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Patricio Alfredo Godoy Tapia

Group leader

Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund

Dortmund, Alemania

Liver damage, liver regeneration, signal transduction, cell plasticity, hepatotoxicity, inflammation, transcriptional networks, stem cell-derived hepatocytes,

Dr. rer. nat (PhD), Universidad de Heidelberg. Alemania, 2009
Químico Farmacéutico, Universidad de Concepción. Chile, 2002

Profesor instructor Full Time

Universidad de Concepcion

Facultad de Farmacia

Concepcion, Chile

2002 - 2004
Profesor asistente Full Time

Universidad de Concepcion

Ciencias Biológicas

Concepcion, Chile

2014 - 2015

Group leader Full Time

Leibniz Research Centre IFADO

Dortmund, Alemania

2010 - 2014

Lecturer for course "Signal transduction" of Masters of Science program in Toxicology, University of Düssledorf, Germany. 2011-2013

Lecturer for elective course "Toxicological in vitro techniques and replacement for
animal experiments" of Master of Chemistry and Biochemistry, Ruhr Univestiry of Bochum. 2013

Co-supervision of PhD thesis of Agata Widera. Title: "Stress in the liver: stereotypic genomic responses in vitro and in vivo involve inflammation and loss of metabolic functions ", TU-Dortmund, Germany, 2010-2014

Co-supervision of PhD thesis of Gisela Campos. Title: "Genome-wide stress responses in stressed hepatocytes", TU-Dortmund, Germany 2010-2014

Supervisor Master thesis of Larissa Puetter. Title "Influence of in vitro microenvironment on cell plasticity of primary murine hepatocytes and their gene expression profile“. Fachhochschule Suedwesten, Iserlohn, Germany. 2013

Supervisor Master thesis of Franziska Zill. Title "The role of endoplasmic reticulum stress in hepatotoxicity in primary mouse hepatocytes". Fachhochschule Suedwesten, Iserlohn, Germany. 2012

Supervisor Master thesis of Regina Stoeber. Title "Expression and effects induced by Wnt-induced secreted protein-1 (Wisp1) in hepatocytes". TU-Dortmund, Germany. 2010-2011

Poster prize at Symposium "marketplace bio.dortmund"

LEIBNIZ INSTITUT FUR ANALYTISCHE WISSENCHAFTEN

Alemania, 2011

The Marketplace bio.dortmund symposium, held at the campus of the TU-Dortmund, brings together industry and academic research teams on biotechnology. The prize was awarded to the poster titled "Improving systems for toxicological testing: Transcriptomics, in vivo imaging and in silico disease modeling"


Adverse outcome pathways: opportunities, limitations and open questions Leist, Marcel; Ghallab, Ahmed; Graepel, Rabea; Marchan, Rosemarie; Hassan, Reham; Bennekou, Susanne Hougaard; Limonciel, Alice; Vinken, Mathieu; Schildknecht, Stefan; Waldmann, Tanja; et al. Article ARCHIVES OF TOXICOLOGY (2017)
Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests Shinde, Vaibhav; Hoelting, Lisa; Srinivasan, Sureshkumar Perumal; Meisig, Johannes; Meganathan, Kesavan; Jagtap, Smita; Grinberg, Marianna; Liebing, Julia; Bluethgen, Nils; Rahnenführer, Jörg; et al. Article ARCHIVES OF TOXICOLOGY (2017)
Functional modulation of glycine receptors by the alkaloid gelsemine Lara C.O.; Murath P.; Muñoz B.; Marileo A.M.; San Martín V.P.; Burgos, C. F.; Mariqueo, T. A.; Aguayo, L. G.; Fuentealba, J; Godoy, P; et al. Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2016)
Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue Widera, Agata; Schmidt-Heck, Wolfgang; Campos, Gisela; Meyer, Christoph; Cadenas, Cristina; Reif, Raymond; Stöber, Regina; Hammad, Seddik; Gianmoena, Kathrin; Marchan, Rosemarie; et al. Article ISI SCOPUS ARCHIVES OF TOXICOLOGY (2016)
Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases Ghallab, Ahmed; Cellière, Géraldine; Henkel, Sebastian G.; Driesch, Dominik; Hoehme, Stefan; Hofmann, Ute; Zellmer, Sebastian; Sachinidis, Agapios; Blaszkewicz, Meinolf; Reif, Raymond; et al. Article JOURNAL OF HEPATOLOGY (2016)
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells Godoy, P; Schmidt-Heck, W; Natarajan. K; Lucendo-Villarin, B; Szkolnicka D.; Asplund A.; Bjorquist, P; Widera A.; Stober, R; Campos, G.; et al. Article ISI JOURNAL OF HEPATOLOGY (2015)
Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes Cameron, Kate; Tan, Rosanne; Schmidt-Heck, Wolfgang; Campos, Gisela; Lyall, Marcus J.; Wang, Yu; Lucendo-Villarin, Baltasar; Szkolnicka, Dagmara; Bates, Nicola; Kimber, Susan J.; et al. Article Stem Cell Reports (2015)
Chronic CCl4 intoxication causes liver and bone damage similar to the human pathology of hepatic osteodystrophy: a mouse model to analyse the liver-bone axis Nussler AK, Wildemann B, Freude T, Litzka C, Soldo P, Friess H, Hammad S, Hengstler JG, Braun KF, Trak-Smayra V, Godoy P, Ehnert S Article ARCHIVES OF TOXICOLOGY (2014)
Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response Godoy P, Cadenas C, Hellwig B, Marchan R, Stewart J, Reif R, Lohr M, Gehrmann M, Rahnenführer J, Schmidt M, Hengstler JG Article Breast Cancer (2014)
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis Hammad S, Hoehme S, Friebel A, von Recklinghausen I, Othman A, Begher-Tibbe B, Reif R, Godoy P, Johann T, Vartak A, Golka K, Bucur PO, Vibert E, Marchan R, Christ B, Dooley S, Meyer C, Ilkavets I, Dahmen U, Dirsch O, Böttger J, Gebhardt R, Drasdo D, Heng Article ARCHIVES OF TOXICOLOGY (2014)
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity Campos, Gisela; Schmidt-Heck, Wolfgang; Ghallab, Ahmed; Rochlitz, Katherine; Putter, Larissa; Medinas, Danilo; Hetz, Claudio; Widera, Agata; Cadenas, Cristina; Begher-Tibbe, Brigitte; et al. Article ISI SCOPUS ARCHIVES OF TOXICOLOGY (2014)
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes. Schug M, Stöber R, Heise T, Mielke H, Gundert-Remy U, Godoy P, Reif R, Blaszkewicz M, Ellinger-Ziegelbauer H, Ahr HJ, Selinski S, Günther G, Marchan R, Blaszkewicz M, Sachinidis A, Nüssler A, Oberemm A, Hengstler JG Article ARCHIVES OF TOXICOLOGY (2013)
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Article ARCHIVES OF TOXICOLOGY (2013)
Identification of RARRES1 as a core regulator in liver fibrosis Teufel A, Becker D, Weber SN, Dooley S, Breitkopf-Heinlein K, Maass T, Hochrath K, Krupp M, Marquardt JU, Kolb M, Korn B, Niehrs C, Zimmermann T, Godoy P, Galle PR, Lammert F Article JOURNAL OF MOLECULAR MEDICINE-JMM (2012)
Human hepatocytes: isolation, culture, and quality procedures Knobeloch D, Ehnert S, Schyschka L, Büchler P, Schoenberg M, Kleeff J, Thasler WE, Nussler NC, Godoy P, Hengstler J, Nussler AK Article NEISSERIA MENINGITIDIS (2012)
In vitro - in vivo correlation of gene expression alterations induced by liver carcinogens Heise T, Schug M, Storm D, Ellinger-Ziegelbauer H, Ahr HJ, Hellwig B, Rahnenfuhrer J, Ghallab A, Guenther G, Sisnaiske J, Reif R, Godoy P, Mielke H, Gundert-Remy U, Lampen A, Oberemm A, Hengstler JG Article CURRENT MEDICINAL CHEMISTRY (2012)
Distinct role of endocytosis for Smad and non-Smad TGF-β signaling regulation in hepatocytes Meyer C, Godoy P, Bachmann A, Liu Y, Barzan D, Ilkavets I, Maier P, Herskind C, Hengstler JG, Dooley S Article JOURNAL OF HEPATOLOGY (2011)
Interfering with interferon-γ signalling in intestinal epithelial cells: selective inhibition of apoptosis-maintained secretion of anti-inflammatory interleukin-18 binding protein Schuhmann D, Godoy P, Weiss C, Gerloff A, Singer MV, Dooley S, Böcker U. Article Clinical Experimental Immunology (2011)
L-carnosine inhibits high-glucose-mediated matrix accumulation in human mesangial cells by interfering with TGF-β production and signalling Köppel H, Riedl E, Braunagel M, Sauerhoefer S, Ehnert S, Godoy P, Sternik P, Dooley S, Yard BA Article Nephrology, Dialysis & Transplantation (2011)
The network formation assay: a spatially standardized neurite outgrowth analytical display for neurotoxicity screening Frimat JP, Sisnaiske J, Subbiah S, Menne H, Godoy P, Lampen P, Leist M, Franzke J, Hengstler JG, van Thriel C, West J. Article LAB ON A CHIP (2010)
Dexamethasone-dependent versus -independent markers of epithelial to mesenchymal transition in primary hepatocytes Godoy P, Lakkapamu S, Schug M, Bauer A, Stewart JD, Bedawi E, Hammad S, Amin J, Marchan R, Schormann W, Maccoux L, von Recklinghausen I, Reif R, Hengstler JG Article BIOLOGICAL CHEMISTRY (2010)
Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice Braeuning A, Singh Y, Rignall B, Buchmann A, Hammad S, Othman A, von Recklinghausen I, Godoy P, Hoehme S, Drasdo D, Hengstler JG, Schwarz M. Article Histochemistry and Cell Biology (2010)
Reversible manipulation of apoptosis sensitivity in cultured hepatocytes by matrix-mediated manipulation of signaling activities. Godoy P, Schug M, Bauer A, Hengstler JG Article METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) (2010)
Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes Zellmer S, Schmidt-Heck W, Godoy P, Weng H, Meyer C, Lehmann T, Sparna T, Schormann W, Hammad S, Kreutz C, Timmer J, von Weizsäcker F, Thürmann PA, Merfort I, Guthke R, Dooley S, Hengstler JG, Gebhardt R Article HEPATOLOGY (2010)
Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis Godoy P, Hengstler JG, Ilkavets I, Meyer C, Bachmann A, Müller A, Tuschl G, Mueller SO, Dooley S Article HEPATOLOGY (2009)
The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis Weng HL, Liu Y, Chen JL, Huang T, Xu LJ, Godoy P, Hu JH, Zhou C, Stickel F, Marx A, Bohle RM, Zimmer V, Lammert F, Mueller S, Gigou M, Samuel D, Mertens PR, Singer MV, Seitz HK, Dooley S Article HEPATOLOGY (2009)
Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage Dooley S, Hamzavi J, Ciuclan L, Godoy P, Ilkavets I, Ehnert S, Ueberham E, Gebhardt R, Kanzler S, Geier A, Breitkopf K, Weng H, Mertens PR Article Gastroenterology (2008)
Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways Klingmüller U(1), Bauer A, Bohl S, Nickel PJ, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Götschel F, Hecht A, Walter D, Egger L, Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Bau Article IEE Proceedings - Systems Biology (2006)
An ELISA procedure for human Lp(a) quantitation using monoclonal antibodies Bustos, P.; Munoz M.; Ulloa N.; Godoy, P; Calvo C. Article ISI SCOPUS HYBRIDOMA AND HYBRIDOMICS (2002)


Plasma lipid changes in response to hormone replacement therapy in postmenopausal Chilean women are modified by apolipoprotein E genotype Calvo C.; Ulloa N.; Arteaga, E; Godoy, P; Bustos, A.; Munoz, R. Abstract ISI ATHEROSCLEROSIS SUPPLEMENTS (2003)


Highlight report: epoxide hydrolases-protection from reactive compounds and risk of cardiovascular disease Godoy, P; Aranda, M EditorialMaterial ISI SCOPUS Archives of Toxicology (2015)


Erratum: Gene networks and transcription factor motifs defining the differentiation of human stem cells into hepatocyte-like cells (Journal of Hepatology (2015) 63 (934-942)) Godoy, P; Natarajan. K; Szkolnicka D.; Asplund A.; Widera A.; Campos, G.; Hammad S.; Sachinidis A.; Chaudhari U.; Damm G.; et al. Errata SCOPUS Journal of Hepatology (2016)
Gene networks and transcription factor motifs defining the differentiation of human stem cells into hepatocyte-like cells (vol 63, pg 934, 2015) Godoy, P; Schmidt-Heck, W; Natarajan. K; Lucendo-Villarin, B; Szkolnicka D.; Asplund A.; Bjorquist, P; Widera A.; Stober, R; Campos, G.; et al. Errata ISI JOURNAL OF HEPATOLOGY (2016)