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Claudio Andres Hetz Flores

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Neurociencia; Biologia del Desarrollo; Biologia Molecular; Cellular Stress Related to Protein Misfolding; Cell Signaling and Apoptosis; Neurodegeneration

PhD. In Biomedical Sciences, UNIVERSIDAD DE CHILE. Chile, 2004
Molecular Biotechnology Engineer, UNIVERSIDAD DE CHILE. Chile, 2000
Postdoctoral Research Fellow, HARVARD SCHOOL OF PUBLIC HEALTH. Estados Unidos, 2005

Postdoctoral Research Fellow Other

DANA-FARBER CANCER INSTITUTE

Department of Cancer Immunology & AIDS

Estados Unidos

2004 - 2005
Postdoctoral Research Fellow Other

HARVARD SCHOOL OF PUBLIC HEALTH

Chile

2005 - 2007
Profesor Asistente/ Investigador Principal Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2007 - 2010
Adjunct Professor Other

HARVARD SCHOOL OF PUBLIC HEALTH

Estados Unidos

2009 - 2016
Investigador Asistente Full Time

UNIVERSIDAD DE CHILE

Chile

2015 - A la fecha
Profesor Adjunto Other

THE BUCK INSTITUTE FOR RESEARCH ON AGING

Estados Unidos

2010 - A la fecha
Full Professor and Principal Investigator Full Time

UNIVERSIDAD DE CHILE

Medicina

Chile

2010 - A la fecha
Director Other

Santiago, Chile

2011 - A la fecha

Deputy Director Full Time

Biomedical Neuroscience Institute (BNI)

Santiago, Chile

2011 - A la fecha
Profesor titular Full Time

Universidad de Chile

Santiago, Chile

2010 - A la fecha

(i) Post-doctoral fellows
Dr. Soledad Matus (2007-2012), Dr. Danny Galleguillos (2008-2009), Dr. Rene Vidal (2008-2013); Dr. Andrea Paula (2007-2010; co-advisor); Dr. Karen Castillo (2008-2013), Dr. Gonzalo Encina (2009-2011), Dr. Ute Woehlbier (2010-2014), Dr. Gabriela Mercado (2011-2018), Danilo Bilches (2012-2017), Diego Rojas (2012-2015), Claudia Duran (2013-2017); Pablo Mardones (2013-2017), Paula Huerta (2014-2018); Amado Carreras (2014-2018), Alexis Rivas (2015-2019), Gabriela Martinez (2014-2018), Felipe Cabral (2016-2021), Hery Urra (2016-2018), Vicente Valenzuela (2016-2023), Paulina Falcon (2017-2018), Yannis Gerakis (2017-present), Alfredo Sagredo (2018-2022), Mei-Li Diaz (2019-2022), Philippe Pihan (2018-2024), Younis Hazari (2017-2024), Mateus Milani (2020-2024), Alexis Martinez (2018-2024),

(ii) PhD Thesis
Ph.D. in Biochemistry, University of Chile.
Diego Rojas. (2008-2012) Awarded as Best PhD thesis of Chile, Allende and Connelly Foundation, Chile 2013. Clara Quiroga (2006-2010) (co-advisor). Maria Inés Díaz (2008-2015). Maria Jesus Cerna (2019-2024).

PhD. Biomedical Sciences, University of Chile.
Melissa Calegaro (2007-2012), Mauricio Torres (2007-2013), Gabriela Martinez (2010-2014), Victor Hugo Cornejo (2011-2015), Hery Urra (2011-2014) Awarded as Best PhD thesis of Chile, Chilean Cell Biology Society, Chile 2016 (Federico Leighton Award), Estephanie Dufei (2012-2016), Vicente Valenzuela (2012-2016), Philippe Pihan (2012-2018), Denisse Sepulveda (2013-2018) Awarded as Best PhD thesis of Chile, Chilean Cell Biology Society, Chile 2019. Luis Osorio (2015-2019), Paulina Troncoso (2016-2020), Matias Gonzalez (2016-2020), Celia Limia (2017-2020), Juan Francisco Silvia (2024-Present).

PhD. Medical Sciences, University of Chile.
Lucas Gonzalez (2023-Present), Lene Troncoso (2024-Present).

PhD. Cellular and Molecular Biology, University of Chile.
Pamela Valdés (2008-2013).

Ph.D Pharmacology, University of Chile.
Fernanda Lisbona (2010-2014). Awarded with the Loreal Woman in Science Price (2011) and the RELAB Prize (2012). Rodrigo Perez (2016-2019), Paulina Torres (2017-2021).

PhD in Cellular and Molecular Biology, P. Catholic University of Chile
Alexis Martinez (2012-2016). Co-mentored with Dr Alejandra Alvarez.

PhD in Neurosciences, P. Universidad Católica de Chile.
Maritza Oñate (2013-2018).

PhD in nutrition, University of Chile
María José Hormazábal (2016-2019). Luis Gonzalez (2023-present)

(ii) Master’s students
Master in Biotechnology, Harvard University, USA
Peter Thielen (2010-2011). Awarded with the Dean's Prize for Outstanding ALM Thesis.

Master in Biological Sciences, Faculty of Sciences, University of Chile
Vicente Valenzuela (2009-2010) Awarded as Best Master´s thesis of Chile, Chilean Cell Biology Society, Chile 2012. Andrés Henriquez (2009-2012), Fernanda Lisbona (2007-2008), Maritza Onate (2011-2016) Awarded as Best Master´s thesis of Chile, Chilean Cell Biology Society, Chile 2016, Valentina Castillo (2013-2016), Leslie Bargsted (2013-2016) Pablo Rozas (2014-2018).

Master in Biochemistry, Faculty of Chemistry Sciences, University of Chile.
José Ignacio Astorga (2018-2020)

(iv) Undergraduate Students
Molecular Biotechnology Engineering, Faculty of Science, University of Chile: Sebastian Zamorano (2007-2009), Andrés Henriquez (2007-2009), Vicente Valenzuela (2008-2009), Amparo Zuleta (2010-2011) Catherine Andreu (2011-2012), Leslie Bargted (2012-2013), Valentina Castillo (2012-2014), Martin Sepúlveda (2014-2016).

Biotechnology, Universidad Mayor: Camila Gherardell (2013), Miguel Gonzalez (2014-2015). Biochemistry, University of Chile; Javiera Fernanda Acevedo (2016-2018).

Biotechnology, Universidad Andres Bello. Paloma Moraga (2019-2020). Karina Espinosa (2021-2023).

INTELECTUAL PROPERTY Files: PATENTS and LICENCES

Inventors: Claudio Hetz
Title: Reprogramming Proteostasis Network for Sustaining Brain Function During Aging and Extending Health Span.
U.S. Patent Application No.: 63/631,111.
Filed: April 8, 2024 Ref: 94127.10.USP1. Provisional Application Filed.

Inventors: Claudio Hetz and Laurie Glimcher,
Title: MODULATION OF NEURODEGENERATIVE DISEASE BY MODULATING XBP-1 ACTIVITY. APLLICATION NUMBER: US 13/000,921. PCT number: PCT/US2009/048321.
Publication number US 20110142799 A1 (16/6/2011), also refered as WO2010008860A1.

Inventors: Claudio Hetz and Gabriela Martinez.
Title: AAV/XBP1s-ha virus, gene therapy method and use thereof in the optimisation and improvement of learning, memory and cognitive capacities
Chilean application number: 3590-2014(2014). Submitted date 30/12/2014.
International application number: PCT/CL2015/000069. Submitted date 24/12/2015.
International publication number: WO2016106458. Publication date 7/7/2016.
PCT national phases: USA and EPO.
Status: patent pending.

Inventors: Claudio Hetz and Vicente Valenzuela.
Title: Method for genetic treatment using the AAV-XBP1s/GFP virus and use thereof in the prevention and treatment of amyotrophic lateral sclerosis.
Chilean application number: 201503024 (2015). Submitted date 9/10/2015.
International application number: PCT/CL2016/000056. Submitted date 30/09/2016.
International publication number: WO2017059554A1. Publication date 13/04/2017
PCT national phases: USA, EPO and Australia.
Publication number CY1125031T1.

Inventors: Claudio Hetz and Rene Vidal.
Title: AAV/UPR-plus virus, UPR-plus fusion protein, genetic treatment method and use thereof in the treatment of neurodegenerative diseases, such as parkinson's disease and huntington's disease.
Chilean application number: 3242-2015 (2015). Submitted date 4/11/2015.
International application number: PCT/CL2016/000070. Submitted date 4/11/2016.
International publication number: PCT WO2017075729A1. Publication date 11/05/2017.
PCT national phases: Australia, EPO and Japan.
Publication number US11795476B2.

Inventors: Claudio Hetz and Paula Huerta.
Title: AAV-IGF2 as a genetic method to treat protein misfolding disorders such as Huntington´s disease.
Chilean application number: 20160322(2016). Submitted date 21/12/2016.
International application number: PCT/CL2017/000040. Submitted date 21/12/2017.
International publication number: WO2018112672A. Publication date 28/06/2018.
Status: patent pending.

Inventors: Claudio Hetz, Alexis, Carla del Porte, Marcelo Kogan and Daniela Jara.
Title: Use of leaf extracts from Ugni Molinae for the treatment of protein misfolding disorders.
Chilean application number: 3359-2017(2017). Submitted date 26/12/2017.
Status: patent pending.

Inventors: Claudio Hetz, Felipe Cabral.
Title: Treatment of aging or age-related disorders using XBP1.
Provisional application for patent at USPTO, application number 62800229. Submitted 01/02/2019.
Status: patent pending.

Inventors: Claudio Hetz, Felipe Cabral, Gabriela Martinez, Vicente Valenzuela, Rene Vidal.
Title: liscencing of the use of AAV-XBP1 and UPRplus for the treatment of ALS and parkinson´s disease. Licensed to Handl Therapeutics to develop clinical trials.

Santander Bank Award

Banco Santander

Chile, 2016

For outstanding contributions to University research on the area of neurological diseases
KIA International Award

Iranian Research Organization for Science and Technology

Irán, 2015

First place, for invaluable achievements and contributions to the development of science and technology. In addition, this price was accompanied by an UNESCO special awar
Target Validation Award

Michael J Fox Foundation for Parkinson Research

Estados Unidos, 2014

Para desarrollar terapia genica para el mal de Parkinson.
The Eppendorf & Science Prize for Neurobiology.

Science

Chile, 2008

Selected finalist by the editors of Science magazine as outstanding young scientist.
Highly Ranked Scholars™

Scholar GPS

Estados Unidos, 2024

Selected in the top 0.05% of Highly Ranked Scholars™ for an exceptional performance in various fields, disciplines, and specialties by Scholar GPS™.
Most cited scientist in the world

Clarivate (Web of Science)

Chile, 2023

Awarded by Clarivate (Web of Science) as a “Highly Cited Scientist”, among the TOP 1% most cited scientist in the world
Most cited scientist in Chile

Research.com

Chile, 2023

Selected by Research.com as one of the most cited scientist in Chile in the field.
Highly Cited Scientist

Clarivate (Web of Science)

Chile, 2022

Awarded by Clarivate (Web of Science) as a “Highly Cited Scientist”, among the TOP 1% most cited scientist in the world: https://www.webofscience.com/wos/author/record/2418833
Most cited scientist in Chile

Research.com

Chile, 2022

Selected by Research.com as the most cited scientist in Chile in the field.
Top 2% of most cited scientists

Elsevier and Stanford

Chile, 2022

Selected in the top 2% of most cited scientists by a study performed by Elsevier and Stanford:
WSIS Prize 2022 Champion

WSIS Prize 2022 Champion

Chile, 2022

The project was among the top five most voted in your category.
Highly Cited Scientist

Clarivate (Web of Science)

Chile, 2022

Awarded by Clarivate (Web of Science) as a “Highly Cited Scientist”, among the TOP 1% most cited scientist in the world.


Immunohistochemical characterisation of the adult Nothobranchius furzeri intestine Borgonovo, Janina Article ISI CELL AND TISSUE RESEARCH (2024)
IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts Li, Chao; Li, Shiqian; Zhang, Guangyu; Li, Qinfeng; Song, Weidan; Wang, Xiaoding; Cook, Jane A.; van der Stoel, Miesje; Wright, Bradley W.; Altamirano, Francisco; et al. Article ISI CIRCULATION (2024)
c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration Martinez, Alexis; Llambi, Fabien; Fitzgerald, Patrick; Guy, Cliff; Kaminski, Marcin M.; Van Zundert, Brigitte; Marugan, Juan J. Article ISI ANTIOXIDANTS (2023)
The ER stress sensor IRE1 interacts with STIM1 to promote store-operated calcium entry, T cell activation, and muscular differentiation Laubry, Loann; Brunetti, Jessica; Koenig, Stephane; Wang, Xiaoxia; Castelbou, Cyril; Liu, Yong; Frieden, Maud; Demaurex, Nicolas Article ISI Cell Reports (2023)
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis Poblete, Natalia; Li Diaz-Hung, Mei; Sabusap, Carleen Mae P.; Gerakis, Yannis; Fuentealba, Matias; Quiroz, Gabriel; Sardi, Pablo; V. Lourenco, Mychael; Ribeiro, Felipe C.; Ferreira, Sergio T.; et al. Article ISI MOLECULAR THERAPY (2023)
ER-mitochondrial contact sites: Balancing energy and protein homeostasis Article (2022)
Mutant PDIA3 causes neurodevelopmental impairment by disturbing endoplasmic reticulum proteostasis. Article EMBO JOURNAL (2022)
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis Medinas, Danilo Bilches; Malik, Sajid; Yildiz-Bolukbasi, Esra; Borgonovo, Janina; Saaranen, Mirva J.; Pulgar, Eduardo; Contreras, Darwin; Bodaleo, Felipe; Quiroz, Gabriel; Rozas, Pablo; et al. Article ISI EMBO JOURNAL (2022)
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging Hung, Mei-Li Diaz; Vidal, Rene; Fuentealba, Matias; Miedema, Tim; Sabusap, Carleen M.; Adamson, Stuart; Vitangcol, Kaitlyn; Zhang, Xu; Nakamura, Tomohiro; Sardi, Sergio Pablo; et al. Article ISI EMBO JOURNAL (2022)
Adapting the proteostasis capacity to sustain brain healthspan Article Cell (2021)
DEF8 and Autophagy-Associated Genes are Altered in Mild Cognitive Impairment, Probable Alzheimer’s Disease Patients and a Transgenic Model of the Disease Article Journal of Alzheimer's Disease (2021)
Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases Bi, Yaguang; Sowers, James R. Article Nature Reviews Cardiology (2021)
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration Castillo, Valentina; Cisternas, Marisol; Leal, Sirley; Martinez, Alexis; Grandjean, Julia; Sonia, Donzelli; Lashuel, Hilal A.; Matus, Soledad Article Molecular Therapy (2021)
Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS Rozas, Pablo; Pinto, Cristina; Traub, Francisca Martinez; Ojeda, Jorge; Wright, Madison T. Article ISI ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)
Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease Gomez, Barbara; Mery, Elena Article ISI SCOPUS Frontiers in Cellular Neuroscience (2020)
Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response Ortiz, Rina; Orellana, Pamela Contreras Article CELL DEATH & DISEASE (2020)
Genotoxic stress triggers the activation of IRE1 alpha-dependent RNA decay to modulate the DNA damage response Dufey, Estefanie; Pihan, Philippe; Campos, Gisela; Godoy, Patricio; Walter, Peter Article ISI NATURE COMMUNICATIONS (2020)
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease De Smedt J.; Widera A.; Ghallab A.; PÃ¼tter L.; Edlund K.; Cadenas C.; Marchan R.; Guthke R.; Verfaillie C.; Sachinidis A.; et al. Article ISI SCOPUS ARCHIVES OF TOXICOLOGY (2020)
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates Wu, Di; Thiruvalluvan, Arun; Plate, Lars; Thielen, Peter; Longo, Kenneth A.; Geddes, Brad J.; Lederkremer, Gerardo Z.; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; et al. Article ISI ACTA NEUROPATHOLOGICA (2020)
Mastering organismal aging through the endoplasmic reticulum proteostasis network Taylor, Rebecca C. Article ISI AGING CELL (2020)
Mechanisms, regulation and functions of the unfolded protein response Zhang, Kezhong Article ISI NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease Salvadores, Natalia; Saquel, Cristian; Martinez, Alexis; Gamez, Nazaret; Soto, Paulina; Soto, Claudio.; Court, Felipe A. Article ISI SCOPUS CELL DEATH AND DIFFERENTIATION (2020)
The UPRosome-decoding novel biological outputs of IRE1 alpha function Pihan, Philippe Article ISI JOURNAL OF CELL SCIENCE (2020)
When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response Blondel, Alice Article ISI TRENDS IN CELL BIOLOGY (2020)
beta-catenin aggregation in models of ALS motor neurons: GSK3 beta inhibition effect and neuronal differentiation MartÃnez A.D.; HenrÃquez J.P. Article ISI SCOPUS NEUROBIOLOGY OF DISEASE (2019)
Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion Sauzay C. Article ISI SCOPUS CANCERS (2019)
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis Beltran, S; Vicencio E.; Arcos J.; Labrador L.; Cortes B.I.; Bergmann C.A.; Hernandez M.F.; Matamala, J. M.; Bargsted L.; Manque P.A. Article ISI SCOPUS MOLECULAR NEURODEGENERATION (2019)
Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics Durand, Sylvere; Mortenson, David E.; Hazari, Younis; Sassano, Maria L.; Pihan, Philippe; van Vliet, Alexander R.; Gonzalez-Quiroz, Matias; Kerkhofs, Martijn; Kaufman, Randal J.; Luke Wiseman, R.; et al. Article ISI SCOPUS Nature Cell Biology (2019)
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability Perez, Viviana; Zelada, Diego; Court, Felipe A.; Angel Perez, Miguel; Fuenzalida, Marco; Abrigo, Johanna; Moya-Alvarado, Guillermo; Carlos Tapia, Juan; Bronfman, Francisca C.; Pablo Henriquez, Juan Article ISI SCOPUS ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis Rozas, Pablo; Woehlbier, Ute*; Bosco, Daryl A. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1 alpha Lebeaupin, C; Hazari, Y; Vasseur-Cognet, M; Ali, MMU; Bailly-Maitre, B Article ISI SCOPUS MOLECULAR CELL (2018)
IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A Villarroel-Campos, David; Pulgar, Eduardo; Figueroa, Ricardo; Rodriguez, Diego A.; Court, Felipe A.; Couve, Andres; Glavic, Alvaro. Article ISI SCOPUS Nature Cell Biology (2018)
Unraveling the role of motoneuron autophagy in ALS Valenzuela, Vicente; Nassif, Melissa;; Hetz, Claudio Article ISI SCOPUS AUTOPHAGY (2018)
IRE1 signaling exacerbates Alzheimer's disease pathogenesis Cornejo, Victor Hugo; Espinoza, Sandra; Foley, Andrew; Gajardo, Ivana; Iwawaki, Takao; Scheper, Wiep Article ISI SCOPUS ACTA NEUROPATHOLOGICA (2017)
Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury Onate, M; Catenaccio, A; Martinez, G; Armentano D.; Parsons, G; Kerr, B.; Hetz C. ; Court, FA Article ISI SCOPUS SCIENTIFIC REPORTS (2016)
ALS-linked protein disulfide isomerase variants cause motor dysfunction Woehlbier, U; Colombo, A; Pérez V; Ojeda J.; Andreu C.I.; Torres M.; Valenzuela, V.; Rozas P.; Vidal R.L.; Salameh J.; et al. Article ISI SCOPUS EMBO JOURNAL (2016)
Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport Mardones P.; Rubinsztein D.C.; Hetz C. Article ISI SCOPUS SCIENCE SIGNALING (2016)
NF kappa B is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation Nivon M.; Fort L.; Muller P.; Richet E.; Simon, S.; Guey B.; Fournier M.; Arrigo A.-P.; Hetz C. ; Atkin J.D. Article ISI SCOPUS MOLECULAR BIOLOGY OF THE CELL (2016)
Regulation of Memory Formation by the Transcription Factor XBP1 Martinez, G; Mardones P.; Serrano, FG; Ardiles AO; Wirth C.; Valdés P.; Thielen P; Schneider, BL; Kerr, B.; Valdes, JL; et al. Article ISI SCOPUS Cell Reports (2016)
ER proteostasis disturbances in Parkinson's disease: novel insights Mercado, G; Castillo V.; Vidal, R; Hetz C. Article ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2015)
ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders Torres M.; Matamala, JM; Duran-Aniotz, C; Cornejo, VH; Foley A; Hetz C. Article ISI SCOPUS Virus Research (2015)
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration Castillo, Valentina; Oate, Maritza; Woehlbier, Ute*; Rozas, Pablo; Andreu, Catherine; Medinas, Danilo; Valds, Pamela; Osorio, Fabiola; Mercado, Gabriela; Kerr, Bredford; et al. Article ISI SCOPUS PLOS ONE (2015)
Gene therapy in Parkinson's disease: targeting the endplasmic reticulum proteostasis network Castillo V.; Mercado, G; Hetz C. Article ISI SCOPUS Neural Regeneration Research (2015)
Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients Gonzalez-Perez, P; Woehlbier, U; Chian, RJ; Sapp, P; Rouleau, GA; Leblond, CS; Daoud, H; Dion, PA; Landers, JE; Hetz C. ; et al. Article ISI SCOPUS Gene (2015)
PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response Gupta A.; Hossain, MM; Read, DE; Hetz C. ; Samali, A; Gupta, S Article ISI SCOPUS SCIENTIFIC REPORTS (2015)
The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein Torres M.; Medinas DB; Matamala, JM; Woehlbier, U; Cornejo, VH; Solda T.; Andreu, C; Rozas P.; Matus, S; Muñoz, N.; et al. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
A new method to measure autophagy flux in the nervous system Matus, S; Valenzuela, V.; Hetz C. Article ISI SCOPUS AUTOPHAGY (2014)
Autophagy meets fused in sarcoma-positive stress granules Matus, Soledad; Bosco, Daryl A.; Hetz, Claudio Article ISI SCOPUS NEUROBIOLOGY OF AGING (2014)
Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview Dufey E.; Sepulveda D.; Rojas-Rivera, D; Hetz C. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1 Valdés P.; Mercado, G; Molina C.; Parsons, G; Court, FA; Martínez, A.; Galleguillos D; Armentano D.; Schneider, BL; Hetz C. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis Groenendyk J.; Peng, ZL; Dudek, E; Fan X.; Mizianty, MJ; Dufey E.; Urra, H; Sepulveda D.; Rojas-Rivera, D; Lim, Y; et al. Article ISI SCOPUS SCIENCE SIGNALING (2014)
Modeling UPR adaptive responses: Understanding the mechanisms that determine cell fate under endoplasmic reticulum (ER) stress had been hampered by the lack of models to study unfolded protein response (UPR) adaptive phases. The development of an engineered protein to conditionally induce its misfolding allowed the establishment of a resolvable ER stress condition Hetz C. Article SCOPUS Nature Chemical Biology (2014)
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis Nassif, M; Valenzuela, V.; Rojas-Rivera, D; Vidal, R; Matus, S; Castillo, K; Fuentealba Y.; Kroemer G.; Levine, B; Hetz C. Article ISI SCOPUS AUTOPHAGY (2014)
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity Campos, Gisela; Schmidt-Heck, Wolfgang; Ghallab, Ahmed; Rochlitz, Katherine; Putter, Larissa; Medinas, Danilo; Hetz, Claudio; Widera, Agata; Cadenas, Cristina; Begher-Tibbe, Brigitte; et al. Article ISI SCOPUS ARCHIVES OF TOXICOLOGY (2014)
A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice Acuna, AI; Esparza M.; Kramm C.; Beltran, FA; Parra, AV; Cepeda, C; Toro, CA; Hetz C. ; Brauchi, S.; Levine, MS Article ISI SCOPUS NATURE COMMUNICATIONS (2013)
Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis Kiviluoto S; Luyten T; Schneider L; Lisak D; Rojas-Rivera, D; Welkenhuyzen K; Missaen, L; De Smedt H; Parys, JB; Hetz C. ; et al. Article ISI SCOPUS Cell Calcium (2013)
Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis Matus, S; López E.; Valenzuela, V.; Nassif, M; Hetz C. Article ISI SCOPUS PLOS ONE (2013)
Herp depletion protects from protein aggregation by up-regulating autophagy Quiroga, C; Gatica, D; Paredes, F; Bravo, R.; Troncoso R.; pedrozo, Z; Rodríguez, AE; Toro, B; Chiong M.; Hetz C. ; et al. Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Cell Research (2013)
Measurement of autophagy flux in the nervous system in vivo Castillo, K; Valenzuela, V.; Matus, S; Nassif, M; Onate, M; Fuentealba Y.; Encina G.; Irrazabal T.; Parsons, G; Court, FA; et al. Article ISI SCOPUS Cell Death and Disease (2013)
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons Castillo, K; Nassif, M; Valenzuela, V.; Rojas F.; Matus, S; Mercado, G; Court, FA; van Zundert, B; Hetz C. Article ISI SCOPUS Autophagy (2013)
A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway Zamorano S.; Rojas-Rivera, D; Lisbona, F; Parra, V; Court, F. A.; Villegas, R; Lavandero S.; Hetz C. Article ISI SCOPUS PLOS ONE (2012)
Activation of the unfolded protein response enhances motor recovery after spinal cord injury Valenzuela, V.; Collyer, E.; Armentano D.; Court, F. A.; Hetz C. Article ISI SCOPUS Cell Death and Disease (2012)
Altered Prion Protein Expression Pattern in CSF as a Biomarker for Creutzfeldt-Jakob Disease Torres M.; Cartier, L; Matamala, J. M.; Hernández N.; Woehlbier, U; Hetz C. Article ISI SCOPUS PLOS ONE (2012)
Astrocytic alpha(V)beta(3) Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1 Herrera-Molina, R; Frischknecht R.; Maldonado, H.; Hetz C. ; de la Luz Aylwin M.; Schneider, P.; Leyton, L. Article ISI SCOPUS PLOS ONE (2012)
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1 alpha Rodriguez D.A.; Zamorano S.; Lisbona, F; Rojas-Rivera, D; Urra, H; Armisen, R; Henriquez D.R.; H Cheng E.; Letek M.; Vaisar T.; et al. Article ISI SCOPUS EMBO JOURNAL (2012)
MV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease Zuleta A.; Vidal R.L.; Armentano D.; Parsons, G; Hetz C. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2012)
Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis Gupta, S; Read, DE; Deepti, A; Cawley, K; Gupta A.; Oommen, D; Verfaillie, T; Matus, S; Smith, MA; Mott, JL; et al. Article ISI SCOPUS Cell Death and Disease (2012)
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy Vidal R.L.; Figueroa, A; Court, F. A.; Thielen P; Molina C.; Wirth C.; Caballero, B; Kiffin, R; Segura-Aguilar, J; Hetz C. Article ISI SCOPUS Human Molecular Genetics (2012)
TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis Rojas-Rivera, D; Armisen, R; Colombo, A; Martinez, G; Eguiguren, A. L.; Diaz A.; Kiviluoto S; Rodriguez D.; Patron, M; Rizzuto, R; et al. Article ISI SCOPUS CELL DEATH AND DIFFERENTIATION (2012)
Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF Paula-Lima, AC; Adasme, T.; SanMartin, C.; Sebollela A.; Hetz C. ; Hidalgo C. Article ISI SCOPUS Antioxidants and Redox Signaling (2011)
Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore Barrientos S.A.; Martinez, N.W.; Alvarez J.; Court, F. A.; Yoo S.; Zamorano S.; Hetz C. ; Twiss J.L. Article ISI SCOPUS Journal of Neuroscience (2011)
BAX inhibitor-1 regulates autophagy by controlling the IRE1 alpha branch of the unfolded protein response Castillo, K; Rojas-Rivera, D; Lisbona, F; Caballero, B; Nassif, M; Court, FA; Schuck, S; Ibar C.; Walter, P.; Sierralta, J; et al. Article ISI SCOPUS EMBO JOURNAL (2011)
Lack of Activation of the Unfolded Protein Response in Mouse and Cellular Models of Niemann-Pick Type C Disease Klein, A.; Mosqueira, M; Martinez, G; Robledo, F; GONZALEZ, M; Caballero, B; Cancino, GI; Alvarez, AR; Hetz C. ; Zanlungo S. Article ISI SCOPUS NEURODEGENERATIVE DISEASES (2011)
Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons Klein, A.; Maldonado, C; GONZALEZ, M; Robledo, F; de Arce KP; Hetz C. ; Alvarez, AR; Zanlungo S. Article ISI SCOPUS NEUROBIOLOGY OF DISEASE (2011)
Protein folding stress in neurodegenerative diseases: a glimpse into the ER Matus, S; Glimcher, LH; Hetz C. Article ISI SCOPUS Current Opinion in Cell Biology (2011)
Alternative Functions of the BCL-2 Protein Family at the Endoplasmic Reticulum Rojas-Rivera, D; Caballero, B; Zamorano S.; Lisbona, F; Hetz C. Article ISI SCOPUS CANNABINOIDS AND SLEEP: MOLECULAR, FUNCTIONAL AND CLINICAL ASPECTS (2010)
Amyotrophic Lateral Sclerosis Pathogenesis: A Journey Through the Secretory Pathway Nassif, M; Matus, S; Castillo, K; Hetz C. Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2010)
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1 alpha-XBP1 Signaling through a Physical Interaction Gupta, S; Deepti, A; Deegan, S; Lisbona, F; Hetz C. ; Samali, A Article ISI SCOPUS PLOS BIOLOGY (2010)
Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress Torres M.; Castillo, K; Armisen, R; Stutzin A.; Soto C.; Hetz C. Article ISI SCOPUS PLOS ONE (2010)
BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1 alpha Lisbona, F; Rojas-Rivera, D; Thielen P; Zamorano S.; Todd, D; Martinon, F; Glavic A.; Kress, C; Lin, JH; Walter, P.; et al. Article ISI SCOPUS MOLECULAR CELL (2009)
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy Hetz C. ; Thielen P; Matus, S; Nassif, M; Court, F; Kiffin, R; Martinez, G; Cuervo, AM; Brown, RH; Glimcher, LH Article ISI SCOPUS GENES DEVELOPMENT (2009)
XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy Hetz C. ; Thielen P; Matus, S; Nassif, M; Court, F; Kiffin, R; Martinez, G; Cuervo, AM; Brown, RH; Glimcher, LH Article ISI SCOPUS AUTOPHAGY (2009)
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis Hetz C. ; Lee, AH; Gonzalez-Romero, D; Thielen P; Castilla J.; Soto C.; Glimcher, LH Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Perturbation of endoplasmic reticulum homeostasis facilitates prion replication Hetz C. ; Castilla J.; Soto C. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Prion Pathogenesis is Independent of Caspase-12 Steele, AD; Hetz C. ; Yi, CH; Jackson, WS; Borkowski, AW; Yuan, JY; Wollmann, RH; Lindquist, S Article ISI PRION (2007)
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia Hetz C. ; Vitte, PA; Bombrun A.; Rostovtseva, TK; Montessuit, S; Hiver, A; Schwarz, MK; Church, DJ; Korsmeyer, SJ; Martinou, JC; et al. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
In vitro generation of infectious scrapie prions Castilla J.; Saa, P; Hetz C. ; Soto C. Article ISI SCOPUS CELL (2005)
The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity Hetz C. ; Russelakis-Carneiro, M; Walchli, S; Carboni, S; Vial-Knecht, E; Maundrell, K; Castilla J.; Soto C. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2005)
Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts Russelakis-Carneiro, M; Hetz C. ; Maundrell, K; Soto C. Article ISI SCOPUS AMERICAN JOURNAL OF PATHOLOGY (2004)
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein Hetz C. ; Russelakis-Carneiro, M; Maundrell, K; Castilla J.; Soto C. Article ISI SCOPUS EMBO JOURNAL (2003)
Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines Hetz C. ; Barros, LF; Lagos R. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Nonselective cation channels as effecters of free radical-induced rat liver cell necrosis Barros, LF; Stutzin A.; Calixto, A; Catalán M.; Castro, J.; Hetz C. ; Hermosilla T. Article ISI SCOPUS HEPATOLOGY (2001)
Structure, organization and characterization of the gene cluster involved in the production of microcin E492, a channel-forming bacteriocin Lagos R.; Baeza, M.; Corsini, G; Hetz C. ; Strahsburger, E; Castillo, JA; Vergara C.; Monsterio, O Article ISI SCOPUS MOLECULAR MICROBIOLOGY (2001)
Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1 Borgonovo, J.; Nunes-Hasler P; Kepp, O; Saarnio S; Sagredo A Article


Regulation of the endolysosomal pathway by beclin-1 and its role in the proteolytic processing of the amyloid precursor protein González A; Cornejo, V; Hetz C. ; Mardones, G; Burgos P. Abstract ISI JOURNAL OF NEUROCHEMISTRY (2015)
Bci is a new component of the autophagy pathway Nassif, M; Vicencio E.; Gherardelli C.; Matamala, JM; Arias, R.; Rojas M.; Maracaja, V; Hetz C. ; Woehlbier, U Abstract ISI FEBS JOURNAL (2014)
Depletion of Beclin-1 increases the delivery of cathepsin D and EGF receptor to lysosomes. González A; Cornejo, V; Hetz C. ; Mardones, G; Burgos P. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
Endoplasmic reticulum stress responses to disrupted endoplasmic reticulum ca2+homeostasis Groenendyk J.; Hetz C. ; Kurgan L.; Michalak M. Abstract ISI CARDIOVASCULAR RESEARCH (2014)
Functional study of the IRE1 interactome: fine tunning of UPR signaling Rojas-Rivera, D; Rodriguez D.; Sepulveda D.; Sierralta, J; Hetz C. Abstract ISI FEBS JOURNAL (2014)
Protein disulfide isomerase gene variants are associated with amyotrophic lateral sclerosis Woehlbier, U; Gonzalez-Perez, P; Colombo, A; Saaranen MJ.,; Bustos F.; Lopez-Gonzalez, R; Ojeda J.; Pérez V; Valenzuela, V.; Medinas D; et al. Abstract ISI FEBS JOURNAL (2014)
Depletion of Beclin-1 reduces the levels of carboxy terminal fragment beta of the amyloid precursor protein by a mechanism dependent on autophagosome function González A; Cornejo, V; Hetz C. ; Mardones, G; Burgos, PV Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2013)
Monocarboxylate are not important to support synaptic activity in Huntington's disease Solis, MB; Beltran, FA; Acuna, AI; Parra, A.; Hetz C. ; Levine, MS Abstract ISI JOURNAL OF NEUROCHEMISTRY (2013)
Perk-dependent repression of miR-106b-25 cluster is required for ER stress induced apoptosis Read, DE; Agostinis P.; Hetz C. ; Mott, JL; Samali, A; Gupta, S Abstract ISI IRISH JOURNAL OF MEDICAL SCIENCE (2013)
Traffic of ascorbic acid transporter SVCT2 is impaired in Huntington's disease Acuna, AI; Esparza M.; Kramm C.; Toro, C.; Vidal, R; Hetz C. ; Brauchi, S. Abstract ISI JOURNAL OF NEUROCHEMISTRY (2013)
Protein folding stress in neurodegenerative disease: an interplay between ER stress and autophagy Hetz C. Abstract ISI FEBS JOURNAL (2012)
Correlation of lactate dehydrogenase activity and 14-3-3 protein in cerebrospinal fluid from patients with Creutzfeldt-Jakob disease Torres M.; Matamala, JM; Hernández N.; Hetz C. ; Cartier, L Abstract ISI EUROPEAN JOURNAL OF NEUROLOGY (2010)
Caspase-dependent necrosis-like cell death downstream of the Fas receptor is associated with lipid scrambling and delayed ceramide increase in lymphoid cells Hetz C. ; Torres V.; Leyton, L. Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2002)


Assays to Study IRE1 Activation and Signaling BookSection (2022)


Emerging roles of the unfolded protein response (UPR) in the nervous system: A link with adaptive behavior to environmental stress? BookWhole ISI SCOPUS International Review of Cell and Molecular Biology (2020)
Dual role of autophagy in neurodegenerative diseases: The case of amyotrophic lateral sclerosis Bargsted L.; Vidal R.L.; Hetz C. ; Matus, S BookWhole SCOPUS Toxicity and Autophagy in Neurodegenerative Disorders (2015)
When the Good Turns Bad: Challenges in the Targeting of Autophagy in Neurodegenerative Diseases Nassif, M; Medinas D; Castillo, K; Gherardelli C.; Hetz C. BookWhole SCOPUS Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (2014)
Protein misfolding disorders: A trip into the ER Hetz C. BookWhole SCOPUS Protein Misfolding Disorders: A Trip into the ER (2009)
Targeting endoplasmic reticulum stress pathways to treat neurological disorders associated with protein misfolding Galleguillos D; Matus, S; Valenzuela, V.; Valdés P.; Martínez, A.; Nassif, M; Torres M.; Martinez, G; Hetz C. BookWhole SCOPUS Protein Misfolding Disorders: A Trip into the ER (2009)


Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob: Caso clínico Marcos Ramírez; Aarón Vidal; Sebastián Cornejo; Darío Ramírez; Danilo Medinas; Gonzalo Bustamante; Renzo Pasquali; Claudio Hetz CaseReport ISI SCIELO SCOPUS REVISTA MEDICA DE CHILE (2016)


Meet our associate editor Hetz, C.A. Editorial SCOPUS Current Molecular Medicine (2015)
BCL-2 protein family. Essential regulators of cell death. Preface. Hetz C. Editorial SCOPUS CANNABINOIDS AND SLEEP: MOLECULAR, FUNCTIONAL AND CLINICAL ASPECTS (2010)
Preface Hetz C. Editorial SCOPUS Protein Misfolding Disorders: A Trip into the ER (2009)


ER stress links aging to sporadic ALS Medinas DB EditorialMaterial ISI SCOPUS AGING-US (2019)
Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease Duran-Aniotz, C; Cornejo, VH; Hetz C. EditorialMaterial ISI SCOPUS BRAIN (2016)
Peroxisomes Get Loud: A Redox Antidote to Hearing Loss Mardones P.; Hetz C. EditorialMaterial ISI SCOPUS Cell (2015)
RNA metabolism: putting the brake on the UPR Carreras-Sureda, A; Hetz C. EditorialMaterial ISI SCOPUS EMBO Reports (2015)
Stressing out the ER in aminoglycoside-induced hearing loss Garcia-Huerta, P; Rivas, A; Hetz C. EditorialMaterial ISI SCOPUS Cell Death and Disease (2015)
Theme Series - UPR in cancer Hetz C. ; Chevet, E EditorialMaterial ISI SCOPUS Seminars in Cancer Biology (2015)
A Novel ER Stress-Independent Function of the UPR in Angiogenesis Urra, H; Hetz C. EditorialMaterial ISI SCOPUS MOLECULAR CELL (2014)
Cell-Nonautonomous Control of the UPR: Mastering Energy Homeostasis Mardones P.; Dillin A; Hetz C. EditorialMaterial ISI SCOPUS CELL METABOLISM (2014)
Common Ground: Stem Cell Approaches Find Shared Pathways Underlying ALS Matus, S; Medinas DB; Hetz C. EditorialMaterial ISI SCOPUS CELL STEM CELL (2014)
Memory loss in Alzheimer's disease: are the alterations in the UPR network involved in the cognitive impairment? Duran-Aniotz, C; Martinez, G; Hetz C. EditorialMaterial ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2014)
RESETing ER proteostasis: selective stress pathway hidden in the secretory route couve, a; Hetz C. EditorialMaterial ISI SCOPUS EMBO JOURNAL (2014)
Proteostasis Impairment: At the Intersection between Alzheimer's Disease and Diabetes Medinas DB; Hetz C. EditorialMaterial ISI SCOPUS CELL METABOLISM (2013)
Signaling in Cell Death, Survival, Proliferation and Degeneration Smaili, SS; Quest, AFG; Hetz C. ; Lavandero S. EditorialMaterial ISI CURRENT MOLECULAR MEDICINE (2013)
THE BIOLOGICAL MEANING OF THE UPR Hetz C. EditorialMaterial ISI SCOPUS Nature Reviews Molecular Cell Biology (2013)
Unspliced XBP1 controls autophagy through FoxO1 Hetz C. EditorialMaterial ISI SCOPUS Cell Research (2013)
Autophagy impairment: a crossroad between neurodegeneration and tauopathies Nassif, M; Hetz C. EditorialMaterial ISI SCOPUS BMC Biology (2012)
Cell-nonautonomous control of the UPR Martinez, G; Hetz C. EditorialMaterial ISI SCOPUS EMBO REPORTS (2012)
Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease Vidal R.L.; Hetz C. EditorialMaterial ISI SCOPUS Autophagy (2012)
Hormesis Protecting neurons against cellular stress in Parkinson disease Matus, S; Castillo, K; Hetz C. EditorialMaterial ISI SCOPUS Autophagy (2012)
The ER in 4D: a novel stress pathway controlling endoplasmic reticulum membrane remodeling Urra, H; Hetz C. EditorialMaterial ISI SCOPUS Cell Death and Differentiation (2012)
Protein homeostasis networks in physiology and disease Hetz C. ; Glimcher, LH EditorialMaterial ISI SCOPUS Current Opinion in Cell Biology (2011)
Targeting autophagy in ALS A complex mission Nassif, M; Hetz C. EditorialMaterial ISI SCOPUS Autophagy (2011)
The UPR as a survival factor of cancer cells: More than folding proteins? Hetz C. EditorialMaterial ISI SCOPUS Leukemia Research (2009)
Turning off the unfolded protein response An interplay between the apoptosis machinery and ER stress signaling Lisbona, F; Hetz C. EditorialMaterial ISI CELL CYCLE (2009)
Apoptosis, necrosis and autophagy: From mechanisms to biomedical applications Hetz C. EditorialMaterial ISI CURRENT MOLECULAR MEDICINE (2008)
Identification by transcription profiling in human colon carcinoma cells of genes regulated by tumor suppressor Caveolin-1 Hetz C. ; Monardes, V.; Lisboa, P.; Munroe D.; Leyton, L.; Quest, AFG EditorialMaterial ISI BIOMETALS (2003)


Saved by the Matrix: UPR Independent Survival under ER Stress Koopman M.; Nollen E.A.A. Generic ISI SCOPUS CELL (2019)


The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis Hetz C. ; Thielen P; Fisher J.; Pasinelli, P; Brown, RH; Korsmeyer, S; Glimcher, L Letter ISI CELL DEATH AND DIFFERENTIATION (2007)


PROTEIN HOMEOSTASIS Modeling UPR adaptive responses Medinas, Danilo B.; Hetz, Claudio NewsItem ISI NATURE CHEMICAL BIOLOGY (2014)


ERp57 as a novel cellular factor controlling prion protein biosynthesis: Therapeutic potential of protein disulfide isomerases Sepúlveda M.; Rozas P.; Hetz C. Note ISI SCOPUS PRION (2016)
ERp57 in neurodegeneration and regeneration Bargsted L.; Hetz C. ; Matus, S Note ISI SCOPUS NEURAL REGENERATION RESEARCH (2016)


Defining thesignificance of the Unfolded Protein Response (UPR) as a therapeutic target to treat liver fibrosis Claudio Hetz Proyecto (2024)
Dissecting the cell-type specific contribution of the UPR to the synucleinopathy in Parkinson’s disease Proyecto (2023)
Geroscience Center for Brain Health and Metabolism Claudio Hetz Proyecto (2022)
Improving proteostasis to reduce the adverse effects of stress in the elderly. Claudio Hetz Proyecto (2022)
Protective role of MyDGF against ER stress. Proyecto (2022)
Research proposal to BioSynaptica: ALS preclinical study to evaluate therapeutic effects of an engineered form of recombinant human erythropoietin at the Biomedical Neuroscience Proyecto (2022)
Role of the unfolded protein response (UPR) in the progression of brain cancer.   Claudio Hetz Proyecto (2022)
Terapia génica para tratar la esclerosis lateral amiotrófica (ELA) mediante una mejora proteostática Claudio Hetz Proyecto (2022)
Coping with environmental stress: at the interphase between neuronal proteostasis and brain physiology Proyecto (2021)
Uncovering the Contribution of Cell-Type-Specific ER Proteostasis Networks to PD Pathogenesis Proyecto (2021)
Defining the role of ER stress signaling in C9orf7-mediated ALS.   Claudio Hetz Proyecto (2020)
Prueba de concepto preclínica: Una terapia génica para tratar ELA-DFT Proyecto (2020)
UPRplus: A novel gene therapy to treat Parkinson´s disease Claudio Hetz Proyecto (2020)
Gene therapy to restore ER proteostasis imbalance in Parkinson disease Proyecto (2019)
Proteostaser-1: a gene therapy to reduce neurodegeneration and improve cognitive function in Alzheimers disease Claudio Hetz Proyecto (2019)
ER stress in post-traumatic distress order Proyecto (2018)
Novel Roles of the unfolded protein response (UPR) in cancer Claudio Hetz Proyecto (2018)
Disrupted proteostasis as a shared mechanism of cognitive decline in normal aging and Alzheimer´s disease Proyecto (2017)
Interfere to Suppress or Promote IRE1 (INSPIRED) RISE Program Proyecto (2016)
Neuromorphic Inspired Science to Maximize Big Data Dynamic Problem Solving for Future intelligence, Surveillance, and Reconnaissance Operations. Proyecto (2016)
Targeting the endoplasmic reticulum (ER) stress sensor IRE1 to treat SOD1-mediated ALS Proyecto (2016)
A novel function of the Unfolded Protein Response (UPR) in learning and memory Proyecto (2015)
Role of IRE1 interactome in cell migration and cancer. Proyecto (2014)
The UPRosome: novel regulatory checkpoints and physiological outputs. Proyecto (2014)
GENE THERAPY STRATEGY TO TARGET THE UNFOLDED PROTEIN RESPONSE IN ALS. Proyecto (2013)
A role of ER stress in wild-type SOD1 misfolding: A model for sALS Proyecto (2012)
Cellomics: An automatized platform for high throughput microscopy with biotechnological potential. Proyecto (2012)
Defining the function of protein Disulfide Isomerases in ALS Proyecto (2012)
Targeting the unfolded protein response (UPR) transcription factor XBP1 to alleviate neurodegeneration triggered by alpha-synuclein Proyecto (2012)
UPRplus: A novel gene therapy to treat Parkinson´s disease. Proyecto (2012)
Biomedical Neuroscience Institute (BNI). Claudio Hetz Proyecto (2011)
Defining the contribution of the disulfide isomerase ERp57 to the pathogenesis of Prion-related disorders Proyecto (2010)
Millennium Nucleus for Neural Morphogenesis (NEMO). Proyecto (2009)
Role of the Unfolded Protein Response (UPR) in tumor suppression by caveolin-1. Proyecto (2009)
The tumor suppressor activity of Caveolin 1 is associated with an inhibition of the UPR Proyecto (2009)
A role of the UPR in Parkinson's disease Proyecto (2008)
Regulation of neuronal apoptosis by Abl in Alzheimer's disease. Proyecto (2008)
Targeting Autophagy for the removal of mutant SOD1 in ALS. Proyecto (2008)
Targeting Autophagy for the treatment of Protein Conformational Disorders affecting the nervous system. Proyecto (2008)
Center for Molecular Studies of the Cell (CEMC) Proyecto (2007)


Autophagy in hepatic adaptation to stress Review ISI SCOPUS JOURNAL OF HEPATOLOGY (2020)
Pharmacological targeting of the unfolded protein response for disease intervention Review ISI SCOPUS NATURE CHEMICAL BIOLOGY (2019)
Small Molecules to Improve ER Proteostasis in Disease Albert-Gasco H.; Auyeung V.C.; Mallucci G.R. Review ISI SCOPUS TRENDS IN PHARMACOLOGICAL SCIENCES (2019)
Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease Review ISI SCOPUS BIOLOGY OF THE CELL (2019)
The UFMylation System in Proteostasis and Beyond Review ISI SCOPUS TRENDS IN CELL BIOLOGY (2019)
ER stress and the unfolded protein response in neurodegeneration Review ISI SCOPUS NATURE REVIEWS NEUROLOGY (2017)
Endoplasmic Reticulum Stress and the Hallmarks of Cancer Urra, H; Dufey E.; Avril, T; Chevet, E; Hetz C. Review SCOPUS Trends in Cancer (2016)
Control of systemic proteostasis by the nervous system Mardones, Pablo; Martínez, Gabriela; Hetz, Claudio Review ISI SCOPUS Trends in Cell Biology (2015)
ER proteostasis addiction in cancer biology: Novel concepts Dufey E.; Urra, H; Hetz C. Review ISI SCOPUS Seminars in Cancer Biology (2015)
Proteostasis control by the unfolded protein response Hetz C. ; Chevet, E Review ISI SCOPUS Nature Cell Biology (2015)
Targeting the unfolded protein response for disease intervention Rivas, A; Hetz C. Review ISI SCOPUS Expert Opinion on Therapeutic Targets (2015)
TMBIM protein family: ancestral regulators of cell death Rojas-Rivera, D; Hetz C. Review ISI ONCOGENE (2015)
Addicted to secrete - novel concepts and targets in cancer therapy Dejeans N.; Manie, S; Hetz C. ; Bard, F; Hupp, T; Agostinis P.; Samali, A; Chevet, E Review ISI SCOPUS TRENDS IN MOLECULAR MEDICINE (2014)
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases Hetz C. ; Mollereau, B Review ISI SCOPUS NATURE REVIEWS NEUROSCIENCE (2014)
Targeting autophagy in neurodegenerative diseases Vidal, René L.; Matus, Soledad; Bargsted, Leslie; Hetz, Claudio Review ISI SCOPUS TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
An ERcentric view of Parkinson's disease Mercado, G; Valdés P.; Hetz C. Review ISI SCOPUS Trends in Molecular Medicine (2013)
ER dysfunction and protein folding stress in ALS Matus, S; Valenzuela, V.; Hetz C. Review SCOPUS International Journal of Cell Biology (2013)
Role of the Unfolded Protein Response in Organ Physiology: Lessons from Mouse Models Cornejo, VH; Pihan, P; Hetz C. Review ISI SCOPUS IUBMB Life (2013)
Targeting the unfolded protein response in disease Hetz C. ; Chevet, E; Harding, HP Review ISI SCOPUS Nature Reviews Drug Discovery (2013)
The unfolded protein response in Alzheimer's disease Cornejo, VH; Hetz C. Review ISI SCOPUS Seminars in Immunopathology (2013)
When ER stress reaches a dead end Urra, H; Dufey E.; Lisbona, F; Rojas-Rivera, D; Hetz C. Review ISI SCOPUS Biochimica et Biophysica Acta - Molecular Cell Research (2013)
Guidelines for the use and interpretation of assays for monitoring autophagy Abdalla, FC; Abeliovich, H; Abraham, RT; Acevedo-Arozena, A; ADELI, K.; Agholme, L; Agnello, M; Agostinis P.; Aguirre-Ghiso, JA; Ahn, HJ; et al. Review ISI AUTOPHAGY (2012)
Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications Andreu C.I.; Woehlbier, U; Torres M.; Hetz C. Review ISI SCOPUS FEBS Letters (2012)
The unfolded protein response: controlling cell fate decisions under ER stress and beyond Hetz C. Review ISI SCOPUS Nature Reviews Molecular Cell Biology (2012)
Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntington's Disease Vidal, R; Caballero, B; Hetz C. ; couve, a Review ISI SCOPUS Current Molecular Medicine (2011)
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat Rodriguez D.; Rojas-Rivera, D; Hetz C. Review ISI SCOPUS Biochimica et Biophysica Acta - Molecular Cell Research (2011)
Modulating stress responses by the UPRosome: A matter of life and death Woehlbier, U; Hetz C. Review ISI SCOPUS Trends in Biochemical Sciences (2011)
THE UNFOLDED PROTEIN RESPONSE: INTEGRATING STRESS SIGNALS THROUGH THE STRESS SENSOR IRE1 alpha Hetz C. ; Martinon, F; Rodriguez D.; Glimcher, LH Review ISI SCOPUS Physiological Reviews (2011)
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1 alpha Interactome Hetz C. ; Glimcher, LH Review ISI SCOPUS Molecular Cell (2009)
The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology Hetz C. ; Glimcher, L Review ISI TRENDS IN CELL BIOLOGY (2008)
The stress rheostat: An interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration Matus, S; Lisbona, F; Torres M.; Leon, C.; Thielen P; Hetz C. Review ISI CURRENT MOLECULAR MEDICINE (2008)
Beyond apoptosis: Nonapoptotic cell death in physiology and disease Hetz, C.A.; Torres V. Review ISI SCOPUS Biochemistry and Cell Biology (2005)
Molecular mechanisms of neurotoxicity of pathological prion protein Castilla J.; Hetz C. ; Soto C. Review ISI CURRENT MOLECULAR MEDICINE (2004)
Protein misfolding and disease: the case of prion disorders Hetz C. ; Soto C. Review ISI CELLULAR AND MOLECULAR LIFE SCIENCES (2003)

Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

Marcelo Baeza

Profesor Titular

Ciencias Ecologicas

Universidad de Chile

Santiago, Chile

Alvaro Glavic

Associate Professor

Departamento de Biología

Universidad de Chile

Santiago, Chile

Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Cecilia Vergara

Profesor Asociado

Biología

DEPARTAMENTO BIOLOGIA, FACULTAD DE CIENCIAS, U. DE CHILE

Santiago, Chile

Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Erwin Strahsburger

Instructor Professor

Universidad Arturo Prat

Iquique, Chile

Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

222

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Alicia Colombo

Profesora Asociada/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

Rosalba Lagos

Professor

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

Alexis Rivas

Investigador Postdoctoral

Instituto de Neurociencias Biomédicas

Universidad de Chile

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Nelson Osses

Associated Professor

Institute of Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

René Vidal

Profesor Asociado

Universidad Mayor

Santiago, Chile

Tatiana Adasme

Coordinadora de Estudios

Oficina de Apoyo a la Investigación Clínica

Universidad Chile

Santiago, Chile

Daniel Henriquez

Director Ciencia Transversal

Fundación Centro MERI

Santiago, Chile

Karen Castillo

Académica Investigadora

,Centro de Investigación de Estudios Avanzados del Maule (CIEAM)

Universidad Catolica del Maule

Talca, Chile

Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Hans Richter

Profesor Titular

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ariel Castro

Full Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

Patricio Manque

VICE PRESIDENT FOR RESEARCH AND FULL PROFESSOR

UNIVERSIDAD MAYOR

Santiago, Chile

Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

Eduardo Couve

Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

MIGUEL PEREZ

Associate Professor

Universidad Vina del Mar

Vina del Mar, Chile

Arlek Gonzalez

INVESTIGADOR POST-DOCTORAL

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA, UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

Patricio Godoy

Group leader

System sToxicology

Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund

Dortmund, Alemania

Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

Jose Matamala

Assistant Professor of Neurology

Department of Neurological Science

University of Chile

Santiago, Chile

Christian Gonzalez

Full Professor

Biologia

Universidad de Chile

Santiago, Chile

Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

Víctor Cornejo

Profesor Asistente

Facultad de Ciencias Biológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

Hery Urra

Staff scientist

INSTITUTO DE NEUROCIENCIA BIOMEDICA (BNI)

Santiago, Chile

Karina Palma

Postdoctorado

Instituto de Neurociencia Biomédica BNI

Universidad de Chile

Santiago, Chile

Gonzalo Cancino

Assistant Professor

Faculty of Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

Marcelo Catalan

Profesor Auxiliar

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

Pablo Mardones

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Melissa Calegaro

Principal Investigator, head lab

Research Vice Presidency

Universidad Mayor

Santiago, Chile

Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

Daniela López

Profesora Adjunta

UNIVERSIDAD DE VALPARAISO

Viña de Mar, Chile

Washington

Postdoctoral Researcher

Fundación Ciencia y Vida

Santiago, Chile

Natalia Salvadores

Profesora Asistente

Centro de Resiliencia, Adaptación y Mitigación

Universidad Mayor de Chile

Temuco, Chile

Felipe Beltrán

Gestor Tecnológico

I+D

Consorcio Apícola

Valdivia, Chile

Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

Marcelo Baeza

Valentina Valenzuela

Investigador Asociado

Centro de Biotecnologia

Universidad de Concepción

Concepción, Chile

Carol San Martín

Profesora Asistente

Neurología y Neurocirugía

Universidad de Chile

Santiago, Chile

Pedro Chana Cuevas

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

Gino Corsini

Director Instituto Ciencias Biomédicas

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

Maria Lisbona

Postdoctorado

Biología

Universidad de Chile

Santiago, Chile

Alfredo Sagredo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

Philippe Pihán

Posdoctorado

Fisiología

Universidad de Chile

Santiago, Chile

Alejandra Catenaccio

Asistente de Investigación

Universidad Mayor

HUECHURABA, SANTIAGO, Chile

Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

Alvaro Ardiles

Full Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

Claudio Cordova

Investigador asistente

Medicina

Universidad de Valparaíso

Valparaíso, Chile

Janina Borgonovo

PhD

Programa de Anatomía y Biología del Desarrollo

Universidad de Chile, Facultad de Medicina

Santiago, Chile

Cristina Pinto

Doctor en ciencias biologicas

Centro de Biotecnología

Universidad de Concepción

Concepción, Chile

Gabriela Martinez

Profesor Asociado

Filosofía y educación

Universidad Metropolitana de Ciencias de la Educación

santiago, Chile

Alexis Martinez

Investigador postdoctoral senior

Facultad de medicina

Instituto de Neurcoeincia Biomedica

Santiago, Chile

Felix Diaz

DENISSE SEPULVEDA

Postdoc

Universidad Mayor de Chile

Santiago, Chile

Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

Jorge Ojeda

Académico investigador

Ciencias Básicas y Morfología

Universidad Católica de la Santisima Concepción

Concepción, Chile

Viviana Pérez

Profesor Asistente

Fisiología

Universidad de Concepción

Concepcion, Chile

Carlos Rozas

Profesor asistente

Biologia

Universidad de Santiago de Chile

Santiago, Chile

Francisco Fuentes

Profesor Asistente

Departamento de Microbiología

Universidad de Concepción

Concepción, Chile

Camilo Allende

Docente

Universidad del Desarrollo

Santiago, Chile

Carolina Flores

Investigador Postdoctoral

Neurociencias

Universidad de Valparaíso

Valparaíso, Chile

Patricia Ojeda

Research Assistant

Facultad de medicina

Universidad de Chile

Santiago, Chile

Pablo Rozas

Investigador

SymbiOx

Santiago, Chile

Paulina Troncoso

Bioquimica PhD

Laboratorio Clínico Banco de Sangre Anatomía Patológica

Clínica Alemana de Santiago

Santiago, Chile

Celia Limia

N/A

N/A

Santiago, Chile

Valentina Castillo

Investigadora Postdoctoral

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

Andrés Gallardo

Marisol Cisternas

PHD c

Universidad Mayor de Chile

Santiago, Chile

sandra espinoza

asistente de investigacion

Laboratorio Neuroinmunologia

Fundacion Ciencias para la Vida/Universidad San Sebastian

Santiago, Chile

Estefania Lopez

Lab Manger /Asistente de investigacion

Neurociencias

Universidad de Chile

Santiago, Chile

Claudio Andres Hetz Flores

Líneas de Investigación

Educación

PhD. In Biomedical Sciences, UNIVERSIDAD DE CHILE. Chile, 2004

Molecular Biotechnology Engineer, UNIVERSIDAD DE CHILE. Chile, 2000

Postdoctoral Research Fellow, HARVARD SCHOOL OF PUBLIC HEALTH. Estados Unidos, 2005

Experiencia Académica

Postdoctoral Research Fellow Other

Postdoctoral Research Fellow Other

Profesor Asistente/ Investigador Principal Full Time

Adjunct Professor Other

Investigador Asistente Full Time

Profesor Adjunto Other

Full Professor and Principal Investigator Full Time

Director Other

Experiencia Profesional

Deputy Director Full Time

Profesor titular Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Santander Bank Award

KIA International Award

Target Validation Award

The Eppendorf & Science Prize for Neurobiology.

Highly Ranked Scholars™

Most cited scientist in the world

Most cited scientist in Chile

Highly Cited Scientist

Most cited scientist in Chile

Top 2% of most cited scientists

WSIS Prize 2022 Champion

Highly Cited Scientist

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