Man

Yedy Israel Jacard

Profesor Titular

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

Líneas de Investigación


Alcoholismo, Modelos animales y estudios clinicos, Terapia Genica del alcoholismo, Neurofarmacología ,Diseño experimental, Farmacología de las adicciones, Terapia por celulas madre molecular de la dependencia al alcohol.

Educación

  •  Bioquimica, UNIVERSITY OF TORONTO. Canada, 1965
  •  Bioquimico, UNIVERSIDAD DE CHILE. Chile, 1962

Experiencia Académica

  •   Profesor Titular y Director Addiction Res Foundation Institute and Hospital Full Time

    UNIVERSITY OF TORONTO

    Medicine

    Toronto, Canada

    1970 - 1995

  •   Professor and Co-Direct Alcohol Center Full Time

    JEFFERSON UNIVERSITY

    Medicine

    Philadelphia, Estados Unidos

    1994 - 2002

  •   Profesor Titular Part Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1997 - A la fecha

  •   Profesor Titular y Dir Terapia Genica Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Quimicas y Farmaceuticas

    Santiago, Chile

    1997 - 2013

Experiencia Profesional

  •   Director Full Time

    ADDICTION RESEARCH FOUNDATION CLINICAL INSTITUTE

    Toronto, Canada

    1998 - 1981

  •   Co-Director Part Time

    NIH Alcohol Research Center at Jefferson

    Philadelphia, Estados Unidos

    1999 - 2002

  •   Associate Editor or Editorial Board Member Other

    Addiction Biology and other Journals

    Heidelberg-New Haven- Austin , Estados Unidos

    1989 - A la fecha

Formación de Capital Humano


2016 Benjamin Erranz, Doctorado en Ciencias Biomedicas ( Director, de Doctorado Dr. Yedy Israel)

Esta tesis fue realizada en el Laboratorio de Farmacoterapia Génica bajo la dirección del Dr. Yedy Israel, quien recibió financiamiento para la realización de este proyecto del Instituto nacional de Salud de EE.UU. (Proyecto NIAAA R01-AA015421) y del Instituto de Dinámica Celular y Biotecnología (Proyecto P05-001-F), parte de la Iniciativa Científica Milenio.

Anteriores a 2016: 18 doctorados (9 en Canada o USA)


Difusión y Transferencia


Patentes comercializadas en Canada (3 de 6).


Premios y Distinciones

  •   Distinguished Research Award

    Canada Pharmacological Society Upjohn Award

    Canada, 1979

    Animal Model of Alcoholic liver injury and treatment

  •   Jellinek Alcoholism Award

    The Jellinek International Award Foundation

    Canada, 1980

    Advances in the treatment of Alcoholic liver disease.

  •   President U.S Alcoholism Research Society

    U.S. Research Society on Alcoholism

    Estados Unidos, 1999

    Promoting Alcoholism Research

  •   Miembro Correspondiente

    Academia de Ciencias de Chile

    Chile, 2001

    Desarrolla en Chile el primer centro deTerapia Genica

  •   Alcoholism Award International Society Biomed Res Alcoholism

    International Society for Biomedical Reserach on Alcoholism

    Estados Unidos, 2014

    Alcoholism basic and clinical transference


 

Article (59)

INNATE GUT MICROBIOTA PREDISPOSES TO HIGH ALCOHOL CONSUMPTION
INTRANASAL ADMINISTRATION OF PRECONDITIONED MESENCHYMAL STEM CELL SECRETOME REDUCES OXIDATIVE STRESS, NEUROINFLAMMATION AND CELL DEATH IN HIPPOCAMPUS, ACTIVATING THE NRF2 PATHWAY, IMPROVING BEHAVIORAL AND COGNITIVE DEFICITS INDUCED BY PERINATAL ASPHYXIA
N-ACETYLCYSTEINE AND ACETYLSALICYLIC ACID INHIBIT ALCOHOL CONSUMPTION BY DIFFERENT MECHANISMS: COMBINED PROTECTION
OXIDATIVE STRESS AND NEUROINFLAMMATION AS A PIVOT IN DRUG ABUSE. A FOCUS ON THE THERAPEUTIC POTENTIAL OF ANTIOXIDANT AND ANTI-INFLAMMATORY AGENTS AND BIOMOLECULES
ACTIVATION OF MITOCHONDRIAL ALDEHYDE DEHYDROGENASE (ALDH2) BY ALDA-1 REDUCES BOTH THE ACQUISITION AND MAINTENANCE OF ETHANOL INTAKE IN RATS: A DUAL MECHANISM?
COMMONALITY OF ETHANOL AND NICOTINE REINFORCEMENT AND RELAPSE IN WISTAR-DERIVED UCHB RATS: INHIBITION BY N-ACETYLCYSTEINE
INTRANASAL DELIVERY OF MESENCHYMAL STEM CELL-DERIVED EXOSOMES REDUCES OXIDATIVE STRESS AND MARKEDLY INHIBITS ETHANOL CONSUMPTION AND POST-DEPRIVATION RELAPSE DRINKING
NTRAVENOUS ADMINISTRATION OF ANTI-INFLAMMATORY MESENCHYMAL STEM CELL SPHEROIDS REDUCES CHRONIC ALCOHOL INTAKE AND ABOLISHES BINGE-DRINKING
ACQUISITION, MAINTENANCE AND RELAPSE-LIKE ALCOHOL DRINKING:LESSONS FROM THE UCHB RAT LINE.
ACTIVATED MESENCHYMAL STEM CELL ADMINISTRATION INHIBITS CHRONIC ALCOHOL DRINKING AND SUPPRESSES RELAPSE-LIKE DRINKING IN HIGH-ALCOHOL DRINKER RATS
INTRACEREBRAL STEM CELL ADMINISTRATION INHIBITS RELAPSE-LIKE ALCOHOL DRINKING IN RATS
Beyond the "First Hit": Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation
Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats
The sequenced rat brain transcriptome - its use in identifying networks predisposing alcohol consumption
Fenofibrate - A lipid-lowering drug - Reduces voluntary alcohol drinking in rats
The Alcohol Deprivation Effect: Marked Inhibition by Anticatalase Gene Administration into the Ventral Tegmental Area in Rats
Reward and Relapse: Complete Gene-Induced Dissociation in an Animal Model of Alcohol Dependence
Acetaldehyde Burst Protection of ADH1B*2 Against Alcoholism: An Additional Hormesis Protection Against Esophageal Cancers Following Alcohol Consumption?
Ethanol as a Prodrug: Brain Metabolism of Ethanol Mediates its Reinforcing Effects
Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene
Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model
Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat
RNA interference against aldehyde dehydrogenase-2: development of tools for alcohol research
Ethanol induces stronger dopamine release in nucleus accumbens (shell) of alcohol-preferring (bibulous) than in alcohol-avoiding (abstainer) rats
Tolerance to disulfiram induced by chronic alcohol intake in the rat
Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol
Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective
Combined effects of aldehyde dehydrogenase variants and maternal mitochondrial genes on alcohol consumption
Hereditary hemochromatosis: An opportunity for gene therapy
Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA
Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: Potential application in hemochromatosis
Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats
Genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) in a Chinese population: Gender, age, culture, and genotypes of ALDH2
Inhibition of tumor necrosis factor alpha secretion and prevention of liver injury in ethanol-fed rats by antisense oligonucleotides
Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats
Effects of acute gamma-hexachlorocyclohexane intoxication in relation to the redox regulation of nuclear factor-kappa B cytokine gene expression, and liver injury in the rat
Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells
Binding of acetaldehyde to a glutathione metabolite: Mass spectrometric characterization of an acetaldehyde-cysteinylglycine conjugate
Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats
Use of an acetaldehyde clamp" in the determination of low-K-M aldehyde dehydrogenase activity in H4-II-E-C3 rat hepatoma cells"
Gene and antisense delivery in alcoholism research
Increases in tumor necrosis factor-alpha in response to thyroid hormone-induced liver oxidative stress in the rat
Proteomics in alcohol research
Targeting Kupffer cells with antisense oligonucleotides
The Research Society on Alcoholism
Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol
In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-? in rats
In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-alpha in rats
Protein binding of ?-hydroxyethyl free radicals
Protein binding of alpha-hydroxyethyl free radicals
Selection of phage-display library peptides recognizing ethanol targets on proteins
Paradigm to test a drug-induced aversion to ethanol
Characterization of adducts of ethanol metabolites with cytochrome c
Generation of acetate and production of ethyl-lysine in the reaction of acetaldehyde plus serum albumin
Tetranucleotide GGGA motif in primary RNA transcripts: Novel target site for antisense design
ASPIRIN AND N-ACETYLCYSTEINE CO-ADMINISTRATION MARKEDLY INHIBIT CHRONIC ETHANOL INTAKE AND BLOCK RELAPSE BINGE DRINKING: ROLE OF NEUROINFLAMMATION-OXIDATIVE STRESS SELF-PERPETUATION
INTRANASAL MESENCHYMAL STEM CELL SECRETOME ADMINISTRATION MARKEDLY INHIBITS ALCOHOL AND NICOTINE SELF-ADMINISTRATION AND BLOCKS RELAPSE-INTAKE: MECHANISM AND TRANSLATIONAL OPTIONS
Patents granted in the United States (three commercialized of total of six)
Publications in Canada and United States (Total of 213 not listed)

Abstract (16)

AN ANTICATALASE LENTIVIRAL VECTOR REDUCED ETHANOL INTAKE IN DEVELOPMENTALLY-LEAD-EXPOSED RATS
FENOFIBRATE -A LIPID-LOWERING DRUG-INCREASES BLOOD ACETALDEHYDE LEVELS AND REDUCES VOLUNTARY ALCOHOL DRINKING IN RATS
A CLEAR PARADOX: AVERSIVE EFFECTS OF LIVER-GENERATED ACETALDEHYDE BUT REWARDING/REINFORCING EFFECTS OF ACETALDEHYDE GENERATED IN THE BRAIN
SALSOLINOL, FREE OF ISOSALSOLINOL, EXERTS ETHANOL- LIKE MOTIVATIONAL/SENSITIZATION EFFECTS LEADING TO INCREASES IN ETHANOL INTAKE
ACETALDEHYDE PROTECTS AGAINST ALCOHOLISM BUT IT ALSO PLAYS A ROLE IN THE DEVELOPMENT OF TOLERANCE AND DEPENDENCE
MICROINJECTION OF AN ANTI-CATALASE SHRNA-CODING LENTIVIRAL VECTOR INTO BRAIN VENTRAL TEGMENTAL AREA (VTA) VIRTUALLY ABOLISHES ETHANOL INTAKE BY RATS BRED AS HIGH ALCOHOL DRINKERS
ROLE OF ACETALDEHYDE ON THE MOTIVATIONAL PROPERTIES OF ETHANOL IN RATS BRED AS HEAVY DRINKERS
THE ACETALDEHYDE BURST: IT TAKES TWO TO TANGO
Pharmacogenetic and metabolic factors determining acetaldehyde levels and aversion to ethanol in animals and man
Four complex I proteins encoded in the mitochondrial genome are different in low drinker ucha and high drinker UChB rats
Permissive and protective genes in alcoholism: Yin and Yang. Protection against alcoholism in a genetic model of alcohol dependence
Autosomal and maternal genes influence alcohol intake in alcohol drinker and nondrinker rat lines: Role of the "acetaldehyde burst".
Mitochondrial complex-I and aldehyde dehydrogenase (ALDH2) interactions determine an acetaldehyde burst and ethanol volition in animals: Genetic and pharmacological studies
Administration of an adenoviral vector carrying an ALDH2 antisense gene reduces ALDH2 activity and leads to an accummulation of acetaldehyde in rat hepatoma cells.
Polymorphisms in ALDH2 gene determine differences in peak acetaldehyde levels and voluntary ethanol consumption in rats.
Hemochromatosis: AAV coding an antisense gene against DIVIT-1 iron transporter in intestinal epithelial cells acts as RNAL and inhibits iron transport

BiographicalItem (1)

Dora B. Goldstein - In Memoriam

ConferencePaper (1)

Activation of nuclear factor KB and TNF-alpha response to thyroid hormone-induced liver oxidative stress

Letter (1)

PPAR? agonists reduce alcohol drinking: Do they act in the brain or in the liver?

Review (4)

The "First Hit" Toward Alcohol Reinforcement: Role of Ethanol Metabolites
Gene specific modifications unravel ethanol and acetaldehyde actions
Genetic and Environmental Influences on Ethanol Consumption: Perspectives From Preclinical Research
The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake
83
Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

22
Maria Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

12
Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

11
Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

11
Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

4
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

3
Gonzalo Encina

Investigador

Family Gen

Santiago, Chile

3
Gladys Tapia

Academica

Farmacología Molecular y Clínica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

2
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

2
Katia Fernández

Académico - Profesor Asociado

Facultad de Salud y Odontología

Universidad Diego Portales

Santiago, Chile

2
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

2
Julia Guerrero

académico

Programa Disciplinario Fisiologia y Biofisica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Paulette Conget

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Ziomara Gerdtzen

Profesora Asociada

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

1
Juan Asenjo

Professor

CHEMICAL AND BIOTECHNOLOGY ENGINEERING

University of Chile

SANTIAGO, Chile

1
Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Marianne Buscaglia

Estudiante de Doctorado en Ciencias Biológicas, mención Genética Molecular y Microbiología

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile