Man

Anamaria Constanza Daza Sanchez

Investigadora

Centre for Biotechnology and Bioengineering

Santiago, Chile

Líneas de Investigación


Terapia Génica y Celular, Cultivo Celular, Stem cells, Producción y purificación de virus, Biología molecular, Expresión y purificaciób_: de proteínas recombinantes, Extremofilos,

Educación

  •  Doctora en Cs de la Ingeniería, mención Ingeniería Química y Biotecnología, UNIVERSIDAD DE CHILE. Chile, 2017
  •  Magíster en Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2011
  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

  •   Profesor Auxiliar Other

    UNIVERSIDAD DE CHILE

    Ciencias Físicas y Matemáticas

    Santiago, Chile

    2011 - 2014

  •   Profesor de Cátedra - Aplicaciones de la Biología en Ciencias e Ingeniería Part Time

    UNIVERSIDAD DE CHILE

    Ciencias Físicas y Matemáticas

    Chile

    2020 - A la fecha

  •   Profesora Participante - Unidad de Investigación I Part Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Chile

    2023 - A la fecha

  •   Profesor de Cátedra-Enzimología y Estructura de Proteínas Part Time

    UNIVERSIDAD DE CHILE

    Ciencias Físicas y Matemáticas

    Santiago, Chile

    2025 - A la fecha

Experiencia Profesional

  •   Investigadora Full Time

    Centre for Biotechnology and Bioengineering

    Santiago, Chile

    2017 - A la fecha

  •   Interna Other

    Gene Therapy Center, University of North Carolina at Chapel Hill

    North Carolina, Estados Unidos

    2015 - 2016

  •   Investigador Postdoctoral Full Time

    ICDB

    Chile

    2018 - 2022

  •   Investigadora Part Time

    ICDB-Instituto de Dinámica Celular y Biotecnoogía

    Chile

    2023 - A la fecha

  •   Youg Researcher Part Time

    Centre for Biotechnology and Bioengineering

    Santiago, Chile

    2023 - A la fecha

Formación de Capital Humano


MENTORING STUDENTS

Name: Paulina Soto Farias
Degree Granted: Undergraduate and Master’s Degree
Program: Master’s in engineering sciences, with a specialization in Chemical and Civil Engineering in
Biotechnology and Civil Engineering in Biotechnology
Thesis title: Adaptation of Melanoma Cell Lines to Suspension Cultures Using Microcarriers for the Production of Immunogenic Lysates for Application in Human Melanoma Vaccines
Period: March 2024 - Present
Institution: Universidad de Chile and Oncobiomed.
Role: Co-advisor

Name: Lilier Simons
Degree Granted: Undergraduate and Master’s Degree
Program: Master’s in engineering sciences, with a specialization in Chemical and Civil Engineering in Biotechnology and Civil Engineering in Biotechnology
Thesis title: To be defined
Period: March 2024 - Present
Institution: Universidad de Chile
Role: Co-advisor

Name: Agustín Avilés
Degree Granted: Undergraduate Degree
Program: Civil Engineering in Biotechnology
Thesis title: Design and Prototyping of a Cultivation and Separation System for Mesenchymal Cells
Period: December 2024 - Present
Institution: Universidad de Chile
Role: Co-advisor

Name: Vicente Mérida
Degree Granted: Undergraduate and Master’s Degree
Program: Master’s in engineering sciences, with a specialization in Chemical and Civil Engineering in Biotechnology and Civil Engineering in Biotechnology
Thesis title: Design, Scaling, and 3D Printing of a Mesenchymal Stem Cell Separation System for Suspension Cultures
Period: March 2024 – Present
Institution: Universidad de Chile
Role: Co-advisor

Name: Pilar Vera
Degree Granted: Undergraduate and Master’s Degree
Program: Civil Engineering in Biotechnology and Master’s in engineering sciences, with a specialization in Chemical and Civil Engineering in Biotechnology and Civil Engineering in Biotechnology
Thesis title: Optimization of Suspension Culture in Xeno-Free Conditions for Wharton’s Jelly Stem Cells
Period: March 2024 - Present
Institution: Universidad de Chile
Role: Co-advisor

Name: Felipe Matus
Degree Granted: Undergraduate and Master’s Degree
Program: Master’s in engineering sciences, with a specialization in Chemical and Civil Engineering in Biotechnology and Civil Engineering in Biotechnology
Thesis title: Optimization of Stem Cell Harvesting in Suspension Cultures
Period: August 2022 – March 2025
Institution: Universidad de Chile
Role: Co-advisor

Name: Temistocles Molina
Degree Granted: Civil Engineering in Biotechnology, 2023
Program: Civil Engineering in Biotechnology
Thesis title: Optimization of Cultivation Conditions and Improvement of Proliferation of Mesenchymal Stem Cells Derived from Human Adipose Tissue
Period: January 2022 - January 2023
Institution: Universidad de Chile
Role: Co-advisor

Name: Jorge Rojas
Degree Granted: Civil Engineering in Biotechnology, 2021
Program: Civil Engineering in Biotechnology
Thesis title: Isolation, Cultivation, and Differentiation of Adipose-Derived and Wharton’s Jelly Stem Cells for Use in Cell Therapy for Premature Ovarian Failure
Period: January - August 2021
Institution: Universidad de Chile
Role: Thesis committee member

Name: Lorna León
Degree Granted: Civil Engineering in Biotechnology, 2019
Program: Civil Engineering in Biotechnology
Thesis title: Suspension Culture of Mesenchymal Cells Derived from Adipose Tissue for Cell Therapy
Period: August 2018 - August 2019
Institution: Universidad de Chile
Role: Lab mentor and supervisor


Difusión y Transferencia


2017-2020: Participante en el programa “Conoce la Ciencia”, proyecto de divulgación científica para estudiantes de Enseñanza media en CeBiB, Universidad de Chile.

Course Organization: "Animal Cell Technology: Development and Production of Biotherapeutics" (TCA), November 2024, Santiago, Chile.

Speaker at the Course: "Animal Cell Technology: Development and Production of Biotherapeutics" (TCA) – Presentation: "Expansion of Human MSCs in High-Density Suspension Cultures for Therapeutic Applications", November 2024, Chile.


Premios y Distinciones

  •   Nominada para asistir 70th Lindau Nobel Laureate Meeting

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2020

    Nominada por la Academia Chilena de Ciencias para representar a Chile en la prestigiosa conferencia "70th Lindau Nobel Laureate Meeting". La Nominación fue aprobada por el comité de Lindau Nobel Laureate Meeting, por lo que fui seleccionada para asistir a este encuentro con premios Nobeles. Debido a la pandemia, la participación presencial en esta conferencia fue pospuesta. Sin embargo se realizó una conferencia virtual, de la cuál pude participar.

  •   2015 CONICYT beca para pasantía Doctoral

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2015

    Beca para pasantía Doctoral, University of North Carolina at Chapel Hill, Gene Therapy Center

  •   CONICYT beca para estudios de Doctorado Nacional

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    2012 CONICYT beca para estudios de Doctorado Nacional, programa Doctorado en Ciencias de la Ingeniería mención Química y Biotecnología, Universidad de Chile

  •   "72th Lindau Nobel Laureate Meeting"

    Council for the Lindau Nobel Laureate Meetings/ Foundation Lindau Nobel Laureate Meetings

    Alemania, 2023

    Patrocinio para participar en "72th Lindau Nobel Laureate Meeting" The 72nd Lindau Nobel Laureate Meeting was dedicated to Physiology and Medicine. Young Scientists who had been selected from this field for #LINO70 and took part in the digital meeting were invited to participate on site from 25–30 June 2023. Additionally, Young Scientists selected in the nomination and application process 2022-23 also travelled to Lindau.

  •   Mejor egresada Bioquímica

    UNIVERSIDAD DE CHILE

    Chile, 2011

    Mejor egresada de la generación pregrado Bioquímica

  •   Scholarship to attend to Cellular Bioprocessing Technology Short Course

    UNIVERSITY OF MINNESOTA

    Estados Unidos, 2021

    Bioprocess design and operations: engineering principles in action Expert perspectives on emerging technological trends for biologics Efficient packaging of knowledge, succinct summary of how-to's, and effective passing-on of valuable experiences Lessons learned and success stories from the past two decades


 

Article (12)

In Vitro Bioaccessibility of Edible Seaweed Proteins from the Chilean Coast and Proteins from the Novel Seaweed-Derived Mycoprotein
Early mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants in Chile
Peptide-based drug discovery through artificial intelligence: Towards an autonomous design of therapeutic peptides
Peptipedia v2.0: a peptide sequence database and user-friendly web platform. A major update
Model-based assessment of sampling protocols for infectious disease genomic surveillance
New year, new SARS-CoV-2 variant: Resolutions on genomic surveillance protocols to face Omicron
BEST: A Shiny/R web-based application to easily retrieve cross-related enzyme functional parameters and information from BRENDA
On the heterogeneous spread of COVID-19 in Chile
Peptipedia: a user-friendly web application and a comprehensive database for peptide research supported by Machine Learning approach
Heterologous expression and biochemical characterization of a novel cold-active alpha-amylase from the Antarctic bacteria Pseudoalteromonas sp. 2-3
AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells
Purification of adenoviral vector serotype 5 for gene therapy against alcoholism using anion exchange chromatography

BookSection (1)

COVID-19 Modeling Under Uncertainty: Statistical Data Analysis for Unveiling True Spreading Dynamics and Guiding Correct Epidemiological Management

ConferencePoster (12)

High-density expansion and metabolic characterization of human adipose and Wharton's jelly mesenchymal stem cells in scalable microcarrier suspension culture
Scaling up the expansion of mesenchymal stem cells derived from Wharton's jelly using microcarriers in bioreactors for clinical applicatsion
Bone Marrow Mesenchymal Stem Cells Therapy for the treatment of Premature Ovarian Insufficiency: a systematic review and meta-analysis of preclinical studies
Evaluating conditions for culturing Human Wharton's Jelly Stem Cells in suspension with microcarriers under xeno-free conditions
Mathematical modeling for 3D design of a tangential flow filtration system for mesenchymal stem cells harvest
Metabolic characterization of high-density microcarrier suspension culture of human adipose and Wharton’s Jelly Mesenchymal Stem Cells
Scalable High-Density Microcarrier Suspension Culture of Human Adipose and Wharton's Jelly Mesenchymal Stem Cells
Primary and suspension culture of mesenchymal stem cells isolated from umbilical cord
Enhancement of Human Adipose derived Stem Cells proliferation by pyruvate and nicotinamide enrichment”
Metabolic profile characterization of mesenchymal stem cells in a microcarrier suspension culture
Recombinant AAV and scAAV vectors for alcoholism treatment: Inhibiting aldh2 gene expression in human hepatoma cells
Production and purification of recombinant AAV and scAAV for Inhibition of ALDH2 gene expression in human hepatoma cells

Proyecto (6)

Efficient scale-up production of Mesenchymal stem cells derived from human Wharton’s Jelly: a cell therapy for premature ovarian insufficiency
Development of enzymes from extremophiles for the degradation of plastics and potential generation of useful metabolites
“Scale-up of human Adipose-derived Stem Cells culture for diabetes type 1 cell therapy
VECTORES VIRALES RECOMBINANTES AAV Y scAAV PARA TERAPIA GÉNICA CONTRA EL ALCOHOLISMO=> INHIBICIÓN DE LA ENZIMA ALDEHÍDO DESHIDROGENASA MITOCONDRIAL EN CÉLULAS DE HEPATOMA HUMANAS
VECTORES VIRALES RECOMBINANTES AAV Y scAAV PARA TERAPIA GÉNICA CONTRA EL ALCOHOLISMO: INHIBICIÓN DE LA ENZIMA ALDEHÍDO DESHIDROGENASA
VECTORES ADENOVIRALES PARA LA TERAPIA GéNICA EN EL TRATAMIENTO DEL ALCOHOLISMO
1
Carlos Conca

CO-FOUNDER ASSOCIATE RESEARCHER

CENTER FOR MATHEMATICAL MODELING

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Irene Martínez

Associate Professor

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

4
Alvaro Olivera

Principal Investigator and Assistant Professor

Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Barbara Andrews

FULL PROFESSOR

CHEMICAL ENGINEERING AND BIOTECHNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Alicia Lucero

Responsable de Transferencia Tecnológica

Fundación Leitat Chile

Santiago, Chile

1
Marcelo Navarrete

Profesor Titular

Medicina

Universidad de Magallanes

Punta Arenas, Chile

29
Anamaria Daza

Investigadora

Centre for Biotechnology and Bioengineering

Santiago, Chile

1
Roberto Uribe-Paredes

Académico

Ingeniería en Computación

Universidad de Magallanes

Punta Arenas, Chile

2
David Medina

Assistant Professor

Departamento de Ingeniería en Computación

Universidad de Magallanes

Punta Arenas, Chile

1
Nyna Llanovarced

Tesista de doctorado

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

3
Karen Oróstica

Vigilancia genómica

Genética Molecular

Universidad de Tal

Santiago, Chile

1
Julieta Sepúlveda

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad de Magallanes

Punta Arenas, Chile

1
LINDYBETH SARMIENTO

Asistente de Investigación y Docencia

Centro Asistencial Docente CADI-UMAG

Universidad de Magallanes

Punta Arenas, Chile