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Cristhian Alejandro Urzúa Salinas

Director

Laboratorio de Enfermedades Autoinmunes Oculares y Sistémicas. Universidad de Chile

Santiago, Chile

Ocular immunology; Uveitis; Vogt-Koyanagi-Harada disease; Retina; Stem Cells; Dry Eye Syndrome

Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
Especialista en Oftalmologia, UNIVERSIDAD DE CHILE. Chile, 2010
Magister en Inmunologia, UNIVERSIDAD DE CHILE. Chile, 2014
Postdoctoral Fellowship in Clinical Immunology, NATIONAL INSTITUTE OF HEALTH. Estados Unidos, 2015
Retina and Uveitis Clinical Fellowship, UNIVERSITY OF BRISTOL. Reino Unido, 2016
Retina and Uveitis Clinical Fellowship, MOORFIELDS EYE HOSPITAL. Reino Unido, 2018

Profesor Asociado Part Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2010 - At present

Oftalmologo Part Time

Clinica Alemana

Santiago, Chile

2018 - At present

Docente de pregrado y de postgrado de Oftalmologia. Facultad de Medicina. Universidad de Chile.
Director de Tesis de Pregrado de Alumnos de Tecnologia Médica y de Ingenieria Comercial, Universidad de Chile.

Gillingham Fellowship

Asociación Panamericana de Oftalmología

Chile, 2014

Se otorga a oftalmólogo latinoamericano para la realización de estudios de especialización en el extranjero.
Premio Liderazgo

Asociación Panamericana de Oftalmología

Chile, 2011

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Definition of Uveitis Refractory to Treatment: A Systematic Review in the Absence of a Consensus Valenzuela, Rodrigo A.; Flores, Ivan; Pujol, Myriam; Llanos, Carolina; Carreno, Ester; Rada, Gabriel; Herbort, Carl P., Jr.; Cuitino, Loreto; Urzua, Cristhian A. Article ISI OCULAR IMMUNOLOGY AND INFLAMMATION (2020)
Initial-onset acute and chronic recurrent stages are two distinctive courses of Vogt-Koyanagi-Harada disease Urzua, Cristhian A.; Herbort, Carl, Jr.; Valenzuela, Rodrigo A.; Abu El-Asrar, Ahmed M.; Arellanes-Garcia, Lourdes; Schlaen, Ariel; Yamamoto, Joyce; Pavesio, Carlos Article ISI JOURNAL OF OPHTHALMIC INFLAMMATION AND INFECTION (2020)
New Pharmacological Strategies for the Treatment of Non-Infectious Uveitis. A Minireview Valenzuela, Rodrigo A.; Flores, Ivan; Urrutia, Beatriz; Fuentes, Francisca; Sabat, Pablo E.; Llanos, Carolina; Cuitino, Loreto; Urzua, Cristhian A. Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Diabetes MellitusAssociated Uveitis: Clinical Features in a Chilean Series Sabat P.E.; Anguita R.; Saez V.; Morales S.; UrzÃºa C.A.; Villarroel F.A.; VelÃ¡squez V. Article SCOPUS Ocular Immunology and Inflammation (2019)
Glucocorticoid Receptor-alpha and MKP-1 as Candidate Biomarkers for Treatment Response and Disease Activity in Vogt-Koyanagi-Harada Disease Urzua, Cristhian A.; Chen, Ping; Chaigne-Delalande, Benjamin; Liu, Baoying; Anguita, Rodrigo; Guerrero, Julia; Sabat, Pablo; Velasquez, Victor; Sen, H. Nida; Lee, Richard W. J.; Goecke, Annelise Article ISI SCOPUS AMERICAN JOURNAL OF OPHTHALMOLOGY (2019)
Clinical Features and Prognostic Factors in Presumed Ocular Tuberculosis Urzua C.A.; Lantigua Y.; Abuauad S.; Liberman P.; Berger O.; Sabat P.; Velasquez V.; Castiglione E.; Calonge M. Article ISI SCOPUS CURRENT EYE RESEARCH (2017)
Evaluation of the Accuracy of T-SPOT.TB for the Diagnosis of Ocular Tuberculosis in a BCG-vaccinated, Non-endemic Population Urzua C.A.; Liberman P.; Abuauad S.; Sabat P.; Castiglione E.; Beltran-Videla M.A.; Aguilera R. Article ISI SCOPUS OCULAR IMMUNOLOGY AND INFLAMMATION (2017)
Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease Urzua, Cristhian A.; Guerrero, Julia; Gatica, Hector; Velasquez, Victor; Goecke, Annelise Article ISI SCOPUS INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2017)
Efficacy of a fixed combination of 0.09 % xanthan gum/0.1 % chondroitin sulfate preservative free vs polyethylene glycol/propylene glycol in subjects with dry eye disease: a multicenter randomized controlled trial Perez-Balbuena, A.L.; Ochoa-Tabares, J.C.; Belalcazar-Rey, S.; Urzua, Cristhian A.; Saucedo-Rodriguez, L.R.; Velasco-Ramos, R.; Suarez-Sanchez, R.G.; Rodriguez-Carrizalez, A.D.; Oregon-Miranda, A.A. Article ISI SCOPUS BMC OPHTHALMOLOGY (2016)
Elevated CD1c(+) Myeloid Dendritic Cell Proportions Associate With Clinical Activity and Predict Disease Reactivation in Noninfectious Uveitis Chen, P.; Urzua C.A.; Knickelbein J.E.; Kim, J. S.; Li Z.; Hannes S.; Kuo D.; Chaigne-Delalande B.; Armbrust K.; Tucker W.; Liu, B; Agrón E.; Sen H.N.; Nussenblatt R.B. Article ISI SCOPUS INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2016)
Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice Ezquer, M; urzua c; Montecino, S; Leal, K; Conget P.; Ezquer, Fernando Article ISI SCOPUS STEM CELL RESEARCH & THERAPY (2016)
Causes of Uveitis in a Tertiary Center in Chile: A Cross-sectional Retrospective Review Liberman P; GAURO F; Berger O; Urzua, CA Article ISI SCOPUS Ocular Immunology and Inflammation (2015)
Earlier immunomodulatory treatment is associated with better visual outcomes in a subset of patients with Vogt-Koyanagi-Harada disease Urzua, CA; Velasquez V.; Sabat P.; Berger O; Ramirez, S.; Goecke, A; Vasquez, DH; Gatica H.; Guerrero, J Article ISI SCOPUS Acta Ophthalmologica (2015)
Enfermedad de Vogt-Koyanagi-Harada Urzua-Salinas, Cristhian Alejandro; Abauad, Sergio Article Ciencia Oftalmológica (2013)
Randomized Double-Blind Clinical Trial of Autologous Serum Versus Artificial Tears in Dry Eye Syndrome Urzua C.A.; Vasquez D.H.; Huidobro A.; Hernandez, H; Alfaro, J Article ISI SCOPUS Current Eye Research (2012)


Expression kinetics of Glucocorticoid Receptor lsoforms Predicts Treatment Response to Glucocorticoids in Uveitis patients Urzua, CA; Si, H; Liu, BY; Lait, P; Lee, RWJ; Goecke, A; Nussenblatt, RB Abstract ISI INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)
INTRAVITREAL ADMINISTRATION OF MULTIPOTENT MESENCHYMAL STROMAL CELLS INCREASES NEUROTROPHIC FACTORS LEVELS, REDUCES OXIDATIVE DAMAGE AND PREVENTS RETINAL NEURONAL CELL LOSS IN DIABETIC MICE Montecino, S; Leal, K; urzua c; Ezquer, M; Conget P.; Ezquer, F Abstract ISI CYTOTHERAPY (2015)


Vogt-Koyanagi-Harada Disease Urzua-Salinas, Cristhian Alejandro; Foster, Stephen; Rodriguez-Garcia, Alejandro BookSection (2019)


Kit for predicting treatment with glucocorticoids, and method comprising same Universidad de Chile Patent Patent Pending
Method for packaging amniotic membrane Urzua, CA Patent patent pending


Asociación de la ancestría y polimorfismo genético con el riesgo de padecer la enfermedad Vogt-Koyanagi-Harada en población chilena Urzua-Salinas, Cristhian Alejandro Proyecto (2019)
Evaluación de la frecuencia, severidad e impacto en la calidad de vida de las manifestaciones oftalmológicas y la toxicidad ocular asociada a hidroxicloroquina en pacientes con Lupus: Estudio Multicéntrico para generar recomendaciones clinicas nacionales Urzua-Salinas, Cristhian Alejandro; Llanos M, Carolina Proyecto (2019)
Test de predicción rápida de respuesta a tratamiento con glucocorticoides en pacientes con Uveítis. FONDEF (IT117/0087) Proyecto 2018-2020 Director(a)
Red de Investigación Colaborativa en Oftalmología Y Ciencias Visuales Vicerrectoría de Investigación y Desarrollo. Universidad de Chile (CE-560872) Proyecto 2015-2016 Director(a)
Donor multipotent mesenchymal stromal cells modify the natural evolution of retinal damage in diabetic mice FONDEF (1130470) Proyecto 2013-2015 Coinvestigador(a)
Inmunidad Antitumoral en Neoplasias Intraoculares Oficina de Apoyo a la Investigacion Clinica (OAIC). Hospital Clinico de la Universidad de Chile Proyecto 2012-2014 Inv. Principal


Ocular syphilis: Ten new cases and review of the literature Romero P.; urzua c; Gallardo, P; Verdaguer J.; Lechuga, M.; Hernandez, H; Sanhueza, F; Andaur M.; Donaire, E Review ISI REVISTA CHILENA DE INFECTOLOGIA (2010)