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Juan Manuel Zolezzi Moraga

Associate Professor

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

Molecular basis of chronic degenerative diseases; Molecular basis of Neurodegenerative disorders and Neuroinflammation; Molecular Neurobiology; Wnt Signaling and Synaptic function; Nuclear receptors

Biotechnology, Pharmacology and Toxicology, UNIVERSITA DEGLI STUDI DI BOLOGNA. Italia, 2012
Veterinary Physician, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007

Instructor Full Time

UNIVERSIDAD DE TARAPACA

Sciences

Arica, Chile

2013 - 2016
Associate Professor Full Time

UNIVERSIDAD DE MAGALLANES

Health Sciences

Punta Arenas, Chile

2019 - A la fecha

PostDoc Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2012 - 2013
Instructor Full Time

Universidad de Tarapacá

Arica, Chile

2013 - 2016
Researcher Full Time

Pontifica Universidad Católica de Chile

Santiago, Chile

2016 - 2019
Associate Professor Full Time

Universidad de Magallanes

Punta Arenas, Chile

2019 - A la fecha

During PhD formation, at the University of Bologna, I followed four undergraduate students. In the same way, at the University of Tarapacá, I followed two undergraduate students and one magister student. Now, at the University of Magallanes, I have two Doctorate candidates ready to work with me.


Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus Lindsay, Carolina B.; Zolezzi, Juan M.; Rivera Daniela S.; Cisternas, Pedro; Bozinovic, Francisco; Inestrosa, Nibaldo C. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2020)
Wnt Signaling Pathway Dysregulation in the Aging Brain: Lesson From the Octodon Degus Inestrosa, Nibaldo C; Tapia-Rojas Cheril; Lindsay, Carolina B; Zolezzi, Juan Manuel Article ISI SCOPUS Frontiers in Cell and Developmental Biology (2020)
Diterpenes and the crosstalk with the arachidonic acid pathways, relevance in neurodegeneration Zolezzi, Juan M.; Inestrosa, Nibaldo C. Article ISI SCOPUS NEURAL REGENERATION RESEARCH (2019)
Wnt Signaling Upregulates Teneurin-3 Expression via Canonical and Non-canonical Wnt Pathway Crosstalk Bastías-Candia, S; Martinez, M; Zolezzi, JM; Inestrosa, NC Article ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2019)
Neuroprotective Effects of Ferruginol, Jatrophone, and Junicedric Acid Against Amyloid-beta Injury in Hippocampal Neurons Zolezzi, Juan M.; Lindsay, Carolina B.; Serrano, Felipe G.; Ureta, Roxana C.; THEODULOZ, CRISTINA; Schmeda-Hirschmann, Guillermo; Inestrosa, Nibaldo C Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2018)
New Insights into the Spontaneous Human Alzheimer's Disease-Like Model Octodon degus: Unraveling Amyloid-? Peptide Aggregation and Age-Related Amyloid Pathology Cisternas P.; Zolezzi J.M.; Lindsay C.; Rivera D.S.; Martinez A.; Bozinovic F.; Inestrosa, N. C. Article ISI SCOPUS (2018)
Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease Cisternas P.; Zolezzi J.M.; Martinez M.; Torres V.I.; Wong G.W.; Inestrosa, N. C. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2018)
INT131 increases dendritic arborization and protects against A beta toxicity by inducing mitochondrial changes in hippocampal neurons Godoy, Juan A.; Zolezzi, Juan M.; Inestrosa, Nibaldo C. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation Zolezzi, Juan M.; Santos, Manuel J.; Bastías-Candia, Sussy; Pinto, Claudio; Godoy, Juan A.; Inestrosa, Nibaldo C. Article ISI SCOPUS BIOLOGICAL REVIEWS (2017)
PPARs in the central nervous system=> roles in neurodegeneration and neuroinflammation. Zolezzi, Juan M; Santos, Manuel J; Bastías-Candia, Sussy; Pinto, Claudio; Godoy, Juan A; Inestrosa, Nibaldo C Article Biological reviews of the Cambridge Philosophical Society (2017)
Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer's Disease Zolezzi, Juan M.; Inestrosa, Nibaldo C. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2017)
Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer's Disease. Zolezzi, Juan M; Inestrosa, Nibaldo C Article Frontiers in immunology (2017)
Recent advances in neuroinflammation therapeutics: PPARs/LXR as neuroinflammatory modulators Bastías-Candia S.; Nicolás G.A.; Zolezzi J.M.; Inestrosa, N. C. Article SCOPUS CURRENT PHARMACEUTICAL DESIGN (2016)
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease Inestrosa, NC; Rios, JA; Cisternas P.; Tapia-Rojas, C; Rivera, DS; Braidy, N; Zolezzi, JM; Godoy JA; Carvajal, FJ; Ardiles AO; Bozinovic F.; Palacios, AG; Sachdev, PS Article ISI SCOPUS Brain Pathology (2015)
Simultaneous Analysis of SEPT9 Promoter Methylation Status, Micronuclei Frequency, and Folate-Related Gene Polymorphisms: The Potential for a Novel Blood-Based Colorectal Cancer Biomarker Ravegnini, G; Moraga, JMZ; Maffei, F; Musti, M; Zenesini, C; Simeon, V; Sammarini, G; Festi, D; Hrelia, P; Angelini, S Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
Teneurins and Alzheimer's disease: A suggestive role for a unique family of proteins Bastias-Candia, S; Braidy, N; Zolezzi, JM; Inestrosa, NC Article ISI SCOPUS Medical Hypotheses (2015)
Micronucleus frequency in human peripheral blood lymphocytes as a biomarker for the early detection of colorectal cancer risk Maffei, Francesca; Moraga, Juan Manuel Zolezzi; Angelini, Sabrina; Zenesini, Corrado; Musti, Muriel; Festi, Davide; Cantelli-Forti, Giorgio; Hrelia, Patrizia Article ISI MUTAGENESIS (2014)
Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain Godoy, J.A.; Zolezzi J.M.; Braidy, N; Inestrosa, N. C. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2014)
Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease Morroni, Fabiana; Tarozzi, Andrea; Sita, Giulia; Bolondi, Cecilia; Moraga, Juan Manuel Zolezzi; Cantelli-Forti, Giorgio; Hrelia, Patrizia Article ISI NEUROTOXICOLOGY (2013)
Peroxisome Proliferator-Activated Receptor (PPAR) gamma and PPAR alpha Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders? Zolezzi, Juan M.; Silva-Alvarez, Carmen; Ordenes, Daniela; Godoy, Juan A; Carvajal, Francisco J.; Santos, Manuel J.; Inestrosa, Nibaldo C; Ferreira, Sergio T. Article ISI SCOPUS PLOS ONE (2013)
Peroxisome Proliferators Reduce Spatial Memory Impairment, Synaptic Failure, and Neurodegeneration in Brains of a Double Transgenic Mice Model of Alzheimer's Disease Inestrosa, NC; Carvajal, FJ; Zolezzi, JM; Tapia-Rojas, C; Serrano, F; Karmelic D; Toledo EM; Toro, A.; Toro, J.; Santos MJ Article ISI SCOPUS Journal of Alzheimer's Disease (2013)
Tetrahydrohyperforin Decreases Cholinergic Markers associated with Amyloid-beta Plaques, 4-Hydroxynonenal Formation, and Caspase-3 Activation in A beta PP/PS1 Mice Carvajal, FJ; Zolezzi, JM; Tapia-Rojas, C; Godoy JA; Inestrosa, NC Article ISI SCOPUS Journal of Alzheimer's Disease (2013)
Tetrahydrohyperforin Induces Mitochondrial Dynamics and Prevents Mitochondrial Ca2+ Overload after A beta and A beta-AChE Complex Challenge in Rat Hippocampal Neurons Zolezzi, JM; Carvajal, FJ; Rios, JA; Ordenes, D; Silva-Alvarez, C; Godoy JA; Inestrosa, NC Article ISI SCOPUS Journal of Alzheimer's Disease (2013)
Plasma antioxidant enzymes and clastogenic factors as possible biomarkers of colorectal cancer risk Maffei, Francesca; Angeloni, Cristina; Malaguti, Marco; Moraga, Juan Manuel Zolezzi; Pasqui, Francesca; Poli, Carolina; Colecchia, Antonio; Festi, Davide; Hrelia, Patrizia; Hrelia, Silvana Article ISI MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)


Comprehensive overview of Alzheimer’s disease neurodegeneration, from amyloid-beta to neuroinflammatory modulation. Zolezzi, JM; Inestrosa, NC; Aranda Abreu, GE BookSection
Molecular basis of neurodegeneration, lessons from Alzheimer’s and Parkinson’s diseases Zolezzi, JM; Bastías-Candia, S; Inestrosa, NC; Borreca, A BookSection
Toll-like receptors (TLRs) in neurodegeneration: integrative approach to TLRs-cascades in Alzheimer and Parkinson diseases. Zolezzi, JM; Bastías-Candia, S; Inestrosa, NC; Rezaei, N BookSection


High diet, microbiota and neuroinflammation the progression of Alzheimer's disease (FATZHEIMER) EU – LAC HEALTH CONICYT CHILE – EU AND LATIN AMERICA CARIBBEAN CONVOCATORIA 2016, FONDEF - FONIS (T010131) Proyecto 2018-2021 Investigador(a)
Mechanistic insights into Alzheimer’s disease=> epigenetic and immunomodulatory remodelling of endocannabinoid signalling (MIADES) EU – LAC HEALTH CONICYT CHILE – EU AND LATIN AMERICA CARIBBEAN CONVOCATORIA 2016, FONDEF - FONIS (T010132) Proyecto 2018-2021 Investigador(a)
Peroxisome proliferator-activated receptors (PPARs) as potential targets against oxidative stress-derived damge on the blood-brain barrier=> limiting neurodegenerative disorders collateral damage FONDECYT (11130033) Proyecto 2013-2015 Inv. Responsable


Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model Bastias-Candia, S; Zolezzi, JM; Inestrosa, NC Review ISI SCOPUS MOLECULAR NEUROBIOLOGY (2019)
Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-beta brain balance and the putative role of PPARs Zolezzi, JM; Bastias-Candia, S; Santos MJ; Inestrosa, NC Review ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2014)
Brain metabolite clearance: impact on Alzheimer's disease Zolezzi, JM; Inestrosa, NC Review ISI METABOLIC BRAIN DISEASE (2014)
Signaling pathway cross talk in Alzheimer's disease Godoy JA; Rios, JA; Zolezzi, JM; Braidy, N; Inestrosa, NC Review ISI SCOPUS CELL COMMUNICATION AND SIGNALING (2014)
Peroxisome Proliferator-activated Receptors and Alzheimer's Disease: Hitting the Blood-Brain Barrier Zolezzi, JM; Inestrosa, NC Review ISI SCOPUS Molecular Neurobiology (2013)