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JOSE LEONARDO GUZMAN GONZALEZ

Full professor

Universidad de Concepción

Concepcion, Chile

Líneas de Investigación


Molecular biology Molecular neurobiology Neurophamacology

Educación

  •  Cellular and Molecular Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2005
  •  Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1998

Experiencia Académica

  •   Full Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Faculty of Biological Sciences

    Concepcion, Chile

    2005 - A la fecha

  •   Subdirector de Postgrado Other

    UNIVERSIDAD DE CONCEPCION

    Dirección de Postgrado

    Concepción, Chile

    2018 - A la fecha

  •   Director de Departamento Part Time

    UNIVERSIDAD DE CONCEPCION

    Ciencias Biológicas

    Concepción, Chile

    2017 - 2018

  •   Director de Programa de Doctorado Part Time

    UNIVERSIDAD DE CONCEPCION

    Ciencias Biológicas

    Concepción, Chile

    2011 - 2014

Experiencia Profesional

  •   Postdoctoral Full Time

    University of Concepcion

    Concepcion, Chile

    2005 - 2008

Formación de Capital Humano


UNDERGRADUATE THESIS

ARIEL SALVATORE AVILA MACAYA, Biochemistry degree, “Analisis de la regulacion e interaccion de canales ionicos activados por ligando con G beta gamma”, December, 2008.

PIA MARIA VIOLE VIDAL VERA, Bioingeneer degree, “Activacion de proteinas G alfa por concentraciones farmacologicas de etanol”, December, 2008.

LORETO SOLEDAD SAN MARTIN VASQUEZ, Biochemistry degree, “Inhibicion del Efecto de Etanol en Receptor de Glicina por peptidos bloqueadores de Gbeta gamma”, March, 2011.

FABIAN CERDA, Bioingeneer degree, “Definicion de una estructura química no proteica para la inhibición de los efectos de etanol sobre el receptor de glicina”, 2011.

CAMILA ROMINA RIQUELME BAHAMONDES, Bioingeneer degree, “Efecto de etanol en el intercambio de GDP/GTP en las subunidades Galpha i1, Galpha OA, Galph aq”, March, 2011.

DANIELA ALEJANDRA NOVA BAZA, Biochemistry degree, “Efecto de etanol en el estado de disociación de la proteína G heterotrimerica”, March, 2012.

PILAR VASQUEZ. Undergraduate thesis "Diseño de ligandos peptídicos para el direccionamiento específico de nanotransportadores de farmacos al espacio sinaptico". Biochemistry degree.

POSTGRADUATE THESIS

LORETO SOLEDAD SAN MARTÍN VASQUEZ, Doctorado en Ciencias Biologicas area Biologia Celular y Molecular. 2016. Completed.

FABIAN CERDA, Magister en Bioquimica y Bioinformatica. “Busqueda de moléculas activas que inhiben la potenciacion del Receptor de Glicina por etanol a traves de G beta gamma”. November, 2013. Completed

SORAYA DEL CARMEN QUEZADA LOZANO, Magister en Fisiologia Humana. “Regulacion de la hormona liberadora de gonadotropina (GnRH) y aspectos fisiopatológicos”. December, 2013. Completed.

DANIELA GONZALEZ LEIVA, Magister en Fisiologia Humana. “Rol de Proteinas de la Densidad Postsinaptica Glutamatergica”. January, 2014. Completed,.

FELIPE BURGOS, PhD thesis, "Requerimientos moleculares y bioquímicos para la modulación por etanol de los receptores de glicina y GABAA", Doctorado en Ciencias Biologicas area Biologia Celular y Molecular. 2016. Completed.

FELIPE VIDAL, PhD thesis, "Estudio de la internalización celular y potencial uso como nanotransportadores de fármacos de dendrímeros PAMAM en neuronas". Doctorado en Ciencias Biologicas area Biologia Celular y Molecular. 2018. Completed.

CAMILO SAN MARTÍN. Master Thesis. "Rol del ejercicio físico en el control de la Diabetes Mellitus 2". Masther degree in Physiology. 2018. Completed.


Premios y Distinciones

  •   Premio Henri Nestle

    NESTLE CHILE S.A.

    Chile, 2011

    Co-suthor of the paper: Fuentealba J, Dibarrart AJ, Fuentes-Fuentes MC, Saez-Orellana F, Quiñones K, Guzmán L, Perez C, Becerra J, Aguayo LG. 2011. Synaptic failure and adenosine triphosphate imbalance induced by amyloid-? aggregates are prevented by blueberry-enriched polyphenols extract. J Neurosci 89(9):1499-508.

  •   Premio Henri Nestle

    NESTLE CHILE S.A.

    Chile, 2012

    Co-author of the paper: Fuentealba J, Dibarrart A, Saez-Orellana F, Fuentes-Fuentes MC, Oyanedel CN, Guzmán J, Perez C, Becerra J, Aguayo LG. Synaptic Silencing and Plasma Membrane Dyshomeostasis Induced by Amyloid-? Peptide are Prevented by Aristotelia Chilensis Enriched Extract. J Alzheimers Dis. 2012, 31(4):879-89.

  •   Asignacion Academica

    UNIVERSIDAD DE CONCEPCION

    Chile, 2016

    Recognition of scientific productivity and student formation. Periods: 2010 - 2012, 2013 - 2015 and 2016 - 2018.

  •   IUBMB and SBBq Award for best poster

    International Union of Biochemistry and Molecular Biology

    Brasil, 2015

    Poster selected as one of the 50th best of the meeting.


 

Article (41)

Mechanism-Based Rational Discovery and In Vitro Evaluation of Novel Microtubule Stabilizing Agents with Non-Taxol-Competitive Activity
Modulation of glycine receptor single-channel conductance by intracellular phosphorylation
Rational Design and In Vitro Evaluation of Novel Peptides Binding to Neuroligin-1 for Synaptic Targeting
Rational Design and In Vitro Evaluation of Novel Peptides Binding to Neuroligin-1 for Synaptic Targeting
Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers
Visible-light-responsive folate-conjugated titania and alumina nanotubes for photodynamic therapy applications
17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-beta Toxicity by Nicotinic Acetylcholine Receptors
Inhibitory Actions of Tropeines on the alpha 3 Glycine Receptor Function
Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors
Cytotoxicity and in vivo plasma kinetic behavior of surface-functionalized PAMAM dendrimers
P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease
Partially PEGylated PAMAM dendrimers as solubility enhancers of Silybin
Polyamido amine (PAMAM)-grafted magnetic nanotubes as emerging platforms for the delivery and sustained release of silibinin
Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization
ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of beta-amyloid peptide in hippocampal neurons
ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxiciw induced by soluble oligomers of beta-amyloid peptide in hippocampal neurons
Functional modulation of glycine receptors by the alkaloid gelsemine
Mechanism of PAMAM Dendrimers Internalization in Hippocampal Neurons
PAMAM-Conjugated Alumina Nanotubes as Novel Noncytotoxic Nanocarriers with Enhanced Drug Loading and Releasing Performances
PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications
Reversal of Ethanol-induced Intoxication by a Novel Modulator of Gbetagamma Protein Potentiation of the Glycine Receptor
Dendrimer nanocarriers drug action: perspective for neuronal pharmacology
Evidence for alpha-Helices in the Large Intracellular Domain Mediating Modulation of the alpha 1-Glycine Receptor by Ethanol and G beta gamma
Modulation of Neuronal Nicotinic Receptor by Quinolizidine Alkaloids Causes Neuroprotection on a Cellular Alzheimer Model
Inhibition of the Ethanol-induced Potentiation of alpha 1 Glycine Receptor by a Small Peptide That Interferes with G beta gamma Binding
Inhibition of the ethanol-induced potentiation of alpha1 glycine receptor by small peptide that interferes with G beta gamma
Synaptic Silencing and Plasma Membrane Dyshomeostasis Induced by Amyloid-beta Peptide are Prevented by Aristotelia chilensis Enriched Extract
Inhibitory Activities on Mammalian Central Nervous System Receptors and Computational Studies of Three Sesquiterpene Lactones from Coriaria ruscifolia subsp ruscifolia
Potentiation and inhibition of glycine receptors by tutin
Synaptic Failure and Adenosine Triphosphate Imbalance Induced by Amyloid-beta Aggregates Are Prevented by Blueberry-Enriched Polyphenols Extract
Molecular Requirements for Ethanol Differential Allosteric Modulation of Glycine Receptors Based on Selective G beta gamma Modulation
Blockade of Ethanol-Induced Potentiation of Glycine Receptors by a Peptide That Interferes with GB gamma Binding
Inhibitory effects of tutin on glycine receptors in spinal neurons
Molecular determinants for G protein beta gamma modulation of ionotropic glycine receptors
A g beta gamma stimulated adenylyl cyclase is involved in Xenopus laevis oocyte maturation
Human brain synembryn interacts with Gs alpha and Gq alpha and is translocated to the plasma membrane in response to isoproterenol and carbachol
(SN)-N-111 mutation in the helical domain of human Gs alpha reduces its GDP/GTP exchange rate
G alpha s levels regulate Xenopus laevis oocyte maturation
The C 2 cytosolic loop of adenylyl cyclase interacts with the activated form of G?s
Chemical modification of Genypterus maculatus arginase by Woodward's reagent K and diethyl pyrocarbonate: Evidence for an essential carboxylate and a nonessential, albeit important histidine residue
ELECTROPHORETIC PATTERNS OF LIPOPOLYSACCHARIDE OF ACINETOBACTER BAUMANNII FROM DIFFERENT SOURCES

Abstract (4)

CONTROL OF GAIN AND LOSS OF ETHANOL ALLOSTERIC POTENTIATION BY RESIDUES WITHIN THE GLYCINE RECEPTOR
The Gq alpha signaling pathway antagonizes Wnt8 induced-dorsalization in early embryonic development of Xenopus laevis.
Functional characterization of Xenopus laevis oocyte adenylyl cyclases
The (SN)-N-96 mutation in the helical domain of human gas affects its GDP/GTP exchange rate

ConferencePoster (10)

Mecanismos celulares de internalización de dendrímeros PAMAM
Design of Small molecules to inhibit the ethanol potentiation of Glycine receptor. In vivo evidences
Drug delivery from structured Al2O3/NT funcionalizated with PAMAM dendrimer.
Inhibition of etanol potentiation of glycine receptor by small molecules. In vitro and in vivo studies
PAMAM dendrimer functionalized TiO2 nanotubes as novel versatile platform for drug delivery
Study of celular internalization mechanism of polyamidoamine dendrimers drug nanocarriers.
Inhibición de la potenciación inducida por etanol del receptor de glicina por moléculas pequeñas que se unen a Gbeta gamma
Small molecules that inhibits ethanol potentiation of glycine receptors
Inhibition of the Ethanol-induced Potentiation of Glycine Receptor by Small Peptides and Molecules That Interfere with Gbeta gamma Binding.
Small molecules that inhibit ethanol potentiation of glycine receptors

Patent (2)

Moléculas que interaccionan con la proteína G con efecto inhibidor sobre la potenciación del etanol sobre el receptor de glicina en el sistema nervioso central
Moléculas que interaccionan con la proteína G, obstaculizando los efectos de etanol a nivel molecular en el sistema nervioso central

Proyecto (7)

Rational design of bioisosteric derivatives of lead compounds that inhibit the ethanol effects on glycine receptor
Desarrollo y Caracterización de Moléculas con Utilidad Clínica en Intoxicación Aguda con Etanol
Determination of the contact surface between G beta gamma and glycine receptor cytoplasmic domain
G beta gamma binding peptides that inhibit the ethanol potentiation of glycine receptor activity
Plan de Mejoramiento Institucional UCO1311 del Doctorado en Ciencias Biologicas area Biologia Celular y Molecular
Potentiation of Glycine Receptors by Ethanol
Rational design of bioisosteric derivatives of lead compounds that inhibits the ethanol effects on glycine receptor.

Review (2)

Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses
Historical and current perspectives of neuroactive compounds derived from Latin America
67
JOSE GUZMAN

Full professor

Fisiología

Universidad de Concepción

Concepcion, Chile

18
JORGE FUENTEALBA

Chairman

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

12
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

9
Veronica Jimenez

Assistant Professor

Chemistry

Universidad Andres Bello

Talcahuano, Chile

9
Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

8
Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

6
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

6
JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

6
Joel Alderete

Full Professor

Universidad de Talca

Talca, Chile

6
Carola Díaz

Investigadora Fondecyt Postdoctoral

Departamento de Química

Universidad Andrés Bello

Talcahuano, Chile

6
Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

5
Mario Silva

Emeritus Professor

Botany Department

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

5
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

4
Francisco Sáez

Postdoctoral Researcher

Institute of Neuroscience

Catholic University of Louvain

Brussels, Bélgica

4
Cristian Campos

Associate Professor

Físico-Química

Universidad de Concepción

Concepcion, Chile

4
Cecilia Torres

Profesor Asistente

Ciencias Químicas

UNIVERSIDAD ANDRES BELLO

Talcahuano, Chile

3
Ana Marileo

Tesista de Doctorado

De Fisiología

Universidad de Concepción

Concepción, Chile

3
Pamela Godoy

Estudiante doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

2
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Victoria San Martín

Tesista Doctorado

Fisiologia

Universidad de Concepción

Concepción, Chile

2
Maximiliano Figueroa

Assstant Professor

Universidad de Concepción

Concepción, Chile

2
Trinidad Mariqueo

Profesor Conferenciante

Escuela de Medicina

Universidad de Talca

Talca, Chile

2
Maximiliano Figueroa

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Javiera Gavilán

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

1
Pablo Murath

PhDc y COLABORADOR ACADÉMICO

CIENCIA Y TECNOLOGÍA DE LOS ALIMENTOS

UNIVERSIDAD DE CONCEPCIÓN

Concepción , Chile

1
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Marta Cecilia Bunster

DIRECTORA

Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Luis Barraza

ACADEMICO-INVESTIGADOR

DEPARTAMENTO DE CIENCIAS QUIMICAS

UNIVERSIDAD DE ANDRES BELLO

Concepción, Chile

1
Patricio Godoy

Group leader

System sToxicology

Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund

Dortmund, Alemania

1
Camila Bastidas

Docente

Universidad de Concepción

Concepción, Chile

1
Oscar Ramírez

Asistente de Investigación

Fisiología

Universidad de Concepción

Concepción, Chile

1
Juan Araya

Instructor

Análisis Instrumental

Universidad de Concepción

Concepción, Chile

1
Carlos Oyanedel

Research Assistant

Institute of Medical Psychology and Behavioral Neurobiology

Eberhard Karl University of Tübingen

Tübingen, Alemania

1
Apolinaria García

Investigador

Microbiology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Marcelo Muñoz

Profesor Auxiliar

Instituto de Ciencias Químicas

Universidad Austral de Chile

Valdivia, Chile

1
Raúl Zemelman

Investigador

Universidad Arturo Prat

Talcahuano, Chile

1
Jessica Panes

Alumna de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

1
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Matías Zúñiga

Postdoctorado

Centro de Bioinformática y Simulación Molecular

Universidad de Talca

TALCA, Chile