Man

Bruce Kennedy Cassels Niven

Profesor Titular

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

Líneas de Investigación


Quí­mica orgánica; Quí­mica medicinal; Química de productos naturales; Agonistas y antagonistas de monoaminérgicos; Inhibidores de monoaminooxidasas; Antioxidantes; Compuestos antiproliferativos en cáncer; Hierro en enfermedades neurodegenerativas

Educación

  •  Química, Universidad de Buenos Aires. Argentina, 1966

Experiencia Académica

  •   Profesor Titular Part Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Chile

    2005 - A la fecha

  •   Profesor Titular Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    1990 - 2005

  •   Profesor Full Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Ingeniería

    Santiago, Chile

    1967 - 1982

  •   Profesor Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    1988 - 1990

  •   Professeur Associé Full Time

    Université de Paris XI

    Farmacia

    Châtenay-Malabry, Francia

    1986 - 1988

  •   Visiting Scientist Full Time

    Ludwig-Maximilian-Universität München

    Ciencias

    Munich, Alemania

    1985 - 1986

  •   Professeur Associé Full Time

    Université de Paris XI

    Farmacia

    Châtenay-Malabry, Francia

    1984 - 1985

  •   Visiting Lecturer Full Time

    State University of New York - Stony Brook

    Stony Brook, NY, Estados Unidos

    1983 - 1984

Formación de Capital Humano


24 tesis de doctorado
8 tesis de maestría
número indeterminado de tesis de pregrado


Difusión y Transferencia


Participación en programa "Ciencia al Día" de la Facultad de Ciencias de la Universidad de Chile


Premios y Distinciones

  •   Cátedra Presidencial en Ciencias

    Presidencia de la República de Chile

    Chile, 1996

    Financiamiento adicional para las investigaciones del titular


 

Article (272)

Amphetamine derivatives as monoamine oxidase inhibitors
Boldine inhibits the alveolar bone resorption during ligature‐induced periodontitis by modulating the Th17/Treg imbalance
Dibenzofuran annulated 1-azepines: Synthesis and cytotoxicity
Dibenzofuranylethylamines as 5-HT2A/2C Receptor Agonists
5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines
Alkaloids of the Cactaceae The Classics
Antihyperalgesic Activity of Quillaic Acid Obtained from Quillaja saponaria Mol.
Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs
Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA (Ecstasy) in Rats and Preserves Affinity for the Serotonin Transporter (SERT)
Boldo, Its Secondary Metabolites and their Derivatives
Theoretical Study of the Antioxidant Activity of Quercetin Oxidation Products
Variation of Secondary Metabolites in the Aerial Biomass of Cryptocarya alba
Dark Classics in Chemical Neuroscience: Mescaline
Telomerase Inhibition by a New Synthetic Derivative of the Aporphine Alkaloid Boldine
Variation of the alkaloid content of Peumus boldus (boldo)
Functional roles of T3.37 and S5.46 in the activation mechanism of the dopamine D1 receptor
Neuroprotective Effect of a New 7,8-Dihydroxycoumarin-Based Fe2+/Cu2+ Chelator in Cell and Animal Models of Parkinson's Disease
Synthesis, scope, H-1 and C-13 spectral assignments of isomeric dibenzofuran carboxaldehydes
Theoretical insights into the regioselectivity of a Pictet-Spengler reaction: Transition state structures leading to salsolinol and isosalsolinol
(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake.
Analysis of 25 C NBOMe in Seized Blotters by HPTLC and GC-MS
Cycloalkylthiophenylisopropylamine derivatives are better monoamine oxidase inhibitors than their open chain analogues.
PHYTOCHEMICAL ANALYSIS OF ALKALOIDS FROM THE CHILEAN ENDEMIC TREE CRYPTOCARYA ALBA
Simple and efficient synthesis of various dibenzofuran carbaldehydes.
Analysis of a New Potent Hallucinogen, 25-B-NBOMe, in Blotters by High-Performance Thin-Layer Chromatography
Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP plus /MPTP-Lesioned Dopaminergic Neurons
Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition
The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death
2-Phenylaminonaphthoquinones and related compounds=> Synthesis, trypanocidal and cytotoxic activities
A coumarinylaldoxime as a specific sensor for Cu2+ and its biological application
Coumarin-Based Fluorescent Probes for Dual Recognition of Copper(II) and Iron(III) Ions and Their Application in Bio-Imaging
Coumarins isolated from Esenbeckia alata (Rutaceae)
Substituent effects on reactivity of 3-cinnamoylcoumarins with thiols of biological interest
Synthesis of coumarin derivatives as fluorescent probes for membrane and cell dynamics studies
SYNTHESIS OF N-(HALOGENATED) BENZYL ANALOGS OF SUPERPOTENT SEROTONIN LIGANDS
SYNTHESIS OF N-(HALOGENATED) BENZYL ANALOGS OF SUPERPOTENT SEROTONIN LIGANDS
Annulation of substituted anthracene-9,10-diones yields promising selectively antiproliferative compounds
Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe2+
In vivo anti-inflammatory assessment of an aqueous extract of Quillaja saponaria Mol., its hydrolysate, and sapogenin formulations.
Synthesis and antiplasmodial activity of some 1-azabenzanthrone derivatives
Varenicline and cytisine=> two nicotinic acetylcholine receptor ligands reduce ethanol intake in University of Chile bibulous rats
Why is quercetin a better antioxidant than taxifolin? Theoretical study of mechanisms involving activated forms
1H and 13C NMR spectral assignments and X-ray crystallography of 4,5,8,12b-TETrahydro-isoindolo[1,2-a]isoquinoline and derivatives
A selective fluorescent probe for the detection of mercury (II) in aqueous media and its applications in living cells
Design and synthesis of a new coumarin-based 'turn-on' fluorescent probe selective for Cu+2
Nucleophilic reactivity of biothiols toward coumarin-based derivatives containing a chalcone moiety
Nucleophilic reactivity of biothiols toward coumarin-based derivatives containing a chalcone moiety
Salsolinol and isosalsolinol: Condensation products of acetaldehyde and dopamine. Separation of their enantiomers in the presence of a large excess of dopamine
STRUCTURAL REASSIGNMENT OF EPIERYTHRATIDINE, AN ALKALOID FROM Erythrinafusca, BASED ON NMR STUDIES AND COMPUTATIONAL METHODS
Synthesis and evaluation of N-1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands
¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF 4,5,8,12b-TETRAHYDRO-ISOINDOLO[1,2 -α ]ISOQUINOLINE AND DERIVATIVES
Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004-2009
Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice
Crystal structure of (1R,5S)-9-nitro- 1,2,3,4,5,6-hexahydro-1,5- methanopyrido[1,2-A][1,5]diazocin-8-One (9-Nitrocytisine), C 11H 13O 3N 3
Crystal structure of (1R,5S)-9-nitro- 1,2,3,4,5,6-hexahydro-1,5- methanopyrido[1,2-A][1,5]diazocin-8-One (9-Nitrocytisine), C11H 13O3N3
HYDROGEN-BONDED SUPRAMOLECULAR ARRAY IN THE CRYSTAL STRUCTURE OF ETHYL 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLATE MONOHYDRATE
The development of a fluorescence turn-on sensor for cysteine, glutathione and other biothiols. A kinetic study
Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors
Antifungal activity of saponin-rich extracts of Phytolacca dioica and of the sapogenins obtained through hydrolysis
Behavioral Profiles in Rats Distinguish Among "Ecstasy," Methamphetamine and 2,5-Dimethoxy-4-Iodoamphetamine: Mixed Effects for "Ecstasy" Analogues
In silico characterization of cytisinoids docked into an acetylcholine binding protein
Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats
Molecular determinants for competitive inhibition of ?4?2 nicotinic acetylcholine receptors
Molecular Determinants for Competitive Inhibition of alpha 4 beta 2 Nicotinic Acetylcholine Receptors
Synthesis of Lakshminine and Antiproliferative Testing of Related Oxoisoaporphines
In vivo effects of 3-iodocytisine=> Pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites
Molecular modeling of the ?9?10 nicotinic acetylcholine receptor subtype
Molecular modeling of the alpha 9 alpha 10 nicotinic acetylcholine receptor subtype
Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors
SYNTHESIS OF A-RING-SUBSTITUTED 5,6,8,12B-TETRAHYDROISOINDOLO[1,2-A]ISOQUINOLIN-8-ONES
In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives=> Implications for Parkinson's Disease
Quantum-chemical, NMR and X-ray diffraction studies on (+/-)-1-[3,4-(methylenedioxy)phenyl]-2-methylaminopropane
Quantum-chemical, NMR and X-ray diffraction studies on (±)-1-[3,4-(methylenedioxy)phenyl]-2-methylaminopropane
Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers
Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)(2A) and 5-HT2C receptors
Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives=> Insights from molecular modeling studies
?4?2 nicotinic receptors with high and low acetylcholine sensitivity: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine
alpha 4 beta 2 nicotinic receptors with high and low acetylcholine sensitivity=> Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine
C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists
Characterization of mitochondrial iron uptake in HepG2 cells
Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)-anthracenone derivatives on tumor cell respiration
Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture=> Effects of cytisine and its bromo derivatives
N-substitution and ?1-adrenergic receptor affinity of laudanosine analogues
Neurochemical and behavioural characterisation of alkoxyamphetamine derivatives in rats
SYNTHESIS OF 2-ARYL-1,3-PROPANEDIAMINES USING A ONE-POT KNOEVENAGEL-MICHAEL SEQUENCE
Topical anti-inflammatory activity of 2 alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae
Topical anti-inflammatory activity of 2?-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae
8-NH2-boldine, an antagonist of alpha(1A) and alpha(1B) adrenoceptors without affinity for the alpha(1D) subtype: Structural requirements for aporphines at alpha(1)-adrenoceptor subtypes
A CONVENIENT, RENEWABLE SOURCE OF THE ANXIOLYTIC PROAPORPHINE ALKALOID GLAZIOVINE=> DUGUETIA VALLICOLA LEAVES
Crystal structure of isotetrandrine, C38H42N 2O6
Crystal structure of isotetrandrine,C38H42N2O6
Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors
Structure-affinity relationships of halogenated predicentrine and glaucine derivatives at D-1 and D-2 dopaminergic receptors=> halogenation and D-1 receptor selectivity
Structure-affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: Halogenation and D1 receptor selectivity
Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: Biological activities, CoMFA analysis, and active site modeling
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT 2A receptor antagonists in Xenopus laevis oocytes
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes
Analgesic and behavioral effects of amphetamine enantiomers, p-methoxyamphetamine and n-alkyl-p-methoxyamphetamine derivatives
Effects of natural flavones and flavonols on the kinase activity of Cdk5
GEOMETRICAL ISOMERISM IN ?-NITROSTYRENES: PREFERRED CONFORMATIONS OF (E)- AND (Z)- 1-(4-METHYLTHIOPHENYL)-2-NITROBUTENES
MAO inhibition by arylisopropylamines=> the effect of oxygen substituents at the beta-position
Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha(1)-adrenoceptor subtypes
A two-step method for the preparation of homochiral cathinones
An expedient synthesis of unusual oxoisoaporphine and annelated quinoline derivatives
Complete H-1 and C-13 NMR spectral assignment of hydrogenated oxoisoaporphine derivatives
Complete structural and spectral assignment of oxoisoaporphines by HMQC and HMBC experiments
Crystal structure of 2-[(3,4-dimethoxy)-phenethyl-3-(3,4-dimethoxy)- phenethylamino]-2,3-dihydro-isoindol-1-one, C28H32N 2O5
Crystal structure of 3-[(3-oxo-1,3-dihydro-isobenzofuran-1-yl)- phenethylamino]-2-phenethyl-2,3-dihydro-isoindol-l-one, C28H 28N2O3
Crystal structure of 5-methoxy-2,3-dihydro-7H-dibenzo[de,h]quinolin-7-one, C17H13O2
Effects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice
Emerging therapeutic approaches for Alzheimer's disease Enfoques terapéuticos emergentes para la enfermedad de Alzheimer
Enfoques terapéuticos emergentes para la enfermedad de Alzheimer.
Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes
Monoamine oxidase inhibitory properties of optical isomers and N-substituted derivatives of 4-methylthioamphetamine
Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action
Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT 2A and 5-HT 2C receptors
Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptors
Effects of 4,4-dimethyl-5,8-dihydroxynaphtalene-1-one and 4,4-dimethyl-5,8-dihydroxytetralone derivatives on tumor cell respiration
Effects of the plant alkaloid tetrandrine on human nicotinic acetylcholine receptors
New heterocyclic skeletons derived from the aporphine alkaloid boldine
S-oxidation products of alkylthioamphetamines
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities
Activity of cytisine and its brominated isosteres on recombinant human alpha 7, alpha 4 beta 2 and alpha 4 beta 4 nicotinic acetylcholine receptors
Computational study on the conformations of dopamine, its ?- and ortho-methylated derivatives and their N-protonated forms
Computational study on the conformations of dopamine, its alpha- and ortho-methylated derivatives and their N-protonated forms
Differential incorporation of L- and D-N-acyl-1-phenyl-d(5)-2-aminopropane in a cesium N-dodecanoyl-L-alaninate cholesteric nematic lyomesophase
Electron spin resonance studies and theoretical quantum calculations of free radicals generated from anthracenetrione by electrochemical and microsomal reduction
Heterogeneous catalysts in the preparation of 2-aryl-1,3-dinitropropanes from ?-nitrostyrenes or benzaldehydes
Heterogeneous catalysts in the preparation of 2-aryl-1,3-dinitropropanes from beta-nitrostyrenes or benzaldehydes
Oxazine- and oxazole-fused derivatives of the alkaloid boldine and their complete structural and spectral assignments by HMQC and HMBC experiments
ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT(2a) and 5-HT(2c) receptor agonist
ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT2a and 5-HT2c receptor agonist
Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones
Halogenated boldine derivatives with enhanced monoamine receptor selectivity
Phylogenetic and biogeographic aspects of Sophora sect. Edwardsia (Papilionaceae)
Preparation of dopaminergic N-alkyl-benzyltetrahydroisoquinolines using a 'one-pot' procedure in acid medium
A novel route to 5,7-dimethoxy-6-hydroxyflavone
Complete assignment of the 13C NMR spectra of a series of 5,8-disubstituted 4,4-dimethylanthracene-1,9,10(4h)-triones
CRYSTAL STRUCTURES OF (E)-1-(3,4,5-TRIMETHOXYPHENYL)-2-NITROETHENE AND (E)-1-(3,4,5-TRIMETHOXYPHENYL)-2-NITROPROPENE
Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission
Effects of some ?-carboline alkaloids on intact Trypanosoma cruzi epimastigotes
Total synthesis of annofolin
13C-NMR and theoretical studies of internal rotation in methylated anilines
? 1-Adrenergic and 5-HT 2-serotonergic effects of some ?-alkoxy-?-phenylethylamines on isolated rat thoracic aorta
Antipyretic, hypothermic and antiinflammatory activities and metabolites from Solanum ligustrinum Lood.
Cardiovascular effects of plant secondary metabolites norarmepavine, coclaurine and norcoclaurine
Crystal structure of 7-bromo-5,8-dihydroxy-4,4-dimethyl-4H-naphthalen-1-one
Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine
The regioselective bromination of 4,4-dimethyl-5,8-dihydroxy-4H- naphthalen-1-one
Antiinflammatory and antipyretic metabolites of Acaena splendens
Antiinflammatory and antipyretic metabolites of Acaena splendens.
Lysozyme inactivation by free radicals can occur independently of reactive carbonyl formation
Monoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives. Structure-activity relationships
Protective effect of boldine in experimental colitis
(S)-1,10-dimethoxy-2,9-dihydroxy-aporphinium chloride (boldine hydrochloride), C 19H 22NO 4 +.Cl -
(±)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors
6-bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids
Anti-inflammatory and antipyretic activities of Cuscuta chilensis, Cestrum parqui and Psoralea glandulosa.
Antiinflammatory and antipyretic activities of Cuscuta chilensis, Cestrum parqui and Psoralea glandulosa
Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes
Phylogenetic relationships among Chilean Sophora species
Cyclobakuchiols A and B from Psoralea glandulosa.
Efecto de un extracto seco de boldo sobre el tránsito intestinal oro-cecal en voluntarios sanos.
Structure-antioxidative activity relationships in benzylisoquinoline alkaloids.
The preparation of potentially psychoactive -alkoxyphenethylamines.
Anti-inflammatory and antipyretic effects of boldine.
Boldo and boldine: an emerging case of natural drug development.
Constituents of Centaurea chilensis.
Constituents of Senecio hollermayerii.
Dimethylaminophenethylamine, a sensitive, highly selective, electrochemically detectable monoamine oxidase-B substrate.
Infrared spectra of nitrostyrene derivatives
Monoamine oxidase inhibitory effects of some 4-aminophenethylamine derivatives.
Nitro radical anion formation from nitro-substituted amphetamine derivatives.
Some fluoro and nitro analogues of hallucinogenic amphetamines.
Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi.
-Adrenergic and 5-HT2-serotonergic effects of some -phenylethylamines on isolated rat thoracic aorta.
(R)- and (S)-coclaurine from the bark of Peumus boldus.
Determination of boldine in plasma by HPLC.
Electrochemical oxidation of methylenedioxyamphetamines.
Flavonoids from the twigs of Eucryphia glutinosa.
Preliminary voltammetric data for the oxidation of 4-methylaminophenethylamine derivatives in buffer and in aprotic solvents.
Structure of (E)-1-(4-methoxyphenyl)-2-nitropropene.
The methylation of boldine with diazomethane.
Two new antiinflammatory elemanolides from Centaurea chilensis.
Cathodic behavior of 4,5-dimethoxy-2-nitroamphetamine.
Electrochemical study of some 2,5-dimethoxyamphetamine derivatives.
One- and two-dimensional NMR in the structure determination of 3-acetoxy-17,21-epoxyhopane from Centaurea chilensis.
Regioselective ring-opening by propanethiolate of 1,3-benzodioxoles with electron-withdrawing substituents.
The action of the psychoactive drug 2C-B on isolated rat thoracic aorta.
Antioxidant properties of the alkaloid boldine in systems undergoing lipid peroxidation and enzyme inactivation.
Estructura cristalina del (E)-1-(4-dimetilaminofenil)-2-nitropropeno.
Inhibitory effect of boldine on fish oil oxidation.
Acerca de la bromación del 2,5-dimetoxibenzaldehido - Una síntesis corta de 4-alquiltio-2,5-dimetoxibenzaldehidos.
An aryltetralin lignan from Persea lingue.
Dibenzyl trisulfide and trans-N-methyl-4-methoxyproline from Petiveria alliacea.
Carbon-13 nmr spectra of azafluorenones.
Steroids, a lignan and a flavonoid from Centaurea melitensis.
Bisbenzylisoquinoline biosynthesis in Berberis stolonifera cell cultures.
Guaianolides from Centaurea chilensis and Centaurea floccosa.
Spectral properties of ring-C-oxygenated 4-azafluorenes and 4-azafluorenones. The structures of natural onychine derivatives.
A quantum-chemical and experimental study on the hallucinogen (±)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON)
Alcaloïdes de Annona hayesii.
Alkaloids of Alphonsea sclerocarpa.
Azafluorenones from Oxandra cf.major and biogenetic considerations.
Bisbenzylisoquinoline alkaloids in Berberis cell cultures.
Fate of ingested aristolochic acids in Battus archidamas.
Kinabaline and the aporphinoid biogenesis of azaanthracene and azafluorene alkaloids.
Revised structures of the alkaloids from Guatteria dielsiana.
Revision of the early steps of reticuline biosynthesis.
The 13C-NMR spectra of 1,2,10-trioxygenated aporphines.
Artavenustine, a catecholic berbine from Artabotrys venustus.
Azahomoaporphines: a new heterocyclic skeleton from Annonaceae.
Electronic structure and serotonin receptor binding affinity of 7-substituted tryptamines.
Spectroscopic characterization of a new hallucinogen: 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON).
A reevaluation of psychotomimetic amphetamine derivatives in humans.
Analysis of a Maasai arrow poison.
Bisbenzylisoquinoline alkaloids of Laurelia sempervirens.
Dímeros de proaporfina-1-benciltetrahidroisoquinolina en tallos de Berberis hakeoides.
(+)-9-Hydroxymatrine from Sophora macrocarpa.
Aristolochic acids in Aristolochia chilensis and the Aristolochia-feeder Battus archidamas (Lepidoptera).
Mass spectrometry of aristolochic acids.
The rhoeadine alkaloids.
Additional alkaloids from Laurelia philippiana and L. novae-zelandiae.
Aristolochic acids in Aristolochia chilensis.
Aurapten and flindersine from Zanthoxylum coco.
Chilenine: an isoindolobenzazepine alkaloid.
Leaf alkaloids of Sophora macrocarpa.
Síntesis de 1-aril-2-nitroalquenos antitumorales.
The use of nuclear magnetic resonance nuclear Overhauser enhancements in the structural elucidation of bisbenzylisoquinoline alkaloids.
Calafatimine, a new imino bisbenzylisoquinoline alkaloid.
(E)-1-(4'-hydroxy-3'-methoxyphenyl)-2-nitropropene, C10H11NO4
A simple relationship between stereostructure and specific rotation for the bisbenzylisoquinolines.
The 13C-NMR spectra of cyclopeptide alkaloids.
Aislamiento de dos flavonoides y una nueva cromona de la corteza de Eucryphia cordifolia.
Aislamiento de soforicósido de Schinus latifolius.
Calafatine, an unusual bisbenzylisoquinoline alkaloid.
Coumarins and cinnamic acid from Gymnophyton isatidicarpum.
Metabolitos secundarios de Berberis buxifolia.
N,O-Diacetyl-4-hydroxynornantenine.
4-Hydroxynornantenine, a 4-hydroxylated noraporphine.
Alkaloid chemosystematics, chemotaxonomy and biogenesis in the Atherospermataceae.
Las conformaciones de la zizifina D en solución
Leaf alkaloids of Fagara mayu.
Estudio preliminar de los alcaloides de Annona cherimolia.
Weak bases of Laurelia novae-zelandiae. A cautionary note on oxoaporphine nmr assignments.
(+)-Reticulina en Cryptocarya alba.
Alcaloides de Laurelia sempervirens y Laurelia philippiana.
Cumarinas de las hojas de Fagara mayu.
Actividad biológica de Solanum malacoxylon Sendtner en ratas
Aislamiento de diosgenina de Solanum tomatillo.
Alkaloids from Fagara mayu bark.
Cyclopeptide alkaloids from Zizyphus oenoplia.
Zizyphine-F and G, new cyclopeptide alkaloids from Zizyphus oenoplia Mill.
One-step synthesis of 1,1-dimethyl- and 1-spirocycloalkano-1,2,3,4-tetrahydro--carbolines.
Triterpene constituents of Kageneckia oblonga.
Isolation of candicine from Trichocereus chiloensis.
Potential psychotomimetics. New bromoalkoxyamphetamines.
Principios activos de brebajes alucinógenos del Ucayali y del Amazonas peruano.
Tribal and urban healing with hallucinogenic beverages in Amazonian Peru
Análisis de los aceites de semillas de Sophora macrocarpa y de Sophora tetraptera, sensu Reiche.
Principios tóxicos de Solanum malacoxylon Sendtner. I. Acción de fracciones separadas por extracción con solventes selectivos sobre el metabolismo fosfo-cálcico y tejidos blandos del conejo
On the resolution of pseudolaudanine and the configuration of its enantiomers.
Resolution of O-benzoyl-(±)-codamine: L(+)- and D-(-)-codamines.
1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES: ¹H NMR CONFORMATIONAL STUDIES AND ROTATIONAL BARRIERS
A CONVENIENT, RENEWABLE SOURCE OF THE ANXIOLYTIC PROAPORPHINE ALKALOID GLAZIOVINE: DUGUETIA VALLICOLA LEAVES
CATHODIC BEHAVIOR OF 2,3-DIHYDROOXOISOAPORPHINES COMPORTAMIENTO CATÓDICO DE 2,3-DIHIDRO-OXOISOAPORFINAS
Characterization of mitochondrial iron uptake in HepG2 cells
Enfoques terapéuticos emergentes para la enfermedad de Alzheimer
GEOMETRICAL ISOMERISM IN β-NITROSTYRENES: PREFERRED CONFORMATIONS OF (E)- AND (Z)- 1-(4-METHYLTHIOPHENYL)-2-NITROBUTENES
N-SUBSTITUTION AND á1-ADRENERGIC RECEPTOR AFFINITY OF LAUDANOSINE ANALOGUES
SYNTHESIS OF 2-ARYL-1,3-PROPANEDIAMINES USING A ONE-POT KNOEVENAGEL-MICHAEL SEQUENCE

Abstract (2)

Cytisine and derivatives partially prevents the striatal dopamine decrease in an experimental model of Parkinson's disease
Effects of halogenated derivatives of glaucine on the different isolated cyclic nucleotide phosphodiesterase isoenzymes

BookSection (5)

Alkaloids from the genus Duguetia
Propiedades antioxidantes, citoprotectoras y relacionadas de compuestos aporfínicos.
Synthesis of peptide mimetics and their building blocks
Recent developments in the chemistry and pharmacology of boldo and boldine.
Alkaloids from Guatteria

ConferencePaper (1)

Synthesis and evaluation of N 1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands

Errata (2)

Erratum: The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death (Biochemical and Biophysical Research Communications (2015) 463:4 (787-792) DOI:10.1016/j.bbrc.2015.06.014)
Erratum: Hydrogen-bonded supramolecular array in the crystal structure of ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate monohydrate (Journal of the Chilean Chemical Society (2011) 56:1 (546-548))

Letter (1)

Distinguishing rotamers in N-trifluoroacetyl-3-benzazepine derivatives

Proyecto (19)

DISEÑO Y SÍNTESIS DE LIGANDOS DIRIGIDOS A UN NUEVO RECEPTOR NICOTÍNICO DE ACETILCOLINA (RNACO) HETEROMÉRICO ALFA7BETA2
MOLECULAR DETERMINANTS OF AFFINITY AND EFFICACY IN SUPERPOTENT 5-HT2 RECEPTOR LIGANDS
TOTAL SYNTHESIS OF POTENTIALLY BIOACTIVE DIBENZOFURAN DERIVATIVES=> THE ALKALOID EPIMEDIPHINE, NOVEL DIBENZOFURAN EMBEDDED APORPHINES AND MEDIUM-RING AZAHETEROCYCLES
Bases para el aprovechamiento sustentable de las hojas medicinales de Peumus boldus y Cryptocarya alba
DISRUPTION OF THE OXIDATIVE STRESS-IRON ACCUMULATION CYCLE AS A STRATEGY FOR DECREASING DOPAMINERGIC NEURON DEATH IN EXPERIMENTAL MODELS OF PARKINSON S DISEASE.
ESTUDIO DE FOTOISOMERIZACION CIS-TRANS Y COMPORTAMIENTO FOTOCROMICO DE UN NUEVO MATERIAL FOTOSENSIBLE DERIVADO DE DIAZENILBENZOTIOFENO.
HALOGEN BONDS IN DRUG DESIGN=> EXAMPLES IN THE MONOAMINERGIC AREA
SYNTHESIS OF ENANTIOMERICALLY PURE TETRAHYDROISOQUINOLINES WITH A POTENTIAL ROLE IN THE BIOCHEMICAL BASIS OF ALCOHOLISM.
HIGHLY FUNCTIONALIZED NATURAL PENTACYCLIC TRITERPENOIDS=> STRUCTURAL MODIFICATION AND MEDICINAL CHEMISTRY
PROSPECTIVE BEHAVIOURAL CHARACTERIZATION OF PUTATIVE ENTACTOGENIC PHENYLALKYLAMINES WITH POSSIBLE APPLICATION IN PSYCHOTERAPY.
MONOAMINE OXIDASE INHIBITORS. bINDING MODE, RATIONAL DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION BASED ON THE ENZYMES CRYSTAL STRUCTURES
DESIGN, SYNTHESIS AND EVALUATION OF POSSIBLE SUBTYPE-SELECTIVE AGONITS AND ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS.
DESIGN, SYNTHESIS AND EVALUATION OF POSSIBLE SUBTYPE-SELECTIVE AGONITS AND ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS.
BASES CELULARES Y MOLECULARES DE LOS PROCESOS NEURODEGENERATIVOS=> UNA VISION INTEGRATIVA DESDE LA PERSPECTIVA DEL CITOESQUELETO NEURONAL
PHENETHYLAMINE AS FOR EXPLORING THE MAO ACTIVE SITE
DISENO RACIONAL DE INHIBIDORES Y SUSTRATOS SUBVERSIVOS DE LA TRIPANOTION REDUCTASA
PROPIEDADES CITOPROTECTORAS Y DESTINO METABOLICO DE LA BOLDINA=> UN ANTIOXIDANTE DE ORIGEN NATURAL.
RELACIONES ENTRE ESTRUCTURA QUIMICA Y ACTIVIDAD FARMACOLOGICA DE MOLECULAS QUE ACTUAN SOBRE LA NEUROTRANSMISION MONOAMINERGICA.
DETERMINACION MECANICO-CUANTICA Y COMPUTACIONAL DE LA ESTRUCTURA DE RECEPTORES Y FARMACOFOROS DE INTERES FARMACOLOGICO.

Review (4)

Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia?
Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors
Alkaloids from the genus Duguetia.
From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research
230
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

8
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

7
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

4
Carla Delporte

Profesor titular

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD CIENCIAS QUÍMICAS Y FARMACÉUTICAS

SANTIAGO, Chile

4
Gerald Zapata

DEPARTAMENTO DE QUÍMICA INORGÁNICA Y ANALÍTICA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS UNIVERSIDAD DE CHILE

Santiago, Chile

3
Cristian Tirapegui

Académico

Universidad Autonoma de Chile

Santiago, Chile

3
Cristian Suárez

Profesor Investigador

Universidad del Desarrollo

Santiago, Chile

3
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Iriux Almodóvar

Académico

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

2
Vicente Castro

Associate Professor

Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

Santiago, Chile

2
osvaldo yañez

Post Doctorado

Departamento de Ciencias y Tecnología Farmacéutica

Universidad de Chile

Santiago, Chile

2
Hernan Speisky

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

2
Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

2
Edwar Fuentes

Académico jornada completa

Química Inorgánica y Analítica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Maria Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

1
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Claudia Yáñez

académico

Química Orgánica y Físico Química

Universidad de Chile

Santiago, Chile

1
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

1
Ady Giordano

Profesor Asistente

Química

Pontificia Universidad Católica de Chile

Santiago, Chile

1
EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Maria Theoduloz

Planta Profesional

UNIVERSIDAD DE TALCA

Talca, Chile

1
Pabla Aguirre

Asistente de investigación

Biología

Universidad de Chile

Santiago, Chile

1
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Javier Echeverría

Profesor Asistente e Investigador

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago de Chile, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
José Salgado

Assistant Professor

Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

1
Susan Lühr

Profesor Asistente

Química

Universidad de Chile

Santiago, Chile

1
Luis Vilches

Académico

Universidad de Chile

Chile

1
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

1
Paulina Pavez

Associate Professor

Physical Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Monica Acevedo

Profesor Asistente

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
William Tiznado

Full professor

Chemical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Lina Ruiz

Academico Docente Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Pamela Urrutia

Investigador

Biología

Universidad de Chile

Santiago, Chile

1
Edison Osorio

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Maite Rodriguez

Profesor Jornada

Farmacia

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
José Santos

Professor

Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
ANTONIO GALDAMEZ

ASSOCIATE PROFESSOR

CHEMISTRY

DEPARTAMENTO DE QUÍMICA, FACULTAD DE CIENCIA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Sebastián Fuentes

Estudiante postgrado

Farmacología

Universidad de Chile

Santiago, Chile

1
Gloria Montenegro

Profesor Titular

Departamento Ciencias Vegetales

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Natalia Martínez

Investigador Postdoctoral

Química

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

1
Gabriela Valenzuela

Docente

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

1
Patricio Pérez

Asistant Project Scientist

Botany and Plant Science

University of California, Riverside

Riverside, Estados Unidos