Man

Cheril Cecilia Tapia Rojas

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Aging, Mitochondrial function, Alzheimer Disease; Wnt signaling in the Adult Nervous System, hippocampal learning and memory.

Educación

  •  Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2013
  •  Doctorado en Ciencias Biologicas, Mención en Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile
  •  Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2011

Experiencia Académica

  •   undergraduate thesis student Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    2009 - 2011

  •   PhD student Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Chile

    2015 - 2016

  •   Post-Doctoral research Full Time

    Universidad Autónoma de Chile

    Ciencias Biológicas

    Chile

    2016 - A la fecha

Experiencia Profesional

  •   Profesor ayudante PENTA UC

    Pontificia Universidad Catolica de Chile (PENTA UC)

    Chile

    2009 - 2012

  •   Alumno en práctica

    LABORATORIO CLINICO BIONET ACHS/ARAUCO SALUD/INDISA, EN LA CIUDAD DE ILLAPEL

    Chile

    2009 - 2009

  •   Profesor ayudante Curso BIO274E

    P. Universidad Católica de Chile

    Chile

    2013 - 2014

  •   Profesor particular de Ciencias Part Time

    Home Teachers

    Chile

    2013 - 2015

  •   Profesor Part Time

    Universidad Bernardo O'Higgins

    Chile

    2014 - 2015

  •   Profesor Part Time

    PreUniversitario

    Chile

    2015 - A la fecha

Formación de Capital Humano


Función de las Mitocondrias Sinápticas y su Implicancia en la Pérdida de Memoria durante el Envejecimiento, Margrethe Olesen, Magister en Neurociencia, Universidad Autónoma.

Disfunción de las mitocondrias sinápticas y su relación con el péptido Beta- Amiloide (A?) en la enfermedad de Alzheimer. Fabián Alarcón, Magister en Neurociencia, Universidad Autónoma.



 

Article (43)

Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice
Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D
Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus
Hormetic-like effects of l-homocysteine on synaptic structure, function, and A? aggregation
Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics
Wnt Signaling Pathway Dysregulation in the Aging Brain: Lesson From the Octodon Degus
Adolescence binge alcohol consumption induces hippocampal mitochondrial impairment that persists during the adulthood
GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies
It’s all about tau
Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment (vol 55, pg 4473, 2018)
Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus
Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimers disease in J20-APP transgenic and wild-type mice
Possible role of mitochondrial permeability transition pore in the pathogenesis of Huntington disease.
Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-? (A?) 42 peptides
Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AβPPswe/PS-1 Mice of Different Ages
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease.
Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy
Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy.
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus
Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3 beta=> autoregulation of GSK-3 beta in vivo
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus.
beta-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice.
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?=> Changes in A beta oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice
Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy
β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats.
Andrographolide reduces cognitive impairment in young and mature A beta PPswe/PS-1 mice
Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice.
Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.
Peroxisome Proliferators Reduce Spatial Memory Impairment, Synaptic Failure, and Neurodegeneration in Brains of a Double Transgenic Mice Model of Alzheimer's Disease
Peroxisome proliferators reduce spatial memory impairment, synaptic failure, and neurodegeneration in brains of a double transgenic mice model of Alzheimer's disease.
Tetrahydrohyperforin Decreases Cholinergic Markers associated with Amyloid-beta Plaques, 4-Hydroxynonenal Formation, and Caspase-3 Activation in A beta PP/PS1 Mice
Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-β plaques, 4-hydroxynonenal formation, and caspase-3 activation in AβPP/PS1 mice.
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease.
Tetrahydrohyperforin prevents cognitive deficit, A beta deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1 Delta E9 model of Alzheimer's disease=> a possible effect on APP processing
Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing.

BookSection (3)

Mitochondrial Dysfunction as a Key Event during Aging: From Synaptic Failure to Memory Loss
Ethanol Consumption Affects Neuronal Function: Role of the Mitochondria
New discoveries on the hyperforin derivative, tetrahydrohyperforin: Closer to an Alzheimer'S disease treatment?

Proyecto (2)

Disfunción Mitocondrial en la Sinapsis Neuronal, Envejecimiento y Neurogeneración
Phosphorylated tau in the synaptic mitochondria and its contribution to cognitive impairment during aging

Review (5)

Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission
Alcohol impairs hippocampal function: From NMDA receptor synaptic transmission to mitochondrial function
It's all about tau
Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimers disease
Alcohol consumption during adolescence: A link between mitochondrial damage and ethanol brain intoxication
26
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

8
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

8
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

5
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

2
Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

2
Patricia Burgos

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

2
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

2
Joaquìn Araya

Profesor

Facultad de Salud

Universidad Santo Tomás

Santiago, Chile

2
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Viviana Cavieres

Postdoctoral Researcher

Medicina y Ciencias

Universidad San Sebastián

Santiago , Chile

1
Claudia Jara

Post Doctoral

CEBICEM

Universidad San Sebastián

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

1
Philippe Pihán

Posdoctorado

Fisiología

Universidad de Chile

Santiago, Chile

1
Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

1
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
Hianara Bustamante

Profesor Adjunto Ad-Honorem

Instituto de Microbiología Clínica

Universidad Austral de Chile

Valdivia, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Juan Zolezzi

Associate Professor

School of Medicine

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Patricio Silva

Investigados Postdoctoral

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

1
Claudio Perez

Profesor Asistente

Departamento de Ciencias Fisiológicas

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Cristina Bertocchi

Assistant Professor

Department of Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudia Yefi

Assistant professor

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
GONZALO MARDONES

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

1
María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

1
CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile