Man

David Naranjo Donoso

Profesor titular

Universidad de Valparaíso

VALPARAISO, Chile

Líneas de Investigación


Estructura y Funcion de los canales de iones; Reconstitucion de canales de iones; Proteinas de Membrana; Bioquimica Computacional Simulacion Molecular; Nanobiotecnologia

Educación

  •  Ciencias, UNIVERSIDAD DE CHILE. Chile, 1991
  •  Biologia, UNIVERSIDAD DE CHILE. Chile, 1985

Experiencia Académica

  •   Profesor Titular Full Time

    UNIVERSIDAD DE VALPARAISO

    Ciencias

    Valparaiso, Chile

    2002 - A la fecha

  •   Investigador Titular Full Time

    Universidad Nacional Autónoma de Mexico

    Instituto de Fisiología Celular

    DF, México

    1997 - 2002

Experiencia Profesional

  •   Post Doctoral researcher Full Time

    State university of New York

    Stony Brook, Estados Unidos

    1991 - 1993

  •   Post Doctoral researcher Full Time

    Brandeis University

    Boston, Estados Unidos

    1993 - 1997

Formación de Capital Humano


4 tesis de pregrado (1 en calidad de co-tutor)
4 tesis de magister/maestria (3 en calidad de co-tutor)
4 tesis de Doctorado (1 en calidad de co-tutor)
4 guia postdoctoral



 

Article (25)

Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states
Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K+ channels
Effective pore size and radius of capture for K+ ions in K-channels
Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels
Zebrafish Ca(V)2.1 Calcium Channels Are Tailored for Fast Synchronous Neuromuscular Transmission
Hypothyroidism in the Adult Rat Causes Incremental Changes in Brain-Derived Neurotrophic Factor, Neuronal and Astrocyte Apoptosis, Gliosis, and Deterioration of Postsynaptic Density
K+ Channels: Function-Structural Overview
K+ Conduction and Mg2+ Blockade in a Shaker Kv-Channel Single Point Mutant with an Unusually High Conductance
Reduced voltage sensitivity in a K+-channel voltage sensor by electric field remodeling
Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring
Mutations of nonconserved residues within the calcium channel alpha(1)-interaction domain inhibit beta-subunit potentiation
Slow Inactivation in Shaker K Channels Is Delayed by Intracellular Tetraethylammonium
Calcium channel subtypes differentially regulate fusion pore stability and expansion
Slow inactivation in voltage gated potassium channels is insensitive to the binding of pore occluding peptide toxins
Inhibition of single Shaker K channels by kappa-Conotoxin-PVIIA
Splitting the two pore domains from TOK1 results in two cationic channels with novel functional properties
A marine snail neurotoxin shares with scorpion toxins a convergent mechanism of blockade on the pore of voltage-gated K channels
Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA
A strongly interacting pair of residues on the contact surface of charybdotoxin and a Shaker K+ channel
Modal gating in neuronal and skeletal muscle ryanodine-sensitive Ca2+ release channels
2 SUBCELLULAR MECHANISMS UNDERLIE CALCIUM-DEPENDENT FACILITATION OF BIOLUMINESCENCE
A SIMPLE-MODEL FOR SURFACE-CHARGE ON ION-CHANNEL PROTEINS
ION CONDUCTION IN SUBSTATES OF THE BATRACHOTOXIN-MODIFIED NA+ CHANNEL FROM TOAD SKELETAL-MUSCLE
MODAL SHIFTS IN ACETYLCHOLINE-RECEPTOR CHANNEL GATING CONFER SUBUNIT-DEPENDENT DESENSITIZATION
Surface charge effects on ion conduction in ion channels.

Abstract (14)

Biophysical Characterization of a Predicted Shaker Splice Variant with an Unconventional Initiation Codon
Testing the Hydration Status of the Shaker-K Channel Voltage Sensor Domain with Sugars
The Role of the Ion Dehydration Process in Low and High Conductance K Channels
Insights into the Ion Permeation Process of High and Low Conductance K-Channels using Non-Equilibrium Molecular Dynamics
Turning a Small into Large Conductance K-Channel - How Far Can We Go?
Tuning the Single Channel Conductance of Shaker K-Channels
Mg2+ Blockade in a Kv Potassium Channel Mutant having an Unusually High Conductance
Charge Reversion to Charge Carrying Positions of S4 in Voltage Gated Shaker K-Channels
Ion conduction and tetrapentylammonium sensitivity in a constitutively open shaker K-channels
Two slow inactivation processes in Shaker-IR potassium channels
Loose coupling between voltage sensing and pore opening in kexp-2 inward rectifying K+ channels.
Incorporation of Shaker K+ channels to the plasma membrane of Xenopus oocytes is regulated by Thapsigargin sensitive Ca+2 store.
kappa-Conotoxin-PVIIA is a K-channel pore blocker toxin that does not alter slow inactivation.
Ca2+ dependent increase of ionic currents due to recruitment of K+ channels into the plasma membrane of Xenopus oocytes

BookSection (1)

Assembly of Shaker K-Channels from a Random Mixture of Subunits Carrying Different Mutations

ConferencePaper (2)

Peptide toxins as conformational probes for K-channels
A marine snail kappa-conotoxin blocks the pore of K+ channels as alpha-KTX scorpion toxins do

Proyecto (12)

Integración de la biología estructural al desarrollo de la bionanotecnología
STUDY OF STRUCTURAL AND DYNAMIC PROPERTIES THAT GOVERN SELECTIVITY AND CONDUCTANCE OF K CHANNELS UNDER NON-EQUILIBRIUM CONDITIONS.
TRANSDISCIPLINARY STUDIES BASED ON COMPUTATIONAL BIOLOGY, MOLECULAR BIOLOGY, AND ELECTROPHYSIOLOGY, TO GET INSIGHTS INTO THE STRUCTURE-FUNCTION RELATIONSHIPS CODED INTO THE MOLECULAR ARCHITECTURE OF CX26 HEMICHANNELS AND GAP JUNCTION CHANNELS.
CROSS TALK BETWEEN PERMEATION AND VOLTAGE SENSITIVITY IN VOLTAGE GATED POTASSIUM CHANNELS=>
Centro Interdisciplinartio de Neurociencia de Valparaiso
IONIC CONDUCTION IN K CHANNELS
Consolidación del programa de Doctorado en Ciencias, mención Neurociencia
Red de estudios de proteínas formadoras de canales de iones.
Superficies de interacción en el plegamiento y oligomerización de proteínas formadoras de canales iónicos
ESTUDIO DE LOS EFECTOS DE LA INGESTA DEFICIENTE EN I DURANTE LA GESTACION Y LACTANCIA SOBRE=> I) LA NEUROTRANSMISION EXCITADORA Y LA EXPRESION DE NEUROTROFINAS EN LA CORTEZA CEREBRAL E HIPOCAMPO. II) LA EXPRESION DEL TRA
TOXINAS PEPTIDICAS COMO SONDAS CONFORMACIONALES DE CANALES IONICOS ACTIVADOS POR VOLTAJE.
MECANISMOS MOLECULARES DE LA EXPRESION Y FUNCION DEL CANAL DE CALCIO POR LA SUBUNIDAD ACCESORIA BETA

Review (1)

Pore size matters for potassium channel conductance
46
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

7
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

2
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

2
Alan Neely

Pofesor

Instituto de Neurociencias

Universidad de Valparaíso

Valparaiso, Estados Unidos

2
VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

2
christian tapia

ACADEMICO

QUIMICA Y FARMACIA

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

2
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

2
Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Daniel Aguayo

Assistant Professor

Molecular Biophysics & Bioinformatics Group

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Carolina Oliva

Investigador Asociado

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
Ariela Vergara

Assistant Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

1
GUSTAVO CONTRERAS

Centro Interdisciplinario de Neurociencias de Valparaíso

Valparaiso, Chile

1
Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Maria Opazo

Profesor honorarios

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Hans Moldenhauer

Post doc

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA DE VALPARAISO

1
Floria Pancetti

Director de Departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Patricio Orio

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

1
Esteban Aliaga

Profesor

Kinesiología

Universidad Católica el Maule

Talca, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile