Foto_carnet_m.rosa.jpg_thumb90

Maria Rosa Bono Merino

Profesor titular

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Inmunologi­a; Biologia de la celula dendritica; Polarizacion de la respuesta inmune; Homing linfocitario; Histocompatibilidad y trasplante; Lupus; Autoinmunidad

Educación

  •  Physical Chemistry, Université Paris XI. Francia, 1977
  •  Quimico, UNIVERSIDAD DE CHILE. Chile, 1974

Experiencia Académica

  •   Profesor titular Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    1991 - A la fecha

Experiencia Profesional

  •   CR1 Full Time

    C.N.R.S.

    Paris, Francia

    1983 - 1991

  •   Posdoc Full Time

    D.G.R.S.T.

    Paris, Francia

    1978 - 1980

  •   Research Associate Full Time

    Harvard University

    Boston, Estados Unidos

    1981 - 1983


 

Article (89)

Neosaxitoxin Inhibits the Expression of Inflammation Markers of the M1 Phenotype in Macrophages
P2X7 Receptor at the Crossroads of T Cell Fate
Pathogen-induced tissue-resident memory T(H)17 (T(RM)17) cells amplify autoimmune kidney disease
Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells
In Vitro-generated Tc17 cells Present a Memory Phenotype and serve as a reservoir of Tc1 cells In Vivo
Adoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response
Purinergic Signaling as a Regulator of Th17 Cell Plasticity
Retinoic Acid as a Modulator of T Cell Immunity
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs
The human thymus perivascular space is a functional niche for viral-specific plasma cells
Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration
Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance
Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection
CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression
CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells
Pro-Inflammatory Cytokines in Nasopharyngeal Aspirate From Hospitalized Children With Respiratory Syncytial Virus Infection With or Without Rhinovirus Bronchiolitis, and Use of the Cytokines as Predictors of Illness Severity
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation
Functional analysis reveals angiogenic potential of human mesenchymal stem cells from Wharton's jelly in dermal regeneration
Ca2+-Activated Cl- Channels of the ClCa Family Express in the Cilia of a Subset of Rat Olfactory Sensory Neurons
Dendritic and stromal cells from the spleen of lupic mice present phenotypic and functional abnormalities
Epithelial control of the human pDC response to extracellular bacteria
Levels of inflammatory cytokines and plasma cortisol in respiratory syncytial virus bronchiolitis
T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour
Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells
Increased Expression of the Glucocorticoid Receptor beta in Infants With RSV Bronchiolitis
Notch Signalling Regulates Cytokine Production by CD8+and CD4+T Cells
Delivery of Alloantigens via Apoptotic Cells Generates Dendritic Cells With an immature Tolerogenic Phenotype
Differential Regulation of Notch Ligands in Dendritic Cells upon Interaction with T Helper Cells
MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells
Retinoic Acid Generates Regulatory T Cells in Experimental Transplantation
T-cell homing to the gut mucosa: General concepts and methodological considerations
Cyclosporin A-treated Dendritic Cells may affect the outcome of organ transplantation by decreasing CD4(+)CD25(+) regulatory T cell proliferation
Dendritic Cells and B Cells Cooperate in the Generation of CD4(+)CD25(+)FOXP3(+) Allogeneic T Cells
Development of Murine Lupus Involves the Combined Genetic Contribution of the SLAM and Fc gamma R Intervals within the Nba2 Autoimmune Susceptibility Locus
Gap Junctions at the Dendritic Cell-T Cell Interface Are Key Elements for Antigen-Dependent T Cell Activation
Transforming Growth Factor-beta and All-Trans Retinoic Acid Generate Ex Vivo Transgenic Regulatory T Cells With Intestinal Homing Receptors
Alemtuzumab Induction in Kidney Transplantation: Clinical Results and Impact on T-Regulatory Cells
Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells
Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain
Generation of dendritic cells with regulatory properties
Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione
Immunization with antigen-pulsed dendritic cells significantly improves the immune response to weak self-antigens
Lymphoid B cells induce NF-kappa B activation in high endothelial cells from human tonsils
T helper 1/T helper 2 cytokine imbalance in respiratory syncytial virus infection is associated with increased endogenous plasma cortisol
Functional consequences of immune cell adhesión to endotelial cells
Interleukin-4 selectively inhibits interleukin-2 secretion by lipopolysaccharide-activated dendritic cells
Cyclosporine preconditions dendritic cells during differentiation and reduces IL-2 and IL-12 production following activation: A potential tolerogenic effect
Dendritic cells and the mode of action of anticalcineurinic drugs: an integrating hypothesis
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
Adhesion of B cell lines to endothelial cells from human lymphoid tissue modulates tyrosine phosphorylation and endothelial cell activation(1)
Isoforms of the class II transactivator protein
Low-dose prednisone accounts for a transient reduction on CD4(+) and CD8(+) T cells in renal transplant patients under triple therapy
MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator
Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines
CD4 and CD8 cytokine-producing T cells are transiently reduced following cyclosporine intake: Maximal inhibition occurs at 2 hours coincidental with drug C-max
Expression of the human SRY protein during development in normal male gonadal and sex-reversed tissues
Increased expression of c-rel, from the NF-kappa B/Rel family, in T cells from patients with systemic lupus erythematosus
A flow cytometric procedure for the quantification of cell adhesion in complex mixtues of cells
Differential expression of the MHC class II isotype chains
The human SRY protein is present in embryonic and adult Sertoli cells and germ cells
CIITA B-cell-specific promoter suppression in MHC class II-silenced cell hybrids
Outward currents in Drosophila larval neurons: dunce lacks a maintained outward current component down regulated by cyclic AMP
Isolation of a B cell-specific promoter for the human class II trans-activator
Spleen-derived stromal cells. Adhesion molecules expression and lymphocyte adhesion to reticular cell
Lymphocyte adhesion to endothelium derived human lymphoid tissue
The RAG cell line defines a new complementation group of MHC class II deficiency
Yeast artificial chromosome transfer into mammalian cells and comparative study of their integrit
Gene-dosage mapping of 30 DNA markers on chromosome 21
Human chromosome 16 encodes a factor involved in induction of class-II MHC antigens by interferon gamma
The recombinant human interferon-g receptor is fully functional in a human x murine hybrid containing human chromosome 21
Selection of mouse cells expressing an interferon-inducible hygromycin resistance : An approach for the cloning of the interferon-b receptor gene
Blocking of human T lymphocyte activation by channel antagonists
Characterisation of the human IFN-g response using somatic cell hybrids of hematopoietic and non-hematopoietic origin
Use of monoclonal antibody immunoaffinity columns to purify subsets of human HLA-DR antigens
NH2-terminal sequence of the a and b chains of human DC-1 antigen isolated from the JY cell line. Homology with murine I-A molecules
A homozygous human cell line contains three subsets of HLA-DR-Like antigens distinguishable by aminoacid sequencing
cDNA clone for the heavy chain of the human B cell alloantigen DC-1: Strong sequence homology to the HLA-DR heavy chain
Direct evidence of homology between human DC-1 antigen and murine I-A molecules
Characterisation of five human teratoma cell lines for their developmental properties and expression of embryonic and major histocompatibility locus associated antigens
Interferon enhances the amount of membrane bound b2-microglobulin and its release from human Burkitt cells
Selective expression of blood group antigens on human teratocarcinoma cell lines
Clinical, cytological, histological, immunological and hormonal studies in a case of true hermaphroditism
Methods of detection of H-Y antigen
"Monoclonal antibodies against HLA-D, DRw antigens
Enhanced expression of HLA antigens and b2-microglobulin on interferon treated cells
Electron in cold alcohols: a pulse radiolysis study in ethanol
Transplant tolerance: New insights and strategies for long-term allograft acceptance.

BookReview (1)

T cell homing to the gut mucosa: General concepts and methodological considerations

BookSection (2)

Citoquinas
La citometría de flujo: principios básicos y sus aplicaciones

Monograph (1)

Etude par radiolyse pulsée de la formation et de la réactivité de l'électron solvaté dans l'éthanol et le n-propanol à basses températures

Proyecto (24)

Thymic involution in autoimmune diseases
CD73-mediated adenosine production in the control of CD8+ T cell differentiation.
Papel de los macrófagos en el lupus eritematoso sistémico
B cell synapse in autoimmune diseases.
Cell sorter BD FACSAria III
Leukocyte trafficking as a determinant of autoimmunity
Fortalecimiento de la docencia y la investigación en las áreas de Inmunología y Biotecnología=> Inmunología del cáncer
The tumor microenvironment favors the generation of immunosuppressive Th17 cells
Utilización de células mesenquimáticas de cordón umbilical para activar la vascularización
Desarrollo de un método inmunológico mejorado para el sexaje de semen de ganado vacuno
Reprograming of regulatory T cells in gut immunity
Rol of dendritic cells in the development of lupus
Modulación de la respuesta inmune contra Neisseria Meningitidis por células epiteliales humanas de la orofaringe
Microambiente linfoide y polarización de la respuesta inmune
Modulación del homing en el sistema inmune
Las proteasas endosomales y la biología de las células dendríticas
Mecanismos que regulan la expresión de receptores de homing en linfocitos T
Papel funcional de las moléculas de histocompatibilidad de clase II inducidas por adhesión de los linfocitos B a células endoteliales
Inducción de las moléculas de histocompatibilidad de clase II por la adhesión linfocitaria
Regulación de la expresión de las moléculas de histocompatibilidad de clase- II. Alteraciones tumorales
Regulación de los genes de clase II del complejo mayor de histocompatibilidad
Microambiente linfoide y diferenciación linfocitaria
Vías de inducción de moléculas implicadas en la respuesta inmune por citoquinas
Interacciones que regulan el desarrollo linfocitario en órganos linfoides secundarios

Review (3)

Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
The essential role of chemokines in the selective regulation of lymphocyte homing
Functional consequences of immune cell adhesion to endothelial cells
98
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

45
Mario Rosemblatt

Executive Director

-

Fundacion Ciencia & Vida

Santiago, Chile

24
Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

8
Yessia Hidalgo

Flow Facility manager

Consorcio Regenero S.A.

Santiago, Chile

7
Sarah Nuñez

Investigador Postdoctoral

Laboratorio de Inmunología Celular y Molecular

Fundación Ciencia & Vida

Santiago, Chile

7
Gabriela Tejon

Investigador Postdoctoral

Biología

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

4
Aldo Gaggero

Académico. Profesor Asociado.

Virología

ICBM. FACULTAD DE MEDICINA. UNIVERSIDAD DE CHILE.

Santiago, Chile

4
Jaime De Calisto

Director Docente

Escuela de Biotecnología

Universidad Mayor

Santiago, Chile

4
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

4
Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Paulina Ruiz

Profesor Asistente

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

2
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

2
Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

2
Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

2
Jose Egana

Profesor asistente

Instituto de Ingeniería Biológica y Médica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
LILIAN REYES

Director de Escuela de Bioquímica

Universidad San Sebastián

Santiago, Chile

2
Rodrigo Naves

Associate Professor

Program of Immunology

Universidad de Chile

Santiago, Chile

2
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

2
Gonzalo Ureta

Investigador post doctoral

Fundación Ciencia y Vida

Santiago, Chile

2
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

2
Maria Loyola

Principal Investigator

Fundación Ciencia & Vida

Santiago, Chile

2
Andrés Ramirez

Flow Cytometry Facility Manager

Consorcio Regenero

Santiago, Chile

1
CATALINA PRIETO

Postdoctor

Biología

Universidad de Chile

Santiago, Chile

1
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Guillermo Zepeda

Profesor Asistente

Pediatría y Cirugía Infantil, Campus Norte

Universidad de Chile

Santiago, Chile

1
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Mabel Rivas

Titular

Pediatria

Hospital

Santiago, Chile

1
Jocelyn Neira

Especialista Profesional

Universidad Andrés Bello

Santiago, Chile

1
Gonzalo Valdivia

Division Head, Full Professor

Medical School

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
gabriela zavala

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

1
Ricardo Fernández

Associate Professor

Health

Universidad de Los Lagos

Osorno, Chile

1
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

1
Verónica Palma

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Victoria Guixé

Titular Profesor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jheimmy Diaz

Investigador Adjunto

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

1
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

1
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

1
Carlos Barrera

Funcionario

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

1
PATRICIO VARGAS

Profesor Titular

FISICA

USM

Valparaiso, Chile

1
Rosalba Lagos

Professor

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

1
Miguel del Campo

Investigador Adjunto Proyecto FONDECYT 151337

Fundación Ciencia y Tecnología para el Desarrollo

Santiago, Chile

1
Roxana Pincheira

Profesor Asociado

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

1
Patricia Burgos

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile