Man

Alvaro María Olivera Nappa

Principal Investigator and Assistant Professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Biotechnology & Applied Microbiology; Biochemistry & Molecular Biology; Structural Biology; Protein Engineering; Enzymology and Protein Science; Mathematical & Computational Biology; Bioinformatics; Synthetic Biology; Applied Statistics & Probability

Educación

  •  Engineering Sciences, Chemical Processes, UNIVERSIDAD DE CHILE. Chile, 1995
  •  CHEMICAL ENGINEER, UNIVERSIDAD DE CHILE. Chile, 2003
  •  CHEMICAL ENGINEER, BIOTECHNOLOGY, UNIVERSIDAD DE CHILE. Chile, 2005

Experiencia Académica

  •   Faculty Member and Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Physical and Mathematical Sciences

    Santiago, Chile

    2013 - A la fecha

  •   Post-Doctoral Researcher Full Time

    UNIVERSIDAD DE CHILE

    Physical and Mathematical Sciences

    Santiago, Chile

    2007 - 2011

  •   Post-Doctoral Researcher Full Time

    UNIVERSIDAD DE CHILE

    Physical and Mathematical Sciences

    Santiago, Chile

    2005 - 2006

  •   Adjunct Professor Part Time

    UNIVERSIDAD DE CHILE

    Physical and Mathematical Sciences

    Santiago, Chile

    2008 - 2011

  •   Visiting Post-Doctoral Scholar Full Time

    DELFT UNIVERSITY OF TECHNOLOGY

    Delft, Holanda

    2007 - 2007

  •   Visiting Post-Doctoral Scholar Full Time

    UNIVERSITY OF CAMBRIDGE

    Cambridge, Reino Unido

    2012 - 2012

Experiencia Profesional

  •   Founder & Honorary R&D Director Other

    Lucien Biotechnologies

    Santiago, Chile

    2006 - A la fecha

  •   Honorary R&D Director Other

    Cosmetofood S.A.

    Santiago, Chile

    2009 - 2011

  •   External Advisor Other

    Bayas del Sur S.A.

    Purranque, Chile

    2011 - 2011

  •   External Advisor Other

    BAL Chile S.A.

    Puerto Montt, Chile

    2013 - A la fecha

  •   External Expert Other

    PricewaterhouseCoopers

    Santiago, Chile

    2008 - 2009

Formación de Capital Humano


Postgraduate student guide in the last 5 years
Carlos Gómez, “New evolutive operation-based methodology for in silico protein engineering”, Doctorado en Ingeniería Química, Universidad de Chile. 2018. (Co-Guía).
Javiera Gómez, “Synthetic biology in Escherichia coli BAL1611 to optimize ethanol production from alginate and mannitol from Macrocystis pyrifera”, MSc in Chemical engineering, University of Chile. 2019. (Advisor).
Pablo Troncoso, “The role of the biotechnology industry in the sophistication and diversification of the Chilean productive matrix: difficulties and proposals for development”, MSc in Chemical engineering, University of Chile. 2019. (Co-Advisor).
Juan Pablo Biron, "Evaluation of the proteolytic capacity of Lactobacilli isolated from sourdough on gliadin-derived proline-rich peptides", MSc in Chemical engineering, University of Chile. 2020. (Advisor).
Diego Narváez, "Implementation and development of methodologies for characterization of cellular composition as an input for formulating empirical mathematical models", MSc in Chemical engineering, University of Chile. 2020. (Co-Advisor).
Karen Oróstica, "Implementation of cancer classification models based on mutational and clinical data", PhD in Chemical Engineering and Biotechnology, University of Chile. 2021. (Advisor).
David Medina, “Applications of Machine Learning and Data Mining in protein engineering design and implementation of new strategies for the study of mutations”, PhD in Chemical Engineering and Biotechnology, University of Chile. 2022. (Advisor).
Benjamín Armijo, “Implementation and validation of a computational system and a purification process for the improvement of the MachinePep system”, MSc in Chemical Engineering, University of Chile. 2022. (Advisor).
Juan Amado, “Protein engineering for the rational design of Anti-HIV peptides and improvement of the peptide production platform for its recombinant production”, PhD in Chemical Engineering and Biotechnology, University of Chile. 2022. (Advisor).


Difusión y Transferencia


Activities in the last 5 years.

Lecturer in extension courses:
Workshop of Multimedia Education in Sciences for high-school science teachers, organized by the Institute for Cell Dynamics and Biotechnology and the Centre for Biotechnology and Bioengineering, Santiago, Chile.

Invited speaker:
Motivation Talks on Science and Biotechnology for High-School Students, organized by the Institute for Cell Dynamics and Biotechnology, Santiago, Chile.
“Chemistry of life and patent rights”, Intellectual Property Court – Seminar for attorneys and judges specialized in intellectual property.

Media coverage:
TV news show 24 horas, “CeBiB research on the COVID-19 pandemics in Chile”, Televisión Nacional, Chile.
UdeC Radio note, “Study shows that gamma has been the most transmissible variant in Chile”, Chile.
CNN Chile TV and press note, “Gamma has been the most transmissible variant in Chile, according to a study of the Chilean Public Health Institute and University of Chile”, Chile.
Qué Pasa magazine article, “Study shows that gamma has been the most transmissible variant in Chile”, Chile.
FCFM magazine article, “Why ammonium nitrate would be responsible for the huge Beirut explosion?”, Chile.
Teletrece TV, central news show, live expert interview about the explosion of an ammonium nitrate deposit explosion at Beirut's harbor, Chile.
University of Chile news article, “CeBiB's research: mismatch between PCR diagnostic date, symptomatology and COVID-19 incubation time reports influenced decisions to apply restrictive measures”, Chile.
El Mercurio newspaper article, “Mismatch between new case data reports would have had an impact on the increase in COVID-19 contagion”, Chile.


Premios y Distinciones

  •   United Engineering Foundation Young Scientist Fellowship

    United Engineering Foundation

    Estados Unidos, 2001

    Travel Scholarship and Award to present research results at the XVI Enzyme Engineering Conference, Potsdam, Germany.

  •   IUBMB-Sigma Aldrich Corporation Scholarship

    IUBMB / Sigma-Aldrich Corp.

    Chile, 2005

    Travel Scholarship and Award to present research results at the 30th Congress of the FEBS and the 9th IUBMB Conference, Budapest, Hungary.

  •   Platinum First Prize

    World's Best Technologies Showcase

    Estados Unidos, 2006

    First place in the World's Best Technologies showcase and contest, for the development of technologies to modulate flavonoid synthesis in vivo in plants.

  •   100 Young Chilean Leaders

    DIARIO EL MERCURIO

    Chile, 2006

    Recognized as one of the 100 Young Chilean Leaders for the development of technologies to modulate flavonoid synthesis in vivo in plants, and the awards received in Chile and abroad for this motive.

  •   Young Scientist Member of the Lindau Nobel Laureate Meetings

    Lindau Nobel Laureate Meetings Council

    Alemania, 2009

    Selected as a Chilean young scientist representative in the 59th Lindau Nobel Laureate Meeting devoted to chemistry.

  •   Member of the Frontier Science Program

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2011

    Recognition to the excellency and potential of young scientists in different scientific disciplines.

  •   IAP Young Scientist Nominee 2012

    Interacademy Panel (IAP)

    Italia, 2012

    Selected by the Interacademy Panel of Academies of Sciences as a Chilean young scientist representative for the World Economic Forum Annual Meeting of the New Champions in Tianjin, China.

  •   Scientific Member of the World Economic Forum

    World Economic Forum

    China, 2012

    Permanent member of the scientific panel of the World Economic Forum.

  •   First Place of the Avonni Innovation Contest

    Innovation Forum

    Chile, 2012

    Cosmetofruit S.A.'s first place in the food category. Responsible for the development of the polyphenolic nutricosmetic formulations of Cosmetofruit.

  •   Distinguished Professor in University Research Activities

    UNIVERSIDAD DE CHILE

    Chile, 2021

    Honor bestowed by the Vicechancellor's Office of Research and Development, for the most productive academic researchers in the University of Chile.

  •   Distinguished Professor in University Research Activities

    UNIVERSIDAD DE CHILE

    Chile, 2020

    Honor bestowed by the Vicechancellor's Office of Research and Development, for the most productive academic researchers in the University of Chile.


 

Article (42)

Model-based assessment of sampling protocols for infectious disease genomic surveillance
Generalized Property-Based Encoders and Digital Signal Processing Facilitate Predictive Tasks in Protein Engineering
New year, new SARS-CoV-2 variant: Resolutions on genomic surveillance protocols to face Omicron
Patient-Wise Methodology to Assess Glycemic Health Status: Applications to Quantify the Efficacy and Physiological Targets of Polyphenols on Glycemic Control
Rethinking COVID-19 vaccine allocation: it is time to care about our neighbours
Total mutational load and clinical features as predictors of the metastatic status in lung adenocarcinoma and squamous cell carcinoma patients
BEST: A Shiny/R web-based application to easily retrieve cross-related enzyme functional parameters and information from BRENDA
Enhanced Cellular Uptake of H-Chain Human Ferritin Containing Gold Nanoparticles
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike's Dynamics
Novel Symbiotic Genome-Scale Model Reveals Wolbachia's Arboviral Pathogen Blocking Mechanism in Aedes aegypti
On the heterogeneous spread of COVID-19 in Chile
Peptipedia: a user-friendly web application and a comprehensive database for peptide research supported by Machine Learning approach
Relaxing restrictions at the pace of vaccination increases freedom and guards against further COVID-19 waves
A multi -group SEIRA model for the spread of COVID-19 among heterogeneous populations
A new statistically-based methodology for variability assessment of rheological parameters in mineral processing
A Novel Synthetic Model of the Glucose-Insulin System for Patient-Wise Inference of Physiological Parameters From Small-Size OGTT Data
Country-Wise Forecast Model for the Effective Reproduction NumberR(t)of Coronavirus Disease
Development of Supervised Learning Predictive Models for Highly Non-linear Biological, Biomedical, and General Datasets
DMAKit: A user-friendly web platform for bringing state-of-the-art data analysis techniques to non-specific users
Real-Time Estimation of R-t for Supporting Public-Health Policies Against COVID-19
Silver nanoparticle synthesis in human ferritin by photochemical reduction
Statistically-based methodology for revealing real contagion trends and correcting delay-induced errors in the assessment of COVID-19 pandemic
Structural bases that underline Trypanosoma cruzi calreticulin proinfective, antiangiogenic and antitumor properties
A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection
Cell cycle and protein complex dynamics in discovering signaling pathways
An optimized low-cost protocol for standardized production of iron-free apoferritin nanocages with high protein recovery and suitable conformation for nanotechnological applications
Protein complex prediction via dense subgraphs and false positive analysis
Delphinidin-Rich Maqui Berry Extract (Delphinol®) Lowers Fasting and Postprandial Glycemia and Insulinemia in Prediabetic Individuals during Oral Glucose Tolerance Tests
Scaling up bioethanol production from the farmed brown macroalga Macrocystis pyrifera in Chile
Analyzing redox balance in a synthetic yeast platform to improve utilization of brown macroalgae as feedstock
Iron-induced reactive oxygen species mediate transporter DMT1 endocytosis and iron uptake in intestinal epithelial cells
An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma
Cold Adaptation, Ca2+ Dependency and Autolytic Stability Are Related Features in a Highly Active Cold-Adapted Trypsin Resistant to Autoproteolysis Engineered for Biotechnological Applications
Thyroid dyshormonogenesis is mainly caused by TPO mutations in consanguineous community
Purification of transthyretin as nutritional biomarker of selenium status
A kinetic model for the storage of iron in ferritin
Mutagenesis Objective Search and Selection Tool (MOSST): an algorithm to predict structure-function related mutations in proteins
Mathematical modeling of the dynamic storage of iron in ferritin
Non-Homogeneous Biofilm Modeling Applied to Bioleaching Processes
Multilevel interactions in Systems Biology: from DNA to proteins to metabolism and back in bacteria, yeasts and plants
A mixed mechanistic-electrostatic model to explain pH dependence of glycosyl hydrolase enzyme activity
Effect of electrostatic energy on partitioning of proteins in aqueous two-phase systems

Abstract (1)

Characterization, cloning, recombinant expression and protein engineering of a cryophilic protease of marine origin and its engineered mutants

BookWhole (1)

Production of bioethanol from brown algae

Proyecto (10)

FERRITEAM=> Diseño y Aplicaciones de BioNanoMateriales en Base a Ferritina
MOSTICAW - MOdeling the Spread and (opTImal) Control of Arboviroses by Wolbachia
Centre for Biotechnology and Bioengineering (CeBiB)
Integrative bioinformatic tools to accurately predict the effects of mutations in cancer-related proteins and to guide the design of rational protein engineering strategies
A systems biology approach for studying and understanding cellular processes involved in the regulation of intestinal iron absorption.
Producción de ingrediente funcional estandarizado y clínicamente probado para control de glicemia en diabéticos
Desarrollo de formulaciones prototipo para modular la síntesis de antocianinas y flavonoides en frutas=> mejoramiento de la calidad visual, contenido nutricional, competitividad y valor comercial de la fruta de exportación
Efecto de la suplementación dietaria con selenio orgánico sobre el proteoma sanguíneo=> identificación de nuevos bioindicadores del status metabólico del selenio.
Investigación, desarrollo y producción de proteasas y lipasas criofílicas comerciales de fuentes marinas
Síntesis y sobreproducción de una glucanasa lítica recombinante=> modelamiento matemático, purificación y uso.
41
Alvaro Olivera

Principal Investigator and Assistant Professor

Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

10
David Medina

Assistant Professor

Departamento de Ingeniería en Computación

Universidad de Magallanes

Punta Arenas, Chile

8
Sebastián Contreras

Doctoral Researcher

Neural Systems Theory

Max Planck Institute for Dynamics and Self-Organization

Göttingen, Alemania

7
Juan Asenjo

Professor

CHEMICAL AND BIOTECHNOLOGY ENGINEERING

University of Chile

SANTIAGO, Chile

6
Carlos Conca

CO-FOUNDER ASSOCIATE RESEARCHER

CENTER FOR MATHEMATICAL MODELING

UNIVERSIDAD DE CHILE

Santiago, Chile

6
Barbara Andrews

FULL PROFESSOR

CHEMICAL ENGINEERING AND BIOTECHNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

4
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

4
Ziomara Gerdtzen

Profesora Asociada

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

3
José Salgado

Associate Professor

Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Karen Oróstica

Vigilancia genómica

Genética Molecular

Universidad de Tal

Santiago, Chile

3
Anamaria Daza

Investigadora

Centre for Biotechnology and Bioengineering

Santiago, Chile

2
Natalia Jimenez

Profesora Asistente

Departamento de Ingeniería Biológica y Médica, Departamento de Ingeniería Química y Bioprocesos

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Maria Lienqueo

FULL PROFESSOR

OF CHEMICAL AND BIOTECHNOLOGY ENGINEERING

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Monica Soler

Associate Professor

Chemical Engineering, Biotechnology and Materials

University of Chile

Santiago, Chile

2
Nyna Llanovarced

Tesista de doctorado

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

2
Marcelo Navarrete

Profesor Titular

Medicina

Universidad de Magallanes

Punta Arenas, Chile

2
Maria Salazar

Profesora Asociada

Ingeniería Química Biotecnología y Materiales

UNIVERSIDAD DE CHILE, FAC. DE CIENCIAS FÍSICAS Y MATEMATICAS DEPTO. INGENIERÍA QUÍMICA

Santiago, Chile

2
Cecilia Hernández

Profesor Asistente

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
Alejandro Buschmann

FULL PROFESSOR

UNIVERSIDAD DE LOS LAGOS

PUERTO MONTT, Chile

1
Brian Townley

Associate Professor

Geology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Jaime Peña

Coordinador de Prácticas y Titulación

Universidad Autónoma de Chile

Temuco, Chile

1
Carolina Shene

TITULAR PROFESSOR

CHEMICAL ENGINEERING

UNIVERSIDAD DE LA FRONTERA

TEMUCO, Chile

1
Carolina Camus

Investigador

Centro i-mar

Universidad de Los Lagos

Puerto Montt, Chile

1
Roberto Uribe

Académico

Ingeniería en Computación

Universidad de Magallanes

Punta Arenas, Chile

1
Claudia Saavedra

Full Professor

Departmento de Ciencias de la Vida

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
CAROLINA VALCK

ASSISTANT PROFESSOR

IMMUNOLOGY DISCIPLINARY PROGRAM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Christian Ihle

Profesor Asociado

Ingeniería de Minas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
ANDREA MAHN

Profesor Titular

Ingeniería Química

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Simon Guerrero

Investigador

Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK

Universidad SEK

Santiago, Chile

1
Diego Seco

Associate Professor

DIICC

Universidad de Concepción

Concepción, Chile