Man

Alfredo Guillermo Criollo Cespedes

Assistant professor

Facultad de Odontología, Universidad de Chile

Santiago, Chile

Líneas de Investigación


-Autophagy -Metabolism -Cell Death

Educación

  •  Biochemist, Universidad de Chile. Chile, 2004
  •  Ph.D. Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2009
  •  Ph.D. Molecular and Cellular Biology, Universidad de Paris. Francia, 2009

Experiencia Académica

  •   Assistant professor Full Time

    Fac de Odontología, Universidad de Chile

    Odontology

    Santiago, Chile

    2014 - A la fecha

Experiencia Profesional

  •   Post Doctoral Fellow Full Time

    UT Southwestern Medical Center

    Dallas, Estados Unidos

    2011 - 2014

  •   Assistant Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2014 - A la fecha

Formación de Capital Humano


Patricio Silva: Post-Doctorate Fellow FONDECYT

Elisa Villalobos : Ph.D. Student, Programa Doctorado en Nutrición. Universidad de Chile
Daniel Peña : Ph.D. Student, Programa Doctorado en Bioquímica. Universidad de Chile
Pablo Rivera: Ph.D. Student, Programa Doctorado en Bioquímica. Universidad de Chile
Jimena Gatica: Ph.D. Student, Programa Doctorado en Nutrición. Universidad de Chile

Cecilia Hernando: Undergraduated Student. Universidad de Chile
Nadia Hernández: Undergraduated Student. Universidad Iberoamericana de Ciencias y Tecnología
Sebastian Pino: Undergraduated Student. Universidad de Chile
Felipe Riquelme: Master Student. Universidad Nacional Andrés Bello
José Moreno: Undergraduated Student. Universidad de Chile


Difusión y Transferencia


2018 Organizer, International Workshop New Mechanisms of Autophagy in Chronic Diseases. Pontificia Universidad Católica de Chile. Santiago, Chile
2018 Autophagy in Stress, Development and Disease Gordon Research Conference. Lucca (Barga), Italy
2016 Organizer, ICGEB International Workshop. Autophagy: Physiological and Pathological Roles. Facultad de Odontología. Universidad de Chile.
2016 Organizer, Jornadas de Investigación y Expoinvestigacion de la Facultad de Odontología, Universidad de Chile.
2015 Organizer, Mesa redonda Autophagy: Expanding the Knowledge. Auditorium Abate Molina. Pontificia Universidad Católica de Chile.
2015 Organizer, International Simposium. Key Roles of Autophagy in Chronic Diseases.Puerto Varas. Chile.


Premios y Distinciones

  •   Ph.D. Fellowship CONICYT

    FONDECYT

    Chile, 2005

    Ph.D. Fellowship

  •   Ph.D. Fellowship Foundation pour la Recherché Médicale (FRM)

    Foundation pour la Recherché Médicale

    Francia, 2007

    Ph.D. Fellowship

  •   PhD Fellowship International Collaboration Program ECOS-CONICYT

    Conicyt

    Chile, 2005

    Ph.D. Fellowship International Collaboration Chile-France

  •   Medal Hermann Niemayer

    Sociedad Chilena de Bioquimica y Biologia Molecular

    Chile, 2007

    Best Ph.D student in Biological Sciences in Chile

  •   Grand Prix of the Chancellery of the Universities of Paris

    Chancellery of the Universities of Paris

    Francia, 2010

    Best Ph.D. thesis in Biomedical Sciences in the Paris Region


 

Article (77)

Histatin-1 is a novel osteogenic factor that promotes bone cell adhesion, migration, and differentiation
Mechanobiology of Autophagy: The Unexplored Side of Cancer
Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
New Emerging Roles of Polycystin-2 in the Regulation of Autophagy
Nuclear Accumulation of β-catenin Is Associated With Endosomal Sequestration of the Destruction Complex and Increased Activation of Rab5 in Oral Dysplasia
Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics
PKD2/polycystin-2 induces autophagy by forming a complex with BECN1
Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma
Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders
Fibroblast Primary Cilia Are Required for Cardiac Fibrosis
Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5
Polycystin-2 Is Required for Starvation- and Rapamycin-Induced Atrophy in Myotubes
Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Impact of estrogens and estrogen receptor-alpha in brain lipid metabolism
Polycystin-2-dependent control of cardiomyocyte autophagy
Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72
Hyperosmotic stress stimulates autophagy via polycystin-2
New Roles of the Primary Cilium in Autophagy
Poly(GP) proteins: a potential pharmacodynamic marker in ALS and FTD
Sex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors
The effects of oestrogens and their receptors on cardiometabolic health
Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Regulation of cardiomyocyte autophagy by calcium
Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability
Organelle communication: Signaling crossroads between homeostasis and disease
Role of Heterotrimeric G Protein and Calcium in Cardiomyocyte Hypertrophy Induced by IGF-1
Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway
Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death
An immunosurveillance mechanism controls cancer cell ploidy.
Autophagy is required for the activation of NFκB
Direct molecular interactions between Beclin 1 and the canonical NFκB activation pathway
Prognostic impact of vitamin B6 metabolism in lung cancer.
BH3 mimetics activate multiple pro-autophagic pathways
Illicit survival of cancer cells during polyploidization and depolyploidization
Inhibition of autophagy by TAB2 and TAB3
Longevity-relevant regulation of autophagy at the level of the acetylproteome
p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
Crosstalk between apoptosis and autophagy within the Beclin 1 interactome
miR-181a and miR-630 Regulate Cisplatin-Induced Cancer Cell Death
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress
The IKK complex contributes to the induction of autophagy
The life span-prolonging effect of sirtuin-1 is mediated by autophagy
Anti- and pro-tumor functions of autophagy
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
Control of autophagy by oncogenes and tumor suppressor genes
DRAM: a phylogenetically ancient regulator of autophagy
Induction of autophagy by spermidine promotes longevity
Stimulation of autophagy by the p53 target gene Sestrin2
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1
Senescence, Apoptosis or Autophagy? When a Damaged Cell Must Decide Its Path
A dual role of p53 in the control of autophagy
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells
Methods for assessing autophagy and autophagic cell death
Mutant p53 protein localized in the cytoplasm inhibits autophagy
p53 represses autophagy in a cell cycle-dependent fashion
Reduction of endoplasmic reticulum Ca2+ levels favors plasma membrane surface exposure of calreticulin
Regulation of autophagy by cytoplasmic p53
Senescence, apoptosis or autophagy?
BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
Cell cycle-dependent induction of autophagy, mitophagy and reticulophagy
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
Mitochondrial control of cell death induced by hyperosmotic stress
Regulation of autophagy by the inositol trisphosphate receptor
The inositol trisphosphate receptor in the control of autophagy
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death
Hyperosmotic stress-dependent NF kappa B activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of sorbitol and mannitol
Chronic High Fat Diet Consumption Impairs Metabolic Health of Male Mice.
Regulation of cardiomyocyte autophagy by calcium

Abstract (6)

Transcontinental characterization of the Hispanic BRCA1 3450del4 breast cancer founder mutation
Polycystin 2 is Required for Stress-induced Activation of Autophagy in Heart
Polycystin-1 Regulates Cardiac Hypertrophy via the L-type Calcium Channel
Apoptosis induced by hyperosmotic stress
IGF-1 prevents NF kappa B activation but not reactive oxygen species generation by hyperosmotic stress in apoptotic cultured cardiac myocytes
Hyperosmotic stress induces oxidative stress and NF kappa B activation in cultured cardiac myocytes

BookSection (2)

Autophagy networks in inflammation
Mutant p53 Located in the Cytoplasm Inhibits Autophagy

EditorialMaterial (1)

IKK connects autophagy to major stress pathways

Errata (1)

Mitochondrial control of cell death induced by hyperosmotic stress (vol 12, pg 3, 2007)

Proyecto (12)

Mechanisms of autophagy in obesity
Mechanisms of autophagy in Obesity
Polycystin2-Beclin-1=> a novel protein complex in autophagy regulation
Regulation of TDP-43 aggregation through Chaperone Mediated Autophagy pathway (CMA)=> implications in neurodegenerative diseases like ALS
Saturated fatty acids activate the fatty acid receptor GPR40=> implication in autophagy, inflammation and insulin sensitivity
REGULATION OF SKELETAL MUSCLE ATROPHY AND AUTOPHAGY BY POLYCYSTIN 2
CENTRO DE ESTUDIOS AVANZADOS DE ENFERMEDADES CRÓNICAS (ACCDIS)
Advanced Center for Chronic Diseases (ACCDiS)
Polycystin2-Beclin-1: a novel protein complex in autophagy regulation
Regulation of skeletal muscle atrophy and autophagy by polycystin 2
Regulation of TDP-43 aggregation through Chaperone Mediated Autophagy pathway (CMA): implications in neurodegenerative diseases like ALS
Saturated fatty acids activate the fatty acid receptor GPR40: implication in autophagy, inflammation and insulin sensitivity

Review (4)

New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages
A sexually dimorphic hypothalamic response to chronic high-fat diet consumption
Tumor Suppression and Promotion by Autophagy
Cardiomyocyte death: mechanisms and translational implications
98
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

27
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

22
Eugenia Morselli

Profesor Asociado de Planta Ordinaria

Fisiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago de Chile, Chile

12
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

9
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

7
Daniel Peña

Investigador postdoctoral

Departamento de Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

7
Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

7
Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Mauricio Budini

Assistant Professor

Facultad de Odonotología

UNIVERSIDAD DE CHILE

Santiago, Chile

5
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

4
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

3
Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

3
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

3
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
Zully Pedrozo

Assistant professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

2
Patricio Silva

Investigados Postdoctoral

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

2
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Alfredo Molina

Profesor Asistente

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

santiago, Chile

2
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

2
Cristina Bertocchi

Assistant Professor

Department of Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

2
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
CLAUDIA BAMBS

PROFESORA ASOCIADA

SALUD PÚBLICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

1
Amelina Albornoz

Post doctorado

Virología Molecular

Fundación Ciencia & Vida

Santiago, Chile

1
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

1
roberto vidal

Head of Pathogenic Escherichia coli Laboratory

Director Microbiology and Mycology Program

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
PATRICIA BURGOS

Associate Professor & Sub-Director CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pedro Torres

Ayudante laboratorio

Universidad de Chile

Santiago, Chile

1
CESAR RAMIREZ

Assistant Professor

Institute for Biological and Medical Engineering

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Claudio Perez

Profesor Asistente

Departamento de Ciencias Fisiológicas

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile