Man

Hernan Elias Speisky Cosoy

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

Líneas de Investigación


Radicales Libres y Estres Oxidativo; Antioxidantes; Polifenoles y sus bioactividades; Antioxidantes en alimentos; Compuestos Bioactivos.

Educación

  •  Farmacologia, UNIVERSITY OF TORONTO. Chile, 1986
  •  Químico Farmaceutico, UNIVERSIDAD DE CHILE. Chile, 1978

Experiencia Académica

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Quimica

    Santiago, Chile

    1988 - 1990

  •   Profesor Titular Full Time

    UNIVERSIDAD DE CHILE

    Instituto de Nutricion y Tecnología de los Alimentos

    Santiago, Chile

    1990 - A la fecha

  •   Profesor Titular Part Time

    Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2007 - 2017

Formación de Capital Humano


Tesis dirigidas durante los últimos tres años:
Postdoctorado: Elías Atala, Christian Folch, Benjamin Aguilera.
Tesis de Doctorado: Cristian Sandoval, Jocelyn Fuentes, Maria Fernanda Arias.
Tesis de Magister: Maria Jose Wehrhahn, Marianne Holmgren
Tesis de pregrado: Javier Cardenas



 

Article (89)

Fatty Acid Profile and Bioactive Compound Extraction in Purple Viper's Bugloss Seed Oil Extracted with Green Solvents
Low nanomolar concentrations of a quercetin oxidation product, which naturally occurs in onion peel, protect cells against oxidative damage.
An in vitro study of the antioxidant and antihemolytic properties of Buddleja globosa (Matico)
Quercetin and related flavonoids conserve their antioxidant properties despite undergoing chemical or enzymatic oxidation
Quercetin oxidation paradoxically enhances its antioxidant and cytoprotective properties
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates
Oxidation of free, peptide and protein tryptophan residues mediated by AAPH-derived free radicals: Role of alkoxyl and peroxyl radicals
Redox-implications associated with the formation of complexes between copper ions and reduced or oxidized glutathione
Total Phenolics and Antioxidant Capacity of Vegetables Grown in The Southwestern Andes Region of South America
Use of the Oxygen Radical Absorbance Capacity (ORAC) Assay to Predict the Capacity of Mango (Mangifera indica L.) By-Products to Inhibit Meat Protein Oxidation
International Regulations of Propolis Quality: Required Assays do not Necessarily Reflect their Polyphenolic-Related In Vitro Activities
The ORAC (oxygen radical absorbance capacity) index does not reflect the capacity of antioxidants to trap peroxyl radicals
A Polyvinylpolypyrrolidone (PVPP)-Assisted Folin-Ciocalteu Assay to Assess Total Phenol Content of Commercial Beverages
Evaluation of Latin-American fruits rich in phytochemicals with biological effects
Identification of the transition state for fast reactions: The trapping of hydroxyl and methyl radicals by DMPO-A DFT approach
NMR and molecular fluorescence spectroscopic study of the structure and thermodynamic parameters of EGCG/beta-cyclodextrin inclusion complexes with potential antioxidant activity
Probiotic Screening and Safety Evaluation of Lactobacillus Strains from Plants, Artisanal Goat Cheese, Human Stools, and Breast Milk
Role of alkoxyl radicals on the fluorescein-based ORAC (Oxygen Radical Absorbance Capacity) assay
Antioxidant capacity of phenolic compounds in acidic medium: A pyrogallol red-based ORAC (oxygen radical absorbance capacity) assay
Cu(II)-disulfide complexes display simultaneous superoxide dismutase- and catalase-like activities
Mechanism of Pyrogallol Red Oxidation Induced by Free Radicals and Reactive Oxidant Species. A Kinetic and Spectroelectrochemistry Study
Structural and thermodynamic factors on the adsorption process of phenolic compounds onto polyvinylpolypyrrolidone
Use of Pyrogallol Red and Pyranine as Probes to Evaluate Antioxidant Capacities towards Hypochlorite
Application of a microplate-based orac-pyrogallol red assay for the estimation of antioxidant capacity: First action 2012.03
Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells
Electrochemical, ESR and Theoretical Insights into the Free Radical Generation by 1,1 '-Hydrocarbylenebisindazoles and Its Evaluation as Potential Bio-Active Compounds
First Web-Based Database on Total Phenolics and Oxygen Radical Absorbance Capacity (ORAC) of Fruits Produced and Consumed within the South Andes Region of South America
Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action
Redox-changes associated with the glutathione-dependent ability of the Cu(II)-GSSG complex to generate superoxide
Analytical Parameters of the Microplate-Based ORAC-Pyrogallol Red Assay
Apple Peel Polyphenol Extract Protects against Indomethacin-Induced Damage in Caco-2 Cells by Preventing Mitochondrial Complex I Inhibition
Apple Peel Polyphenols Protect against Gastrointestinal Mucosa Alterations Induced by Indomethacin in Rats
Interaction of 5-aminosalicylic acid with nitrous acid: formation of the diazonium derivative and nitric oxide release
Pyrogallol red oxidation induced by superoxide radicals: Application to evaluate redox cycling of nitro compounds
Role of Superoxide Anions in the Redox Changes Affecting the Physiologically Occurring Cu(I)-Glutathione Complex
Superoxide-dependent reduction of free Fe3+ and release of Fe2+ from ferritin by the physiologically-occurring Cu(I)-glutathione complex
Time-dependence of Ferric Reducing Antioxidant Power (FRAP) index in Chilean apples and berries
Antioxidant activity of inclusion complexes of tea catechins with ?-cyclodextrins by ORAC assays
Antioxidant activity of inclusion complexes of tea catechins with beta-cyclodextrins by ORAC assays
DETERMINATION OF ANTIOXIDANT CAPACITY, TOTAL PHENOLIC CONTENT AND MINERAL COMPOSITION OF DIFFERENT FRUIT TISSUE OF FIVE APPLE CULTIVARS GROWN IN CHILE
Determination of antioxidant capacity, total phenolic content and mineral composition of different fruit tissue of five apple cultivars grown in Chile Determinación de la capacidad antioxidante, contenido de fenoles totales y composición mineral de diferentes tejidos de frutos de cinco variedades de manzana cultivadas en Chile
Development of an Ingredient Containing Apple Peel, as a Source of Polyphenols and Dietary Fiber
In Vitro and in Vivo Effects of Apple Peel Polyphenols against Helicobacter pylori
Protection by apple peel polyphenols against indometacin-induced oxidative stress, mitochondrial damage and cytotoxicity in Caco-2 cells
Redox-active complexes formed during the interaction between glutathione and mercury and/or copper ions
The Cu(I)-glutathione complex: factors affecting its formation and capacity to generate reactive oxygen species
A SYSTEM FOR DETECTION OF VOLATILE ANTIOXIDANT COMMONLY EMITTED FROM SPICES AND MEDICINAL HERBS
A system for detection of volatile antioxidant commonly emitted from spices and medicinal herbs Un sistema para la deteccion de antioxidantes volatiles comunmente emitidos desde especias y hierbas medicinales
Ascorbic acid contribution to ORAC values in berry extracts: An evaluation by the ORAC-pyrogallol red methodology
Association between Polymerization Degree of Apple Peel Polyphenols and Inhibition of Helicobacter pylori Urease
Determination of reactions between free radicals and selected Chilean wines and transition metals by ESR and UV-vis technique
Generation of superoxide radicals by copper-glutathione complexes: Redox-consequences associated with their interaction with reduced glutathione
In Vitro Inhibitory Effect of Apple Peel Extract on the Growth of Helicobacter pylori and Respiratory Burst Induced on Human Neutrophils
Characterization of pi(n)over-tildeon seed (Araucaria araucana (Mol) K. Koch) and the isolated starch from the seed
Characterization of piñon seed (Araucaria araucana (Mol) K. Koch) and the isolated starch from the seed
Cu(I)-glutathione complex: A potential source of superoxide radicals generation
Double edge redox-implications for the interaction between endogenous thiols and copper ions: In vitro studies
Effect of Dried Extract of Boldo (Peumus Boldus Mol.) on Growth and Oxidative Tissue Status of Broiler Chickens
Modulation of Helicobacter pylori colonization with cranberry juice and Lactobacillus johnsonii La1 in children
Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
Content of flavonoids and phenolic compounds in Chilean honeys. ORAC index Contenido de flavonoides y compuestos fenólicos de mieles Chilenas e índice antioxidante
Content of flavonoids and phenolic compounds in Chilean honeys. Orac index.
Antioxidant screening of medicinal herbal teas
Antioxidants: their effects on broiler oxidative stress and its meat oxidative stability
In vitro interaction between homocysteine and copper ions: Potential redox implications
Microsomal UDP-glucuronyltransferase in rat liver: Oxidative activation
Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity
Reaction of 5-aminosalicylic acid with peroxyl radicals: Protection and recovery by ascorbic acid and amino acids
A novel alkaloid antioxidant, Boldine and synthetic antioxidant, reduced form of RU486, inhibit the oxidation of LDL in-vitro and atherosclerosis in vivo in LDLR-/(-) mice
Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells
Reactivity of 1,4-dihydropyridines toward SIN-1-derived peroxynitrite
Copper exposure and potential biomarkers of copper metabolism
Copper-binding proteins in human erythrocytes: Searching for potential biomarkers of copper over-exposure
Effects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice
Gastrointestinal symptoms and blood indicators of copper load in apparently healthy adults undergoing controlled copper exposure
Chronic exposure of HepG2 cells to excess copper results in depletion of glutathione and induction of metallothionein
Biological disposition of boldine: in vitro and in vivo studies
Effects of copper ions on the free radical-scavenging properties of reduced gluthathione: implications of a complex formation
Free-radical-induced inactivation of lysozyme and carbonyl residue generation in protein are not necessarily associated
Protective effects of boldine against free radical-induced erythrocyte lysis
Concentration and stabilization of n-3 polyunsaturated fatty acids from sardine oil
Copper in infant nutrition: Safety of World Health Organization provisional guideline value for copper content of drinking water
Fatty acid composition, extraction, fractionation, and stabilization of bullfrog (Rana catesbeiana) oil
Comparison of rancimat evaluation modes to assess oxidative stability of fish oils
DMPS-arsenic challenge test. I: Increased urinary excretion of monomethylarsonic acid in humans given dimercaptopropane sulfonate
Loss of the metal binding properties of metallothionein induced by hydrogen peroxide and free radicals
Protective effect of boldine in experimental colitis
Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes
Validation of the rancimat test for the assessment of the relative stability of fish oils

Abstract (7)

CYTOTOXIC EFFECT OF GENTISIC ACID AND PROTOCATECHUIC ACID TRIPHENYLPHOSPHONIUM DERIVATIVES IN HUMAN BREAST CANCER CELLS: POSSIBLE MECHANISM AND BIOENERGETIC IMPLICATIONS
1,3-Disubstituted-5-nitroindazole derivatives are inhibitors and subversive substrates of trypanothione reductase from Trypanosoma cruzi
Assessment of the redox cycling properties of nitrocompounds using a superoxide-dependent pyrogallol red bleaching assay
Protective effect of various polyphenols against mitochondrial dysfunction induced by indomethacin in caco-2 cells
SELECTION OF STRAINS OF LACTOBACILLI AND BIFIDOBACTERIA WITH PROBIOTIC POTENTIAL
Antioxidant versus pro-oxidant effects of thio- amino acids in their interaction with copper ions: In vitro studies
Cross-talk between iron and GSH homeostasis in neuronal cells

BookSection (3)

Evaluation of the antioxidant capacity of food samples: a chemical examination of the oxygen radical absorbance capacity assay
Antioxidantes en verduras y frutas en: Los colores de la salud. 3 Verduras y 2 Frutas al día
Generation of Superoxide by the Interaction Between Mercury Ions and Endogenous Thiols

ConferencePaper (4)

Antioxidant Content and Activity in Different Structures of Five Apple Cultivars Grown in Chile
Antioxidants in chilean berries
Slow and fast-reacting antioxidants from berries: Their evaluation through the FRAP (ferric reducing antioxidant power) assay
Slow and fast-reacting. antioxidants from berries: Their evaluation through the FRAP (Ferric reducing antioxidant power) assay

EditorialMaterial (1)

Effects of copper ions on the free radical-scavenging properties of homocysteine: Implications of a complex formation

Review (3)

Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions
Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi
Boldine and its antioxidant or health-promoting properties
108
Hernan Speisky

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

36
Camilo López

prof. Asociado

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

19
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

12
Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Edgar Pastene

Profesor

Ciencias Básias

Universidad del Bío-Bío

Chillán, Chile

7
Elias Atala

Project Manager

Naturex- Chile botanics division

Santiago, Chile

6
ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

6
Guillermo Figueroa

Profesor Asociado

Laboratorio: Microbiología de Alimentos y Probióticos

INTA, Universidad de Chile

Santiago, Chile

5
Raquel Bridi

Profesor Asistente

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Ricardo Uauy

Professor

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Germán Barriga

Asociado

Quimica

Universidad Metropolitana de Ciencias de la Educación

Ñuñoa, Chile

3
EVA DORTA

Investigador Asociado

Química-Física

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Gloria Montenegro

Profesor Titular

Departamento Ciencias Vegetales

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
CAROLINA JULLIAN

Profesor Asociado

Quimica Organica y Fisicoquimica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

2
María Mizgier

Postdoctorate

Universidad de Los Andes

Santiago, Chile

2
Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

2
Ricardo Simpson

Professor

Chemical and Environmental Engineering Department

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

VALPARAISO, Chile

2
Apolinaria García

Investigador

Microbiology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Fernando Mendizabal

Full Professor

Chemistry

UNIVERSIDAD DE CHILE - FACULTAD DE CIENCIAS

Santiago, Chile

2
MONICA ANTILEN

Profesor Asociado

quimica Inorganica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

2
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

2
Juan Squella

Académico

Química Orgánica y Físico Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Claudia Mardones

Académica

Departamento Análisis Instrumental

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Pamela Morales

Docente

Nutrición y Dietética

Universidad Bernardo O`Higgins

Santiago, Chile

1
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

1
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Valenzuela

Profesor Asociado

Nutrición

Universidad de Chile

Santiago, Chile

1
Maria Soledad Ureta

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carola Vergara

Profesor Asociado

Departamento de Análisis Instrumental

Universidad de Concepción

Concepcion, Chile

1
Jocelyn Fuentes

JEFA DEL LABORATORIO DE ANTIOXIDANTES

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Daniela Andrade

academico

Universidad Austral de Chile

puerto montt , Chile

1
Fernanda Perez

Investigadora senior principal

Síntesis orgánica

Ientropia SPA

Santiago, Chile

1
Claudia Carvallo

Investigadora de Centro de investigación en Gerontología Aplicada

Biología

Universidad Santo Tomás

Santiago, Chile

1
Juan Guerrero

ACADEMICO

QUÍMICA DE LOS MATERILAES

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
PAOLA CACERES

ACADEMICO

NUTRICION

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Ady Giordano

Profesor Asistente

Química

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Almonacid

Profesor Titular

Departament of Chemical and Environmental Engineering

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

1
Eduardo Pino

Acádemico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Jorge Rodriguez

Professor

Department of Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

La Florida, Chile

1
Paola Navarrete

Associate Professor

INTA

Universidad de Chile

Santiago, Chile

1
Julio Salazar

Médico

Neurología

Unidad de Neurología, Hospital San José

Santiago, Chile

1
Loreto Muñoz

Profesora titular

Escuela de Ingenieria

Universidad Central de Chile

Santiago, Chile, Chile

1
Mónica Andrews

INTA

Santiago, Chile

1
Miguel Ángel Rincón

Académico profesor asociado

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS

Santiago, Chile

1
Carla Delporte

Profesor titular

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD CIENCIAS QUÍMICAS Y FARMACÉUTICAS

SANTIAGO, Chile

1
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Francisco Valenzuela

Farmacovigilancia de vacunas

ISP

Santiago, Chile

1
Loreto Muñoz

Academic - researcher

Universidad Central de Chile

Santiago, Chile

1
Maria Angelica Fellenberg

profesor asociado

Pontificia Universidad Católica de Chile

Santiago, Chile