Man

Hans Joseph Moldenhauer Barrientos

Académico investigador

Universidad Santo Tomás

Santiago, Chile

Líneas de Investigación


Estructura y función de canales de iones; Expresion y regulacion de canales ionicos; Biologia Molecular; Genetica

Educación

  •  Bioquimica, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2009
  •  doctorado en ciencias mención neurociencia, UNIVERSIDAD DE VALPARAISO. Chile, 2015
  •  Bioquimico, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2009
  •  ciencia mencion neurociencia, UNIVERSIDAD DE VALPARAISO. Chile, 2015

Experiencia Académica

  •   Post doc Part Time

    CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA DE VALPARAISO

    Valparaiso, Chile

    2015 - 2016

  •   Post doc Fondecyt 3160321 Other

    UNIVERSIDAD DE VALPARAISO

    Ciencias

    Valparaiso, Chile

    2016 - A la fecha

Experiencia Profesional

  •   Ayudante de Neurociencias II carrera de Psicología primer año

    Universidad de Valparaíso

    Chile

    2010 - 2010

  •   Ayudante de ciencias biomedicas carrera Ingeniería en biomedica primer año

    Universidad de Valparaíso

    Chile

    2011 - 2011

  •   Ayudante de Neurociencias II carrera de Psicología primer año

    Universidad de Valparaíso

    Chile

    2012 - 2012

  •   Ayudante de ciencias biomedicas carrera Ingeniería en biomedica primer año

    Universidad de Valparaíso

    Chile

    2012 - 2012

  •   Academico investigador Full Time

    Universidad Santo Tomas

    Santiago, Chile

    2023 - A la fecha

  •   Postdoc Full Time

    University of Maryland Baltimore

    Baltimore, Estados Unidos

    2019 - 2020

  •   Investigador asociado Part Time

    Núcleo Milenio de Enfermedades Asociadas a Canales iónicos (MiNICAD)

    Santiago, Chile

    2021 - 2023

  •   Investigador asociado Part Time

    University of Maryland Baltimore

    Santiago, Estados Unidos

    2022 - 2023

  •   Postdoc Full Time

    Universidad de Valparaiso

    Valparaiso, Chile

    2015 - 2018


 

Article (14)

BK channel properties correlate with neurobehavioral severity in three <i>KCNMA1</i>-linked channelopathy mouse models

Park, Su Mi; Roache, Cooper E.; Iffland II, Philip H.; Moldenhauer, Hans J.; Matychak, Katia K.; Plante, Amber E.; Lieberman, Abby G.; Crino, Peter B.; Meredith, Andrea

Article ISI
ELIFE  (2022)

Effect of an autism-associated<i> KCNMB2</i> variant, G124R, on BK channel properties

Moldenhauer, Hans J.; Dinsdale, Ria L.; Alvarez, Sara; Fernandez-Jaen, Alberto; Meredith, Andrea L.

Article ISI
CURRENT RESEARCH IN PHYSIOLOGY  (2022)

Comparative gain-of-function effects of the <i>KCNMA1</i>-N999S mutation on human BK channel properties

Moldenhauer, Hans J.; Matychak, Katia K.; Meredith, Andrea L.

Article ISI
JOURNAL OF NEUROPHYSIOLOGY  (2020)

Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states

Moldenhauer, Hans; Diaz-Franulic, Ignacio; Poblete, Horacio; Naranjo, David

Article ISI SCOPUS
ELIFE  (2019)

Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K+ channels

Diaz-Franulic, I; Gonzalez-Perez, V; Moldenhauer, H; Navarro-Quezada, N; Naranjo, D

Article ISI SCOPUS
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  (2018)

Effective pore size and radius of capture for K(+) ions in K-channels

Moldenhauer, H; Díaz-Franulic I; González-Nilo F; Naranjo, D

Article ISI
Scientific report  (2016)

Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six

Jabba Sairam; Goyal Raman; Sosa-Pagán Jason O; Moldenhauer Hans; Wu Jason; Kalmeta Breanna; Bandell Michael; Latorre Ramon; Patapoutian Ardem; Grandl Jörg.

Article
Neuron  (2014)

Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six.

Jabba S; Goyal, R; Sosa-Pagán JO; Moldenhauer, H; Wu J.; Kalmeta B; Bandell M; Latorre R.; Patapoutian A; Grandl J

Article ISI
NEURON  (2014)

The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole

Moldenhauer Hans; Latorre Ramon; Grandl Jörg

Article
PLOS one  (2014)

The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole.

Moldenhauer, H; Latorre R.; Grandl J

Article ISI
PLoS One  (2014)

Could an Allosteric Gating Model Explain the Role of TRPA1 in Cold Hypersensitivity?

Salazar Marcelo; Moldenhauer Hans; Baez-Nieto David.

Article
The Journal of Neuroscience  (2011)

Could an allosteric gating model explain the role of TRPA1 in cold hypersensitivity?

Salazar M.; Moldenhauer, H; Baez-Nieto, D

Article ISI
JOURNAL OF NEUROSCIENCE  (2011)

Fast and Reversible Stimulation of Astrocytic Glycolysis by K+ and a Delayed and Persistent Effect of Glutamate

Bittner Carla X; Valdebenito Rocío; Ruminot Iván; Loaiza Anitsi; Larenas Valeria; Sotelo-Hitschfeld Tamara; Moldenhauer Hans; San Martín Alejandro; Gutiérrez Robin; Zambrano Marilyn; Barros L. Felipe

Article
The Journal of Neuroscience  (2011)

Fast and reversible stimulation of astrocytic glycolysis by K+ and a delayed and persistent effect of glutamate.

bittner cx; Valdebenito, R; Ruminot, I; Loaiza A.; Larenas V; Sotelo-Hitschfeld T; Moldenhauer, H; San Martín A; Gutiérrez R; Zambrano M.; Barros, LF

Article ISI
JOURNAL OF NEUROSCIENCE  (2011)

Proyecto (1)

DETERMINATION OF THE ARCHITECTURE AND DYNAMICS OF THE VOLTAGE- AND CALCIUM-ACTIVATED (BK) CHANNEL USING LANTHANIDE RESONANCE ENERGY TRANSFER (LRET)

FONDECYT (1110430)

Proyecto
2011-2015
Tesista

Review (3)

An emerging spectrum of variants and clinical features in <i>KCNMA1</i>-linked channelopathy

Miller, Jacob P.; Moldenhauer, Hans J.; Keros, Sotirios; Meredith, Andrea L.

Review ISI
CHANNELS  (2021)

<i>KCNMA1</i>-linked channelopathy

Bailey, Cole S.; Moldenhauer, Hans J.; Park, Su Mi; Keros, Sotirios; Meredith, Andrea L.

Review ISI
JOURNAL OF GENERAL PHYSIOLOGY  (2019)

Pore size matters for potassium channel conductance

Naranjo, D; Moldenhauer, H; Pincuntureo, M; Diaz-Franulic, I

Review ISI SCOPUS
JOURNAL OF GENERAL PHYSIOLOGY  (2016)

13
Hans Moldenhauer

Académico investigador

Salud

Universidad Santo Tomás

Santiago, Chile

4
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

3
Ignacio Diaz

Profesor asistente

Centro e Bioinformatica y Biologia Integrativa

Universidad Andrés Bello

Santiago, Chile

1
Nieves Navarro

Lab Manager

Biología Molecular

Centro interdisciplinario de neurociencia de Valparaíso

Valparaíso, Chile