Man

Mauricio Antonio Retamal Lucero

Associate Professor

Universidad del Desarrollo

Santiago, Chile

Líneas de Investigación


Study of the molecular mechanisms of opening and closing of the channels formed by connexins. And the study of hemichannels in various cellular functions under physiological and pathological conditions.

Educación

  •  Bachelor of Science / Biology, UNIVERSIDAD DE CHILE. Chile, 2000
  •  PhD in Physiology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

  •   Associate Professsor Full Time

    Universidad del Desarrollo

    Medicina

    santiago, Chile

    2008 - A la fecha

Formación de Capital Humano


Postdoctoral Tutor training of Dr. Rodrigo Acuña. 2016-2020.
Tutor of PhD student. Ms Fernanda Rozas. 2016-present.
Tutor of PhD student Ms Viviana Orellana. 2017-present.
Tutor of PhD student Ms Ainoa Fernandez. 2019-present.

Classes in General Physiology for Medicine - UDD
Classes of Advanced Topics in Physiology - DICIM
Class on cellular communication in Biomedical Sciences - U. Autónoma
In all these courses, I have told students about connexins, hemichannels, cleft junctions, and lab results.


Difusión y Transferencia


In 2018, I participated in the science week of the Alianza Francesa school, Chamisero headquarters. On that occasion, during one morning I talked to kindergarteners about science and also did a series of basic experiments on chemistry and physics.
Also during 2018, I gave several interviews to electronic newspapers and radio and TV programs, about the role of Cx46 in diseases such as cancer.
https://m.elmostrador.cl/agenda-pais/vida-en-linea/vida-destacados/2019/01/10/estudio-podria-ayudar-adetener-metastasis-en-mujeres-con-cancer-de- mama / https://www.duna.cl/programa/aire-fresco/2019/01/10/programa-de-comunicacion-celular-en-cancer-udd-quebusca-mejorar-la-eficacia-de-los- current-treatments / http://biut.latercera.com/salud/2019/01/expertos-descubren-tratamiento-que-podria-disminuir-los-efectos-delcancer-de-mama/ https: //www.24horas. cl / videos / interviews24 / Chilean-study-could-help-stop-the-metastasis-of-breast-cancer-3058983 https://www.pauta.cl/ciencia-y-tecnologia/avanza-estudio-que -seeks-to-stop-metastasis-in-women-with-breast-cancer

- Also during 2018 and 2019 I participated in the Biology Study group 2 in ANID.

Finally, during the months of July and October 2019, with a group of 5 girls from Boston College La Farfana School in the Maipú commune, we did experiments in my laboratory on the effect of Chilote garlic and different types of paprika on the death of cancer cells in mom. They learned from cell culture to doing cell death experiments on a Nikon microscope. They found that a chilote garlic extract induces cell death even when the extract was highly diluted.



 

Article (59)

4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation.
Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats.
Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells
Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3).
Interferon-γ and High Glucose-Induced Opening of Cx43 Hemichannels Causes Endothelial Cell Dysfunction and Damage
Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?
Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease
Connexin and Pannexin-Based Channels in Oligodendrocytes=> Implications in Brain Health and Disease.
Cx46 hemichannel modulation by nitric oxide=> Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation.
Are Polyunsaturated Fatty Acids Implicated in Histaminergic Dysregulation in Bipolar Disorder?=> AN HYPOTHESIS.
Redox-mediated regulation of connexin proteins; focus on nitric oxide.
Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword
Topical Application of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive in Rats
Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity?
Contribution of peripheral and central chemoreceptors to sympatho-excitation in heart failure.
Regulation of Connexin-Based Channels by Fatty Acids.
Carbon Monoxide Modulates Connexin Function through a Lipid Peroxidation-Dependent Process=> A Hypothesis.
Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins.
Connexinopathies=> a structural and functional glimpse.
Extracellular Cysteine in Connexins: Role as Redox Sensors
Extracellular Cysteine in Connexins=> Role as Redox Sensors.
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness
Regulation of Connexins Expression Levels by MicroRNAs, an Update.
Regulation of gap junction channels and hemichannels by phosphorylation and redox changes=> a revision.
Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases.
Carbon monoxide: A new player in the redox regulation of connexin hemichannels.
Diseases associated with leaky hemichannels
Functional hemichannels formed by human connexin 26 expressed in bacteria
Neuron-Glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis
Carbon Monoxide (CO) Is a Novel Inhibitor of Connexin Hemichannels
Connexin and Pannexin hemichannels are regulated by redox potential
Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals.
Extracellular gentamicin reduces the activity of con nexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells
Hemichannels; from the molecule to the function
Opening of pannexin- and con nexin-based channels increases the excitability of nodose ganglion sensory neurons
Petrosal ganglion: a more complex role than originally imagined
ATP is required and advances cytokine-induced gap junction formation in microglia in vitro.
Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules.
Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation
Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca2+-dependent pathway
Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: Gap junctions versus hemichannels
Nitric oxide signaling in the retina: What have we learned in two decades?
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala
Biphasic effect of linoleic acid on connexin 46 hemichannels
Cell membrane permeabilization via connexin hemichannels in living and dying cells
FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity
Voltage-dependent facilitation of Cx46 hemichannels
Modulation of Cx46 hemichannels by nitric oxide
Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+](i) responses
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia
Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents
Connexin-based gap junction hemichannels: gating mechanisms
Dopamine inhibits ATP-induced responses in the cat petrosal ganglion in vitro
Gap junction hemichannels in astrocytes of the CNS
Adenosine triphosphate-induced peripheral nerve discharges generated from the cat petrosal ganglion in vitro

Abstract (5)

Linolenic and Linoleic Acid Induce the Opening of Connexin 43, 46 and 50 Hemichannel in Human Hela Cells
Purified Functional Human Connexin 26 Hemichannels Expressed in E. Coli
Is the Gain of Hemichannel Activity a Common Feature Shared by Cx26 Syndromic Deafness Mutants?
Hemichannels formed by connexin43 are sensitive to changes in cellular redox potential
Studies on putative gating mechanisms involved in opening Cx43 hemichannels in metabolically inhibited rat astrocytes

Errata (1)

Dopamine inhibits ATP-induced responses in the cat petrosal ganglion in vitro (vol 966, pg 283, 2003)

Proyecto (14)

CARBON MONOXIDE INHIBITS CX46 HCS THROUGH A LIPID PEROXIDATION-DEPENDENT PROCESS WHICH INCREASES CX46- CA2+ SENSITIVITY
Carbon monoxide inhibits Cx46 HCs through a lipid peroxidation-dependent process, which increases Cx46- Ca2+ sensitivity
CARDIORESPIRATORY IMBALANCE IN HIGHT-OUTPUT HEART FAILURE: DISTINCT ROLES FOR THE CENTRAL PRE-SYMPATHETIC NEURONS AND THE PERIPHERAL CAROTID CHEMORECEPTORS IN THE PROGRESSION OF THE DISEASE
CARDIORESPIRATORY IMBALANCE IN HIGHT-OUTPUT HEART FAILURE=> DISTINCT ROLES FOR THE CENTRAL PRE-SYMPATHETIC NEURONS AND THE PERIPHERAL CAROTID CHEMORECEPTORS IN THE PROGRESSION OF THE DISEASE
Estudio de vías de señalización intracelulares activadas por ácidos grasos omega-3 y sus efectos en el estado funcional de Hemicanales formados por Cxs del Cristalino
UNSATURATED FATTY ACIDS CHANGE CX43, CX46 AND CX50 HEMICHANNELS PROPERTIES INDUCING LENS CELLS DAMAGE.
Sensor de Voltaje de Canales de Iones=> Desde la Estructura a la Función
Unsaturated fatty acids change Cx43, Cx46 and Cx50 hemichannels properties inducing lens cells damage
NITRIC OXIDE INDUCES FUNCTIONAL AND STRUCTURAL MODIFICATIONS IN CX46 GAP-JUNCTION HEMICHANNELS AND CHANNELS.
NITRIC OXIDE INDUCES FUNCTIONAL AND STRUCTURAL MODIFICATIONS IN CX46 GAP-JUNCTION HEMICHANNELS AND CHANNELS.
PROGRAMA BECAS DE APOYO PARA LA REALIZACION DE TESIS DOCTORAL
Beca Doctorado - Conicyt
PROGRAMA NACIONAL DE BECAS DE POSTGRADO - DOCTORADO
Sensor de Voltage de Canales de Iones: Desde la Estructura a la Función

Review (8)

Are Polyunsaturated Fatty Acids Implicated in Histaminergic Dysregulation in Bipolar Disorder?: AN HYPOTHESIS
Carbon monoxide: A new player in the redox regulation of connexin hemichannels
Diseases associated with leaky hemichannels
Nitric oxide signaling in the retina: What have we learned in two decades?
Cell membrane permeabilization via connexin hemichannels in living and dying cells
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion
Connexin-based gap junction hemichannels: Gating mechanisms
Gap junction hemichannels in astrocytes of the CNS
65
Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

19
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

10
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Julio Alcayaga

Profesor Titular

Biología

UNIVERSIDAD DE CHILE, FAC. CIENCIAS, DEPTO. BIOLOGÍA

Santiago, Chile

6
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

4
vania figueroa

Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

3
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

3
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

2
Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

1
Carlos Manuel González

DIRECTOR ESCUELA

FACULTAD CIENCIAS DE LA VIDA

UNIVERSIDAD ANDRES BELLO

SANTIAGO, Chile

1
Carolina Oliva

Investigador Asociado

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Luis Leon

Director of Bioinformatics

R&D

Genoma Mayor SpA

Santiago, Chile

1
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
Ricardo Fernández

Associate Professor

Health

Universidad de Los Lagos

Osorno, Chile

1
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

1
César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

1
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Hugo Diaz

PhD

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Aníbal Vargas

Investigador postdoctoral

Universidad de O'Higgins

Rancagua, Chile

1
Fernando Ortiz

profesor asistente

Universidad Autónoma de Chile

Santiago, Chile

1
Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile