Man

Juan Manuel Zolezzi Moraga

Associate Professor

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

Líneas de Investigación


Molecular basis of chronic degenerative diseases; Molecular basis of Neurodegenerative disorders and Neuroinflammation; Molecular Neurobiology; Wnt Signaling and Synaptic function; Nuclear receptors

Educación

  •  Biotechnology, Pharmacology and Toxicology, UNIVERSITA DEGLI STUDI DI BOLOGNA. Italia, 2012
  •  Veterinary Physician, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007

Experiencia Académica

  •   Instructor Full Time

    UNIVERSIDAD DE TARAPACA

    Sciences

    Arica, Chile

    2013 - 2016

  •   Associate Professor Full Time

    UNIVERSIDAD DE MAGALLANES

    Health Sciences

    Punta Arenas, Chile

    2019 - A la fecha

Experiencia Profesional

  •   PostDoc Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2012 - 2013

  •   Instructor Full Time

    Universidad de Tarapacá

    Arica, Chile

    2013 - 2016

  •   Researcher Full Time

    Pontifica Universidad Católica de Chile

    Santiago, Chile

    2016 - 2019

  •   Associate Professor Full Time

    Universidad de Magallanes

    Punta Arenas, Chile

    2019 - A la fecha

Formación de Capital Humano


During PhD formation, at the University of Bologna, I followed four undergraduate students. In the same way, at the University of Tarapacá, I followed two undergraduate students and one magister student. Now, at the University of Magallanes, I have two Doctorate candidates ready to work with me.



 

Article (24)

Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus
Wnt Signaling Pathway Dysregulation in the Aging Brain: Lesson From the Octodon Degus
Diterpenes and the crosstalk with the arachidonic acid pathways, relevance in neurodegeneration
Wnt Signaling Upregulates Teneurin-3 Expression via Canonical and Non-canonical Wnt Pathway Crosstalk
Neuroprotective Effects of Ferruginol, Jatrophone, and Junicedric Acid Against Amyloid-beta Injury in Hippocampal Neurons
New Insights into the Spontaneous Human Alzheimer's Disease-Like Model Octodon degus: Unraveling Amyloid-? Peptide Aggregation and Age-Related Amyloid Pathology
Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease
INT131 increases dendritic arborization and protects against A beta toxicity by inducing mitochondrial changes in hippocampal neurons
PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation
PPARs in the central nervous system=> roles in neurodegeneration and neuroinflammation.
Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer's Disease
Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer's Disease.
Recent advances in neuroinflammation therapeutics: PPARs/LXR as neuroinflammatory modulators
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease
Simultaneous Analysis of SEPT9 Promoter Methylation Status, Micronuclei Frequency, and Folate-Related Gene Polymorphisms: The Potential for a Novel Blood-Based Colorectal Cancer Biomarker
Teneurins and Alzheimer's disease: A suggestive role for a unique family of proteins
Micronucleus frequency in human peripheral blood lymphocytes as a biomarker for the early detection of colorectal cancer risk
Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain
Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease
Peroxisome Proliferator-Activated Receptor (PPAR) gamma and PPAR alpha Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders?
Peroxisome Proliferators Reduce Spatial Memory Impairment, Synaptic Failure, and Neurodegeneration in Brains of a Double Transgenic Mice Model of Alzheimer's Disease
Tetrahydrohyperforin Decreases Cholinergic Markers associated with Amyloid-beta Plaques, 4-Hydroxynonenal Formation, and Caspase-3 Activation in A beta PP/PS1 Mice
Tetrahydrohyperforin Induces Mitochondrial Dynamics and Prevents Mitochondrial Ca2+ Overload after A beta and A beta-AChE Complex Challenge in Rat Hippocampal Neurons
Plasma antioxidant enzymes and clastogenic factors as possible biomarkers of colorectal cancer risk

BookSection (3)

Comprehensive overview of Alzheimer’s disease neurodegeneration, from amyloid-beta to neuroinflammatory modulation.
Molecular basis of neurodegeneration, lessons from Alzheimer’s and Parkinson’s diseases
Toll-like receptors (TLRs) in neurodegeneration: integrative approach to TLRs-cascades in Alzheimer and Parkinson diseases.

Proyecto (3)

High diet, microbiota and neuroinflammation the progression of Alzheimer's disease (FATZHEIMER)
Mechanistic insights into Alzheimer’s disease=> epigenetic and immunomodulatory remodelling of endocannabinoid signalling (MIADES)
Peroxisome proliferator-activated receptors (PPARs) as potential targets against oxidative stress-derived damge on the blood-brain barrier=> limiting neurodegenerative disorders collateral damage

Review (5)

Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model
Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-beta brain balance and the putative role of PPARs
Brain metabolite clearance: impact on Alzheimer's disease
Signaling pathway cross talk in Alzheimer's disease
Peroxisome Proliferator-activated Receptors and Alzheimer's Disease: Hitting the Blood-Brain Barrier
30
Juan Zolezzi

Associate Professor

School of Medicine

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

21
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

5
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

3
Juvenal Rios

Subdirector Observatory of Health Innovation

Colegio Médico de Chile A.G.

Santiago, Chile

2
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Sussy Bastías

Profesor Asociado

Universidad de Magallanes

Punta Arenas, Chile

1
Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile