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David Naranjo Donoso

Profesor titular

Universidad de Valparaíso

VALPARAISO, Chile

Estructura y Funcion de los canales de iones; Reconstitucion de canales de iones; Proteinas de Membrana; Bioquimica Computacional Simulacion Molecular; Nanobiotecnologia

Ciencias, UNIVERSIDAD DE CHILE. Chile, 1991
Biologia, UNIVERSIDAD DE CHILE. Chile, 1985

Profesor Titular Full Time

UNIVERSIDAD DE VALPARAISO

Ciencias

Valparaiso, Chile

2002 - A la fecha
Investigador Titular Full Time

Universidad Nacional Autónoma de Mexico

Instituto de Fisiología Celular

DF, México

1997 - 2002

Post Doctoral researcher Full Time

State university of New York

Stony Brook, Estados Unidos

1991 - 1993
Post Doctoral researcher Full Time

Brandeis University

Boston, Estados Unidos

1993 - 1997

4 tesis de pregrado (1 en calidad de co-tutor)
4 tesis de magister/maestria (3 en calidad de co-tutor)
4 tesis de Doctorado (1 en calidad de co-tutor)
4 guia postdoctoral


Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states Moldenhauer, Hans; Diaz-Franulic, Ignacio; Poblete, Horacio; Naranjo, David Article ISI SCOPUS ELIFE (2019)
Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K+ channels Diaz-Franulic, I; Gonzalez-Perez, V; Moldenhauer, H; Navarro-Quezada, N; Naranjo, D Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Effective pore size and radius of capture for K+ ions in K-channels Moldenhauer, H; Diaz-Franulic, I; Gonzalez-Nilo, F; Naranjo, D Article ISI SCOPUS Scientific Reports (2016)
Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels Diaz-Franulic, I; Sepulveda, RV; Navarro-Quezada, N; Gonzalez-Nilo, F; Naranjo, D Article ISI SCOPUS Journal of General Physiology (2015)
Zebrafish Ca(V)2.1 Calcium Channels Are Tailored for Fast Synchronous Neuromuscular Transmission Naranjo, D; Wen, H; BREHM, P Article ISI SCOPUS Biophysical Journal (2015)
Hypothyroidism in the Adult Rat Causes Incremental Changes in Brain-Derived Neurotrophic Factor, Neuronal and Astrocyte Apoptosis, Gliosis, and Deterioration of Postsynaptic Density Cortes C.; Eugenin, E; Aliaga, E; Carreño L.J.; Bueno, S. M.; González P.A.; Gayol S.; Naranjo, D; Noches, V; Marassi M.P.; Rosenthal, D; Jadue C.; Ibarra P.; Keitel C.; Wohllk N.; Court, F; Kalergis, A.M.; Riedel, C. A. Article ISI SCOPUS Thyroid (2012)
K+ Channels: Function-Structural Overview González C; Baez-Nieto, D; Valencia I.; Oyarzun, I; Rojas P.; Naranjo, D; Latorre R. Article ISI SCOPUS Comprehensive Physiology (2012)
K+ Conduction and Mg2+ Blockade in a Shaker Kv-Channel Single Point Mutant with an Unusually High Conductance Moscoso, C.; Vergara-Jaque, A; Marquez-Miranda, V; Sepúlveda R.V.; Valencia I.; Diaz-Franulic, I; Gonzalez-Nilo, F; Naranjo, D Article ISI SCOPUS Biophysical Journal (2012)
Reduced voltage sensitivity in a K+-channel voltage sensor by electric field remodeling Gonzalez-Perez, V; Stack K.; Boric K; Naranjo, D Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2010)
Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring Opazo, MC; Gianini, A; Pancetti F.; Azkcona, G; Alarcón L.; Lizana, R; Noches, V; Gonzalez PA; Porto M.; Mora S.; Rosenthal, D; Eugenin, E; Naranjo, D; Bueno, SM; Kalergis, AM; Riedel, CA Article ISI SCOPUS ENDOCRINOLOGY (2008)
Mutations of nonconserved residues within the calcium channel alpha(1)-interaction domain inhibit beta-subunit potentiation Gonzalez-Gutierrez G.; Miranda-Laferte E.; Naranjo, D; Hidalgo, P.; Neely A. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2008)
Slow Inactivation in Shaker K Channels Is Delayed by Intracellular Tetraethylammonium Gonzalez-Perez, V; Neely A.; Tapia C.; Gonzalez-Gutierrez G.; Contreras, G.; Orio, P; Lagos, V; Rojas G.; Estevez, T.; Stack K.; Naranjo, D Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2008)
Calcium channel subtypes differentially regulate fusion pore stability and expansion Ardiles AO; Gonzalez-Jamett AM; Maripillán J; Naranjo, D; Caviedes P.; Cárdenas AM Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2007)
Slow inactivation in voltage gated potassium channels is insensitive to the binding of pore occluding peptide toxins Oliva, C; González V.; Naranjo, D Article ISI SCOPUS BIOPHYSICAL JOURNAL (2005)
Inhibition of single Shaker K channels by kappa-Conotoxin-PVIIA Naranjo, D Article ISI BIOPHYSICAL JOURNAL (2002)
Splitting the two pore domains from TOK1 results in two cationic channels with novel functional properties Saldana, C; Naranjo, D; Coria, R; Pena, A; Vaca, L Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A marine snail neurotoxin shares with scorpion toxins a convergent mechanism of blockade on the pore of voltage-gated K channels Garcia, E; Scanlon, M; Naranjo, D Article ISI JOURNAL OF GENERAL PHYSIOLOGY (1999)
Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA Scanlon, MJ; Naranjo, D; Thomas, L; Alewood, PF; Lewis, RJ; Craik, DJ Article ISI STRUCTURE (1997)
A strongly interacting pair of residues on the contact surface of charybdotoxin and a Shaker K+ channel Naranjo, D; Miller, C Article ISI NEURON (1996)
Modal gating in neuronal and skeletal muscle ryanodine-sensitive Ca2+ release channels Armisen, R.; Sierralta, J.; Velez, P.; Naranjo, D.; Suarez-Isla, B. A. Article ISI American Journal of Physiology-Cell Physiology (1996)
2 SUBCELLULAR MECHANISMS UNDERLIE CALCIUM-DEPENDENT FACILITATION OF BIOLUMINESCENCE NARANJO, D; PLANT, C; DUNLAP, K; BREHM, P Article ISI NEURON (1994)
A SIMPLE-MODEL FOR SURFACE-CHARGE ON ION-CHANNEL PROTEINS NARANJO, D; LATORRE, R; CHERBAVAZ, D; MCGILL, P; SCHUMAKER, MF Article ISI BIOPHYSICAL JOURNAL (1994)
ION CONDUCTION IN SUBSTATES OF THE BATRACHOTOXIN-MODIFIED NA+ CHANNEL FROM TOAD SKELETAL-MUSCLE NARANJO, D; LATORRE, R Article ISI BIOPHYSICAL JOURNAL (1993)
MODAL SHIFTS IN ACETYLCHOLINE-RECEPTOR CHANNEL GATING CONFER SUBUNIT-DEPENDENT DESENSITIZATION NARANJO, D; BREHM, P Article ISI SCIENCE (1993)
Surface charge effects on ion conduction in ion channels. Latorre R, Labarca P, Naranjo D. Article ISI ION CHANNELS: CHANNEL PRODUCTION AND OPTICAL METHODS (1992)


Biophysical Characterization of a Predicted Shaker Splice Variant with an Unconventional Initiation Codon Moldenhauer, HJ; Delgado, SE; Navarro, N; Naranjo, D Abstract ISI BIOPHYSICAL JOURNAL (2018)
Testing the Hydration Status of the Shaker-K Channel Voltage Sensor Domain with Sugars Diaz-Franulic, I; Naranjo, D Abstract ISI BIOPHYSICAL JOURNAL (2015)
The Role of the Ion Dehydration Process in Low and High Conductance K Channels Sepulveda, RV; Bravo-Moraga, F; Diaz-Franulic, I; Aguayo, D; Naranjo, D; Latorre R.; Gonzalez-Nilo, FD Abstract ISI BIOPHYSICAL JOURNAL (2015)
Insights into the Ion Permeation Process of High and Low Conductance K-Channels using Non-Equilibrium Molecular Dynamics Gonzalez-Nilo, FD; sepulveda, r; Naranjo, D; Aguayo, D; Araya, I.; Varas I.; Bravo F.; Diaz-Franulic, I; Marquez-Miranda, V Abstract ISI BIOPHYSICAL JOURNAL (2014)
Turning a Small into Large Conductance K-Channel - How Far Can We Go? Diaz-Franulic, I; Navarro, N; Gonzalez-Nilo, F; Sepulveda, RV; Naranjo, D Abstract ISI BIOPHYSICAL JOURNAL (2014)
Tuning the Single Channel Conductance of Shaker K-Channels Diaz-Franulic, I; Herrera, G.; Navarro, N; Naranjo, D Abstract ISI BIOPHYSICAL JOURNAL (2013)
Mg2+ Blockade in a Kv Potassium Channel Mutant having an Unusually High Conductance Naranjo, D; Moscoso, C.; Vergara A.; Marquez, V; sepulveda, r; Valencia I.; Diaz-Franulic, I; Gonzalez-Nilo, F Abstract ISI BIOPHYSICAL JOURNAL (2012)
Charge Reversion to Charge Carrying Positions of S4 in Voltage Gated Shaker K-Channels Gonzalez-Perez, V; Stack K.; Naranjo, D Abstract ISI BIOPHYSICAL JOURNAL (2010)
Ion conduction and tetrapentylammonium sensitivity in a constitutively open shaker K-channels Naranjo, D; Moscoso, C. Abstract ISI BIOPHYSICAL JOURNAL (2007)
Two slow inactivation processes in Shaker-IR potassium channels Naranjo, D; Oliva, C; González V.; Neely A. Abstract ISI BIOPHYSICAL JOURNAL (2005)
Loose coupling between voltage sensing and pore opening in kexp-2 inward rectifying K+ channels. Tapia C.; Naranjo, D; Neely A. Abstract ISI BIOPHYSICAL JOURNAL (2004)
Incorporation of Shaker K+ channels to the plasma membrane of Xenopus oocytes is regulated by Thapsigargin sensitive Ca+2 store. Torres-Salazar, D; Naranjo, D; Neely A. Abstract ISI BIOPHYSICAL JOURNAL (2003)
kappa-Conotoxin-PVIIA is a K-channel pore blocker toxin that does not alter slow inactivation. Naranjo, D Abstract ISI BIOPHYSICAL JOURNAL (2003)
Ca2+ dependent increase of ionic currents due to recruitment of K+ channels into the plasma membrane of Xenopus oocytes Torres-Salazar, D; Neely A.; Naranjo, D Abstract ISI BIOPHYSICAL JOURNAL (2002)


Assembly of Shaker K-Channels from a Random Mixture of Subunits Carrying Different Mutations Naranjo, David; Latorre, Ramon; Sáez, Juan Carlos BookSection (1997)


Peptide toxins as conformational probes for K-channels Naranjo, D ConferencePaper ISI PUMPS, TRANSPORTERS, AND ION CHANNELS: STUDIES ON THEIR STRUCTURE, FUNCTION, AND CELL BIOLOGY (2005)
A marine snail kappa-conotoxin blocks the pore of K+ channels as alpha-KTX scorpion toxins do Naranjo, David; García, Esperanza ConferencePaper (2004)


Integración de la biología estructural al desarrollo de la bionanotecnología PIA (ACT 1107) Proyecto 2013-2016 Investigador(a)
STUDY OF STRUCTURAL AND DYNAMIC PROPERTIES THAT GOVERN SELECTIVITY AND CONDUCTANCE OF K CHANNELS UNDER NON-EQUILIBRIUM CONDITIONS. FONDECYT (1131003) Proyecto 2013-2016 Coinvestigador(a)
TRANSDISCIPLINARY STUDIES BASED ON COMPUTATIONAL BIOLOGY, MOLECULAR BIOLOGY, AND ELECTROPHYSIOLOGY, TO GET INSIGHTS INTO THE STRUCTURE-FUNCTION RELATIONSHIPS CODED INTO THE MOLECULAR ARCHITECTURE OF CX26 HEMICHANNELS AND GAP JUNCTION CHANNELS. FONDECYT (1130652) Proyecto 2013-2016 Coinvestigador(a)
CROSS TALK BETWEEN PERMEATION AND VOLTAGE SENSITIVITY IN VOLTAGE GATED POTASSIUM CHANNELS=> FONDECYT (1120819) Proyecto 2012-2015 Inv. Responsable
Centro Interdisciplinartio de Neurociencia de Valparaiso Inicitiva Cientifica Milenio (P09-022-F) Proyecto 2011-2017 Coinvestigador(a)
IONIC CONDUCTION IN K CHANNELS FONDECYT (1090493) Proyecto 2009-2012 Inv. Responsable
Consolidación del programa de Doctorado en Ciencias, mención Neurociencia MECESUP (UVA 0603) Proyecto 2007-2008 Director(a)
Red de estudios de proteínas formadoras de canales de iones. PIA (RED 24) Proyecto 2007-2009 Coinvestigador(a)
Superficies de interacción en el plegamiento y oligomerización de proteínas formadoras de canales iónicos PIA (act #46) Proyecto 2005-2007 Coinvestigador(a)
ESTUDIO DE LOS EFECTOS DE LA INGESTA DEFICIENTE EN I DURANTE LA GESTACION Y LACTANCIA SOBRE=> I) LA NEUROTRANSMISION EXCITADORA Y LA EXPRESION DE NEUROTROFINAS EN LA CORTEZA CEREBRAL E HIPOCAMPO. II) LA EXPRESION DEL TRA FONDECYT (1040349) Proyecto 2004-2007 Coinvestigador(a)
TOXINAS PEPTIDICAS COMO SONDAS CONFORMACIONALES DE CANALES IONICOS ACTIVADOS POR VOLTAJE. FONDECYT (1030285) Proyecto 2003-2007 Inv. Responsable
MECANISMOS MOLECULARES DE LA EXPRESION Y FUNCION DEL CANAL DE CALCIO POR LA SUBUNIDAD ACCESORIA BETA FONDECYT (1020899) Proyecto 2002-2006 Coinvestigador(a)


Pore size matters for potassium channel conductance Naranjo, D; Moldenhauer, H; Pincuntureo, M; Diaz-Franulic, I Review ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2016)

David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

Ignacio Diaz

Profesor asistente

Centro e Bioinformatica y Biologia Integrativa

Universidad Andrés Bello

Santiago, Chile

katherine Stack

Daniel Aguayo

Associate Professor

ITISB

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

Alan Neely

Pofesor

Instituto de Neurociencias

Universidad de Valparaíso

Valparaiso, Estados Unidos

Nieves Navarro

Lab Manager

Biología Molecular

Centro interdisciplinario de neurociencia de Valparaíso

Valparaíso, Chile

VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

christian tapia

ACADEMICO

QUIMICA Y FARMACIA

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Romina Sepúlveda

Profesor Investigador

Facultad de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

Carolina Oliva

Investigador Asociado

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

Ariela Vergara

Assistant Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

GUSTAVO CONTRERAS

Centro Interdisciplinario de Neurociencias de Valparaíso

Valparaiso, Chile

Maria Opazo

Profesor Asociado

Universidad de Las Américas

Santiago, Chile

Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Hans Moldenhauer

Post doc

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA DE VALPARAISO

Esteban Aliaga

Profesor

Kinesiología

Universidad Católica el Maule

Talca, Chile

Floria Pancetti

Director de Departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

Patricio Orio

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

David Naranjo Donoso

Líneas de Investigación

Educación

Ciencias, UNIVERSIDAD DE CHILE. Chile, 1991

Biologia, UNIVERSIDAD DE CHILE. Chile, 1985

Experiencia Académica

Profesor Titular Full Time

Investigador Titular Full Time

Experiencia Profesional

Post Doctoral researcher Full Time

Post Doctoral researcher Full Time

Formación de Capital Humano

Article (25)

Abstract (14)

BookSection (1)

ConferencePaper (2)

Proyecto (12)

Integración de la biología estructural al desarrollo de la bionanotecnología

STUDY OF STRUCTURAL AND DYNAMIC PROPERTIES THAT GOVERN SELECTIVITY AND CONDUCTANCE OF K CHANNELS UNDER NON-EQUILIBRIUM CONDITIONS.

TRANSDISCIPLINARY STUDIES BASED ON COMPUTATIONAL BIOLOGY, MOLECULAR BIOLOGY, AND ELECTROPHYSIOLOGY, TO GET INSIGHTS INTO THE STRUCTURE-FUNCTION RELATIONSHIPS CODED INTO THE MOLECULAR ARCHITECTURE OF CX26 HEMICHANNELS AND GAP JUNCTION CHANNELS.

CROSS TALK BETWEEN PERMEATION AND VOLTAGE SENSITIVITY IN VOLTAGE GATED POTASSIUM CHANNELS=>

Centro Interdisciplinartio de Neurociencia de Valparaiso

IONIC CONDUCTION IN K CHANNELS

Consolidación del programa de Doctorado en Ciencias, mención Neurociencia

Red de estudios de proteínas formadoras de canales de iones.

Superficies de interacción en el plegamiento y oligomerización de proteínas formadoras de canales iónicos

ESTUDIO DE LOS EFECTOS DE LA INGESTA DEFICIENTE EN I DURANTE LA GESTACION Y LACTANCIA SOBRE=> I) LA NEUROTRANSMISION EXCITADORA Y LA EXPRESION DE NEUROTROFINAS EN LA CORTEZA CEREBRAL E HIPOCAMPO. II) LA EXPRESION DEL TRA

TOXINAS PEPTIDICAS COMO SONDAS CONFORMACIONALES DE CANALES IONICOS ACTIVADOS POR VOLTAJE.

MECANISMOS MOLECULARES DE LA EXPRESION Y FUNCION DEL CANAL DE CALCIO POR LA SUBUNIDAD ACCESORIA BETA

Review (1)