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María Elena Quintanilla González

PROFESOR ASOCIADO

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

Alcohol intake; Pharmacology; Drug Dependence; Alcoholism, animal models ; Mechanism of alcohol actions; Gene delivery and phage display libraries; Farmacologia (Neurofarmacologia); Neuroquimica; Neurociencias; Gene Therapy of Alcoholism; Mechanisms of Alcohol Addiction; Vectors for Gene Therapy; Alcoholism; Gene Therapy; Genes mitocondriales y nucleares en la aversión al etanol

Ciencias Biomédicas. Mención Farmacología, UNIVERSIDAD DE CHILE. Chile, 1988

Profesor Asociado Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1974 - 1984
profesor Asociado Part Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1984 - A la fecha

Beca de perfeccionamiento Full Time

Philips Universität Marburg

Marburg, Alemania

1982 - 1983

MEMORIAS DIRIGIDAS COMO PROFESOR RESPONSABLE CONDUCENTES A GRADO O TÍTULO

- AUTOR(ES) : Valdivia Garcés, Freddy Antonio
- TÍTULO : Síntesis de isosalsolinol y su purificación por HPLC preparativo
- PROFESORES GUÍA: Quintanilla González, María Elena; Rivera Meza, Mario
- TEMA : Alcaloides de salsolina; Cromatografía líquida de alto rendimiento
-AÑO : 2014

-AUTOR(ES) : Daniella maureira Moreno
-TÍTULO : Purificación de la deshidrogenasa aldehídica mitocondrial
- PROFESOR GUÍA : Quintanilla González, María Elena. Sapag Muñoz de la Peña Amalia
- TEMA :Purificación cromatógrafica de aldehído deshidrogenasa de bacterias. Determinación de Km y Vmáx.

- AUTOR(ES) : Pérez Campos, Elizabeth.
- TÍTULO : Efecto del baclofeno sobre el consumo de alcohol o sacarina y sobre la toelrancia al etanol en ratas bebedoras
- PROFESOR GUÍA : Quintanilla González, María Elena; Tampier de Jong, Luske
- TEMA : Consumo de bebidas alcoholicas.; Sacarina.; Baclofeno.
- AÑO : 2007

TESIS DIRIGIDAS DE MAGISTER COMO PROFESOR RESPONSABLE

- AUTOR(ES) : Callejas Maldonado, Orlando
- TÍTULO : Diferente sensibilidad de las ratas UChA y UChB a los efectos aversivos del etanol y acetaldehído
- PROFESOR GUÍA : Quintanilla González, María Elena
- TEMA : Metabolismo cerebral del etanol,; Farmacocinética del acetaldehído; Consumo de alcohol
- AÑO : 2000

1.- Difusión en reuniones realizadas en SENDA (2015 y 2016) de los estudios realizados en el proyecto Fondecyt # 1130012 sobre bases moleculares de nuevas estrategias en el tratamiento del alcoholismo (Investigador responsable: María Elena Quintanilla).

2.- Demostración Experimental a alumnas del Liceo Nº1, sobre determinación de alcoholemias por cromatografía gaseosa.

3.- Difusión en la página Web de la Facultad de Medicina y de la Universidad de Chile sobre los objetivos del proyecto Fondecyt Nº 1130012 (7 Mayo, 2013)


Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats. Ezquer F, Quintanilla ME, Morales P, Ezquer M, Lespay-Rebolledo C, Herrera-Marschitz M, Israel Y. Article Addict Biol (2018)
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine Israel, Yedy Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2018)
Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking Elena Quintanilla, Mara; Santapau, Daniela; Israel, Yedy Article ISI SCOPUS Scientific Reports (2018)
Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line Israel, Y;Karahanian E;Ezquer F; Morales P; Ezquer M, Rivera-Meza, M; Herrera-Marschitz, M; Quintanilla, ME Article X FRONTIERS IN BEHAVIORAL NEUROSCIENCE (ISI) (2017)
Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats Israel, Y; Ezquer, F; Quintanilla, ME; Morales, P; Ezquer, M; Herrera-Marschitz M Article ISI ALCOHOL AND ALCOHOLISM (2017)
Racemic Salsolinol and its Enantiomers Act as Agonists of the mu-Opioid Receptor by Activating the Gi Protein-Adenylate Cyclase Pathway Berrios-Carcamo, P; Quintanilla, ME; Herrera-Marschitz, M; Vasiliou, V; Zapata-Torres, G; Rivera-Meza, M Article X FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2017)
(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake Quintanilla, ME; Rivera-Meza, M; Berrios-Carcamo, P; Cassels, BK; Herrera-Marschitz, M; Israel, Y Article ISI SCOPUS ADDICTION BIOLOGY (2016)
Beyond the "First Hit": Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation Quintanilla M.E.; Israel, Y Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2016)
Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat Sapag, A; Irrazabal, T; Lobos-Gonzalez, L; Munoz-Brauning, CR; Quintanilla, ME; Tampier, L Article MOLECULAR THERAPY-NUCLEIC ACIDS (2016)
Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats Karahanian, E; Rivera-Meza, M; Tampier, L; Quintanilla, ME; Herrera-Marschitz, M; Israel, Y Article X Addiction Biology (2015)
The "First Hit" Toward Alcohol Reinforcement: Role of Ethanol Metabolites Israel, Y; Quintanilla, ME; Karahanian, E; Rivera-Meza, M; Herrera-Marschitz, M Article FRONTIERS IN BEHAVIORAL NEUROSCIENCE (ISI) (2015)
Fenofibrate - A lipid-lowering drug - Reduces voluntary alcohol drinking in rats Karahanian, E; Fernández K.; Israel, Y Article ISI SCOPUS ALCOHOL (2014)
Overexpression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels into the Ventral Tegmental Area Increases the Rewarding Effects of Ethanol in UChB Drinking Rats Rivera-Meza, M; Bustamante D.; Delgado, R; Buscaglia M.; Herrera-Marschitz, M Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2014)
Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake. Quintanilla ME, Rivera-Meza M, Berrios-Cárcamo PA, Bustamante D, Buscaglia M, Morales P, Karahanian E, Herrera-Marschitz M, Israel Y Article ALCOHOL (2014)
The Alcohol Deprivation Effect: Marked Inhibition by Anticatalase Gene Administration into the Ventral Tegmental Area in Rats Tampier, L; Karahanian, E; Rivera-Meza, M; Herrera-Marschitz, M; Israel, Y Article ISI SCOPUS Alcoholism: Clinical and Experimental Research (2013)
Varenicline and cytisine: two nicotinic acetylcholine receptor ligands reduce ethanol intake in University of Chile bibulous rats Sotomayor-Zarate, R; Gysling, K; Tampier, L Article ISI SCOPUS Psychopharmacology (2013)
Reduction of Ethanol Consumption in Alcohol-Preferring Rats by Dual Expression Gene Transfer Rivera-Meza, M; Quintanilla M.E.; Tampier, L Article ISI SCOPUS Alcohol and Alcoholism (2012)
Reward and Relapse: Complete Gene-Induced Dissociation in an Animal Model of Alcohol Dependence Quintanilla M.E.; Tampier, L; Karahanian, E; Rivera-Meza, M; Herrera-Marschitz, M; Israel, Y Article ISI SCOPUS Alcoholism: Clinical and Experimental Research (2012)
Acetaldehyde Burst Protection of ADH1B*2 Against Alcoholism: An Additional Hormesis Protection Against Esophageal Cancers Following Alcohol Consumption? Israel, Y; Rivera-Meza, M; Sapag, A; Tampier, L Article ISI SCOPUS Alcoholism: Clinical and Experimental Research (2011)
Ethanol as a Prodrug: Brain Metabolism of Ethanol Mediates its Reinforcing Effects Karahanian, E; Tampier, L; Rivera-Meza, M; Bustamante D.; Gonzalez-Lira, V; Morales P.; Herrera-Marschitz, M; Israel, Y Article ISI SCOPUS Alcoholism: Clinical and Experimental Research (2011)
Place conditioning with ethanol in rats bred for high (UChB) and low (UChA) voluntary alcohol drinking Tampier, L Article ISI SCOPUS Alcohol (2011)
Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model Rivera-Meza, M; Tampier, L; Mura, CV; Sapag, A; Israel, Y Article ISI SCOPUS FASEB Journal (2010)
Effect of concurrent saccharin intake on ethanol consumption by high-alcohol-drinking (UChB) rats Tampier, L Article ISI SCOPUS ADDICTION BIOLOGY (2009)
Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat Sapag, A; Gonzalez-Martinez, G; Lobos-Gonzalez, L.; Encina G.; Tampier, L; Israel, Y Article ISI SCOPUS PHARMACOGENETICS AND GENOMICS (2009)
Baclofen reduces ethanol intake in high-alcohol-drinking University of Chile bibulous rats Perez. E; Tampier, L Article ISI SCOPUS ADDICTION BIOLOGY (2008)
Ethanol induces stronger dopamine release in nucleus accumbens (shell) of alcohol-preferring (bibulous) than in alcohol-avoiding (abstainer) rats Bustamante D.; Tampier, L; Gonzalez-Lira, V; Israel, Y; Herrera-Marschitz, M Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
Gene therapy reduces ethanol intake in an animal model of alcohol dependence Ocaranza, P; Tampier, L; Karahanian, E; Sapag, A; Israel, Y Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2008)
Tolerance to disulfiram induced by chronic alcohol intake in the rat Tampier, L; Israel, Y Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2008)
Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol Bustamante D.; Tampier, L; Israel, Y; Herrera-Marschitz, M Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective Tampier, L; Sapag, A; Gerdtzen, Z; Israel, Y Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Combined effects of aldehyde dehydrogenase variants and maternal mitochondrial genes on alcohol consumption Israel, Y; Sapag, A; Tampier, L Article ISI ALCOHOL RESEARCH & HEALTH (2006)
Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats Tampier, L; Valle-Prieto, A; Sapag, A; Israel, Y Article ISI SCOPUS FASEB JOURNAL (2005)
Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats Tampier, L; Sapag, A; Israel, Y Article ISI SCOPUS PHARMACOGENETICS AND GENOMICS (2005)
Saccharin consumption and the effect of a long-term exposure to a sweetened alcoholic solution in high- (UChB) and low- (UChA) alcohol-drinking rats Tampier, L Article ISI ALCOHOL (2005)
Acetaldehyde-reinforcing effects: differences in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats Tampier, L Article ISI SCOPUS ALCOHOL (2003)
Brain mitochondrial aldehyde dehydrogenase: relation to acetaldehyde aversion in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats Tampier, L Article ISI SCOPUS ADDICTION BIOLOGY (2003)
Involvement of brain ethanol metabolism on acute tolerance development and on ethanol consumption in alcohol-drinker (UChB) and non-drinker (UChA) rats Tampier, L Article ISI SCOPUS ADDICTION BIOLOGY (2003)
Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats Sapag, A; Tampier, L; Valle-Prieto, A; Moncada, C; Israel, Y Article ISI SCOPUS PHARMACOGENETICS (2003)
Aversion to acetaldehyde: Differences in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats Callejas, O; Tampier, L Article ISI SCOPUS ALCOHOL (2002)
Effect of a dose of ethanol on acute tolerance and ethanol consumption in alcohol drinker( UChB) and non-drinker (UChA) rats Tampier, L Article ISI SCOPUS ADDICTION BIOLOGY (2002)
Effect of acetaldehyde on acute tolerance and ethanol consumption in drinker and nondrinker rats Tampier, L Article ISI SCOPUS JOURNAL OF STUDIES ON ALCOHOL (2002)
Differences in sensitivity to the aversive effects of ethanol in low-alcohol drinking (UChA) and high-alcohol drinking (UChB) rats Callejas, O; Tampier, L Article ISI SCOPUS ALCOHOL (2001)
Acute tolerance, alcohol sensitivity and drinking pattern in the F2 generation of UChA and UChB rats Tampier, L; Mardones, J Article ISI SCOPUS JOURNAL OF STUDIES ON ALCOHOL (2000)
Effect of naltrexone on acute tolerance to ethanol in UChB rats Tampier, L Article ISI SCOPUS ALCOHOL (2000)
Effect of low doses of ethanol on spontaneous locomotor activity in UChB and UChA rats Quintanilla M.E. Article ADDICTION BIOLOGY (1999)
Effect of nicotinamide administration on ethanol consumption and on liver and brain acetaldehyde oxidation rate, by UChB rats Tampier L, Quintanilla ME, Mardones J Article Addiction Biology (1999)
Oxidation of acetaldehyde by isolated aortic rings of UChA and UChB rats Quintanilla M.E.; Tampier, L Article ADDICTION BIOLOGY (1999)
Effects of bromocriptine on the voluntary consumption of ethanol, water, and solid food by UChA and UChB rats Mardones, J; Quintanilla M.E. Article Alcohol (1996)
Acetaldehyde metabolism by brain mitochondria from UChA and UChB rats Quintanilla ME, Tampier L Article ALCOHOL (1995)
Effects of aminotriazole on ethanol, water, and food intake and on brain catalase in UChA and UChB rats Article ALCOHOL (1995)
Acetaldehyde metabolism: differences between UChA and UChB rats. Article ALCOHOL AND ALCOHOLISM (1994)
Effect of diet and disulfiram on acetaldehyde blood levels after ethanol in UChA and UChB rats. Quintanilla ME, Sepúlveda S, Tampier L Article ALCOHOL (1993)
Metabolism of acetaldehyde by rat isolated aortic rings: Does endothelial tissue contribute to its extrahepatic metabolism? Tampier L, Cariz S. Quintanilla ME Article ALCOHOL (1993)
Ethanol intake: effect on liver and brain mitochondrial function and acetaldehyde oxidation Article ALCOHOL (1992)
Acetaldehyde metabolism by isolated hepatic mitochondria from rats consuming different amounts of ethanol. Article TOXICOLOGY (1990)
The effects of alpha-methyl-p-tyrosine pretreatment on ethanol-induced narcosis and hypothermia, as well as in the development of tolerance to these effects in UChA and UChB rats Tampier L, Zambrano V, Quintanilla ME Article ALCOHOL (1990)
Effect of different treatment regimens with ethanol and p-chlorophenylalanine on tolerance development in UChA and UChB rats Tampier L, Urrutia C, Quintanilla ME. Article ALCOHOL (1988)
Effects of diets decreasing ethanol consumption on acetaldehyde metabolism in UChA and UChB rats. Tampier L, Quintanilla ME, Mardones J Article ALCOHOL AND ALCOHOLISM (1985)


COMBINED INHIBITION OF REWARD AND CONDITIONING PREVENTS RELAPSE IN AN ANIMAL MODEL OF ALCOHOL DEPENDENCE Karahanian, E; Tampier, L; Rivera-Meza, M; Herrera-Marschitz, M; Israel, Y Abstract Alcoholism Clinical and Experimental Research (2012)
ACETALDEHYDE PROTECTS AGAINST ALCOHOLISM BUT IT ALSO PLAYS A ROLE IN THE DEVELOPMENT OF TOLERANCE AND DEPENDENCE Tampier, L; Rivera M.; Sapag, A; Israel, Y Abstract Alcoholism Clinical and Experimental Research (2010)
MICROINJECTION OF AN ANTI-CATALASE SHRNA-CODING LENTIVIRAL VECTOR INTO BRAIN VENTRAL TEGMENTAL AREA (VTA) VIRTUALLY ABOLISHES ETHANOL INTAKE BY RATS BRED AS HIGH ALCOHOL DRINKERS Karahanian, E; Tampier, L; Bustamante D.; Gonzalez-Lira, V; Morales P.; Herrera-Marschitz, M; Israel, Y Abstract Alcoholism Clinical and Experimental Research (2010)
THE ACETALDEHYDE BURST: IT TAKES TWO TO TANGO Israel, Y; Rivera M.; Sapag, A; Tampier, L Abstract Alcoholism Clinical and Experimental Research (2009)


PPAR? agonists reduce alcohol drinking: Do they act in the brain or in the liver? Karahanian, E; Quintanilla M.E.; Muñoz D; Fernández K.; Israel, Y Letter ISI SCOPUS Alcohol and Alcoholism (2015)


Expression vectors which inhibit synthesis of catalase and uses thereof Patent (2012)
Composición inyectable o intranasal que comprende células madres mesenquématicas (MSCs) sin estimular o precondicionadas, medios de cultivo derivados de MSCs precondicionadas o exososmas derivados de su cultivo, y excipientes; y su uso para reducir consumo de drogas o bloquear recaída por privación, en personas con adicción. Patent


Ethanol as a prodrug Karahanian, Eduardo. Tampier, Lutske. Herrera-Marschitz, Mario. Quintanilla, María Elena Proyecto duración 4 años (4)
Genes mitocondriales y nucleares en la adversión al etanol Sapag, Amalia. Tampier, Lutske. Israel, Yedy. Proyecto (3)
Rewarding molecules generated from ethanol in the brain. Karahanian, Eduardo. Herrera-Marschitz, Mario; Rivera-Meza, Mario. Israel, Yedy. Proyecto duración 3 años (3)


Gene specific modifications unravel ethanol and acetaldehyde actions Israel, Y; Rivera-Meza, M; Karahanian, E; Tampier, L; Morales P.; Herrera-Marschitz, M Review ISI SCOPUS Frontiers in Behavioral Neuroscience (2013)
The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake Israel, Y; Sapag, A; Tampier, L Review ISI ADDICTION BIOLOGY (2006)

Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

Ricardo Delgado

Profesor Adjunto

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGIA

Santiago, Chile

Ziomara Gerdtzen

Profesora Asociada

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

María Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Marianne Buscaglia

Estudiante de Doctorado en Ciencias Biológicas, mención Genética Molecular y Microbiología

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Katia Fernández

Académico - Profesor Asociado

Facultad de Salud y Odontología

Universidad Diego Portales

Santiago, Chile

Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

María Elena Quintanilla González

Líneas de Investigación

Educación

Ciencias Biomédicas. Mención Farmacología, UNIVERSIDAD DE CHILE. Chile, 1988

Experiencia Académica

Profesor Asociado Full Time

profesor Asociado Part Time

Experiencia Profesional

Beca de perfeccionamiento Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (58)

Abstract (4)

Letter (1)

Patent (2)

Proyecto (3)

Review (2)