Man

Claudio Andres Hetz Flores

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Líneas de Investigación


Neurociencia; Biologia del Desarrollo; Biologia Molecular; Cellular Stress Related to Protein Misfolding; Cell Signaling and Apoptosis; Neurodegeneration

Educación

  •  PhD. In Biomedical Sciences, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Molecular Biotechnology Engineer, UNIVERSIDAD DE CHILE. Chile, 2000
  •  Postdoctoral Research Fellow, HARVARD SCHOOL OF PUBLIC HEALTH. Estados Unidos, 2005

Experiencia Académica

  •   Postdoctoral Research Fellow Other

    DANA-FARBER CANCER INSTITUTE

    Department of Cancer Immunology & AIDS

    Estados Unidos

    2004 - 2005

  •   Postdoctoral Research Fellow Other

    HARVARD SCHOOL OF PUBLIC HEALTH

    Chile

    2005 - 2007

  •   Profesor Asistente/ Investigador Principal Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2007 - 2010

  •   Adjunct Professor Other

    HARVARD SCHOOL OF PUBLIC HEALTH

    Estados Unidos

    2009 - 2016

  •   Investigador Asistente Full Time

    UNIVERSIDAD DE CHILE

    Chile

    2015 - A la fecha

  •   Profesor Adjunto Other

    THE BUCK INSTITUTE FOR RESEARCH ON AGING

    Estados Unidos

    2010 - A la fecha

  •   Full Professor and Principal Investigator Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Chile

    2010 - A la fecha

  •   Director Other

    Santiago, Chile

    2011 - A la fecha

Experiencia Profesional

  •   Deputy Director Full Time

    Biomedical Neuroscience Institute (BNI)

    Santiago, Chile

    2011 - A la fecha

  •   Profesor titular Full Time

    Universidad de Chile

    Santiago, Chile

    2010 - A la fecha

Premios y Distinciones

  •   Santander Bank Award

    Banco Santander

    Chile, 2016

    For outstanding contributions to University research on the area of neurological diseases

  •   KIA International Award

    Iranian Research Organization for Science and Technology

    Irán, 2015

    First place, for invaluable achievements and contributions to the development of science and technology. In addition, this price was accompanied by an UNESCO special awar

  •   Target Validation Award

    Michael J Fox Foundation for Parkinson Research

    Estados Unidos, 2014

    Para desarrollar terapia genica para el mal de Parkinson.

  •   The Eppendorf & Science Prize for Neurobiology.

    Science

    Chile, 2008

    Selected finalist by the editors of Science magazine as outstanding young scientist.


 

Article (28)

Adapting the proteostasis capacity to sustain brain healthspan
DEF8 and Autophagy-Associated Genes are Altered in Mild Cognitive Impairment, Probable Alzheimer’s Disease Patients and a Transgenic Model of the Disease
Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS
Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease
Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response
Genotoxic stress triggers the activation of IRE1 alpha-dependent RNA decay to modulate the DNA damage response
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates
Mastering organismal aging through the endoplasmic reticulum proteostasis network
Mechanisms, regulation and functions of the unfolded protein response
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease
The UPRosome-decoding novel biological outputs of IRE1 alpha function
When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response
beta-catenin aggregation in models of ALS motor neurons: GSK3 beta inhibition effect and neuronal differentiation
Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1 alpha
IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
Unraveling the role of motoneuron autophagy in ALS
IRE1 signaling exacerbates Alzheimer's disease pathogenesis
Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury
ALS-linked protein disulfide isomerase variants cause motor dysfunction
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

BookWhole (1)

Emerging roles of the unfolded protein response (UPR) in the nervous system: A link with adaptive behavior to environmental stress?

EditorialMaterial (1)

ER stress links aging to sporadic ALS

Generic (1)

Saved by the Matrix: UPR Independent Survival under ER Stress

Note (1)

ERp57 as a novel cellular factor controlling prion protein biosynthesis: Therapeutic potential of protein disulfide isomerases

Review (11)

Autophagy in hepatic adaptation to stress
Pharmacological targeting of the unfolded protein response for disease intervention
Small Molecules to Improve ER Proteostasis in Disease
Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease
The UFMylation System in Proteostasis and Beyond
ER stress and the unfolded protein response in neurodegeneration
Endoplasmic Reticulum Stress and the Hallmarks of Cancer
ER proteostasis addiction in cancer biology: Novel concepts
Proteostasis control by the unfolded protein response
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
Targeting the unfolded protein response in disease
43
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

6
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

6
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

4
Pablo Rozas

Asistente de Investigación

Instituto de Neurociencia Biomédica

Universidad de Chile

Santiago, Chile

3
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

3
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

3
Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

3
Viviana Pérez

Investigador Postdoctoral

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

3
Philippe Pihán

Posdoctorado

Fisiología

Universidad de Chile

Santiago, Chile

3
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

2
Celia Limia

N/A

N/A

Santiago, Chile

2
Hery Urra

Postdoctorado

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

2
DENISSE SEPULVEDA

Postdoc

Universidad Mayor de Chile

Santiago, Chile

2
Jorge Ojeda

Académico investigador

Ciencias Básicas y Morfología

Universidad Católica de la Santisima Concepción

Concepción, Chile

1
Jose Matamala

Assistant Professor of Neurology

Department of Neurological Science

University of Chile

Santiago, Chile

1
Ariel Castro

Associate Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

1
Arlek Gonzalez

INVESTIGADOR POST-DOCTORAL

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA, UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
Natalia Salvadores

investigador postdoctoral

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Hans Richter

Profesor Titular

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Melissa Calegaro

Investigadora Principal

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

1
Patricio Manque

VICE PRESIDENT FOR RESEARCH AND FULL PROFESSOR

UNIVERSIDAD MAYOR

Santiago, Chile

1
Karina Palma

Postdoctorado

Instituto de Neurociencia Biomédica BNI

Universidad de Chile

Santiago, Chile

1
Daniel Henriquez

Director Ciencia Transversal

Fundación Centro MERI

Santiago, Chile

1
Alvaro Glavic

Associate Professor

Departamento de Biología

Universidad de Chile

Santiago, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

1
Patricia Ojeda

Research Assistant

Facultad de medicina

Universidad de Chile

Santiago, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Claudia Duran-Aniotz

Profesor Asistente

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

1
Pedro Chana

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

1
Alejandra Catenaccio

Asistente de Investigación

Universidad Mayor

HUECHURABA, SANTIAGO, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
Alfredo Sagredo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

1
Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Paulina Troncoso

Inserción PhD

Investigación y Desarrollo

Neurognos SpA

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

1
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile