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Juan Alfonso Asenjo De Leuze de Lancizolle

Professor

University of Chile

SANTIAGO, Chile

Biochemical Engineering and Biotechnology, Protein Separation, Modelling Biological Systems and Extremophiles.

BIOCHEMICAL ENGINEERING, UNIVERSITY COLLEGE LONDON. Reino Unido, 1978
FOOD ENGINEERING, UNIVERSITY OF LEEDS. Reino Unido, 1977
INGENIERO CIVIL QUIMICO, UNIVERSIDAD DE CHILE. Chile, 1975

PROFESSOR Full Time

UNIVERSIDAD DE CHILE

PHYSICAL AND MATHEMATICAL SCIENCES

SANTIAGO, Chile

1995 - A la fecha
ASSISTANT PROFESSOR Full Time

COLUMBIA UNIVERSITY

BIOCHEMICAL ENGINEERING

NEW YORK, Estados Unidos

1980 - 1984
ASSOCIATE PROFESSOR Full Time

COLUMBIA UNIVERSITY

ENGINEERING

NEW YORK, Estados Unidos

1985 - 1986
READER OF BIOCHEMICAL ENGINEERING Full Time

UNIVERSITY OF READING

SCIENCES

READING, Reino Unido

1987 - 1994

In the past 3 years the thesis directed are:

3 Undergraduate,
Victoria González (2017); Danton Freire (2017); Juan Canales (2015).

1 Master,
Jorge Meza (2017);

7 PhD,
Anamaría Sánchez (2017); José Duguet (2017); Valeria Razmilic (2017); Jaime Peña (2017); Alicia Lucero (2016); Gabriela Sandoval (2016); Jean Franco Castro (2015).

Currents PhD students:
Diego Lagos, Carlos Cortés, Carlos Gomez, Annet Rubio, Francisca Marchant, Diana Saucedo.

Multimedia Educational Workshops for Teachers of Science Mathematics and Science Teaching Media in different regions of the country made November 2010. The objectives of the workshop are to familiarize and train teachers in the use of interactive learning materials in the classroom. Awakening in participants a taste for the application of interactive in the classroom. Disseminate educational materials made by the ICDB.

Explore Program of CONICYT, Regional Conferences Millennium-Explore and Explore-Millennium Talks "Bringing Science to your Commune".

Participation in the National Week of Science and Technology, the largest activity EXPLORE CONICYT Program is held every year and seeks to encourage mass participation and simultaneous assessment activities and dissemination of science and technology in the country .

Has participated in1000 Scientific 1000 Classroom Program of Conicyt in several opportunitis; scientists leave for a day their labs and lectures to attend educational institutions to realize what is scientific research, what is done and what can be done in Chile, sharing his personal experience in the area.

Participation Chapter of the series "VidaConCiencia" program that shows Chilean scientists presented innovative research in the field of health, technology and innovation and how they can be real solutions to human health, and especially Chapter documentary "Mentes Brillantes". This series unvails the life and work of prominent National Science Awards that have left an indelible mark of contemporary national sciences. Both signal emitted by cable Channel 13 during 2011 and 2012 respectively.

The scientific work of the exhibitor and popularizer consists of 144 articles, 114 of them published in international journals and editorial board and 30 correspond to contributions presented at international conferences and published in books and book chapters. He has also been editor of five books, three of which correspond to Congress articles.

NATIONAL SCIENCE PRIZE

MINISTERIO DE EDUCACION

Chile, 2004

FOR CONICYT
ELECTED MEMBER OF CHILEAN ACADEMY OF SCIENCES

ACADEMIA CHILENA DE CIENCIAS

Chile, 1999

EN 1999
PRESIDENCIAL CHAIR IN SCIENCES

MINISTERIO SECRETARIA GENERAL DE LA PRESIDENCIA

Chile, 1997

CÁTEDRA PRESIDENCIAL


Acidithiobacillus ferrooxidans's comprehensive model driven analysis of the electron transfer metabolism and synthetic strain design for biomining applications Vaisman D.; Castro, JF; Razmilic, V; Mercado, F; Andrews B. A.; Asenjo, JA Article SCOPUS Metabolic Engineering Communications (2016)
Analyzing redox balance in a synthetic yeast platform to improve utilization of brown macroalgae as feedstock Shene, C; Olivera, A.; Yoshikuni Y.; Buschmann, A; Andrews B. A.; Asenjo, JA Article SCOPUS Metabolic Engineering Communications (2015)
Identification and Heterologous Expression of the Chaxamycin Biosynthesis Gene Cluster from Streptomyces leeuwenhoekii Castro, Jean Franco; Razmilic, Valeria; Gomez-Escribano, Juan Pablo; Andrews, Barbara; Asenjo, Juan A.; Bibb, Mervyn J.; Elliot, M. A. Article ISI SCOPUS Applied and Environmental Microbiology (2015)
Identification of lipase encoding genes from Antarctic seawater bacteria using degenerate primers: Expression of a cold-active lipase with high specific activity Espina, G; Devia, J; Salazar, O.; Andrews, B; Asenjo, JA Article ISI SCOPUS ENZYME AND MICROBIAL TECHNOLOGY (2015)
Production of Cell-Penetrating Peptides in Escherichia coli Using an Intein-Mediated System Rodríguez, Vida; Lascani, Jorge; Asenjo, Juan A.; ANDREWS, Barbara, A. Article ISI SCOPUS Applied Biochemistry and Biotechnology (2015)
Stoichiometric Model and Flux Balance Analysis for a Mixed Culture of Leptospirillum ferriphilum and Ferroplasma acidiphilum Merino, M. P.; Andrews B. A.; Asenjo, JA Article ISI SCOPUS Biotechnology Progress (2015)
A novel model for biofilm growth and its resolution by using the hybrid immersed interface-level set method Cumsille, P; Asenjo, JA; Conca, C Article ISI COMPUTERS & MATHEMATICS WITH APPLICATIONS (2014)
An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma Gossage, L.; Pires, D. E. V.; Olivera-Nappa, A.; Asenjo, J; Bycroft, M.; Blundell, T. L.; Eisen, T. Article ISI HUMAN MOLECULAR GENETICS (2014)
Streptomyces bullii sp nov., isolated from a hyper-arid Atacama Desert soil Santhanam, R; Rong, XY; Huang, Y; Andrews, BA; Goodfellow M. Article ISI SCOPUS Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology (2013)
Aqueous two-phase systems for protein separation: Phase separation and applications Asenjo, JA; Andrews B. A. Article ISI SCOPUS Journal of Chromatography A (2012)
Continuous modeling of metabolic networks with gene regulation in yeast and in vivo determination of rate parameters Moisset, P; Vaisman D.; Cintolesi, A.; Urrutia, J; Rapaport, I; Andrews B. A.; Asenjo, JA Article ISI SCOPUS Biotechnology and Bioengineering (2012)
Elmer L. Gaden, Jr. Tribute Clark D.S.; Blanch H.W.; Wang D.I.; Demain A.L.; Wandrey C.; Schultz J.S.; Shuler M.L.; Hoare, M; Lightfoot E.N.; Humphrey A.E.; et al. Article SCOPUS Biotechnology and Bioengineering (2012)
Elution relationships to model affinity chromatography using a general rate model Sandoval, G; Andrews B. A.; Asenjo, JA Article ISI SCOPUS Journal of Molecular Recognition (2012)
Hydrophobic interaction chromatography for purification of monoPEGylated RNase A Mayolo-Deloisa K.; Lienqueo M.E.; Andrews, B; Rito-Palomares M.; Asenjo, JA Article ISI SCOPUS Journal of Chromatography A (2012)
Streptomyces atacamensis sp nov., isolated from an extreme hyper-arid soil of the Atacama Desert, Chile Santhanam, R; Rong X.; Huang, Y; Andrews B. A.; Asenjo, JA; Goodfellow M. Article ISI SCOPUS International Journal of Systematic and Evolutionary Microbiology (2012)
Streptomyces deserti sp nov., isolated from hyper-arid Atacama Desert soil Santhanam, R; Rong X.; Huang, Y; Andrews B. A.; Asenjo, JA; Goodfellow M. Article ISI SCOPUS Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology (2012)
Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp C38 Nachtigall J.; Kulik A.; Helaly S.; Bull, AT; Goodfellow M.; Maier, A; Wiese J.; Imhoff, JF; Sussmuth, RD; Fiedler, HP Article ISI SCOPUS Journal of Antibiotics (2011)
Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp. Rateb, ME; Houssen, WE; Arnold, M; Abdelrahman, MH; Deng, H; Harrison, WTA; Okoro, CK; Andrews, BA; Ferguson G.; Bull, AT; et al. Article ISI SCOPUS Journal of Natural Products (2011)
Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment Rateb, ME; Houssen, WE; Harrison, WTA; Deng, H; Okoro, CK; Andrews, BA; Bull, AT; Goodfellow M.; Ebel, R.; Jaspars, M Article ISI SCOPUS Journal of Natural Products (2011)
Identification of Transcription Factors Perturbed by the Synthesis of High Levels of a Foreign Protein in Yeast Saccharomyces cerevisiae Contador CA; Andrews, BA; Liao, JC Article ISI SCOPUS Biotechnology Progress (2011)
Mutagenesis Objective Search and Selection Tool (MOSST): an algorithm to predict structure-function related mutations in proteins Olivera-Nappa, A.; Andrews, BA Article ISI SCOPUS BMC Bioinformatics (2011)
Reducing the allowable kinetic space by constructing ensemble of dynamic models with the same steady-state flux Tan, Y; Rivera, JGL; Contador CA; Liao, JC Article ISI SCOPUS Metabolic Engineering (2011)
Experimental Validation of the Predictions of a Mathematical Model for Protein Purification and Tag Selection Shene, C; Quiroga, A; Salazar, O.; Salgado JC Article ISI SCOPUS Separation Science and Technology (Philadelphia) (2010)
Extension of the selection of protein chromatography and the rate model to affinity chromatography Sandoval, G; Shene, C; Andrews, BA Article ISI SCOPUS Journal of Molecular Recognition (2010)
Metabolic Flux Analysis of Embryonic Stem Cells Using Three Distinct Differentiation Protocols and Comparison to Gene Expression Patterns Sepúlveda, DE; Andrews, BA; Papoutsakis, ET Article ISI SCOPUS Biotechnology progress (2010)
Non-Homogeneous Biofilm Modeling Applied to Bioleaching Processes Olivera-Nappa, A.; Picioreanu C. Article ISI SCOPUS Biotechnology and Bioengineering (2010)
Stoichiometric Model and Metabolic Flux Analysis for Leptospirillum ferrooxidans Merino, MP; Andrews, BA Article ISI SCOPUS Biotechnology and Bioengineering (2010)
Theoretical and Experimental Evaluation of Hydrophobicity of Proteins to Predict their Partitioning Behavior in Aqueous Two Phase Systems: A Review Andrews, BA Article ISI SCOPUS Separation Science and Technology (Philadelphia) (2010)
Viral vectors for the treatment of alcoholism: Use of metabolic flux analysis for cell cultivation and vector production Martínez, V; Andrews, BA Article ISI SCOPUS METABOLIC ENGINEERING (2010)
A Stoichiometric Model of Acidithiobacillus ferrooxidans ATCC 23270 for Metabolic Flux Analysis Hold, C; Andrews, BA Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2009)
Computer-aided design to select optimal polypeptide tags to assist the purification of recombinant proteins Salgado JC; Giaverini, O Article ISI SCOPUS SEPARATION AND PURIFICATION TECHNOLOGY (2009)
Diversity of culturable actinomycetes in hyper-arid soils of the Atacama Desert, Chile Okoro, CK; Brown R.; Jones, AL; Andrews, BA; Goodfellow M.; Bull, AT Article ISI SCOPUS ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2009)
Ensemble modeling for strain development of L-lysine-producing Escherichia coli Contador CA; Rizk, ML; Liao, JC Article ISI SCOPUS METABOLIC ENGINEERING (2009)
Global gene expression in recombinant and non-recombinant yeast Saccharomyces cerevisiae in three different metabolic states Díaz, H; Andrews, BA; Hayes, A; Castrillo, J; Oliver, SG Article ISI SCOPUS BIOTECHNOLOGY ADVANCES (2009)
Mathematical Modeling of Elution Curves for a Protein Mixture in Ion Exchange Chromatography Applied to High Protein Concentration Orellana, CA; Shene, C Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2009)
Modeling heterocyst pattern formation in cyanobacteria Salgado JC; Osses A.; Rapaport, I; Andrews, BA Article ISI SCOPUS BMC Bioinformatics (2009)
Optimization of hydrophobic interaction chromatography using a mathematical model of elution curves of a protein mixture Shene, C; Asenjo, J Article ISI SCOPUS JOURNAL OF MOLECULAR RECOGNITION (2009)
Protein purification using chromatography: selection of type, modelling and optimization of operating conditions Andrews, BA Article ISI SCOPUS JOURNAL OF MOLECULAR RECOGNITION (2009)
Cloning and fusion expression of a cold-active lipase from marine Antarctic origin Parra, LP; Reyes, F; Acevedo, JP; Salazar, O.; Andrews, BA Article ISI SCOPUS ENZYME AND MICROBIAL TECHNOLOGY (2008)
Cloning of complete genes for novel hydrolytic enzymes from Antarctic sea water bacteria by use of an improved genome walking technique Acevedo, JP; Reyes, F; Parra, LP; Salazar, O.; Andrews, BA Article ISI SCOPUS JOURNAL OF BIOTECHNOLOGY (2008)
Comparative Transcriptional Analysis of Embryoid Body Versus Two-Dimensional Differentiation of Murine Embryonic Stem Cells Sepúlveda, DE; Andrews, BA; Papoutsakis, ET Article ISI SCOPUS TISSUE ENGINEERING PART A (2008)
Prediction of the partitioning behaviour of proteins in aqueous two-phase systems using only their amino acid composition Salgado JC; Andrews, BA; Ortuzar, MF Article ISI SCOPUS JOURNAL OF CHROMATOGRAPHY A (2008)
A discrete mathematical model applied to genetic regulation and metabolic networks Ramirez, P; Rapaport, I; Aracena, J; Goles, E; Andrews, BA Article ISI SCOPUS JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2007)
Application of chromatographic theory for process characterization towards validation of an ion-exchange operation Kaltenbrunner, O; Giaverini, O; Woehle, D Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2007)
Optimal opcration conditions for protein separation in hydrophobic interaction chromatography Mahn A. Article ISI SCOPUS JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2007)
Hereditary hemochromatosis: An opportunity for gene therapy Ezquer, F; Rojas, A; Asenjo, J; Israel, Y Article ISI SCIELO BIOLOGICAL RESEARCH (2006)
Improvement of the lytic properties of a ?-1,3-glucanase by directed evolution Salazar, O.; Basso, C; Barba, P; Orellana, C; Asenjo, JA Article MOLECULAR BIOTECHNOLOGY (2006)
Mathematical modeling of elution curves for a protein mixture in ion exchange chromatography and for the optimal selection of operational conditions Shene, C; Lucero A; Andrews, BA Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2006)
New approaches for predicting protein retention time in hydrophobic interaction chromatography Mahn A.; Navarro, G; Salgado JC; Perez-Acle, T; Rapaport, I Article ISI JOURNAL OF MOLECULAR RECOGNITION (2006)
Predicting the behaviour of proteins in hydrophobic interaction chromatography 1: Using the hydrophobic imbalance (HI) to describe their surface amino acid distribution Salgado JC; Rapaport, I Article ISI SCOPUS JOURNAL OF CHROMATOGRAPHY A (2006)
Predicting the behaviour of proteins in hydrophobic interaction chromatography 2. Using a statistical description of their surface amino acid distribution Salgado JC; Rapaport, I Article ISI SCOPUS JOURNAL OF CHROMATOGRAPHY A (2006)
A theory of protein-resin interaction in hydrophobic interaction chromatography Mahn A.; Zapata-Torres, G Article ISI SCOPUS JOURNAL OF CHROMATOGRAPHY A (2005)
Correlation for the partition behavior of proteins in aqueous two-phase systems: Effect of surface hydrophobicity and charge Andrews, BA; Schmidt, AS Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2005)
Is it possible to predict the average surface hydrophobicity of a protein using only its amino acid composition? Salgado JC; Rapaport, I Article ISI SCOPUS JOURNAL OF CHROMATOGRAPHY A (2005)
Prediction of retention times of proteins in hydrophobic interaction chromatography using only their amino acid composition Salgado JC; Rapaport, I Article ISI SCOPUS JOURNAL OF CHROMATOGRAPHY A (2005)
A mixed mechanistic-electrostatic model to explain pH dependence of glycosyl hydrolase enzyme activity Olivera-Nappa, A.; Andrews, BA Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2004)
EFFECT OF ELECTROSTATIC ENERGY ON PARTITIONING OF PROTEINS IN AQUEOUS TWO-PHASE SYSTEMS Olivera-Nappa, A.; Lagomarsino, Gian; Andrews, Barbara; Asenjo, Juan Article JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2004)
Effect of surface hydrophobicity distribution on retention of ribonucleases in hydrophobic interaction chromatography Mahn A. Article ISI SCOPUS JOURNAL OF CHROMATOGRAPHY A (2004)
Optimal process synthesis for the production of multiple recombinant proteins Iribarren, OA; Montagna, JM; Vecchietti, AR; Andrews, B Article ISI BIOTECHNOLOGY PROGRESS (2004)
Erratum: Mathematical correlations for predicting protein retention times in hydrophobic interaction chromatography (Journal of Chromatography A (2002) 978 (71-79) PII: S0021967302013584) Lienqueo M.E.; Mahn A.; Asenjo, JA Article JOURNAL OF CHROMATOGRAPHY A (2003)
Metabolic analysis of the synthesis of high levels of intracellular human SOD in Saccharomyces cerevisiae rhSOD 2060 411 SGA122 Gonzalez, R; Andrews, BA; Molitor, J Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2003)
Study of recombinant micro-organism populations characterized by their plasmid content per cell using a segregated model Shene, C; Andrews, BA Article ISI SCOPUS BIOPROCESS AND BIOSYSTEMS ENGINEERING (2003)
Kinetic model of BiP- and PDI-mediated protein folding and assembly Gonzalez, R; Andrews, BA Article ISI SCOPUS JOURNAL OF THEORETICAL BIOLOGY (2002)
Phase separation rates of aqueous two-phase systems: Correlation with system properties Mistry, SL; Andrews, BA; Merchuk, JC Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2002)
Refractive index, density, and viscosity in the NaNO 3 + H 2O + poly(ethylene glycol) system at various temperatures Galleguillos, H; Asenjo, JA; Andrews B. A. Article JOURNAL OF CHEMICAL AND ENGINEERING DATA (2002)
Incorporating process information in the optimal design of biotechnological plants Montagna, JM; Vecchietti, AR; Iribarren, OA Article ISI SCOPUS LATIN AMERICAN APPLIED RESEARCH (2001)
Influence of molecular weight of the polymer on the liquid-liquid equilibrium of the poly(ethylene glycol) + NaNo 3 + H 2O system at 298.15 K Asenjo, JA; Andrews B. A. Article JOURNAL OF CHEMICAL AND ENGINEERING DATA (2001)
Isolation, purification and preliminary characterization of cryophilic proteases of marine origin Salamanca, MH; Barría, C; Andrews, BA Article ISI BIOSEPARATION (2001)
Liquid-liquid and liquid-liquid-solid equilibrium in Na2CO3-PEG-H2O Taboada, ME; Andrews, BA Article ISI SCOPUS FLUID PHASE EQUILIBRIA (2001)
Metabolic control analysis of monoclonal antibody synthesis Gonzalez, R; Andrews, BA Article ISI SCOPUS BIOTECHNOLOGY PROGRESS (2001)
Overproduction, purification, and characterization of beta-1,3-glucanase type II in Escherichia coli Salazar, O.; Molitor, J Article ISI SCOPUS PROTEIN EXPRESSION AND PURIFICATION (2001)
Process performance models in the optimization of multiproduct protein production plants Montagna, JM; Vecchietti, AR; Iribarren, OA Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2001)
The role of process variables in the design of multiproduct batch protein production plants Montagna, JM; Vecchietti, AR; Iribarren, OA Article ISI SCOPUS LATIN AMERICAN APPLIED RESEARCH (2001)
Affinity gel electrophoresis as a predictive technique in the fractionation of transgenic sheep milk proteins by affinity aqueous two-phase partitioning Andrews, AT; Harris, DP; Wright, G Article ISI SCOPUS BIOTECHNOLOGY LETTERS (2000)
Drowning-out crystallisation of sodium sulphate using aqueous two-phase systems Taboada, ME; Graber, TA; Andrews, BA Article ISI SCOPUS Journal of Chromatography B (2000)
Effect of the growth conditions on the synthesis of a recombinant beta-1,4-endoglucanase in continuous and fed-batch culture Shene, C; Mir, N; Andrews, BA Article ISI SCOPUS ENZYME AND MICROBIAL TECHNOLOGY (2000)
Model for the partition of metal ions in aqueous two-phase systems Graber, TA; Andrews, BA Article ISI SCOPUS Journal of Chromatography B (2000)
Optimal design of protein production plants with time and size factor process models Montagna, JM; Vecchietti, AR; Iribarren, OA Article ISI SCOPUS BIOTECHNOLOGY PROGRESS (2000)
Strategies for the simultaneous optimization of the structure and the process variables of a protein production plant Montagna, JM; Vecchietti, AR; Iribarren, OA Article ISI SCOPUS COMPUTERS & CHEMICAL ENGINEERING (2000)
Use of expert systems for the synthesis of downstream protein processes Article ISI SCOPUS COMPUTERS & CHEMICAL ENGINEERING (2000)
XXI century: The century of biotechnology? Asenjo, JA Article ELECTRONIC JOURNAL OF BIOTECHNOLOGY (2000)
Cloning and expression of an Oerskovia xanthinteolytica ?-1,3-glucanase in Escherichia coli Salazar, O.; Molitor, J; Asenjo, JA Article BIOTECHNOLOGY LETTERS (1999)
Fedbatch fermentations of Bacillus subtilis ToC46 (pPFF1) for the synthesis of a recombinant ?-1,3-glucanase: Experimental study and modelling Shene, C; Andrews B. A.; Asenjo, JA Article ENZYME AND MICROBIAL TECHNOLOGY (1999)
Aqueous two-phase systems for protein separation studies on phase inversion Andrews B. A.; Asenjo, JA Article Journal of Chromatography B: Biomedical Applications (1998)
On the kinetics of phase separation in aqueous two-phase systems Andrews B. A.; Asenjo, JA Article Journal of Chromatography B: Biomedical Applications (1998)
Yeast cell permeabilizing ?-1,3-glucanases: A tool for the integration of downstream processes and metabolic engineering applications to yeast Ferrer, P; Asenjo, JA; Andrews B. A.; Diers I. Article BIOTECHNOLOGY AND BIOENGINEERING (1998)
A procedure for feasible and optimal operational strategies for control of CARE systems Rodrigues M.I.; Maugeri F.; Maciel-Filho R.; Asenjo, JA; Zaror C.A. Article JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (1997)
The application of aqueous two-phase systems to the purification of pharmaceutical proteins from transgenic sheep milk Harris D. P.; Wright, G; Pyle, D.L.; Asenjo, JA Article Bioseparation (1997)
An expert system for the selection and synthesis of multistep protein separation processes Lienqueo M.E.; Asenjo, JA; Leser E.W. Article COMPUTERS & CHEMICAL ENGINEERING (1996)
Conservative chemical modification of proteins to study the effects of a single protein property on partitioning in aqueous two-phase systems Franco T.T.; Asenjo, JA Article BIOTECHNOLOGY AND BIOENGINEERING (1996)
Correlations for the partition behavior of proteins in aqueous two-phase systems: Effect of overall protein concentration Andrews B. A.; Asenjo, JA Article BIOTECHNOLOGY AND BIOENGINEERING (1996)
Hydrophobic partitioning of proteins in aqueous two-phase systems Hachem F.; Andrews B. A.; Asenjo, JA Article ENZYME AND MICROBIAL TECHNOLOGY (1996)
Mathematical modeling of the synthesis of a cloned lytic ?-1,4-endoglucanase in Bacillus subtilis Shene, C; Andrews B. A.; Asenjo, JA; Mir, N Article ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (1996)
Mathematical modelling and computer simulation of aqueous two-phase continuous protein extraction Kaul, A; Asenjo, JA Article JOURNAL OF CHROMATOGRAPHY A (1996)
Molecular characterisation of a thermoactive ?-1,3-glucanase from Oerskovia xanthineolytica Parrado J.; Conejero-Lara F.; Kotik M.; Dobson C.M.; Escuredo P.R.; Asenjo, JA; Ponting C.P. Article Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology (1996)
Nucleotide sequence of a 13-1,3-glucanase Isoenzyme II(A) gene of Oerskovia xanthineolytica LL G109 (Cellulomonas cellulans) and initial characterization of the recombinant enzyme expressed in Bacillus subtilis Ferrer, P; Savva D.; Asenjo, JA; Halkier T.; Hedegaard L.; Diers I. Article JOURNAL OF BACTERIOLOGY (1996)
NUCLEOTIDE SEQUENCE OF A BETA-1,3-GLUCANASE ISOENZYME IIA GENE OF OERSKOVIA XANTHINEOLYTICA LLG109 (CELLULOMONAS CELLULANS) AND INITIAL CHARACTERIZATION OF THE RECOMBINANT ENZYME EXPRESSED IN BACILLUS SUBTILIS Savva, Demetris; Hedegaard, Lisbeth; Halkier, Torben; Ferrer, Pau; Diers, Ivan; Asenjo, Juan Article JOURNAL OF BACTERIOLOGY (1996)
Optimal control of batch processes involving simultaneous enzymatic and microbial reactions Asenjo, JA; Sun W.-H.; Spencer J.L. Article Bioprocess Engineering (1996)
Partitioning and purification of monoclonal antibodies in aqueous two-phase systems Andrews B. A.; Nielsen S.; Asenjo, JA Article Bioseparation (1996)
Protein partitioning equilibrium between the aqueous poly(ethylene glycol) and salt phases and the solid protein phase in poly(ethylene glycol)-salt two-phase systems Andrews B. A.; Asenjo, JA Article Journal of Chromatography B: Biomedical Applications (1996)
Reaction kinetics of the esterification of lauric acid in iso-octane using an immobilized biocatalyst Vazquez Lima F.; Pyle, D.L.; Asenjo, JA Article APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (1996)
Use of chemically modified proteins to study the effect of a single protein property on partitioning in aqueous two-phase systems: Effect of surface charge Franco T.T.; Asenjo, JA Article BIOTECHNOLOGY AND BIOENGINEERING (1996)
Use of chemically modified proteins to study the effect of a single protein property on partitioning in aqueous two-phase systems: Effect of surface hydrophobicity Franco T.T.; Asenjo, JA Article BIOTECHNOLOGY AND BIOENGINEERING (1996)
Mutagenesis Objective Search and Selectio Tool (MOSST) Olivera-Nappa, A.; Andrews B. A.; Asenjo, JA Article BMC BIOINFORMATICS
Non-Homogeneous Biofilm Modeling Applkied to Bioleahing Processes Olivera-Nappa, A.; Asenjo, JA; Picioreanu C. Article 1604-2004: SUPERNOVAE AS COSMOLOGICAL LIGHTHOUSES


Aqueous Two-Phase Systems Benavides, J; Asenjo, JA BookWhole SCOPUS Comprehensive Biotechnology, Second Edition (2011)


An Expert System for selection of protein purification processes: Experimental validation Lienqueo M.E.; Salgado, J. C.; Asenjo, JA ConferencePaper JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (1999)
Optimization and design considerations of two-phase continuous protein separation Huenupi, E; Gomez, A; Andrews B. A.; Asenjo, JA ConferencePaper JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (1999)
Implementation in an expert system of a selection rationale for purification processes for recombinant proteins Leser E.W.; Lienqueo M.E.; Asenjo, JA ConferencePaper ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (1996)
Molecular cloning of a lytic ?-1,3-glucanase gene from Oerskovia xanthineolytica LLG109. A ?-1,3-glucanase able to selectively permeabilize the yeast cell wall Ferrer, P; Hedegaard L.; Halkier T.; Diers I.; Savva D.; Asenjo, JA ConferencePaper ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (1996)


Aqueous two-phase systems for protein separation: A perspective Andrews, BA Review ISI SCOPUS Journal of Chromatography A (2011)
Challenges and trends in bioseparations Andrews, BA Review ISI JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2008)
Current insights on protein behaviour in hydrophobic interaction chromatography Mahn A.; Salgado JC Review ISI JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2007)
Enzymatic lysis of microbial cells Salazar, O. Review ISI BIOTECHNOLOGY LETTERS (2007)
Prediction of protein retention in hydrophobic interaction chromatography Mahn A. Review ISI SCOPUS BIOTECHNOLOGY ADVANCES (2005)

Carolina Shene

TITULAR PROFESSOR

CHEMICAL ENGINEERING

UNIVERSIDAD DE LA FRONTERA

TEMUCO, Chile

Maria Lienqueo

FULL PROFESSOR

OF CHEMICAL AND BIOTECHNOLOGY ENGINEERING

UNIVERSIDAD DE CHILE

Santiago, Chile

Maria Salazar

Profesora Asociada

Ingeniería Química Biotecnología y Materiales

UNIVERSIDAD DE CHILE, FAC. DE CIENCIAS FÍSICAS Y MATEMATICAS DEPTO. INGENIERÍA QUÍMICA

Santiago, Chile

Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

Claudio Zaror

Full professor

Chemical Engineering

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

Ziomara Gerdtzen

Profesora Asociada

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

Ivan Rapaport

Full Professor

Mathematical Engineering

Universidad de Chile

Santiago, Chile

ANDREA MAHN

Profesor Titular

Ingeniería Química

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

José Salgado

Associate Professor

Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

Maria Taboada

Profesor Titular

Facultad de Ingeniería

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Teófilo Graber

Académico. Profesor Titular

Ingeniería Química

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Carlos Conca

CO-FOUNDER ASSOCIATE RESEARCHER

CENTER FOR MATHEMATICAL MODELING

UNIVERSIDAD DE CHILE

Santiago, Chile

Axel Osses

Profesor Titular

Departamento de Ingeniería Matemática

Universidad de Chile

Santiago, Chile

Patricio Cumsille

Profesor Asociado

DEPARTAMENTO DE CIENCIAS BÁSICAS

UNIVERSIDAD DEL BÍO-BÍO

Chillán, Chile

Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

Alvaro Olivera

Principal Investigator and Assistant Professor

Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

Barbara Andrews

FULL PROFESSOR

CHEMICAL ENGINEERING AND BIOTECHNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

124

Juan Asenjo

Professor

CHEMICAL AND BIOTECHNOLOGY ENGINEERING

University of Chile

SANTIAGO, Chile

Alejandro Buschmann

FULL PROFESSOR

UNIVERSIDAD DE LOS LAGOS

PUERTO MONTT, Chile

Julio Aracena

Full Professor

Ingeniería Martemática

Universidad de Concepción

Concepción, Chile

Eric Goles

Full Professor

Facultad de Ingeniería y Ciencias

Universidad Adolfo Ibáñez

Santiago, Chile

Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

Pablo Moisset de Espanés

Encargado centro de computos drado de ecologia integrativa

Universidad Mayor de Chile

Santiago, Chile

loreto parra

Assitant Professor

Chemical and Bioprocesses Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Giannina Espina

Santiago, Chile

Alicia Lucero

Responsable de Transferencia Tecnológica

Fundación Leitat Chile

Santiago, Chile

Angela Cintolesi Makuc

Postdoctorado

Centro de Modelamiento Matemático

Universidad de Chile

Santiago, Chile

Vida Rodríguez

Investigadora Postdoctoral

Universidad de Chile

Santiago, Chile

Gabriela Sandoval

Jefe de carrera

Departamento de Ingeniería Química

Universidad Tecnológica Metropolitana

Santiago, Chile

Daniela Vaisman

Gerente General

Botanitec

San Antonio, Chile

Ana Quiroga

Senior scientist

Early oncology

AstraZeneca

Cambridge, Reino Unido

Jean Castro

Curador

Banco de Recursos Genéticos Microbiano

Instituto de Investigaciones Agropecuarias

Chillán, Chile

Valeria Razmilic

Investigadora postdoctoral

Centro de Biotecnología y Bioingeniería

Universidad de Chile

Santiago, Chile

Camila Orellana

Profesor Asistente

Ingeniería Química y Bioprocesos

Pontificia Universidad Católica de Chile

Santiago, Chile

FRANCESCA MERCADO

Gerente de Calidad y Sostenibilidad

Operaciones

Wurth Group

Santiago, Chile

Juan Alfonso Asenjo De Leuze de Lancizolle

Líneas de Investigación

Educación

BIOCHEMICAL ENGINEERING, UNIVERSITY COLLEGE LONDON. Reino Unido, 1978

FOOD ENGINEERING, UNIVERSITY OF LEEDS. Reino Unido, 1977

INGENIERO CIVIL QUIMICO, UNIVERSIDAD DE CHILE. Chile, 1975

Experiencia Académica

PROFESSOR Full Time

ASSISTANT PROFESSOR Full Time

ASSOCIATE PROFESSOR Full Time

READER OF BIOCHEMICAL ENGINEERING Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

NATIONAL SCIENCE PRIZE

ELECTED MEMBER OF CHILEAN ACADEMY OF SCIENCES

PRESIDENCIAL CHAIR IN SCIENCES

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