Man

Gustavo Alonso Moraga Cid

Profesor Asistente

Universidad De Concepción

Concepción, Chile

Líneas de Investigación


Relación estructura función de canales ionicos activados por ligando. Farmacología estructural de canales ionicos activados por ligando.

Educación

  •  Biología Celular y Molecular, UNIVERSIDAD DE CONCEPCION. Chile, 2009
  •  Biologo Marino, UNIVERSIDAD DE CONCEPCION. Chile, 2002

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CONCEPCION

    Facultad de Ciencias Biologícas

    Concepcion, Chile

    2016 - A la fecha

Experiencia Profesional

  •   Investigador Postdoctoral Full Time

    Institute Pasteur

    Paris, Francia

    2010 - 2015

  •   Investigador Postdoctoral Full Time

    Centre Nationale de la Recherche Scientifique (CNRS)

    Gif-sur-Yvette, Francia

    2015 - 2016


 

Article (32)

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain.
Altered glutaminase 1 activity during neurulation and its potential implications in neural tube defects
Changes in PGC-1α/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model
Inhibition of the glycine receptor alpha 3 function by colchicine.
Modulation of glycine receptor single-channel conductance by intracellular phosphorylation
Therapeutic Use of Vitamin C in Cancer: Physiological Considerations.
Data on SVCT2 transporter expression and localization in cancer cell lines and tissues
Increased expression of mitochondrial sodium-coupled ascorbic acid transporter-2 (mitSVCT2) as a central feature in breast cancer
Inhibitory Actions of Tropeines on the alpha 3 Glycine Receptor Function
Inhibitory Actions of Tropeines on the α3 Glycine Receptor Function
Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors
Plant growth promoting rhizobacteria with ACC deaminase activity isolated from Mediterranean dryland areas in Chile: Effects on early nodulation in alfalfa
Phosphorylation state?dependent modulation of spinal glycine receptors alleviates inflammatory pain
Allosteric and hyperekplexic mutant phenotypes investigated on an alpha(1) glycine receptor transmembrane structure
Control of Ethanol Sensitivity of the Glycine Receptor alpha 3 Subunit by Transmembrane 2, the Intracellular Splice Cassette and C-Terminal Domain
Intermediate closed state for glycine receptor function revealed by cysteine cross-linking
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
A Single Phenylalanine Residue in the Main Intracellular Loop of alpha 1 gamma-Aminobutyric Acid Type A and Glycine Receptors Influences Their Sensitivity to Propofol
Activated G Protein alpha(s) Subunits Increase the Ethanol Sensitivity of Human Glycine Receptors
Allosteric Modulation of Retinal GABA Receptors by Ascorbic Acid
Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family
Potentiation and inhibition of glycine receptors by tutin
Canonical Wnt3a Modulates Intracellular Calcium and Enhances Excitatory Neurotransmission in Hippocampal Neurons
Molecular Requirements for Ethanol Differential Allosteric Modulation of Glycine Receptors Based on Selective G beta gamma Modulation
Blockade of Ethanol-Induced Potentiation of Glycine Receptors by a Peptide That Interferes with GB gamma Binding
A selective G beta gamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol
Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2
Effects of pulp and paper mill discharges on caged rainbow trout (Oncorhynchus mykiss): Biomarker responses along a pollution gradient in the Biobio River, Chile
Molecular determinants for G protein beta gamma modulation of ionotropic glycine receptors
An RNA vaccine based on recombinant semliki forest virus particles expressing the Cu,Zn superoxide dismutase protein of Brucella abortus induces protective immunity in BALB/c mice
Reproductive, physiological, and biochemical responses in juvenile female rainbow trout (Oncorhynchus mykiss) exposed to sediment from pulp and paper mill industrial discharge areas
Intraspleen delivery of a DNA vaccine coding for superoxide dismutase (SOD) of Brucella abortus induces SOD-specific CD4(+) and CD8(+) T cells

Abstract (4)

CONTROL OF GAIN AND LOSS OF ETHANOL ALLOSTERIC POTENTIATION BY RESIDUES WITHIN THE GLYCINE RECEPTOR
Understanding the importance of intracellular regions in the glycine receptor for ethanol actions
G protein-dependent mechanisms for ethanol actions on glycine activated ion channels
Differential regulation of ethanol- and general anesthetic-induced modulation by the intracellular loop of glycine receptor.

ConferencePaper (1)

Developing a touchscreen-based domotic tool for users with motor disabilities

ConferencePoster (5)

Análisis de mutaciones causantes de hiperekplexia usando la estructura atómica del receptor de glycina humano.
Molecular mechanism underlying the functional inhibition of the glycine receptor 3 subunit by PKA-mediated phosphorylation
• Examination of the hiperekplexia phenotype in the x-ray structure of the human glycine receptor 1 subunit
• Modulación conformación-especifica de receptores inhibitorios: Una nueva aproximación hacia nuevos fármacos analgésicos
• Molecular sites for the modulation of glycine receptor by the analgesic alkaloid gelsemine

Proyecto (4)

Targeting glycine receptors for the treatment of chronic pain, hyperekplexia and anxiety: development of novel modulators based on recent structural and pharmacological insights
Aβ assemblies propagation and cell damage
Deciphering the functional and structural properties of the large intracellular domain of the pentameric ligand gated receptors”.
Molecular pharmacology of ethanol action on pentameric channel receptors based on their 3D structures: an electrophysiological study

Review (3)

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain
Therapeutic Use of Vitamin C in Cancer: Physiological Considerations
Potentiation of gamma aminobutyric acid receptors (GABAAR) by ethanol: How are inhibitory receptors affected?
49
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

14
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

9
Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

6
JOSE GUZMAN

Full professor

Fisiología

Universidad de Concepción

Concepcion, Chile

6
Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

5
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

5
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

3
Marcell Gatica

Profesora asistente

Bioquímica y Biología Molecular

Universidad de Concepción

Concepción, Chile

3
Maximiliano Figueroa

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

3
JORGE FUENTEALBA

Chairman

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

3
Maximiliano Figueroa

Assstant Professor

Universidad de Concepción

Concepción, Chile

3
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

3
Gustavo Moraga

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

3
Hugo Folch

Professor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

2
Abed Burgos

Docente part-time

Facultad de Ciencias

Universidad Católica de la Santísima Concepción

Concepción, Chile

2
Ricardo Barra

Profesor Titular

Sistemas Acuáticos

Facultad de Ciencias Ambientales/Centro EULA Chile

Concepción, Chile

2
Ariel Valenzuela

Prof. Asistente

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
mauricio gonzalez

phd

fisiopatologia

universidad de concepción

concepcion, Chile

2
Ana Marileo

Tesista de Doctorado

De Fisiología

Universidad de Concepción

Concepción, Chile

2
Luis Orrego

Associate Professor / Asociate Researcher

Faculty of Marine Science and Biological Resources

University of Antofagasta

Antofagasta, Chile

2
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

2
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Jessica Panes

Alumna de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

2
Victoria San Martín

Tesista Doctorado

Fisiologia

Universidad de Concepción

Concepción, Chile

1
Macarena Gerding

Profesor Asociado

Producción Vegetal

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE AGRONOMÍA

Chillán, Chile

1
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

1
Valeska Ormazabal

Profesor asistente

Farmacología

Universidad de Concepción

Concepción, Chile

1
CAROLINA DELGADO

Encargado de calidad Unidad de Anatomía Patológica

CR Diagnóstico Terapéutico

Hospital Regional Concepción HGGB

Concepcion, Chile

1
Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

1
Francisco Roa

Profesor Asistente

Fisiopatología, Facultad de Ciencias Biológicas

Universidad de Concepción

Concepción, Chile

1
Miguel Avila

Docente/Investigador

Universidad de las Américas

Santiago, Chile

1
Alejandro Reyes

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
MAFALDA MALDONADO

PROFESOR ASOCIADO

Fisopatología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
MARCELO VILLAGRAN

Profesor asociado

Departamento de Ciencias Básicas

Universidad Catolica de la Santísima Concepción

Concepcion, Chile

1
Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
BARBARA INZUNZA

profesor asistente

Biología Celular

Universidad de Concepción

Concepción, Chile

1
Pía Oyarzua

Jefe de Laboratorio

Producción Vegetal

Universidad de Concepción

Chillán, Chile

1
Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Gabriel Donoso

Investigador

Producción Vegetal

Instituto de Investigaciones Agropecuarias

Chillán, Chile

1
Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile