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Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Biophysics of ion channels; Protein-ligand interactions; Ion channels pharmacology; Molecular Modeling; Bioinformatics and Molecular Simulations

PhD in Sciences, Mention Plant Genetic Engineering, UNIVERSIDAD DE TALCA. Chile, 2010
Biologist, UNIVERSIDAD DE LA HABANA. Cuba, 2003
Specialist in Bioinformatics, Centro de Ingeniería Genética y Biotecnología (CIGB). Cuba, 2003

Teacher Full Time

UNIVERSIDAD DE TALCA

Ingeniería

Chile

2010 - 2011
Assistant Professor Full Time

UNIVERSIDAD DE TALCA

Ingeniería

Chile

2012 - 2014
Associate Professor Full Time

UNIVERSIDAD DE TALCA

Ingeniería

Chile

2014 - 2021
Full Professor Full Time

UNIVERSIDAD DE TALCA

Chile

2021 - A la fecha

Research Assistant Full Time

Centro Nacional de Bioinformática (BIOINFO)/Ministerio de Ciencia, Tecnología y Medio Ambiente

Cuba

2003 - 2004
Research Assistant Full Time

Centro de Estudios Científicos (CECs)

Chile

2004 - 2004
Research Assistant Full Time

Universidad de Talca

Chile

2004 - 2010
Researcher Full Time

CBSM/Utalca

Chile

2010 - 2012
Director of the Center for Bioinformatics and Molecular Simulations (CBSM) Full Time

CBSM/Utalca

Talca, Chile

2012 - A la fecha

Director of PhD. thesis: 4 in the last five years
Co-director of PhD. thesis: 1 in the last five years
Director of current PhD. thesis: 2 in the framework of the Fondecyt 1191133 Grant

Co-director of undergraduate thesis: 1
Director of undergraduate thesis: 4 in the last five years
Director of current undergraduate thesis: 1 in the framework of the Fondecyt 1191133 Grant

Dissemination: Every year I meet with secondary school students to motivate them to study Bioinformatics Engineering at University of Talca. I perform every year one talk of about 1 hour to this audience.
Transfer: One patent application

Fellowship for PhD. studies

CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

Chile, 2006

To perform graduate studies
Beca de Apoyo a la Realización de Tesis Doctoral # AT24071103

CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

Chile, 2007

Beca de Apoyo a la Realización de Tesis Doctoral
Fellowship for an international intership

CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

Chile, 2008

For a research stay at the University of Potsdam, Germany
Fellowship to finish PhD. thesis

CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

Chile, 2009

Beca de Término de Tesis Doctoral
Postdoctoral Fellowship

DEUTSCHE FORSCHUNGSGEMEINSCHAFT

Alemania, 2011

For a postdoctoral research at University of Potsdam, Germany
Young Scientist Fellowship

DESCONOCIDO

Reino Unido, 2012

Beca para participar en el 37 congreso de la Federación Europea de Sociedades de Bioquímica (FEBS) y el segundo congreso de la Unión Internacional de Bioquímica y Biología Molecular (IUBMB), Programa Científicos Jóvenes
Fellowship from Red Iberoamericana de Bioinformática

DESCONOCIDO

Brasil, 2003

For a research stay at "Instituto de Biofísica de la Universidad Federal de Río de Janeiro"


Characterization of a new molecule capable of inhibiting several steps of the amyloid cascade in Alzheimer's disease Peters, Christian; Burgos, Carlos F.; Aguilar, Luis Felipe; Aguayo, Luis G Article WOS Neurobiology of Disease (2020)
Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels Bustos, Daniel Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels Vandewege, Michael W; Zavala, Kattina; Brauchi, Sebastian E.; Opazo, Juan C. Article WOS Scientific Reports (2020)
KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis Lavanderos, Boris; Paz Saldias, Maria; Pulgar, Eduardo; Cruz, Pablo; Colombo, Alicia; Poblete, Horacio; Cerda, Oscar Article ISI FASEB JOURNAL (2020)
Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3 Cikutovi?-Molina, Rocio Article WOS Biomedicine & Pharmacotherapy (2020)
Zinc binding promotes greater hydrophobicity in Alzheimer's Aβ42 peptide than copper binding: Molecular dynamics and solvation thermodynamics studies Dinh Quoc Huy, Pham; Theodorakis, Panagiotis E.; Li, Mai Suan Article WOS Proteins: Structure, Function, and Bioinformatics (2020)
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels Schewe, M; Sun, H; Mert, U; Mackenzie, A; Pike, ACW; Vowinkel, KS; Conrad, LJ; Kiper, AK; Musinszki, M; Tegtmeier, M; et al. Article ISI SCOPUS SCIENCE (2019)
An extracellular cation coordination site influences ion conduction of OsHKT2;2 Riedelsberger J. Article ISI SCOPUS BMC PLANT BIOLOGY (2019)
Chalcone derivatives as non-canonical ligands of TRPV1 Bustos, Daniel; Zarraga, Miguel O.; Caballero, Julio; Brauchi, Sebastian Article ISI SCOPUS INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)
Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation Orellana V.P.; ArÃ©valo N.J.; Rojas C.G.; Arjona R.J.; AlcaÃno C.A.; Canan J.G.; Reuss L. Article ISI SCOPUS Nitric Oxide (2019)
Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening Concha, Guierdy; Prent-Penaloza, Luis; Caballero, Julio Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-PoreDomain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site Wiedmann F, Kiper AK, Bedoya M, Ratte A, Rinné S, Kraft M, Waibel M, Anad P, Wenzel W, González W, Katus HA, Decher N, Schmidt C Article SCOPUS Cellular Physiology and Biochemistry (2019)
Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
TASK Channels Pharmacology: New Challenges in Drug Design Article ISI SCOPUS JOURNAL OF MEDICINAL CHEMISTRY (2019)
TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines Cikutovic-Molina, Rocio; Herrada, Andres A.; Brown, Nelson Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
The molecular basis for an allosteric inhibition of K+-flux gating in K-2P channels Rinne, S; Kiper, AK; Bedoya, M; Aser, D; Gensler, I; Netter, MF; Stansfeld, PJ; Decher, N Article ISI SCOPUS ELIFE (2019)
Yeast strain Saccharomyces cerevisiae BYT45 lacking the cation extrusion systems ENA1-5 and NHA1 is suitable for the characterization of TASK-3 potassium channel antagonists Obando P.A. Article ISI SCOPUS FEMS YEAST RESEARCH (2019)
Computational Studies of Snake Venom Toxins Ojeda, Paola G.; Ramirez, David; Caballero, Julio Article ISI SCOPUS TOXINS (2018)
Folding and Lipid Composition Determine Membrane Interaction of the Disordered Protein COR15A Bremer, A; Ingolfsson, HI; Thalhammer, A; Hincha, DK Article ISI SCOPUS BIOPHYSICAL JOURNAL (2018)
Cloning and functional characterization of HKT1 and AKT1 genes of Fragaria spp.-Relationship to plant response to salt stress Véry, Anne-Aliénor; Sentenac, Hervé Article ISI SCOPUS JOURNAL OF PLANT PHYSIOLOGY (2017)
Commandeering Channel Voltage Sensors for Secretion, Cell Turgor, and Volume Control Karnik, Rucha; Waghmare, Sakharam; Zhang, Ben; Larson, Emily; Lefoulon, Cécile; Blatt, Michael R. Article ISI SCOPUS TRENDS IN PLANT SCIENCE (2017)
Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A(2), ApITx-I, purified from Agkistrodon piscivorus leucostoma snake venom Resende L.M.; Schezaro-Ramos R.; Collaço R.C.O.; Simioni L.R. Article ISI SCOPUS TOXICON (2017)
Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels Arévalo, Bárbara; Rinné, Susanne; Decher, Niels Article ISI SCOPUS MOLECULAR PHARMACEUTICS (2017)
Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia Decher, Niels; Ortiz?Bonnin, Beatriz; Friedrich, Corinna; Schewe, Marcus; Kiper, Aytug K; Rinné, Susanne; Seemann, Gunnar; Peyronnet, Rémi; Zumhagen, Sven; Kockskämper, Jens; et al. Article ISI SCOPUS EMBO MOLECULAR MEDICINE (2017)
Structure-Based Discovery of Potential Two-Pore-Domain Potassium Channel Task-3 (K 2P 9.1) Modulators Ramírez, David; Caballero, Julio; Zúñiga, Leandro; Arévalo, Bárbara; Kiper, Aytug; Rinne, Susanne; Decher, Niels; Gonzalez, Wendy Article Biophysical Journal. (2017)
CoaTx-II, a new dimeric Lys49 phospholipase A(2) from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological roles Almeida, J.R.; Lancellotti, M.; Soares, A.M.; Marangoni, S.; Da Silva, S.L. Article ISI SCOPUS TOXICON (2016)
Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels Goldstein M.; Rinne, S; Kiper, AK; Ramirez, D; Netter, MF; Bustos, D; Ortiz-Bonnin, B; Gonzalez, W; Decher, N Article ISI SCOPUS Scientific Reports (2016)
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness Dalamon V.; Fiori M.C.; Figueroa V.A.; Oliva C.A.; Del Rio R.; Gonzalez, W; Canan J.; Retamal M.A. Article ISI SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2016)
Gating, Regulation, and Structure in K-2P K+ Channels: In Varietate Concordia? Niemeyer, M. I. Article ISI SCOPUS Molecular Pharmacology (2016)
Molecular dynamics simulations and CD spectroscopy reveal hydration-induced unfolding of the intrinsically disordered LEA proteins COR15A and COR15B from Arabidopsis thaliana Navarro-Retamal, Carlos; Bremer, Anne; Hincha, Dirk K.; Thalhammer, Anja Article ISI SCOPUS PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2016)
Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea? Kiper, AK; Rinne, S; Rolfes, C; Ramirez, D; Seebohm, G.; Netter, MF; Gonzalez, W; Decher, N Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1 Mansour-Hendili, L; Blanchard, A.; Le Pottier, N; Roncelin, I; Lourdel S.; Treard, C; Gonzalez, W; Vergara-Jaque, A; Morin, G; Colin, E; et al. Article ISI SCOPUS Human Mutation (2015)
Outward Rectification of Voltage-Gated K+ Channels Evolved at Least Twice in Life History Riedelsberger J.; Dreyer, I; Gonzalez, W Article ISI SCOPUS PLOS ONE (2015)
Voltage-Sensor Transitions of the Inward-Rectifying K+ Channel KAT1 Indicate a Latching Mechanism Biased by Hydration within the Voltage Sensor Lefoulon, C.; Karnik, R.; Honsbein, A.; Gutla, P. V.; Grefen, C.; Riedelsberger J.; Poblete, T; Dreyer, I; Gonzalez, W Article ISI SCOPUS PLANT PHYSIOLOGY (2014)
An Extracellular Ion Pathway Plays a Central Role in the Cooperative Gating of a K-2P K+ Channel by Extracellular pH Gonzalez, W; Zuniga, L.; Cid, LP; Arevalo, B.; Niemeyer, MI; Sepulveda, FV Article ISI SCOPUS Journal of Biological Chemistry (2013)
The pH sensor of the plant K+-uptake channel KAT1 is built from a sensory cloud rather than from single key amino acids Gonzalez, W; Riedelsberger J.; Caballero, J; Dreyer, I Article ISI SCOPUS Biochemical Journal (2012)
Potassium (K plus ) gradients serve as a mobile energy source in plant vascular tissues Gajdanowicz, P; Michard, E; Sandmann M.; Rocha M.; Correa, LGG; Ramirez-Aguilar, SJ; Gomez-Porras, JL; Gonzalez, W; Thibaud, JB; van Dongen, JT; et al. Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2011)
The K + battery-regulating Arabidopsis K + channel AKT2 is under the control of multiple post-translational steps Sandmann, Michael; Sk?odowski, Kamil; Gajdanowicz, Pawel; Michard, Erwan; Rocha, Marcio; Gomez-Porras, Judith L.; Corrêa, Luiz Gustavo Guedes; Ramírez-Aguilar, Santiago J.; Cuin, Tracey Ann; van Dongen, Joost T.; et al. Article SCOPUS Plant Signaling and Behavior (2011)
A Minimal Cysteine Motif Required to Activate the SKOR K+ Channel of Arabidopsis by the Reactive Oxygen Species H2O2 Garcia-Mata, C; Wang, JW; Gajdanowicz, P; Gonzalez, W; Hills, A; Donald, N; Riedelsberger J.; Amtmann, A; Dreyer, I; Blatt, MR Article ISI SCOPUS Journal of Biological Chemistry (2010)
Distributed Structures Underlie Gating Differences between the K-in Channel KAT1 and the K-out Channel SKOR Riedelsberger J.; Sharma, T.; Gonzalez, W; Gajdanowicz, P; Morales-Navarro, SE; Garcia-Mata, C; Mueller-Roeber, B; Gonzalez-Nilo, FD; Blatt, MR; Dreyer, I Article ISI SCOPUS Molecular Plant (2010)
Distinct roles of the last transmembrane domain in controlling Arabidopsis K+ channel activity Gajdanowicz, P; Garcia-Mata, C; Gonzalez, W; Morales-Navarro, SE; Sharma, T.; Gonzalez-Nilo, FD; Gutowicz, J; Mueller-Roeber, B; Blatt, MR; Dreyer, I Article ISI SCOPUS NEW PHYTOLOGIST (2009)
Intrinsic electrostatic potential in the BK channel pore: Role in determining single channel conductance and block Carvacho I.; Gonzalez, W; Torres, YP; Brauchi, S.; Alvarez, O; Gonzalez-Nilo, FD; Latorre R. Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2008)
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel Niemeyer, MI; Gonzalez-Nilo, FD; Zuniga, L.; Gonzalez, W; Cid, LP; Sepulveda, FV Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Gating of two-pore domain K+ channels by extracellular pH Niemeyer, MI; Gonzalez-Nilo, FD; Zuniga, L.; Gonzalez, W; Cid, LP; Sepulveda, FV Article ISI SCOPUS BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
Effect of high concentration of Co (II) onEnterobacter liquefaciens strain C-1: A bacterium highly resistant to heavy metals with an unknown genome. Marrero, Jeannette; González, Luis Javier; Sánchez, Aniel; Ayala, Marta; Paz-Lago, Dalila; Fallarero, Adyary; Castellanos-Serra, Lila; Coto, Orquídea Article ISI PROTEOMICS (2004)


Evolutionary Variations in HLH Domain Modulate the Fast Inactivation Phase in Calcium Selective TRP Channels Aldama, LF; Bustos, D; Opazo, JG; Gonzalez, W Abstract ISI BIOPHYSICAL JOURNAL (2018)
Proton Permeation in Ci-Hv1 Voltage-Gated Proton Channels occurs through a Proton Wire Involving Residues D160 and D222 and It is Modulated by N264 Pupo, A; Baez-Nieto, D; Otárola E.; Yanez, O.; Vergara-Jaque, A; Gonzalez, W; Castillo, K; Contreras, G.; Larsson, HP; Latorre R.; et al. Abstract ISI BIOPHYSICAL JOURNAL (2015)
The pH sensor of the plant K plus uptake channel KAT1 is built from a sensory cloud rather than from single key amino acids Gonzalez, W; Riedelsberger J.; Morales-Navarro, SE; Caballero, J; Alzate-Morales, JH; Gonzalez-Nilo, FD; Dreyer, I Abstract ISI FEBS JOURNAL (2012)
Dissecting phosphatidylinositol 4,5-bisphosphate activation and thermosensation in TRP channels Orta, G; Salazar M.; Gonzalez, W; Mascayano, C; Raddatz, N; Rosenmann, E; Gonzalez-Nilo, F; Brauchi, S.; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2007)
External surface charge neutralization induces outward rectification on the calcium- and voltage-activated potassium channel BK Carvacho I.; Gonzalez, W; Orio, P; Brauchi, S.; Alvarez, O; Gonzalez-Nilo, FD; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2007)
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel. Gonzalez-Nilo, FD; Niemeyer, MI; Zuniga, L.; Gonzalez, W; Cid, PL; Sepulveda, FV Abstract ISI BIOPHYSICAL JOURNAL (2007)
Exploring the Shaker K+ channel S3b segment using deletion mutants. Gonzalez, C.; Rosenmann, E; Brauchi, S.; Gonzalez, W; Alvarez, O; González D; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2005)
Role of the electrostatic potential on the BK potassium channel conductance. Gonzalez-Nilo, FD; Gonzalez, W; Brauchi, S.; Orio, P; Carvacho I.; Rosenmann, E; Zaelzer, C; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2005)


COMPUESTOS INHIBIDORES DE CANALES DE POTASIO DE TIPO TASK (Solicitud de patente 201701280) Patent Patente asked to the National Institute of Industrial Property (INAPI)


Structural insights into the mechanism of multi-channel blockers of atrial ion channels Proyecto (2019)
Proyecto de postdoctorado “Identification of small molecules to inhibit the aggregation of Amyloid β peptides of Alzheimer’s Disease”. Proyecto W. González is the advisor (2018)
MODULATION OF GLYCINE RECEPTORS BY ? AUXILIARY SUBUNIT=> A CRITICAL TARGET FOR CENTRAL PAIN SENSITIZATION FONDECYT (3170690) Proyecto 2017-2020 Inv. Patrocinante
Núcleo Milenio de Enfermedades asociadas a Canales Iónicos (Minicad) Ministerio de Economía, Fomento y Turismo (Minicad) Proyecto 2017-2020 Coinvestigador(a)
Renovación del clúster de cómputo del Centro de Bioinformática y Simulación Molecular (CBSM ) de la Universidad de Talca FONDEQUIP (EQM160063) Proyecto 2016-2018 Director(a)
Discovery of novel disulfide-rich peptides in plants and animals=> applications in drug design for the treatment of pain FONDECYT (Postdoctor) Proyecto 2015-2018 Inv. Patrocinante
PYRAZOLOQUINOLINES DERIVATIVES=> SYNTHESIS AND BIOLOGICAL ACTIVITY FONDECYT (1150712) Proyecto 2015-2019 Coinvestigador(a)
STRUCTURAL AND FUNCTIONAL UNDERSTANDING OF ION CHANNELS OF THE ALMT (ALUMINUM ACTIVATED MALATE TRANSPORTER) FAMILY FONDECYT (1150054) Proyecto 2015-2019 Coinvestigador(a)
“Caracterización de Blancos Terapéuticos a Través de Herramientas Bioinformáticas=> Obtención de un Producto Líder y Oferta en Servicios de Consultoría” FONDEF (VIU140068) Proyecto 2015-2016 Inv. Patrocinante
BIOTRANSFORMATION PROCESSES CATALYZED BY LIGNINOLYTIC ENZYMES FROM PHANEROCHAETE CHRYSOSPORIUM=> RATIONAL PROTEIN DESIGN FROM COMPUTATIONAL CALCULATIONS AND SITE-DIRECTED MUTAGENESIS STUDIES FONDECYT (1140618) Proyecto 2014-2018 Coinvestigador(a)
Desarrollo y Evaluación Funcional de Moléculas Sintéticas Inhibidoras de los Canales de Potasio Task-3 para el Tratamiento de Tumores Sólidos FONDEF (CA13I10223) Proyecto 2014-2015 Coinvestigador(a)
Investigation of the selectivity and ion conduction mechanism of HKT Na+/K+ transporters FONDECYT (Postdoc) Proyecto 2014-2017 Inv. Patrocinante
UNDERSTANDING THE STRUCTURAL MECHANISM OF SELECTIVE BLOCKERS OF PH-GATED K2P CHANNELS FONDECYT (1140624) Proyecto 2014-2018 Inv. Responsable
INSIGHTS INTO THE STRUCTURAL BASIS OF THE INTERACTIONS BETWEEN CAMP-DEPENDENT PROTEIN KINASE (PKA) AND ITS SUBSTRATES. DEVELOPMENT OF PREDICTIVE MOLECULAR MODELS AND TESTING IN THE STUDY OF THE INTERACTIONS BETWEEN PKA AND POTASSIUM CHANNEL AKT2. FONDECYT (1130141) Proyecto 2013-2016 Coinvestigador(a)
Characterization of the modulation of TPK channels by signaling molecules PCI (2011-733) Proyecto 2012-2014 Director(a)
Molecular modelling of LEA proteins PCI (RED120019) Proyecto 2012-2013 Director(a)
Sensor de Voltaje de Canales de Iones=> Desde la Estructura a la Función PIA (ACT1104) Proyecto 2012-2015 Coinvestigador(a)
Rectification of voltage-gated plant K+ channels DFG, Alemania (DFG2011) Proyecto 2011-2012 Investigador(a)
REGULATION OF THE ACTIVITY OF TWO-PORE DOMAIN POTASSIUM CHANNELS BY DIFFERENT FACTORS FONDECYT (11100373) Proyecto 2010-2013 Inv. Responsable
NiaPoc- New interdisciplinary approaches to gain molecular insights into the regulation of potassium channels in plants PCI (2008 -141) Proyecto 2009-2011 Investigador(a)
PROGRAMA DE PASANTÍAS EN EL EXTRANJERO PARA BECARIOS DE DOCTORADO (2DO SEMESTRE) - 2007. Estadía de tres meses en la “Universidad de Potsdam, Grupo Dr. Ingo Dreyer" PFCHA (28070053) Proyecto 2008-2008 Investigador(a)
Caracterización del sensor de pH extracelular del canal de potasio KAT1. Su modulación durante la respuesta a estrés salino en Arabidopsis thaliana PAI (AT24071103) Proyecto 2007-2029 Inv. Responsable
ASPECTOS MOLECULARES QUE GOBIERNAN LA CONDUCTANCIA DE LOS CANALES DE POTASIO FONDECYT (1040254) Proyecto 2004-2006 Personal técnico y/o de apoyo
MECANISMO MOLECULAR DEL ACOPLAMIENTO ENTRE UN CANAL DE K+ ACTIVADO POR CA2+ (BKca) Y SUS SUBUNIDADES MODULADORES B. FONDECYT (1030830) Proyecto 2003-2007 Personal técnico y/o de apoyo
Combining computational and experimental approaches to enhance and perfect research on membrane transport proteins” Proyecto (0)


Exploring the fundamental role of potassium channels in novel model plants Review ISI SCOPUS JOURNAL OF EXPERIMENTAL BOTANY (2019)
Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (Ca-V) Channels Fissore, RA Review ISI SCOPUS MARINE DRUGS (2017)
K-2P channels in plants and animals González, Wendy; Valdebenito, Braulio; Caballero, Julio; Riadi, Gonzalo; Riedelsberger, Janin; Martínez, Gonzalo; Ramirez, David; Zúñiga, Leandro; Sepúlveda, Francisco V.; Dreyer, Ingo; et al. Review ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
TASK-2: a K-2p K+ channel with complex regulation and diverse physiological functions Cid, L. Pablo; Roa-Rojas, Hugo A.; Niemeyer, María I.; González, Wendy; Araki, Masatake; Araki, Kimi; Sepúlveda, Francisco V. Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2013)
ClC-5 mutations associated with Dent's disease: a major role of the dimer interface Lourdel S.; Grand, T; Burgos, J; Gonzalez, W; Sepulveda, F. V.; Teulon, J Review ISI SCOPUS Pflugers Archiv European Journal of Physiology (2012)

Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

Alicia Colombo

Profesora Asociada/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

Maria Niemeyer

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECS

Valdivia, Chile

Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

Carolina Mascayano

Académico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGIA

santiago, Chile

Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

Karen Castillo

Académica Investigadora

,Centro de Investigación de Estudios Avanzados del Maule (CIEAM)

Universidad Catolica del Maule

Talca, Chile

Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

Carolina Oliva

Investigadora y Coordinadora Áreas STEM

Vicerrectoría de Investigación y Doctorados

Universidad Autónoma de Chile

Santiago, Chile

Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Vania Figueroa

Directora InES Género y CTGénero, Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

Nelson Brown

Associate Professor

University of Talca

Talca, Chile

Mauricio Retamal

Associate Professor

Programa de Comunicación Celular en Cancer

Universidad del Desarrollo

Santiago, Chile

Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

IVAN GALLEGOS

PATHOLOGIST, LABORATORY DIRECTOR

PATHOLOGY

HOSPITAL CLINICO DE UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Paola Ojeda

Profesor Adjunto

Ciencias Pre-clinicas

Universidad Católica del Maule

Talca, Chile

Ariela Vergara

Associate Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

Andres Herrada

Principal Investigator

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Talca, Chile

Miguel Garriga

Assistant Professor

Plant Production

Universidad de Concepción

Chillán, Chile

Carlos Navarro

Chile

David Ramirez

Profesor Asistente

Facultad de Ciencias Biológicas

Universidad de Concepción

Concepcion, Chile

Bruna Benso

Profesora Asistente

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Samuel Morales

Académico Conferenciante

Universidad de Talca

Talca, Chile

Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

Janin Riedelsberger

Profesora Asistente

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

Daniel Bustos

Auxiliar Professor

Vicerrectoría de Investigación y Postgrado

Universidad Católica del Maule

Talca, Chile

Erix Hernández

Full Professor/Departamento de Medicina Traslacional, Académico-Investigador

Departamento de Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

Ingrid Carvacho

Assistant Professor

Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

Braulio Valdebenito

TALCA, Chile

Erwan Michard

Professor

ICB

Universidad de Talca

Talca, Chile

María Rubio

Investigador Postdoctoral

Facultad de Ingeniería

Universidad de Talca

Talca, Chile

Johanna Burgos

Postdoctoral

Biología

Centro de Estudios Científicos

Valdivia, Chile

Mauricio Bedoya

Profesor Auxiliar

CIEAM

Universidad Católica del Maule

Talca, Chile

Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile

Rodrigo Moraga

Postdoctoral researcher

Nuklear Medizin

Medizinische Hochschule Hannover

Hannover, Alemania

Wendy Gonzalez

Líneas de Investigación

Educación

PhD in Sciences, Mention Plant Genetic Engineering, UNIVERSIDAD DE TALCA. Chile, 2010

Biologist, UNIVERSIDAD DE LA HABANA. Cuba, 2003

Specialist in Bioinformatics, Centro de Ingeniería Genética y Biotecnología (CIGB). Cuba, 2003

Experiencia Académica

Teacher Full Time

Assistant Professor Full Time

Associate Professor Full Time

Full Professor Full Time

Experiencia Profesional

Research Assistant Full Time

Research Assistant Full Time

Research Assistant Full Time

Researcher Full Time

Director of the Center for Bioinformatics and Molecular Simulations (CBSM) Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Fellowship for PhD. studies

Beca de Apoyo a la Realización de Tesis Doctoral # AT24071103

Fellowship for an international intership

Fellowship to finish PhD. thesis

Postdoctoral Fellowship

Young Scientist Fellowship

Fellowship from Red Iberoamericana de Bioinformática

Article (45)

Abstract (8)

Patent (1)

Proyecto (25)

MODULATION OF GLYCINE RECEPTORS BY ? AUXILIARY SUBUNIT=> A CRITICAL TARGET FOR CENTRAL PAIN SENSITIZATION

Núcleo Milenio de Enfermedades asociadas a Canales Iónicos (Minicad)

Renovación del clúster de cómputo del Centro de Bioinformática y Simulación Molecular (CBSM ) de la Universidad de Talca

Discovery of novel disulfide-rich peptides in plants and animals=> applications in drug design for the treatment of pain

PYRAZOLOQUINOLINES DERIVATIVES=> SYNTHESIS AND BIOLOGICAL ACTIVITY

STRUCTURAL AND FUNCTIONAL UNDERSTANDING OF ION CHANNELS OF THE ALMT (ALUMINUM ACTIVATED MALATE TRANSPORTER) FAMILY

“Caracterización de Blancos Terapéuticos a Través de Herramientas Bioinformáticas=> Obtención de un Producto Líder y Oferta en Servicios de Consultoría”

BIOTRANSFORMATION PROCESSES CATALYZED BY LIGNINOLYTIC ENZYMES FROM PHANEROCHAETE CHRYSOSPORIUM=> RATIONAL PROTEIN DESIGN FROM COMPUTATIONAL CALCULATIONS AND SITE-DIRECTED MUTAGENESIS STUDIES

Desarrollo y Evaluación Funcional de Moléculas Sintéticas Inhibidoras de los Canales de Potasio Task-3 para el Tratamiento de Tumores Sólidos

Investigation of the selectivity and ion conduction mechanism of HKT Na+/K+ transporters

UNDERSTANDING THE STRUCTURAL MECHANISM OF SELECTIVE BLOCKERS OF PH-GATED K2P CHANNELS

INSIGHTS INTO THE STRUCTURAL BASIS OF THE INTERACTIONS BETWEEN CAMP-DEPENDENT PROTEIN KINASE (PKA) AND ITS SUBSTRATES. DEVELOPMENT OF PREDICTIVE MOLECULAR MODELS AND TESTING IN THE STUDY OF THE INTERACTIONS BETWEEN PKA AND POTASSIUM CHANNEL AKT2.

Characterization of the modulation of TPK channels by signaling molecules

Molecular modelling of LEA proteins

Sensor de Voltaje de Canales de Iones=> Desde la Estructura a la Función

Rectification of voltage-gated plant K+ channels

REGULATION OF THE ACTIVITY OF TWO-PORE DOMAIN POTASSIUM CHANNELS BY DIFFERENT FACTORS

NiaPoc- New interdisciplinary approaches to gain molecular insights into the regulation of potassium channels in plants

PROGRAMA DE PASANTÍAS EN EL EXTRANJERO PARA BECARIOS DE DOCTORADO (2DO SEMESTRE) - 2007. Estadía de tres meses en la “Universidad de Potsdam, Grupo Dr. Ingo Dreyer"

Caracterización del sensor de pH extracelular del canal de potasio KAT1. Su modulación durante la respuesta a estrés salino en Arabidopsis thaliana

ASPECTOS MOLECULARES QUE GOBIERNAN LA CONDUCTANCIA DE LOS CANALES DE POTASIO

MECANISMO MOLECULAR DEL ACOPLAMIENTO ENTRE UN CANAL DE K+ ACTIVADO POR CA2+ (BKca) Y SUS SUBUNIDADES MODULADORES B.

Review (5)