, González J, Vega JL Article AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2018)
Decreased cruzipain and gp85/trans-sialidase family protein expression contributes to loss of Trypanosoma cruzi trypomastigote virulence San Francisco, J., Barría, I., Gutiérrez, B., Neira, I., Muñoz, C., Sagua, H., Araya, J., Andrade, J.C., Zailberger, A., Remonsellez, F., Vega, J.L., González, J. Article MICROBES AND INFECTION (2017)
Phospholipase D from Loxosceles laeta Spider Venom Induces IL-6, IL-8, CXCL1/GRO-α, and CCL2/MCP-1 Production in Human Skin Fibroblasts and Stimulates Monocytes Migration. Rojas JM, Arán-Sekul T, Cortés E, Jaldín R, Ordenes K, Orrego PR, González J, Araya JE, Catalán A. Article Toxins (2017)
Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites Muñoz C, San Francisco J, Gutiérrez B, González J. Article Biomed Research International (2015)
A cytoplasmic new catalytic subunit of calcineurin in Trypanosoma cruzi and its molecular and functional characterization. Orrego, Patricio R; Olivares, Héctor; Cordero, Esteban M; Bressan, Albert; Cortez, Mauro; Sagua, Hernán; Neira, Ivan; González, Jorge; da Silveira, José Franco; Yoshida, Nobuko; Araya, Jorge E Article PLoS neglected tropical diseases (2014)
Aromatic glycosyl disulfide derivatives: Evaluation of their inhibitory activities against Trypanosoma cruzi.. Gutiérrez B, Muñoz C, Osorio L, Fehér K, Illyés TZ, Papp Z, Kumar AA, Kövér KE, Sagua H, Araya JE, Morales P, Szilágyi L, González J. Article Bioorg Med Chem Lett (2013)
Role of gap junctions and hemichannels in parasitic infections. Vega JL, Subiabre M, Figueroa F, Schalper KA, Osorio L, González J, Sáez JC Article Biomed Res Int (2013)
In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula. Polanco-Hernández G, Escalante-Erosa F, García-Sosa K, Acosta-Viana K, Chan-Bacab MJ, Sagua- Franco H, González J, Osorio-Rodríguez L, Moo-Puc RE, Peña-Rodríguez LM. Article Parasitol Res (2012)
A protein phosphatase 1 gamma (PP1γ) of the human protozoan parasite Trichomonas vaginalis is involved in proliferation and cell attachment to the host cell. Muñoz C, Pérez M, Orrego PR, Osorio L, Gutiérrez B, Sagua H, Castillo JL, Martínez-Oyanedel J, Arroyo R, Meza-Cervantez P, da Silveira JF, Midlej V, Benchimol M, Cordero E, Morales P, Araya JE, González J. Article Int J Parasitol. (2012)
Extensive Genetic Diversity, Unique Population Structure and Evidence of Genetic Exchange in the Sexually Transmitted Parasite Trichomonas vaginalis. Conrad, M..D., Gorman, A.W., Schillinger, J.A., Fiori, P. L., Arroyo, R., Malla, N., Dubey, M.L., González, J., Blank, B., Secor, W.E and. Carlton, J.M. Article PLoS Negl Trop Dis (2012)
How to invade, replicate, and escape from host organisms. A challenge in defining virulence factors for parasites. Schenkman S, González J. Article Microbes Infect. (2012)
Metabolites from the leaf extract of Serjania yucatanensis with trypanocidal activityagainst Trypanosoma cruzi. Polanco-Hernández G, Escalante-Erosa F, García-Sosa K, Acosta-Viana K, Chan-Bacab MJ, Sagua- Franco H, González J, Osorio-Rodríguez L, Moo-Puc RE, Peña-Rodríguez LM. Article Parasitology Research (2012)
Virulence factors of Trypanosoma cruzi: who is who? Osorio L, Ríos I, Gutiérrez B, González J. Article Microbes Infect. (2012)
N,N'-Dithiobisphthalimide, a disulfide aromatic compound, is a potent spermicide agent in humans. Florez M, Díaz ES, Brito I, González J, Morales P. Article Syst Biol Reprod Med (2011)
Two new phospholipase D isoforms of Loxosceles laeta: Cloning, heterologous expression, functional characterization, and potential biotechnological application. Catalán A, Cortes W, Sagua H, González J, Article J Biochem Mol Toxicol. (2011)
Tetracycline and penicillin resistant Clostridium perfringens isolated from the fangs and venom glands of Loxosceles laeta: its implications in loxoscelism treatment. Catalán A, Espoz MC, Cortés W, Sagua H, González J, Araya JE. Article Toxicon (2010)
Effectiveness of a repellent paint against the spider Loxosceles laeta Catalan, A; Araya, JE; Varela H.; Cortes, W; Sagua, H; Gonzalez, J Article ISI REVISTA MEDICA DE CHILE (2009)
Molecular characterization and intracellular distribution of the alpha 5 subunit of Trypanosoma cruzi 20S proteasome. Gutiérrez B, Osorio L, Motta MC, Huima-Byron T, Erdjument-Bromage H, Muñoz C, Sagua H, Mortara RA, Echeverría A, Araya JE, González J. Article Parasitol Int. (2009)
Calcineurin B of human protozoan parasite Trypanosoma cruzi is involved in the cell invasión. Araya JE., Cornejo A, Cordero EM, Cortes M, Rodríguez S, Neira I, Santos MR, Sagua H, da Silveira JF, Yoshida, N and González J Article Microbes and Infection. (2008)
Descenlace fatal por loxoscelismo cutáneo visceral. Zambrano, A., González, J. y Callejas, G. Article Rev. Med. Chile (2005)
A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi. González J, Cornejo A, Santos MR, Cordero EM, Gutierrez B, Porcille P, Mortara RA, Sagua H, Da Silveira J, Araya JE Article Biochem J. (2003)
Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi. Araya JE, Neira I, da Silva S, Mortara RA, Manque P, Cordero E, Sagua H, Loyola A, Borquez J, Morales G, González, J. Article Mem Inst Oswaldo Cruz (2003)
Azorellane diterpenoids from Lareta acaulis, and its toxoplasmacidal activity Loyola, LA; Bórquez J.; Morales G.; Araya J.; Gonzalez, J; Neira, I; Sagua, H; San Martin, A Article ISI BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA (2001)
Diterpenoids from Azorella yareta and their trichomonicidal activities Loyola, L.A., Bórquez, J., Morales, G., Araya, J., González, J., Neira, I., Sagua, H., San-Martin, A. Article Phytochemistry (2001)
La enseñanza de postgrado en la Facultad de Ciencias de la Salud. González, J. Article Rev. Ciencia Salud. (2001)
Nuevos casos de infección humana por Diphyllobothrium pacificum (Nybelin, 1931) Margolis, 1956 in el Norte de Chile, probablemente relacionados con el fenómeno de El Niño, 1975-2000. Sagua, H., Neira, I., Araya, J y González, J. Article Bol. Chil. Parasitol (2001)
The ubiquitin-proteasome pathway plays an essential role in proteolysis during Trypanosoma cruzi remodeling de Diego, JL; Katz, JM; Marshall, P; Gutierrez, B; Manning, JE; Nussenzweig, V; Gonzalez J. Article BIOCHEMISTRY (2001)
Diphyllobothriosis humana por infección por Diphyllobothrim pacificum en un niño de 3 años en Antofagasta. Sagua, H., Aliaga, P., Neira, I., Araya, J., González, J. Article Rev. Chil. Pediatr. (2000)
Fosforilación en células eucarióticas. Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas. González, J. Article Rev. Med. Chil (2000)
Mepraia spinolai in the southeastern pacific ocean coast (Chile)-First insular record and feeding pattern on the Pan de Azúcar Island. Sagua Franco, H., Araya Rojas, J., González, J., Neira Cortés, I. Article Mem. Inst. Oswaldo Cruz. (2000)
Enteroparasitosis in the north of Chile. II. Coproparasitological survey in children of altiplanic communities. Araya, J., González, J. and Sagua, H. Article Rev. Chil. Tec. Med (1998)
Proteosomes, un complejo enzimático multicatalítico en busca de nuevas funciones. González, J. Article Rev.Ciencia y Salud (1998)
Proteasome function is required for encystation of Entamoeba invadens González, J., Frevert, U., Corey, E.J., Nussenzweig, V and Eichinger, D. Article Arch. Med. Res. (1997)
Vigilancia serológica de la transmisión congénita de la enfermedad de Chagas en Antofagasta-Chile. Neira, I., Arancibia, A.M., Lorca, M., Veloso, C., Varela, H., González, J y Sagua, H. Article Rev. Ciencia y Salud. (1997)
Anti- gal antibodies in chilean population infected by Trypanosoma cruzi. González, J., Ramírez, C., Seguel, J., Gutiérrez, B., Manque, P., Neira, I. and Sagua, H. Article Bol. Chile.Parasitol. (1996)
Proteasome activity is required for the stage-specific transformation of a protozoan parasite. González, J., Ramalho-Pinto, F.J., Frevert, U., Ghiso, J., Tomlinson, S., Scharfstein, J., Corey, E.J. and Nussenzweig, V. Article J. Exp. Med. (1996)
Serum antibodies to Trypanosoma cruzi antigen in atacamenos patients from highlands of northern. González, J., Neira, I., Gutiérrez, B., Anacona , D., Manque, P., Silva, J., Marin, S., Sagua, H. and Vergara U. Article Acta .Trop (1996)
Biochemical, immunological and biological characterization of Trypanosoma cruzi populations of the Andean north of Chile. González, J., Muñoz, S., Ortiz, S., Anacona, D., Salgado, S., Galleguillos, M., Neira, I., Sagua, H. and Solari, A. Article Exp. Parasitol. (1995)
Chagas’ disease in northern Chile. Serological prevalence in pregnance women from Antofagasta city, 1991-1993. Arancibia, A.M., Sagua, H., Neira, I., González, J and Varela H. Article Bol. Chil. Parasitol. (1995)
The 35/50 kDa surface antigen of Trypanosoma cruzi metacyclic trypomastigote, an adhesion molecule involved in host cell invasion. Ruiz, R., Rigoni, V.L., González, J. and Yoshida, N. Article Parasite. Immunol. (1995)
Participation of antibodies in the protection against Trypanosoma cruzi infection. González, J. and Yoshida, N. Article Rev. Chil. Cs. Med. Biol (1992)
Algunas reflexiones acerca de la investigación cientifica en las universidades derivadas. González, J. Article Rev.Chil. Cs. Méd. Biol (1992)
In vitro activity of natural products against the trypomastigote forms of Trypanosoma cruzi González, J., Sagua, H., Araya, J., Loyola, A., Morales, G., Pereira, J. and Estrada, M Article Phytoter. Research. 4: (1991)
Resistance to acute Trypanosoma cruzi infection resulting from immunization of mice with a 90-kilodalton antigen from metacyclic trypomastigote González, J., Araguth, M. and Yoshida, N. Article Infect. Immun. (1991)
Proteosome-dependent cyst formation and stage-specific ubiquitin mRNA accumulation in Entamoeba invadens. González, J., Frevert, U., Corey, E. J., and Eichinger, D Article Eur.J. Biochem. (1990)
The stage-specific 90 kilodalton surface antigen of metacyclic trypomastigotes of Trypanosoma cruzi Yoshida, N., Blanco, S.A. , Araguth, M., Russo, M. and González, J. Article Mol. Biochem. Parasitol. (1990)
Metacyclic neutralizing effect of monoclonal antibody 10D8 directed to the 35 and 50 kilodalton surface glycoconjugate of Trypanosoma cruzi Yoshida, N., Mortara, R., Araguth , González, J. and Russo, M Article Infec.Immun. 57: (1989)
A new method for the aethiological diagnosis of human scabies. Castro, D., González, J., Sagua, H., Araya, J. and Wageman, R. Article Bol. Chile. Parasitol. (1987)
Chagasic cardiomyopathy in Chilean highland. Apt, W., Arribada, A., Sagua, H., González, J. and Araya, J. Article Rev. Med. Chile. (1987)
Cryptosporidiosis in the north of Chile. I. Prevalence in domestic, synantropic and wild animals. Araya, J., González, J., Sagua, H., Olivares, W., Rimassa, C. and Videla, M. Article Bol. Chile. Parasitol (1987)
Cryptosporidiosis in the north of Chile. II Prevalence in infants with acute diarrhea. Araya, J., Hartard, M., Sagua, H., González, J., Arriagada, J. and Palma, J. Article Bol. Chil. Parasitol. (1987)
First report of Anisakis simplex (Rudolphi, 1809, det Krabbe 1878) from the dolphin Tursiops truncatus (Montagu, 1821), stranded at Antofagasta, Chile. Sagua, H., Guerra, C.G., González, J., Araya, J., Luna, G., and Portflitt, G. Article Parasitol. al Dia (1987)
Trypanosoma cruzi infection among habitants of non Andean plateau areas in the second region-Antofagasta (1983-1985). González, J., Araya, J., Sagua, H., Cornejo, J. and Vargas, L. Article Rev. Chil. Tec. Med (1987)
An evaluation of the direct agglutination test for diagnosis of Chagas’ disease. González, J., Araya, J., Sagua, H., Miranda, N., Garcia, C. and Mancilla, E. Article Parasitol . al Dia (1986)
Chagas’ disease in Chile. Seroepidemiological study in 5 blood banks from the II region, Antofagasta. Antofagasta -1985 Araya, J., González, J., Sagua, H., Cornejo, J., and Vargas, L. Article Parasitol .al. Dia. (1986)
ELISA test for the diagnosis of American trypanosomiasis. Limit absorbances for reacting and non reacting sera. González, J., Olivares, H., Araya, J. and Sagua, H. Article Bol. Chile. Parasitol. (1986)
Enteroparasitosis in the north of Chile. I. Prevalence in fishers of several port of the II region. Antofagasta. González, J., Araya, J., Sagua, H. and Beltrán, R. Article Rev. Chil. Tec. Med. (1985)
Yielding of SAF method modification for enteroparasitological diagnosis. González, J., Araya, J., Sagua, H. and Fuentes, A. Article Rev. Chil.. Tec. Med. (1985)
Yielding of the indirect hemagglutination test for the diagnosis of Chagas’ disease in sera and filter paper eluates González, J., Sagua, H., Araya, J. and Fuentes, A. Article Bol. Chile. Parasitol (1985)
Diagnosis of trichomoniasis: Evaluation of techniques for collection and transport of samples. Sagua, F., Fuentes, A., Raby, M., González, J., and Araya, J. Article Rev. Med. Chil. (1983)
Epidemiological survey of toxoplasmosis by an intradermal test in universitary students Araya, J., González, J., Sagua, H. and Fuentes, A. Article Bol. Chile. Parasitol (1983)
Chagasic seropositivity in a blood bank in a endemic area. Some epidemiological aspects of the blood donors. Sagua, H., Araya, J., González, J., and Fuentes, A. Article Bol. Chile. Parasitol. (1982)
Enteroparasitological survey among foods manipulators in Antofagasta city. Fuentes, A., Sagua, H., Araya, J., and González, J. Article Rev. Chil. Tec. Med. (1981)


POPULATION GENOMICS OF TRICHOMONAS VAGINALIS REVEALS A GLOBALLY DISTRIBUTED TWO-PHYLOTYPE POPULATION STRUCTURE Conrad, M; Gorman, A; Schilinger, J; Sullivan, S.; Upcroft, J; Gonzalez, J; Fiori, PL; Arroyo, R; Ravel, J; Secor, E; Carlton, J Abstract ISI SEXUALLY TRANSMITTED INFECTIONS (2011)
POPULATION GENOMICS OF THE SEXUALLY TRANSMITTED HUMAN PATHOGEN TRICHOMONAS VAGINALIS Conrad, MD; Zubacova, Z; Schillinger, J; Secor, WE; Upcroft, J; Gonzalez, J; Arroyo, R; Sullivan, S.; Carlton, JM Abstract ISI AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2010)
The COP9 signalosome of Trypanosoma cruzi Vega, JL; Araya, JE; Sagua, H; Gonzalez, J Abstract ISI PLACENTA (2006)


Role of Proteomics in the Study of Trypanosoma cruzi San Francisco Juan,; Gutiérrez Bessy; Gonzalez, Jorge Alejandro; de Souza, Wanderley BookSection El libro existe en versión impresa y como ebook (2019)


Nuevos casos de infección humana por Diphyllobothrium pacificum (Nybelin, 1931) Margolis, 1956 en Chile y su probable relación con el fenómeno de El Niño, 1975-2000 Sagua, Hernan; Neira, Ivan; Araya, Jorge; González, Jorge ComunicacionBreve SCIELO BOLETIN CHILENO DE PARASITOLOGIA (2001)


Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites Munoz, C; Francisco, JS; Gutierrez B.; Gonzalez, J Review ISI SCOPUS BioMed Research International (2015)
Role of Gap Junctions and Hemichannels in Parasitic Infections Vega, JL; Subiabre, M; Figueroa F.; Schalper, KA; Osorio, L; Gonzalez, J; Sáez JC Review ISI SCOPUS BioMed Research International (2013)
Phosphorylation in eukaryotic cells. Role of phosphatases and kinases in biology, pathogenesis and control of intracellular and bloodstream protozoa Gonzalez, J Review ISI REVISTA MEDICA DE CHILE (2000)