Man

Lorena Gisela Mardones Leiva

ASSOCIATED PROFESSOR

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

Líneas de Investigación


MOLECULAR EPIDEMIOLOGY, OXIDATIVE STRESS; REGULATION AND FUNCTION OF VITAMIN C TRANSPORTERS; FUNCTION OF GLUCOSE TRANSPORTER, KINETIC OF GLUCOSE TRANSPORTERS

Educación

  •  Biological Sciences, Cell and Molecular Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2007
  •  Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1997

Experiencia Académica

  •   ASSISTANT PROFESSOR Full Time

    UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

    MEDICINE

    CONCEPCION, Chile

    2009 - 2020

  •   TEACHING ASSISTANT Part Time

    UNIVERSIDAD DE CONCEPCION

    BIOLOGICAL SCIENCES

    Concepcion, Chile

    2005 - 2008

  •   TEACHING ASSISTANT Part Time

    UNIVERSIDAD REGIONAL SAN MARCOS

    CONCEPCION, Chile

    2008 - 2008

  •   PROFESOR ASOCIADO Full Time

    UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

    MEDICINA

    CONCEPCION, Chile

    2020 - A la fecha

Experiencia Profesional

  •   Jefe de Departamento Full Time

    Universidad Católica de la Santisima Concepción

    Concepcion, Chile

    2019 - 2021

Formación de Capital Humano


1. Tutor of Thesis (2014) Identification and localization of alpha-lactalbumin in mouse breast tissue at different stages of pregnancy and breastfeeding. Daniela Alvarez and Claudia San Martín. Career of Medical Technology . Universidad de Concepción.
2. Tutor of Thesis (2014) Effect of the soluble components of tobacco smoke in the activity of the antioxidant enzyme glutathione peroxidase. Valeria Cruz Ortega and Eduardo Silva Burgos. Career of Nutrition and Dietetic Universidad Católica de la Santísima Concepción.
3. Tutor of Seminar Research (2013) : Expression of glucose transporters in mammary gland. Daniela Alvarez and Claudia San Martín, Signatura Molecular Biology. Career of Medical Technology . Universidad de Concepción.
4. Tutor of Thesis (2013) Expression of GLUT8 in mammary gland during pregnancy, breastfeeding and weaning in murine model. Camila Venegas and Iván Ruminot. Career of Medical Technology . Universidad de Concepción.
5. Tutor of Thesis (2013) Effect of the soluble components of tobacco smoke in the activity of the antioxidant enzyme catalase. Paula Mennickent. Career of Nutrition and Dietetic.Universidad Católica de la Santísima Concepción.
6. Tutor Seminar Research (2012) : Expression of glucose transporters in mammary gland. Camila Venegas and Iván Ruminot, Course of Molecular Biology. Career of Medical Technology . Universidad de Concepción.
7. Training research of Mr. Esteban Parra, student of Medicine career. Universidad Católica de la Santísima Concepción (2013)
8. Responsible in Regular courses of CELL BIOLOGY to the career of Nutrition and Dietetic. Universidad Católica de la Santísima Concepción (2010-2014)
9. Responsible in Regular course of CELL AND MOLECULAR BIOLOGY to the career of Engineering in Aquaculture Biotechnology. Universidad Católica de la Santísima Concepción (2009-2013)
10. Responsible in Regular course of BIOLOGY to the career of Licenciature in Physic Education. Universidad Católica de la Santísima Concepción (2012)
11. Collaborator in Regular course of PATHOPHYSIOLOGY courses to the careers of Medicine, Odontology, Biochemist, Nursing, Obstetricia, Chemistry and Pharmacy, Kinesiology and Nutrition and Dietetic. Universidad de Concepción (2005-20108)
12. Collaborator in Regular courses of CELL BIOLOGY to the careers of Medicine and Nursing. Universidad Católica de la Santísima Concepción (2009-2014)
13. Collaborator in Regular course of DEVELOPMENT BIOLOGY to the career of Licenciature in Biology Universidad Católica de la Santísima Concepción (2012)
14. Responsible in Regular course of MOLECULAR BASES OF CHRONIC NON TRANSMISSIBLE DISEASES to the Master in Chronic non Transmissible Diseases. Universidad Católica de la Santísima Concepción (2012)
15. Collaborator in Regular course of MOLECULAR BASES OF CHRONIC NON TRANSMISSIBLE DISEASES to the Master in Chronic non Transmissible Diseases. Universidad Católica de la Santísima Concepción (2010)


Premios y Distinciones

  •   CONICYT Scholarship for Phd students

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 1996

    Scholarship from 1996 to 1999

  •   Scholarship Stipend for Phd Students

    UNIVERSIDAD DE CONCEPCION

    Chile, 2000

    Stipend Scholarship for Phd students, Graduate School at the University of Concepcion

  •   Scholarship Tuition Fees for PhD Students

    UNIVERSIDAD DE CONCEPCION

    Chile, 2001

    Scholarship tuition fees for PhD students, Graduate School of the University of Concepción Years 2001-2002

  •   Beca estancia postdoctoral corta

    FUNDACION CAROLINA

    España, 2021

    Estancia de 2 meses para enero-febrero 2022 en Universidad de las Islas Baleare, trabajo con Dra Joana Sanchez Roig


 

Article (36)

Cell-specific expression of functional glucose transporter 8 in mammary gland
Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment
Factors Associated with the Development of Type II Diabetes Mellitus: Evidence from Mendelian Randomization Studies
Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review
Association between cognitive impairment and depression in Chilean older adults
Association between FTO gene rs9939609 and adiposity markers in Chilean children
Childhood obesity: the benefits of breastfeeding versus formula feeding
From a global view to the Chilean context: which factors have influenced the development of obesity in Chile? (Chapter 1)
From a global view to the Chilean context: which factors have influenced the development of obesity in Chile? (Chapter 2)
The bitter reality of non-nutritive sweeteners: a global perspective applied to the Chilean context
The inheritance of COVID-19 pandemic
Total sugar consumption and its association with obesity in Chilean adults
Vitamin C and Cancer, friends or foes?
Association between adiposity levels and cognitive impairment in the Chilean older adult population
Association between sleep duration and cognitive impairment in older people
Association of rs3751812 polymorphism of the FTO gene with adiposity and metabolic markers in Chilean population. Results of the GENADIO study
Association of the TCF7L2 (RS7903146) genotype with adiposity and metabolic markers in the Chilean adult population
GLUT1 and GLUT8 support lactose synthesis in Golgi of murine mammary epithelial cells
Physical activity and sedentary behaviours are associated with cognitive impairment in Chilean older adults
Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults
Association of the FTO (rs9939609) genotype with energy intake
Patterns of healthy lifestyle behaviours in older adults: Findings from the Chilean National Health Survey 2009-2010
Catalase is more sensible to the inhibitory effect of soluble component of tobacco smoke than Glutathione Peroxidase and Superoxide Dismutase
Catalase is more sensible to the inhibitory effect of soluble component of tobacco smoke than Glutathione Peroxidase and Superoxide Dismutase [Catalasa es más sensible a los efectos inhibitorios de los componentes solubles del humo de tabaco que Glutatión Peroxidasa y Superóxido Dismutasa]
Efecto de una dieta alta en grasas en el proceso de formación de cálculos biliares de colesterol
Sustained blockade of ascorbic acid transport associated with marked SVCT1 loss in rat hepatocytes containing increased ascorbic acid levels after partial hepatectomy
Sustained blockade of ascorbic acid transport associated with marked SVCT1 loss in rat hepatocytes containing increased ascorbic acid levels after partial hepatectomy.
Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells
The glucose transporter-2 (GLUT2) is a low affinity dehydroascorbic acid transporter
Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2
Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione
Xanthine oxidase released from reperfused hind limbs mediate Kupffer cell activation, neutrophil sequestration and hepatic oxidative stress in rats subjected to tourniquet shock
Role of Küpffer cells and PMN leukocytes in hepatic and systemic oxidative stress in rats subjected to tourniquet shock
Inhibition of nitric oxide synthesis aggravates hepatic oxidative stress and enhances superoxide dismutase inactivation in rats subjected to tourniquet shock

Abstract (1)

EXPRESSION OF GLUCOSE TRANSPORTER 8 IS ASSOCIATED WITH LACTOSE SYNTHESIS IN MAMMARY GLAND OF MICE.

BookSection (1)

Lacytose Synthesis

ConferencePaper (1)

Bone Stroma induces AR basal transcriptional activity in prostate cancer cells

ConferencePoster (4)

Functional analysis of the facilitative hexose transporters GLUT10 and GLUT11, and characterization of novel dehydroascorbic acid transporters
Altered androgen receptor-dependent transcriptional activity in tumoral prostatic cells in the presence of bone stromal cells
Glutathione and vitamin C in the antioxidant defenses in endothelial cells exposed to cigarette smoke and oxidative stress
Glutahione regulates the ascorbic acid transporters in hepatocytes and rat hepatoma cells

Letter (1)

La trascendencia de la alimentación prenatal: Desde la hambruna holandesa hasta la realidad chilena

Proyecto (7)

Asociación entre el estados nutricional, los niveles de vitamina C, el estado redox y la prevalencia de polimorfismo de un solo nucleotido (SNP) del gen del co-transportadors SVCT1 en estudiantes de la uCSC
Valor nutricional y actividad biológica de algunas especies de algas de la Región del Biobío
Efecto de componentes del humo de cigarro en la actividad de enzimas antioxidantes
ROLE OF THE FACILITATIVE GLUCOSE TRANSPORTER GLUT8 IN MAMMARY GLAND DURING PREGNANCY AND LACTATION
Identificacion, caracterización funcional y localización subcelular de nuevos transportadores de ácido deshidroascórbico
VITAMINA C Y ESTRES OXIDATIVO=> MECANISMO Y FACTORES MODULADORES
PAPEL CENTRAL DE RADICALES SUPEROXIDO EN LA CAPTACION DE VITAMINA C EN CELULAS HUMANAS NORMALES Y NEOPLASICAS.

Review (2)

Una mirada actual de la vitamina C en salud y enfermedad
Vitamin C transporters
46
Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

13
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

12
MARCELO VILLAGRAN

Profesor asociado

Departamento de Ciencias Básicas

Universidad Catolica de la Santísima Concepción

Concepcion, Chile

11
Maria Martinez

Profesor Auxiliar

Instituto de Farmacia

Universidad Austral de Chile

Valdivia, Chile

9
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

9
Fanny Petermann

Lecturer

Universidad Diego Portales

Santiago, Chile

8
NATALIA ULLOA

Directora

Centro Vida Saludable

Universidad de Concepción

Concepción, Chile

7
Miquel Martorell

Profesor Asistente

Departamento de Nutrición y Dietética

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

5
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

5
Claudia Troncoso

Profesor Asociado; jefa de Departamento de Salud Pública

Salud Pública

Universidad Católica de la Santísima Concepción

Concepción, Chile

5
Fabian Lanuza

Investigador

Universidad de La Frontera

Temuco, Chile

4
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

4
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Reginald del Pozo

Profesor Asociado

Ciencias Básicas

Universidad Catolica de la Santisima Concepcion

Concepción, Chile

3
Carlos Celis

Research Fellow

Institute of Cardiovascular and Medical Sciences

University of Glasgow

Glasgow, Reino Unido

3
Valeska Ormazabal

Profesor asistente

Farmacología

Universidad de Concepción

Concepción, Chile

3
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
mauricio gonzalez

phd

fisiopatologia

universidad de concepción

concepcion, Chile

2
Nicole Lasserre

ACADÉMICO PLANTA

FACULTAD DE SALUD

Universidad Santo Tomás

LOS ANGELES , Chile

2
MAFALDA MALDONADO

PROFESOR ASOCIADO

Fisopatología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

2
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
CARLOS SALAS

Profesor Asociado

Educación Física

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Fredy Diaz

ASISTENTE

CIENCIAS BÁSICAS

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

Concepción, Chile

2
Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

2
Gabriela Nazar

Associate Professor

Psychology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Alejandro Reyes

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

2
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

2
Ximena Díaz

Coordinadora Grupo Investigación

Ciencias de la Educación

Universidad del Bío-Bío

Chillan, Chile

2
Ana Leiva

Directora

Instituto Anatomía Histología y Patología

Universidad Austral de Chile

Valdivia, Chile

2
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

2
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

2
PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

1
Marcell Gatica

Profesora asistente

Bioquímica y Biología Molecular

Universidad de Concepción

Concepción, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

1
Mirna Muñoz

Profesor Asistente

Ciencias Básicas

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

Concepción, Chile

1
JOSE SANTOS

Full Professor

Department of Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Ilona Concha

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

1
CAROL FLORES

Secretaría Académica de Postrgados Sede Concepción

Universidad Andrés Bello

Concepción , Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Elen Quispe

Académico

Facultad de Ciencias de la Salud

Universidad Arturo Prat

IQUIQUE, Chile

1
Yeny Concha

docente adjunto

salud

Universidad Santo Tomás

Talca, Chile

1
Cristian Álvarez

Profesor Asociado

School of Physical Therapy, Faculty of Rehabilitation Sciences

Universidad Andrés Bello

Santiago, Chile