Man

Cristian Osvaldo Salas Sanchez

Associate professor

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Líneas de Investigación


QUÍMICA DE HETEROCICLOS; QUÍMICA MEDICA; SÍNTESIS ORGÁNICA; DISEÑO Y SÍNTESIS DE COMPUESTOS CON PROPIEDADES BIOLÓGICAS

Educación

  •  Licenciado en Quimica, Universidad de Tarapaca. Chile, 1998
  •  Quimica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chemistry

    Santiago, Chile

    2005 - A la fecha

Experiencia Profesional

  •   Profesor Full Time

    Pontificia Universidad Catolica de Chile

    santiago, Chile

    2005 - A la fecha

Formación de Capital Humano


Number of Licenciatura/Bachillerato/Bachelor Thesis supervised: 10
Number of Doctorate/PhD Thesis supervised: 5

PhD Students
Pablo Thomas Riveros. Pontificia Universidad Católica de Chile. PhD in Chemistry. Tutor: Ricardo Tapia, Co-Tutor: Cristian Salas.
Ana Zarate. Pontificia Universidad Católica de Chile. PhD in Chemistry. Tutor: Cristian Salas.
Karina Vazuqez. Pontificia Universidad Católica de Chile. PhD in Chemistry. Tutor: Cristian Salas.
Natalia Quiñones I. Universidad de Valparaíso. Tutor: Mauricio Cuellar, Co-Tutor: Cristian Salas.
Marcos Mellado. Universidad de Valparaíso. Tutor: Mauricio Cuellar, Co-Tutor: Cristian Salas.



 

Article (34)

Hanschs analysis application to chalcone synthesis by Claisen-Schmidt reaction based in DFT methodology
Fluorescence properties of aurone derivatives: an experimental and theoretical study with some preliminary biological applications
New imidoyl-indazole platinum (II) complexes as potential anticancer agents: Synthesis, evaluation of cytotoxicity, cell death and experimental-theoretical DNA interaction studies
Nutritional composition, antioxidant activity and isolation of scopoletin from Senecio nutans: support of ancestral and new uses
Structural analysis and molecular docking of trypanocidal aryloxy-quinones in trypanothione and glutathione reductases: a comparison with biochemical data
New air stable cationic methallyl Ni complexes bearing imidoyl-indazole carboxylate ligand: Synthesis, characterization and their reactivity towards ethylene
Synthesis of new phosphorescent imidoyl-indazol and phosphine mixed ligand Cu(I) complexes structural characterization and photophysical properties
Gramicidin conformational changes during riboflavin photosensitized oxidation in solution and the effect of N-methylation of tryptophan residues
MULTI-INSTRUMENTAL CHARACTERIZATION OF TWO RED PIGMENTS IN FUNERARY ARCHAEOLOGICAL CONTEXTS FROM NORTHERN CHILE
New aryloxy-quinone derivatives as potential antiChagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis
Preliminary Studies on the Synthesis of (-)-Shikimic Acid Based 1,2,3,4-Tetrahydrobenzo[b]phenanthridine-7,12-diones
Synthesis and Pharmacophore Modelling of 2,6,9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines
Synthesis, Biological Evaluation, and Molecular Simulation of Chalcones and Aurones as Selective MAO-B Inhibitors
Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruzi
Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents
}The selective cytotoxicity elicited by phytochemical extract from Senecio graveolens ( Asteraceae) on breast cancer cells is enhanced by hypoxia
Efficient Indium-Mediated Dehalogenation of Aromatics in Ionic Liquid Media
Intramolecular Diels-Alder Furan-Mediated Synthesis of 8-Aryl-3,4-dihydroisoquinolin-1(2H)-ones, Convenient Precursors of Indeno[1,2,3-ij] iso-quinolines
New Short Strategy for the Synthesis of the Dibenz[b,f]oxepin Scaffold
Efficient indium-mediated dehalogenation of aromatics in ionic liquid media.
Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione
Studies on the Michael addition of naphthoquinones to sugar nitro olefins: first synthesis of polyhydroxylated hexahydro-11H-benzo[a]carbazole-5,6-diones and hexahydro-11bH-benzo[b]carbazole-6,11-diones
6,9-Dimethoxy-3,4-dihydro-1H-1,4-oxazino[4,3-a]indol-1-one
7-(tert-Butyldiphenylsilyloxy)-2,2-dimethyl-1-benzofuran-3(2H)-one
(Z)-Ethyl 2-phenyl-1-(2-vinylphenyl)vinylcarbamates. Part 1: Synthesis and preliminary studies on their divergent transformation into benzo[c]phenanthridines and 2-phenyl-1,4-naphthoquinones
Gold-Facilitated '6-Exo-dig' Intramolecular Cyclization of 2-[(2-Nitrophenyl)ethynyl]phenylacetic Acids: General Access to 5H-Benzo[b]carbazole-6,11-diones
(13)C NMR studies of heterocyclic naphtho- and anthraquinones. Deshielding effect on the carbonyl carbon with methyl substitution
Trypanosoma cruzi: Activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms
A convenient preparation of 7-bromo-2H-1,4-benzothiazine-3,5,8(4H)-trione and its application in the synthesis of the conaquinone B skeleton
Synthesis of 2-spironaphtho[2,3-b]pyranoquinones
Synthesis of dihydronaphthofurandiones and dihydrofuroquinolinediones with trypanocidal activity and analysis of their stereoelectronic properties
Synthesis and antiprotozoal activity of naphthofuranquinones and naphthothiophenequinones containing a fused thiazole ring
Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives
Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents

Abstract (4)

Metabolomic variation in Senecio graveolens (Asteraceae) in altitudinal populations
Phytochemical extract from Senecio graveolens (Chachacoma): Searching new candidates for anti-cancer drugs
Synthesis, evaluation, and docking of new 4-alkoxybenzyl bicyclic amine ethers as nicotinic acetylcholine receptor antagonists
Spectroelectrochemistry of 1,4-naphthoquinones and 5-nitroindazoles: Reduction mechanisms and free radical stability

Review (1)

Natural and Synthetic Naphthoquinones Active Against Trypanosoma Cruzi: An Initial Step Towards New Drugs for Chagas Disease
45
Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

9
Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Rene Rojas

Professor

Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

2
Nelson Brown

Associate Professor

University of Talca

Talca, Chile

2
Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

2
Mauricio Cuellar

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

2
Denis Fuentealba

PROFESOR ASOCIADO

QUIMICA FISICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Alejandro Toro

PROFESOR TITULAR

Química Física

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Alan Cabrera

Profesor Asistente

Departamento de Química Inorganica

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Flavia Zacconi

Associate Professor

Organic Chemistry

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Diego Cortés

Académico No Regular

Programa Institucional de Fomento a la Investigación, Desarrollo e Innovación

Universidad Tecnológica Metropolitana

Santiago, Chile

1
natalia quiñones

profesor ajdunto

UNIVERSIDAD DE VALPARAISO

Chile

1
EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Emilio Soto

Jefe de laboratorio

Centro de Investigaciones del Hombre en el Desierto (CIHDE)

Arica, Chile

1
JHON LÓPEZ

Assistant Professor

Química Orgánica

Universidad de Concepción

Concepción, Chile

1
Alejandro Madrid

Academico Asociado

Química

Universidad de Playa ancha

Valparaíso, Chile

1
CLAUDIO PARRA

Investigador Asociado

Dirección General de Investigación

UNIVERSIDAD DE TARAPACÁ

Arica, Chile

1
Ivan Martinez

Profesor Asociado

Ciencias Quimicas y Biologicas

UNIVERSIDAD BERNARDO O'HIGGINS

Santiago, Chile

1
MARIO SIMIRGIOTIS

Associate professor

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
PATRICIO LEYTON

Profesor Asociado

INSTITUTO DE QUÍMICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Bernardo Arriaza

Investigador

INSTITUTO DE ALTA INVESTIGACIÓN

Arica, Chile

1
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pablo Jaque

Profesor Asociado

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

1
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Susana Alfaro

Encargada de contenidos y soporte metodológico

Universidad de Tarapacá

Arica, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Marco Mellado

Investigador

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Raul Araya

Docente Investigador

Facultad de Ingenieria y Tecnologia

Universidad San Sebastián

Santiago, Chile

1
Marco Soto

Profesor Asociado

Química Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Iván González

Profesor

Universidad Central de Chile

Santiago, Chile

1
María José Torres

Docente

Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile