Man

Maria Elena Quintanilla González

PROFESOR ASOCIADO

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

Líneas de Investigación


Alcohol intake; Pharmacology; Drug Dependence; Alcoholism, animal models ; Mechanism of alcohol actions; Gene delivery and phage display libraries; Farmacologia (Neurofarmacologia); Neuroquimica; Neurociencias; Gene Therapy of Alcoholism; Mechanisms of Alcohol Addiction; Vectors for Gene Therapy; Alcoholism; Gene Therapy; Genes mitocondriales y nucleares en la aversión al etanol

Educación

  •  Ciencias Biomédicas. Mención Farmacología, UNIVERSIDAD DE CHILE. Chile, 1988

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1974 - 1984

  •   profesor Asociado Part Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1984 - A la fecha

Experiencia Profesional

  •   Beca de perfeccionamiento Full Time

    Philips Universität Marburg

    Marburg, Alemania

    1982 - 1983

Formación de Capital Humano


MEMORIAS DIRIGIDAS COMO PROFESOR RESPONSABLE CONDUCENTES A GRADO O TÍTULO

- AUTOR(ES) : Valdivia Garcés, Freddy Antonio
- TÍTULO : Síntesis de isosalsolinol y su purificación por HPLC preparativo
- PROFESORES GUÍA: Quintanilla González, María Elena; Rivera Meza, Mario
- TEMA : Alcaloides de salsolina; Cromatografía líquida de alto rendimiento
-AÑO : 2014

-AUTOR(ES) : Daniella maureira Moreno
-TÍTULO : Purificación de la deshidrogenasa aldehídica mitocondrial
- PROFESOR GUÍA : Quintanilla González, María Elena. Sapag Muñoz de la Peña Amalia
- TEMA :Purificación cromatógrafica de aldehído deshidrogenasa de bacterias. Determinación de Km y Vmáx.

- AUTOR(ES) : Pérez Campos, Elizabeth.
- TÍTULO : Efecto del baclofeno sobre el consumo de alcohol o sacarina y sobre la toelrancia al etanol en ratas bebedoras
- PROFESOR GUÍA : Quintanilla González, María Elena; Tampier de Jong, Luske
- TEMA : Consumo de bebidas alcoholicas.; Sacarina.; Baclofeno.
- AÑO : 2007

TESIS DIRIGIDAS DE MAGISTER COMO PROFESOR RESPONSABLE

- AUTOR(ES) : Callejas Maldonado, Orlando
- TÍTULO : Diferente sensibilidad de las ratas UChA y UChB a los efectos aversivos del etanol y acetaldehído
- PROFESOR GUÍA : Quintanilla González, María Elena
- TEMA : Metabolismo cerebral del etanol,; Farmacocinética del acetaldehído; Consumo de alcohol
- AÑO : 2000


Difusión y Transferencia


1.- Difusión en reuniones realizadas en SENDA (2015 y 2016) de los estudios realizados en el proyecto Fondecyt # 1130012 sobre bases moleculares de nuevas estrategias en el tratamiento del alcoholismo (Investigador responsable: María Elena Quintanilla).

2.- Demostración Experimental a alumnas del Liceo Nº1, sobre determinación de alcoholemias por cromatografía gaseosa.

3.- Difusión en la página Web de la Facultad de Medicina y de la Universidad de Chile sobre los objetivos del proyecto Fondecyt Nº 1130012 (7 Mayo, 2013)



 

Article (58)

Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats.
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine
Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking
Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line
Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats
Racemic Salsolinol and its Enantiomers Act as Agonists of the mu-Opioid Receptor by Activating the Gi Protein-Adenylate Cyclase Pathway
(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake.
Beyond the "First Hit": Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation
Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat
Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats
The "First Hit" Toward Alcohol Reinforcement: Role of Ethanol Metabolites
Fenofibrate - A lipid-lowering drug - Reduces voluntary alcohol drinking in rats
Overexpression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels into the Ventral Tegmental Area Increases the Rewarding Effects of Ethanol in UChB Drinking Rats
Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake.
The Alcohol Deprivation Effect: Marked Inhibition by Anticatalase Gene Administration into the Ventral Tegmental Area in Rats
Varenicline and cytisine: two nicotinic acetylcholine receptor ligands reduce ethanol intake in University of Chile bibulous rats
Reduction of Ethanol Consumption in Alcohol-Preferring Rats by Dual Expression Gene Transfer
Reward and Relapse: Complete Gene-Induced Dissociation in an Animal Model of Alcohol Dependence
Acetaldehyde Burst Protection of ADH1B*2 Against Alcoholism: An Additional Hormesis Protection Against Esophageal Cancers Following Alcohol Consumption?
Ethanol as a Prodrug: Brain Metabolism of Ethanol Mediates its Reinforcing Effects
Place conditioning with ethanol in rats bred for high (UChB) and low (UChA) voluntary alcohol drinking
Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model
Effect of concurrent saccharin intake on ethanol consumption by high-alcohol-drinking (UChB) rats
Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat
Baclofen reduces ethanol intake in high-alcohol-drinking University of Chile bibulous rats
Ethanol induces stronger dopamine release in nucleus accumbens (shell) of alcohol-preferring (bibulous) than in alcohol-avoiding (abstainer) rats
Gene therapy reduces ethanol intake in an animal model of alcohol dependence
Tolerance to disulfiram induced by chronic alcohol intake in the rat
Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol
Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective
Combined effects of aldehyde dehydrogenase variants and maternal mitochondrial genes on alcohol consumption
Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats
Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats
Saccharin consumption and the effect of a long-term exposure to a sweetened alcoholic solution in high- (UChB) and low- (UChA) alcohol-drinking rats
Acetaldehyde-reinforcing effects: differences in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats
Brain mitochondrial aldehyde dehydrogenase: relation to acetaldehyde aversion in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats
Involvement of brain ethanol metabolism on acute tolerance development and on ethanol consumption in alcohol-drinker (UChB) and non-drinker (UChA) rats
Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats
Aversion to acetaldehyde: Differences in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats
Effect of a dose of ethanol on acute tolerance and ethanol consumption in alcohol drinker( UChB) and non-drinker (UChA) rats
Effect of acetaldehyde on acute tolerance and ethanol consumption in drinker and nondrinker rats
Differences in sensitivity to the aversive effects of ethanol in low-alcohol drinking (UChA) and high-alcohol drinking (UChB) rats
Acute tolerance, alcohol sensitivity and drinking pattern in the F2 generation of UChA and UChB rats
Effect of naltrexone on acute tolerance to ethanol in UChB rats
Effect of low doses of ethanol on spontaneous locomotor activity in UChB and UChA rats
Effect of nicotinamide administration on ethanol consumption and on liver and brain acetaldehyde oxidation rate, by UChB rats
Oxidation of acetaldehyde by isolated aortic rings of UChA and UChB rats
Effects of bromocriptine on the voluntary consumption of ethanol, water, and solid food by UChA and UChB rats
Acetaldehyde metabolism by brain mitochondria from UChA and UChB rats
Effects of aminotriazole on ethanol, water, and food intake and on brain catalase in UChA and UChB rats
Acetaldehyde metabolism: differences between UChA and UChB rats.
Effect of diet and disulfiram on acetaldehyde blood levels after ethanol in UChA and UChB rats.
Metabolism of acetaldehyde by rat isolated aortic rings: Does endothelial tissue contribute to its extrahepatic metabolism?
Ethanol intake: effect on liver and brain mitochondrial function and acetaldehyde oxidation
Acetaldehyde metabolism by isolated hepatic mitochondria from rats consuming different amounts of ethanol.
The effects of alpha-methyl-p-tyrosine pretreatment on ethanol-induced narcosis and hypothermia, as well as in the development of tolerance to these effects in UChA and UChB rats
Effect of different treatment regimens with ethanol and p-chlorophenylalanine on tolerance development in UChA and UChB rats
Effects of diets decreasing ethanol consumption on acetaldehyde metabolism in UChA and UChB rats.

Abstract (4)

COMBINED INHIBITION OF REWARD AND CONDITIONING PREVENTS RELAPSE IN AN ANIMAL MODEL OF ALCOHOL DEPENDENCE
ACETALDEHYDE PROTECTS AGAINST ALCOHOLISM BUT IT ALSO PLAYS A ROLE IN THE DEVELOPMENT OF TOLERANCE AND DEPENDENCE
MICROINJECTION OF AN ANTI-CATALASE SHRNA-CODING LENTIVIRAL VECTOR INTO BRAIN VENTRAL TEGMENTAL AREA (VTA) VIRTUALLY ABOLISHES ETHANOL INTAKE BY RATS BRED AS HIGH ALCOHOL DRINKERS
THE ACETALDEHYDE BURST: IT TAKES TWO TO TANGO

Letter (1)

PPAR? agonists reduce alcohol drinking: Do they act in the brain or in the liver?

Patent (2)

Expression vectors which inhibit synthesis of catalase and uses thereof
Composición inyectable o intranasal que comprende células madres mesenquématicas (MSCs) sin estimular o precondicionadas, medios de cultivo derivados de MSCs precondicionadas o exososmas derivados de su cultivo, y excipientes; y su uso para reducir consumo de drogas o bloquear recaída por privación, en personas con adicción.

Proyecto (3)

Ethanol as a prodrug
Genes mitocondriales y nucleares en la adversión al etanol
Rewarding molecules generated from ethanol in the brain.

Review (2)

Gene specific modifications unravel ethanol and acetaldehyde actions
The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake
70
Maria Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

23
Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

9
Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

7
Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

7
Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

5
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

3
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

2
Katia Fernández

Académico - Profesor Asociado

Facultad de Salud y Odontología

Universidad Diego Portales

Santiago, Chile

2
Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

1
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

1
Marianne Buscaglia

Estudiante de Doctorado en Ciencias Biológicas, mención Genética Molecular y Microbiología

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ricardo Delgado

Profesor Adjunto

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGIA

Santiago, Chile

1
Gonzalo Encina

Investigador

Family Gen

Santiago, Chile

1
Ziomara Gerdtzen

Profesora Asociada

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile