Man

Paola Rossana Campodonico Galdames

Director of Centro de Química Médica and Associate Professor

CENTRE OF MEDICINAL CHEMISTRY, FACULTY OF MEDICINE, UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Líneas de Investigación


Solvent Effects; kinetic and reaction mechanism; reactivity in organic systems based on quantum mechanic methods; Catalysis and pharmacological studies in ionic liquids and deep eutectic solvents. Diseño y síntesis de nuevas móleculas activas.

Educación

  •  Doctor in science with mention in Chemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
  •  Chemist, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 1996
  •  Chemist, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 1996
  •  DIPLOMADO EN EDUCACIÓN CLÍNICA, UNIVERSIDAD DEL DESARROLLO. Chile, 2020

Experiencia Académica

  •   Associate Professor Full Time

    Universidad del Desarrollo

    Faculty of Medicine

    Santiago, Chile

    2006 - A la fecha

  •   Academic Staff of the PhD Program in Chemistry Other

    UNIVERSIDAD DE CHILE

    Faculty of Science

    Santiago, Chile

    2010 - A la fecha

  •   Associate research Part Time

    Interdisciplinary Centre of Ionic Liquids. P10-003F

    Santiago, Chile

    2010 - 2017

  •   Director of Centre of Medicinal Chemistry Full Time

    Universidad del Desarrollo

    Medicine

    Santiago, Chile

    2014 - A la fecha

  •   Staff of PhD program named PhD in Science and Innovation on Medicine Full Time

    Universidad del Desarrollo

    Medicine

    Santiago, Chile

    2014 - A la fecha

  •   DIRECTORA Other

    FONDEF

    MEDICINA

    SANTIAGO, Chile

    2022 - A la fecha

Experiencia Profesional

  •   ASSOCIATE PROFESSOR Full Time

    Universidad del Desarrollo

    Santiago, Chile

    2006 - A la fecha

  •   ASSISTANT PROFESSOR Part Time

    Universidad del Desarrollo

    Santiago, Chile

    2004 - 2006

  •   DIRECTOR OF CENTRE OF MEDICINAL CHEMISTRY Full Time

    Universidad del Desarrollo

    Santiago, Chile

    2014 - A la fecha

  •   ASSISTANT PROFESSOR Part Time

    Universidad Mayor

    Santiago, Chile

    1996 - 2000

Formación de Capital Humano


Postdoctoral fellows:
• (2011-2014) Marcela Gazitúa PhD.
Postdoctoral Project Fondecyt # 3120060.
Clínica Alemana-Universidad del Desarrollo.
Competition on Nucleophilic Aromatic Substitution Reactions mediated by the solvent. Experimental and Theoretical Studies.

• (2014) Ximena Briones PhD.
Postdoctoral Fellow from Millenium Scientific Iniciative. CILIS.
Synthesis and Caracterization of poly(ionic liquids)

• (2014). Karla Calfuman PhD.
Postdoctoral Fellow from Millenium Scientific Iniciative. CILIS.
Ka determination in ionic liquids and bynary mixtures of them.

• (2015). Cristian Calderón PhD.
Postdoctoral Fellow from Millenium Scientific Iniciative. CILIS.
Enzymatic Reactions in Ionic Liquids.

• (2014 – 2017) Ximena Briones PhD.
Postdoctoral Project Fondecyt #
Synthesis and Characterization of poli(ionic liquids)

• (2014 – 2019) Marcela Gazitúa PhD.
Postdoctoral Project from ICIM-UDD.
RESOLUTION OF RACEMIC PHARMACEUTICAL COMPOUNDS USING SUPPORTED LIQUID MEMBRANES BASED ON IONIC LIQUIDS

• (2016 – 2019) Cristian Calderón PhD.
Postdoctoral Project from ICIM-UDD.
Drug delivery from Deep Eutectic Solevnts.

• (2017 – 2018) Fabian Martínez PhD.
Postdoctoral Project from ICIM-UDD.
Extraction and characterization of natural bioactive compounds from Chilean plants.

• (2020) Dr. Cristian Suarez PhD.
Postdoctoral fellow from UDD.
SÍNTESIS Y CARACTERIZACIÓN DE NUEVOS DERIVADOS O-ARILADOS DE 1-AZABENZANTRONA DIRIGIDOS A MITOCONDRIA COMO AGENTES QUIMIOTERAPÉUTICOS EN MODELOS AGRESIVOS DE CÁNCER HUMANO: EVALUACIÓN CITOTÓXICA Y ANTIMETASTÁSICA IN VITRO.

• (2022-2024) Dr. Cristian Suarez PhD.
Postdoctoral Project Fondecyt # 3220509
SÍNTESIS DE CATIONES LIPOFILICOS DESLOCALIZADOS DERIVADOS DE 1-AZABENZANTRONA COMO AGENTES QUIMIOTERAPÉUTICOS EN MODELOS AGRESIVOS DE CÁNCER HUMANO: EVALUACIÓN CITOTÓXICA Y ANTIMETASTÁSICA IN VITRO.

• (2022) Dr. Jackson Alcazar PhD.
Postdoctoral fellow from UDD.
DISEÑO RACIONAL MEDIANTE RELACIONES ESTRUCTURA-ACTIVIDAD Y POSTERIOR SÍNTESIS DE AZA-BODIPYS CON POTENCIALES PROPIEDADES FOTODINÁMICAS PARA EL TRATAMIENTO DE CÁNCER.

Graduate Students:
• (2010-2013) Rodrigo Ormazábal Toledo PhD.
University of Chile
KINETICS AND MECHANISTIC STUDY ON AROMATIC NUCLEOPHILIC SUBSTITUTION REACTIONS IN IONIC LIQUIDS AND MOLECULAR SOLVENT: EXPERIMENTAL AND THEORETICAL STUDIES.

• (2013 – 2017) Jazmín Alarcón PhD.
University of Chile.
Solvent Effect studies on Nucleophilic Aromatic Substitution Reactions in medias of different polarities.

• (2016 – up to date ) Bachelor Bruno Sanchez.
University of Chile
Solvent Effects on medias of different polarities.

(2018 – up to date) Bachelor Belén Olivares
University of Cuyo, Argentina.
NATURAL DEEP EUTECTIC SOLVENTS FORMULATED TO STABILIZE BETA-LACTAM ANTIBIOTIC.

Undergraduate Students
• (2009) Rodrigo Ormazábal Toledo.
Faculty of Science from University of Chile
KINETICS AND MECHANISTIC STUDY ON AROMATIC NUCLEOPHILIC SUBSTITUTION REACTIONS.

• (2011) Sebastian Gallardo Fuentes.
Faculty of Science from University of Chile
KINETICS AND MECHANISTIC STUDY ON AROMATIC NUCLEOPHILIC SUBSTITUTION REACTIONS ON HETEROCICLIC SYSTEMS: EXPERIMENTAL AND THEORETICAL STUDIES.

• (2012) Jazmín Alarcón Esposito.
Faculty of Science from University of Chile
KINETICS AND MECHANISTIC STUDY ON AROMATIC NUCLEOPHILIC SUBSTITUTION REACTIONS WITH BIOTHIOLS.

• (2013) Constanza Garrido.
Faculty of Science from University of Chile
Experimental study on nucleophilic aromatic substitution reactions in binary mixtures of solvents.

• (2013) Karen González.
Faculty of Science from University of Chile
Experimental study on nucleophilic aromatic substitution reactions using oximes like nucleophiles.

• (2014) Rayen Polo.
Faculty of Science from University of Chile
Extraction of c-ficocianine with ionic liquids and binary mixtures of them.

• (2016) Bruno Sanchez.
Faculty of Science from University of Chile
Kinetic studies of quinazoline derivatives on solvents of varying polarities.

• (2017) Camila Moreno.
Faculty of Science from University of Chile
Fluorescence Studies on Ionic Liquids.

Proyectos Adjudicados y en Curso

PARTICIPACIÓN EN PROYECTOS DE INVESTIGACIÓN
ANID - FONDECYT
2017 – 2022 EFFECT OF AVOCADO BASED MEDITERRANEAN DIET ON SERUM LIPIDS FOR SECONDARY PREVENTION AFTER ISCHEMIC STROKE.
Co-Investigador
Proyecto Fondecyt Regular # 1181333
Universidad del Desarrollo-Clínica Alemana

2015 – 2019 EXPERIMENTAL & THEORETICAL STUDIES ON NUCLEOPHILIC SUBSTITUTION REACTIONS IN SOLVENTS OF VARYING POLARITY.
Investigador Responsable
Proyecto Fondecyt Regular # 1150759
Clínica Alemana-Universidad del Desarrollo

2010-2014 KINETICS AND MECHANISTIC STUDY ON AROMATIC NUCLEOPHILIC SUBSTITUTION REACTIONS IN IONIC LIQUIDS AND MOLECULAR SOLVENT: EXPERIMENTAL AND THEORETICAL STUDIES.
Investigador Responsable
Proyecto Fondecyt Regular # 1100492
Clínica Alemana-Universidad del Desarrollo

2009-2012 AMINOLISYS OF DITHIOCARBONATES. KINETICS, MECHANISMS AND SOLVENT EFFECTS.
Co-Investigador
Proyecto Fondecyt Regular # 1095145
Pontificia Universidad Católica de Chile
Clínica Alemana-Universidad del Desarrollo

2007-2008 DESARROLLO DE ESCALAS TEÓRICAS DE ELECTROFILIA/NUCLEOFILIA EN ACEPTORES DE MICHAEL Y SEGMENTOS DE ADN Y SU APLICACIÓN AL DISEÑO DE DROGAS ANTITUMORALES.
Investigador Responsable
Proyecto Fondecyt de Cooperación Internacional # 7070053
Profesor Visitante: Dr. Juan Andrés Bort
Universidad Jaume I, Castellón de la Plana – España.
Clínica Alemana - Universidad del Desarrollo

2006-2009 DESARROLLO DE ESCALAS TEÓRICAS DE ELECTROFILIA/NUCLEOFILIA EN ACEPTORES DE MICHAEL Y SEGMENTOS DE ADN Y SU APLICACIÓN AL DISEÑO DE DROGAS ANTITUMORALES.
Investigador Responsable
Proyecto Fondecyt de Iniciación # 11060195
Clínica Alemana - Universidad del Desarrollo

2004-2006 IMPLEMENTACIÓN DE DIAGRAMAS ENERGIA-COORDENADA DE REACCION PARA EL ESTUDIO DE MECANISMOS DE REACCION EN QUÍMICA ORGÁNICA. APLICACIÓN AL ESTUDIO DE REACCIONES DE SUSTITUCION NUCLEOFILICA.
Investigador Responsable
Proyecto Fondecyt Post-Doctoral # 3040081
Universidad de Chile

2001-2004 CINÉTICA Y MECANISMOS DE REACCIÓN DE ARIL CARBONATOS Y ARIL CLOROFORMIATOS CON PIRIDINAS. ESTUDIO EXPERIMENTAL Y TEÓRICO
Investigador Responsable
Proyecto Fondecyt para Estudiantes de Doctorado # 2010081
Pontificia Universidad Católica de Chile

ANID FONDEF
2022 – 2024 NUEVA FORMULACIÓN PARA LA LIMPIEZA Y DESBRIDAJE EN LA CURACIÓN DE HERIDAS Y ÚLCERAS CUTÁNEAS.
ID21I10053
Directora
UDD-PUC

INICIATIVA CIENTÍFICA MILENIO
2015 – 2019 CENTRO INTERDISCIPLINARIO DE LÍQUIDOS IÓNICOS (CILIS). Renovación
Investigador Asociado
División Cinética y Mecanismos de Reacción
Proyecto P10-003
Iniciativa Científica Milenio
Universidad de Chile-Pontificia Universidad Católica de Chile.

2011-2014 CENTRO INTERDISCIPLINARIO DE LÍQUIDOS IÓNICOS (CILIS)
Investigador Asociado
División Cinética y Mecanismos de Reacción
Proyecto P10-003
Iniciativa Científica Milenio
Universidad de Chile-Pontificia Universidad Católica de Chile.

PROYECTOS DE INVESTIGACIÓN INTERNOS UDD
DIRECCIÓN DE TRANSFERENCIA TECNOLÓGICA iCONO UDD
2021 a la fecha
PROGRAMA DE APOYO AL DESARROLLO TECNOLÓGICO
DISEÑO, SÍNTESIS Y OPTIMIZACIÓN DE MOLÉCULAS CON ACTIVIDAD ANTINEOPLÁSICA Y SU POSTERIOR EVALUACIÓN BIOLÓGICA. ANÁLISIS E INTERPRETACIÓN DE RESULTADOS QUÍMICOS Y BIOLÓGICOS.
Investigador Responsable. Dr. Cristian Suárez
Co-Investigador. Dra. Paola Campodónico

2021 a la fecha
FONDOS EXTRAORDINARIOS ICIM
SÍNTESIS Y CARACTERIZACIÓN DE MOLÉCULAS PEQUEÑAS ELECTROFÍCAS COMO AGENTES QUIMIOTERAPÉUTICOS EN MODELOS AGRESIVOS DE CÁNCER HUMANO.
Investigador Responsable. Dr. Cristian Suárez
Co-Investigador. Dra. Paola Campodónico
ICIM-UDD

FACULTAD DE MEDICINA
2010-2011 ESTUDIO CINETICO Y MECANISTICO EN REACCIONES DE SUSTITUCION AROMATICAS EN LIQUIDOS IONICOS. ESTUDIO EXPERIMENTAL Y TEORICO.
Investigador Responsable
Centro de Gestión # 23.400.026
Clínica Alemana - Universidad del Desarrollo

2008-2009 ESTUDIO EXPERIMENTAL-TEÓRICO DE LA REACCIÓN DE ACETILACIÓN E HIDRÓLISIS EN DERIVADOS DE HIDRAZINA COMO POTENCIALES DROGAS ANTITUBERCULOSAS.
Investigador Responsable
Centro de Gestión # 80.11.046
Clínica Alemana - Universidad del Desarrollo

INTERFACULTADES UDD
2022 CARACTERIZACION FARMACOCINETICA Y FARMACODINAMICA DE CEFTAZIDIMA/AVIBACTAM EN SUERO Y EN LIQUIDO INTERSTICIAL DE PACIENTES CRI?TICOS CON INFECCION POR BACILOS GRAM NEGATIVOS MULTIRRESISTENTES.
Investigador Responsable. Dr. René López MSD.
Co-Investigador. Dra. Paola Campodónico
ICIM-UDD-CAS

CLINICA ALEMANA
2022 CARACTERIZACIO?N FARMACOCINE?TICA Y FARMACODINA?MICA DE CEFTAZIDIMA/AVIBACTAM EN SUERO Y EN LI?QUIDO INTERSTICIAL DE PACIENTES CRI?TICOS CON INFECCIO?N POR BACILOS GRAM NEGATIVOS MULTIRRESISTENTES.
Investigador Responsable. Dr. René López MSD.
Co-Investigador. Dra. Paola Campodónico
ICIM-UDD-CAS

CAPÍTULOS DE LIBROS

PUBLICADOS:
Título Libro: Arene Chemistry: Reaction Mechanisms and Methods for Aromatic Compounds
Capítulo: Computational and Experimental Methods for Predicting Reaction Mechanisms in Nucleophilic Aromatic Substitutions.
Estado Actual: Publicado
Autores: Renato Contreras, Rodrigo Ormazábal-Toledo, Paola R. Campodónico
Editorial: John Wiley & Sons
Editor: Jacques Mortier
País de publicación: ESTADOS UNIDOS DE AMERICA, New York
Año de publicación: 2016

Título Libro: Solvents, Ionic Liquids and Solvent Effects
Capítulo: Studies of Solvent Effects based on a model of SNAr reaction in Conventional and Non-Conventional Solvents.
Estado Actual: publicado
Autores: Paola R. Campodónico
Editorial: IntechOpen
Editor: Daniel Glossman-Mitnik
País de publicación: Inglaterra, Londres.
Año de publicación: 2019

Título Libro: Ionic Liquids: Properties and Applications.
Capítulo: Activation of electrophile/nucleophile pair by a nnucleophilic and electrophilic solvation inn a SNAr reaction.
Estado Actual: Publicado
Editor: Francesca DÁnna and James Harper
Editorial: Frontiers In Chemistry. Ebook.
Año de publicación: 2020

CAPÍTULO LIBRO aceptado 2022:
Libro: "Platinum-Based Chemotherapy: Clinical Uses, Efficacy and Side Effects"
Capítulo: Antineoplastic mechanisms of platinum-analogues, from a biological and chemical point of view.
Autores: Mauricio A. Retamal, Ignacio Cortés-Fuentes, Juan G. Gormaz, and Paola R. Campodónico.


Difusión y Transferencia


PARTICIPACIÓN EN CONGRESOS
• (2021) 31st Conference of the European Society for Biomaterials (ESB2021) together with 43rd Annual Congress of the Iberian Society of Biomechanics and Biomaterials (SIBB). NEW NATURAL SOLVENT IMPROVES BETA-LACTAM ANTIBIOTIC EFFICACY. PORTO, PORTUGAL. Belén Olivares, Marcelo Ezquer, Fabián Martínez, Paola R. Campodónico.

• (2018) 28th ECCMID, the European Congress of Clinical Microbiology and Infectious Diseases. A NATURAL NON-CONVENTIONAL SOLVENT WITH THE POTENTIAL TO STABILIZE BETA-LACTAM ANTIBIOTICS. Madrid, España. Belén Olivares, Lina Rivas, Fabián Martínez, Paola R. Campodónico, José Manuel Munita, Maria Spencer.

• (2018) XXXIII Jornadas Chilenas de Química, Puerto Varas, Chile
REACTIVITY OF BIOTHIOLS TOWARD XENOBIOTICS AND ITS APPLICATION AS ADSORBENT FROM FUNCTIONALIZED POLYMERS
Jazmín Alarcón, Marcela Urzúa, Ricardo Tapia, Renato Contreras, Constanza Garrido and Paola R. Campodónico.

• (2017) 14th Latin American Conference on Physical Organic Chemistry. Concón, Chile.
ADSORPTION STUDIES OF CHROMIUM (VI) REMOVAL FROM WATER BY POLY-(4-VINYLPYRIDINE) TETRAFLUOROBORATE
Javier González-Navarrete, Ximena Briones, Paola R. Campodónico and Marcela Urzúa
EVALUATION OF THE POTENTIAL OF DEEP EUTECTIC SOLVENTS AS A STABILIZING MEDIA FOR LARGE UNILAMELLAR LIPOSOMES (LUVS)
Cristian Calderon, Paola R. Campodonico
FLUORESCENCE OF 1-HYDROXIPYRENO AS A PROBE TO MONITOR THE BASICITY OF ANIONS ON IONIC LIQUIDS FROM THE 1-BUTYL-3-METYL-IMIDAZOLE SERIES
Cristian Calderon, Camila Moreno, Paola R. Campodonico, Eduardo Pino
SOLVENT DEPENDENT KINETICS STUDIES OF 4-CHLOROQUINAZOLINE WITH ANILINE AND HYDRAZINE.
Bruno A. Sanchez, Renato Contreras and Paola R. Campodonico
STUDIES IN SOLVENTS OF VARYING POLARITY
Paola R. Campodónico

• (2016) 2nd Symposyum and Workshop on Design and Application of Ionic Liquids in Chemistry and Physics. Santiago, Chile.
EXPERIMENTAL & THEORETICAL STUDIES ON NUCLEOPHILIC SUBSTITUTION REACTIONS IN SOLVENTS OF VARYING POLARITY.
Paola R. Campodónico
SOLVENT DEPENDENT KINETIC STUDIES OF QUINAZOLINE DERIVATIVES
Bruno A. Sánchez, Cristian Calderón and Paola R. Campodónico
FLUORESCENCE OF 1-HYDROXIPYRENE IN THE PRESENCE OF IONIC LIQUIDS DERIVED FROM THE 1-BUTYL-3-METHYL IMIDAZOLE
Cristian Calderón , Camila Moreno, Eduardo Pino and Paola R. Campodónico
STUDY OF THE ANTIOXIDANT CAPACITY OF NATURALLY OCCURRING SUBSTANCES IN THE PRESENCE OF IONIC LIQUIDS
C. Calderón, D. Moreno, N. Núñez, M. Ordoñez, J.D. Prieto, M. Valdés, M.I. Verdugo, P.R. Campodónico

• (2016) Taller Latinoamericano de Química Verde, Chile.
SOLVENTES NO CONVENCIONALES Y SU USO EN QUÍMICA APLICADA
Paola R. Campodónico

• (2016) 6TH International IUPAC Conference on Green Chemistry- Venezia, Italy.
GUTMANN´S DONOR NUMBERS CORRECTLY ASSESS SOLVENT EFFECTS ON THE KINETICS OF SNAR REACTION IN IONIC LIQUIDS
Jazmín Alarcón- Espósito, Renato Contreras and Paola R. Campodónico

SOLVENT DEPENDENT KINETIC STUDIES OF 4-CHLOROQUINAZOLINE WITH ANILINE AND HYDRAZINE
Bruno A. Sánchez, Renato Contreras and Paola R. Campodónico

PYRENE DERIVATIVES IN IONIC LIQUIDS: HOW DOES THE NATURE OF THE ANION INFLUENCES THE FLUORESCENT BEHAVIOR OF 1-HYDROXYPYRENE? A COMPARISON.
Cristian Calderón, Camila Moreno, Eduardo Pino, Renato Contreras and Paola R. Campodónico

• (2016) 32° Congreso de Química Nacional, 32º Congreso Latinoamericano de Química, en conjunto con las XXXI Jornadas Chilenas de Química. Concepción, Chile.

CHANGES IN THE SNAR REACTION MECHANISM BROUGHT ABOUT BY PREFERENTIAL SOLVATION” Y “EFFECT OF THE MEDIUM IN SNAR BY IONIC LIQUIDS”.
Jazmín Alarcón- Espósito, Renato Contreras and Paola R. Campodónico
EFFECT OF THE MEDIUM IN SNAR BY IONIC LIQUIDS
Jazmín Alarcón- Espósito, Renato Contreras and Paola R. Campodónico

• (2015) 1st Symposyum and Workshop on Design and Application of Ionic Liquids in Chemistry and Physics.Santiago, Chile.

• (2015) 13th Latin American Conference on Physical Organic Chemistry. San Carlos Paz, Argentina
SYNTHESIS AND CHARACTERIZATION OF POLY (IONIC LIQUID) DERIVED FROM N-ALKYL QUATERNIZED POLY(4-VINYLPYRIDINE). EFFECT OF ALKYL CHAIN LENGTH AND MOLECULAR WEIGHT
Ximena Briones , Ricardo Tapia, Renato Contreras, Marcela Urzúa, Ángel Leiva and Paola R. Campodónico

• (2014) 22nd International Conference on Physical Organic Chemistry (ICPOC-22)
Otawa, Canada.
SOLVENT EFFECTS ON 2,4-DINITROPHENYL-4-BENZENESULFONATE AND 2,4-BENZENESULFONATE.

• (2013) XII Congreso Latinoamericano de Fisicoquímica Orgánica (CLAFCO), BRASIL, 2013.
KINETIC STUDY EN SOLVENT EFFECT ON 2,4-DINITROBENZENESULPHONYL CHLORIDE.

• (2013) XIV European Symposium on Organic Reactivity (ESOR), Prague, Czech Republic, 2013.
SOLVENT EFFECT ON 2,4-DINITROBENZENESULPHONYL CHLORIDE.

• (2012) 30 Congreso latinoamericano de Química. Cancún, Mexico.
SOLVENT EFFECT ON 2,4-DINITROBENZENESULFONYL CHLORIDE

• (2011). 11th Latin American Conference on Physical Organic Chemistry. Riviera Maya, Quintana Roo, México
EXPERIMENTAL AND THEORETICAL STUDY ON THE REACTION MECHANISM OF SUBSTITUTED PYRIMIDYNE TOWARDS ALPHA NUCLEOPHILES
KINETICS OF COMPETITIVE REACTIONS OF 2,4-DINITROBENZENESULFONYL CHLORIDE: EXPERIMENTAL AND THEORETICAL STUDIES
LEAVING GROUP EFFECT ON NUCLEOPHILIC AROMATIC SUBSTITUTIONS.
A THEORETICAL AND EXPERIMENTAL STUDY

• (2010) 2do Simposio Iberoamericano de Química Orgánica (BIBEAQO-II) . Santiago de Compostela – España
REACTION MECHANISM OF ARYL ACETATES WITH SECONDARY ALICYCLIC AMINES IN ETHANOL/WATER MIXTURES OF DIFFERENT COMPOSITION

• (2008) 19 th IUPAC Conference on Physical Organic Chemistry. Santiago de Compostela – España
REACTIVITY OF HYDRAZIDE DERIVATIVES BASED ON ACETILATION REACTIONS
PROTON-TRANSPORT CATALYSIS IN INTRAMOLECULAR REARRANGEMENTS. A DENSITY FUNCTIONAL THEORY STUDY

• (2007) 11th European Symposium on Organic Reactivity (ESOR XI). Faro – Portugal
REACTIONS OF ARY CHLOROTHIONOFORMATES WITH QUINUCLIDINES. A KINETIC STUDY

• (2006) From Physics to Biology: The Interface between Experiment and Computation. BIFI 2006. Zaragoza – España

• (2005) 10th European Symposium on Organic Reactivity (ESOR X). Roma – Italia
MECHANISM OF THE REACTIONS OF ARYL 2,4-DINITROPHENYL CARBONATES WITH QUINUCLIDINES. KINETIC AND THEORETICAL STUDY

• (2004) IV Workshop of Computational Chemistry and Molecular Espectroscopy. Punta de Tralca – Chile
RELATIONSHIPS BETWEEN THE ELECTROPHILICITY INDEX AND EXPERIMENTAL RATE COEFFICIENT FOR THE AMINOLYSIS OF THIOLCARBONATES AND DITHIOCARBONATES

• (2003) 9th European Symposium on Organic Reactivity (ESOR IX). Oslo – Noruega
KINETICS AND MECHANISM OF THE REACTIONS OF ARYL CHLOROFORMATES WITH QUINUCLIDINES
ABSOLUTE SCALE OF NUCLEOPHILICITY FROM SOLUTION PHASE IONIZATION POTENTIALS.

• (2002) International Conference on Physical Organic Chemistry 16. (IUPAC). San Diego – Estados Unidos
RELATIONSHIPS BETWEEN NUCLEOPHILICITY/ELECTROPHILICITY INDEXES AND KINETICS PARAMETERS FOR THE REACTIONS OF CARBONYL AND THIOCARBONYL COMPOUNDS WITH NEUTRAL AND CHARGED NUCLEOFILES
KINETICS AND MECHANISM OF THE AMINOLYSES OF 4-NITROPHENYL AND 2,4-DINITROPHENYL METHYL CARBONATES AND PHENYL 2,4-DINITROPHENYL CARBONATE

• (2001) European Symposium of Organic Reactivity 8. Cavtat – Croacia
KINETICS AND MECHANISM IN SOLVÓLISIS OF DIARYL CARBONATES IN AQUEOUS ETHANOL

• (2001) XXIV Jornadas Chilenas de Química. Temuco – Chile
REPARTO DE ADITIVOS EN SOLUCIONES DE MICELAS REVERSAS NO ACUOSAS

• (1999) VI Encuentro Latinoamericano de Fotoquímica y Fotobiología. Teresópolis – Brasil
PROPIEDADES SOLVATOCRÓMICAS DE UN DERIVADO DEL ÁCIDO BARBITÚRICO

• (1999) XXII Jornadas Chilenas de Química. Valdivia – Chile
EFECTO DEL SOLVENTE SOBRE LOS ESPECTROS DE ABSORCIÓN Y EMISIÓN DE UN DERIVADO DEL ÁCIDO BARBITÚRICO

• (1998) XXII Jornadas Chilenas de Química. Puyehue – Chile
EVALUACIÓN DEL CONTENIDO DE FENOLES EN VINOS. UNA METODOLOGÍA ALTERNATIVA AL MÉTODO DEL FOLÍN

• (1996) XXII Congreso Latinoamericano de Química y XXI Jornadas Chilenas de Química. Concepción, Chile
SIMULACIÓN MOLECULAR, ACCIÓN CITOESTÁTICA Y ESTUDIO DE BIOFOROS

• (1996) II Workshop of Computational Chemistry and Molecular Spectroscopy. Valdivia, Chile
MOLECULAR MODELING OF PIRONARIDINE, AN ANTI-MALARIA DRUGS

• (1994) XV Congreso Panamericano de Farmacia y Bioquímica. Buenos Aires, Argentina
ESTUDIO DE ANALOGOS DE 9-ANILINOACRIDINAS COMO INHIBIDORES DE LA ACCIÓN DE LA ADN TOPOISOMERASA


Premios y Distinciones

  •   National award in research

    FONDECYT

    Chile, 2012

    Award for outstanding career in research


 

Article (50)

Betaine-urea deep eutectic solvent improves imipenem antibiotic activity
Gutmann´s Donor and Acceptor Numbers for Ionic Liquids and Deep Eutectic Solvents
How the nature of an alpha-nucleophile determines a Bronsted Type-plot and its reaction pathways. An experimental study
Kinetics and Reaction Mechanism of biothiols involved in SNAr reactions. An Experimental Study.
Effects of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke trial (ADD-SPISE)
Experimental Analyses Emphasize the Stability of the Meisenheimer Complex in a SNAr Reaction Toward Trends in Reaction Pathways
Surfactant-mediated enzymatic superactivity in water/ionic liquid mixtures, evaluated on a model hydrolytic reaction catalyzed by alpha-chymotrypsin
A Natural Deep Eutectic Solvent Formulated to Stabilize beta-Lactam Antibiotics
Activation of Electrophile/Nucleophile Pair by a Nucleophilic and Electrophilic Solvation in a SNAr Reaction
Effect of the nature of the nucleophile and solvent on an SNAr reaction
Self-Sustaining Supramolecular Ionic Liquid Gels for Dye Adsorption
Solvent effect on a model SNAr reaction in ionic liquid/water mixtures at different compositions
Synthesis and characterization of poly (ionic liquid) derivatives of N -alkyl quaternized poly(4-vinylpyridine)
Iso-solvation effects in mixtures of ionic liquids on the kinetics of a model SNAr reaction
Mechanism for the SNAr reaction of atrazine with endogenous thiols: experimental and theoretical study
Gutmann's Donor Numbers Correctly Assess the Effect of the Solvent on the Kinetics of SNAr Reactions in Ionic Liquids
Ionic liquid binary mixtures: how different factors contribute to determine their effect on the reactivity
Changes in the SNAr reaction mechanism brought about by preferential solvation
Mechanistic pathways of aromatic nucleophilic substitution in conventional solvents and ionic liquids
Site activation effects promoted by intramolecular hydrogen bond interactions in SNAr reactions
Hydrogen Bond Contribution to Preferential Solvation in SNAr Reactions
Kinetic and theoretical study on nucleofugality in the phenolysis of 3-nitrophenyl and 4-nitrophenyl 4-cyanophenyl thionocarbonates
Reactivity Indices Profile: A Companion Tool of the Potential Energy Surface for the Analysis of Reaction Mechanisms. Nucleophilic Aromatic Substitution Reactions as Test Case
Specific nucleophile-electrophile interactions in nucleophilic aromatic substitutions
Predicting the reaction mechanism of nucleophilic substitutions at carbonyl and thiocarbonyl centres of esters and thioesters
Are Electrophilicity and Electrofugality Related Concepts? A Density Functional Theory Study
Reactions of Aryl Acetates with Secondary Alicyclic Amines in Ethanol/Water Mixtures: Effect of the Solvent Composition on the Kinetics and Mechanism
Permanent group effect on nucleofugality in aryl benzoates
Reactivity of benzohydrazide derivatives towards acetylation reaction. Experimental and theoretical studies
Electrophilicity of quinones and its relationship with hydride affinity
Experimental and Theoretical Studies on the Nucleofugality Patterns in the Aminolysis and Phenolysis of S-Aryl O-Aryl Thiocarbonates
Proton transport catalysis in intramolecular rearrangements: A density functional theory study
Reactions of aryl chlorothionoformates with quinuclidines. A kinetic study
Structure-reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets
Electrofugality index for benzhydryl derivatives
Nucleofugality index in alpha-elimination reactions
Empirical scale of nucleophilicity for substituted pyridines
Experimental and theoretical study on the substitution reactions of aryl 2,4-dinitrophenyl carbonates with quinuclidines
Group electrophilicity as a model of nucleofugality in nucleophilic substitution reactions
Kinetic and mechanistic study of the reactions of aryl chloroformates with quinuclidines
Relationships between the electrophilicity index and experimental rate coefficients for the aminolysis of thiolearbonates and dithiocarbonates
RELATIONSHIP BETWEEN NUCLEOPHILICITY/ELECTROPHILICITY INDICES AND REACTION MECHANISMS FOR THE NUCLEOPHILIC SUBSTITUTION REACTIONS OF CARBONYL COMPOUNDS
A theoretical study on the relationship between nucleophilicity and ionization potentials in solution phase
Exploratory study of the effect of polar solvents upon the partitioning of solutes in nonaqueous reverse micellar solutions
Kinetics and mechanism of the aminolysis of 4-methylphenyl and 4-chlorophenyl 2,4-dinitrophenyl carbonates in aqueous ethanol
Kinetics and mechanism of the aminolysis of 4-nitrophenyl and 2,4-dinitrophenyl 4-methylphenyl carbonates in aqueous ethanol
Kinetics and mechanism of the aminolysis of methyl 4-nitrophenyl, methyl 2,4-dinitrophenyl, and phenyl 2,4-dinitrophenyl carbonates
Merocyanine-type dyes from barbituric acid derivatives
A comparison between total phenol content of wines and their trap values measured by the bleaching of ABTS radical cations
Modelamiento molecular. 9-anilinoacridina y su intercalacion al adn

BookSection (4)

Platinum analogs from a chemical and biological point of view
ACTIVATION OF ELECTROPHILE/NUCLEOPHILE PAIR BY A NUCLEOPHILIC AND ELECTROPHILIC SOLVATION IN A SNAR REACTION.
Solvents, Ionic Liquids and Solvent Effects
Computational and Experimental methods for predicting reaction mechanisms in nucleophilic aromatic substitutions

Proyecto (20)

CARACTERIZACIÓN FARMACOCINÉTICA Y FARMACODINÁMICA DE CEFTAZIDIMA/AVIBACTAM EN SUERO Y EN LÍQUIDO INTERSTICIAL DE PACIENTES CRÍTICOS CON INFECCIÓN POR BACILOS GRAM NEGATIVOS MULTIRRESISTENTES.
NUEVA FORMULACIÓN PARA LA LIMPIEZA Y DESBRIDAJE EN LA CURACIÓN DE HERIDAS Y ÚLCERAS CUTÁNEAS.
PROGRAMA DE APOYO AL DESARROLLO TECNOLÓGICO DISEÑO, SÍNTESIS Y OPTIMIZACIÓN DE MOLÉCULAS CON ACTIVIDAD ANTINEOPLÁSICA Y SU POSTERIOR EVALUACIÓN BIOLÓGICA. ANÁLISIS E INTERPRETACIÓN DE RESULTADOS QUÍMICOS Y BIOLÓGICOS.
SÍNTESIS DE CATIONES LIPOFILICOS DESLOCALIZADOS DERIVADOS DE 1-AZABENZANTRONA COMO AGENTES QUIMIOTERAPÉUTICOS EN MODELOS AGRESIVOS DE CÁNCER HUMANO: EVALUACIÓN CITOTÓXICA Y ANTIMETASTÁSICA IN VITRO.
SÍNTESIS Y CARACTERIZACIÓN DE MOLÉCULAS PEQUEÑAS ELECTROFÍCAS COMO AGENTES QUIMIOTERAPÉUTICOS EN MODELOS AGRESIVOS DE CÁNCER HUMANO.
EFFECT OF AVOCADO BASED MEDITERRANEAN DIET ON SERUM LIPIDS FOR SECONDARY PREVENTION AFTER ISCHEMIC STROKE
Centro Interdisciplinario de Líquidos Iónicos-CILIS
Experimetal and Theoretical studies on nucleophilic substitution reactions in solvents of varying polarity
Sintesis y caracterizacion de poli8líquidos iónicos). Estudios como medios de reacción
CENTRO INTERDISCIPLINARIO DE LÍQUIDOS IÓNICOS (CILIS)
COMPETICIÓN EN REACCIONES DE SUSTITUCIÓN NUCLEOFÍLICAS MEDIADAS POR EL SOLVENTE. ESTUDIO EXPERIMENTAL-TEÓRICO.
Competición en reacciones de sustitución nucleofílicas mediadas por el solvente. Estudio experimental y teorico
KINETICS AND MECHANISTIC STUDY ON AROMATIC NUCLEOPHILIC SUBSTITUTION REACTIONS IN IONIC LIQUIDS AND MOLECULAR SOLVENT=> EXPERIMENTAL AND THEORETICAL STUDIES.
ESTUDIO CINETICO Y MECANISTICO EN REACCIONES DE SUSTITUCION AROMATICAS EN LIQUIDOS IONICOS. ESTUDIO EXPERIMENTAL Y TEORICO.
AMINOLISYS OF DITHIOCARBONATES. KINETICS, MECHANISMS AND SOLVENT EFFECTS.
ESTUDIO EXPERIMENTAL-TEÓRICO DE LA REACCIÓN DE ACETILACIÓN E HIDRÓLISIS EN DERIVADOS DE HIDRAZINA COMO POTENCIALES DROGAS ANTITUBERCULOSAS.
DESARROLLO DE ESCALAS TEORICAS DE ELECTROFILIA/NUCLEOFILIA EN ACEPTORES DE MICHAEL Y SISTEMAS BIOLOGICOS Y SU APLICACION AL DISENO DE DROGAS ANTITUMORALES.
DESARROLLO DE ESCALAS TEÓRICAS DE ELECTROFILIA/NUCLEOFILIA EN ACEPTORES DE MICHAEL Y SEGMENTOS DE ADN Y SU APLICACIÓN AL DISEÑO DE DROGAS ANTITUMORALES.
IMPLEMENTACIÓN DE DIAGRAMAS ENERGIA-COORDENADA DE REACCION PARA EL ESTUDIO DE MECANISMOS DE REACCION EN QUÍMICA ORGÁNICA. APLICACIÓN AL ESTUDIO DE REACCIONES DE SUSTITUCION NUCLEOFILICA
CINÉTICA Y MECANISMOS DE REACCIÓN DE ARIL CARBONATOS Y ARIL CLOROFORMIATOS CON PIRIDINAS. ESTUDIO EXPERIMENTAL Y TEÓRICO
91
Paola Campodonico

Director of Centro de Química Médica and Associate Professor

CENTRE OF MEDICINAL CHEMISTRY, FACULTY OF MEDICINE, UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

45
Renato Contreras

professor

Quimica

Universidad de Chile

Santiago, Chile

20
José Santos

Professor

Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

7
Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Daniela Millan

Academico investigador

Centro integrativo de biologia y quimica aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

4
cristian calderon

inestigador/profesor

Centro de Química Medica

Universidad del Desarollo

Santiago, Chile

2
Maria Olivares

Docente Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

2
Marjorie Cepeda

Profesor asistente

Ciencias Químicas

Universidad Andrés Bello

Santiago, Chile

2
patricio fuentealba

Profesor Titular

Física

U. DE CHILE, FAC. CIENCIAS, DPTO. FISICA

Santiago, Chile

2
Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

1
Sebastian Gallardo

Profesor colaborador

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paulina Pavez

Associate Professor

Physical Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Ximena Briones

UNIVERSIDAD DEL DESARROLLO

SANTIAGO, Chile

1
Marcela Gazitua

Profesor Investigador

Medicina

Universidad del Desarrollo

Santiago, Chile

1
Marcela Urzúa

Associate Professor

Chemistry

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jose Munita

Profesor Asociado

Internal Medicine

FACULTAD DE MEDICINA CLINICA ALEMANA- UNIVERSIDAD DEL DESARROLLO

Santiago, Chile