Man

Nelson Enrique Brown Vega

Associate Professor

University of Talca

Talca, Chile

Líneas de Investigación


- Role of cyclin D-CDK4/6 enzymatic complexes in senescence and autophagy, using in vitro models of breast and gastric cancer. - Role of the senescence-associated secretory phenotype (SASP) in gastric tumorigenesis and platelet activity.

Educación

  •  Doctorado en Medicina, UNIVERSITY OF HEIDELBERG. Alemania, 2004
  •  Medicina, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
  •  Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE TALCA

    Talca, Chile

    2012 - 2014

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE TALCA

    Talca, Chile

    2015 - A la fecha

  •   Research Associate Full Time

    TUFTS UNIVERSITY

    Health Sciences

    Boston, Estados Unidos

    2004 - 2009

  •   Intructor in Medicine Full Time

    TUFTS UNIVERSITY

    Health Sciences

    Boston, Estados Unidos

    2009 - 2012

Experiencia Profesional

  •   Research Associate Full Time

    Tufts Medical Center / Tufts University

    Boston, Estados Unidos

    2004 - 2009

  •   Instructor in Medicine Full Time

    Tufts University

    Boston, Estados Unidos

    2009 - 2012

  •   Assistant Professor Full Time

    University of Talca

    Talca, Chile

    2012 - 2015

  •   Associate Professor Full Time

    University of Talca

    Talca, Chile

    2015 - A la fecha


 

Article (22)

mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
Endothelial transmigration of platelets depends on soluble factors released by activated endothelial cells and monocytes
Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro
Adenosine Derivates as Antioxidant Agents: Synthesis, Characterization, in Vitro Activity, and Theoretical Insights
SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines
Semisynthesis, Characterization and Evaluation of New Adenosine Derivatives as Antiproliferative Agents
TASK-3 Downregulation Triggers Cellular Senescence and Growth Inhibition in Breast Cancer Cell Lines
Palbociclib-induced autophagy and senescence in gastric cancer cells
The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis
CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T-cell acute lymphoblastic leukemia
Expression and cellular localization of HCN channels in rat cerebellar granule neurons.
Docking‘S Study Of 6-Substituted Adenosine-5'-N-Ethyluronamide Analogs As Selective Agonists At A3 Adenosine Receptor And Selection Of Compounds For To Be Synthesized Later
Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
}The selective cytotoxicity elicited by phytochemical extract from Senecio graveolens ( Asteraceae) on breast cancer cells is enhanced by hypoxia
Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary Epithelium
Cyclin D1 Kinase Activity Is Required for the Self-Renewal of Mammary Stem and Progenitor Cells that Are Targets of MMTV-ErbB2 Tumorigenesis
Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1(-/-) mice
The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development
A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic rats
Use of the tetracycline system for inducible protein synthesis in the kidney
Stimulation of the Sympathetic Perimesenteric Arterial Nerves Releases Neuropeptide Y Potentiating the Vasomotor Activity of Noradrenaline: Involvement of Neuropeptide Y-Y1 Receptors

Abstract (1)

Phytochemical extract from Senecio graveolens (Chachacoma): Searching new candidates for anti-cancer drugs

BookSection (2)

Cyclin D1, metabolism and the autophagy-senescence balance
Tumor Suppressor Genes

Proyecto (3)

Caracterización y validación de marcadores de autofagia como determinantes terapéuticos y de pronóstico en lesiones tempranas de cáncer gástrico en la población de Molina
THE ROLE OF CYCLIN D 1 ACTIVITY IN THE REGULATION OF AUTOPHAGY AND SENESCENCE IN MAMMARY AND GASTRIC EPHITELIAL CELLS
Desarrollo y evaluación funcional de moléculas sintéticas inhibidoras de los canales de potasio task-3 para el tratamiento de tumores sólidos

Review (1)

Adenosine: Synthetic methods of its derivatives and antitumor activity
25
Nelson Brown

Associate Professor

University of Talca

Talca, Chile

6
Claudio Valenzuela

CONFERENCIANTE

ESCUELA DE MEDICINA

Universidad de Talca

Talca, Chile

3
Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

2
Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

1
Susana Alfaro

Encargada de contenidos y soporte metodológico

Universidad de Tarapacá

Arica, Chile

1
Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

1
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

1
Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

1
Francisco Valdés

Docente

Instituto Inglés

Instituto Inglés-Departamento de Administración de Educación Municipal de Curicó

Curicó, Chile