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Bruce Kennedy Cassels Niven

Profesor Titular

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

Química orgánica; Química medicinal; Química de productos naturales; Agonistas y antagonistas de monoaminérgicos; Inhibidores de monoaminooxidasas; Antioxidantes; Compuestos antiproliferativos en cáncer; Hierro en enfermedades neurodegenerativas

Química, Universidad de Buenos Aires. Argentina, 1966

Profesor Titular Part Time

UNIVERSIDAD DE CHILE

Ciencias

Chile

2005 - A la fecha
Profesor Titular Full Time

UNIVERSIDAD DE CHILE

Ciencias

Santiago, Chile

1990 - 2005
Profesor Full Time

UNIVERSIDAD DE SANTIAGO DE CHILE

Ingeniería

Santiago, Chile

1967 - 1982
Profesor Full Time

UNIVERSIDAD DE CHILE

Ciencias Químicas y Farmacéuticas

Santiago, Chile

1988 - 1990
Professeur Associé Full Time

Université de Paris XI

Farmacia

Châtenay-Malabry, Francia

1986 - 1988
Visiting Scientist Full Time

Ludwig-Maximilian-Universität München

Ciencias

Munich, Alemania

1985 - 1986
Professeur Associé Full Time

Université de Paris XI

Farmacia

Châtenay-Malabry, Francia

1984 - 1985
Visiting Lecturer Full Time

State University of New York - Stony Brook

Stony Brook, NY, Estados Unidos

1983 - 1984

24 tesis de doctorado
8 tesis de maestría
número indeterminado de tesis de pregrado

Participación en programa "Ciencia al Día" de la Facultad de Ciencias de la Universidad de Chile

Cátedra Presidencial en Ciencias

Presidencia de la República de Chile

Chile, 1996

Financiamiento adicional para las investigaciones del titular


Phytochemical variation of wild and farmed populations of boldo (Peumus boldus Molina) Fuentes-Barros, Gonzalo; Echeverria, Javier; Mattar, Cesar; Liberona, Leonel; Giordano, Ady; Suarez-Rozas, Cristian; Salas-Norambuena, Julio; Gonzalez-Cooper, Antonia; Cassels, Bruce K.; Castro-Saavedra, Sebastian Article ISI JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS (2023)
Reduction of nicotine and ethanol intake in alcohol-preferring (UChB) female rats by the alpha;482 nicotinic acetylcholine receptor partial agonists 5-bromocytisine and cytisine Quintanilla, Maria Elena; Rivera-Meza, Mario; Berrios-Carcamo, Pablo; Cassels, Bruce K. Article ISI DRUG AND ALCOHOL DEPENDENCE (2023)
5-HT2 Receptor Subfamily and the Halogen Bond Promise Fierro, Angelica; Matthies, Douglas J.; Cassels, Bruce K.; Jaque, Pablo; Zapata-Torres, Gerald Article ISI JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)
Structure-antioxidant activity relationships in boldine and glaucine: a DFT study Vasquez-Espinal, Alejandro; Yanez, Osvaldo; Osorio, Edison; Areche, Carlos; Garcia-Beltran, Olimpo; Ruiz, Lina M.; Cassels, Bruce K.; Tiznado, William Article ISI NEW JOURNAL OF CHEMISTRY (2021)
Amphetamine derivatives as monoamine oxidase inhibitors Reyes-Parada M.; Iturriaga-Vasquez P.; Cassels B.K. Article ISI SCOPUS (2020)
Boldine inhibits the alveolar bone resorption during ligature‐induced periodontitis by modulating the Th17/Treg imbalance Cafferata, Emilio A.; Castro?Saavedra, Sebastián; Fuentes?Barros, Gonzalo; Melgar?Rodríguez, Samanta; Rivera, Felipe; Carvajal, Paola; Hernández, Marcela; Cortés, Bastián I.; Cortez, Cristian; Cassels, Bruce K.; Vernal, Rolando Article Journal of Periodontology (2020)
Dibenzofuran annulated 1-azepines: Synthesis and cytotoxicity Yempala T.; Babu T.; Gibson D.; Cassels B.K. Article ISI SCOPUS SYNTHETIC COMMUNICATIONS (2020)
Dibenzofuranylethylamines as 5-HT(2A/2C )Receptor Agonists Yempala T.; Brea J.; Loza M.I.; Matthies D.J.; Zapata-Torres G; Cassels B.K. Article ISI SCOPUS ACS OMEGA (2020)
5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines Toro-Sazo, M; Brea, J; Loza, MI; Cimadevila, M; Cassels, BK Article ISI SCOPUS PLOS ONE (2019)
Alkaloids of the Cactaceae The Classics Cassels, Bruce K. Article ISI SCOPUS NATURAL PRODUCT COMMUNICATIONS (2019)
Antihyperalgesic Activity of Quillaic Acid Obtained from Quillaja saponaria Mol. Arrau, Sylvia; Rodriguez-Diaz, Maite; Cassels, Bruce K.; Valenzuela-Barra, Gabriela; Delporte, Carla.; Barriga, Andres; Miranda, Hugo F. Article ISI SCOPUS CURRENT TOPICS IN MEDICINAL CHEMISTRY (2019)
Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs Suarez-Rozas, C; Simpson, S; Fuentes-Retamal, S; Catalan, M; Ferreira, J; Theoduloz, C; Mella, J; Cabezas, D; Cassels, BK; Yanez, C; Castro-Castillo, V Article ISI SCOPUS Toxicology in vitro : an international journal published in association with BIBRA. (2019)
Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA (Ecstasy) in Rats and Preserves Affinity for the Serotonin Transporter (SERT) Saez-Briones, P; Castro-Castillo, V; Diaz-Veliz, G; Valladares, L; Barra, R; Hernandez, A; Cassels, BK Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)
Boldo, Its Secondary Metabolites and their Derivatives Cassels, Bruce K.; Fuentes-Barros, Gonzalo; Castro-Saavedra, Sebastián Article Current Traditional Medicine (2019)
Theoretical Study of the Antioxidant Activity of Quercetin Oxidation Products VÃ¡squez-Espinal A.; YaÃ±ez O.; Osorio E.; Areche C.; GarcÃa-BeltrÃ¡n O.; Ruiz, L.M.; Cassels B.K.; Tiznado W. Article ISI SCOPUS FRONTIERS IN CHEMISTRY (2019)
Variation of Secondary Metabolites in the Aerial Biomass of Cryptocarya alba Giordano, Ady; Fuentes-Barros, Gonzalo; Castro-Saavedra, Sebastián; González-Cooper, Antonia; Suárez-Rozas, Cristian; Salas-Norambuena, Julio; Acevedo-Fuentes, Williams; Leyton, Felipe; Tirapegui, Cristian; Echeverría, Javier; Claros, Sandra; Cassels, Bruce K. Article ISI SCOPUS NATURAL PRODUCT COMMUNICATIONS (2019)
Dark Classics in Chemical Neuroscience: Mescaline Cassels B.K.; SÃ¡ez-Briones P. Article ISI SCOPUS ACS Chemical Neuroscience (2018)
Telomerase Inhibition by a New Synthetic Derivative of the Aporphine Alkaloid Boldine Noureini, SK; Kheirabadi, M; Masoumi, F; Khosrogerdi, F; Zarei, Y; Suarez-Rozas, C; Salas-Norambuena, J; Cassels, BK Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Variation of the alkaloid content of Peumus boldus (boldo) Fuentes-Barros, G; Castro-Saavedra, S; Liberona, L; Acevedo-Fuentes, W; Tirapegui, C.; Mattar, C; Cassels, BK Article ISI SCOPUS FITOTERAPIA (2018)
Functional roles of T3.37 and S5.46 in the activation mechanism of the dopamine D1 receptor Hugo, Estefanía A.; Cassels, Bruce K.; Fierro, Angélica Article ISI SCOPUS JOURNAL OF MOLECULAR MODELING (2017)
Neuroprotective Effect of a New 7,8-Dihydroxycoumarin-Based Fe2+/Cu2+ Chelator in Cell and Animal Models of Parkinson's Disease 224) Aguirre, P.; García-Beltrán, O.; Tapia, V.; Muñoz, Y.; Cassels, B.K.; Núñez, M.T. Article ISI SCOPUS ACS CHEMICAL NEUROSCIENCE (2017)
Synthesis, scope, H-1 and C-13 spectral assignments of isomeric dibenzofuran carboxaldehydes 223) Yempala, T.; Cassels, B.K. Article ISI SCOPUS MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS (2017)
Theoretical insights into the regioselectivity of a Pictet-Spengler reaction: Transition state structures leading to salsolinol and isosalsolinol Almodovar I.; Rezende M.C.; Cassels B.K.; García-Arriagada M. Article ISI SCOPUS JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2017)
(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake. Quintanilla, ME; Rivera-Meza, M; Berrios-Carcamo, P; Cassels, BK; Herrera-Marschitz, M; Israel, Y Article ISI SCOPUS ADDICTION BIOLOGY (2016)
Analysis of 25 C NBOMe in Seized Blotters by HPTLC and GC-MS Duffau, B; Camargo, C; Kogan, M; fuentes, e; Cassels, BK Article ISI SCOPUS JOURNAL OF CHROMATOGRAPHIC SCIENCE (2016)
Cycloalkylthiophenylisopropylamine derivatives are better monoamine oxidase inhibitors than their open chain analogues. Vilches-Herrera, M.; Fierro, A.; Lühr, S.; Miranda-Sepúlveda, J.; Iturriaga-Vásquez, P.; Reyes-Parada, M.; Cassels, B.K. Article Rev. Farmacol. Chile (2016)
PHYTOCHEMICAL ANALYSIS OF ALKALOIDS FROM THE CHILEAN ENDEMIC TREE CRYPTOCARYA ALBA SEBASTIÁN CASTRO-SAAVEDRA; GONZALO FUENTES-BARROS; Cristian Tirapegui; WILLIAMS ACEVEDO-FUENTES; BRUCE K CASSELS; ANDRÉS BARRIGA; Marcelo Vilches-Herrera Article ISI SCIELO SCOPUS JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2016)
Simple and efficient synthesis of various dibenzofuran carbaldehydes. 222) Yempala, T.; Cassels, B.K. Article ISI SCOPUS SYNTHETIC COMMUNICATIONS (2016)
Analysis of a New Potent Hallucinogen, 25-B-NBOMe, in Blotters by High-Performance Thin-Layer Chromatography Duffau, BE; Camargo C.; Cassels, BK; Kogan M.; Fuentes E. Article ISI SCOPUS Journal of Planar Chromatography - Modern TLC (2015)
Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP plus /MPTP-Lesioned Dopaminergic Neurons Aguirre P.; Mena, NP; Carrasco, CM; Muñoz Y.; Perez-Henriquez, P; Morales, RA; Cassels, BK; Mendez-Galvez, C; Garcia-Beltran, O; Gonzalez-Billault, C; Nunez, MT Article ISI SCOPUS PLOS ONE (2015)
Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition Celis-Barros, C; Saavedra-Rivas L.; Salgado J.C.; Cassels, B.K.; Zapata-Torres, G Article ISI SCOPUS JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2015)
The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death Mena, NP; Garcia-Beltran, O; Lourido F.; Urrutia, PJ; Mena, R; Castro-Castillo, V; Cassels, BK; Nunez, MT Article ISI SCOPUS Biochemical and Biophysical Research Communications (2015)
2-Phenylaminonaphthoquinones and related compounds=> Synthesis, trypanocidal and cytotoxic activities Sieveking I, Thomas P; Estévez JC, Quiñones N; Cuéllar MA, Villena J; Espinosa-Bustos C, Fierro A; Tapia RA, Maya JD; López-Muñoz R, Cassels BK; Estévez RJ, Salas CO. Article Bioorganic & Medicinal Chemistry (2014)
A coumarinylaldoxime as a specific sensor for Cu2+ and its biological application Garcia-Beltran, O; Cassels, B.K.; Mena N.; Núñez M.T.; Yanez, O.; Caballero, J Article ISI SCOPUS TETRAHEDRON LETTERS (2014)
Coumarin-Based Fluorescent Probes for Dual Recognition of Copper(II) and Iron(III) Ions and Their Application in Bio-Imaging Garcia-Beltran, O; Cassels, B.K.; Pérez, C.; Mena N.; Núñez M.T.; Martinez N.P.; Pavez P.; Aliaga M.E. Article ISI SCOPUS SENSORS (2014)
Coumarins isolated from Esenbeckia alata (Rutaceae) Garcia-Beltran, O; Areche, C; Cassels, B.K.; Cuca Suarez L.E. Article ISI SCOPUS BIOCHEMICAL SYSTEMATICS AND ECOLOGY (2014)
Substituent effects on reactivity of 3-cinnamoylcoumarins with thiols of biological interest Aliaga, ME; Tiznado W., Cassels; BK, nunez mt; Millán D., Perez; EG, Garcia-Beltran; O, Pavez Article RSC Adv. (2014)
Synthesis of coumarin derivatives as fluorescent probes for membrane and cell dynamics studies García-Beltrán, O.; Yañez; O.; Caballero, J.; Galdámez; A.; Mena, N.; Nuñez; M.T.; Cassels, B.K. Article European Journal of Medicinal Chemistry (2014)
SYNTHESIS OF N-(HALOGENATED) BENZYL ANALOGS OF SUPERPOTENT SEROTONIN LIGANDS CRISTIAN TIRAPEGUI, MIGUEL A TORO-SAZO Article Journal of the Chilean Chemical Society (2014)
SYNTHESIS OF N-(HALOGENATED) BENZYL ANALOGS OF SUPERPOTENT SEROTONIN LIGANDS Cristian Tirapegui, MIGUEL A TORO-SAZO Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2014)
Annulation of substituted anthracene-9,10-diones yields promising selectively antiproliferative compounds Castro-Castillo, V; Suarez-Rozas, C; Castro-Loiza, N; Theoduloz C., Cassels Article European Journal of Medicinal Chemistry (2013)
Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe2+ Garcia-Beltran, O; Mena, N; Yanez, O; Caballero J., Vargas; V, nunez mt; Cassels, BK Article European Journal of Medicinal Chemistry (2013)
In vivo anti-inflammatory assessment of an aqueous extract of Quillaja saponaria Mol., its hydrolysate, and sapogenin formulations. 27. Rodríguez-Díaz, M.; Correa, O.; Cartagena, C.; Arrau, S.; Cassels, B.K.; Delporte, C. Article J. Life Sci. (2013)
Synthesis and antiplasmodial activity of some 1-azabenzanthrone derivatives Castro-Castillo, V; Suarez-Rozas, C; Pabon, A; Perez, EG; Cassels, BK; Blair, S Article Bioorganic & Medicinal Chemistry Letters (2013)
Varenicline and cytisine=> two nicotinic acetylcholine receptor ligands reduce ethanol intake in University of Chile bibulous rats Sotomayor-Zarate, R; Gysling K, Busto; UE, Cassels; BK, Tampier; L, Quintanilla ME Article PSYCHOPHARMACOLOGY (2013)
Why is quercetin a better antioxidant than taxifolin? Theoretical study of mechanisms involving activated forms Osorio, E; Perez, EG.; Areche, C; Ruiz, LM; Cassels, BK; Florez E.; Tiznado, W Article ISI SCOPUS JOURNAL OF MOLECULAR MODELING (2013)
1H and 13C NMR spectral assignments and X-ray crystallography of 4,5,8,12b-TETrahydro-isoindolo[1,2-a]isoquinoline and derivatives Castro-Castillo, V; Galdamez, A.; Rebolledo-Fuentes, M; Cassels, B.K. Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2012)
A selective fluorescent probe for the detection of mercury (II) in aqueous media and its applications in living cells Garcia-Beltran, O; Mena N.; Berrios T.A.; Castro E.A.; Cassels, B.K.; Núñez M.T.; Aliaga M.E. Article ISI SCOPUS TETRAHEDRON LETTERS (2012)
Design and synthesis of a new coumarin-based 'turn-on' fluorescent probe selective for Cu+2 Garcia-Beltran, O; Mena N.; Friedrich L.C.; Netto-Ferreira J.C.; Vargas V.; Quina F.H.; Núñez M.T.; Cassels, B.K. Article ISI SCOPUS TETRAHEDRON LETTERS (2012)
Nucleophilic reactivity of biothiols toward coumarin-based derivatives containing a chalcone moiety Garcia-Beltran, O; Gonzalez C, Perez; EG, Cassels; BK, Santos; JG, Millán D.; Mena, N; Pavez, P.; Aliaga, ME Article Journal of Physical Organic Chemistry (2012)
Nucleophilic reactivity of biothiols toward coumarin-based derivatives containing a chalcone moiety Garcia-Beltran, O; Cassels, B.K.; González C; Pérez E.G.; Santos J.G.; Millán D.; Pavez P.; Aliaga M.E.; Mena N. Article JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2012)
Salsolinol and isosalsolinol: Condensation products of acetaldehyde and dopamine. Separation of their enantiomers in the presence of a large excess of dopamine de los angeles Juricic M.; Berrios-Carcamo P.A.; Acevedo M.L; Israel, Y; Almodovar, I; Cassels, B.K. Article ISI SCOPUS Journal of Pharmaceutical and Biomedical Analysis (2012)
STRUCTURAL REASSIGNMENT OF EPIERYTHRATIDINE, AN ALKALOID FROM Erythrinafusca, BASED ON NMR STUDIES AND COMPUTATIONAL METHODS Garcia-Beltrán, Olimpo; Soto?Delgado, Jorge; Iturriaga-Vásquez, Patricio; Areche, Carlos; Cassels, Bruce K. Article SCIELO JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2012)
Synthesis and evaluation of N-1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands Pérez E.G.; Cassels, B.K.; Eibl C.; Gundisch D. Article ISI SCOPUS Bioorganic and Medicinal Chemistry (2012)
¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF 4,5,8,12b-TETRAHYDRO-ISOINDOLO[1,2 -α ]ISOQUINOLINE AND DERIVATIVES Castro-Castillo, Vicente; Galdámez, Antonio; REBOLLEDO-FUENTES, MARCO; Cassels, Bruce K. Article SCIELO JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2012)
Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004-2009 Cassels, BK; Asencio M. Article ISI SCOPUS Phytochemistry Reviews (2011)
Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice Arrau, S; Delporte C.; Cartagena, C; Rodriguez-Diaz, M; Gonzalez P.; Silva, X.; Cassels, BK; Miranda, HF Article ISI SCOPUS Journal of Ethnopharmacology (2011)
Crystal structure of (1R,5S)-9-nitro- 1,2,3,4,5,6-hexahydro-1,5- methanopyrido[1,2-A][1,5]diazocin-8-One (9-Nitrocytisine), C 11H 13O 3N 3 Galdamez, A.; Gutierrez-Hernandez, M; Cassels, B.K.; Saez-Briones, P Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2011)
Crystal structure of (1R,5S)-9-nitro- 1,2,3,4,5,6-hexahydro-1,5- methanopyrido[1,2-A][1,5]diazocin-8-One (9-Nitrocytisine), C11H 13O3N3 GaldÃ¡mez A.; GutiÃ©rrez-HernÃ¡ndez M.; Cassels, B.K.; SÃ¡ez-Briones P. Article SCOPUS Journal of the Chilean Chemical Society (2011)
HYDROGEN-BONDED SUPRAMOLECULAR ARRAY IN THE CRYSTAL STRUCTURE OF ETHYL 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLATE MONOHYDRATE Galdamez A., Garcia-Beltran; O, Cassels Article Journal of the Chilean Chemical Society (2011)
The development of a fluorescence turn-on sensor for cysteine, glutathione and other biothiols. A kinetic study Garcia-Beltran, O; Mena, N; Perez, EG; Cassels, BK; nunez mt, Werlinger; F, Zavala D.; Aliaga, ME; Pavez, P. Article Tetrahedron Letters (2011)
Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives Rodriguez-Diaz, M; Delporte C.; Cartagena, C; Cassels, BK; Gonzalez P.; Silva, X.; León F.; Wessjohann, LA Article ISI SCOPUS Journal of Pharmacy and Pharmacology (2011)
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors Luhr, S; Vilches-Herrera, M; Fierro, A.; Ramsay, RR; Edmondson, DE; Reyes-Parada, M; Cassels, BK; Iturriaga-Vasquez, P Article ISI SCOPUS Bioorganic and Medicinal Chemistry (2010)
Antifungal activity of saponin-rich extracts of Phytolacca dioica and of the sapogenins obtained through hydrolysis Di Liberto M.; Svetaz L.; FurlÃ¡n R.L.E.; Zacchino S.A.; Delporte C.; Novoa M.A.; Asencio M.; Cassels, B.K. Article SCOPUS Natural Product Communications (2010)
Behavioral Profiles in Rats Distinguish Among "Ecstasy," Methamphetamine and 2,5-Dimethoxy-4-Iodoamphetamine: Mixed Effects for "Ecstasy" Analogues Quinteros-Munoz, D; Saez-Briones, P; Diaz-Veliz, G; Mora-Gutierrez, S; Rebolledo-Fuentes, M; Cassels, BK Article ISI SCOPUS Behavioral Neuroscience (2010)
In silico characterization of cytisinoids docked into an acetylcholine binding protein Abin-Carriquiry, JA; Zunini, MP; Cassels, BK; Wonnacott, S; Dajas, F Article ISI SCOPUS Bioorganic and Medicinal Chemistry Letters (2010)
Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats Abin-Carriquiry, JA; Urbanavicius, J; Scorza, C; Rebolledo-Fuentes, M; Wonnacott, S; Cassels, BK; Dajas, F Article European Journal of Pharmacology (2010)
Molecular determinants for competitive inhibition of ?4?2 nicotinic acetylcholine receptors Iturriaga-Vasquez, P; Garcia-Beltran, O; Cassels, B.K.; Zapata-Torres, G; Carbone, A.; Bermudez I.; Livingstone P.D.; Wonnacott, S; Biggin, P. C. Article Molecular Pharmacology (2010)
Molecular Determinants for Competitive Inhibition of alpha 4 beta 2 Nicotinic Acetylcholine Receptors Iturriaga-Vasquez, P; Carbone, A; Garcia-Beltran, O; Livingstone, PD; Biggin, PC; Cassels, BK; Wonnacott, S; Zapata-Torres, G; Bermudez, I Article Molecular Pharmacology (2010)
Synthesis of Lakshminine and Antiproliferative Testing of Related Oxoisoaporphines Castro-Castillo, V; Rebolledo-Fuentes, M; Theoduloz, C; Cassels, BK Article ISI SCOPUS Journal of Natural Products (2010)
In vivo effects of 3-iodocytisine=> Pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites Zambrano, CA; Marks, MJ; Cassels, BK Article Neuropharmacology (2009)
Molecular modeling of the ?9?10 nicotinic acetylcholine receptor subtype Pérez E.G.; Cassels, B.K.; Zapata-Torres, G Article BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2009)
Molecular modeling of the alpha 9 alpha 10 nicotinic acetylcholine receptor subtype Perez, EG; Cassels, BK; Zapata-Torres, G Article Bioorganic & Medicinal Chemistry Letters (2009)
Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors Vilches-Herrera, M; Miranda-Sepulveda, J; Rebolledo-Fuentes, M; Fierro A., Luhr; S, Iturriaga-Vasquez; P, Cassels; BK, Reyes-Parada Article Bioorganic & Medicinal Chemistry (2009)
SYNTHESIS OF A-RING-SUBSTITUTED 5,6,8,12B-TETRAHYDROISOINDOLO[1,2-A]ISOQUINOLIN-8-ONES Castro-Castillo, V; Rebolledo-Fuentes, M; Cassels, BK Article Journal of the Chilean Chemical Society (2009)
In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives=> Implications for Parkinson's Disease Abin-Carriquiry, JA; Costa G, Urbanavicius; J, Cassels; BK, Rebolledo-Fuentes; M, Wonnacott; S, Dajas Article EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
Quantum-chemical, NMR and X-ray diffraction studies on (+/-)-1-[3,4-(methylenedioxy)phenyl]-2-methylaminopropane Zapata-Torres, G; Cassels, BK; Parra-Mouchet, J; Mascarenhas, YP; Ellena, J; De Araujo, AS Article JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2008)
Quantum-chemical, NMR and X-ray diffraction studies on (±)-1-[3,4-(methylenedioxy)phenyl]-2-methylaminopropane Zapata-Torres, G; Cassels, B.K.; Parra-Mouchet, J; Mascarenhas Y.P.; Ellena, J.; De Araujo A.S. Article JOURNAL OF MOLECULAR GRAPHICS AND MODELLING (2008)
Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers Iturriaga-Vasquez, P; Perez, EG; Slater, EY; Bermudez, I; Cassels, BK Article Bioorganic & Medicinal Chemistry (2007)
Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)(2A) and 5-HT2C receptors Moya PR, Berg; KA, Gutierrez-Hernandez; MA, Saez-Briones; P, Reyes-Parada; M, Cassels; BK, Clarke Article JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives=> Insights from molecular modeling studies Fierro A., Osorio-Olivares; M, Cassels; BK, Edmondson; DE, Sepulveda-Boza; S, Reyes-Parada Article Bioorganic & Medicinal Chemistry (2007)
?4?2 nicotinic receptors with high and low acetylcholine sensitivity: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine Moroni M.; Bermudez I.; Zwart, R; Sher, E; Cassels, B.K. Article Molecular Pharmacology (2006)
alpha 4 beta 2 nicotinic receptors with high and low acetylcholine sensitivity=> Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine Moroni, M; Zwart, R; Sher, E; Cassels, BK; Bermudez, I Article Molecular Pharmacology (2006)
C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists Abin-Carriquiry, JA; Voutilainen, MH; Barik, J; Cassels, BK; Iturriaga-Vasquez, P; Bermudez, I; Durand, C; Dajas, F; Wonnacott, S Article EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Characterization of mitochondrial iron uptake in HepG2 cells Mazariegos, DI; Cabantchik, ZI; Cassels, BK Article Biological Research (2006)
Effects of 9,10-dihydroxy-4,4-dimethyl-5,8-dihydro-1(4H)-anthracenone derivatives on tumor cell respiration Araya-Maturana, R; Cardona, W; Cassels, BK; Delgado-Castro, T; Ferreira, J; Miranda, D.; Pavani, M; Pessoa-Mahana H., Soto-Delgado; J, Weiss-Lopez Article Bioorganic & Medicinal Chemistry (2006)
Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture=> Effects of cytisine and its bromo derivatives Varas, R; Valdes, V; Iturriaga-Vasquez, P; Cassels, BK; Iturriaga R, Alcayaga Article Brain Research (2006)
N-substitution and ?1-adrenergic receptor affinity of laudanosine analogues Iturriaga-Vasquez, P; Cassels, B.K.; Ivorra M.D.; Dxocom M.P. Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2006)
Neurochemical and behavioural characterisation of alkoxyamphetamine derivatives in rats Romero, CA; Bustamante, DA; Zapata-Torres, G; Goiny, M; Cassels B; Herrera-Marschitz, M Article ISI SCOPUS NEUROTOXICITY RESEARCH (2006)
SYNTHESIS OF 2-ARYL-1,3-PROPANEDIAMINES USING A ONE-POT KNOEVENAGEL-MICHAEL SEQUENCE Iturriaga-Vasquez, P; Luhr-Sierra, S; Rezende, MC; Cassels, BK Article Journal of the Chilean Chemical Society (2006)
Topical anti-inflammatory activity of 2 alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae Aguirre, MC; Delporte C, Backhouse; N, Erazo; S, Letelier; ME, Cassels; BK, Silva; X, Alegria; S, Negrete Article Bioorganic & Medicinal Chemistry (2006)
Topical anti-inflammatory activity of 2?-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae Aguirre-M, C; Delporte C.; Backhouse, N; ERAZO, S; Negrete, R; Letelier M.E.; Cassels, B.K.; Silva, X.; Alegria, S Article BIOORGANIC AND MEDICINAL CHEMISTRY (2006)
8-NH2-boldine, an antagonist of alpha(1A) and alpha(1B) adrenoceptors without affinity for the alpha(1D) subtype: Structural requirements for aporphines at alpha(1)-adrenoceptor subtypes Ivorra, MD; Valiente M.; Martínez, S.; Madrero, Y; Noguera, MA; Cassels, BK; Sobarzo, EM; D'Ocon, P Article ISI SCOPUS PLANTA MEDICA (2005)
A CONVENIENT, RENEWABLE SOURCE OF THE ANXIOLYTIC PROAPORPHINE ALKALOID GLAZIOVINE=> DUGUETIA VALLICOLA LEAVES Perez, EG; Saez, J; Cassels, BK Article Journal of the Chilean Chemical Society (2005)
Crystal structure of isotetrandrine, C38H42N 2O6 Galdamez, A.; Cassels, B.K.; Manriquez, V.; Iturriaga-Vasquez, P Article ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2005)
Crystal structure of isotetrandrine,C38H42N2O6 Galdamez A., Iturriaga-Vasquez; P, Cassels; BK, Manriquez V. Article Zeitschrift f?r Kristallographie - New Crystal Structures (2005)
Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors Exley, R; Iturriaga-Vasquez, P; Lukas, RJ; Sher, E; Cassels, BK; Bermudez I. Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2005)
Structure-affinity relationships of halogenated predicentrine and glaucine derivatives at D-1 and D-2 dopaminergic receptors=> halogenation and D-1 receptor selectivity Asencio, M; Hurtado-Guzman, C; Lopez, JJ; Cassels, BK; Protais, P; Chagraoui, A Article Bioorganic & Medicinal Chemistry (2005)
Structure-affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: Halogenation and D1 receptor selectivity Asencio M.; Hurtado-Guzman, C; López J.J.; Cassels, B.K.; Protais, P; Chagraoui, A Article BIOORGANIC AND MEDICINAL CHEMISTRY (2005)
Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: Biological activities, CoMFA analysis, and active site modeling Gallardo-Godoy, A; Fierro, A.; McLean, TH; Castillo M.; Cassels, BK; Reyes-Parada, M; Nichols, DE Article ISI SCOPUS JOURNAL OF MEDICINAL CHEMISTRY (2005)
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT 2A receptor antagonists in Xenopus laevis oocytes Villalobos C. A.; Huidobro-Toro J.P.; Bull, P; Saez P.; Cassels, B.K. Article BRITISH JOURNAL OF PHARMACOLOGY (2004)
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes Villalobos, CA; Bull, P.; Saez P, Cassels; BK, Huidobro-Toro Article BRITISH JOURNAL OF PHARMACOLOGY (2004)
Analgesic and behavioral effects of amphetamine enantiomers, p-methoxyamphetamine and n-alkyl-p-methoxyamphetamine derivatives Bustamante D, Diaz-Veliz; G, Paeile; C, Zapata-Torres; G, Cassels Article PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2004)
Effects of natural flavones and flavonols on the kinase activity of Cdk5 Zapata-Torres, G; Opazo, F; Salgado C., Munoz; JP, Krautwurst; H, Mascayano C.; Sepulveda-Boza, S; Maccioni RB, Cassels Article Journal of Natural Products (2004)
GEOMETRICAL ISOMERISM IN ?-NITROSTYRENES: PREFERRED CONFORMATIONS OF (E)- AND (Z)- 1-(4-METHYLTHIOPHENYL)-2-NITROBUTENES HURTADO-GUZMÁN, CLAUDIO; Iturriaga-Vásquez, Patricio; Zapata-Torres, Gerald; Cassels, Bruce K. Article SCIELO JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2004)
MAO inhibition by arylisopropylamines=> the effect of oxygen substituents at the beta-position Osorio-Olivares, M; Rezende, MC; Sepulveda-Boza, S; Cassels, BK Article Bioorganic & Medicinal Chemistry (2004)
Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha(1)-adrenoceptor subtypes Valiente, M; D'Ocon, P; Noguera, MA; Cassels, BK; Lugnier, C; Ivorra, MD Article Planta Medica (2004)
A two-step method for the preparation of homochiral cathinones Osorio-Olivares, M; Rezende, MC; Sepulveda-Boza, S; Cassels, BK; Baggio, RF; Munoz-Acevedo, JC Article TETRAHEDRON-ASYMMETRY (2003)
An expedient synthesis of unusual oxoisoaporphine and annelated quinoline derivatives Sobarzo-Sanchez, E; Cassels, BK; Castedo, L Article SYNLETT (2003)
Complete H-1 and C-13 NMR spectral assignment of hydrogenated oxoisoaporphine derivatives Sobarzo-Sanchez, E; Cassels, BK; Castedo, L Article Magnetic Resonance in Chemistry (2003)
Complete structural and spectral assignment of oxoisoaporphines by HMQC and HMBC experiments Sobarzo-Sanchez, E; Cassels, BK; Jullian C, Castedo Article Magnetic Resonance in Chemistry (2003)
Crystal structure of 2-[(3,4-dimethoxy)-phenethyl-3-(3,4-dimethoxy)- phenethylamino]-2,3-dihydro-isoindol-1-one, C28H32N 2O5 Sobarzo-Sanchez, E; Cassels, B.K.; Castedo, L.; Valencia-Matarranz, L Article SCOPUS ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2003)
Crystal structure of 3-[(3-oxo-1,3-dihydro-isobenzofuran-1-yl)- phenethylamino]-2-phenethyl-2,3-dihydro-isoindol-l-one, C28H 28N2O3 Sobarzo-Sanchez, E; Cassels, B.K.; Castedo, L.; Valencia-Matarranz, L Article SCOPUS ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2003)
Crystal structure of 5-methoxy-2,3-dihydro-7H-dibenzo[de,h]quinolin-7-one, C17H13O2 Sobarzo-Sanchez, E; Cassels, B.K.; Castedo, L.; Valencia-Matarranz, L Article SCOPUS ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2003)
Effects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice Loghin, F; Chagraoui, A; Asencio, M; Comoy, E; Speisky H, Cassels; BK, Protais Article European Journal of Pharmaceutical Sciences (2003)
Emerging therapeutic approaches for Alzheimer's disease Enfoques terapéuticos emergentes para la enfermedad de Alzheimer Cassels, B.K. Article SCOPUS Revista Chilena de Neuro-Psiquiatria (2003)
Enfoques terapéuticos emergentes para la enfermedad de Alzheimer. 25. Cassels, B.K. Article Rev. Chil. Neuro-Psiquiatría (2003)
Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes Slater, YE; Houlihan, LM; Maskell, PD; Exley, R; Bermudez, I; Lukas, RJ; Valdivia, AC; Cassels, BK Article Neuropharmacology (2003)
Monoamine oxidase inhibitory properties of optical isomers and N-substituted derivatives of 4-methylthioamphetamine Hurtado-Guzman, C; Fierro A., Iturriaga-Vasquez; P, Sepulveda-Boza; S, Cassels; BK, Reyes-Parada Article JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2003)
Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action Iturriaga-Vasquez, P; Miquel R., Ivorra; MD, D'Ocon; MP, Cassels Article Journal of Natural Products (2003)
Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT 2A and 5-HT 2C receptors Acuna-Castillo, C; Villalobos C.; Moya, P.R.; Saez P.; Cassels, B.K.; Huidobro-Toro J.P. Article BRITISH JOURNAL OF PHARMACOLOGY (2002)
Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptors Acuna-Castillo, C; Villalobos, C.; Moya PR, Saez P; Cassels, BK; Huidobro-Toro, J Article BRITISH JOURNAL OF PHARMACOLOGY (2002)
Effects of 4,4-dimethyl-5,8-dihydroxynaphtalene-1-one and 4,4-dimethyl-5,8-dihydroxytetralone derivatives on tumor cell respiration Araya-Maturana, R; Delgado-Castro, T; Garate, M; Ferreira, J; Pavani, M; Pessoa-Mahana H., Cassels Article Bioorganic & Medicinal Chemistry (2002)
Effects of the plant alkaloid tetrandrine on human nicotinic acetylcholine receptors Slater, Y; Houlihan, LM; Cassels, BK; Lukas, RJ; Bermudez, I Article EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
New heterocyclic skeletons derived from the aporphine alkaloid boldine Sobarzo-Sanchez, E; Jullian C, Cassels; BK, Saitz C Article SYNTHETIC COMMUNICATIONS (2002)
S-oxidation products of alkylthioamphetamines Rezende, MC; Núñez, C; Sepulveda-Boza, S; Cassels, BK; Hurtado-Guzman, C Article SYNTHETIC COMMUNICATIONS (2002)
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities Backhouse, CN; Delporte, CL; Negrete, RE; Erazo, S; Zuniga, A; Pinto A., Cassels Article Journal of Ethnopharmacology (2001)
Activity of cytisine and its brominated isosteres on recombinant human alpha 7, alpha 4 beta 2 and alpha 4 beta 4 nicotinic acetylcholine receptors Houlihan, LM; Slater, Y; Guerra, DL; Peng, JH; Kuo, YP; Lukas, RJ; Cassels, BK; Bermudez, I Article Journal of Neurochemistry (2001)
Computational study on the conformations of dopamine, its ?- and ortho-methylated derivatives and their N-protonated forms Aliste M.P.; Cassels, B.K. Article SCOPUS JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (2001)
Computational study on the conformations of dopamine, its alpha- and ortho-methylated derivatives and their N-protonated forms Aliste, MP; Cassels, BK Article JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (2001)
Differential incorporation of L- and D-N-acyl-1-phenyl-d(5)-2-aminopropane in a cesium N-dodecanoyl-L-alaninate cholesteric nematic lyomesophase Weiss-Lopez, BE; Azocar M., Montecinos; R, Cassels; BK, Araya-Maturana Article Langmuir (2001)
Electron spin resonance studies and theoretical quantum calculations of free radicals generated from anthracenetrione by electrochemical and microsomal reduction Olea-Azar, C; Mendizabal F., Alarcon J; Briones R., Cassels; BK, Delgado-Castro; T, Araya-Maturana Article Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2001)
Heterogeneous catalysts in the preparation of 2-aryl-1,3-dinitropropanes from ?-nitrostyrenes or benzaldehydes Fierro, A.; Rezende M.C.; Sepulveda-Boza, S; Reyes-Parada, M; Cassels, B.K. Article SCOPUS JOURNAL OF CHEMICAL RESEARCH-S (2001)
Heterogeneous catalysts in the preparation of 2-aryl-1,3-dinitropropanes from beta-nitrostyrenes or benzaldehydes Fierro A., Rezende; MC, Sepulveda-Boza; S, Reyes-Parada; M, Cassels Article JOURNAL OF CHEMICAL RESEARCH-S (2001)
Oxazine- and oxazole-fused derivatives of the alkaloid boldine and their complete structural and spectral assignments by HMQC and HMBC experiments Sobarzo-Sanchez, E; Cassels, BK; Saitz-Barria, C Article Magnetic Resonance in Chemistry (2001)
ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT(2a) and 5-HT(2c) receptor agonist Acua-Castillo C.; Huidobro-Toro J.Pablo; Scorza, C; Reyes-Parada, M; Cassels, B.K. Article SCOPUS LIFE SCIENCES (2000)
ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT2a and 5-HT2c receptor agonist Acuna-Castillo, C; Scorza, C; Reyes-Parada, M; Cassels, BK; Huidobro-Toro, JP Article Life Sciences (2000)
Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones Dagnino-Subiabre, A; Cassels, BK; Baez S., Johansson; AS, Mannervik; B, Segura-Aguilar Article Biochemical and Biophysical Research Communications (2000)
Halogenated boldine derivatives with enhanced monoamine receptor selectivity Sobarzo-Sanchez, EM; Arbaoui, J; Protais, P; Cassels, BK Article Journal of Natural Products (2000)
Phylogenetic and biogeographic aspects of Sophora sect. Edwardsia (Papilionaceae) Pena R.C.; Iturriaga, L; Montenegro,G.; Cassels, B.K. Article SCOPUS PACIFIC SCIENCE (2000)
Preparation of dopaminergic N-alkyl-benzyltetrahydroisoquinolines using a 'one-pot' procedure in acid medium Andreu, I; Cortés D., Protais; P, Cassels; BK, Chagraoui; A, Cabedo Article Bioorganic & Medicinal Chemistry (2000)
A novel route to 5,7-dimethoxy-6-hydroxyflavone Osorio-Olivares, M; Rezende M.C.; Cassels, B.K.; Sepulveda-Boza, S Article SYNTHETIC COMMUNICATIONS (1999)
Complete assignment of the 13C NMR spectra of a series of 5,8-disubstituted 4,4-dimethylanthracene-1,9,10(4h)-triones Araya-Maturana, R; Delgado-Castro, T; Jullian C.; Cassels, B.K.; Hurtado-Guzman, C Article MAGNETIC RESONANCE IN CHEMISTRY (1999)
CRYSTAL STRUCTURES OF (E)-1-(3,4,5-TRIMETHOXYPHENYL)-2-NITROETHENE AND (E)-1-(3,4,5-TRIMETHOXYPHENYL)-2-NITROPROPENE Conceicao Silva A.J.G.; Giotto M.T.S.; Mascarenhas Y.P.; Sepulveda-Boza, S; Cassels, B.K. Article SCIELO BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA (1999)
Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission Dajas-Bailador F.A.; bonilla, c; Dajas, F; Asencio M.; Cassels, B.K.; Scorza, M.C.; Echeverry, C; Reyes-Parada, M; Silveira, R.; Protais, P; Russell G. Article General Pharmacology: The Vascular System (1999)
Effects of some ?-carboline alkaloids on intact Trypanosoma cruzi epimastigotes Rivas, P; Cassels, B.K.; Morello A.; Repetto Y Article Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology (1999)
Total synthesis of annofolin Vallejos G.; Rezende M.C.; Sepùlveda S.; Cassels, B.K. Article SYNTHETIC COMMUNICATIONS (1999)
13C-NMR and theoretical studies of internal rotation in methylated anilines Zapata-Torres, G; Parra-Mouchet, J; Cassels, B.K. Article BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA (1998)
? 1-Adrenergic and 5-HT 2-serotonergic effects of some ?-alkoxy-?-phenylethylamines on isolated rat thoracic aorta Torres M.A.; Rezende C.; Cassels, B.K. Article General Pharmacology: The Vascular System (1998)
Antipyretic, hypothermic and antiinflammatory activities and metabolites from Solanum ligustrinum Lood. Delporte C.; Backhouse, N; Negrete, R; Salinas P.; Rivas, P; Cassels, B.K.; San Feliciano A. Article PHYTOTHERAPY RESEARCH (1998)
Cardiovascular effects of plant secondary metabolites norarmepavine, coclaurine and norcoclaurine Morales, M.A.; Bustamante S.E.; Brito G.; Paz, D; Cassels, B.K. Article PHYTOTHERAPY RESEARCH (1998)
Crystal structure of 7-bromo-5,8-dihydroxy-4,4-dimethyl-4H-naphthalen-1-one Mejias, L; Rezende M.C.; Sepulveda-Boza, S; Araya-Maturana, R; Boys, D; Cassels, B.K.; Manriquez, V. Article BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA (1998)
Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine Cabedo, N; Cortés D.; Protais, P; Cassels, B.K. Article JOURNAL OF NATURAL PRODUCTS (1998)
The regioselective bromination of 4,4-dimethyl-5,8-dihydroxy-4H- naphthalen-1-one Mejias, L; Rezende M.C.; Sepùlveda S.; Araya, R; Cassels, B.K. Article SYNTHETIC COMMUNICATIONS (1998)
Antiinflammatory and antipyretic metabolites of Acaena splendens Backhouse, N; Delporte C.; Negrete, R; Suarez, S.; Cassels, B.K.; Breitmaier E.; Schneider, C Article International Journal of Pharmacognosy (1997)
Antiinflammatory and antipyretic metabolites of Acaena splendens. 24. Backhouse, N.; Delporte, C.; Negrete, R.; Suárez, S.; Cassels, B.K.; Breitmaier, E.; Schneider, C. Article Int. J. Pharmacogn. (1997)
Lysozyme inactivation by free radicals can occur independently of reactive carbonyl formation Cassels, B.K. Article FASEB JOURNAL (1997)
Monoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives. Structure-activity relationships Scorza, M.C.; Carrau C.; Silveira, R.; Reyes-Parada, M; Zapata-Torres, G; Cassels, B.K. Article BIOCHEMICAL PHARMACOLOGY (1997)
Protective effect of boldine in experimental colitis Cotteland M.; Brunser O.; Guzman, L; Romero, S.; Cassels, B.K.; Jimenez, I.; Speisky H. Article PLANTA MEDICA (1997)
(S)-1,10-dimethoxy-2,9-dihydroxy-aporphinium chloride (boldine hydrochloride), C 19H 22NO 4 +.Cl - Asencio M.; Cassels, B.K.; Manriquez, V.; Boys, D Article ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY (1996)
(±)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors Reyes-Parada, M; Scorza, C; Romero, V; Silveira, R.; Medina, J.H.; Andrus D.; Nichols D.E.; Cassels, B.K. Article NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (1996)
6-bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids Marder M.; Wasowski, C; Paladini A.C.; Viola, H.; Wolfman C.; Medina, J.H.; Waterman P.G.; Cassels, B.K. Article BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1996)
Anti-inflammatory and antipyretic activities of Cuscuta chilensis, Cestrum parqui and Psoralea glandulosa. 23. Backhouse, N.; Delporte, C.; Negrete, R.; Salinas, P.; Pinto, A.; Aravena, S.; Cassels, B.K. Article Int. J. Pharmacogn. (1996)
Antiinflammatory and antipyretic activities of Cuscuta chilensis, Cestrum parqui and Psoralea glandulosa Backhouse, N; Delporte C.; Negrete, R; Salinas P.; Pinto, A; Aravena S.; Cassels, B.K. Article International Journal of Pharmacognosy (1996)
Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes Bannach, R; Valenzuela A.; Speisky H.; Cassels, B.K.; Nuñez-Vergara, L. J. Article Cell Biology and Toxicology (1996)
Phylogenetic relationships among Chilean Sophora species Pena R.C.; Cassels, B.K. Article BIOCHEMICAL SYSTEMATICS AND ECOLOGY (1996)
Cyclobakuchiols A and B from Psoralea glandulosa. Backhouse, C.N.; Delporte, C.L.; Negrete, R.E.; Cassels, B.K.; Schneider, C.; Breitmaier, E.; San Feliciano, A. Article PHYTOCHEMISTRY (1995)
Efecto de un extracto seco de boldo sobre el tránsito intestinal oro-cecal en voluntarios sanos. Gotteland, M.; Espinoza, J.; Cassels, B.K.; Speisky, H. Article Rev Med Chile (1995)
Structure-antioxidative activity relationships in benzylisoquinoline alkaloids. Cassels, B.K.; Asencio, M.; Conget, P.; Speisky, H.; Videla, L.A.; Lissi, E.A. Article Pharmacol. Res. (1995)
The preparation of potentially psychoactive -alkoxyphenethylamines. Torres, M.A.; Cassels, B.K.; Rezende, M.C. Article Synth. Commun. (1995)
Anti-inflammatory and antipyretic effects of boldine. Backhouse, N.; Delporte, C.; Guivernau, M.; Cassels, B.K.; Speisky, H. Article Agents Actions (1994)
Boldo and boldine: an emerging case of natural drug development. Speisky, H.; Cassels, B.K. Article Pharmacol. Res. (1994)
Constituents of Centaurea chilensis. Sepúlveda, S.; Delhvi, S.; Koch, B.; Zilliken, F.; Cassels, B.K. Article FITOTERAPIA (1994)
Constituents of Senecio hollermayerii. Sepúlveda, S.; Delhvi, S.; Zilliken, F.; Cassels, B.K. Article FITOTERAPIA (1994)
Dimethylaminophenethylamine, a sensitive, highly selective, electrochemically detectable monoamine oxidase-B substrate. Reyes-Parada, M.; Scorza, M.C.; Silveira, R.; Dajas, F.; Cassels, B.K. Article Life Sci. (1994)
Infrared spectra of nitrostyrene derivatives Weiss, B.; Araya, R.; Clavijo, R.; Cassels, B.K. Article Spectrochim. Acta A (1994)
Monoamine oxidase inhibitory effects of some 4-aminophenethylamine derivatives. Reyes-Parada, M.; Scorza, M.C.; Silveira, R.; Dajas, F.; Costa, G.; Tipton, K.F.; Cassels, B.K. Article Biochem. Pharmacol. (1994)
Nitro radical anion formation from nitro-substituted amphetamine derivatives. Núñez-Vergara, L.J.; Matus, C.; Alvarez, A.; Cassels, B.K.; Squella, J.A. Article ELECTROANALYSIS (1994)
Some fluoro and nitro analogues of hallucinogenic amphetamines. Jara, A.N.; Torres, M.A.; Cassels, B.K.; Rezende, M.C. Article Synth. Commun. (1994)
Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi. Morello, A.; Lipchenca, I.; Cassels, B.K.; Speisky, H.; Aldunate, J.; Repetto, Y. Article Comp. Biochem. Physiol. (1994)
-Adrenergic and 5-HT2-serotonergic effects of some -phenylethylamines on isolated rat thoracic aorta. Sáez, P.; Borges, Y.; González, E.; Cassels, B.K. Article Gen. Pharmacol. (1994)
(R)- and (S)-coclaurine from the bark of Peumus boldus. Asencio, M.; Cassels, B.K.; Speisky, H.; Valenzuela, A. Article FITOTERAPIA (1993)
Determination of boldine in plasma by HPLC. 62) Speisky, H.; Cassels, B.K.; Sanhueza, V.; Nieto, S.; Valenzuela, A.; Núñez-Vergara, L.J. Article J. Chromatog.-Biomed. Appl. (1993)
Electrochemical oxidation of methylenedioxyamphetamines. Squella, J.A.; Cassels, B.K.; Arata, M.; Bavestrello, M.P.; Núñez-Vergara, L.J. Article TALANTA (1993)
Flavonoids from the twigs of Eucryphia glutinosa. Sepúlveda-Boza, S.; Delhvi, S.; Cassels, B.K. Article PHYTOCHEMISTRY (1993)
Preliminary voltammetric data for the oxidation of 4-methylaminophenethylamine derivatives in buffer and in aprotic solvents. Rojas, E.; Olea-Azar, C.; Norambuena, E.; Reyes-Parada, M.; Cassels, B.K. Article Bol. Soc. Chil. Quim (1993)
Structure of (E)-1-(4-methoxyphenyl)-2-nitropropene. Boys, D.; Manríquez, V.; Cassels, B.K. Article Acta Cryst. (1993)
The methylation of boldine with diazomethane. Asencio, M.; Cassels, B.K.; Speisky, H. Article Bol. Soc. Chil. Quim (1993)
Two new antiinflammatory elemanolides from Centaurea chilensis. Negrete, R.; Backhouse, N.; Cajigal, I.; Delporte, C.; Cassels, B.K.; Breitmaier, E.; Eckhardt, G. Article J. Ethnopharmacol. (1993)
Cathodic behavior of 4,5-dimethoxy-2-nitroamphetamine. Squella, J.A.; Pezzani, M.; Cassels, B.K.; Aillón-Torres, M.; Rezende, M.C.; Núñez-Vergara, L.J. Article ELECTROANALYSIS (1992)
Electrochemical study of some 2,5-dimethoxyamphetamine derivatives. , J.A.; Berguecio, H.A.; Hernández, A.; Cassels, B.K.; Núñez-Vergara, L.J. Article J. Chim. Phys. (1992)
One- and two-dimensional NMR in the structure determination of 3-acetoxy-17,21-epoxyhopane from Centaurea chilensis. 22. Hartmann, R.; Breitmaier, E.; Camargo, R.C.; Negrete, R.E.; Backhouse, N.; Delporte, C.; Cassels, B.K. Article Plantes Méd. Phytothér,J. prakt. Chem. (1992)
Regioselective ring-opening by propanethiolate of 1,3-benzodioxoles with electron-withdrawing substituents. Cassels, B.K.; Radetski, C.; Rezende, M.C. Article Rec. Trav. Chim. Pays-Bas (1992)
The action of the psychoactive drug 2C-B on isolated rat thoracic aorta. Lobos, M.; Borges, Y.; González, E.; Cassels, B.K. Article Gen. Pharmacol. (1992)
Antioxidant properties of the alkaloid boldine in systems undergoing lipid peroxidation and enzyme inactivation. Speisky, H.; Cassels, B.K.; Lissi, E.A.; Videla, L.A. Article Biochem. Pharmacol. (1991)
Estructura cristalina del (E)-1-(4-dimetilaminofenil)-2-nitropropeno. Brito, I.; Manríquez, V.; Reyes-Parada, M.I.; Cassels, B.K. Article Bol. Soc. Chil. Quim (1991)
Inhibitory effect of boldine on fish oil oxidation. 57) Valenzuela, A.; Nieto, S.; Cassels, B.K.; Speisky, H. Article J. Am. Oil Chem. Soc. (1991)
Acerca de la bromación del 2,5-dimetoxibenzaldehido - Una síntesis corta de 4-alquiltio-2,5-dimetoxibenzaldehidos. Cassels, B.K.; Sepúlveda-Boza, S. Article Bol. Soc. Chil. Quim (1990)
An aryltetralin lignan from Persea lingue. Sepúlveda-Boza, S.; Delhvi, S.; Cassels, B.K. Article PHYTOCHEMISTRY (1990)
Dibenzyl trisulfide and trans-N-methyl-4-methoxyproline from Petiveria alliacea. de Sousa, J.R.; Demuner, A.J.; Pinheiro, J.A.,;Breitmaier, E.; Cassels, B.K. Article PHYTOCHEMISTRY (1990)
Carbon-13 nmr spectra of azafluorenones. Cassels, B.K.; Tadi?, D.; Laprévote, O.; Cavé, A. Article J. Nat. Prod. (1989)
Steroids, a lignan and a flavonoid from Centaurea melitensis. 21. Negrete, R.E.; Backhouse, N.; Prieto, P.; Mejías, H.; Camargo, R.C.; Cassels, B.K.; Breitmaier, E.; Hartmann, R. Article Plantes Méd. Phytothér, (1989)
Bisbenzylisoquinoline biosynthesis in Berberis stolonifera cell cultures. Stadler, R.; Loeffler, S.; Cassels, B.K.; Zenk, M.H. Article PHYTOCHEMISTRY (1988)
Guaianolides from Centaurea chilensis and Centaurea floccosa. 19. Negrete, R.E.; Backhouse, N.; San Martín, A.; Cassels, B.K.; Hartmann, R.; Breitmaier, E. Article Chemiker-Zeitung (1988)
Spectral properties of ring-C-oxygenated 4-azafluorenes and 4-azafluorenones. The structures of natural onychine derivatives. Tadi?, D.; Cassels, B.K.; Cavé, A. Article HETEROCYCLES (1988)
A quantum-chemical and experimental study on the hallucinogen (±)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON) Gómez-Jeria, J.S.; Cassels, B.K.; Saavedra-Aguilar, J.C. Article Eur. J. Med. Chem. (1987)
Alcaloïdes de Annona hayesii. Rasamizafy, S.; Hocquemiller, R.; Cassels, B.K.; Cavé, A. Article J. Nat. Prod. (1987)
Alkaloids of Alphonsea sclerocarpa. Tadi?, D.; Wannigama, G.P.; Cassels, B.K.; Cavé, A.; Lebœuf, M. Article J. Nat. Prod. (1987)
Azafluorenones from Oxandra cf.major and biogenetic considerations. Arango, G.J. ; Cortes, D. ; Cassels, B.K. ; Cavé, A. ; Mérienne, C. Article PHYTOCHEMISTRY (1987)
Bisbenzylisoquinoline alkaloids in Berberis cell cultures. Cassels, B.K.; Breitmaier, E.; Zenk, M.H. Article PHYTOCHEMISTRY (1987)
Fate of ingested aristolochic acids in Battus archidamas. Urzúa, A.; Rodríguez, R.; Cassels, B.K. Article Biochem. Syst. Ecol. (1987)
Kinabaline and the aporphinoid biogenesis of azaanthracene and azafluorene alkaloids. Tadi?, D.; Cassels, B.K.; Lebœuf, M.; Cavé, A. Article PHYTOCHEMISTRY (1987)
Revised structures of the alkaloids from Guatteria dielsiana. Tadi?, D.; Cassels, B.K.; Cavé, A.; Goulart, M.O.F.; De Oliveira, A.B. Article PHYTOCHEMISTRY (1987)
Revision of the early steps of reticuline biosynthesis. Stadler, R.; Kutchan, T.M.; Loeffler, S.; Nagakura, N.; Cassels, B.K.; Zenk, M.H. Article Tetrahedron Lett. (1987)
The 13C-NMR spectra of 1,2,10-trioxygenated aporphines. Cassels, B.K.; Cavé, A.; Lebœuf, M. Article J. Nat. Prod. (1987)
Artavenustine, a catecholic berbine from Artabotrys venustus. Cavé, A.; Cassels, B.K.; Hocquemiller, R.; Lebœuf, M.; Rasamizafy, S.; Roblot, F.; Davoust, D.; Deverre, J.R.; Chan, K.C.; Hadi, A.H.A. Article J. Nat. Prod. (1986)
Azahomoaporphines: a new heterocyclic skeleton from Annonaceae. Cassels, B.K.; Cavé, A.; Davoust, D.; Hocquemiller, R.; Rasamizafy, S.; Tadi?, D. Article J. Chem. Soc., Chem. Commun. (1986)
Electronic structure and serotonin receptor binding affinity of 7-substituted tryptamines. Gómez-Jeria, J.S.; Morales-Lagos, D.; Cassels, B.K.; Saavedra-Aguilar, J.C. Article Quant. Struct.-Act. Relat. (1986)
Spectroscopic characterization of a new hallucinogen: 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON). 18. Gómez-Jeria, J.S.; Cassels, B.K.; Clavijo, R.; Vargas, V.; Quintana, R.; Saavedra-Aguilar, J.C. Article Microgram (1986)
A reevaluation of psychotomimetic amphetamine derivatives in humans. 17. Cassels, B.K.; Gómez-Jeria, J.S. Article J. Psychoactive Drugs (1985)
Analysis of a Maasai arrow poison. Cassels, B.K. Article J. Ethnopharmacol. (1985)
Bisbenzylisoquinoline alkaloids of Laurelia sempervirens. Cassels, B.K.; Urzúa, A. Article J. Nat. Prod. (1985)
Dímeros de proaporfina-1-benciltetrahidroisoquinolina en tallos de Berberis hakeoides. 16. Urzúa, A.; Torres, R.; Cassels, B.K.; Fajardo, V. Article Rev. Latinoam. Quím. (1985)
(+)-9-Hydroxymatrine from Sophora macrocarpa. Negrete, R.; Cassels, B.K.; Eckhardt, G. Article PHYTOCHEMISTRY (1983)
Aristolochic acids in Aristolochia chilensis and the Aristolochia-feeder Battus archidamas (Lepidoptera). Urzúa, A.; Salgado, G.; Cassels, B.K.; Eckhardt, G. Article Collect. Czech. Chem. Commun. (1983)
Mass spectrometry of aristolochic acids. Eckhardt, G.; Urzúa, A.; Cassels, B.K. Article J. Nat. Prod. (1983)
The rhoeadine alkaloids. Montgomery, C.T.; Cassels, B.K.; Shamma, M. Article J. Nat. Prod. (1983)
Additional alkaloids from Laurelia philippiana and L. novae-zelandiae. Urzúa, A.; Cassels, B.K. Article PHYTOCHEMISTRY (1982)
Aristolochic acids in Aristolochia chilensis. Urzúa, A.; Salgado, G.; Cassels, B.K.; Eckhardt, G. Article Planta Med. (1982)
Aurapten and flindersine from Zanthoxylum coco. 27) Muñoz, M.A.; Torres, R.; Cassels, B.K. Article J. Nat. Prod. (1982)
Chilenine: an isoindolobenzazepine alkaloid. Fajardo, V.; Elango, V.; Cassels, B.K.; Shamma, M. Article Tetrahedron Lett. (1982)
Leaf alkaloids of Sophora macrocarpa. Negrete, R.; Backhouse, N.; Cassels, B.K. Article J. Nat. Prod. (1982)
Síntesis de 1-aril-2-nitroalquenos antitumorales. 14. Cassels, B.K.; Herreros, S.; Ibáñez, C.; Rezende, M.C.; Sebastián, C.; Sepúlveda, S. Article Anales Asoc. Quím. Argentina (1982)
The use of nuclear magnetic resonance nuclear Overhauser enhancements in the structural elucidation of bisbenzylisoquinoline alkaloids. Guinaudeau, H.; Cassels, B.K.; Shamma, M. Article HETEROCYCLES (1982)
Calafatimine, a new imino bisbenzylisoquinoline alkaloid. Fajardo, V.; Garrido, M.; Cassels, B.K. Article HETEROCYCLES (1981)
(E)-1-(4'-hydroxy-3'-methoxyphenyl)-2-nitropropene, C10H11NO4 , V.; Watson, W.H.; Cassels, B.K.; Langs, D.A. Article Cryst. Struct. Commun. (1980)
A simple relationship between stereostructure and specific rotation for the bisbenzylisoquinolines. Cassels, B.K.; Shamma, M. Article HETEROCYCLES (1980)
The 13C-NMR spectra of cyclopeptide alkaloids. Hindenlang, D.M.; Shamma, M.; Miana, G.A.; Shah, A.H.; Cassels, B.K. Article Liebigs Ann. Chem. (1980)
Aislamiento de dos flavonoides y una nueva cromona de la corteza de Eucryphia cordifolia. 11. Sepúlveda, S.; Delhvi, S.; Cassels, B.K.; Tschesche, R.; Breitmaier, E. Article Contrib. Cient. Tecnol. (UTE) (1979)
Aislamiento de soforicósido de Schinus latifolius. 13. Sepúlveda, S.; Cassels, B.K. Article Rev. Latinoam. Quím. (1979)
Calafatine, an unusual bisbenzylisoquinoline alkaloid. Fajardo, V.; Urzúa, A.; Cassels, B.K. Article HETEROCYCLES (1979)
Coumarins and cinnamic acid from Gymnophyton isatidicarpum. 19) Torres, R.; Delle Monache, F.; Marini-Bettòlo, G.B.; Cassels, B.K. Article J. Nat. Prod. (1979)
Metabolitos secundarios de Berberis buxifolia. 12. Fajardo, V.; Urzúa, A.; Torres, R.; Cassels, B.K. Article Rev. Latinoam. Quím. (1979)
N,O-Diacetyl-4-hydroxynornantenine. Zabel, V.; Watson, W.H.; Urzúa, A.; Cassels, B.K. Article Acta Cryst. B (1979)
4-Hydroxynornantenine, a 4-hydroxylated noraporphine. Urzúa, A.; Cassels, B.K. Article Tetrahedron Lett. (1978)
Alkaloid chemosystematics, chemotaxonomy and biogenesis in the Atherospermataceae. Urzúa, A.; Cassels, B.K. Article Lloydia (1978)
Las conformaciones de la zizifina D en solución 10. Chang, C.-J.; Cassels, B.K. Article Contrib. Cient. Tecnol. (UTE) (1978)
Leaf alkaloids of Fagara mayu. Torres, R.; Cassels, B.K. Article PHYTOCHEMISTRY (1978)
Estudio preliminar de los alcaloides de Annona cherimolia. 8. Urzúa, A.; Cassels, B.K. Article Rev. Latinoam. Quím. (1977)
Weak bases of Laurelia novae-zelandiae. A cautionary note on oxoaporphine nmr assignments. Urzúa, A.; Cassels, B.K. Article HETEROCYCLES (1976)
(+)-Reticulina en Cryptocarya alba. Urzúa, A.; Torres, R.; Cassels, B.K. Article Rev. Latinoam. Quím. (1975)
Alcaloides de Laurelia sempervirens y Laurelia philippiana. 7. Urzúa, A.; Cassels, B.K.; Comin, J.; Sánchez, E. Article Anales Asoc. Quím. Argentina (1975)
Cumarinas de las hojas de Fagara mayu. 6. Torres, R.; Cassels, B.K. Article Anales Asoc. Quím. Argentina (1975)
Actividad biológica de Solanum malacoxylon Sendtner en ratas Rossi, F.M.; Cassels, B.K.; Daskal, H.; Dallorso, E.; Leiva, A. Article Medicina (Buenos Aires) (1974)
Aislamiento de diosgenina de Solanum tomatillo. 5. Morales, R.; Urzúa, A.; Cassels, B.K. Article Contrib. Cient. Tecnol. (UTE) (1974)
Alkaloids from Fagara mayu bark. Benages, I.A.; de Juárez, M.E.A.; Albonico, S.M.; Urzúa, A.; Cassels, B.K. Article PHYTOCHEMISTRY (1974)
Cyclopeptide alkaloids from Zizyphus oenoplia. Cassels, B.K.; Eckhardt, G.; Kaußmann, E.-U.; Tschesche, R. Article TETRAHEDRON (1974)
Zizyphine-F and G, new cyclopeptide alkaloids from Zizyphus oenoplia Mill. 11) Tschesche, R.; Khokhar, I.; Spilles, C.; Eckhardt, G.; Cassels, B.K. Article Tetrahedron Lett. (1974)
One-step synthesis of 1,1-dimethyl- and 1-spirocycloalkano-1,2,3,4-tetrahydro--carbolines. Carrasco, N.; Urzúa, A.; Cassels, B.K. Article J. Org. Chem. (1973)
Triterpene constituents of Kageneckia oblonga. Cassels, B.K.; Urzúa, A.; Cortés, M.; Garbarino, J.A. Article PHYTOCHEMISTRY (1973)
Isolation of candicine from Trichocereus chiloensis. Cortés, M.; Garbarino, J.A.; Cassels, B.K. Article PHYTOCHEMISTRY (1972)
Potential psychotomimetics. New bromoalkoxyamphetamines. Sepúlveda, S.; Valenzuela, R.; Cassels, B.K. Article J Med Chem (1972)
Principios activos de brebajes alucinógenos del Ucayali y del Amazonas peruano. 3. Urzúa, A.; Delgado, M.C.; Cassels, B.K. Article Rev. Latinoam. Quím. (1972)
Tribal and urban healing with hallucinogenic beverages in Amazonian Peru 3. Urzúa, A.; Delgado, M.C.; Cassels, B.K. Article Amer. J. Pharm. (1972)
Análisis de los aceites de semillas de Sophora macrocarpa y de Sophora tetraptera, sensu Reiche. 2. de Mayo, A.; Cassels, B.K. Article Contrib. Cient. Tecnol. (UTE) (1971)
Principios tóxicos de Solanum malacoxylon Sendtner. I. Acción de fracciones separadas por extracción con solventes selectivos sobre el metabolismo fosfo-cálcico y tejidos blandos del conejo 1. Cassels, B.K.; Rossi, F.M.; Dallorso, M.E.; Daskal, H.; Leiva, A. Article Contrib. Cient. Tecnol. (UTE) (1971)
On the resolution of pseudolaudanine and the configuration of its enantiomers. Cassels, B.K. Article Chem. & Ind. (London) (1966)
Resolution of O-benzoyl-(±)-codamine: L(+)- and D-(-)-codamines. Cassels, B.K.; Deulofeu, V. Article TETRAHEDRON (1966)
1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES: ¹H NMR CONFORMATIONAL STUDIES AND ROTATIONAL BARRIERS Iturriaga-Vásquez, Patricio; Zapata-Torres, Gerald; Caroli Rezende, Marcos; Cassels, Bruce K. Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
A CONVENIENT, RENEWABLE SOURCE OF THE ANXIOLYTIC PROAPORPHINE ALKALOID GLAZIOVINE: DUGUETIA VALLICOLA LEAVES PÉREZ, EDWIN G; SÁEZ, JAIRO; Cassels, Bruce K. Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
CATHODIC BEHAVIOR OF 2,3-DIHYDROOXOISOAPORPHINES COMPORTAMIENTO CATÓDICO DE 2,3-DIHIDRO-OXOISOAPORFINAS Sobarzo-Sánchez, Eduardo; Olea Azar, Claudio; Alarcon, Jaime; Opazo, Lucia; Cassels, Bruce K. Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
Characterization of mitochondrial iron uptake in HepG2 cells MAZARIEGOS, DORA INÉS; CABANTCHIK, Z. IOAV; Cassels, Bruce K.; NÚÑEZ, MARCO TULIO Article BIOLOGICAL RESEARCH
Enfoques terapéuticos emergentes para la enfermedad de Alzheimer Cassels, Bruce K. Article REVISTA CHILENA DE NEURO-PSIQUIATRIA
GEOMETRICAL ISOMERISM IN β-NITROSTYRENES: PREFERRED CONFORMATIONS OF (E)- AND (Z)- 1-(4-METHYLTHIOPHENYL)-2-NITROBUTENES HURTADO-GUZMÁN, CLAUDIO; Iturriaga-Vásquez, Patricio; Zapata-Torres, Gerald; Cassels, Bruce K. Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
N-SUBSTITUTION AND á1-ADRENERGIC RECEPTOR AFFINITY OF LAUDANOSINE ANALOGUES Iturriaga-Vásquez, Patricio; Cassels, Bruce K.; IVORRA, M. DOLORES; D'OCON, M. PILAR Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
SYNTHESIS OF 2-ARYL-1,3-PROPANEDIAMINES USING A ONE-POT KNOEVENAGEL-MICHAEL SEQUENCE Iturriaga-Vásquez, Patricio; LÜHR-SIERRA, SUSAN; Caroli Rezende, Marcos; Cassels, Bruce K. Article JOURNAL OF THE CHILEAN CHEMICAL SOCIETY


Cytisine and derivatives partially prevents the striatal dopamine decrease in an experimental model of Parkinson's disease Abin-Carriquiry, JA; Iturriaga-Vasquez, P; Costa G.; Urbanavicius, J; Ferreira M.; Cassels B; Wonnacott, S; Dajas, F Abstract ISI JOURNAL OF NEUROCHEMISTRY (2005)
Effects of halogenated derivatives of glaucine on the different isolated cyclic nucleotide phosphodiesterase isoenzymes Noguera, MA; D'Ocon, P; Ivorra, MD; Cassels B; Lugnier, C Abstract ISI FUNDAMENTAL CLINICAL PHARMACOLOGY (2001)


Betulinic Acid Suárez-Rozas, Cristian; Cassels, Bruce K. BookSection (2021)
Boldine Cassels, Bruce K.; Castro-Saavedra, Sebastián; Fuentes-Barros, Gonzalo BookSection (2021)
Peumus boldus Mol. Cassels, Bruce K.; Máthé, Akós; Bandoni, Arnaldo BookSection (2021)
Quillaja saponaria Mol. Delporte, Carla; Rodríguez-Díaz, Maite;Cassels, Bruce K. BookSection (2021)
Solanum crispum Ruiz & Pav. Cassels, Bruce K. BookSection (2021)
Alkaloids from the genus Duguetia Pérez, E.G.; Cassels, B.K. BookSection (2010)
Propiedades antioxidantes, citoprotectoras y relacionadas de compuestos aporfínicos. Cassels, B.K.; Asencio, M. BookSection (2005)
Synthesis of peptide mimetics and their building blocks Cassels, B.K.; Sáez, P. BookSection (2005)
Recent developments in the chemistry and pharmacology of boldo and boldine. Cassels, B.K. BookSection (1998)
Alkaloids from Guatteria Cavé, A.; Lebœuf, M.; Cassels, B.K. BookSection (1989)


Synthesis and evaluation of N 1-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands Pérez E.G.; Cassels, B.K.; Eibl C.; Gundisch D. ConferencePaper BIOORGANIC AND MEDICINAL CHEMISTRY (2012)


Erratum: The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death (Biochemical and Biophysical Research Communications (2015) 463:4 (787-792) DOI:10.1016/j.bbrc.2015.06.014) Mena N. P.; García-Beltrán O.; Lourido F.; Urrutia P.J.; Mena, R; Castro-Castillo, V; Cassels, B.K.; Núñez M.T. Errata ISI SCOPUS (2016)
Erratum: Hydrogen-bonded supramolecular array in the crystal structure of ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate monohydrate (Journal of the Chilean Chemical Society (2011) 56:1 (546-548)) GaldÃ¡mez A.; GarcÃa-BeltrÃ¡n O.; Cassels, B.K. Errata SCOPUS Journal of the Chilean Chemical Society (2011)


Distinguishing rotamers in N-trifluoroacetyl-3-benzazepine derivatives Acevedo-Fuentes W.A.; Cassels, B.K. Letter ISI SCOPUS (2016)


DISEÑO Y SÍNTESIS DE LIGANDOS DIRIGIDOS A UN NUEVO RECEPTOR NICOTÍNICO DE ACETILCOLINA (RNACO) HETEROMÉRICO ALFA7BETA2 FONDECYT (3170061) Proyecto 2017-2020 Inv. Patrocinante
MOLECULAR DETERMINANTS OF AFFINITY AND EFFICACY IN SUPERPOTENT 5-HT2 RECEPTOR LIGANDS FONDECYT (1150868) Proyecto 2015-2019 Inv. Responsable
TOTAL SYNTHESIS OF POTENTIALLY BIOACTIVE DIBENZOFURAN DERIVATIVES=> THE ALKALOID EPIMEDIPHINE, NOVEL DIBENZOFURAN EMBEDDED APORPHINES AND MEDIUM-RING AZAHETEROCYCLES FONDECYT (3150474) Proyecto 2014-2016 Inv. Patrocinante
Bases para el aprovechamiento sustentable de las hojas medicinales de Peumus boldus y Cryptocarya alba CONAF (055/2013) Proyecto 2013-2016 Inv. Responsable
DISRUPTION OF THE OXIDATIVE STRESS-IRON ACCUMULATION CYCLE AS A STRATEGY FOR DECREASING DOPAMINERGIC NEURON DEATH IN EXPERIMENTAL MODELS OF PARKINSON S DISEASE. FONDECYT (1130068) Proyecto 2013-2017 Coinvestigador(a)
ESTUDIO DE FOTOISOMERIZACION CIS-TRANS Y COMPORTAMIENTO FOTOCROMICO DE UN NUEVO MATERIAL FOTOSENSIBLE DERIVADO DE DIAZENILBENZOTIOFENO. FONDECYT (3130557) Proyecto 2012-2015 Inv. Patrocinante
HALOGEN BONDS IN DRUG DESIGN=> EXAMPLES IN THE MONOAMINERGIC AREA FONDECYT (1110146) Proyecto 2011-2015 Inv. Responsable
SYNTHESIS OF ENANTIOMERICALLY PURE TETRAHYDROISOQUINOLINES WITH A POTENTIAL ROLE IN THE BIOCHEMICAL BASIS OF ALCOHOLISM. FONDECYT (3100059) Proyecto 2009-2013 Inv. Patrocinante
HIGHLY FUNCTIONALIZED NATURAL PENTACYCLIC TRITERPENOIDS=> STRUCTURAL MODIFICATION AND MEDICINAL CHEMISTRY FONDECYT (1080174) Proyecto 2008-2011 Inv. Responsable
PROSPECTIVE BEHAVIOURAL CHARACTERIZATION OF PUTATIVE ENTACTOGENIC PHENYLALKYLAMINES WITH POSSIBLE APPLICATION IN PSYCHOTERAPY. FONDECYT (1085051) Proyecto 2008-2010 Coinvestigador(a)
MONOAMINE OXIDASE INHIBITORS. bINDING MODE, RATIONAL DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION BASED ON THE ENZYMES CRYSTAL STRUCTURES FONDECYT (1060199) Proyecto 2006-2009 Coinvestigador(a)
DESIGN, SYNTHESIS AND EVALUATION OF POSSIBLE SUBTYPE-SELECTIVE AGONITS AND ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS. FONDECYT (7050013) Proyecto 2005-2006 Inv. Responsable
DESIGN, SYNTHESIS AND EVALUATION OF POSSIBLE SUBTYPE-SELECTIVE AGONITS AND ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS. FONDECYT (1040776) Proyecto 2004-2008 Inv. Responsable
BASES CELULARES Y MOLECULARES DE LOS PROCESOS NEURODEGENERATIVOS=> UNA VISION INTEGRATIVA DESDE LA PERSPECTIVA DEL CITOESQUELETO NEURONAL FONDECYT (1020155) Proyecto 2002-2005 Coinvestigador(a)
PHENETHYLAMINE AS FOR EXPLORING THE MAO ACTIVE SITE FONDECYT (1000776) Proyecto 2000-2003 Inv. Responsable
DISENO RACIONAL DE INHIBIDORES Y SUSTRATOS SUBVERSIVOS DE LA TRIPANOTION REDUCTASA FONDECYT (1950301) Proyecto 1995-1998 Inv. Responsable
PROPIEDADES CITOPROTECTORAS Y DESTINO METABOLICO DE LA BOLDINA=> UN ANTIOXIDANTE DE ORIGEN NATURAL. FONDECYT (1950258) Proyecto 1995-1998 Coinvestigador(a)
RELACIONES ENTRE ESTRUCTURA QUIMICA Y ACTIVIDAD FARMACOLOGICA DE MOLECULAS QUE ACTUAN SOBRE LA NEUROTRANSMISION MONOAMINERGICA. FONDECYT (1890915) Proyecto 1989-1992 Inv. Responsable
DETERMINACION MECANICO-CUANTICA Y COMPUTACIONAL DE LA ESTRUCTURA DE RECEPTORES Y FARMACOFOROS DE INTERES FARMACOLOGICO. FONDECYT (1851075) Proyecto 1985-1986 Coinvestigador(a)


Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia? Herrera-Marschitz, M; Perez-Lobos, R; Lespay-Rebolledo, C; Tapia-Bustos, A; Casanova-Ortiz, E; Morales, P; Valdes, JL; Bustamante, D; Cassels, BK Review ISI NEUROTOXICITY RESEARCH (2018)
Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors Pérez E.G.; Mendez-Galvez, C; Cassels, B.K. Review ISI SCOPUS Natural Product Reports (2012)
Alkaloids from the genus Duguetia. PÂŽrez E.G.; Cassels, B.K. Review SCOPUS The Alkaloids. Chemistry and biology (2010)
From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research Cassels, BK; Bermudez I.; Dajas, F; Abin-Carriquiry, JA; Wonnacott, S Review ISI SCOPUS DRUG DISCOVERY TODAY (2005)

239

Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

Carla Delporte

Profesor titular

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD CIENCIAS QUÍMICAS Y FARMACÉUTICAS

SANTIAGO, Chile

Cristian Suárez

Investigador Postdoctoral Fondecyt Postdoctorado 2022 N° 3220509

Universidad del Desarrollo

Santiago, Chile

Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

osvaldo yañez

Académico Investigador

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

Cristian Tirapegui

Académico

Universidad Autonoma de Chile

Santiago, Chile

Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Iriux Almodóvar

Académico

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

William Tiznado

Full professor

Chemical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Vicente Castro

Associate Professor

Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

Santiago, Chile

Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

Hernan Speisky

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

Edwar Fuentes

Académico jornada completa

Química Inorgánica y Analítica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Pabla Aguirre

Asistente de investigación

Biología

Universidad de Chile

Santiago, Chile

Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

Claudia Yáñez

académico

Química Orgánica y Físico Química

Universidad de Chile

Santiago, Chile

Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

Javier Echeverría

Profesor Asistente e Investigador

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago de Chile, Chile

EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Maria Theoduloz

Planta Profesional

UNIVERSIDAD DE TALCA

Talca, Chile

Ady Giordano

Profesor Asistente

Química

Pontificia Universidad Católica de Chile

Santiago, Chile

María Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

EDUARDO SOBARZO

Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

José Salgado

Associate Professor

Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

Felipe Leyton

Susan Lühr

Profesor Asistente

Química

Universidad de Chile

Santiago, Chile

Luis Vilches

Académico

Universidad de Chile

Chile

Pamela Urrutia

Profesor Asistente

Universidad de Chile

Santiago, Chile

Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Paulina Pavez

Associate Professor

Physical Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Monica Acevedo

Profesor Asistente

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE

Santiago, Chile

Maite Rodriguez

Profesor Jornada

Farmacia

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Lina Ruiz

Academico Docente Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Sebastián Fuentes

Investigador Postdoctoral

Institulo de Ciencias Biomédicas - Instituto de investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

Edison Osorio

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Natalia Martínez

Investigador Postdoctoral

Química

Pontificia Universidad Católica de Chile

Santiago, Chile

José Santos

Professor

Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

ANTONIO GALDAMEZ

ASSOCIATE PROFESSOR

CHEMISTRY

DEPARTAMENTO DE QUÍMICA, FACULTAD DE CIENCIA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Gabriela Valenzuela

Profesor del Laboratorio de Productos Naturales

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

Gloria Montenegro

Profesor Titular

Departamento Ciencias Vegetales

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Patricio Pérez

Asistant Project Scientist

Botany and Plant Science

University of California, Riverside

Riverside, Estados Unidos

Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

Pablo Jaque

Profesor Asociado

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

Andrea Tapia

Profesor adjunto

Facultad de Farmacia

Universidad de Valparaíso

valparaiso, Chile

Bruce Kennedy Cassels Niven

Líneas de Investigación

Educación

Química, Universidad de Buenos Aires. Argentina, 1966

Experiencia Académica

Profesor Titular Part Time

Profesor Titular Full Time

Profesor Full Time

Profesor Full Time

Professeur Associé Full Time

Visiting Scientist Full Time

Professeur Associé Full Time

Visiting Lecturer Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Cátedra Presidencial en Ciencias

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