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HERNAN ELIAS SPEISKY COSOY

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

Radicales Libres y Estres Oxidativo; Antioxidantes; Polifenoles y sus bioactividades; Antioxidantes en alimentos; Compuestos Bioactivos.

Farmacologia, UNIVERSITY OF TORONTO. Chile, 1986
Químico Farmaceutico, UNIVERSIDAD DE CHILE. Chile, 1978

Profesor Asociado Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Quimica

Santiago, Chile

1988 - 1990
Profesor Titular Full Time

UNIVERSIDAD DE CHILE

Instituto de Nutricion y Tecnología de los Alimentos

Santiago, Chile

1990 - A la fecha
Profesor Titular Part Time

Ciencias Químicas y Farmacéuticas

Santiago, Chile

2007 - 2017

Tesis dirigidas durante los últimos tres años:
Postdoctorado: Elías Atala, Christian Folch, Benjamin Aguilera.
Tesis de Doctorado: Cristian Sandoval, Jocelyn Fuentes, Maria Fernanda Arias.
Tesis de Magister: Maria Jose Wehrhahn, Marianne Holmgren
Tesis de pregrado: Javier Cardenas


Amplification of the antioxidant properties of myricetin, fisetin, and morin following their oxidation Fernanda Arias-Santé, M.; Ojeda, Camila; PASTENE-NAVARRETE, EDGAR RAFAEL Article ISI SCOPUS FOOD CHEMISTRY (2024)
Oxidation of Quercetin and Kaempferol Markedly Amplifies Their Antioxidant, Cytoprotective, and Anti-Inflammatory Properties SPEISKY-COSOY, HERNAN ELIAS Article ISI SCOPUS Antioxidants (2023)
Chickpeas from a Chilean Region Affected by a Climate-Related Catastrophe: Effects of Water Stress on Grain Yield and Flavonoid Composition Bridi, Raquel; Pinaffi-Langley, Ana Clara da C. Article ISI MOLECULES (2022)
Protection against indomethacin-induced loss of intestinal epithelial barrier function by a quercetin oxidation metabolite present in onion peel: In vitro and in vivo studies Brunser, Oscar; Herranz, Jose Article ISI JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)
Revisiting the Oxidation of Flavonoids: Loss, Conservation or Enhancement of Their Antioxidant Properties Speisky, Herna Article ISI ANTIOXIDANTS (2022)
Wheat and Rice beyond Phenolic Acids: Genetics, Identification Database, Antioxidant Properties, and Potential Health Effects Danielski, Renan; Ottani Rhein, Samantha Article ISI PLANTS-BASEL (2022)
Quercetin Oxidation Metabolite Present in Onion Peel Protects Caco-2 Cells against the Oxidative Stress, NF-kappa B Activation, and Loss of Epithelial Barrier Function Induced by NSAIDs Article ISI JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)
Vitamin E as an essential micronutrient for human health: Common, novel, and unexplored dietary sources Pinaffi-Langley, Ana Clara C. Article ISI FREE RADICAL BIOLOGY AND MEDICINE (2021)
Fatty Acid Profile and Bioactive Compound Extraction in Purple Viper's Bugloss Seed Oil Extracted with Green Solvents Galleguillos-Fernandez, Raul; Gonzalez-Barriga, Valeria; Valenzuela, Rodrigo.; Valenzuela, Alfonso Article ISI SCOPUS JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (2020)
Low nanomolar concentrations of a quercetin oxidation product, which naturally occurs in onion peel, protect cells against oxidative damage. Article FOOD CHEMISTRY (2020)
An in vitro study of the antioxidant and antihemolytic properties of Buddleja globosa (Matico) Suwalsky, Mario; Villena, Fernando Article JOURNAL OF MEMBRANE BIOLOGY (2017)
Quercetin and related flavonoids conserve their antioxidant properties despite undergoing chemical or enzymatic oxidation Article FOOD CHEMISTRY (2017)
Quercetin oxidation paradoxically enhances its antioxidant and cytoprotective properties Carrasco-Pozo, Catalina Article JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates Pavani, M.; Jara, JA; Calaf, GM Article TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)
Oxidation of free, peptide and protein tryptophan residues mediated by AAPH-derived free radicals: role of alkoxyl and peroxyl radicals Dorta, E; Escobar, E; Aspée A.; Pino E.; Abasq M.L.; Speisky H.; Silva, E.; Lissi E.; Davies, M. J Article ISI SCOPUS RSC ADVANCES (2016)
Redox-implications associated with the formation of complexes between copper ions and reduced or oxidized glutathione Lopez-Alarcon, C; Bridi R.; Speisky H. Article ISI SCOPUS JOURNAL OF INORGANIC BIOCHEMISTRY (2016)
Total Phenolics and Antioxidant Capacity of Vegetables Grown in The Southwestern Andes Region of South America Montoya, Paulina; Vio, Fernando T. Article JOURNAL OF FOOD AND NUTRITION RESEARCH (2016)
Use of the Oxygen Radical Absorbance Capacity (ORAC) Assay to Predict the Capacity of Mango (Mangifera indica L.) By-Products to Inhibit Meat Protein Oxidation Dorta, E; Rodríguez-Rodríguez E.M.; Jiménez-Quezada A.; Speisky H.; Lissi E. Article SCOPUS Food Analytical Methods (2016)
International Regulations of Propolis Quality: Required Assays do not Necessarily Reflect their Polyphenolic-Related In Vitro Activities Bridi R.; Montenegro,G.; Nunez-Quijada, G; Giordano, A.; Moran-Romero, MF; Jara-Pezoa, I; Speisky H.; Atala E.; Lopez-Alarcon, C Article ISI SCOPUS Journal of Food Science (2015)
The ORAC (oxygen radical absorbance capacity) index does not reflect the capacity of antioxidants to trap peroxyl radicals Dorta, E; Fuentes-Lemus, E; Aspée A.; Atala E.; Speisky H.; Bridi R.; Lissi E.; Lopez-Alarcon, C Article ISI SCOPUS JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2015)
A Polyvinylpolypyrrolidone (PVPP)-Assisted Folin-Ciocalteu Assay to Assess Total Phenol Content of Commercial Beverages Bridi R.; Troncoso, MJ; Folch-Cano, C; Fuentes, J; Speisky H.; Lopez-Alarcon, C Article ISI SCOPUS FOOD ANALYTICAL METHODS (2014)
Evaluation of Latin-American fruits rich in phytochemicals with biological effects Girones-Vilaplana, A; Baenas N.; Villano, D; Speisky H.; Garcia-Viguera, C; Moreno, DA Article ISI SCOPUS JOURNAL OF FUNCTIONAL FOODS (2014)
Identification of the transition state for fast reactions: The trapping of hydroxyl and methyl radicals by DMPO-A DFT approach Aguilera-Venegas, B; Speisky H. Article ISI SCOPUS JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2014)
NMR and molecular fluorescence spectroscopic study of the structure and thermodynamic parameters of EGCG/beta-cyclodextrin inclusion complexes with potential antioxidant activity Folch-Cano, C; Guerrero, J; Speisky H.; Jullian C.; Olea Azar C. Article ISI JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY (2014)
Probiotic Screening and Safety Evaluation of Lactobacillus Strains from Plants, Artisanal Goat Cheese, Human Stools, and Breast Milk Gotteland M.; Cires, MJ; Carvallo C.; Vega, N; Ramirez, MA; Morales P.; Rivas, P; Astudillo F.; Navarrete P.; Dubos C.; et al. Article ISI SCOPUS JOURNAL OF MEDICINAL FOOD (2014)
Role of alkoxyl radicals on the fluorescein-based ORAC (Oxygen Radical Absorbance Capacity) assay Dorta, E; Atala E.; Aspée A.; Speisky H.; Lissi E.; Lopez-Alarcon, C Article ISI FREE RADICAL BIOLOGY AND MEDICINE (2014)
Antioxidant capacity of phenolic compounds in acidic medium: A pyrogallol red-based ORAC (oxygen radical absorbance capacity) assay Atala E.; Aspée A.; Speisky H.; Lissi E.; Lopez-Alarcon, C Article ISI SCOPUS JOURNAL OF FOOD COMPOSITION AND ANALYSIS (2013)
Cu(II)-disulfide complexes display simultaneous superoxide dismutase- and catalase-like activities Andrade-Acuna, D; Lopez-Alarcon, C; Sandoval-Acuna, C; Speisky H. Article ISI SCOPUS Journal of Inorganic Biochemistry (2013)
Mechanism of Pyrogallol Red Oxidation Induced by Free Radicals and Reactive Oxidant Species. A Kinetic and Spectroelectrochemistry Study Atala E.; Velasquez, G.; Vergara C.; Mardones, C.; Reyes, J; Quina, F; Mendes, MA; Speisky H.; Lissi E.; Ureta-Zanartu, MS; et al. Article ISI SCOPUS JOURNAL OF PHYSICAL CHEMISTRY B (2013)
Structural and thermodynamic factors on the adsorption process of phenolic compounds onto polyvinylpolypyrrolidone Folch-Cano, C; Olea Azar C.; Speisky H. Article ISI SCOPUS Colloids and Surfaces A: Physicochemical and Engineering Aspects (2013)
Use of Pyrogallol Red and Pyranine as Probes to Evaluate Antioxidant Capacities towards Hypochlorite Perez-Cruz, F; Cortes C.; Atala E.; Bohle, P; Valenzuela F; Olea Azar C.; Speisky H.; Aspée A.; Lissi E.; Lopez-Alarcon, C; et al. Article ISI SCOPUS MOLECULES (2013)
Application of a microplate-based orac-pyrogallol red assay for the estimation of antioxidant capacity: First action 2012.03 Ortiz, R.; AntilÃ©n M.; Aliaga M.E.; LÃ³pez-AlarcÃ³n C.; Baugh S. Article ISI SCOPUS Journal of AOAC International (2012)
Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells Carrasco-Pozo, C; Speisky H.; Gotteland M. Article ISI SCOPUS Chemico-Biological Interactions (2012)
Electrochemical, ESR and Theoretical Insights into the Free Radical Generation by 1,1 '-Hydrocarbylenebisindazoles and Its Evaluation as Potential Bio-Active Compounds Aguilera-Venegas, B; Olea Azar C.; Aran, VJ; Kemmerling U.; Speisky H.; Mendizabal, F Article ISI SCOPUS International Journal of Electrochemical Science (2012)
First Web-Based Database on Total Phenolics and Oxygen Radical Absorbance Capacity (ORAC) of Fruits Produced and Consumed within the South Andes Region of South America Speisky H.; Lopez-Alarcon, C; Gómez, M.; Fuentes, J; Sandoval-Acuna, C Article ISI SCOPUS Journal of Agricultural and Food Chemistry (2012)
Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action Sandoval-Acuna, C; Lopez-Alarcon, C; Aliaga M.E.; Speisky H. Article ISI SCOPUS Chemico-Biological Interactions (2012)
Redox-changes associated with the glutathione-dependent ability of the Cu(II)-GSSG complex to generate superoxide Aliaga M.E.; Lopez-Alarcon, C; Garcia-Rio, L; Martin-Pastor, M; Speisky H. Article ISI SCOPUS Bioorganic and Medicinal Chemistry (2012)
Analytical Parameters of the Microplate-Based ORAC-Pyrogallol Red Assay Ortiz, R.; Antilen, M; Speisky H.; Lopez-Alarcon, C Article ISI SCOPUS Journal of AOAC International (2011)
Apple Peel Polyphenol Extract Protects against Indomethacin-Induced Damage in Caco-2 Cells by Preventing Mitochondrial Complex I Inhibition Carrasco-Pozo, C; Gotteland M.; Speiskyf, H Article ISI SCOPUS Journal of Agricultural and Food Chemistry (2011)
Apple Peel Polyphenols Protect against Gastrointestinal Mucosa Alterations Induced by Indomethacin in Rats Carrasco-Pozo, C; Speisky H.; Brunser O.; Pastene, E.; Gotteland M. Article ISI SCOPUS Journal of Agricultural and Food Chemistry (2011)
Interaction of 5-aminosalicylic acid with nitrous acid: formation of the diazonium derivative and nitric oxide release Lopez-Alarcon, C; Mella, J; Lissi E.; Hoffmann, P; Speisky H.; Moller M.; Ferrer-Sueta G.; Denicola, A Article ISI SCOPUS CANADIAN JOURNAL OF CHEMISTRY (2011)
Pyrogallol red oxidation induced by superoxide radicals: Application to evaluate redox cycling of nitro compounds Faundez, M; Rojas M.; Bohle, P; Reyes, C.; Letelier, ME; Speisky H.; Lissi E.; Lopez-Alarcon, C Article ISI SCOPUS Analytical Biochemistry (2011)
Role of Superoxide Anions in the Redox Changes Affecting the Physiologically Occurring Cu(I)-Glutathione Complex Speisky H.; Lopez-Alarcon, C; Olea Azar C.; Sandoval-Acuna, C Article ISI SCOPUS Bioinorganic Chemistry and Applications (2011)
Superoxide-dependent reduction of free Fe3+ and release of Fe2+ from ferritin by the physiologically-occurring Cu(I)-glutathione complex Carrasco-Pozo, C; Lopez-Alarcon, C; Olea Azar C.; Speisky H. Article ISI SCOPUS Bioorganic and Medicinal Chemistry (2011)
Time-dependence of Ferric Reducing Antioxidant Power (FRAP) index in Chilean apples and berries Henriquez, C; Lopez-Alarcon, C; Lutz M.G.M.; Speisky H. Article ISI SCOPUS ARCHIVOS LATINOAMERICANOS DE NUTRICION (2011)
Antioxidant activity of inclusion complexes of tea catechins with ?-cyclodextrins by ORAC assays Folch-Cano, C; Olea Azar C.; Jullian C.; Speisky H. Article FOOD RESEARCH INTERNATIONAL (2010)
Antioxidant activity of inclusion complexes of tea catechins with beta-cyclodextrins by ORAC assays Folch-Cano, C; Jullian C.; Speisky H.; Olea Azar C. Article ISI SCOPUS Food Research International (2010)
DETERMINATION OF ANTIOXIDANT CAPACITY, TOTAL PHENOLIC CONTENT AND MINERAL COMPOSITION OF DIFFERENT FRUIT TISSUE OF FIVE APPLE CULTIVARS GROWN IN CHILE Henriquez, C; Almonacid, S; Chiffelle I.; Valenzuela, T; Araya M.; Cabezas L.; Simpson, R; Speisky H. Article ISI SCIELO Chilean journal of agricultural research (2010)
Determination of antioxidant capacity, total phenolic content and mineral composition of different fruit tissue of five apple cultivars grown in Chile Determinación de la capacidad antioxidante, contenido de fenoles totales y composición mineral de diferentes tejidos de frutos de cinco variedades de manzana cultivadas en Chile Henriquez, C; Almonacid, S; Simpson, R; Chiffelle I.; Valenzuela, T; Araya M.; Cabezas L.; Speisky H. Article SCOPUS Chilean Journal of Agricultural Research (2010)
Development of an Ingredient Containing Apple Peel, as a Source of Polyphenols and Dietary Fiber Henriquez, C; Speisky H.; Chiffelle I.; Valenzuela, T; Araya M.; Simpson, R; Almonacid, S Article ISI SCOPUS Journal of Food Science (2010)
In Vitro and in Vivo Effects of Apple Peel Polyphenols against Helicobacter pylori Pastene, E.; Speisky, F; Garcia, A.; Moreno, J; Troncoso M.; Figueroa G. Article ISI SCOPUS Journal of Agricultural and Food Chemistry (2010)
Protection by apple peel polyphenols against indometacin-induced oxidative stress, mitochondrial damage and cytotoxicity in Caco-2 cells Carrasco-Pozo, C; Gotteland M.; Speisky H. Article ISI JOURNAL OF PHARMACY AND PHARMACOLOGY (2010)
Redox-active complexes formed during the interaction between glutathione and mercury and/or copper ions Lopez-Alarcon, C; Barriga, G; Olea Azar C.; Speisky H. Article ISI SCOPUS Journal of Inorganic Biochemistry (2010)
The Cu(I)-glutathione complex: factors affecting its formation and capacity to generate reactive oxygen species Carrasco-Pozo, C; Lopez-Alarcon, C; Speisky H. Article ISI SCOPUS Transition Metal Chemistry (2010)
A SYSTEM FOR DETECTION OF VOLATILE ANTIOXIDANT COMMONLY EMITTED FROM SPICES AND MEDICINAL HERBS Pastene, E.; Gómez, M.; Speisky H.; Nunez-Vergara, L Article ISI QUIMICA NOVA (2009)
A system for detection of volatile antioxidant commonly emitted from spices and medicinal herbs Un sistema para la deteccion de antioxidantes volatiles comunmente emitidos desde especias y hierbas medicinales Pastene, E.; Gómez, M.; Speisky H.; Nunez-Vergara, L Article SCOPUS QUIMICA NOVA (2009)
Ascorbic acid contribution to ORAC values in berry extracts: An evaluation by the ORAC-pyrogallol red methodology Atala E.; Vásquez, L.; Speisky H.; Lissi E.; Lopez-Alarcon, C Article ISI SCOPUS FOOD CHEMISTRY (2009)
Association between Polymerization Degree of Apple Peel Polyphenols and Inhibition of Helicobacter pylori Urease Pastene, E.; Troncoso M.; Figueroa G.; Alarcon J.; Speisky H. Article ISI SCOPUS JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)
Determination of reactions between free radicals and selected Chilean wines and transition metals by ESR and UV-vis technique Espinoza M.; Olea Azar C.; Speisky H.; Rodriguez J. Article ISI SCOPUS SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2009)
Generation of superoxide radicals by copper-glutathione complexes: Redox-consequences associated with their interaction with reduced glutathione Speisky H.; Gómez, M.; Burgos-Bravo, F; Lopez-Alarcon, C; Jullian C.; Olea Azar C. Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2009)
In Vitro Inhibitory Effect of Apple Peel Extract on the Growth of Helicobacter pylori and Respiratory Burst Induced on Human Neutrophils Pastene, E.; Speisky H.; Troncoso M.; Alarcon J.; Figueroa G. Article ISI SCOPUS JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)
Characterization of pi(n)over-tildeon seed (Araucaria araucana (Mol) K. Koch) and the isolated starch from the seed Henriquez, C; Escobar B.; Figuerola, F.; Chiffelle I.; Speisky H.; Estevez, AM Article ISI SCOPUS FOOD CHEMISTRY (2008)
Characterization of piñon seed (Araucaria araucana (Mol) K. Koch) and the isolated starch from the seed Henriquez, C; Escobar B.; Chiffelle I.; Figuerola, F.; Speisky H. Article FOOD CHEMISTRY (2008)
Cu(I)-glutathione complex: A potential source of superoxide radicals generation Speisky H.; Gómez, M.; Carrasco-Pozo, C; Pastene, E.; Lopez-Alarcon, C; Olea Azar C. Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Double edge redox-implications for the interaction between endogenous thiols and copper ions: In vitro studies Carrasco-Pozo, C; Olea Azar C.; Speisky H. Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Effect of Dried Extract of Boldo (Peumus Boldus Mol.) on Growth and Oxidative Tissue Status of Broiler Chickens Fellenberg, MA; Delporte C.; Backhouse, N; Pena, I; Speisky H. Article ISI SCOPUS BRAZILIAN JOURNAL OF POULTRY SCIENCE (2008)
Modulation of Helicobacter pylori colonization with cranberry juice and Lactobacillus johnsonii La1 in children Gotteland M.; Andrews, M; Toledo, M.; Munoz L.; Cáceres P.; Anziani, A; Wittig, E; Speisky H.; Salazar G. Article ISI SCOPUS NUTRITION (2008)
Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation Lopez-Alarcon, C; Speisky H.; Lissi E. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2007)
Content of flavonoids and phenolic compounds in Chilean honeys. ORAC index Contenido de flavonoides y compuestos fenólicos de mieles Chilenas e índice antioxidante Muñoz, O.; Copaja, S.; Speisky H.; Montenegro,G. Article QUIMICA NOVA (2007)
Content of flavonoids and phenolic compounds in Chilean honeys. Orac index. Muñoz, O.; Copaja, S.; Speisky H.; Pena, RC; Montenegro,G. Article ISI QUIMICA NOVA (2007)
Antioxidant screening of medicinal herbal teas Speisky H.; Rocco C.; Carrasco, C.; Lissi, EA; Lopez-Alarcon, C Article ISI SCOPUS PHYTOTHERAPY RESEARCH (2006)
Antioxidants: their effects on broiler oxidative stress and its meat oxidative stability Fellenberg, MA; Speisky H. Article ISI WORLDS POULTRY SCIENCE JOURNAL (2006)
In vitro interaction between homocysteine and copper ions: Potential redox implications Carrasco-Pozo, C; Alvarez-Lueje, A; Olea Azar C.; Lopez-Alarcon, C; Speisky H. Article ISI EXPERIMENTAL BIOLOGY AND MEDICINE (2006)
Microsomal UDP-glucuronyltransferase in rat liver: Oxidative activation Pimentel A.; Pino, P; FaÃºndez M.; Aracena P.; Speisky H. Article ISI SCOPUS BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2005)
Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity Letelier, ME; Lepe, AM; Faundez, M; Salazar J.; Marín R.; Aracena P.; Speisky H. Article ISI SCOPUS CHEMICO-BIOLOGICAL INTERACTIONS (2005)
Reaction of 5-aminosalicylic acid with peroxyl radicals: Protection and recovery by ascorbic acid and amino acids Lopez-Alarcon, C; Rocco C.; Lissi E.; Carrasco, C.; Squella, JA; Nunez-Vergara, L; Speisky H. Article ISI SCOPUS PHARMACEUTICAL RESEARCH (2005)
A novel alkaloid antioxidant, Boldine and synthetic antioxidant, reduced form of RU486, inhibit the oxidation of LDL in-vitro and atherosclerosis in vivo in LDLR-/(-) mice Santanam, N; Penumetcha, M; Speisky H.; Parthasarathya, S Article ISI SCOPUS ATHEROSCLEROSIS (2004)
Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells Gallardo V.; Muñoz P; Tapia, V; Esparza A.; Salazar J.; Speisky H. Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2004)
Reactivity of 1,4-dihydropyridines toward SIN-1-derived peroxynitrite Lopez-Alarcon, C; Speisky H.; Squella, JA; Olea Azar C.; Camargo C.; Nunez-Vergara, LJ Article ISI PHARMACEUTICAL RESEARCH (2004)
Copper exposure and potential biomarkers of copper metabolism Araya M.; Olivares M.; Pizarro, F; GONZALEZ, M; Speisky H.; Uauy R. Article ISI BIOMETALS (2003)
Copper-binding proteins in human erythrocytes: Searching for potential biomarkers of copper over-exposure Speisky H.; Navarro P.; Cherian, MG; Jimenez, I. Article ISI BIOMETALS (2003)
Effects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice Loghin, F; Chagraoui, A; Asencio M.; Comoy, E; Speisky H.; Protais, P Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2003)
Gastrointestinal symptoms and blood indicators of copper load in apparently healthy adults undergoing controlled copper exposure Araya M.; Olivares M.; Pizarro, F; GONZALEZ, M; Speisky H.; Uauy R. Article ISI SCOPUS AMERICAN JOURNAL OF CLINICAL NUTRITION (2003)
Chronic exposure of HepG2 cells to excess copper results in depletion of glutathione and induction of metallothionein Jimenez, I.; Aracena P.; Letelier, ME; Navarro P.; Speisky H. Article ISI SCOPUS TOXICOLOGY IN VITRO (2002)
Biological disposition of boldine: in vitro and in vivo studies Jimenez, I.; Speisky H. Article ISI SCOPUS PHYTOTHERAPY RESEARCH (2000)
Effects of copper ions on the free radical-scavenging properties of reduced gluthathione: implications of a complex formation Jimenez, I.; Speisky H. Article ISI SCOPUS JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2000)
Free-radical-induced inactivation of lysozyme and carbonyl residue generation in protein are not necessarily associated Jimenez, I.; Lissi, EA; Speisky H. Article ISI SCOPUS ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)
Protective effects of boldine against free radical-induced erythrocyte lysis Jimenez, I.; Garrido, A; Bannach, R; Gotteland M.; Speisky H. Article ISI SCOPUS PHYTOTHERAPY RESEARCH (2000)
Concentration and stabilization of n-3 polyunsaturated fatty acids from sardine oil Ganga A.; Romo, C.; Nieto S.; Sanhuez J.; Speisky H.; Valenzuela A. Article JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (1998)
Copper in infant nutrition: Safety of World Health Organization provisional guideline value for copper content of drinking water Olivares M.; Pizarro, F; Speisky H.; Uauy R.; Lonnerdal, B Article JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (1998)
Fatty acid composition, extraction, fractionation, and stabilization of bullfrog (Rana catesbeiana) oil Mendez, E; Sanhueza, J; Speisky H.; Valenzuela A.; Nieto S. Article JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (1998)
Comparison of rancimat evaluation modes to assess oxidative stability of fish oils Mendez, E; Sanhueza, J; Speisky H.; Valenzuela A. Article JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (1997)
DMPS-arsenic challenge test. I: Increased urinary excretion of monomethylarsonic acid in humans given dimercaptopropane sulfonate Aposhian H.V.; Aposhian M.M.; Arroyo, A.; Del Razo L.M.; Hurlbut K.M.; Dart R.C.; Gonzalez-Ramirez D.; Kreppel H.; Speisky H.; Smith, A; et al. Article JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (1997)
Loss of the metal binding properties of metallothionein induced by hydrogen peroxide and free radicals Jimenez, I.; Uauy R.; Speisky H.; Gotteland M.; Zarzuelo A. Article TOXICOLOGY (1997)
Protective effect of boldine in experimental colitis Cotteland M.; Brunser O.; Guzman, L; Romero, S.; Cassels, B.K.; Jimenez, I.; Speisky H. Article PLANTA MEDICA (1997)
Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes Bannach, R; Valenzuela A.; Speisky H.; Cassels, B.K.; Nuñez-Vergara, L. J. Article Cell Biology and Toxicology (1996)
Validation of the rancimat test for the assessment of the relative stability of fish oils Mendez, E; Sanhueza, J; Speisky H.; Valenzuela A. Article JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (1996)


CYTOTOXIC EFFECT OF GENTISIC ACID AND PROTOCATECHUIC ACID TRIPHENYLPHOSPHONIUM DERIVATIVES IN HUMAN BREAST CANCER CELLS: POSSIBLE MECHANISM AND BIOENERGETIC IMPLICATIONS Sandoval-Acuna, C; Fuentes-Retamal, S; Guzman-Rivera, D; Speisky H.; Castro-Castillo, V; Madrid-Rojas, M; Ferreira J. Abstract ISI Anticancer research. (2014)
1,3-Disubstituted-5-nitroindazole derivatives are inhibitors and subversive substrates of trypanothione reductase from Trypanosoma cruzi Aguilera-Venegas, B; Olea Azar C.; Speisky H.; Aran, AVJ; Krauth-Siegel, RL Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2013)
Assessment of the redox cycling properties of nitrocompounds using a superoxide-dependent pyrogallol red bleaching assay Speisky H.; Lissi E.; Rojas M.; Faundez, M Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2012)
Protective effect of various polyphenols against mitochondrial dysfunction induced by indomethacin in caco-2 cells Carrasco-Pozo, C; Speisky H.; Gotteland M. Abstract ISI ANNALS OF NUTRITION AND METABOLISM (2011)
SELECTION OF STRAINS OF LACTOBACILLI AND BIFIDOBACTERIA WITH PROBIOTIC POTENTIAL Figueroa G.; Gotteland M.; Troncoso M.; Vega, N; Astudillo F.; Rivas, P; Gómez, M.; Speisky H. Abstract ISI PEDIATRIC RESEARCH (2010)
Antioxidant versus pro-oxidant effects of thio- amino acids in their interaction with copper ions: In vitro studies Speisky H.; Carrasco, C.; Alvarez A.; Olea Azar C. Abstract ISI PLACENTA (2006)
Cross-talk between iron and GSH homeostasis in neuronal cells Gallardo V.; Muñoz P; Tapia, V; Aguirre, R.; Esparza A.; Speisky H. Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2004)


Evaluation of the antioxidant capacity of food samples: a chemical examination of the oxygen radical absorbance capacity assay BookSection (2017)
Antioxidantes en verduras y frutas en: Los colores de la salud. 3 Verduras y 2 Frutas al día BookSection (2016)
Generation of Superoxide by the Interaction Between Mercury Ions and Endogenous Thiols Aliaga, Margarita; Vásquez-Arce, Alexis; López-Alarcón, Camilo; Olea Azar, Claudio; Barriga, Germán; Speisky, Hernán; Kim, Ki-Hyun; Brown, Richard J. C. BookSection (2013)


Antioxidant Content and Activity in Different Structures of Five Apple Cultivars Grown in Chile Henriquez, C; Almonacid, S; Escobar B.; Chiffelle I.; Gómez, M.; Speisky H. ConferencePaper ISI SCOPUS IX INTERNATIONAL CONFERENCE ON GRAPE GENETICS AND BREEDING (2009)
Antioxidants in chilean berries Speisky H.; Gómez, M.; Gotteland M.; Brunser O.; Peña A; Fredes, C.; Hurtado, M. ConferencePaper IX INTERNATIONAL CONFERENCE ON GRAPE GENETICS AND BREEDING (2008)
Slow and fast-reacting antioxidants from berries: Their evaluation through the FRAP (ferric reducing antioxidant power) assay Henriquez, C; Carrasco-Pozo, C; Gómez, M.; Brunser O.; Speisky H. ConferencePaper IX INTERNATIONAL CONFERENCE ON GRAPE GENETICS AND BREEDING (2008)
Slow and fast-reacting. antioxidants from berries: Their evaluation through the FRAP (Ferric reducing antioxidant power) assay Henriquez, C; Carrasco-Pozo, C; Gómez, M.; Brunser O.; Speisky H. ConferencePaper ISI IX INTERNATIONAL CONFERENCE ON GRAPE GENETICS AND BREEDING (2008)


Effects of copper ions on the free radical-scavenging properties of homocysteine: Implications of a complex formation Jimenez, I.; Navarro P.; Olea Azar C.; Speisky H. EditorialMaterial BIOMETALS (2003)


Effect of Epicatechin on Skeletal Muscle Review ISI CURRENT MEDICINAL CHEMISTRY (2022)
Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions Sandoval-Acuna, C; Ferreira J.; Speisky H. Review ISI SCOPUS ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)
Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi Aguilera-Venegas, B; Olea Azar C.; Aran, VJ; Speisky H. Review ISI SCOPUS FUTURE MEDICINAL CHEMISTRY (2013)
Boldine and its antioxidant or health-promoting properties O'Brien, P.; Carrasco-Pozo, C; Speisky H. Review ISI CHEMICO-BIOLOGICAL INTERACTIONS (2006)

Edgar Pastene

Profesor

Ciencias Básias

Universidad del Bío-Bío

Chillán, Chile

Fernando Mendizabal

Full Professor

Chemistry

UNIVERSIDAD DE CHILE - FACULTAD DE CIENCIAS

Santiago, Chile

Juan Squella

Académico

Química Orgánica y Físico Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

Claudia Mardones

Académica

Departamento Análisis Instrumental

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

CAROLINA JULLIAN

Profesor Asociado

Quimica Organica y Fisicoquimica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Gloria Montenegro

Profesor Titular

Departamento Ciencias Vegetales

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ricardo Simpson

Professor

Chemical and Environmental Engineering Department

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

VALPARAISO, Chile

Sergio Almonacid

Profesor Titular

Departament of Chemical and Environmental Engineering

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

Camilo López

prof. Asociado

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

MONICA ANTILEN

Profesora Titular

quimica Inorganica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ricardo Uauy

Professor

Pontificia Universidad Catolica de Chile

Santiago, Chile

Maria Soledad Ureta

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

Carla Delporte

Profesor titular

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD CIENCIAS QUÍMICAS Y FARMACÉUTICAS

SANTIAGO, Chile

Juan Guerrero

ACADEMICO

QUÍMICA DE LOS MATERIALES

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Ady Giordano

Profesor Asistente

Química

Pontificia Universidad Católica de Chile

Santiago, Chile

Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

Andrés Schwember

Profesor Asociado

Ciencias Vegetales

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Jorge Rodriguez

Professor

Department of Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

La Florida, Chile

Carola Vergara

Profesor Asociado

Departamento de Análisis Instrumental

Universidad de Concepción

Concepcion, Chile

ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

117

HERNAN SPEISKY

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

Eduardo Pino

Acádemico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Apolinaria García

Investigador

Microbiology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Mónica Andrews

INTA

Santiago, Chile

Loreto Muñoz

Full Professor

Faculty of Medicine and Health Sciences

Universidad Central de Chile

Santiago, Chile, Chile

Fernando Pizarro

Profesor Titular

INTA-UNIVERSIDAD DE CHILE

Santiago, Chile

Raquel Bridi

Profesor Asociado

Departamento de Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

EVA DORTA

Investigador Asociado

Química-Física

Pontificia Universidad Católica de Chile

Santiago, Chile

Claudia Carvallo

Investigadora Principal, Centro de investigación e Innovación en Gerontología Aplicada (CIGAP)

Biología

Universidad Santo Tomás

Santiago, Chile

Germán Barriga

Asociado

Quimica

Universidad Metropolitana de Ciencias de la Educación

Ñuñoa, Chile

Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

Elias Atala

Head of Science & Technology

R & D

Q-VANT Bioscience

Santiago, Chile

Miguel Ángel Rincón

Académico profesor asociado

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS

Santiago, Chile

Pamela Morales

Docente

Nutrición y Dietética

Universidad Bernardo O`Higgins

Santiago, Chile

Paola Navarrete

Associate Professor

INTA

Universidad de Chile

Santiago, Chile

Julio Salazar

Médico

Neurología

Unidad de Neurología, Hospital San José

Santiago, Chile

María Mizgier

Postdoctorate

Universidad de Los Andes

Santiago, Chile

JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

Maria Angelica Fellenberg

profesor asociado

Pontificia Universidad Católica de Chile

Santiago, Chile

Loreto Muñoz

Academic - researcher

Universidad Central de Chile

Santiago, Chile

Rodrigo Valenzuela

Profesor Asociado

Nutrición

Universidad de Chile

Santiago, Chile

PAOLA CACERES

ACADEMICO

NUTRICION

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Guillermo Figueroa

Profesor Asociado

Laboratorio: Microbiología de Alimentos y Probióticos

INTA, Universidad de Chile

Santiago, Chile

Jocelyn Fuentes

JEFA DEL LABORATORIO DE ANTIOXIDANTES

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Eduardo Fuentes

Profesor Asistente

Química Física

Pontificia Universidad Católica de Chile

Santiago, Chile

Adriano Costa de Camargo

Profesor Asistente

Instituto de Nutrición y Tecnología de los Alimentos

Universidad de Chile

Santiago, Chile

Daniela Andrade

academico

Universidad Austral de Chile

puerto montt , Chile

Fernanda Perez

Investigadora senior principal

Síntesis orgánica

Ientropia SPA

Santiago, Chile

Francisco Valenzuela

Farmacovigilancia de vacunas

ISP

Santiago, Chile

HERNAN ELIAS SPEISKY COSOY

Líneas de Investigación

Educación

Farmacologia, UNIVERSITY OF TORONTO. Chile, 1986

Químico Farmaceutico, UNIVERSIDAD DE CHILE. Chile, 1978

Experiencia Académica

Profesor Asociado Full Time

Profesor Titular Full Time

Profesor Titular Part Time

Formación de Capital Humano

Article (97)

Abstract (7)

BookSection (3)

ConferencePaper (4)

EditorialMaterial (1)

Review (4)