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Patricio Alejandro Castro Maldonado

profesor asociado

UNIVERSIDAD Concepcion

concepcion, Chile

Líneas de Investigación


Neurofisiologia; Neurofarmacologia; Biologia Celular y Molecular

Educación

  •  Licenciatura Bioquimica, UNIVERSIDAD DE CONCEPCION. Chile, 2003
  •  Doctor en Ciencias Biologicas, mencion Biologia Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 2012
  •  Bioquimico, UNIVERSIDAD DE CONCEPCION. Chile, 2005

Experiencia Académica

  •   PostDoc Full Time

    UC Davis

    sacramento, Estados Unidos

    2012 - 2014

Experiencia Profesional

  •   Colaborador Docente - Procesos Biologicos III (Medicina)

    Universidad Católica del Norte

    Chile

    2012 - 2012

  •   Alumno Ayudante de Departamento Fisiologia

    Universidad de Concepción

    Chile

    2006 - 2008

  •   Colaborador Docente - Talentos UdeC (Dr L Aguayo & Dr J Roa)

    Universidad de Concepción

    Chile

    2004 - 2009

  •   Colaborador Docente - Postgraduate Course FRONTIERS IN BRAIN DISEASES (Dr. Aguayo)

    Universidad de Concepción

    Chile

    2009 - 2009

  •   Colaborador Docente - Tecnicas Basicas de Laboratorio

    Universidad de Concepción

    Chile

    2009 - 2012

  •   Tesis Doctorado - Projecto NIH U01 (AA017875-01)

    Univ de Concepción -NIH - Univ Pittsburgh

    Chile

    2009 - 2012

  •   Postdoctorado

    UC Davis

    Estados Unidos

    2012 - 2014

  •   Estadia Investigacion (Dr. Gregg Homanics)

    University of Pittsburgh

    Estados Unidos

    2009 - 2009

  •   Estadia Investigacion (Dr. David Lovinger)

    NIH

    Estados Unidos

    2009 - 2009

  •   Estadia Investigacion (Dr. David Lovinger)

    NIH

    Estados Unidos

    2010 - 2010

  •   Encargado - Brain awareness week

    Univ Concepcion - Biblioteca Municipal

    Chile

    2011 - 2011

  •   Tesis Pregrado - Projecto Fondecyt (1020475)

    Univ de Concepción

    Chile

    2004 - 2005

  •   Tesis Doctorado - Projecto NIH R01 (AA15150-01)

    Univ de Concepción

    Chile

    2005 - 2006

  •   Colaborador - Proyecto Fundacion Andes (NºC14060/77) (Dr C Opazo)

    Univ de Concepción

    Chile

    2005 - 2006

  •   colaborador docente Farmacologia/Fisiopatologia para Kinesiologia

    universidad santo tomas

    Chile

    2016 - A la fecha

  •   colaborador Docente Psiquiatria (Neuro-desarrollo)

    universidad catolica del norte

    Chile

    2016 - A la fecha

  •   miembro comite etico cientifico UCN-COQ

    universidad catolica del norte

    Chile

    2016 - A la fecha


 

Article (30)

Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide

Lara, Cesar O.; Burgos, Carlos F.; Farina-Oliva, Katherine; Marileo, Ana M.; Martin, Victoria P. San; Flaig, David; Soto-Ortega, Paul; Contreras, Omayra V.; Sazo, Anggelo; Gaete-Riquelme, Krishna; et al.

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2025)

The Alkaloid Gelsemine Reduces Aβ Peptide Toxicity by Targeting Transglutaminase Type 2 Enzyme

Panes-Fernández, J; Marileo, AM; Espinoza-Rubilar, N; Meza, ME; Salgado-Martínez, BA; Gaete-Riquelme, K; Moraga-Cid G.; Castro P.A.; Burgos C.F.; Fuentealba J.; et al.

Article ISI SCOPUS
Plants  (2025)

Molecular Pharmacology of Gelsemium Alkaloids on Inhibitory Receptors

Marileo, AM; Lara C.O.; Sazo A.; Contreras, OV; Gonzalez G.; Castro P.A.; Aguayo L.G.; Moraga-Cid G.; Fuentealba J.; Burgos C.F.; et al.

Article ISI SCOPUS
International Journal of Molecular Sciences  (2024)

Metabolic imprint induced by seed halo-priming promotes a differential physiological performance in two contrasting quinoa ecotypes

Alvarez, Rodrigo; Fischer, Susana; Barros, Gabriel; Castro, Patricio A.

Article ISI SCOPUS
Frontiers in Plant Science  (2023)

Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine

Castro, Patricio A.; Burgos, Carlos F.

Article ISI SCOPUS
Frontiers in Molecular Neuroscience  (2023)

Nitrogen sources differentially affect respiration, growth, and carbon allocation in Andean and Lowland ecotypes of Chenopodium quinoa Willd

Jerez M.P.; Del Saz NF; Castro P.A.

Article ISI SCOPUS
Frontiers in Plant Science  (2023)

TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer's disease

Panes-Fernandeza, Jessica; Marileo, Ana; Castro, Patricio A.

Article ISI SCOPUS
Biomedicine and Pharmacotherapy  (2023)

Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure

Castro, Patricio A.

Article ISI SCOPUS
Neural Regeneration Research  (2022)

Increased P2×2 receptors induced by amyloid-β peptide participates in the neurotoxicity in alzheimer’s disease

Castro, Patricio

Article ISI SCOPUS
Biomedicine and Pharmacotherapy  (2021)

The Ω-3 fatty acid docosahexaenoic acid selectively induces apoptosis in tumor-derived cells and suppress tumor growth in gastric cancer

Cerda, Daniela; Castro, Patricio; CODDOU, Claudio

Article ISI SCOPUS
European Journal of Pharmacology  (2021)

Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects

Retamal, Claudio; CODDOU, Claudio; Castro, Patricio A.

Article ISI SCOPUS
Frontiers in Pharmacology  (2020)

Changes in PGC-1 alpha/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model

Panes, Jessica D.; Celis, Maria T.; Munoz-Montecino, Carola; Castro, Patricio A.; Salisbury, Jeffrey L.; Trushina, Eugenia

Article ISI SCOPUS
Frontiers in Pharmacology  (2020)

Modulation of glycine receptor single-channel conductance by intracellular phosphorylation

San Martín V.P.; Lara C.O.; Marileo, AM; Sazo A.; Muñoz-Montesino C.; Fuentealba J.; Aguayo, L. G.; Yévenes G.E.

Article ISI SCOPUS
Scientific Reports  (2020)

Seed characterization and early Nitrogen metabolism performance of seedlings from Altiplano and Coastal ecotypes of Quinoa

Briones, Vilbett; Alvarez, Rodrigo; Castro, Patricio A.

Article ISI SCOPUS
BMC Plant Biology  (2020)

Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers

Argel, Yenifer; Riquelme, Camila; Castro, Patricio; Yevenes, Gonzalo

Article ISI SCOPUS
Journal of Chemical Information and Modeling  (2020)

17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-beta Toxicity by Nicotinic Acetylcholine Receptors

Mennickent, Daniela; Ramirez-Molina, Oscar; Trivino, Sergio; Perez, Claudia; Godoy, Pamela A.; Becerra, Jose; Aguayo, Luis G.; San Martin, Victoria; Castro, Patricio A.

Article ISI SCOPUS
JOURNAL OF ALZHEIMERS DISEASE  (2019)

Differential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors

Castro, Patricio; Andres Madariaga, Juan; CODDOU, Claudio

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2019)

Inhibitory Actions of Tropeines on the alpha 3 Glycine Receptor Function

San Martin, Victoria P.; Burgos, Carlos F.; Marileo, Ana M.; Sazo, Anggelo; Castro, Patricio A.; Aguayo, Luis G.

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2019)

Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors

Burgos, Carlos F.; Aguayo, Luis G.; Castro, Patricio A.; Guzman, Jose L.

Article ISI SCOPUS
ACS Chemical Neuroscience  (2019)

NMDA Receptor Signaling Is Important for Neural Tube Formation and for Preventing Antiepileptic Drug-Induced Neural Tube Defects

Sequerra, EB; Goyal R.; Castro P.A.; Levin, JB; Borodinsky, LN

Article ISI SCOPUS
JOURNAL OF NEUROSCIENCE  (2018)

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372

Rokik, M

Article ISI SCOPUS
Pain  (2017)

Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?



Article
Frontiers in Cellular Neuroscience  (2016)

Evidence for alpha-Helices in the Large Intracellular Domain Mediating Modulation of the alpha 1-Glycine Receptor by Ethanol and G beta gamma

Burgos, C. F.; Mariqueo T.; Bunster M.; Guzman, L; Aguayo, L. G.

Article ISI SCOPUS
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS  (2015)

Altered Sedative Effects of Ethanol in Mice with alpha 1 Glycine Receptor Subunits that are Insensitive to G beta gamma Modulation

Aguayo L.G.; Castro P.; Mariqueo T.; Munoz B.; Xiong W.; Zhang L.; Lovinger D.M.; Homanics G.E.

Article ISI SCOPUS
NEUROPSYCHOPHARMACOLOGY  (2014)

The Basic Property of Lys385 Is Important for Potentiation of the Human alpha 1 Glycine Receptor by Ethanol

Figueroa, M; San Martin, L. S.; Aguayo, L. G.

Article ISI SCOPUS
Journal of Pharmacology and Experimental Therapeutics  (2012)

Abstracts-Posters



Article
Alcoholism: Clinical and Experimental Research  (2011)

Sustained increase of Ca+2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons

Larrucea, C; Castro P.; Sepúlveda, FJ; Wandersleben G.; Roa J.; Aguayo L.G.

Article ISI SCOPUS
BRAIN RESEARCH  (2008)

Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons

Castro P.; Sepúlveda, FJ; Gatica K.; Davis, MI; Aguayo L.G.

Article ISI SCOPUS
NEUROSCIENCE  (2007)

Glycinergic and GABAergic synaptic transmission are differentially affected by gephyrin in spinal neurons

van Zundert B.; Castro P.; Aguayo L.G.

Article ISI SCOPUS
BRAIN RESEARCH  (2005)

The presence of glia stimulates the appearance of glycinergic synaptic transmission in spinal cord neurons

Cuevas M.E.; Fuentes, YY; Castro P.; Nualart F.; Roa J.; Aguayo L.G.

Article ISI SCOPUS
MOLECULAR AND CELLULAR NEUROSCIENCE  (2005)

Abstract (1)

Elucidating the functional interaction between the intracellular domain of the glycine receptor α3 and the exocytosis complex protein SEC8

Soto P.; Flaig D.; Farina-Oliva, K; Quintana S.; De La Fuente, V; Millar C.; Castro P.; Fuentealba J.; Perez V.; Burgos C.F.; et al.

Abstract ISI
FEBS OPEN BIO  (2024)

BookSection (1)

Zn 2+ -protein interactions in normal brain physiology and neuropathology.

Opazo, Carlos; Castro, Patricio; Waldron, J; Parodi, Jorge; Fuentealaba, Jorge; Aguayo, Luis; Bernhardi R.V.; Inestrosa N.C.

BookSection
 (2008)

Errata (1)

Corrigendum to “The Ω-3 fatty acid docosahexaenoic acid selectively induces apoptosis in tumor-derived cells and suppress tumor growth in gastric cancer” [Eur. J. Pharmacol. (2021) 173910] (European Journal of Pharmacology (2021) 896, (S0014299921000637), (10.1016/j.ejphar.2021.173910))

Ortega L.; Lobos-González L.; Reyna-Jeldes M.; Cerda D.; De la Fuente-Ortega E.; Castro P.; Bernal G.; Coddou C.

Errata SCOPUS
European Journal of Pharmacology  (2021)

Review (2)

Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets

Castro P.A.; Pinto-Borguero I.; Yevenes G.E.; Moraga-Cid G.; Fuentealba J.

Review ISI SCOPUS
Frontiers in Pharmacology  (2022)

Potentiation of Gamma Aminobutyric Acid Receptors (GABA(A)R) by Ethanol How Are Inhibitory Receptors Affected?

Aguayo, L. G.

Review ISI SCOPUS
Frontiers in Cellular Neuroscience  (2016)

1
Marta Cecilia Bunster

DIRECTORA

Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

11
JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

2
Giuliano Bernal

Profesor Titular

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Maximiliano Figueroa

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
VILBETT BRIONES

Académico/Director de Escuela

Ingeniería en Alimentos

UNIVERSIDAD DE LA SERENA

la serena, Chile

3
Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

4
Luisa Bascuñán

Profesora asistente

Botánica

Universidad de Concepción

Concepción, Chile

7
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

3
Enrique Ostria

Profesor Asistente

Botánica

Universidad de Concepción

Concepción, Chile

1
Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

7
JOSE GUZMAN

Full professor

Fisiología

Universidad de Concepción

Concepcion, Chile

9
Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

1
Veronica Jimenez

Assistant Professor

Chemistry

Universidad Andres Bello

Talcahuano, Chile

2
Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

2
Trinidad Mariqueo

Profesor Conferenciante

Escuela de Medicina

Universidad de Talca

Talca, Chile

35
Patricio Castro

profesor asociado

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

3
Gustavo Moraga

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

1
Juan Tapia

Profesor Asociado

UNIVERSIDAD DE TALCA

Talca, Chile

2
Erwin de la Fuente

PROFESOR ASOCIADO

CIENCIAS BIOMÉDICAS

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

2
Teodoro Coba

Investigador Titular indefinido

BIOTEC

CORPORACION CENTRO DE ESTUDIOS AVANZADOS EN ZONAS ARIDAS

La Serena, Chile

5
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Máximo González

Investigador

Biotecnología

Centro de Estudios Avanzados en Zonas Aridas

La Serena, Chile

4
Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

2
Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

1
Darwin Leiva

Associate professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
Claudio Coddou

Profesor Asociado

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

1
Maximiliano Figueroa

Assstant Professor

Universidad de Concepción

Concepción, Chile

3
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

2
Loreto San Martín

1
Magdalena Cuevas

Profesor Asistente

Departamento de Fisiología

Universidad de Concepción

Concepción, Chile

2
SEBASTIAN RAMIREZ

Dr(c). Biología Aplicada

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

1
Maria Hevia

Prosefora

Ciencias Biomedicas

Universidad Cátolica del Norte

Coquimbo, Chile

1
Mauricio Reyna

Asistente de Investigación

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

4
JAVIERA GAVILAN

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

1
Jessica Panes

Alumna de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

6
Oscar Ramírez

PhD Candidate

Fisiología

Universidad de Concepción

Concepción, Chile

3
Pamela Godoy

Colaboradora académica

Fisiología

Universidad de Concepción

Concepcion, Chile

2
Victoria San Martín

Tesista Doctorado

Fisiologia

Universidad de Concepción

Concepción, Chile

1
Daniela Cerda

Asistente de Investigacion

Instituto Nacional de Investigaciones Agropecuarias

La Serena, Chile

2
Ana Marileo

Tesista de Doctorado

De Fisiología

Universidad de Concepción

Concepción, Chile

1
Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Pablo Lazcano

Asistente de Investigacion

CIIB

Universidad de Los Andes

Santiago, Chile

2
Daniela Mennickent

Académica

Departamento de Ciencias Básicas

Universidad Católica de la Santísima Concepción

Concepción, Chile