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Alvaro Oscar Ardiles Araya

Assistant Professor

Universidad de Valparaíso

Valparaiso, Chile

Líneas de Investigación


Neuroscience, Synaptic physiology, Behavioral neuroscience, Neuromodulation, Aging and Neurodegeneration, Panexin 1 channels activity, Molecular mechanisms of Synaptopathies, Alzheimer´s disease, neuronal cytoskeleton.

Educación

  •  Neuroscience, UNIVERSIDAD DE VALPARAISO. Chile, 2011
  •  Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2006
  •  Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2005

Experiencia Académica

  •   Assistant professor Full Time

    UNIVERSIDAD DE VALPARAISO

    MEDICINA

    Valparaiso, Chile

    2017 - A la fecha

  •   Lecturer professor Other

    Universidad Andrés Bello

    Ciencias Biológicas

    Viña del mar, Chile

    2011 - 2012

Experiencia Profesional

  •   Young associate researcher Part Time

    Centro Interdisciplinario de Neurociencia

    Valparaiso, Chile

    2015 - 2020

  •   Postdoctoral researcher Full Time

    Universidad de Valparaiso

    Valparaiso, Chile

    2012 - 2015

  •   Lecturer professor Other

    Universidad Andres bello

    Valparaiso, Chile

    2011 - 2012

  •   Research assistant Full Time

    Centro Interdisciplinario de Neurociencia

    Valparaiso, Chile

    2005 - 2007

  •   Adjunct researcher Part Time

    Centro Interdisciplinario de Neurociencia de Valparaiso

    Valparaiso, Chile

    2021 - A la fecha

Formación de Capital Humano


3 PhD thesis, 3 Master Thesis and 5 Undergraduate thesis directed or co-directed.
Undergraduate
2013-2014 (Biotechnology) Oriana Ramírez Herrera. Universidad Andrés Bello
2015-2016 (Biochemistry) Francisca García Rojas. Pontificia Universidad Católica de Valparaíso.
2018-2019 (Medical technologist) Barbara Gomez and Elena Mery. Universidad de Valparaiso
2019-2020 (Medical technologist) Nicolas Rivera. Universidad de Valparaiso
MsC
2013-2014 (MSc in Biotechnology) Oriana Ramírez Herrera. Universidad Andrés Bello
2014-2016 (MSc in Neuroscience) Carolina Flores Muñoz. Universidad de Valparaíso.
2016-2017 (MSc in Neuroscience) Luis Manriquez Cockbaine. Universidad de Valparaíso.
2020- (MSc in Cellular & Molecular Biology) Gonzalo Poblete. Universidad de Valparaíso.
PhD
2018- (PhD in Neuroscience) Carolina Flores Muñoz. Universidad de Valparaíso.
2018- (PhD in Neuroscience) Francisca García Rojas. Universidad de Valparaíso.
2019- (PhD in Neuroscience) Paula Mujica Covarrubias. Universidad de Valparaíso.
2020- (PhD in Neuroscience) Javiera Illanes. Universidad de Valparaíso.


Premios y Distinciones

  •   Postdoctoral fellow FONDECYT

    FONDECYT

    Chile, 2013

    Role of pannexin1 in synaptic physiology. ID 3130759 This grant seeks to investigate the role of pannexin1 in synaptic function and plasticity in the hippocampus from mice.

  •   Inserción de Capital Humano Avanzado en la Academia CONICYT

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2015

    Panexina 1: un nuevo actor en los mecanismos patológicos asociados a la enfermedad de Alzheimer. ID 79150045

  •   CINV Postdoctoral fellowship

    Centro Interdisciplinario de Neurociencia de valparaiso

    Chile, 2012

    The purpose of this program is to support outstanding and highly motivated PhD graduates from any country who wish to initiate or continue a scientific project in one of CINV’s labs.


 

Article (22)

Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease
Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation
Dynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease
Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus
Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease
Lack of Pannexin 1 Alters Synaptic GluN2 Subunit Composition and Spatial Reversal Learning in Mice
IRE1 signaling exacerbates Alzheimer's disease pathogenesis
Molecular and Cellular Mechanisms of Synaptopathies
Genetic variants associated with neurodegenerative Alzheimer disease in natural models
Inhibition of DNA Methylation Impairs Synaptic Plasticity during an Early Time Window in Rats
Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the Hippocampus
Regulation of Memory Formation by the Transcription Factor XBP1
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus
Pannexin 1 regulates bidirectional hippocampal synaptic plasticity in adult mice
Integrity of mGluR-LTD in the Associative/Commissural Inputs to CA3 Correlates with Successful Aging in Rats
Octodon degus (Molina 1782): A model in comparative biology and biomedicine
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease
Pull-Push Neuromodulation of LTP and LTD Enables Bidirectional Experience-Induced Synaptic Scaling in Visual Cortex
The elusive crypt olfactory receptor neuron: evidence for its stimulation by amino acids and cAMP pathway agonists
Calcium channel subtypes differentially regulate fusion pore stability and expansion
A rapid exocytosis mode in chromaffin cells with a neuronal phenotype

BookSection (1)

Redox Homeostasis in Neural Plasticity and the Aged Brain

Proyecto (11)

Over-activation of Panx1 in neurons leads to intracellular Ca2+ overload and subsequent defects in neuronal cytoskeleton and signaling receptor trafficking supporting synaptic defects in an Alzheimer´s disease model
Role of promigratory activation of VEGFR2 in the brain angiogenesis and its potential implication in learning and memory of offspring born to preeclampsia
Panexina 1=> un nuevo actor en los mecanismos patológios asociados a la enfermedad de Alzheimer
Proteostaser-1=> una terapia génica enfocada a disminuir la neurodegeneración y aumentar la función cognitiva en la enfermedad de Alzheimer.
A NOVEL ROLE OF PANNEXIN 1 CHANNELS IN THE SYNAPTOPATHY ASSOCIATED TO THE SOLUBLE AMYLOID ? OLIGOMERS IN ALZHEIMER´S DISEASE
ASTAXANTINA Y ANTIENVEJECIMIENTO CEREBRAL
ROL DE PANEXIN 1 EN LA FISIOLOGIA SINAPTICA.
Centro de neurociencia sensorial desde la señal de transducción hasta el código neural
GENE DOSAGE EFFECTS IN CHOLINERGIC AND GLUTAMATERGIC DYSFUNCTION OF IMMORTALIZED NEURONAL CELLS DERIVED FROM THE TRISOMY 16 MOUSE, AN ANIMAL MODEL OF HUMAN DOWN SYNDROME
CAMBIOS EN LA EFICIENCIA SECRETORA DEBIDO A REDISTRIBUCION DE ZONAS SECRETORAS ACTIVAS Y CANALES CALCIO EN CELULAS CROMAFINES DIFERENCIADAS
CAMBIOS EN LA EFICIENCIA SECRETORA DEBIDO A REDISTRIBUCION DE ZONAS SECRETORAS ACTIVAS Y CANALES CALCIO EN CELULAS CROMAFINES DIFERENCIADAS

Review (2)

Alzheimer's disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers
Role of Tau Protein in Neuronal Damage in Alzheimer's Disease and Down Syndrome
30
Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

11
Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

4
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

2
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

2
Joaquìn Araya

Profesor

Facultad de Salud

Universidad Santo Tomás

Santiago, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
Arlek Gonzalez

INVESTIGADOR POST-DOCTORAL

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA, UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

1
Juan Zolezzi

Associate Professor

School of Medicine

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Pablo Muñoz

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Paula Diaz

PhD (c)

Departamento de Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Pablo Lizana

Profesor Adjunto - Jornada Completa

Instituto de Biología

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

1
Juvenal Rios

Subdirector Observatory of Health Innovation

Colegio Médico de Chile A.G.

Santiago, Chile

1
Pablo Mardones

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Alex Vielma

Postdoctoral researcher

Centro Interdisciplinario de Neurociencias de Valparaíso

Valparaiso, Chile

1
Luz Delgado

Investigador

Fundacion Ciencia para la vida

Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Francisco Bozinovic

Full professor

Ecology

Pontifical Catholic University of Chile

Santiago, Chile

1
Ana Cárdenas

Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Oliver Schmachtenberg

Investigador titular

Instituto de Biología

Universidad de Valparaíso, CINV

Valparaíso, Chile

1
Maria Yolanda Espinosa

Associate Professor

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

1
Claudia Duran-Aniotz

Profesor Asistente

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

1
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile