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Mario Francis Rivera Meza

Profesor Asistente

Universidad de Chile

Santiago, Chile

Alcoholism; Gene Therapy; Pharmacology; Alcohol intake; Drug Dependence; Gene Therapy of Alcoholism; Mechanisms of Alcohol Addiction; Vectors for Gene Therapy; Farmacologia (Neurofarmacologia); Neuroquimica; Neurociencias; Alcoholism, animal models and interventions in humans; Mechanism of alcohol actions; Gene delivery and phage display libraries

Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 1998
Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2009
Diplomado en Innovación y Docencia Universitaria, UNIVERSIDAD DE CHILE. Chile, 2019

Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Ciencias Químicas y Farmacéuticas

Santiago, Chile

2015 - A la fecha
Investigador Postdoctoral Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2010 - 2015


Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats=> A dual mechanism? Rivera-Meza, Mario; Vásquez, David; Quintanilla, María Elena; Lagos, Diego; Rojas, Braulio; Herrera-Marschitz, Mario; Israel, Yedy Article Neuropharmacology (2019)
Fenofibrate -a PPARα agonist- increases alcohol dehydrogenase levels in the liver: implications for its possible use as an ethanol-aversive drug Article ISI ADICCIONES (2019)
Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism=> translational options. Yedy Israel, ; Quintanilla, María Elena; Ezquer, Fernando; Morales, Paola; Rivera-Meza, Mario; Karahanian, Eduardo; Ezquer, Marcelo; Herrera-Marschitz, Mario Article Gene therapy (2019)
Molecular modeling of salsolinol, a full Gi protein agonist of the μ-opioid receptor, within the receptor binding site Article ISI CHEMICAL BIOLOGY AND DRUG DESIGN (2019)
Silencing brain catalase expression reduces ethanol intake in developmentally-lead-exposed rats. Mattalloni, Mara Soledad; Albrecht, Paula Alejandra; Salinas-Luypaert, Catalina; Deza-Ponzio, Romina; Quintanilla, María Elena; Herrera-Marschitz, Mario; Cancela, Liliana Marina; Rivera-Meza, Mario; Virgolini, Miriam Beatriz Article Neurotoxicology (2019)
UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats Article ISI FRONTIERS IN PHARMACOLOGY (2019)
Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats. Quiroz, Gabriel; Guerra-Díaz, Nicolás; Iturriaga-Vásquez, Patricio; Rivera-Meza, Mario; Quintanilla, María Elena; Sotomayor-Zárate, Ramón Article Behavioural brain research (2018)
Acquisition, Maintenance and Relapse-Like Alcohol Drinking=> Lessons from the UChB Rat Line. Israel, Yedy; Karahanian, Eduardo; Ezquer, Fernando; Morales, Paola; Ezquer, Marcelo; Rivera-Meza, Mario; Herrera-Marschitz, Mario; Quintanilla, María E Article Frontiers in behavioral neuroscience (2017)
Fenofibrate administration reduces alcohol and saccharin intake in rats=> possible effects at peripheral and central levels Rivera-Meza, Mario; Muñoz, Daniel; Jerez, Erik; Quintanilla, María Elena; Salinas-Luypaert, Catalina; Fernandez, Katia; Karahanian, Eduardo Article Frontiers in Behavioral Neuroscience (2017)
Racemic Salsolinol and its Enantiomers Act as Agonists of the mu-Opioid Receptor by Activating the Gi Protein-Adenylate Cyclase Pathway. Berríos-Cárcamo, Pablo; Quintanilla, María Elena; Herrera-Marschitz, Mario; Vasiliou, Vasilis; Zapata-Torres, Gerald; Rivera-Meza, Mario Article Frontiers in Behavioral Neuroscience (2017)
(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake. Quintanilla, María Elena; Rivera-Meza, Mario; Berríos-Cárcamo, Pablo; Cassels, Bruce K; Herrera-Marschitz, Mario; Israel, Yedy Article Addiction biology (2016)
Beyond the "First Hit": Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation. Quintanilla, María Elena; Rivera-Meza, Mario; Berríos-Cárcamo, Pablo; Salinas-Luypaert, Catalina; Herrera-Marschitz, Mario; Israel, Yedy. Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2016)
Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area. Karahanian, Eduardo; Rivera-Meza, Mario; Tampier, Lutske; Quintanilla, María Elena; Herrera-Marschitz, Mario; Israel, Yedy Article ADDICTION BIOLOGY (2015)
PPAR-alpha agonists reduce alcohol drinking: do they act in the brain or in the liver? Karahanian, Eduardo; Rivera-Meza, Mario; Quintanilla, María Elena; Muñoz, Daniel; Fernández, Katia; Israel, Yedy. Article ALCOHOL AND ALCOHOLISM (2015)
The “first hit” against alcohol reinforcement: role of ethanol metabolites. Israel, Yedy; Quintanilla, María Elena; Karahanian, Eduardo; Rivera-Meza, Mario; Herrera-Marschitz, Mario. Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2015)
Overexpression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels into the Ventral Tegmental Area Increases the Rewarding Effects of Ethanol in UChB Drinking Rats Rivera-Meza, M; Quintanilla, ME; Bustamante D., Delgado; R, Buscaglia M.; Herrera-Marschitz, M Article Alcoholism=> Clinical and Experimental Research (2014)
Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake. Quintanilla, María Elena; Rivera-Meza, Mario; Berríos-Cárcamo, Pablo; Bustamante, Diego; Buscaglia, Marianne; Morales, Paola; Karahanian, Eduardo; Herrera-Marschitz, Mario; Israel, Yedy Article ALCOHOL (2014)
Gene specific modifications unravel ethanol and acetaldehyde actions. Israel, Yedy; Rivera-Meza, Mario; Karahanian, Eduardo; Quintanilla, María Elena; Tampier, Lutske; Morales, Paola; Herrera-Marschitz, Mario Article Frontiers in Behavioral Neuroscience (2013)
The alcohol deprivation effect: marked inhibition by anticatalase gene administration into the ventral tegmental area in rats. Tampier, Lutske; Quintanilla, María Elena; Karahanian, Eduardo; Rivera-Meza, Mario; Herrera-Marschitz, Mario; Israel, Yedy. Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2013)
Reduction of ethanol consumption in alcohol-preferring rats by dual expression gene transfer. Rivera-Meza, Mario; Quintanilla, María Elena; Tampier, Lutske. Article ALCOHOL AND ALCOHOLISM (2012)
Reward and relapse: complete gene-induced dissociation in an animal model of alcohol dependence. Quintanilla, María Elena; Tampier, Lutske; Karahanian, Eduardo; Rivera-Meza, Mario; Herrera-Marschitz, Mario; Israel, Yedy. Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2012)
Acetaldehyde burst protection of ADH1B*2 against alcoholism: An additional hormesis protection against esophageal cancers following alcohol consumption? Israel, Yedy; Rivera-Meza, Mario; Quintanilla, María Elena; Sapag, Amalia; Tampier, Lutske. Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2011)
Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects. Karahanian, Eduardo; Quintanilla, Maria Elena; Tampier, Lutske; Rivera-Meza, Mario; Bustamante, Diego; Gonzalez-Lira, Victor; Morales, Paola, Herrera-Marschitz, Mario; Israel, Yedy. Article ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2011)
Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model. Rivera-Meza, Mario; Quintanilla, María Elena; Tampier, Lutske; Mura, Casilda; Sapag, Amalia; Israel, Yedy Article FASEB JOURNAL (2010)


The Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion Channels in the Rewarding Effects of Ethanol Preedy, Victor BookSection (2019)


A common mechanism for alcohol- and nicotine-use disorders: translational options Vasquez, David Reinaldo; Mario Herrea-Marschitz Proyecto (2020)
Pharmacological activation of aldehyde dehydrogenase=> mechanism involved in the reduction of ethanol consumption Universidad de Chile, Facultad de Ciencias Químicas y Farmacéuticas (PII2018) Proyecto 2018-2019 Inv. Principal
A NEW PHARMACOLOGIC STRATEGY FOR THE TREATMENT OF ALCOHOLISM=> STUDIES IN ANIMAL MODELS FONDECYT (1150850) Proyecto 2015-2017 Coinvestigador(a)
REBOUND OF THE OPIATE SYSTEM AS RESPONSIBLE FOR BINGE-DRINKING IN THE ALCOHOL DEPRIVATION EFFECT. FONDECYT (11130241) Proyecto 2013-2016 Inv. Responsable
REWARDING MOLECULES GENERATED FROM ETHANOL IN THE BRAIN FONDECYT (1130012) Proyecto 2013-2016 Coinvestigador(a)
GENE SILENCING OF HCN CHANNELS AND ITS EFFECTS ON THE STIMULATING AND REWARDING EFFECTS OF ETHANOL FONDECYT (3110107) Proyecto 2010-2013 Inv. Responsable

Mario Rivera

Profesor Asistente

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

Mario Francis Rivera Meza

Líneas de Investigación

Educación

Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 1998

Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2009

Diplomado en Innovación y Docencia Universitaria, UNIVERSIDAD DE CHILE. Chile, 2019

Experiencia Académica

Profesor Asistente Full Time

Investigador Postdoctoral Full Time

Article (24)

BookSection (1)

Proyecto (6)

Pharmacological activation of aldehyde dehydrogenase=> mechanism involved in the reduction of ethanol consumption

A NEW PHARMACOLOGIC STRATEGY FOR THE TREATMENT OF ALCOHOLISM=> STUDIES IN ANIMAL MODELS

REBOUND OF THE OPIATE SYSTEM AS RESPONSIBLE FOR BINGE-DRINKING IN THE ALCOHOL DEPRIVATION EFFECT.

REWARDING MOLECULES GENERATED FROM ETHANOL IN THE BRAIN

GENE SILENCING OF HCN CHANNELS AND ITS EFFECTS ON THE STIMULATING AND REWARDING EFFECTS OF ETHANOL