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Ivan Esteban Alfaro Cortez

Associate Professor, Director of Innovation and Technology Development

Universidad del Desarrollo

Santiago, Chile

Líneas de Investigación


Neuronal Proteostasis, with emphasis on the role of lysosomal mediated degradation and autophagy during physiological and pathological conditions in central nervous system synapses. Drug Discovery and Pharmacology of lysosomal modulators.

Educación

  •  PhD Biological Sciences, Cellular and Molecular Biology, Pontificia Universidad Católica de Chile. Chile, 2011
  •  Biochemistry, Pontificia Universidad Católica de Chile. Chile, 2005
  •  Quality Control Technician, Instituto Marítimo de Valparaíso. Chile, 1998
  •  MSc Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008

Experiencia Académica

  •   Adjunct Professor Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Faculty of Basic Sciences

    Valparaiso, Chile

    2010 - 2010

  •   Assistant Lecturer Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Faculty of Basic Sciencies

    Valparaíso, Chile

    2003 - 2004

  •   Full Professor Full Time

    Universidad de Playa Ancha

    Faculty of Natural and Exact sciences

    Valparaíso, Chile

    2015 - 2016

  •   Adjunct Professor Part Time

    Universidad de Viña del Mar

    Faculty of Health Sciencies

    Viña del Mar, Chile

    2016 - 2016

  •   Adjunct Professor Part Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Faculty of Health Sciences

    Santiago, Chile

    2015 - A la fecha

  •   Adjunct Professor Part Time

    UNIVERSIDAD SANTO TOMAS

    Faculty of Sciences

    Santiago, Chile

    2018 - A la fecha

  •   Associate Professor Full Time

    UNIVERSIDAD DEL DESARROLLO

    Faculty of Medicine

    Chile

    2020 - A la fecha

Experiencia Profesional

  •   Quality Control Supervisor Full Time

    Cervecería Santiago Ltda

    Santiago, Chile

    1996 - 1997

  •   Research Assistant Full Time

    Universidad Católica de Valparaíso

    Valparaíso, Chile

    2003 - 2004

  •   Postdoctoral Researcher Full Time

    Fundación Ciencia y Vida

    Santiago, Chile

    2011 - 2012

  •   Research Associate Full Time

    Fundación Ciencia y Vida

    Santiago, Chile

    2013 - 2015

  •   Postdoctoral Visiting Fellow Full Time

    Albert Einstein College of Medicine

    New York, Estados Unidos

    2014 - 2015

  •   Analyst, Discovery Biology Part Time

    Medivation Inc.

    Santiago, Chile

    2014 - 2015

  •   Full Professor Full Time

    Universidad de Playa Ancha

    Valparaíso, Chile

    2015 - 2016

  •   Research Associate Other

    Fundacion Ciencia y Vida

    Santiago, Chile

    2017 - A la fecha

  •   Director de Innovación y Desarrollo Tecnológico Other

    Universidad del Desarrollo

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


Thesis Directed or Co-Directed
2013-2015 PhD Thesis Co-Director "Discovery and characterization of neuroprotective beta-carboline derivatives in models of alpha-synuclein overexpression". Luz Delgado. PhD in Biotechnology. Andres Bello University. Chile.
2016- PhD Thesis Co-Director "Role of Chaperone Mediated Autophagy in Soluble Histone Degradation". Juan Hormazábal. PhD in Biotechnology. Andres Bello University. Chile.
2017- PhD Thesis Director "Negative regulation of chaperone-mediated autophagy modifies synaptic density and morphology during excitatory synaptogenesis.". Felipe Pérez de Arce. PhD in Biotechnology Andres Bello University. Chile.
2017-2018 Graduate Thesis Director "Effect of c-terminal truncation in alpha-synuclein degradation by autophagy pathways". Rodrigo Espinoza. Biochemistry Graduate Program. Pontificia Universidad Católica de Valparaíso. Chile.
2018-2019 Graduate Thesis Director "Study of the efect of Cationic Amphiphilic Drugs (CADs) in the activity of Chaperone Mediated Autophagy". Tamara Rojas. Biochemistry Graduate Program. Pontificia Universidad Católica de Valparaíso. Chile.
2019- Graduate Thesis Director "Role of Chaperone Mediated Autophagy in Excitatory Synaptic Development". Liliana Yantén. Biotechnology Engineering Graduate Program. Universidad de Santiago de Chile. Santiago. Chile.
2019- Graduate Thesis Director "Evaluation of the presence of Chaperone Mediated Autophagy in the nematode C.elegans". María Gallardo. Biotechnology Graduate Program. Universidad Santo Tomás. Santiago. Chile.


Difusión y Transferencia


Dissemination and Outreach Activities

Participation in Explora Conicyt program "1000 científicos 1000 Aulas"
2015 "How drugs are discovered and developed"
2016 "Neuronal plasticity during development"

2015 Co-Director Project "Didacticiencia" ED18D0053. Explora Conicyt Program for Science and Technology Disclosure Products 2015.

Technology Transfer

2015-2016 Medivation Inc. -Fundacion Ciencia y Vida Research Program. "Development of gamma-carboline analogues of latrepirdine for the treatment of Parkinson´s Disease and Related Synucleinopathies". Based in our discoveries about latrepirdine-induced degradation of alpha-synuclein protein in neuronal cells, this program lead to the developmen and discovery of several analogues of latrepirdine with alpha-synuclein degrading activities. Some of these analogues were pharmacologically characterized and tested in preclinical assays on in vivo models of syucleinopathies. A project for a Phase I Clinical Trial sponsored by Medivation Inc. and developed by Northwestern University was reached with one of these compounds (Prot#MDV1634-04: A Phase 1, Multicenter, Randomized, Double Blind, Placebo-Controlled, Safety and Dose FInding Biomarker Study of MDV1634 in Patients with Parkinson´s Disease).



 

Article (22)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells
Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis
Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors
PP32 and SET/TAF-I beta proteins regulate the acetylation of newly synthesized histone H4
Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors
The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons
Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide
Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
Latrepirdine stimulates autophagy and reduces accumulation of alpha-synuclein in cells and in mouse brain
Thiazolidinediones Promote Axonal Growth through the Activation of the JNK Pathway
Cognition-Enhancing Properties of Dimebon in a Rat Novel Object Recognition Task Are Unlikely to Be Associated with Acetylcholinesterase Inhibition or N-Methyl-D-aspartate Receptor Antagonism
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons
Up-regulation of CD95 (Apo-1/Fas) is associated with spermatocyte apoptosis during the first round of spermatogenesis in the rat
Kinetics, molecular basis, and differentiation of L-lactate transport in spermatogenic cells

Abstract (1)

Effect of MDV3100, a novel androgen receptor signaling inhibitor, on cell proliferation and tumor size in an apocrine breast cancer xenograft model

ConferencePoster (7)

Chaperone-mediated autophagy modulates synaptic differentiation in hippocampal neurons
Differential effects of autophagy activators in lipid droplets populations in hepatic cells
Discovery of cationic amphiphilic drugs that activate chaperone mediated-autophagy
Newly synthetized histone H3 is degraded by chaperone mediated autophagy
Discovery of small molecule alpha-synuclein degraders that activate chaperone mediated autophagy
Discovery of neuroprotective small molecules that induce alpha-synuclein degradation and activate lysosomal-dependent degradation
Discovery of novel anti-osteoclastogenic small molecules

ConferenceProceedingWhole (1)

Discovery of β-carboline modulators of chaperone mediated autophagy

Proyecto (6)

ROLE OF CHAPERONE MEDIATED AUTOPHAGY IN EXCITATORY SYNAPTIC DEVELOPMENT AND ELIMINATION
ROLE OF CHAPERONE MEDIATED AUTOPHAGY IN EXCITATORY SYNAPTIC DEVELOPMENT AND ELIMINATION
Beta-Carboline Modulators Of Chaperone Mediated Autophagy
BETA-CARBOLINE MODULATORS OF CHAPERONE MEDIATED AUTOPHAGY
PROGRAMA NACIONAL DE BECAS DE POSTGRADO - DOCTORADO - 2005
REGULACION DEL NUMERO DE ESPERMATOGONIAS POR MUERTE CELULAR PROGRAMADA=> POSIBLE PAPEL DE C-KIT Y FAS EN LA REGULACION DE LA ACTIVACION DE LAS CASPASAS
42
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

7
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Sebastian Bernales

Founder

Merken Biotech

Santiago, Chile

4
Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

3
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

3
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Mauricio Budini

Assistant Professor

Facultad de Odonotología

UNIVERSIDAD DE CHILE

Santiago, Chile

2
DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

2
Luz Delgado

Investigador

Fundacion Ciencia para la vida

Chile

2
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

2
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

1
Maria Loyola

Principal Investigator

Fundación Ciencia & Vida

Santiago, Chile

1
María Rauch

ACADEMICO

INSTITUTO DE BIOQUÍMICA Y MICROBIOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Christian Cea

Profesor Asistente

Escuela de Medicina

Universidad de Santiago de Chile

Santiago, Chile

1
Alfredo Molina

UNIVERSIDAD ANDRES BELLO

SANTIAGO, Chile

1
Amelina Albornoz

Post doctorado

Virología Molecular

Fundación Ciencia & Vida

Santiago, Chile

1
Alfredo Molina

Profesor Asistente

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

santiago, Chile

1
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

1
SarvaJit Chakravarty

Manager

Praxis Biotech LLC

San Francisco, Estados Unidos

1
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

1
Carmen Cea

ninguno

fruticultura

universidad de Chile

Santiago, Chile

1
Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

1
Rebeca Aldunate

Profesor Titular

Ciencias

UNIVERSIDAD SANTO TOMÁS

Santiago, Chile

1
Alicia Nogueras

Profesor Asociado Adjunto

Departamento de Biología Celular y Molecular

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

1
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Juan Hormazabal

Investigador Postdoctoral

Facultad De Medicina

Universidad del Desarrollo

Santiago, Chile