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Mario Francis Rivera Meza

Profesor Asociado

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Alcoholism; Gene Therapy; Pharmacology; Alcohol intake; Drug Dependence; Gene Therapy of Alcoholism; Mechanisms of Alcohol Addiction; Vectors for Gene Therapy; Farmacologia (Neurofarmacologia); Neuroquimica; Neurociencias; Alcoholism, animal models and interventions in humans; Mechanism of alcohol actions; Gene delivery and phage display libraries

Educación

  •  Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 1998
  •  Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2009
  •  Diplomado en Innovación y Docencia Universitaria, UNIVERSIDAD DE CHILE. Chile, 2019
  •  Análisis Instrumental Orgánico , UNIVERSIDAD DE CHILE. Chile, 2025

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2015 - A la fecha

  •   Investigador Postdoctoral Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2010 - 2015

Experiencia Profesional

  •   Director Tecnico Full Time

    Farmacias Cruz Verde

    Santiago, Chile

    1999 - 2004

Formación de Capital Humano


no info


Difusión y Transferencia


No info


Premios y Distinciones

  •   Mejor Profesor Pregrado

    UNIVERSIDAD DE CHILE

    Chile, 2025

    Reconocimiento al mejor alumno de pregrado en la Facultad de cienciasQuímicas y Farmacéuticas

  •   Premio Jorge Mardones Restat

    SOCIEDAD DE FARMACOLOGIA DE CHILE

    Chile, 2009

    Premio entregado a la mejor investigación en Farmacología por estudiantes de posgrado.


 

Article (33)

Fenofibrate restores glutamatergic and dopaminergic homeostasis in the nucleus accumbens and reduces alcohol relapse in rats

Isla, Eduardo; Gutierrez-Vega, Ignacio; Quilaqueo, Maria Elena; Herrera-Marschitz, Mario; Quintanilla, Maria Elena; Morales, Paola; Perez-Reytor, Diliana; Rivera-Meza, Mario; Karahanian, Eduardo

Article ISI
FRONTIERS IN PHARMACOLOGY  (2026)

Blockade of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels reduces alcohol-induced dopamine release and reward in rats

Gutiérrez-Vega; I.; Schneider; I.; Cáceres; C.; Herrera-Marschitz; M.; Romanelli; M.N.; Morales; P.; Quintanilla; M.E.; Vasquez; D.; Rivera-Meza; M

Article ISI SCOPUS
Life Sciences  (2025)

Early-life exposure to sex hormones promotes voluntary ethanol intake in adulthood. A vulnerability factor to drug addiction.

Venegas, Francisca C.; Renard, Georgina M.

Article ISI SCOPUS
Progress in Neuro-Psychopharmacology and Biological Psychiatry  (2024)

Pharmacological activators of ALDH2: A new strategy for the treatment of alcohol use disorders

Adasme-Reyes; S.; Fuentes; J.; Gutiérrez-Vega; I.; Isla; E.; Pérez; V.; Ponce; C.; Quilaqueo; M.E.; Herrera-Marschitz; M.; Quintanilla; M.E.; Vasquez; et al.

Article ISI SCOPUS
International Review of Neurobiology  (2024)

ALDH2 inhibition by lead and ethanol elicits redox imbalance and mitochondrial dysfunction in SH-SY5Y human neuroblastoma cell line: Reversion by Alda-1

Deza-Ponzio, R; Albrecht, PA; Fernandez-Hubeid, LE; Eichwald, T; Cejas, RB; Garay, YC; Rivera-Meza M.; Latini, A; Irazoqui, FJ; Virgolini, MB

Article ISI SCOPUS
NeuroToxicology  (2023)

Neuroprotective Activity of Enantiomers of Salsolinol and N-Methyl-(R)-salsolinol: In Vitro and In Silico Studies

Kurnik-Lucka, M; Latacz, G; Bucki, A; Rivera-Meza M.; Khan N.; Konwar, J; Skowron, K; Kolaczkowski, M; Gil, K

Article ISI SCOPUS
ACS Omega  (2023)

Overexpression of wild type glycine alpha 1 subunit rescues ethanol sensitivity in accumbal receptors and reduces binge drinking in mice

Araya, Anibal; Gallegos, Scarlet; Maldonado, Adolfo; Rivera-Meza, Mario; Chandra, Ramesh; Lobo, Mary Kay; Aguayo, Luis G.

Article ISI SCOPUS
Neuropsychopharmacology  (2023)

Reduction of nicotine and ethanol intake in alcohol-preferring (UChB) female rats by the α482 nicotinic acetylcholine receptor partial agonists 5-bromocytisine and cytisine

Cassels, Bruce K.

Article ISI SCOPUS
Drug and Alcohol Dependence  (2023)

Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition

Clayton, Natasha S.; Catalán, Mabel; Ridley, Anne J.; Vivar, Raul; Diego Maya, Juan

Article ISI SCOPUS
Frontiers in Immunology  (2023)

The administration of Alda-1, an activator of ALDH2, inhibits relapse-like ethanol intake in female alcohol-preferring UChB rats

Quilaqueo M.E.; Adasme, S; Solís-Egaña, F; Quintanilla M.E.; Vasquez D.; Morales P.; Herrera-Marschitz M.; Rivera-Meza M.

Article ISI SCOPUS
Life Sciences  (2023)

Gene knockdown of HCN2 ion channels in the ventral tegmental area reduces ethanol consumption in alcohol preferring rats

Salinas-Luypaert C.; Sáez-Cortez F.; Quintanilla M.E.; Herrera-Marschitz M.; Rivera-Meza M.

Article ISI SCOPUS
American Journal of Drug and Alcohol Abuse  (2022)

UFR2709, an Antagonist of Nicotinic Acetylcholine Receptors, Delays the Acquisition and Reduces Long-Term Ethanol Intake in Alcohol-Preferring UChB Bibulous Rats

GONZÁLEZ-GUTIÉRREZ, JUAN PABLO; Quilaqueo, Maria Elena

Article ISI SCOPUS
Biomedicines  (2022)

Fenofibrate -a PPAR alpha agonist- increases alcohol dehydrogenase levels in the liver: implications for its possible use as an ethanol-aversive drug

Karahanian, Eduardo

Article ISI SCOPUS
Adicciones  (2020)

Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism?

Lagos D.; Rojas B.

Article ISI SCOPUS
NEUROPHARMACOLOGY  (2019)

Molecular modeling of salsolinol, a full G(i) protein agonist of the mu-opioid receptor, within the receptor binding site

Berríos-Cárcamo P.

Article ISI SCOPUS
CHEMICAL BIOLOGY & DRUG DESIGN  (2019)

Molecular modeling of salsolinol, a full Gi protein agonist of the μ-opioid receptor, within the receptor binding site



Article ISI
CHEMICAL BIOLOGY AND DRUG DESIGN  (2019)

Silencing brain catalase expression reduces ethanol intake in developmentally-lead-exposed rats

Mattalloni, MS; Albrecht, PA; Deza-Ponzio, R; Cancela, LM; Virgolini, MB

Article ISI SCOPUS
NEUROTOXICOLOGY  (2019)

UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats



Article ISI
FRONTIERS IN PHARMACOLOGY  (2019)

Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats

Quiroz, Gabriel; Guerra-Díaz, Nicolás

Article ISI SCOPUS
BEHAVIOURAL BRAIN RESEARCH  (2018)

Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line

Rivera-Meza, Mario; Quintanilla, Mar?a E.

Article ISI SCOPUS
FRONTIERS IN BEHAVIORAL NEUROSCIENCE  (2017)

Fenofibrate Administration Reduces Alcohol and Saccharin Intake in Rats: Possible Effects at Peripheral and Central Levels

Rivera-Meza, Mario; Jerez, Erik; Salinas-Luypaert, Catalina

Article ISI SCOPUS
FRONTIERS IN BEHAVIORAL NEUROSCIENCE  (2017)

Racemic Salsolinol and its Enantiomers Act as Agonists of the mu-Opioid Receptor by Activating the Gi Protein-Adenylate Cyclase Pathway

Herrera-Marschit M.; Vasiliou V.

Article ISI SCOPUS
FRONTIERS IN BEHAVIORAL NEUROSCIENCE  (2017)

(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake

Quintanilla, ME; Rivera-Meza, M; Berrios-Carcamo, P; Cassels, BK; Herrera-Marschitz, M; Israel, Y

Article ISI SCOPUS
ADDICTION BIOLOGY  (2016)

Beyond the "First Hit": Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation

Quintanilla M.E.; Israel Y.

Article ISI SCOPUS
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH  (2016)

Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats

Karahanian E.; Rivera-Meza M.; Tampier, L; Quintanilla M.E.; Herrera-Marschitz M.; Israel Y.

Article ISI SCOPUS
ADDICTION BIOLOGY  (2015)

Overexpression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels into the Ventral Tegmental Area Increases the Rewarding Effects of Ethanol in UChB Drinking Rats

Rivera-Meza M.; Bustamante D.; Delgado R.; Buscaglia M.; Herrera-Marschitz M.

Article ISI SCOPUS
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH  (2014)

Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake

Rivera-Meza M.; Berrios-Cárcamo, PA; Bustamante D.; Buscaglia M.; Morales P.; Karahanian E.; Herrera-Marschitz M.; Israel Y.

Article ISI SCOPUS
ALCOHOL  (2014)

The Alcohol Deprivation Effect: Marked Inhibition by Anticatalase Gene Administration into the Ventral Tegmental Area in Rats

Tampier, L; Karahanian E.; Rivera-Meza M.; Herrera-Marschitz M.; Israel Y.

Article ISI SCOPUS
Alcoholism: Clinical and Experimental Research  (2013)

Reduction of Ethanol Consumption in Alcohol-Preferring Rats by Dual Expression Gene Transfer

Rivera-Meza M.; Quintanilla M.E.; Tampier, L

Article ISI SCOPUS
Alcohol and Alcoholism  (2012)

Reward and Relapse: Complete Gene-Induced Dissociation in an Animal Model of Alcohol Dependence

Quintanilla M.E.; Tampier, L; Karahanian E.; Rivera-Meza M.; Herrera-Marschitz M.; Israel Y.

Article ISI SCOPUS
Alcoholism: Clinical and Experimental Research  (2012)

Acetaldehyde Burst Protection of ADH1B*2 Against Alcoholism: An Additional Hormesis Protection Against Esophageal Cancers Following Alcohol Consumption?

Israel Y.; Rivera-Meza M.; Sapag A.; Tampier, L

Article ISI SCOPUS
Alcoholism: Clinical and Experimental Research  (2011)

Ethanol as a Prodrug: Brain Metabolism of Ethanol Mediates its Reinforcing Effects

Karahanian E.; Tampier, L; Rivera-Meza M.; Bustamante D.; Gonzalez-Lira, V; Morales P.; Herrera-Marschitz M.; Israel Y.

Article ISI SCOPUS
Alcoholism: Clinical and Experimental Research  (2011)

Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model

Rivera-Meza M.; Tampier, L; Mura, CV; Sapag A.; Israel Y.

Article ISI SCOPUS
FASEB Journal  (2010)

BookSection (1)

The Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion Channels in the Rewarding Effects of Ethanol

Preedy, Victor

BookSection
 (2019)

Letter (1)

PPAR? agonists reduce alcohol drinking: Do they act in the brain or in the liver?

Karahanian E.; Quintanilla M.E.; Munoz D.; Fernández K.; Israel Y.

Letter ISI SCOPUS
Alcohol and Alcoholism  (2015)

Proyecto (1)

A common mechanism for alcohol- and nicotine-use disorders: translational options

Vasquez, David Reinaldo; Mario Herrea-Marschitz

Proyecto
 (2020)

Review (3)

Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options

Quintanilla M.E.

Review ISI SCOPUS
GENE THERAPY  (2019)

The "First Hit" Toward Alcohol Reinforcement: Role of Ethanol Metabolites

Israel Y.; Karahanian E.; Rivera-Meza M.; Herrera-Marschitz M.

Review ISI SCOPUS
Alcoholism: Clinical and Experimental Research  (2015)

Gene specific modifications unravel ethanol and acetaldehyde actions

Israel Y.; Rivera-Meza M.; Karahanian E.; Tampier, L; Morales P.; Herrera-Marschitz M.

Review ISI SCOPUS
Frontiers in Behavioral Neuroscience  (2013)

2
Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

8
Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

6
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

1
Ricardo Delgado

Profesor Adjunto

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGIA

Santiago, Chile

8
Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

2
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

2
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

1
Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

11
María Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

4
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

11
Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

39
Mario Rivera

Profesor Asociado

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

9
Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

1
Mabel Catalán

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Renatto Anfossi

Jefe de Investigación

Departamento de Investigación

Hospital Regional Libertador Bernardo O'Higgins

Rancagua, Chile

1
Georgina Renard

Associate professor - Directora CIBAP

School of Medicine

Universidad de Santiago de Chile

Santiago, Chile

1
Christian Castillo

Profesor Asistente

Instituto Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

2
Marianne Buscaglia

Postdoc

Genética Molecular y Microbiología

Centro de Modelamiento Matemático

Santiago, Chile

1
Gabriel Quiroz

2
Katia Fernández

Académico - Profesor Asociado

Facultad de Salud y Odontología

Universidad Diego Portales

Santiago, Chile

2
Eduardo Isla

1
Juan González

Profesor Investigador

Departamento de Física y Química

Universidad Autónoma de Chile

Talca, Chile

4
Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

1
Scarlet Gallegos

1
Fabiola González

Investigadora Postdoctoral

Universidad de Chile

Santiago, Chile

1
Gabriel Galvez

Asistente de investigacion

Escuela de ingenieria

Universidad de O'Higgins

RAncagua, Chile

1
Daniela Guzmán

Docente

Escuela de Química y Farmacia

Universidad Andrés Bello

Santiago, Chile