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Juan Andrés Orellana Roca

Associate Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Our research is focused on understand how the "crosstalk" between glial cells and neurons regulates various physiological and pathophysiological processes of the nervous system

Educación

  •  Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010
  •  Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Biologist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2013 - 2017

  •   Associate Reseacher Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2011 - 2013

  •   Postdoctoral Fellow Full Time

    ALBERT EINSTEIN COLLEGE OF MEDICINE

    Medicine Faculty

    Nueva York, Estados Unidos

    2011 - 2011

  •   Postdoctoral Fellow Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Ciencias Biológicas

    Santiago, Chile

    2010 - 2011

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Assistant Professor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2013 - 2018

  •   Associate Professor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2018 - A la fecha

Formación de Capital Humano


Undergraduate students supervised in last 5 years
- Beatriz Avendaño. Biotechnologist. Universidad de La Frontera (Finished)
- Rosario Gajardo. Biochemist. Pontificia Universidad Católica de Chile (Finished)
- Cristian Santibañez. Biochemist. Pontificia Universdidad Católica de Valparaiso (Finished)
- Luis Mellado. High School Teacher in Biology. Universidad Metropolitana de Ciencias de la Educación (Finished).
- Tanhia Alvear. Biotechnologist. Universidad Tecnológica Metropolitana (In course)
- Carla Inostrosa. Biotechnologist. Universidad Tecnológica Metropolitana (In course)
- Claudio Martinez. Biotechnologist. Universidad Tecnológica Metropolitana (In course)

Posdoctoral students supervised in last 5 years
- Carola Maturana. PhD Program in Biological Sciences, Mention Physiological Sciences. Pontificia Universidad Católica de Chile. (2016)
- Gonzalo Gómes. PhD Program in Biological Sciences, Mention Physiological Sciences. Pontificia Universidad Católica de Chile. (2016-present)


Premios y Distinciones

  •   Herman Neimeyer Medal

    Chilean Society of Biochemistry and Molecular Biology

    Chile, 2009

    Best Ph.D. student in Biomedical Sciences of Chile

  •   Scientific career prize for PhD students

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2010

    Awarded with the “Scientific career prize for PhD students” as a recognition by the Biological Science Faculty of the Pontificia Universidad Católica de Chile (2010).

  •   Best PhD thesis

    Cell Biology Society of Chile

    Chile, 2010

    Awarded with the “Best PhD thesis” as a recognition by the Cell Biology Society of Chile (2010).

  •   best poster presentation in the International Gap Junction Conference 2011

    International Gap Junction Society

    Chile, 2011

    Awarded with the "best poster presentation in the International Gap Junction Conference 2011" performed in Ghents, Belgium (2011).

  •   Best PhD thesis

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2011

    Awarded with the “Best PhD thesis” as a recognition by the Chilean Academy of Sciences (2011).

  •   Matrícula de Honor

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2005

    Scholarship to the best biology student for the promotion

  •   Beca Juan Gomez Milla

    Chilean Ministry of Education

    Chile, 2001

    Scholarship to high score obtained in the National Academic Aptitude University Test, Chile

  •   PhD Fellowship.

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2006

    Scholarship as a recognition by CONICYT

  •   Thesis Support Fellowship for PhD student

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2007

    Scholarship as a recognition by CONICYT

  •   International Short Stay Grant for PhD student

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2007

    Scholarship as a recognition by CONICYT and Evaluation-orientation de la Coopération Scientifique (ECOS)

  •   International Short Stay Grant for PhD student

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2008

    Scholarship as a recognition by CONICYT

  •   Travel Grant for Attending Meetings.

    International Brain Organization

    Estados Unidos, 2008

    Travel grant to PhD students to attend neurosciences meeting

  •   International Postdoctoral Fellowship.

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2011

    Scholarship support as a recognition by Program Improvement of Quality and Equity in Education (MECESUP) PUC 0708.

  •   Travel stipend for Attending Meetings.

    International Gap Junction Comitee

    Estados Unidos, 2011

    Travel grant to Postdocs to attend the International Gap Junction Conference

  •   Travel Grant for Attending Meetings.

    International Brain Organization

    Chile, 2013

    Travel grant to Postdocs to attend neurosciences meeting

  •   Travel Grant for International Talks.

    International Society for Neurochemistry

    Chile, 2013

    Travel grant to young scientist to attend The International society Meeting

  •   Travel Grant for Attending Meetings.

    International Brain Organization

    Estados Unidos, 2015

    Scholarship for young scientists to attend Neuroscience meetings

  •   Travel stipend for Attending Meetings.

    European Glia Network

    España, 2015

    Travel stipend for Attending the The XII European Meeting on Glial Cell Function in Health and Disease

  •   International Short Stay Grant for Professors.

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2016

    International Short Stay Grant for Professors

  •   Miembro "Programa Ciencia de Frontera"

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2019

    El programa Ciencia de Frontera, tiene como objetivo reconocer la excelencia y potencialidad de científicos jóvenes en diferentes áreas de las ciencias y vincularlos a las actividades de la Academia


 

Article (51)

Editorial: Astrocytes, a Kaleidoscope of Diversities, a Pharmacological Horizon
HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function
Interferon-gamma and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage
Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage
Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species
Activation of Melanocortin-4 Receptor by a Synthetic Agonist Inhibits Ethanol-induced Neuroinflammation in Rats
Connexin 43 hemichannels and pannexin-1 channels contribute to the alpha-synuclein-induced dysfunction and death of astrocytes
Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease
The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment (vol 55, pg 4473, 2018)
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment.
Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function
Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization
Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword
The Neuroglial Dialog Between Cannabinoids and Hemichannels
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment
Cannabinoids Prevent the Amyloid beta-Induced Activation of Astroglial Hemichannels: A Neuroprotective Mechanism
New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis
Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions
Physiological Functions of Glial Cell Hemichannels
Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
Neuron-Glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis
Prenatal Exposure to Inflammatory Conditions Increases Cx43 and Panx1 Unopposed Channel Opening and Activation of Astrocytes in the Offspring Effect on Neuronal Survival
Restraint stress increases hemichannel activity in hippocampal glial cells and neurons
Excess cholesterol induces mouse egg activation and may cause female infertility
HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism
Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet
Role of Connexins and Pannexins in Ischemic Stroke
Role of connexins and pannexins in ischemic stroke.
Astrocytes Inhibit Nitric Oxide-Dependent Ca2+ Dynamics in Activated Microglia: Involvement of ATP Released Via Pannexin 1 Channels
Disruption in Connexin-Based Communication Is Associated with Intracellular Ca2+ Signal Alterations in Astrocytes from Niemann-Pick Type C Mice
Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation
Pannexin1 hemichannels are critical for HIV infection of human primary CD4(+) T lymphocytes
Connexin-based channels in astrocytes: How to study their properties
Glial hemichannels and their involvement in aging and neurodegenerative diseases
Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels
Modulation of interferon-gamma-induced glial cell activation by transforming growth factor beta 1: A role for STAT1 and MAPK pathways
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala
Amyloid beta-Induced Death in Neurons Involves Glial and Neuronal Hemichannels
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species
Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions
Hypoxia in High Glucose Followed by Reoxygenation in Normal Glucose Reduces the Viability of Cortical Astrocytes Through Increased Permeability of Connexin 43 Hemichannels
Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective
Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments
Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells
Currently used methods for identification and characterization of hemichannels
Chlorpromazine reduces the intercellular communication via gap junctions in mammalian cells
Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats
Chronic stress impairs acoustic conditioning more than visual conditioning in rats: Morphological and behavioural evidence

Abstract (7)

Prenatal exposure to inflammatory conditions increases hemichannel opening and activation of astrocytes in the offspring: repercussion on neuronal survival
Glutamate release through glial hemichannels: Focus on neuronal damage
HIV INFECTION OF ASTROCYTES INCREASED RELEASE OF DICKKOF-1 (DKK1) PROTEIN BY A HEMICHANNEL-DEPENDENT MECHANISM
SDF-1/CXCL12 induces migration of lymphocytes by a mechanism pannexin1 hemichannels dependent
HIV infection of astrocytes increases release of Dickkopf-1 protein by a gap junction and hemichannel dependent mechanism
SDF-1/CXCL12 induces migration of lymphocytes by a mechanism pannexin1 hemichannel dependent.
Human Platelets Express Functional Pannexin-1

BookSection (4)

Plasma membrane channels formed by connexins or pannexins in microglia: Possible role in the inflamed brain
Connexin based channels in astrocytes: how to study their properties
Role of Connexin Hemichannels in Neurodegeneration
Role of microglial activation in astroglial connexin expression and function leading to neurotoxicity

BookWhole (1)

SINGLE MEMBRANE CHANNELS FORMED BY CONNEXINS OR PANNEXINS: FOCUS ON THE NERVOUS SYSTEM

ConferencePoster (5)

Cannabinoids prevent the β-amyloid-induced hemichannel activity in neurons and glial cells
Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species.
Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels
Increased astroglial hemichannel activity induced by β-amyloid is associated with neuronal death in brain slices
Inhibition of Cx43 hemichannels prevents cortical astrocytes death induced by hypoxia in high glucose concentration

EditorialMaterial (1)

Editorial: Single membrane channels formed by connexins or pannexins: focus on the nervous system

Proyecto (17)

FONDECYT Regular 1210375 "Disentangling the role of hemichannels and pannexons on astroglial and neuronal dysfunction induced by heavy ethanol exposure"
FONDECYT Regular 1210940: Astrocytic cytokine signaling in multiple sclerosis: implications in disease progression
CENTRAL ROLE OF ASTROCYTES IN NEURONAL-DRIVEN REMYELINATION
CENTRAL ROLE OF ASTROCYTES IN NEURONAL-DRIVEN REMYELINATION
REDES 190187: Network for Accelerating Research in Synaptic Impairment of Neurodegenerative Diseases: Novel Signaling Mechanisms
ROLE OF MITOCHONDRIAL OXIDATIVE STRESS IN ABNORMAL SYNAPTIC TRANSMISSION INDUCED BY TRAUMATIC BRAIN INJURY=> A LOOK FROM THE PERSPECTIVE OF THE TRIPARTITE SYNAPSE
Anillo ACT1411 "Centro de investigación para el estudio de la conducta del consumo de alcohol en adolescentes: De la molécula a la función cerebral y el metabolismo periférico"
FONDECYT Regular: "Uncovering the role of hemichannels in glial and neuronal dysfunction induced by alpha-synuclein"
UNCOVERING THE ROLE OF HEMICHANNELS IN GLIAL AND NEURONAL DYSFUNCTION INDUCED BY ALPHA-SYNUCLEIN
Centro de investigación para el estudio de la conducta del consumo de alcohol en adolescentes=> De la molécula a la función cerebral y el metabolismo periférico
Papel y regulación de los hemicanales en las dinámicas de Ca2+ intracelular entre células dela granulosa y ovocitos de ratón
Role of astroglial cell hemichannels in prenatal LPS-induced neurotoxicity in the offspring
Role of astroglial cell hemichannels in prenatal LPS-induced neurotoxicity in the offspring
FONDECYT de Iniciación: "Role and regulation of glial cell hemichannels in maternal inflammation-induced brain dysfunction on the offspring"
Role and regulation of glial cell hemichannels in maternal inflammation-induced brain dysfunction on the offspring
PAPEL Y REGULACION DE LOS CANALES FORMADOS POR CONEXINA43 ASTROGLIAL EN LA DISFUNCION Y MUERTE CELULAR EN TEJIDO CEREBRAL IN VITRO INDUCIDA POR ISQUEMIA-REPERFUSION EN ALTA GLUCOSA.
CARACTERIZACION DE MECANISMOS MODULADORES DEL ESTADO FUNCIONAL DE HEMICANALES DE LAS UNIONES EN HENDIDURA EN CELULAS DEL SISTEMA NERVIOSO CENTRAL.

Review (11)

HEMICHANNELS: NEW PATHWAYS FOR GLIOTRANSMITTER RELEASE
Hemichannels: new roles in astroglial function
Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules
Connexin and pannexin hemichannels in inflammatory responses of glia and neurons
Glial connexin expression and function in the context of Alzheimer's disease
The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System
Understanding Risk Factors for Alzheimer's Disease: Interplay of Neuroinflammation, Connexin-based Communication and Oxidative Stress
Cell membrane permeabilization via connexin hemichannels in living and dying cells
Dysfunctions of the Diffusional Membrane Pathways Mediated Hemichannels in Inherited and Acquired Human Diseases
Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion
97
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

37
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

10
Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

7
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

7
Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Trinidad Montero

postdoctorate

Medicine

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

4
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

2
Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

2
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Nicole Salgado

Coordinador tecnico

Facultad de Ciencias Biologicas

Pontificia Universidad Católica de Chile

Santiago, Chile

2
vania figueroa

Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

2
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

2
HELMUTH SANCHEZ

INVESTIGADOR ADJUNTO

Laboratorio de Conexinas y Panexinas

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

VALPARAISO, Chile

2
Alexies Dagnino

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

1
Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

1
Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

1
Gonzalo Terreros

Assistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1
Gonzalo Gomez

Profesor Asistente

Instituto de Ciencias de la Saluda

Universidad Autónoma de Chile

Santiago, Chile

1
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

1
Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

1
Fernando Ortiz

profesor asistente

Universidad Autónoma de Chile

Santiago, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

1
Juan Montiel

Profesor Titular

FACULTAD DE MEDICINA

UNIVERSIDAD DIEGO PORTALES

Santiago, Chile

1
Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile