CERAMIC NANOMATERIALS; HYBRID NANOCOMPOSITE BIOMATERIALS; mecanisms of neurodegeneration ; Down syndrome, cell therapy, stem cell differentiation, tissue microencapsulation; Modification of Natural Polymers Biomimetic; Bio-related Materials;

Thesis directed (2007 – present. 15 prior to 2007)

1.- Ongoing:

- Christian Arriagada. PhD Thesis, PhD program in Biomedical Sciences, Fac. of Medicine, Univ. of Chile. Autophagy in neuronal cell lines established from a mouse model of Down syndrome
- Claudia Jara Cancino. Thesis Director, PhD in Pharmacology, Faculty of Chemistry & Pharmacy, Univ. of Chile. Microencapsulation of spherical cell aggregates of ? and ? cells, differentiated from human adipose tissue derived mesenchymal stem cells.
- Natalia Barraza Thesis Director, PhD in Pharmacology, Faculty of Chemistry & Pharmacy, Univ. of Chile.. Eff of overexpressed APP on PAK activity sand actin filament ploymerization in a celular model of Down symdrome
- Belén Gaete, Thesis Director, Bs degree in Biochemstry, Pontificial Catholic Univ. of Valparaíso, Chile.. Phamacological modulation of P21- Activated kinases (PAK) in an in vitro neuronal model of Down syndrome: Consequnces on process growth and branching.

2.- Finished
- Ramón Pérez Nuñez. Thesis Director, Thesis Director, PhD in Biochemistry, Faculty of Chemistry & Pharmacy, Univ. of Chile.. Effect of DSCAM overexpression on morphological parameters in cell models of Down síndrome: the role of the P21- Activated kinases (PAK) pathway. Possible examination date: August 2016
Esteban González. PhD Thesis, PhD program in Medical Sciences, Fac. of Medicine, Univ. of Chile. Differentiation of human stem and mesenchimal cells into myocardiocytes: Application to cell transplant in ischemic heart disease. Exam: June 15, 2016
- Paulina Salazar. Thesis Director, MsC in Genetics, Faculty of Medicine, Univ . de Chile. Study of nFATC4 activity in a neuronal cell line derived from a murine model of Down syndrome Exam: June 27, 2015.
- Nicolás Pereira. Thesis Director, MsC in Molec & Cellular Biomedicine, Faculty of Medicine, Univ . de Chile. Effects od differnt cryopreservation media on adipose-derived stem cell viability: Which is the best cryporeservative? Exam: June 30, 2015.
- Ximena Cataldo Thesis Director, MsC in Nutrition, Faculty of Medicine, Univ . de Chile. Neuroprotection induce by ?-cryptoxanthine in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse, and animal model for Down syndrome. Exam: November 3 2014
- Natalia Galarce Toro. Bs degree in Chemical Engineering, Univ.of Chile. Effect of ion release on cell viability in polymeric composites bearing copper nanoparticles. Exam: Dicembe 2013.
- Macarena Beltrán Carpentier. Bs degree in Chemical Engineering, Univ.of Chile. Study on the biocompatibility of plymeric composites bearing coppr nanoparticles. Exam: June 2013.
- Natalia Barraza: Contribution of DSCR1 to tau protein hyperphosphorilation in trisomy 21. MsC in Biological Sci, major in Neuroscience. U. Valparaíso (Co tutor, A.M. Cárdenas). Exam: July 2013
Mario Acuña. Msc Thesis codirector (with C. Arriagada). Effect of RCAN1 overexpression on Ca2+ currents in a cell line derived from the cerebral cortex of a trisomy 16 mouse; an animal un model of Down Syndrome. Fac. Of Sciences. U. of Chile. Exam: January 2012.
- Jura Mikkola. Thesis director, MSc in Neuroscience. University of Jyväskylä, Finland. Effect of Sod1 and Sod1/APP knockdown in cholinergic dysfunction in a neuronal cell line derved from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome. Exam: July 2008.
- Adriana Armijo. Thesis director, MSc in Neuroscience, Faculty of Medicine, Univ. of Chile. Characterization of a cell line derived from the primary motor cortex off an adult rat: A model for cell transplant therapy in rats submitted to cerebral ischemia. Exam: March 2008
- Patricio Cabané Toledo. Thesis director, PhD in Medical Sciences, Faculty of Medicine, Univ. of Chile. Optimization of culture conditions for parathyroid cells: Use in cell transplant therapy in hypoparathyroidism. Exam: January 2008
- Ignacio Díaz Franulic. Thesis director, Degree in Biochemistry, University of Chile. Effect of Slc5a3 (SMIT1, myo-inositol cotransporter) knockdown in cholinergic dysfunction of a cell line derived from the brain of a trisomy 16 mouse, an animal model of Down syndrome. Exam: December, 2007.
- Paola Fernández Olivares. Thesis codirector (with A.M. Cárdenas), Degree in Biochemistry, Catholic University of Valparaiso. Effect of Slc5a3 (SMIT1, myo-inositol cotransporter) knockdown in Ca2+ signaling in a cell line derived from the brain of a trisomy 16 mouse, an animal model of Down syndrome. Exam: June 29, 2007.

Tutorships, Research Units: Rodrigo Carrasco (PhD Program in Medical Sciences, Fac. of Medicine,, Univ. of Chile , 2007). Rodrigo Nieto (PhD Program in Medical Sciences, Fac. of Medicine,, Univ. of Chile , 2007). Dario Vázquez (PhD Program in Medical Sciences, Fac. of Medicine,, Univ. of Chile , 2007). Jorge Noriega(PhD Program in Biomedical Sciences, Fac. of Medicine,, Univ. of Chile , 2009). Mario Acuña (MsC Program, Faculty of Science, Univ. de Chile., 2010)

Teaching, graduate courses:
-Professor, Graduate course, Introduction to Neuroscience, Fac. of Medicine, Univ. de Chile. 2007- present.
-Professor, Graduate course, Systems physiology. Fac. of Medicine, Univ. de Chile. 2007- present.
-Professor, Graduate course,, Physical activity Physiology. Fac. of Medicine, Univ. de Chile. 2007- 2009.
-Professor & coordinator, Internacional course: “Molecular & Cellular Mechanisms of Neuronal Damage. Therapeutical approaches”. March 23 - 25, 2007 (Pucón, Chile), and April 23 -26 de Abril, 2009 (Arica, Chile)
- Professor, MsC program Biological Sciences, Univ. of Valparaíso (2007). Topic:: “Cellular and trophic factor therapy in neurodegenerative pathology”
Bibliographic seminars, mechanisms of neurodegenerative pathology (Coord. Claudio Hetz) (2009 – 2010)

Member PhD in Pharmacology , Committee, Faculty of medicine and Faculty of Chemistry & Pharmacy, Fac of Medicine, Univ of Chile. Since January 2014.

PAPERS PRIOR TO 1995:

- Fiedler, J., Rapoport, S.I., Epstein, C.J., Caviedes, R. and Caviedes, P. Altered cholinergic function in cultured neurons from the trisomy 16 mouse fetus, a model for Down Syndrome. Brain Res., 658 (1994), 27-32.

- Caviedes, P., Caviedes, R., Liberona, J.L. and Jaimovich, E. Ion currents in a skeletal muscle cell line from a Duchenne muscular dystrophy patient. Muscle & Nerve. 17 (1994), 1021-1028.

- Vargas, F. F., Caviedes, P. and Grant, D. S.. Electrophysiological characteristics of cultured human umbilical vein endothelial cells. Microvasc. Res. 47 (1994), 153-165.

- Caviedes, P., Olivares, E., Salas, K., Caviedes, R. and Jaimovich, E.. Calcium fluxes, ion currents and dihydropyridine receptors in a newly established cell line from rat heart muscle. J. Molec. & Cell Cardiol. (1993), 25 (1993), 829-845.

- Caviedes, P., Koistinaho, J., Ault, B. and Rapoport, S. I.. Effects of nerve growth factor on the electrical membrane properties of cultured dorsal root ganglia neurons from normal and trisomy 21 human fetuses. Brain Res., 556 (1991), 285-291.

- Caviedes, P., Ault, B. and Rapoport, S. I.. A replated culture preparation improves whole cell voltage clamp conditions of human fetal sensory neurons. J. Neurosci. Meth., 35 (1990), 57-61.

- Caviedes, P., Ault, B. and Rapoport, S. I.. Electrical membrane properties of cultured dorsal root ganglion neurons from trisomy 19 mouse fetuses: a comparison with the trisomy 16 mouse fetus, a model for Down syndrome. Brain Res., 511 (1990) 169-172.

- Caviedes, P., Ault, B. and Rapoport, S. I.. The role of altered sodium currents in the action potential abnormalities of cultured dorsal root ganglion neurons from trisomy 21 (Down syndrome) human fetuses. Brain Res., 510 (1990) 229-236.

- Ault, B., Caviedes, P., Hidalgo, J., Epstein, C.J. and Rapoport, S. I.. Electrophysiological analysis of cultured fetal mouse dorsal root ganglion neurons transgenic for human superoxide dismutase-1, a gene in the obligate Down syndrome region of chromosome 21. Brain Res., 497 (1989) 191-194.

- Ault, B., Caviedes, P. and Rapoport, S. I.. Neurophysiological abnormalities in cultured dorsal root ganglion neurons from the trisomy 16 mouse fetus, a model for Down Syndrome. Brain Res., 485 (1989) 165-170.

PATENTS

1.- Freeman, TB, Caviedes, P., Caviedes, R. Conditioned medium and Proliferated Cell Lines Produced Therefrom. Pub US 2008/0175828 A1, Date: Dec 25, 2012. US Patent No US 8.337.829 B2..

2.- Freeman, TB, Caviedes, P., Caviedes, R. Proliferated Cell Lines and Uses Thereof. Japanese patent number 4.741.189. Filed Feb 7, 2003. Granting date: May 13, 2011.

3.- Caviedes, P., Caviedes, R., Freeman, TB, Asenjo, J., Andrews, B., Sepúlveda, D, Arriagada, C. y Salazar Rivera, J.. Materials and Methods for Regulating Process Formation in Cell Culture. US Patent, Letters, US 7.323.333 B2, Date: Jan 29, 2008. Pub. US Patent No 8,252,279, 8 Agosto 2012.

4.- Caviedes, P., Caviedes, R., Freeman TB, Sanberg, PR., Cameron DF. Proliferated Cell Lines and Uses Thereof. Canada Application No 2.476.214. Filed 2/7/2003, number pending.

5.- Cameron, DF, Caviedes, P., Caviedes R., Freeman, TB, Sanberg, PR. Proliferated cell Lines and uses thereof. Europe application EP 157524 (A2). Pub Date Sept 21, 2005. Number pending.