Man

Ricardo Alfredo Tapia Apati

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Heterocyclic Chemistry, Medicinal Chemistry, Organic Synthesis

Educación

  •  Organic Chemitry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1981
  •  Quimica Organica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1981

Experiencia Académica

  •   Full Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chemistry

    Santiago, Chile

    1971 - 2010

  •   Full Professor Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chemistry

    Santiago, Chile

    2017 - A la fecha

  •   Profesor Titular Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Quimica

    Santiago, Chile

    2011 - 2016

Experiencia Profesional

  •   Quimico Other

    CGM Nuclear

    Santiago, Chile

    2004 - 2005

Formación de Capital Humano


TEACHING: ADVANCED ORGANIC SYNTHESIS
PhD Theses Directed: CLAUDIO SAITZ BARRIA (PhD 1991); CARMINA QUINTANAR SANTIBAÑEZ (PhD 1994); MIRIAM GARATE VIDAL (PhD 1997); YOLANDA PRIETO LARA (PhD 2002); LUZ ALEGRIA AGUIRRE (PhD 2002); CRISTIAN SALAS SANCHEZ (PhD 2005); CLAUDIO LOPEZ ASTORGA (PhD 2005); LORENA CANTUARIAS BOTTERO (PhD 2009)
PhD Theses Co-Directed: CHRISTIAN ESPINOSA BUSTOS (PhD 2013); ANDREA CERDA MONJE (PhD 2013); MANUEL A. ESCOBAR (PhD 2014).
Current Graduate Students:
DAVID MORENO DA COSTA (2010- )
CLAUDIA LOPEZ LIRA (2012- )
PATRICIO SANCHEZ (2013- )
Postdoctoral Fellows: FRANCISCO ARMIJO (2008-2010); GONZALO RECABARREN (2008-2010) ALVARO CAÑETE (2008-2010); JORGE SOTO DELGADO (2013- )



 

Article (55)

An efficient and eco-friendly method for the thiol-Michael addition in aqueous solutions using amino acid ionic liquids (AAILs) as organocatalysts
Promising 2,6,9-trisubstituted purine derivatives for anticancer compounds: Synthesis, 3D-QSAR, and preliminary biological assays
Supercritical carbon dioxide solubility in hydrophobic ionic liquid mixtures: Experimental determination and thermodynamic modeling
Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3,6-disubstituted-1,2,4,5-tetrazine derivatives as potential antitumor agents
Thermal storage density of ionic liquid mixtures: A preliminary study as thermal fluid
Activation of Electrophile/Nucleophile Pair by a Nucleophilic and Electrophilic Solvation in a SNAr Reaction
Dual function of amino acid ionic liquids (Bmim[AA]) on the degradation of the organophosphorus pesticide, Paraoxon®
Effect of the nature of the nucleophile and solvent on an SNAr reaction
Synthesis and characterization of poly (ionic liquid) derivatives of N -alkyl quaternized poly(4-vinylpyridine)
Task-Specific Ionic Liquids as Extractants for the Solvent Extraction of Molybdenum(VI) from Aqueous Solution Using Different Commercial Ionic Liquids as Diluents
A New Approach to the Synthesis of Benzo[b]naphtho[2,3-b]furan-6,11-diones and 2-Benzyl-3-hydroxynaphthalene-1,4-diones
Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor
Mechanism for the SNAr reaction of atrazine with endogenous thiols: experimental and theoretical study
Structural analysis and molecular docking of trypanocidal aryloxy-quinones in trypanothione and glutathione reductases: a comparison with biochemical data
Multiscale Treatment for the Molecular Mechanism of a Diels−Alder Reaction in Solution: A QM/MM-MD Study
Gutmann’s Donor Numbers Correctly Assess the Effect of the Solvent on the Kinetics of SNAr Reactions in Ionic Liquids
Highly sensitive determination of vanadium (V) by catalytic adsorptive stripping voltammetry. Substituent effect on sensitivity III
N-Heterocyclic carbene copper(I) complex- catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles
Changes in the SNAr reaction mechanism brought about by preferential solvation
Design, Synthesis, Biological Evaluation and Binding Mode Modeling of Benzimidazole Derivatives Targeting the Cannabinoid Receptor Type 1
Lewis Acid Enhanced Ethene Dimerization and Alkene Isomerization-ESI-MS Identification of the Catalytically Active Pyridyldimethoxybenzimidazole Nickel(II) Hydride Species
Lewis Acid Enhanced Ethene Dimerization and Alkene IsomerizationESI-MS Identification of the Catalytically Active Pyridyldimethoxybenzimidazole Nickel(II) Hydride Species
New aryloxy-quinone derivatives as potential anti- Chagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis
New aryloxy-quinone derivatives as potential antiChagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis
Synthesis and pharmacophore modelling of 2,6,9-trisubstituted purine derivatives and their potential role as apoptosis-inducing agents in cancer cell lines
Synthesis and Pharmacophore Modelling of 2,6,9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines
2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities
Mechanistic pathways of aromatic nucleophilic substitution in conventional solvents and ionic liquids
Site activation effects promoted by intramolecular hydrogen bond interactions in SNAr reactions
Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents
Copper(I) complexes bases on a new indazol-4,7-dione ligand
Lewis Molecular Acidity of Ionic Liquids from Empirical Energy− Density Models
Mechanism of Pyrogallol Red Oxidation Induced by Free Radicals and Reactive Oxidant Species. A Kinetic and Spectroelectrochemistry Study
New Short Strategy for the Synthesis of the Dibenz[b,f]oxepin Scaffold
Novel 1-(1-benzyl-1H-indol-3-yl)-N,N,Ntrimethylmethanaminium iodides are competitive antagonists for the human a4b2 and a7 nicotinic acetylcholine receptors
Specific nucleophile–electrophile interactions in nucleophilic aromatic substitutions
Theoretical study on the molecular mechanism of the [5+2] vs. [4+2] cyclization mediated by Lewis acid in the quinone system
BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES
Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione
Solvent effects in ionic liquids: empirical linear energy-density relationships
Solvent effects in ionic liquids: empirical linear energy–density relationships
6,9-Dimethoxy-3,4-dihydro-1H-1,4-oxazino[4,3-a ]indol-1- one
Adsorption Behavior of Hydrophobically Modified Polyelectrolytes onto Amino- or Methyl-Terminated Surfaces
Electrochemistry behavior of endogenous thiols on fluorine doped tin oxide electrodes
NL MIND-BEST: A web server for ligands and proteins discovery-Theoretic-experimental study of proteins of Giardia lamblia and new compounds active against Plasmodium falciparum
Synthesis, characterization, and electrochemical studies of new 5-and 6-nitro N-acyl-1H-indazoles
(Z)-Ethyl 2-phenyl-1-(2-vinylphenyl)vinylcarbamates. Part 1: Synthesis and preliminary studies on their divergent transformation into benzo[c]phenanthridines and 2-phenyl-1,4-naphthoquinones
7-(tert -Butyldiphenylsilyloxy)-2,2-dimethyl-1-benzofuran- 3(2H)-one
Captopril electrochemical oxidation on fluorine-doped SnO2 electrodes and their determination in pharmaceutical preparations
Copper Bromide-Catalyzed C-Alkylation of 2-Amino-1,4-Naphthoquinone: New Synthesis of 1-Azaanthraquinones
New Approaches to 6-Oxoisoaporphine and Tetrahydroisoquinoline Derivatives
New approaches to 6-oxoisoaporphine and tetrahydroisoquinoline derivatives
New approaches to 6-oxoisoaporphine and tetrahydroisoquinoline derivatives
Gold-Facilitated '6-Exo-dig' Intramolecular Cyclization of 2-[(2-Nitrophenyl)ethynyl]phenylacetic Acids: General Access to 5H-Benzo[b]carbazole-6,11-diones
Microwave-Assisted Reaction of 2,3-Dichloronaphthoquinone with Aminopyridines

Proyecto (11)

BIO-BASED IONIC LIQUIDS AND SURFACE-ACTIVE BIO-BASED IONIC LIQUIDS AS REACTION MEDIA FOR DEGRADATION OF ORGANOPHOSPHORATED PESTICIDES
Design, synthesis and biological impact of new smooothened anatagonists as potent hedgehog signaling inhibitors in pancreatic cancer
DESIGN, SYNTHESIS AND BIOLOGICAL IMPACT OF NEW SMOOTHENED ANTAGONISTS AS POTENT HEDGEHOG SIGNALING INHIBITORS IN PANCREATIC CANCER
BENZIMIDAZOLEQUINONES AND BIOISOSTERES AS ANTI-CHAGASIC AGENT: TRYPANOCIDAL EFFECT, SELECTIVITY AND 3D-QSAR STUDIES
BENZIMIDAZOLEQUINONES AND BIOISOSTERES AS ANTI-CHAGASIC AGENT=> TRYPANOCIDAL EFFECT, SELECTIVITY AND 3D-QSAR STUDIES
Nucleo Milenio. Renovación Centro de Investigación en Líquidos Iónicos Santiago=> CILIS
DESIGN AND SYNTHESIS OF SMALL MOLECULES WITH POTENTIAL OSTEOGENESIS-INDUCING ACTIVITY IN MESENCHYMAL STEM CELLS. A CHEMICAL APROACH TO BONE REGENERATIVE MEDICINE.
THEORETICAL STUDY OF THE HETERO-DIELS-ALDER REACTIONS IN DIFFERENT REACTIONS MEDIA
Nucleo Milenio. Centro de Investigación en Líquidos Iónicos Santiago=> CILIS
ESTUDIO DE OBTENCION DE QUINONAS POLICICLICAS DERIVADAS DE BENZOTHIAZINO- Y PIRIDOINDOLOQUINONAS.
SINTESIS Y ACTIVIDAD ANTITUMORAL DE QUINONAS ANGULARES N-HETEROCICLICAS.

Review (1)

Natural and Synthetic Naphthoquinones Active Against Trypanosoma Cruzi: An Initial Step Towards New Drugs for Chagas Disease
56
Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

12
Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

8
Renato Contreras

professor

Quimica

Universidad de Chile

Santiago, Chile

7
Paola Campodonico

Director of Centro de Química Médica and Associate Professor

CENTRE OF MEDICINAL CHEMISTRY, FACULTY OF MEDICINE, UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

4
Marcela Urzúa

Associate Professor

Chemistry

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

3
Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

3
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Javier Romero

Profesor Asistente

Departamento de Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

3
Ximena Briones

UNIVERSIDAD DEL DESARROLLO

SANTIAGO, Chile

3
Maria Encinas

Full Professor

Enviroment Science

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

2
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

2
JORGE PAVEZ

Professor

Materials Chemistry

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Juan Armijo

Asociado

Inorgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

2
ANA ZÁRATE

investigadora

Químca-Física

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Mehrdad Yazdani-Pedram

Académico Profesor Titular

Organic and Physical Chemistry

Universidad de Chile

Santiago, Chile

2
CHRISTIAN ESPINOSA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

2
Rodrigo del Rio

associate professor

inorganic chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FACULTAD DE QUIMICA, DPTO QUIMICA INORGANICA

santiago, Chile

2
Rene Rojas

Professor

Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Alan Cabrera

Profesor Asistente

Departamento de Química Inorganica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Elias Atala

Project Manager

Naturex- Chile botanics division

Santiago, Chile

1
Christian Espinosa

Postdoctorando

Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
HERNAN PESSOA

Profesor Asociado

Química Orgánica y Fisicoquímica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Fabiane Manke

Académico Docente Investigador

Universidad Autónoma de Chile

Talca, Chile

1
Sebastian Gallardo

Profesor colaborador

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Veronica Arancibia

Profesor horas

Quimica Inorganica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Bárbara Rodríguez

Académica/Investigadora

Centro de Investigación en Recursos Naturales y Sustentabilidad

Universidad Bernardo O'Higgins

Santiago, Chile

1
Camilo López

prof. Asociado

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Maria Soledad Ureta

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Hernan Speisky

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

1
Claudia Mardones

Académica

Departamento Análisis Instrumental

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Carola Vergara

Profesor Asociado

Departamento de Análisis Instrumental

Universidad de Concepción

Concepcion, Chile

1
Juan Guerrero

ACADEMICO

QUÍMICA DE LOS MATERILAES

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
cristian calderon

inestigador/profesor

Centro de Química Medica

Universidad del Desarollo

Santiago, Chile

1
Julio Urzúa

Investigador

Materiales Avanzados

Comisión Chilena de Energía Nuclear

Santiago, Chile

1
Carlos Rojas

Profesor Asistente

Departamento de Química

Universidad de Chile

Santiago, Chile

1
Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
María José Torres

Docente

Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Daniela Millan

Academico investigador

Centro integrativo de biologia y quimica aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

1
Claudia López

Investigador Asociado

Food Science and Technology

The Ohio State University

Columbus, Estados Unidos

1
MONICA ANTILEN

Profesor Asociado

quimica Inorganica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Raul Araya

Docente Investigador

Facultad de Ingenieria y Tecnologia

Universidad San Sebastián

Santiago, Chile

1
Manuel Gacitúa

Profesor asistente

Departamento de Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

1
Gonzalo Recabarren

Académico

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Javiera Morales

Académica / Coordinadora de Investigación

Facultad de ciencias de la salud

Universidad Bernardo O'Higgins

Santiago, Chile