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Camila Antonia Orellana Montecino

Profesor Asistente

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Bioengineering and biotechnology, biopharmaceutical production (vaccines, monoclonal antibodies and antibiotics), optimization of cell lines, media and production processes, metabolic engineering, fermentation, systems biology, omics

Educación

  •  Biotecnology, UNIVERSITY OF QUEENSLAND. Australia, 2016
  •  Chemical Engineering, UNIVERSIDAD DE CHILE. Chile, 2009
  •  Civil Engineer in Biotechnology, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

  •   Assistant Professor Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Engineering

    Santiago, Chile

    2020 - A la fecha

  •   Postdoctoral Research Fellow Full Time

    UNIVERSITY OF QUEENSLAND

    Brisbane, Australia

    2016 - 2019

Experiencia Profesional

  •   Analyst of technological businesses and project formulation Full Time

    Dictuc S.A.

    Santiago, Chile

    2009 - 2010

  •   ASIS Program (Tasty, Safe and Healthy Foods) executive manager Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2010 - 2011

  •   Casual Professional Staff Part Time

    The University of Queensland

    Brisbane, Australia

    2014 - 2016

Formación de Capital Humano


DIRECTED THESES
PhD:
Nicolas E Zaragoza. (2020). Thesis: “Characterising quorum sensing regulation in Clostridium tetani E88 fermentation”. The University of Queensland. Australia. Co-supervisor.
Undergraduate:
B. Eng (Hons.) Nicholas Cowie. (2017). Thesis: “Increasing TeNT Production in C. tetani Using Machine Learning”. The University of Queensland. Australia. Co-supervisor.

LAB FORMATION
Kanupriya Tiwari, Aude Durand, Nicolás Zaraoza, Nicholas Cowie, Craig Barry and Rosemary Gillane.


Difusión y Transferencia


CONFERENCE PRESENTATIONS & POSTERS
1. C.A. Orellana, N. Zaragoza, C. Licona-Cassani, G. Moonen, G. Moutafis, J. Power, L.K. Nielsen, E. Marcellin. Improving tetanus toxoid vaccine production. BLiSS. Brisbane, Australia. 24 November 2017. Poster.
2. C.A. Orellana, N. Zaragoza, C. Licona-Cassani, G. Moonen, G. Moutafis, J. Power, L.K. Nielsen, E. Marcellin. Improving tetanus toxoid vaccine production. International Conference in BioNano Innovation. Brisbane, Australia. 24-27 September 2017. Poster.
3. C.A. Orellana, E. Marcellin., T. Munro, P.P. Gray, L.K. Nielsen. Multi-omics approach for comparative studies of monoclonal antibody producing CHO cells. 24th European Society for Animal Cell Technology (ESACT) meeting. Barcelona, Spain. 31 May – 3 June, 2015. Oral presentation.
4. C.A. Orellana, T. Munro, P.P Gray, E. Marcellin, L.K. Nielsen. A systems biology approach to improve host cells for biopharmaceutical production. 3rd International NanoBio Conference. Brisbane, Australia. 7-10 July, 2014. Oral presentation.
5. C.A. Orellana, T. Munro, P.P Gray, E. Marcellin, L.K. Nielsen. A systems biology approach to improve host cells for biopharmaceutical production. Cell Culture Engineering XIV. Quebec City, Canada. 4-9 May, 2014. Poster and oral presentation in workshop “Applications of –omics technology”.
6. C.A. Orellana, P.P. Gray, L.K. Nielsen, T. Munro. A systems biology approach to improve host cells for biopharmaceutical production. The Bioprocessing Network 2013 Conference. Gold Coast, Australia. 22-24 October, 2013. Oral presentation.
7. C.A. Orellana, M. Song, P.P. Gray, L.K. Nielsen, T. Munro. Improving host cells for biopharmaceutical production. 1st International Conference on BioNano Innovation. Brisbane, Australia. 19-20 July, 2012. Poster.
8. J. Asenjo, C.A. Orellana, B. Andrews. Mathematical modeling of a protein mixture in chromatography applied to high protein concentrations and optimal selection of operating conditions. 15th International Conference on Biopartitioning and Purification. Uxbridge, UK. 14-19 June, 2009. Oral presentation by J. Asenjo.
9. J. Asenjo, C.A. Orellana, B. Andrews. Mathematical modeling of a protein mixture in chromatography applied to high protein concentrations and optimal selection of operating conditions. 6th HIC/RPC Bioseparation Conference: Advancements, Applications and Theory in Downstream Processing. Napa, CA. 15-19 Mach, 2009. Oral presentation by J. Asenjo.

CONFERENCE ORGANIZATION
1st Meeting of Chilean Scientists in Brisbane, 31 July 2015 at the Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, Australia.
The aim was to strengthen ties between the Chilean and Australian scientific communities. The invitation was open to all Chilean researchers residing in Australia as well as important Australian and Chilean researchers from a broad scientific background, especially those from Biological Sciences, Veterinary Sciences, Medical Sciences, Chemistry, Biotechnology and Engineering.


Premios y Distinciones

  •   Scholarship “Becas Chile” for an overseas PhD

    CONICYT, Chilean government

    Chile, 2010

    Scholarship for PhD studies abroad, aimed at excellent Chilean or foreign students with permanent residence in Chile, to start or continue studies, in programs related to the areas established as of priority interest for the country; in institutions of excellence abroad for a maximum term of four years.

  •   Award Best Biotechnological Engineer, promotion 2009

    COLEGIO DE INGENIEROS DE CHILE A.G.

    Chile, 2010

    Every year the College of Engineers of Chile (Colegio de Ingenieros de Chile) awards a Distinction ("Premio a los mejores Titulados") to the best engineers graduated from the latest class of the Universities and Polytechnic Academies recognized by the College. This Distinction is awarded to those engineers designated by the respective Universities, in recognition of academic performance and their leadership and participation conditions.

  •   Young Investigator Award

    The Bioprocessing Network Conference

    Australia, 2013

    Award to the best student oral presentation at The BioProcessing Network Conference 2013. This anual Conference gathers together researchers, manufacturers, suppliers, and others with an active interest in bioprocessing as applied to a broad range of industrial and academic research areas.

  •   Fee scholarship for the Master

    UNIVERSIDAD DE CHILE

    Chile, 2007

    Fee Scholarship for the Master of Science in Engineering given by the Faculty of Physics and Mathematics, Universidad de Chile.

  •   Scholarship to attend an EMBO practical course

    EMBO

    España, 2017

    Scholarship to attend the EMBO practical course “Targeted proteomics: Experimental design and data analysis”. Barcelona, Spain, 12-17 November.


 

Article (12)

'Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells
Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production
Time-course transcriptomics reveals that amino acids catabolism plays a key role in toxinogenesis and morphology in Clostridium tetani
Revisiting the Evolution and Taxonomy of Clostridia, a Phylogenomic Update
Vaccine Production to Protect Animals Against Pathogenic Clostridia
RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells
Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cells
A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism
Recon 2.2: from reconstruction to model of human metabolism
Reconstruction of Setaria italica: A Systems Biology Approach for Integrating Tissue-Specific Omics and Pathway Analysis of Bioenergy Grasses
High-Antibody-Producing Chinese Hamster Ovary Cells Up-Regulate Intracellular Protein Transport and Glutathione Synthesis
Mathematical Modeling of Elution Curves for a Protein Mixture in Ion Exchange Chromatography Applied to High Protein Concentration

Proyecto (2)

Developing death-resistant CHO cell lines as a platform for biopharmaceutical production
Redefining Bioproduction: Customized CHO Cell Platforms for Streamlined Continuous Manufacturing
14
Camila Orellana

Profesor Asistente

Ingeniería Química y Bioprocesos

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Carolina Shene

TITULAR PROFESSOR

CHEMICAL ENGINEERING

UNIVERSIDAD DE LA FRONTERA

TEMUCO, Chile

1
Nicolas Loira

CTO AlicantoLabs

Escuela de Negocios

Universidad Adolfo Ibáñez

Santiago, Chile

1
Juan Asenjo

Professor

CHEMICAL AND BIOTECHNOLOGY ENGINEERING

University of Chile

SANTIAGO, Chile

1
Ziomara Gerdtzen

Profesora Asociada

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile