Foto_pablo_lab.jpg_thumb90

Pablo Andrés Caviedes Fernández

Full professor

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

Líneas de Investigación


CERAMIC NANOMATERIALS; HYBRID NANOCOMPOSITE BIOMATERIALS; mecanisms of neurodegeneration ; Down syndrome, cell therapy, stem cell differentiation, tissue microencapsulation; Modification of Natural Polymers Biomimetic; Bio-related Materials;

Educación

  •  Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 1986
  •  Biomedical Sciences, UNIVERSIDAD DE CHILE. Chile, 1998

Experiencia Académica

  •   Visiting Fellow Full Time

    NATIONAL INSTITUTE OF HEALTH

    Natl. Institute on Aging

    Bethesda, MD, Estados Unidos

    1986 - 1989

  •   Visiting Associate Full Time

    national institutes of health

    National Institue on Diabetes, Digestive and Kidney Diseases

    Bethesda, MD, Estados Unidos

    1989 - 1991

  •   Investigador Asociado Full Time

    Centro de Estudios CIentificos de Santiago

    Santiago, Chile

    1991 - 1992

  •   Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    1992 - A la fecha

  •   Senior researcher Part Time

    Sansum Diabetes Research Institute

    Santa Barbara, CA, Estados Unidos

    2000 - 2003

  •   Profesor Titular Part Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias Física y Matemáticas

    Santiago, Chile

    2020 - A la fecha

  •   Profesor Titular Part Time

    Tip: Search for English results only. You can specify your search language in Preferences Instituto Milenio de Dinámica Celular y BiotecnologíaTip: Search for English results only. You can specify your search language in Preferences Instituto Milenio de

    Ssantiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Visiting Fellow Full Time

    National Institutes of Heath

    Bethesda, MD, Estados Unidos

    1986 - 1989

  •   Visiting Associate Full Time

    National Institutes of Heath

    Bethesda, MD, Chile

    1989 - 1991

  •   Associate researcher Full Time

    Centro de Estudios Cientificos de Santiago

    Snatiago, Chile

    1991 - 1992

  •   Senior Researcher Part Time

    Sansum Diabetes Research Institute

    Santa Barbara, CA, Estados Unidos

    2000 - 2003

  •   Professor Full Time

    University of Chile

    Santiago, Chile

    1992 - A la fecha

  •   Profesor Titular Part Time

    Instituto Milenio de Dinámica Celular y Biotecnología (ICDB)

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


Thesis directed (2007 – present. 15 prior to 2007)

1.- Ongoing:

- Christian Arriagada. PhD Thesis, PhD program in Biomedical Sciences, Fac. of Medicine, Univ. of Chile. Autophagy in neuronal cell lines established from a mouse model of Down syndrome
- Claudia Jara Cancino. Thesis Director, PhD in Pharmacology, Faculty of Chemistry & Pharmacy, Univ. of Chile. Microencapsulation of spherical cell aggregates of ? and ? cells, differentiated from human adipose tissue derived mesenchymal stem cells.
- Natalia Barraza Thesis Director, PhD in Pharmacology, Faculty of Chemistry & Pharmacy, Univ. of Chile.. Eff of overexpressed APP on PAK activity sand actin filament ploymerization in a celular model of Down symdrome
- Belén Gaete, Thesis Director, Bs degree in Biochemstry, Pontificial Catholic Univ. of Valparaíso, Chile.. Phamacological modulation of P21- Activated kinases (PAK) in an in vitro neuronal model of Down syndrome: Consequnces on process growth and branching.

2.- Finished
- Ramón Pérez Nuñez. Thesis Director, Thesis Director, PhD in Biochemistry, Faculty of Chemistry & Pharmacy, Univ. of Chile.. Effect of DSCAM overexpression on morphological parameters in cell models of Down síndrome: the role of the P21- Activated kinases (PAK) pathway. Possible examination date: August 2016
Esteban González. PhD Thesis, PhD program in Medical Sciences, Fac. of Medicine, Univ. of Chile. Differentiation of human stem and mesenchimal cells into myocardiocytes: Application to cell transplant in ischemic heart disease. Exam: June 15, 2016
- Paulina Salazar. Thesis Director, MsC in Genetics, Faculty of Medicine, Univ . de Chile. Study of nFATC4 activity in a neuronal cell line derived from a murine model of Down syndrome Exam: June 27, 2015.
- Nicolás Pereira. Thesis Director, MsC in Molec & Cellular Biomedicine, Faculty of Medicine, Univ . de Chile. Effects od differnt cryopreservation media on adipose-derived stem cell viability: Which is the best cryporeservative? Exam: June 30, 2015.
- Ximena Cataldo Thesis Director, MsC in Nutrition, Faculty of Medicine, Univ . de Chile. Neuroprotection induce by ?-cryptoxanthine in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse, and animal model for Down syndrome. Exam: November 3 2014
- Natalia Galarce Toro. Bs degree in Chemical Engineering, Univ.of Chile. Effect of ion release on cell viability in polymeric composites bearing copper nanoparticles. Exam: Dicembe 2013.
- Macarena Beltrán Carpentier. Bs degree in Chemical Engineering, Univ.of Chile. Study on the biocompatibility of plymeric composites bearing coppr nanoparticles. Exam: June 2013.
- Natalia Barraza: Contribution of DSCR1 to tau protein hyperphosphorilation in trisomy 21. MsC in Biological Sci, major in Neuroscience. U. Valparaíso (Co tutor, A.M. Cárdenas). Exam: July 2013
Mario Acuña. Msc Thesis codirector (with C. Arriagada). Effect of RCAN1 overexpression on Ca2+ currents in a cell line derived from the cerebral cortex of a trisomy 16 mouse; an animal un model of Down Syndrome. Fac. Of Sciences. U. of Chile. Exam: January 2012.
- Jura Mikkola. Thesis director, MSc in Neuroscience. University of Jyväskylä, Finland. Effect of Sod1 and Sod1/APP knockdown in cholinergic dysfunction in a neuronal cell line derved from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome. Exam: July 2008.
- Adriana Armijo. Thesis director, MSc in Neuroscience, Faculty of Medicine, Univ. of Chile. Characterization of a cell line derived from the primary motor cortex off an adult rat: A model for cell transplant therapy in rats submitted to cerebral ischemia. Exam: March 2008
- Patricio Cabané Toledo. Thesis director, PhD in Medical Sciences, Faculty of Medicine, Univ. of Chile. Optimization of culture conditions for parathyroid cells: Use in cell transplant therapy in hypoparathyroidism. Exam: January 2008
- Ignacio Díaz Franulic. Thesis director, Degree in Biochemistry, University of Chile. Effect of Slc5a3 (SMIT1, myo-inositol cotransporter) knockdown in cholinergic dysfunction of a cell line derived from the brain of a trisomy 16 mouse, an animal model of Down syndrome. Exam: December, 2007.
- Paola Fernández Olivares. Thesis codirector (with A.M. Cárdenas), Degree in Biochemistry, Catholic University of Valparaiso. Effect of Slc5a3 (SMIT1, myo-inositol cotransporter) knockdown in Ca2+ signaling in a cell line derived from the brain of a trisomy 16 mouse, an animal model of Down syndrome. Exam: June 29, 2007.

Tutorships, Research Units: Rodrigo Carrasco (PhD Program in Medical Sciences, Fac. of Medicine,, Univ. of Chile , 2007). Rodrigo Nieto (PhD Program in Medical Sciences, Fac. of Medicine,, Univ. of Chile , 2007). Dario Vázquez (PhD Program in Medical Sciences, Fac. of Medicine,, Univ. of Chile , 2007). Jorge Noriega(PhD Program in Biomedical Sciences, Fac. of Medicine,, Univ. of Chile , 2009). Mario Acuña (MsC Program, Faculty of Science, Univ. de Chile., 2010)

Teaching, graduate courses:
-Professor, Graduate course, Introduction to Neuroscience, Fac. of Medicine, Univ. de Chile. 2007- present.
-Professor, Graduate course, Systems physiology. Fac. of Medicine, Univ. de Chile. 2007- present.
-Professor, Graduate course,, Physical activity Physiology. Fac. of Medicine, Univ. de Chile. 2007- 2009.
-Professor & coordinator, Internacional course: “Molecular & Cellular Mechanisms of Neuronal Damage. Therapeutical approaches”. March 23 - 25, 2007 (Pucón, Chile), and April 23 -26 de Abril, 2009 (Arica, Chile)
- Professor, MsC program Biological Sciences, Univ. of Valparaíso (2007). Topic:: “Cellular and trophic factor therapy in neurodegenerative pathology”
Bibliographic seminars, mechanisms of neurodegenerative pathology (Coord. Claudio Hetz) (2009 – 2010)

Member PhD in Pharmacology , Committee, Faculty of medicine and Faculty of Chemistry & Pharmacy, Fac of Medicine, Univ of Chile. Since January 2014.


Difusión y Transferencia


PAPERS PRIOR TO 1995:

- Fiedler, J., Rapoport, S.I., Epstein, C.J., Caviedes, R. and Caviedes, P. Altered cholinergic function in cultured neurons from the trisomy 16 mouse fetus, a model for Down Syndrome. Brain Res., 658 (1994), 27-32.

- Caviedes, P., Caviedes, R., Liberona, J.L. and Jaimovich, E. Ion currents in a skeletal muscle cell line from a Duchenne muscular dystrophy patient. Muscle & Nerve. 17 (1994), 1021-1028.

- Vargas, F. F., Caviedes, P. and Grant, D. S.. Electrophysiological characteristics of cultured human umbilical vein endothelial cells. Microvasc. Res. 47 (1994), 153-165.

- Caviedes, P., Olivares, E., Salas, K., Caviedes, R. and Jaimovich, E.. Calcium fluxes, ion currents and dihydropyridine receptors in a newly established cell line from rat heart muscle. J. Molec. & Cell Cardiol. (1993), 25 (1993), 829-845.

- Caviedes, P., Koistinaho, J., Ault, B. and Rapoport, S. I.. Effects of nerve growth factor on the electrical membrane properties of cultured dorsal root ganglia neurons from normal and trisomy 21 human fetuses. Brain Res., 556 (1991), 285-291.

- Caviedes, P., Ault, B. and Rapoport, S. I.. A replated culture preparation improves whole cell voltage clamp conditions of human fetal sensory neurons. J. Neurosci. Meth., 35 (1990), 57-61.

- Caviedes, P., Ault, B. and Rapoport, S. I.. Electrical membrane properties of cultured dorsal root ganglion neurons from trisomy 19 mouse fetuses: a comparison with the trisomy 16 mouse fetus, a model for Down syndrome. Brain Res., 511 (1990) 169-172.

- Caviedes, P., Ault, B. and Rapoport, S. I.. The role of altered sodium currents in the action potential abnormalities of cultured dorsal root ganglion neurons from trisomy 21 (Down syndrome) human fetuses. Brain Res., 510 (1990) 229-236.

- Ault, B., Caviedes, P., Hidalgo, J., Epstein, C.J. and Rapoport, S. I.. Electrophysiological analysis of cultured fetal mouse dorsal root ganglion neurons transgenic for human superoxide dismutase-1, a gene in the obligate Down syndrome region of chromosome 21. Brain Res., 497 (1989) 191-194.

- Ault, B., Caviedes, P. and Rapoport, S. I.. Neurophysiological abnormalities in cultured dorsal root ganglion neurons from the trisomy 16 mouse fetus, a model for Down Syndrome. Brain Res., 485 (1989) 165-170.

PATENTS

1.- Freeman, TB, Caviedes, P., Caviedes, R. Conditioned medium and Proliferated Cell Lines Produced Therefrom. Pub US 2008/0175828 A1, Date: Dec 25, 2012. US Patent No US 8.337.829 B2..

2.- Freeman, TB, Caviedes, P., Caviedes, R. Proliferated Cell Lines and Uses Thereof. Japanese patent number 4.741.189. Filed Feb 7, 2003. Granting date: May 13, 2011.

3.- Caviedes, P., Caviedes, R., Freeman, TB, Asenjo, J., Andrews, B., Sepúlveda, D, Arriagada, C. y Salazar Rivera, J.. Materials and Methods for Regulating Process Formation in Cell Culture. US Patent, Letters, US 7.323.333 B2, Date: Jan 29, 2008. Pub. US Patent No 8,252,279, 8 Agosto 2012.

4.- Caviedes, P., Caviedes, R., Freeman TB, Sanberg, PR., Cameron DF. Proliferated Cell Lines and Uses Thereof. Canada Application No 2.476.214. Filed 2/7/2003, number pending.

5.- Cameron, DF, Caviedes, P., Caviedes R., Freeman, TB, Sanberg, PR. Proliferated cell Lines and uses thereof. Europe application EP 157524 (A2). Pub Date Sept 21, 2005. Number pending.


Premios y Distinciones

  •   Conicyt PhD Fellowship

    conicyt

    Chile, 1991

    National Fellowship to carry out a PhD program


 

Article (88)

Defects in actin dynamics in myoblasts derived from dysferlinopathy patients are restored by dysferlin C2-domains
Defects in g-actin incorporation into filaments in myoblasts derived from dysferlinopathy patients are restored by dysferlin C2 domains
Effects of a Tripeptide on Mitogen-Activated Protein Kinase and Glycogen Synthase Kinase Activation in a Cell Line Derived from the Fetal Hippocampus of a Trisomy 16 Mouse, an Animal Model of Down Syndrome
Effects of a Tripeptide on Mitogen-Activated Protein Kinase and Glycogen Synthase Kinase Activation in a Cell Line Derived from the Foetal Hippocampus of a Trisomy 16 Mouse: an Animal Model of Down Syndrome
Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue
Myofibers deficient in connexins 43 and 45 expression protect mice from skeletal muscle and systemic dysfunction promoted by a dysferlin mutation
N-Acetylcysteine Reduces Skeletal Muscles Oxidative Stress and Improves Grip Strength in Dysferlin-Deficient Bla/J Mice
N-acetylcysteine Reduces Skeletal Muscles Oxidative Stress and Improves Grip Strength in Dysferlin-Deficient Bla/J Mice.
Comparative study of the neural differentiation capacity of mesenchymal stromal cells from different tissue sources=> An approach for their use in neural regeneration therapies.
Paving the Way for Therapy=> The Second International Conference of the Trisomy 21 Research Society.
Poly(lactic acid) composites based on graphene oxide particles with antibacterial behavior enhanced by electrical stimulus and biocompatibility
RCAN1 Knockdown Reverts Defects in the Number of Calcium-Induced Exocytotic Events in a Cellular Model of Down Syndrome
Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells
Effect of copper nanoparticles on the cell viability of polymer composites
Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome)
Microencapsulation of parathyroid cells for the treatment of Hypoparathyroidismell viability of polymer composites
Broadening the imaging phenotype of dysferlinopathy at different disease stages
Cryopreservation of adipose derived stromal cells: comparison of different cryopreservation media
Cryopreservation of adipose derived stromal cells: Comparison of different cryopreservation media [Criopreservación de células estromales derivadas del tejido adiposo: Comparación de diferentes medios de criopreservación]
Dysferlin function in skeletal muscle: possible pathological mechanisms and therapeutical targets in dysferlinopathies
Osseointegration properties of titanium dental implants modified with a nanostructured coating based on ordered porous silica and bioactive glass nanoparticles
Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension
Proteome Profiling and Ultrastructural Characterization of the Human RCMH Cell Line: Myoblastic Properties and Suitability for Myopathological Studies
The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes
Extracellular alpha-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane
Sol-gel synthesis and in vitro bioactivity of copper and zinc-doped silicate bioactive glasses and glass-ceramics
The Effect of the Nanoscale Structure of Nanobioceramics on Their In Vitro Bioactivity and Cell Differentiation Properties
Utility of magnetic resonance imaging in the diagnosis of hereditary muscular diseases
CORTICOSTERONE AFFECTS THE DIFFERENTIATION OF A NEURONAL CEREBRAL CORTEX-DERIVED CELL LINE THROUGH MODULATION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR
Dynamin-2 in nervous system disorders
Dynamin-2 in nervous system disorders.
Characterization of human parathyroid cell line (RCPTH) and tumorigenicity evaluation in NOD/SCID
Detección de Parafibromina en Patología de Paratiroides
Detección inmunohistoquímica de parafibromina en patología de paratiroides
Dynamin-2 function and dysfunction along the secretory pathway
Immunohistochemical detection of parafibromin in parathyroid pathology
Altered Voltage Dependent Calcium Currents in a Neuronal Cell Line Derived From the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Down Syndrome
Electrical Stimulation Induces Calcium-dependent Up-regulation of Neuregulin-1 beta in Dystrophic Skeletal Muscle Cell Lines
Electrical stimulation induces calcium-dependent up-regulation of neuregulin-1? in dystrophic skeletal muscle cell lines
Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson's Disease
Role of protein tau in neuronal damage in Alzheimer’s disease and Down syndrome
Autophagy Protects Against Aminochrome-Induced Cell Death in Substantia Nigra-Derived Cell Line
In vitro antiproliferative activity of 3 H-spiro [1-benzofuran-2,1 '-cyclohexane] derivatives
In vitro antiproliferative activity of 3 H-spiro [1-benzofuran-2,1'-cyclohexane] derivatives Actividad antiproliferativa in vitro de derivados de 3 H-spiro [1-benzofuran-2,1'-cyclohexano]
Microencapsulación de células y tejido para terapia celular
Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line
Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome
Erratum to: Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line
Isolation of Viable Porcine Islets by Selective Osmotic Shock Without Enzymatic Digestion
Allotransplant of Microencapsulated Parathyroid Tissue in Severe Postsurgical Hypoparathyroidism: A Case Report
Copper center dot Dopamine Complex Induces Mitochondrial Autophagy Preceding Caspase-independent Apoptotic Cell Death
Copper·dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death
Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse
Mechanism of copper-induced cell death
Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line
The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolism
Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson's disease
Calcium channel subtypes differentially regulate fusion pore stability and expansion
Endosomal abnormalities related to amyloid precursor protein in cholesterol treated cerebral cortex neuronal cells derived from trisomy 16 mice, an animal model of Down syndrome
Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell Line - An experimental cell model for dopamine toxicity studies
Optimización de cultivos de hepatocitos humanos para estudios de citotoxicidad
Altered calcium currents in cultured sensory neurons of normal and trisomy 16 mouse fetuses, an animal model for human trisomy 21 (Down Syndrome)
Establecimiento de la primera línea celular de paratiroides humana
Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of Down syndrome
Neuronal dysfunction in Down syndrome: Contribution of neuronal models in cell culture
Cell lines as in vitro models for drug screening and toxicity studies
Dopamine-dependent iron toxicity in cells derived from rat hypothalamus
Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra
On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation
Corticosterone down-regulates dopamine D-4 receptor in a mouse cerebral cortex neuronal cell line
Corticosterone down-regulates dopamine D4 receptor in a mouse cerebral cortex neuronal cell line
Cultivo primario e inmortalización de células de paratiroides para trasplante celular, en hipoparatiroidismo quirúrgico
MPP(+)-induced degeneration is potentiated by dicoumarol in cultures of the RCSN-3 dopaminergic cell line. Implications of neuromelanin in oxidative metabolism of dopamine neurotoxicity
Zopiclone, but not brotizolam, impairs memory storage during sleep
A dorsal root ganglia cell line derived from trisomy 16 fetal mice, a model for Down syndrome
Cell lines derived from hippocampal neurons of the normal and trisomy 16 mouse fetus (a model for Down syndrome) exhibit neuronal markers, cholinergic function, and functional neurotransmitter receptors
DT-DIAPHORASE: A NEUROPROTECTIVE ENZYME OF DOPAMINERGIC SYSTEMS
Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome
Neurotoxicity of MAO inhibitors in adult rat hypothalamic cell culture
NEUROTOXICITY OF SOME MAO INHIBITORS IN ADULT RAT HYPOTHALAMIC CELL CULTURE
Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line
COPPER NEUROTOXICITY IS DEPENDENT ON DOPAMINE-MEDIATED COPPER UPTAKE AND ONE-ELECTRON REDUCTION OF AMINOCHROME IN RAT SUBSTANTIA NIGRA NEURONAL CELL LINE
Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival
Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome
Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice
Studies of aminochrome toxicity in a mouse derived neuronal cell line: is this toxicity mediated via glutamate transmission?
Calcium signals in cell lines derived from the cerebral cortex of normal and trisomy 16 mice
Expression of ion channels during differentiation of a human skeletal muscle cell line

Abstract (8)

Prenatal restrain stress affects the expression of neuronal nicotinic acetylcholine receptors in the brain of adult rat offspring
Exendin-4 in addition to tacrolimus improves viability in cultured beta cells
Islets purified by differential osmotic shock maintain normal distribution of cellular subpopulations and electrical coupling
Monoamine transporter inhibitors and norepinephrine inhibit dopamine-dependent iron neurotoxicity
On the mechanism of dopamine-dependent copper toxicity
Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 18 mice. An animal model of human Down's syndrome
Morphological characterization and intracellular calcium signals in cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of human Down's syndrome
The possible role of one-electron reduction of aminochrome in the neurodegeneration of the dopaminergic systems and the neuroprotective role of DT-diaphorase

BookSection (3)

RCSN Cell System for Identifying Dopaminergic Neurotoxicity
In vitro Models for the Study of Cell Function and Transplant Therapy.
The Cell in Culture. In vitro Models for the Study of Cell Function and Transplant Therapy

BookWhole (1)

Microencapsulation of Parathyroid Cells for the Treatment of Hypoparathyroidism

ConferencePaper (3)

Formation of cellular aggregatews composed of differentiated insulin and glucagon producing cells from human mesenchymal cells derived from adipose tissue (HASC)
The UCHT1 method has a proliferative effect in human adipose stem cells (HASC)
An immortalized neuronal cell line derived from the substantia nigra of an adult rat: Application to cell transplant therapy

EditorialMaterial (1)

Cellular and tissue microencapsulation for cellular therapy

Errata (3)

Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson's Disease (vol 22, pg 177, 2012)
Erratum to: Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line (Neurotoxicity Research DOI: 10.1007/s12640-009-9148-4)
Cell lines as in vitro models for drug screening and toxicity studies (vol 31, pg 757, 2005)

NewsItem (1)

The price of development in chile: Overcoming environmental hazards produced by heavy industrial exploitation

Patent (2)

Methods for cell therapy
Materials and Methods for Regulating Process Formation in Cell Culture

Proyecto (42)

Ketogenic diet ameliorates dysferlinopathy phenotype by promoting mitochondrial function in in vitro and in vivo models of the disease.
Adquisición de un sistema de biorreactor para el escalamiento de la producción de biomasa y compuestos de interés biotecnológico a partir de células animales en cultivo
Escalamiento en la producción de células mesenquimales derivadas de tejido humano adiposo para su diferenciación a células productoras de Insulina y glucagon
Role of dysferlin in cytoskeletal actin remodeling and its impact on vesicle trafficking and membrane repair in muscular dystrophy linked to dysferlin mutations
ROLE OF DYSFERLIN IN CYTOSKELETAL ACTIN REMODELING AND ITS IMPACT ON VESICLE TRAFFICKING AND MEMBRANE REPAIR IN MUSCULAR DYSTROPHY LINKED TO DYSFERLIN MUTATIONS.
Further insights on the study of limb girdle muscular dystrophies (LGMD) in the Chilean population: Linking genetic mutation, epidemiology, and cellular mechanisms of the disease
FURTHER INSIGHTS ON THE STUDY OF LIMB GIRDLE MUSCULAR DYSTROPHIES (LGMD) IN THE CHILEAN POPULATION=> LINKING GENETIC MUTATION, EPIDEMIOLOGY, AND CELLULAR MECHANISMS OF THE DISEASE.
Equipo de prototipado rapido para producción de scaffolds mediante diseño asistido por computadora: 3D bioplotter
Adquisición de un microscopio electrónico de barrido y equipos auxiliares (sem-edx) para investigación avanzada en ciencias odontológicas
La actividad física acelera la progresión del daño muscular en modelos animales de disferlinopatías: Posible papel de los hemicanales.
Role of overexpressed DSCAM and APP in PAK kinase derregulation, and the consequent neuronal dysfunction in invitro models of Down syndrome=> A quest for cellular therapeutical targets.
Synthesis and evaluation of bioactive nanocomposites based on ceramic nanoparticles and polymers for bone tissue engineering in dentistry
Molecular and cellular mechanisms of muscular dystrophy related to en mutations of dysferlin
Molecular and cellular mechanisms of muscular dystrophy related to mutations of dysferlin
Studies on degeneration mechanism of dopaminergic neurons induced by aminochrome and polymorphism prevalence in Chilean Parkinson's patients.
Role of Dyrk1a and Dscr1 overexpression in genetic regulatory circuits and cellular dysfunction of immortalized neuronal cells derived from the trisomy 16 mouse, an animal model of human Down syndrome=> Possible therapeutic targets.
Non-enzymatic isolation of viable islets by differential osmotic shock.
Vectores adenovirales para la terapia génica en el tratamiento del alcoholismo
Estudio de Mercado de los Ensayos Clínicos en Chile, en Fases I, II, III y IV
Estudios acerca del mecanismo molecular de la enfermedad de Parkinson=> Posible papel neuroprotector de DT-diaforasa y GST M2-2 en cultivos celulares y asociacion de coexistencia de polimorfismos de DT-diaforasa y alfa-sinucleina con E.de Parkinson.
Purification and Characterization of a Transformation Factor Secreted by a Rat Thyroid Tumor Cell Line.
Estudios químicos, farmacológicos y toxicológicos de Haplopappus multifolius y H. taeda, conducentes al desarrollo de una Monografía del "bailahuén".
Gene dosage effects in cholinergic and glutamatergic dysfunction of immortalized neuronal cells derived from the trisomy 16 mouse, an animal model of human Down syndrome.
GENE DOSAGE EFFECTS IN CHOLINERGIC AND GLUTAMATERGIC DYSFUNCTION OF IMMORTALIZED NEURONAL CELLS DERIVED FROM THE TRISOMY 16 MOUSE, AN ANIMAL MODEL OF HUMAN DOWN SYNDROME
Rol de genes relacionados con el sindrome de Down en las alteraciones del calcio intracelular en una línea neuronal derivada de corteza cerebral de ratón trisómico 16, modelo animal de la condición humana. Intercambio CNRS/Conicyt .
Modèles cellulaires du syndrome de Down humain => Rôle de la Surexpression génique dans le mauvais fonctionnement neuronal de cellules immortalisées de système nerveux de la souris trisomique 16.
Estudios acerca del mecanismo de toxicidad de o-quinonas derivadas de dopamina y el posible polimorfismo de DT-diaforasa y GST M-2 / M1-1 en enfermos de Parkinson chilenos.
Establishment of a human substantia nigra cell line for use in cell transplant therapy of Parkinson’s disease.
Evaluación de líneas celulares inmortales para transplante celular en el tratamiento de la enfermedad de Parkinson experimental en monos parkinsonizados con MPTP.
Mecanismos de neurotoxicidad y neuroproteccion en modelos animales y celulares de Parkinson. ECOS/Conicyt
LINEAS CELULARES IMPORTANTEAS DERIVADAS DEL SISTEMA NERVIOS RATON CON TRISOMIA 16, MODELO DE LA TRISOMIA 21 HUMANA=>POSIBLES MODELOS FISIOPATOLOGICOS
Líneas celulares inmortales derivadas de sistema nervioso del ratón con trisomía 16, modelo animal de la trisomía 21 humana=> Posibles modelos fisiopatológicos.
MECANISMOS DE ACOPLAMIENTO ENTRE EXCITACION Y TRANSCRIPCION EN CELULAS DE MUSCULO ESQUELETICO
Mecanismos de acoplamiento entre excitación y transcripción en células de músculo esquelético
Señales de Ca2+ en tejido neuronal. , INSERM/Conicyt, Intercambio Chile- Francia
Calcium regulation in nerve and muscle cells.
PARTICIPACION DEL IGF-I EN LA GENESIS Y DESARROLLO DE LA HIPERTROFIA CARDIACA PATOLOGICA EXPERIMENTAL=> ESTUDIO Y MODULACION FARMACOLOGICA DE SUS MECANISMOS DE TRANSDUCCION
Un modelo celular del Sindrome de Down para evaluar las alteraciones de las propiedades eléctricas de la membrana celular en neuronas=> Establecimiento y caracterización de líneas celulares inmortales a partir de tejido neuronal.
Caracterización de líneas celulares humanas de músculo esquelético normal y distrófico.
celulares humanas de músculo esquelético normal y distrófico.
Estudio de actividad eléctrica en el ratón con trisomía 16, modelo animal para la trisomía 21 humana (Sindrome de Down).
Estudio de actividad eléctrica y secreción de sustancias vasoactivas en endotelio en cultivo

Review (2)

Role of Tau Protein in Neuronal Damage in Alzheimer's Disease and Down Syndrome
Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase
124
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

8
Sergio Cárdenas

Coordinador de Investigación e investigador

Centro de Ingeniería y desarrollo sostenible

Universidad Central de Chile

Santiago, Chile

7
Alexies Dagnino

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

5
Patricia Muñoz

Co-investigador

Universidad de Chile

SANTIAGO, Chile

4
Ana Cárdenas

Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

4
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
Daniela Parrau

Profesor asistente

Morfofunción

Universidad Diego Portales

Santiago, Chile

3
Jorge Bevilacqua

Profesor Titular

Neurología y Neurocirugía

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ESCUELA DE MEDICINA

Santiago, Chile

2
CRISTIAN COVARRUBIAS

PROFESOR ASOCIADO

INSTITUTO DE INVESTIGACIÓN EN CIENCIAS ODONTOLÓGICAS

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

2
Brenda Modak

Directora Departamento de Ciencias del Ambiente

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Alvaro Ardiles

Adjunct Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

2
Barbara Andrews

FULL PROFESSOR

CHEMICAL ENGINEERING AND BIOTECHNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Andrónico Neira

Titular Professor

Biological and Animal Science

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Julian Bejarano

Investigador Postdoctoral

Universidad de Chile. Centro FONDAP ACCDiS

Santiago, Chile

2
Alfredo von Marttens

DIRECTOR DE ESPECIALIDAD IMPLANTOLOGÍA BUCO MAXILO FACIAL

PRÓTESIS

ESCUELA GRADUADOS, FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

1
Humberto Palza

Associate Professor

Departamento de Ingeniería Química y Biotecnología

Universidad de Chile

Santiago, Chile

1
Arlek Gonzalez

INVESTIGADOR POST-DOCTORAL

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA, UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Gonzalo Jorquera

Profesor Auxiliar

Instituto de Fisiología

Universidad de Valparaíso

Valparaíso, Chile

1
patricia palma

Académico

Departamento de Patología y Medicina Oral

Universidad de Chile

santiago, Chile

1
Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

1
Luis Meléndez

Jefe de Taller para adultos mayores

Oficina de Pensionados y Montepiadas del ex Servicio de Seguro Social

Oficina de Pensionados y Montepiadas del ex Servicio de Seguro Social

Valparaiso, Chile

1
Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Fernando Hinostroza

Profesor part-time

Ciencias básicas

Universidad Católica del Maule

Talca, Chile

1
CLAUDIA JARA

Asistente de Investigación

Universidad Austral de Chile

valdivia, Chile

1
Camila Corral

Assistant Professor

Restorative Dentistry

Universidad de Chile

Santiago, Chile

1
Claudio Cappelli

Technical Laboratory Manager

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Melissa Calegaro

Investigadora Principal

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

1
Cesar Astorga

Postdoctorado

Cs Biomedicas

Universidad Andrés Bello

Santiago, Chile

1
Ricardo Delgado

Profesor Adjunto

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGIA

Santiago, Chile

1
Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

1
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

1
Marilyn Paz

academico

Facultad de Medicina

Universidad de Valparaiso

Viña del Mar, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
Carlos Jara

Jefe de Laboratorio - Estrés Oxidativo

Universidad de Valparaíso

Reñaca, Chile