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Juan Andrés Orellana Roca

Associate Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Our research is focused on understand how the "crosstalk" between glial cells and neurons regulates various physiological and pathophysiological processes of the nervous system

Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010
Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
Biologist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Medicina

Santiago, Chile

2013 - 2017
Associate Reseacher Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Medicina

Santiago, Chile

2011 - 2013
Postdoctoral Fellow Full Time

ALBERT EINSTEIN COLLEGE OF MEDICINE

Medicine Faculty

Nueva York, Estados Unidos

2011 - 2011
Postdoctoral Fellow Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Ciencias Biológicas

Santiago, Chile

2010 - 2011
Associate Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Medicina

Santiago, Chile

2018 - A la fecha

Assistant Professor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2013 - 2018
Associate Professor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2018 - A la fecha

Undergraduate students supervised in last 5 years
- Beatriz Avendaño. Biotechnologist. Universidad de La Frontera (Finished)
- Rosario Gajardo. Biochemist. Pontificia Universidad Católica de Chile (Finished)
- Cristian Santibañez. Biochemist. Pontificia Universdidad Católica de Valparaiso (Finished)
- Luis Mellado. High School Teacher in Biology. Universidad Metropolitana de Ciencias de la Educación (Finished).
- Tanhia Alvear. Biotechnologist. Universidad Tecnológica Metropolitana (In course)
- Carla Inostrosa. Biotechnologist. Universidad Tecnológica Metropolitana (In course)
- Claudio Martinez. Biotechnologist. Universidad Tecnológica Metropolitana (In course)

Posdoctoral students supervised in last 5 years
- Carola Maturana. PhD Program in Biological Sciences, Mention Physiological Sciences. Pontificia Universidad Católica de Chile. (2016)
- Gonzalo Gómes. PhD Program in Biological Sciences, Mention Physiological Sciences. Pontificia Universidad Católica de Chile. (2016-present)

Herman Neimeyer Medal

Chilean Society of Biochemistry and Molecular Biology

Chile, 2009

Best Ph.D. student in Biomedical Sciences of Chile
Scientific career prize for PhD students

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2010

Awarded with the “Scientific career prize for PhD students” as a recognition by the Biological Science Faculty of the Pontificia Universidad Católica de Chile (2010).
Best PhD thesis

Cell Biology Society of Chile

Chile, 2010

Awarded with the “Best PhD thesis” as a recognition by the Cell Biology Society of Chile (2010).
best poster presentation in the International Gap Junction Conference 2011

International Gap Junction Society

Chile, 2011

Awarded with the "best poster presentation in the International Gap Junction Conference 2011" performed in Ghents, Belgium (2011).
Best PhD thesis

ACADEMIA CHILENA DE CIENCIAS

Chile, 2011

Awarded with the “Best PhD thesis” as a recognition by the Chilean Academy of Sciences (2011).
Matrícula de Honor

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2005

Scholarship to the best biology student for the promotion
Beca Juan Gomez Milla

Chilean Ministry of Education

Chile, 2001

Scholarship to high score obtained in the National Academic Aptitude University Test, Chile
PhD Fellowship.

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2006

Scholarship as a recognition by CONICYT
Thesis Support Fellowship for PhD student

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2007

Scholarship as a recognition by CONICYT
International Short Stay Grant for PhD student

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2007

Scholarship as a recognition by CONICYT and Evaluation-orientation de la Coopération Scientifique (ECOS)
International Short Stay Grant for PhD student

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2008

Scholarship as a recognition by CONICYT
Travel Grant for Attending Meetings.

International Brain Organization

Estados Unidos, 2008

Travel grant to PhD students to attend neurosciences meeting
International Postdoctoral Fellowship.

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2011

Scholarship support as a recognition by Program Improvement of Quality and Equity in Education (MECESUP) PUC 0708.
Travel stipend for Attending Meetings.

International Gap Junction Comitee

Estados Unidos, 2011

Travel grant to Postdocs to attend the International Gap Junction Conference
Travel Grant for Attending Meetings.

International Brain Organization

Chile, 2013

Travel grant to Postdocs to attend neurosciences meeting
Travel Grant for International Talks.

International Society for Neurochemistry

Chile, 2013

Travel grant to young scientist to attend The International society Meeting
Travel Grant for Attending Meetings.

International Brain Organization

Estados Unidos, 2015

Scholarship for young scientists to attend Neuroscience meetings
Travel stipend for Attending Meetings.

European Glia Network

España, 2015

Travel stipend for Attending the The XII European Meeting on Glial Cell Function in Health and Disease
International Short Stay Grant for Professors.

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2016

International Short Stay Grant for Professors
Miembro "Programa Ciencia de Frontera"

ACADEMIA CHILENA DE CIENCIAS

Chile, 2019

El programa Ciencia de Frontera, tiene como objetivo reconocer la excelencia y potencialidad de científicos jóvenes en diferentes áreas de las ciencias y vincularlos a las actividades de la Academia


Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR-dependent transmission and short-term fear memory in the basolateral amygdala Carvajal, Francisco J.; Tamburini, Giovanni; Antonio Verdugo, Daniel; Jury, Nur; Martinez, Pablo; van Zundert, Brigitte; Fiori, Mariana C.; Cerpa, Waldo; Orellana, Juan A.; Stehberg, Jimmy Article ISI FASEB JOURNAL (2022)
Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways Quintanilla, Rodrigo A. Article ISI ANTIOXIDANTS (2022)
TNF-alpha Plus IL-1 beta Induces Opposite Regulation of Cx43 Hemichannels and Gap Junctions in Mesangial Cells through a RhoA/ROCK-Dependent Pathway Balmazabal, Javiera; Fernandez, Paola; Orellana, Juan A.; Velarde, Victoria Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Astroglial Hemichannels and Pannexons: The Hidden Link between Maternal Inflammation and Neurological Disorders Liberona, Andres; Martinez-Araya, Claudio J.; Ramirez, Gigliola; Orellana, Juan A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Editorial: Astrocytes, a Kaleidoscope of Diversities, a Pharmacological Horizon Di Cesare Mannelli, Lorenzo; Ceruti, Stefania; Orellana, Juan A. Article ISI FRONTIERS IN PHARMACOLOGY (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abildgaard, Marie H.; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E.; Adolph, Timon E.; et al. Article ISI AUTOPHAGY (2021)
HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function Gajardo-GÃ³mez R.; SantibaÃ±ez C.A.; Labra V.C.; GÃ³mez G.I. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Interferon-gamma and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage Labra, Valeria C.; Velarde, Victoria; Orellana, Juan A. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)
Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species Giaume, Christian; Orellana, Juan A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Activation of Melanocortin-4 Receptor by a Synthetic Agonist Inhibits Ethanol-induced Neuroinflammation in Rats Orellana, Juan A.; Karahanian, Eduardo Article ISI SCOPUS CURRENT PHARMACEUTICAL DESIGN (2019)
Connexin 43 hemichannels and pannexin-1 channels contribute to the alpha-synuclein-induced dysfunction and death of astrocytes Labra, Valeria C.; Alvear, Tanhia F.; Mellado, Luis A.; Inostroza, Carla A.; Quintanilla, Rodrigo A.; Orellana, Juan A. Article ISI SCOPUS GLIA (2019)
Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease Vejar, Sebastián; Retamal, Mauricio A.; Ortiz, Fernando C.; Orellana, Juan A. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2019)
The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring AvendaÃ±o B.C.; Orellana J.A. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2019)
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment (vol 55, pg 4473, 2018) Tapia-Rojas, Cheril; Carvajal, Francisco J.; Orellana, Juan A.; Cerpa, Waldo; Quintanilla, Rodrigo A. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2018)
Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function Labra, Valeria C.; Santibañez, Cristian A.; Gajardo-Gómez, Rosario; Avendaño, Beatriz C.; Díaz, Esteban F.; Montero, Trinidad D.; Velarde, Victoria; Orellana, Juan A. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization Falcon, Romina V.; Maturana, Carola J.; Labra, Valeria C.; Salgado, Nicole; Rojas, Consuelo A.; Oyarzun, Juan E.; Cerpa, Waldo; Quintanilla, Rodrigo A.; Orellana, Juan A. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2018)
Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword Retamal, Mauricio A.; del Rio, Rodrigo; Orellana, Juan A. Article ISI SCOPUS Frontiers in Molecular Neuroscience (2018)
The Neuroglial Dialog Between Cannabinoids and Hemichannels Diaz, EF Article ISI SCOPUS Frontiers in Molecular Neuroscience (2018)
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment Mira, Rodrigo G.; Arce, Camila; Lerma-Cabrera, Jos? Manuel Article SCOPUS Molecular Neurobiology (2017)
Cannabinoids Prevent the Amyloid beta-Induced Activation of Astroglial Hemichannels: A Neuroprotective Mechanism Article ISI SCOPUS GLIA (2017)
New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis Lerma-Cabrera, José M.; Osorio-Fuentealba, Cesar Article ISI SCOPUS Frontiers in Cellular Neuroscience (2017)
Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions Gajardo-Gmez, Rosario; Labra, Valeria C.; Orellana, Juan A. Article ISI SCOPUS Frontiers in Molecular Neuroscience (2016)
Physiological Functions of Glial Cell Hemichannels Article ISI SCOPUS ARTERIAL CHEMORECEPTORS (2016)
Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases Orellana, Juan A.; Retamal, Mauricio A.; Stehberg, Jimmy Article SCOPUS FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2016)
Neuron-Glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis Rio R.D.; Quintanilla, R. A; Orellana J.A.; Retamal M.A. Article ISI SCOPUS Frontiers in Physiology (2015)
Prenatal Exposure to Inflammatory Conditions Increases Cx43 and Panx1 Unopposed Channel Opening and Activation of Astrocytes in the Offspring Effect on Neuronal Survival Avendano, BC; Montero TD; Chavez, CE; von Bernhardi R. Article ISI SCOPUS GLIA (2015)
Restraint stress increases hemichannel activity in hippocampal glial cells and neurons Article ISI SCOPUS Frontiers in Cellular Neuroscience (2015)
Excess cholesterol induces mouse egg activation and may cause female infertility Yesilaltay A.; Dokshin, GA; Busso, D.; Wang L.; Galiani, D; Chavarria, T; Vasile, E; Quilaqueo, L; Walzer, D; Shalgi, R; et al. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism Orellana JA, Sáez JC, Bennett MV, Berman JW, Morgello S, Eugenin EA Article ISI JOURNAL OF NEUROCHEMISTRY (2014)
Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet Busso, D.; Ramirez, G; Campos, M.; Rigotti A.; Eugenín J.; von Bernhardi R. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2014)
Role of Connexins and Pannexins in Ischemic Stroke Orellana J.A. Article ISI SCOPUS CURRENT MEDICINAL CHEMISTRY (2014)
Astrocytes Inhibit Nitric Oxide-Dependent Ca2+ Dynamics in Activated Microglia: Involvement of ATP Released Via Pannexin 1 Channels Montero TD; von Bernhardi R. Article ISI SCOPUS GLIA (2013)
Disruption in Connexin-Based Communication Is Associated with Intracellular Ca2+ Signal Alterations in Astrocytes from Niemann-Pick Type C Mice Sáez PJ; Vega-Riveros, N; Hernández DE; Klein, AD; Jiang JX; Zanlungo S. Article ISI SCOPUS PloS one (2013)
Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation Giaume C.; Froger, N; Retamal, M. Article ISI CONNEXIN CELL COMMUNICATION CHANNELS: ROLES IN THE IMMUNE SYSTEM AND IMMUNOPATHOLOGY (2013)
Pannexin1 hemichannels are critical for HIV infection of human primary CD4(+) T lymphocytes Velasquez S.; Williams, DW; Berman, JW; Eugenin, EA Article ISI SCOPUS Journal of Leukocyte Biology (2013)
Connexin-based channels in astrocytes: How to study their properties Giaume C.; Orellana J.A.; Abudara, V; Sáez, J.C. Article SCOPUS Methods in Molecular Biology (2012)
Glial hemichannels and their involvement in aging and neurodegenerative diseases von Bernhardi R.; Giaume C. Article ISI SCOPUS Reviews in the Neurosciences (2012)
Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels Orellana J.A.; Cortes-Campos, C; Contreras-Duarte, S; Figueroa, V.; Velarde, V; Nualart, F.; Sáez, J.C.; García M.A. Article ISI SCOPUS GLIA (2012)
Modulation of interferon-gamma-induced glial cell activation by transforming growth factor beta 1: A role for STAT1 and MAPK pathways Herrera-Molina, R; Flores, B; Orellana J.A.; von Bernhardi R. Article ISI SCOPUS Journal of Neurochemistry (2012)
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels Orellana J.A.; Schalper K.A.; Figueroa, V.; SANCHEZ, H.A.; Sáez, J.C. Article ISI SCOPUS ARTERIAL CHEMORECEPTORS (2012)
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala Stehberg, J; Moraga-Amaro, R; Salazar, C.; Becerra, A; Echeverria, C.; Orellana J.A.; Bultynck G.; Ponsaerts, R; Leybaert, L; Simon F; et al. Article ISI SCOPUS FASEB Journal (2012)
Amyloid beta-Induced Death in Neurons Involves Glial and Neuronal Hemichannels Shoji, KF; Abudara, V; Ezan P.; Amigou, E; Sáez PJ; Jiang JX; Naus, CC; Giaume C. Article ISI SCOPUS Journal of Neuroscience (2011)
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels Froger, N; Ezan P.; Jiang JX; BENNETT, MVL; Naus, CC; Giaume C. Article ISI SCOPUS Journal of Neurochemistry (2011)
Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species Diaz, E.; Vargas AA; BENNETT, MVL Article ISI SCOPUS Biochemical and Biophysical Research Communications (2011)
Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions Figueroa, XF; Contreras-Duarte, S; Velarde, V Article ISI SCOPUS CNS and Neurological Disorders - Drug Targets (2011)
Hypoxia in High Glucose Followed by Reoxygenation in Normal Glucose Reduces the Viability of Cortical Astrocytes Through Increased Permeability of Connexin 43 Hemichannels Hernández DE; Ezan P.; Velarde, V; BENNETT, MVL; Giaume C. Article ISI SCOPUS GLIA (2010)
Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective Froger, N; Calvo, CF; Amigou, E; Kozoriz, MG; Naus, CC; Giaume C. Article ISI SCOPUS Molecular and Cellular Neuroscience (2010)
Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments Froger, N; Cohen-Salmon, M; Ezan P.; Amigou, E; Giaume C. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2009)
Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells Verselis, VK Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Currently used methods for identification and characterization of hemichannels Palacios-Prado, N Article ISI SCOPUS CELL COMMUNICATION AND ADHESION (2008)
Chlorpromazine reduces the intercellular communication via gap junctions in mammalian cells Palacios-Prado, N Article ISI SCOPUS TOXICOLOGY AND APPLIED PHARMACOLOGY (2006)
Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats Dagnino-Subiabre, A; Carmona-Fontaine, C; Montiel, J; Diaz-Veliz, G; Seron-Ferre, M; wyneken u; Concha, ML; Aboitiz F. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2006)
Chronic stress impairs acoustic conditioning more than visual conditioning in rats: Morphological and behavioural evidence Dagnino-Subiabre, A; Terreros, G.; Carmona-Fontaine, C; Zepeda, R.; Diaz-Veliz, G; Mora S.; Aboitiz F. Article ISI SCOPUS NEUROSCIENCE (2005)


Prenatal exposure to inflammatory conditions increases hemichannel opening and activation of astrocytes in the offspring: repercussion on neuronal survival Avendano, B; Montero, T; Chávez, C.,; von Bernhardi R. Abstract ISI GLIA (2015)
Glutamate release through glial hemichannels: Focus on neuronal damage Abstract ISI JOURNAL OF NEUROCHEMISTRY (2013)
HIV INFECTION OF ASTROCYTES INCREASED RELEASE OF DICKKOF-1 (DKK1) PROTEIN BY A HEMICHANNEL-DEPENDENT MECHANISM Eugenin, E; Bennett M.; Berman, J; Morgello, S Abstract ISI JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2013)
SDF-1/CXCL12 induces migration of lymphocytes by a mechanism pannexin1 hemichannels dependent Velasquez S.; Eugenin, EA Abstract ISI JOURNAL OF NEUROVIROLOGY (2013)
HIV infection of astrocytes increases release of Dickkopf-1 protein by a gap junction and hemichannel dependent mechanism Orellana J.; Saez, J; Berman, J; Eugenin, E Abstract ISI JOURNAL OF NEUROVIROLOGY (2012)
SDF-1/CXCL12 induces migration of lymphocytes by a mechanism pannexin1 hemichannel dependent. Velasquez S.; Eugenin, EA Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2012)
Human Platelets Express Functional Pannexin-1 Pereira J.; Shoji, KF; Vargas AA; Saez CG; Pereira K; Paddock, C; Kuckleburg, C; Newman, PJ; Mezzano D. Abstract ISI BLOOD (2011)


Plasma membrane channels formed by connexins or pannexins in microglia: Possible role in the inflamed brain BookSection (2013)
Connexin based channels in astrocytes: how to study their properties R. Milner BookSection (2012)
Role of Connexin Hemichannels in Neurodegeneration Raymond Chuen-Chung Chang BookSection (2011)
Role of microglial activation in astroglial connexin expression and function leading to neurotoxicity Oviedo-Orta,; Kwak; Evans BookSection (2011)


SINGLE MEMBRANE CHANNELS FORMED BY CONNEXINS OR PANNEXINS: FOCUS ON THE NERVOUS SYSTEM BookWhole (2016)


Cannabinoids prevent the β-amyloid-induced hemichannel activity in neurons and glial cells ConferencePoster 48th Annual Meeting of Society for Neurosciences (2012)
Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species. Bennett, Michael VL ConferencePoster International Gap Junction Conference 2011 (2011)
Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels ConferencePoster International Gap Junction Conference 2009 (2009)
Increased astroglial hemichannel activity induced by β-amyloid is associated with neuronal death in brain slices ConferencePoster I CONGRESS IBRO/LARC OF NEUROSCIENCES FOR LATIN AMERICA, CARIBBEAN AND IBERIAN PENINSULA (2008)
Inhibition of Cx43 hemichannels prevents cortical astrocytes death induced by hypoxia in high glucose concentration ConferencePoster 48th Annual Meeting of THE AMERICAN SOCIETY FOR CELL BIOLOGY (2008)


Editorial: Single membrane channels formed by connexins or pannexins: focus on the nervous system EditorialMaterial ISI SCOPUS Frontiers in Cellular Neuroscience (2015)


FONDECYT Regular 1210375 "Disentangling the role of hemichannels and pannexons on astroglial and neuronal dysfunction induced by heavy ethanol exposure" Quintanilla, Rodrigo Arthur; Cerpa, Waldo Francisco Proyecto (2021)
FONDECYT Regular 1210940: Astrocytic cytokine signaling in multiple sclerosis: implications in disease progression Proyecto (2021)
CENTRAL ROLE OF ASTROCYTES IN NEURONAL-DRIVEN REMYELINATION Ortiz, Fernando; Orellana, Juan A.; Retamal, Mauricio Proyecto (2019)
CENTRAL ROLE OF ASTROCYTES IN NEURONAL-DRIVEN REMYELINATION PCI (ECOS C18S0) Proyecto 2019-2021 Coinvestigador(a)
REDES 190187: Network for Accelerating Research in Synaptic Impairment of Neurodegenerative Diseases: Novel Signaling Mechanisms Von Bernhardi, Rommy E. Proyecto (2019)
ROLE OF MITOCHONDRIAL OXIDATIVE STRESS IN ABNORMAL SYNAPTIC TRANSMISSION INDUCED BY TRAUMATIC BRAIN INJURY=> A LOOK FROM THE PERSPECTIVE OF THE TRIPARTITE SYNAPSE FONDEF (1190620) Proyecto 2019-2022 Coinvestigador(a)
Anillo ACT1411 "Centro de investigación para el estudio de la conducta del consumo de alcohol en adolescentes: De la molécula a la función cerebral y el metabolismo periférico" Karaharian, Eduardo Proyecto Orellana, Juan A. participates as Associate Investigator (2016)
FONDECYT Regular: "Uncovering the role of hemichannels in glial and neuronal dysfunction induced by alpha-synuclein" Proyecto (2016)
UNCOVERING THE ROLE OF HEMICHANNELS IN GLIAL AND NEURONAL DYSFUNCTION INDUCED BY ALPHA-SYNUCLEIN FONDECYT (1160710) Proyecto 2016-2020 Inv. Responsable
Centro de investigación para el estudio de la conducta del consumo de alcohol en adolescentes=> De la molécula a la función cerebral y el metabolismo periférico PIA (ACT1411) Proyecto 2015-2018 Coinvestigador(a)
Papel y regulación de los hemicanales en las dinámicas de Ca2+ intracelular entre células dela granulosa y ovocitos de ratón Proyecto (2015)
Role of astroglial cell hemichannels in prenatal LPS-induced neurotoxicity in the offspring Proyecto (2015)
Role of astroglial cell hemichannels in prenatal LPS-induced neurotoxicity in the offspring Committee for Aid and Education in Neurochemistry (CAEN), International Society for Neurochemistry (142015) Proyecto 2015-2016 Inv. Responsable
FONDECYT de Iniciación: "Role and regulation of glial cell hemichannels in maternal inflammation-induced brain dysfunction on the offspring" Proyecto (2012)
Role and regulation of glial cell hemichannels in maternal inflammation-induced brain dysfunction on the offspring FONDECYT (11121133) Proyecto 2012-2015 Inv. Responsable
PAPEL Y REGULACION DE LOS CANALES FORMADOS POR CONEXINA43 ASTROGLIAL EN LA DISFUNCION Y MUERTE CELULAR EN TEJIDO CEREBRAL IN VITRO INDUCIDA POR ISQUEMIA-REPERFUSION EN ALTA GLUCOSA. FONDECYT (1070591) Proyecto 2007-2011 Tesista
CARACTERIZACION DE MECANISMOS MODULADORES DEL ESTADO FUNCIONAL DE HEMICANALES DE LAS UNIONES EN HENDIDURA EN CELULAS DEL SISTEMA NERVIOSO CENTRAL. FONDECYT (1030945) Proyecto 2003-2007 Tesista


HEMICHANNELS: NEW PATHWAYS FOR GLIOTRANSMITTER RELEASE Montero TD Review ISI SCOPUS Neuroscience (2015)
Hemichannels: new roles in astroglial function Stehberg, J Review ISI SCOPUS Frontiers in Physiology (2014)
Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules Orellana JA, Martinez AD, Retamal MA. Review ISI SCOPUS Neuropharmacology (2013)
Connexin and pannexin hemichannels in inflammatory responses of glia and neurons Bennett, M. V. L.; Orellana J.A.; Nedergaard M.; Sáez, J.C. Review ISI SCOPUS Brain Research (2012)
Glial connexin expression and function in the context of Alzheimer's disease Koulakoff A.; Mei X.; Orellana J.A.; Sáez, J.C.; Giaume C. Review ISI SCOPUS Biochimica et Biophysica Acta - Biomembranes (2012)
The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System Eugenin, EA; Basilio D.; Raine, CS; Bukauskas, F; BENNETT, MVL; Berman, JW Review ISI SCOPUS Journal of Neuroimmune Pharmacology (2012)
Understanding Risk Factors for Alzheimer's Disease: Interplay of Neuroinflammation, Connexin-based Communication and Oxidative Stress Quintanilla, R. A; Orellana J.A.; von Bernhardi R. Review ISI SCOPUS Archives of Medical Research (2012)
Cell membrane permeabilization via connexin hemichannels in living and dying cells Shoji, KF; BENNETT, MVL Review ISI SCOPUS Experimental Cell Research (2010)
Dysfunctions of the Diffusional Membrane Pathways Mediated Hemichannels in Inherited and Acquired Human Diseases Berthoud VM. Review ISI CURRENT VASCULAR PHARMACOLOGY (2009)
Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration Sáez PJ; Shoji, KF; Palacios-Prado, N; Velarde, V; Giaume C.; BENNETT, MVL Review ISI ANTIOXIDANTS & REDOX SIGNALING (2009)
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion Shoji, KF; BENNETT, MVL Review ISI JOURNAL OF MEMBRANE BIOLOGY (2007)

Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Juan Montiel

Profesor Titular

FACULTAD DE MEDICINA

UNIVERSIDAD DIEGO PORTALES

Santiago, Chile

Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

Ariel Castro

Full Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

101

Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Vania Figueroa

Directora InES Género y CTGénero, Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Alexies Dagnino

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

Mauricio Retamal

Associate Professor

Programa de Comunicación Celular en Cancer

Universidad del Desarrollo

Santiago, Chile

Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Gonzalo Gomez

Profesor Asistente

Instituto de Ciencias de la Saluda

Universidad Autónoma de Chile

Santiago, Chile

Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Alfredo Criollo

Associated Professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

HELMUTH SANCHEZ

INVESTIGADOR ADJUNTO

Laboratorio de Conexinas y Panexinas

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

VALPARAISO, Chile

Fernando Ortiz

profesor asistente

Departmento de Biología, Facultad de Quimica y Biología

Universidad de Santiago de Chile

Santiago, Chile

Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

Gonzalo Terreros

Assistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

Trinidad Montero

postdoctorate

Medicine

Pontificia Universidad Católica de Chile

Santiago, Chile

Nicole Salgado

Coordinador

Facultad de Ciencias Biologicas

Pontificia Universidad Católica de Chile

Santiago, Chile

Juan Prieto

Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

Rodrigo Moraga

Postdoctoral researcher

Nuklear Medizin

Medizinische Hochschule Hannover

Hannover, Alemania

Claudia Lucero

Profesor-Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Andrés Liberona

Asistente de Investigación

Neurociencias

Universidad de Chile

Santiago de Chile, Chile

Esteban Díaz

Research Assistant

Department of Biology

Universidad de Santiago de Chile

Santiago, Chile

Juan Andrés Orellana Roca

Líneas de Investigación

Educación

Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010

Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007

Biologist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

Assistant Professor Full Time

Associate Reseacher Full Time

Postdoctoral Fellow Full Time

Postdoctoral Fellow Full Time

Associate Professor Full Time

Experiencia Profesional

Assistant Professor Full Time

Associate Professor Full Time

Formación de Capital Humano

Premios y Distinciones

Herman Neimeyer Medal

Scientific career prize for PhD students

Best PhD thesis

best poster presentation in the International Gap Junction Conference 2011

Best PhD thesis

Matrícula de Honor

Beca Juan Gomez Milla

PhD Fellowship.

Thesis Support Fellowship for PhD student

International Short Stay Grant for PhD student

International Short Stay Grant for PhD student

Travel Grant for Attending Meetings.

International Postdoctoral Fellowship.

Travel stipend for Attending Meetings.

Travel Grant for Attending Meetings.

Travel Grant for International Talks.

Travel Grant for Attending Meetings.

Travel stipend for Attending Meetings.

International Short Stay Grant for Professors.

Miembro "Programa Ciencia de Frontera"

Article (53)

Abstract (7)

BookSection (4)

BookWhole (1)

ConferencePoster (5)

EditorialMaterial (1)

Proyecto (17)

CENTRAL ROLE OF ASTROCYTES IN NEURONAL-DRIVEN REMYELINATION

ROLE OF MITOCHONDRIAL OXIDATIVE STRESS IN ABNORMAL SYNAPTIC TRANSMISSION INDUCED BY TRAUMATIC BRAIN INJURY=> A LOOK FROM THE PERSPECTIVE OF THE TRIPARTITE SYNAPSE

UNCOVERING THE ROLE OF HEMICHANNELS IN GLIAL AND NEURONAL DYSFUNCTION INDUCED BY ALPHA-SYNUCLEIN

Centro de investigación para el estudio de la conducta del consumo de alcohol en adolescentes=> De la molécula a la función cerebral y el metabolismo periférico

Role of astroglial cell hemichannels in prenatal LPS-induced neurotoxicity in the offspring

Role and regulation of glial cell hemichannels in maternal inflammation-induced brain dysfunction on the offspring

PAPEL Y REGULACION DE LOS CANALES FORMADOS POR CONEXINA43 ASTROGLIAL EN LA DISFUNCION Y MUERTE CELULAR EN TEJIDO CEREBRAL IN VITRO INDUCIDA POR ISQUEMIA-REPERFUSION EN ALTA GLUCOSA.

CARACTERIZACION DE MECANISMOS MODULADORES DEL ESTADO FUNCIONAL DE HEMICANALES DE LAS UNIONES EN HENDIDURA EN CELULAS DEL SISTEMA NERVIOSO CENTRAL.

Review (11)