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Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Líneas de Investigación


Biophysics of potassium channels; Bioinformatics and Molecular Simulations; Molecular Modeling; Protein-ligand interactions

Educación

  •  PhD in Sciences, Mention Plant Genetic Engineering, UNIVERSIDAD DE TALCA. Chile, 2010
  •  Biologist, UNIVERSIDAD DE LA HABANA. Cuba, 2003
  •  Specialist in Bioinformatics, Centro de Ingeniería Genética y Biotecnología (CIGB). Cuba, 2003

Experiencia Académica

  •   Teacher Full Time

    UNIVERSIDAD DE TALCA

    Ingeniería

    Chile

    2010 - 2011

  •   Assistant Professor Full Time

    UNIVERSIDAD DE TALCA

    Ingeniería

    Chile

    2012 - 2014

  •   Associate Professor Full Time

    UNIVERSIDAD DE TALCA

    Ingeniería

    Chile

    2014 - A la fecha

Experiencia Profesional

  •   Research Assistant Full Time

    Centro Nacional de Bioinformática (BIOINFO)/Ministerio de Ciencia, Tecnología y Medio Ambiente

    Cuba

    2003 - 2004

  •   Research Assistant Full Time

    Centro de Estudios Científicos (CECs)

    Chile

    2004 - 2004

  •   Research Assistant Full Time

    Universidad de Talca

    Chile

    2004 - 2010

  •   Researcher Full Time

    CBSM/Utalca

    Chile

    2010 - 2012

  •   Director of the Center for Bioinformatics and Molecular Simulations (CBSM) Full Time

    CBSM/Utalca

    Talca, Chile

    2012 - A la fecha

Formación de Capital Humano


Director of PhD. thesis: 4 in the last five years
Co-director of PhD. thesis: 1 in the last five years
Director of current PhD. thesis: 2 in the framework of the Fondecyt 1191133 Grant

Co-director of undergraduate thesis: 1
Director of undergraduate thesis: 4 in the last five years
Director of current undergraduate thesis: 1 in the framework of the Fondecyt 1191133 Grant


Difusión y Transferencia


Dissemination: Every year I meet with secondary school students to motivate them to study Bioinformatics Engineering at University of Talca. I perform every year one talk of about 1 hour to this audience.
Transfer: One patent application


Premios y Distinciones

  •   Fellowship for PhD. studies

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2006

    To perform graduate studies

  •   Beca de Apoyo a la Realización de Tesis Doctoral # AT24071103

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2007

    Beca de Apoyo a la Realización de Tesis Doctoral

  •   Fellowship for an international intership

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2008

    For a research stay at the University of Potsdam, Germany

  •   Fellowship to finish PhD. thesis

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2009

    Beca de Término de Tesis Doctoral

  •   Postdoctoral Fellowship

    DEUTSCHE FORSCHUNGSGEMEINSCHAFT

    Alemania, 2011

    For a postdoctoral research at University of Potsdam, Germany

  •   Young Scientist Fellowship

    DESCONOCIDO

    Reino Unido, 2012

    Beca para participar en el 37 congreso de la Federación Europea de Sociedades de Bioquímica (FEBS) y el segundo congreso de la Unión Internacional de Bioquímica y Biología Molecular (IUBMB), Programa Científicos Jóvenes

  •   Fellowship from Red Iberoamericana de Bioinformática

    DESCONOCIDO

    Brasil, 2003

    For a research stay at "Instituto de Biofísica de la Universidad Federal de Río de Janeiro"


 

Article (45)

Characterization of a new molecule capable of inhibiting several steps of the amyloid cascade in Alzheimer's disease
Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels
Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels
KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis
Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3
Zinc binding promotes greater hydrophobicity in Alzheimer's Aβ42 peptide than copper binding: Molecular dynamics and solvation thermodynamics studies
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels
An extracellular cation coordination site influences ion conduction of OsHKT2;2
Chalcone derivatives as non-canonical ligands of TRPV1
Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation
Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening
Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-PoreDomain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site
Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine
TASK Channels Pharmacology: New Challenges in Drug Design
TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines
The molecular basis for an allosteric inhibition of K+-flux gating in K-2P channels
Yeast strain Saccharomyces cerevisiae BYT45 lacking the cation extrusion systems ENA1-5 and NHA1 is suitable for the characterization of TASK-3 potassium channel antagonists
Computational Studies of Snake Venom Toxins
Folding and Lipid Composition Determine Membrane Interaction of the Disordered Protein COR15A
Cloning and functional characterization of HKT1 and AKT1 genes of Fragaria spp.-Relationship to plant response to salt stress
Commandeering Channel Voltage Sensors for Secretion, Cell Turgor, and Volume Control
Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A(2), ApITx-I, purified from Agkistrodon piscivorus leucostoma snake venom
Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels
Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia
Structure-Based Discovery of Potential Two-Pore-Domain Potassium Channel Task-3 (K 2P 9.1) Modulators
CoaTx-II, a new dimeric Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological roles
Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness
Gating, Regulation, and Structure in K2P K+ Channels: In Varietate Concordia?
Molecular dynamics simulations and CD spectroscopy reveal hydration-induced unfolding of the intrinsically disordered LEA proteins COR15A and COR15B from Arabidopsis thaliana
Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?
Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1
Outward Rectification of Voltage-Gated K+ Channels Evolved at Least Twice in Life History
Voltage-Sensor Transitions of the Inward-Rectifying K+ Channel KAT1 Indicate a Latching Mechanism Biased by Hydration within the Voltage Sensor
An Extracellular Ion Pathway Plays a Central Role in the Cooperative Gating of a K-2P K+ Channel by Extracellular pH
The pH sensor of the plant K+-uptake channel KAT1 is built from a sensory cloud rather than from single key amino acids
Potassium (K plus ) gradients serve as a mobile energy source in plant vascular tissues
The K + battery-regulating Arabidopsis K + channel AKT2 is under the control of multiple post-translational steps
A Minimal Cysteine Motif Required to Activate the SKOR K+ Channel of Arabidopsis by the Reactive Oxygen Species H2O2
Distributed Structures Underlie Gating Differences between the K-in Channel KAT1 and the K-out Channel SKOR
Distinct roles of the last transmembrane domain in controlling Arabidopsis K+ channel activity
Intrinsic electrostatic potential in the BK channel pore: Role in determining single channel conductance and block
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel
Gating of two-pore domain K+ channels by extracellular pH
Effect of high concentration of Co (II) onEnterobacter liquefaciens strain C-1: A bacterium highly resistant to heavy metals with an unknown genome.

Abstract (8)

Evolutionary Variations in HLH Domain Modulate the Fast Inactivation Phase in Calcium Selective TRP Channels
Proton Permeation in Ci-Hv1 Voltage-Gated Proton Channels occurs through a Proton Wire Involving Residues D160 and D222 and It is Modulated by N264
The pH sensor of the plant K plus uptake channel KAT1 is built from a sensory cloud rather than from single key amino acids
Dissecting phosphatidylinositol 4,5-bisphosphate activation and thermosensation in TRP channels
External surface charge neutralization induces outward rectification on the calcium- and voltage-activated potassium channel BK
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel.
Exploring the Shaker K+ channel S3b segment using deletion mutants.
Role of the electrostatic potential on the BK potassium channel conductance.

Patent (1)

COMPUESTOS INHIBIDORES DE CANALES DE POTASIO DE TIPO TASK (Solicitud de patente 201701280)

Proyecto (25)

Structural insights into the mechanism of multi-channel blockers of atrial ion channels
Proyecto de postdoctorado “Identification of small molecules to inhibit the aggregation of Amyloid β peptides of Alzheimer’s Disease”.
MODULATION OF GLYCINE RECEPTORS BY ? AUXILIARY SUBUNIT=> A CRITICAL TARGET FOR CENTRAL PAIN SENSITIZATION
Núcleo Milenio de Enfermedades asociadas a Canales Iónicos (Minicad)
Renovación del clúster de cómputo del Centro de Bioinformática y Simulación Molecular (CBSM ) de la Universidad de Talca
Discovery of novel disulfide-rich peptides in plants and animals=> applications in drug design for the treatment of pain
PYRAZOLOQUINOLINES DERIVATIVES=> SYNTHESIS AND BIOLOGICAL ACTIVITY
STRUCTURAL AND FUNCTIONAL UNDERSTANDING OF ION CHANNELS OF THE ALMT (ALUMINUM ACTIVATED MALATE TRANSPORTER) FAMILY
“Caracterización de Blancos Terapéuticos a Través de Herramientas Bioinformáticas=> Obtención de un Producto Líder y Oferta en Servicios de Consultoría”
BIOTRANSFORMATION PROCESSES CATALYZED BY LIGNINOLYTIC ENZYMES FROM PHANEROCHAETE CHRYSOSPORIUM=> RATIONAL PROTEIN DESIGN FROM COMPUTATIONAL CALCULATIONS AND SITE-DIRECTED MUTAGENESIS STUDIES
Desarrollo y Evaluación Funcional de Moléculas Sintéticas Inhibidoras de los Canales de Potasio Task-3 para el Tratamiento de Tumores Sólidos
Investigation of the selectivity and ion conduction mechanism of HKT Na+/K+ transporters
UNDERSTANDING THE STRUCTURAL MECHANISM OF SELECTIVE BLOCKERS OF PH-GATED K2P CHANNELS
INSIGHTS INTO THE STRUCTURAL BASIS OF THE INTERACTIONS BETWEEN CAMP-DEPENDENT PROTEIN KINASE (PKA) AND ITS SUBSTRATES. DEVELOPMENT OF PREDICTIVE MOLECULAR MODELS AND TESTING IN THE STUDY OF THE INTERACTIONS BETWEEN PKA AND POTASSIUM CHANNEL AKT2.
Characterization of the modulation of TPK channels by signaling molecules
Molecular modelling of LEA proteins
Sensor de Voltaje de Canales de Iones=> Desde la Estructura a la Función
Rectification of voltage-gated plant K+ channels
REGULATION OF THE ACTIVITY OF TWO-PORE DOMAIN POTASSIUM CHANNELS BY DIFFERENT FACTORS
NiaPoc- New interdisciplinary approaches to gain molecular insights into the regulation of potassium channels in plants
PROGRAMA DE PASANTÍAS EN EL EXTRANJERO PARA BECARIOS DE DOCTORADO (2DO SEMESTRE) - 2007. Estadía de tres meses en la “Universidad de Potsdam, Grupo Dr. Ingo Dreyer"
Caracterización del sensor de pH extracelular del canal de potasio KAT1. Su modulación durante la respuesta a estrés salino en Arabidopsis thaliana
ASPECTOS MOLECULARES QUE GOBIERNAN LA CONDUCTANCIA DE LOS CANALES DE POTASIO
MECANISMO MOLECULAR DEL ACOPLAMIENTO ENTRE UN CANAL DE K+ ACTIVADO POR CA2+ (BKca) Y SUS SUBUNIDADES MODULADORES B.
Combining computational and experimental approaches to enhance and perfect research on membrane transport proteins”

Review (5)

Exploring the fundamental role of potassium channels in novel model plants
Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (Ca-V) Channels
K-2P channels in plants and animals
TASK-2: a K-2p K+ channel with complex regulation and diverse physiological functions
ClC-5 mutations associated with Dent's disease: a major role of the dimer interface
61
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

13
Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

12
David Ramirez

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

11
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

8
Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

8
Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

7
Daniel Bustos

Assistant Professor

Vicerrectoría de Investigación y Postgrado

Universidad Católica del Maule

Talca, Chile

7
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

6
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

5
Mauricio Bedoya

Research assistant

Ingeniería

Universidad de Talca

Talca, Chile

5
Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

5
Maria Niemeyer

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECS

Valdivia, Chile

3
Ariela Vergara

Assistant Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

3
Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

2
Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

2
Erwan Michard

Professor

ICB

Universidad de Talca

Talca, Chile

2
Ingrid Carvacho

Profesora Auxiliar/Directora de Investigación

Biología y Química

Universidad Católica del Maule

Talca, Chile

2
Erix Hernández

Academic

Laboratorio de Bioinformática y Química Computacional, Escuela de Química y Farmacia, Facultad de Medicina

Universidad Católica del Maule

Talca, Chile

1
Paola Ojeda

Profesor Adjunto

Ciencias Pre-clinicas

Universidad Católica del Maule

Talca, Chile

1
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

1
Johanna Burgos

Postdoctoral

Biología

Centro de Estudios Científicos

Valdivia, Chile

1
Nelson Brown

Associate Professor

University of Talca

Talca, Chile

1
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

1
Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

1
Monica Caceres

Profesor asistente

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
Braulio Valdebenito

.

.

.

TALCA, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Miguel Garriga

Assistant Professor

Plant Production

Universidad de Concepción

Chillán, Chile

1
Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

1
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carolina Oliva

Investigador Asociado

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
vania figueroa

Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

1
Karen Castillo

Investigadora

Laboratorio de Sensores Moleculares, Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso

Valparaiso, Chile

1
Carolina Mascayano

Académico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGIA

santiago, Chile

1
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Bruna Benso

Profesora Asistente

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
IVAN GALLEGOS

PATHOLOGIST, LABORATORY DIRECTOR

PATHOLOGY

HOSPITAL CLINICO DE UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

1
María Rubio

Investigador Postdoctoral

Facultad de Ingeniería

Universidad de Talca

Talca, Chile

1
Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile