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Barbara Anne Andrews Farrow

FULL PROFESSOR

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Protein Engineering. Metabolic Engineering. Extremophiles.

BIOCHEMISTRY, UNIVERSITY OF LONDON. Reino Unido, 1974
BIOCHEMICAL ENGINEERING, UNIVERSITY OF LONDON. Chile, 1985

RESEARCH ASSOCIATE Full Time

COLUMBIA UNIVERSITY

NEW YORK, Estados Unidos

1982 - 1986
SENIOR RESEARCH ASSOCIATE Full Time

UNIVERSITY OF READING

Reino Unido

1987 - 1994
ASSOCIATE PROFESSOR Full Time

UNIVERSIDAD DE CHILE

PHYSICAL AND MATHEMATICAL SCIENCES

Chile

1996 - 2004
FULL PROFESSOR Full Time

UNIVERSIDAD DE CHILE

PHYSICAL AND MATHEMATICAL SCIENCES

Chile

2004 - A la fecha

In the past 3 years the thesis directed are:
6 Undergraduate: Adriana López (2010), Gabriela Sandoval (2011), Daniela Vaisman (2011), Mauricio Azocar (2011), Alessandra Baldecchi (2013), Camila Bay (2013)
4 Magíster: Gabriela Sandoval (2011), Daniela Vaisman (2011), Camila Wilkens (2011), Mauricio Azocar (2011)
2 PhD: Juan Matias Saavedra (2011), María Paz Merino (2012)

Patentes
Ortogados
US Patent: “Protein and Nucleic Acid Sequence Encoding a Krill-Derived Cold Adapted Trypsin-Like Activity Enzyme”, US 7,202,074 B2, Apr. 10, 2007. Inventors: Asenjo J.A., Andrews, B.A.,Reyes, F., Salamanca M., Burzio L.
US Patent: “Materials and Methods for Regulating Process Formation in Cell Culture”, US 7,323,333 B2, Jan. 29, 2008, Inventors: Caviedes, P., Caviedes, R., Freeman, T.B., Asenjo J.A., Andrews, B.A., Sepulveda D., Arriagada,C., Rivera, J.S.
US Patent: “Methods for Cell Therapy”, US 8,252,279 B2, Aug. 28, 2012, Inventors: Caviedes, P., Caviedes, R., Freeman, T.B., Asenjo J.A., Andrews, B.A., Sepulveda D., Arriagada,C., Rivera, J.S.

Solicitados
US Patent: “Protein and DNA Sequence Encoding a Cold Adapted Subtilisin-Like Activity”, US Provisional Application 60/954/198, August 6, 2007. Inventors: Asenjo, J.A., Andrews, B.A.,Reyes, Acevedo, J.P., Burzio L.

US Patent: “Protein and DNA Sequence Encoding a Cold Adapted Xylanase”, US Provisional Application 61/150, 545, February 6, 2009. Inventors: Asenjo, J.A., Andrews, B.A., Acevedo, J.P., Parra, L. Burzio L.


Atacama Database: a platform of the microbiome of the Atacama Desert Contador C.A.; Veas-Castillo L.; Tapia E.; AntipÃ¡n M.; Miranda N.; Ruiz-Tagle B.; GarcÃa-Araya J.; Andrews B.A.; Marin M.; Dorador C.; Asenjo, J.A Article ISI SCOPUS ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2020)
Cutting the Gordian knot: early and complete amino acid sequence confirmation of class II lasso peptides by HCD fragmentation Jarmusch, Scott A.; Feldmann, Ingo; Blank-Landeshammer, Bernhard; Cortes-Albayay, Carlos; Franco Castro, Jean; Andrews, Barbara; Asenjo, Juan A.; Sickmann, Albert; Ebel, Rainer; Jaspars, Marcel Article ISI JOURNAL OF ANTIBIOTICS (2020)
Downsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle Cortes-Albayay, Carlos; Jarmusch, Scott A.; Trusch, Franziska; Ebel, Rainer; Andrews, Barbara A.; Jaspars, Marcel; Asenjo, Juan A. Article ISI SCOPUS JOURNAL OF ORGANIC CHEMISTRY (2020)
Heterologous expression and biochemical characterization of a novel cold-active alpha-amylase from the Antarctic bacteria Pseudoalteromonas sp. 2-3 Sanchez, AC; Ravanal, MC.; Andrews, BA; Asenjo, JA Article ISI SCOPUS PROTEIN EXPRESSION AND PURIFICATION (2019)
Heterologous Expression of a Cryptic Gene Cluster from Streptomyces leeuwenhoekii C34(T) Yields a Novel Lasso Peptide, Leepeptin Gomez-Escribano, Juan Pablo; Castro, Jean Franco; Razmilic, Valeria; Jarmusch, Scott A.; Saalbach, Gerhard; Ebel, Rainer; Jaspars, Marcel; Andrews, Barbara; Asenjo, Juan A.; Bibb, Mervyn J.; McBain, Andrew J. Article ISI SCOPUS APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2019)
Micromonospora acroterricola sp. nov., a novel actinobacterium isolated from a high altitude Atacama Desert soil Carro L.; Golinska P.; Nouioui I.; Bull A.T.; Igual J.M.; Andrews B.A.; Klenk H.-P.; Goodfellow M. Article ISI SCOPUS INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2019)
New genus-specific primers for PCR identification of Rubrobacter strains Castro, Jean Franco; Nouioui, Imen; Asenjo, Juan A.; Andrews, Barbara; Bull, Alan T.; Goodfellow, Michael Article ISI SCOPUS ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2019)
Streptomyces altiplanensis sp. nov., an alkalitolerant species isolated from Chilean Altiplano soil, and emended description of Streptomyces chryseus (Krasil'nikov et al. 1965) Pridham 1970 Cortes-Abayay, Carlos; Dorador, Cristina; Schumann, Peter; Schniete, Jana K.; Herron, Paul; Andrews, Barbara; Asenjo, Juan.; Nouioui, Imen Article ISI SCOPUS INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2019)
Streptomyces huasconensis sp. nov., an haloalkalitolerant actinobacterium isolated from a high altitude saline wetland at the Chilean Altiplano Cortes-Abayay, Carlos; Dorador, Cristina; Schumann, Peter; Andrews, Barbara; Asenjo, Juan.; Nouioui, Imen Article ISI SCOPUS INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2019)
The Polyextreme Ecosystem, Salar de Huasco at the Chilean Altiplano of the Atacama Desert Houses Diverse Streptomyces spp. with Promising Pharmaceutical Potentials Cortes-Albayay, Carlos; Silber, Johanna; Imhoff, Johannes F.; Asenjo, Juan A.; Andrews, Barbara; Nouioui, Imen; Dorador, Cristina Article ISI SCOPUS DIVERSITY-BASEL (2019)
Use of genome-scale models to get new insights into the marine actinomycete genus Salinispora Contador, Carolina A.; Rodriguez, Vida; Andrews, Barbara A.; Asenjo, Juan A. Article ISI SCOPUS BMC SYSTEMS BIOLOGY (2019)
Amycolatopsis vastitatis sp nov., an isolate from a high altitude subsurface soil on Cerro Chajnantor, northern Chile Idris, H; Nouioui, I; Pathom-aree, W; Castro, JF; Bull, AT; Andrews, BA; Asenjo, JA; Goodfellow M. Article ISI SCOPUS ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2018)
Analysis of metabolic networks of Streptomyces leeuwenhoekii C34 by means of a genome scale model: Prediction of modifications that enhance the production of specialized metabolites Razmilic, Valeria; Castro, Jean F.; Andrews, Barbara; Asenjo, Juan A. Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2018)
Blastococcus atacamensis sp nov., a novel strain adapted to life in the Yungay core region of the Atacama Desert Castro, JF; Nouioui, I; Sangal, V; Choi, S; Yang, SJ; Kim, BY; Trujillo, ME; Riesco, R; Montero-Calasanz, MD; Rahmani, TPD; Bull, AT; Sutcliffe, IC; Asenjo, JA; Andrews B.; Goodfellow M. Article ISI SCOPUS INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2018)
Geodermatophilus chilensis sp nov., from soil of the Yungay core-region of the Atacama Desert, Chile Castro, JF; Nouioui, I; Sangal, V; Trujillo, ME; Montero-Calasanz, MD; Rahmani, T; Bull, AT; Asenjo, JA; Andrews, BA; Goodfellow M. Article ISI SCOPUS SYSTEMATIC AND APPLIED MICROBIOLOGY (2018)
High altitude, hyper-arid soils of the Central-Andes harbor mega-diverse communities of actinobacteria Bull, AT; Idris, H; Sanderson, R; Asenjo, J; Andrews, B; Goodfellow, M Article ISI SCOPUS EXTREMOPHILES (2018)
Metabolic modelling and flux analysis of microorganisms from the Atacama Desert used in biotechnological processes Razmilic, Valeria; Castro, Jean Franco; Marchant, Francisca; Asenjo, Juan A.; Andrews, Barbara Article ISI SCOPUS ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2018)
Relevance of Local Flexibility Near the Active Site for Enzymatic Catalysis: Biochemical Characterization and Engineering of Cellulase Cel5A From Bacillus agaradherans Saavedra, Juan M.; Azócar, Mauricio A.; Rodríguez, Vida; Ramírez-Sarmiento, César A.; Andrews, Barbara A.; Asenjo, Juan A.; Parra, Loreto P. Article ISI SCOPUS BIOTECHNOLOGY JOURNAL (2018)
AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells Sanchez, AC; Li, CW; Andrews, B; Asenjo, JA; Samulski, RJ Article ISI SCOPUS Human Gene Therapy (2017)
Purification of adenoviral vector serotype 5 for gene therapy against alcoholism using anion exchange chromatography 92. Lucero, A.T., Mercado, S.A., Sánchez, A.C., Contador, C.A., Andrews, B.A. and Asenjo, J.A. Article ISI J. Chem. Technol. Biotechnol (2017)
Streptomyces asenjonii sp nov., isolated from hyper-arid Atacama Desert soils and emended description of Streptomyces viridosporus Pridham et al. 1958 Goodfellow M.; Busarakam K.; Idris H.; Labeda D.P.; Nouioui I.; Brown R.; Kim B.-Y.; del Carmen Montero-Calasanz M.; Andrews B.A.; Bull A.T. Article ISI SCOPUS ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2017)
Acidithiobacillus ferrooxidans's comprehensive model driven analysis of the electron transfer metabolism and synthetic strain design for biomining applications Campodonico M.A.; Vaisman D.; Castro, J.F.; Razmilic, V; Mercado, F; Andrews B.A.; Feist A.M.; Asenjo, J.A Article SCOPUS Metabolic Engineering Communications (2016)
Characterization of Ferroplasma acidiphilum growing in pure and mixed culture with Leptospirilum ferriphilum 91. Merino, M.P., Andrews, B.A., Parada, P. and Asenjo, J.A. Article isi Biotechnol. Prog (2016)
Analyzing redox balance in a synthetic yeast platform to improve utilization of brown macroalgae as feedstock Contador C.A.; Shene C.; Olivera, A.; Yoshikuni Y.; Buschmann A.; Andrews B.A.; Asenjo, J.A Article SCOPUS Metabolic Engineering Communications (2015)
Genome-scale reconstruction of Salinispora tropica CNB-440 metabolism to study strain-specific adaptation Contador CA; Rodríguez, V.; Andrews, BA; Asenjo, JA Article ISI SCOPUS Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology (2015)
Identification and Heterologous Expression of the Chaxamycin Biosynthesis Gene Cluster from Streptomyces leeuwenhoekii Castro, Jean Franco; Razmilic, Valeria; Gomez-Escribano, Juan Pablo; Andrews, Barbara; Asenjo, Juan A.; Bibb, Mervyn J.; Elliot, M. A. Article ISI SCOPUS Applied and Environmental Microbiology (2015)
Identification of lipase encoding genes from Antarctic seawater bacteria using degenerate primers: Expression of a cold-active lipase with high specific activity Parra L.P.; Espina, G; Devia, J; Salazar, O; Andrews B.; Asenjo, J.A Article ISI SCOPUS ENZYME AND MICROBIAL TECHNOLOGY (2015)
Production of Cell-Penetrating Peptides in Escherichia coli Using an Intein-Mediated System Rodríguez, Vida; Lascani, Jorge; Asenjo, Juan A.; Andrews, Barbara A. Article ISI SCOPUS Applied Biochemistry and Biotechnology (2015)
Stoichiometric Model and Flux Balance Analysis for a Mixed Culture of Leptospirillum ferriphilum and Ferroplasma acidiphilum Merino, M. P.; Andrews B.A.; Asenjo, J.A Article ISI SCOPUS Biotechnology Progress (2015)
The Streptomyces leeuwenhoekii genome: de novo sequencing and assembly in single contigs of the chromosome, circular plasmid pSLE1 and linear plasmid pSLE2 Gomez-Escribano, JP; Castro, JF; Razmilic, V; Chandra, G; Andrews B.; Asenjo, JA; Bibb, MJ Article ISI SCOPUS BMC Genomics (2015)
Design and implementation of a high yield production system for recombinant expression of peptides Rodríguez, V.; Asenjo, JA; Andrews, BA Article ISI SCOPUS MICROBIAL CELL FACTORIES (2014)
Generation of an atlas for commodity chemical production in Escherichia coli and a novel pathway prediction algorithm, GEM-Path Campodonico, MA; Andrews, BA; Asenjo, JA; Palsson, BO; Feist, AM Article ISI SCOPUS METABOLIC ENGINEERING (2014)
Cloning, expression and decoding of the cold adaptation of a new widely represented thermolabile subtilisin-like protease Acevedo, JP; Rodríguez, V.; Saavedra M.; Munoz M.; Salazar, O; Asenjo, JA; Andrews, BA Article ISI SCOPUS Journal of Applied Microbiology (2013)
Cloning, expression and decoding of the cold adaptation of a new widely represented thermolabile subtilisin-like protease. Acevedo, J P; Rodriguez, V; Saavedra, M; Muñoz, M; Salazar, O; Asenjo, J A; Andrews, B A Article Journal of applied microbiology (2013)
Cold Adaptation, Ca2+ Dependency and Autolytic Stability Are Related Features in a Highly Active Cold-Adapted Trypsin Resistant to Autoproteolysis Engineered for Biotechnological Applications Olivera-Nappa, A.; Reyes, F.; Andrews, BA; Asenjo, JA Article ISI SCOPUS PLOS ONE (2013)
Cold Adaptation, Ca2+ Dependency and Autolytic Stability Are Related Features in a Highly Active Cold-Adapted Trypsin Resistant to Autoproteolysis Engineered for Biotechnological Applications Olivera-Nappa, A; Reyes, F; Andrews, BA; Asenjo, JA Article PLOS ONE (2013)
Streptomyces bullii sp nov., isolated from a hyper-arid Atacama Desert soil Santhanam, R; Rong, XY; Huang, Y; Andrews, BA; Asenjo, JA; Goodfellow M. Article ISI SCOPUS Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology (2013)
Streptomyces bullii sp. nov., isolated from a hyper-arid Atacama Desert soil. Santhanam, Rakesh; Rong, Xiaoying; Huang, Ying; Andrews, Barbara A; Asenjo, Juan A; Goodfellow, Michael Article Antonie van Leeuwenhoek (2013)
Aqueous two-phase systems for protein separation: Phase separation and applications Asenjo, J.A; Andrews B.A. Article ISI SCOPUS Journal of Chromatography A (2012)
Aqueous two-phase systems for protein separation=> phase separation and applications. Asenjo, Juan A; Andrews, Barbara A Article Journal of chromatography. A (2012)
Continuous modeling of metabolic networks with gene regulation in yeast and in vivo determination of rate parameters Moisset, P; Vaisman D.; Cintolesi, A.; Urrutia, J; Rapaport, I; Andrews B.A.; Asenjo, J.A Article ISI SCOPUS Biotechnology and Bioengineering (2012)
Continuous modeling of metabolic networks with gene regulation in yeast and in vivo determination of rate parameters. Moisset, P; Vaisman, D; Cintolesi, A; Urrutia, J; Rapaport, I; Andrews, B A; Asenjo, J A Article Biotechnology and bioengineering (2012)
Elution relationships to model affinity chromatography using a general rate model Sandoval, G; Andrews B.A.; Asenjo, J.A Article ISI SCOPUS Journal of Molecular Recognition (2012)
Elution relationships to model affinity chromatography using a general rate model. Sandoval, Gabriela; Andrews, Barbara A; Asenjo, Juan A Article Journal of molecular recognition => JMR (2012)
Hydrophobic interaction chromatography for purification of monoPEGylated RNase A Mayolo-Deloisa K.; Lienqueo M.E.; Andrews B.; Rito-Palomares M.; Asenjo, J.A Article ISI SCOPUS Journal of Chromatography A (2012)
Hydrophobic interaction chromatography for purification of monoPEGylated RNase A. Mayolo-Deloisa, Karla; Lienqueo, Ma Elena; Andrews, Barbara; Rito-Palomares, Marco; Asenjo, Juan A Article Journal of chromatography. A (2012)
Streptomyces atacamensis sp nov., isolated from an extreme hyper-arid soil of the Atacama Desert, Chile Santhanam, R; Okoro C.K.; Rong X.; Huang, Y; Bull A.T.; Weon H.-Y.; Andrews B.A.; Asenjo, J.A; Goodfellow M. Article ISI SCOPUS International Journal of Systematic and Evolutionary Microbiology (2012)
Streptomyces atacamensis sp. nov., isolated from an extreme hyper-arid soil of the Atacama Desert, Chile. Santhanam, Rakesh; Okoro, Chinyere K; Rong, Xiaoying; Huang, Ying; Bull, Alan T; Weon, Hang-Yeon; Andrews, Barbara A; Asenjo, Juan A; Goodfellow, Michael Article International journal of systematic and evolutionary microbiology (2012)
Streptomyces deserti sp nov., isolated from hyper-arid Atacama Desert soil Santhanam, R; Okoro C.K.; Rong X.; Huang, Y; Bull A.T.; Andrews B.A.; Asenjo, J.A; Weon H.-Y.; Goodfellow M. Article ISI SCOPUS Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology (2012)
Streptomyces deserti sp. nov., isolated from hyper-arid Atacama Desert soil. Santhanam, Rakesh; Okoro, Chinyere K; Rong, Xiaoying; Huang, Ying; Bull, Alan T; Andrews, Barbara A; Asenjo, Juan A; Weon, Hang-Yeon; Goodfellow, Michael Article Antonie van Leeuwenhoek (2012)
Aqueous two-phase systems for protein separation=> a perspective. Asenjo, Juan A; Andrews, Barbara A Article Journal of chromatography. A (2011)
Chaxamycins A-D, Bioactive Ansamycins from a Hyper-arid Desert Streptomyces sp. Rateb, ME; Houssen, WE; Arnold, M; Abdelrahman, MH; Deng, H.; Harrison, WTA; Okoro, CK; Asenjo, JA; Andrews, BA; Ferguson G.; Bull, AT; Goodfellow M.; Ebel, R.; Jaspars, M Article ISI SCOPUS Journal of Natural Products (2011)
Chaxamycins A-D, bioactive ansamycins from a hyper-arid desert Streptomyces sp. Rateb, Mostafa E; Houssen, Wael E; Arnold, Markus; Abdelrahman, Mostafa H; Deng, Hai; Harrison, William T A; Okoro, Chinyere K; Asenjo, Juan A; Andrews, Barbara A; Ferguson, Gail; Bull, Alan T; Goodfellow, Michael; Ebel, Rainer; Jaspars, Marcel Article Journal of natural products (2011)
Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment Rateb, ME; Houssen, WE; Harrison, WTA; Deng, H.; Okoro, CK; Asenjo, JA; Andrews, BA; Bull, AT; Goodfellow M.; Ebel, R.; Jaspars, M Article ISI SCOPUS Journal of Natural Products (2011)
Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment. Rateb, Mostafa E; Houssen, Wael E; Harrison, William T A; Deng, Hai; Okoro, Chinyere K; Asenjo, Juan A; Andrews, Barbara A; Bull, Alan T; Goodfellow, Michael; Ebel, Rainer; Jaspars, Marcel Article Journal of natural products (2011)
Identification of Transcription Factors Perturbed by the Synthesis of High Levels of a Foreign Protein in Yeast Saccharomyces cerevisiae Contador CA; Andrews, BA; Liao, JC; Asenjo, JA Article ISI SCOPUS Biotechnology Progress (2011)
Identification of transcription factors perturbed by the synthesis of high levels of a foreign protein in yeast Saccharomyces cerevisiae. Contador, Carolina A; Andrews, Barbara A; Liao, James C; Asenjo, Juan A Article Biotechnology progress (2011)
Mutagenesis Objective Search and Selection Tool (MOSST): an algorithm to predict structure-function related mutations in proteins Olivera-Nappa, A.; Andrews, BA; Asenjo, JA Article ISI SCOPUS BMC Bioinformatics (2011)
Mutagenesis Objective Search and Selection Tool (MOSST)=> an algorithm to predict structure-function related mutations in proteins. Olivera-Nappa, Alvaro; Andrews, Barbara A; Asenjo, Juan A Article BMC bioinformatics (2011)
Extension of the selection of protein chromatography and the rate model to affinity chromatography Sandoval, G; Shene C.; Andrews, BA; Asenjo, JA Article ISI SCOPUS Journal of Molecular Recognition (2010)
Metabolic Flux Analysis of Embryonic Stem Cells Using Three Distinct Differentiation Protocols and Comparison to Gene Expression Patterns Sepulveda, DE; Andrews, BA; Papoutsakis, ET; Asenjo, JA Article ISI SCOPUS Biotechnology progress (2010)
Stoichiometric Model and Metabolic Flux Analysis for Leptospirillum ferrooxidans Merino, MP; Andrews, BA; Asenjo, JA Article ISI SCOPUS Biotechnology and Bioengineering (2010)
Stoichiometric model and metabolic flux analysis for Leptospirillum ferrooxidans. Merino, M P; Andrews, B A; Asenjo, J A Article Biotechnology and bioengineering (2010)
Theoretical and Experimental Evaluation of Hydrophobicity of Proteins to Predict their Partitioning Behavior in Aqueous Two Phase Systems: A Review Andrews, BA; Asenjo, JA Article ISI SCOPUS Separation Science and Technology (Philadelphia) (2010)
Viral vectors for the treatment of alcoholism: Use of metabolic flux analysis for cell cultivation and vector production Martínez V; Gerdtzen ZP; Andrews, BA; Asenjo, JA Article ISI SCOPUS METABOLIC ENGINEERING (2010)
Viral vectors for the treatment of alcoholism=> Use of metabolic flux analysis for cell cultivation and vector production 61. Martinez, V.; Gerdtzen, Z. P.; Andrews, B. A.; Asenjo, J. A Article Metabolic Engineering (2010)
Viral vectors for the treatment of alcoholism=> use of metabolic flux analysis for cell cultivation and vector production. Martinez, V; Gerdtzen, Z P; Andrews, B A; Asenjo, J A Article Metabolic engineering (2010)
A Stoichiometric Model of Acidithiobacillus ferrooxidans ATCC 23270 for Metabolic Flux Analysis Hold, C; Andrews, BA; Asenjo, JA Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2009)
A stoichiometric model of Acidithiobacillus ferrooxidans ATCC 23270 for metabolic flux analysis. Hold, C; Andrews, B A; Asenjo, J A Article Biotechnology and bioengineering (2009)
Diversity of culturable actinomycetes in hyper-arid soils of the Atacama Desert, Chile Okoro, CK; Brown, R; Jones, AL; Andrews, BA; Asenjo, JA; Goodfellow M.; Bull, AT Article ISI SCOPUS ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2009)
Diversity of culturable actinomycetes in hyper-arid soils of the Atacama Desert, Chile. Okoro, Chinyere K; Brown, Roselyn; Jones, Amanda L; Andrews, Barbara A; Asenjo, Juan A; Goodfellow, Michael; Bull, Alan T Article Antonie van Leeuwenhoek (2009)
Global gene expression in recombinant and non-recombinant yeast Saccharomyces cerevisiae in three different metabolic states Diáz, H.; Andrews, BA; Hayes, A; Castrillo, J; Oliver, SG; Asenjo, JA Article ISI SCOPUS BIOTECHNOLOGY ADVANCES (2009)
Global gene expression in recombinant and non-recombinant yeast Saccharomyces cerevisiae in three different metabolic states Díaz, H.; Andrews, B.A.; Hayes, A.; Castrillo, J.; Oliver, S. and Asenjo Article Biotech. Advances (2009)
Modeling heterocyst pattern formation in cyanobacteria Gerdtzen ZP; Salgado JC; Osses A.; Asenjo, JA; Rapaport, I; Andrews, BA Article ISI SCOPUS BMC Bioinformatics (2009)
Protein purification using chromatography: selection of type, modelling and optimization of operating conditions Asenjo, JA; Andrews, BA Article ISI SCOPUS JOURNAL OF MOLECULAR RECOGNITION (2009)
Cloning and fusion expression of a cold-active lipase from marine Antarctic origin Parra, LP; Reyes, F.; Acevedo, JP; Salazar, O; Andrews, BA; Asenjo, JA Article ISI SCOPUS ENZYME AND MICROBIAL TECHNOLOGY (2008)
Cloning of complete genes for novel hydrolytic enzymes from Antarctic sea water bacteria by use of an improved genome walking technique Acevedo, JP; Reyes, F.; Parra, LP; Salazar, O; Andrews, BA; Asenjo, JA Article ISI SCOPUS JOURNAL OF BIOTECHNOLOGY (2008)
Cloning of complete genes for novel hydrolytic enzymes from Antarctic sea water bacteria by use of an improved genome walking technique. Acevedo, Juan Pablo; Reyes, Fernando; Parra, Loreto P; Salazar, Oriana; Andrews, Barbara A; Asenjo, Juan A Article Journal of biotechnology (2008)
Comparative Transcriptional Analysis of Embryoid Body Versus Two-Dimensional Differentiation of Murine Embryonic Stem Cells Sepulveda, DE; Andrews, BA; Asenjo, JA; Papoutsakis, ET Article ISI SCOPUS TISSUE ENGINEERING PART A (2008)
Comparative transcriptional analysis of embryoid body versus two-dimensional differentiation of murine embryonic stem cells. Sepulveda, Dario E; Andrews, Barbara A; Asenjo, Juan A; Papoutsakis, Eleftherios Terry Article Tissue engineering. Part A (2008)
Prediction of the partitioning behaviour of proteins in aqueous two-phase systems using only their amino acid composition Salgado JC; Andrews, BA; Ortuzar, MF; Asenjo, JA Article ISI SCOPUS JOURNAL OF CHROMATOGRAPHY A (2008)
Prediction of the partitioning behaviour of proteins in aqueous two-phase systems using only their amino acid composition. Salgado, J Cristian; Andrews, Barbara A; Ortuzar, Maria Fernanda; Asenjo, Juan A Article Journal of chromatography. A (2008)
A discrete mathematical model applied to genetic regulation and metabolic networks Asenjo, JA; Ramirez, P; Rapaport, I; Aracena, J; Goles, E.; Andrews, BA Article ISI SCOPUS JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2007)
Mathematical modeling of elution curves for a protein mixture in ion exchange chromatography and for the optimal selection of operational conditions Shene C.; Lucero A.; Andrews, BA; Asenjo, JA Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2006)
Correlation for the partition behavior of proteins in aqueous two-phase systems: Effect of surface hydrophobicity and charge Andrews, BA; Schmidt, AS; Asenjo, JA Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2005)
A mixed mechanistic-electrostatic model to explain pH dependence of glycosyl hydrolase enzyme activity Olivera-Nappa, A.; Andrews, BA; Asenjo, JA Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2004)
EFFECT OF ELECTROSTATIC ENERGY ON PARTITIONING OF PROTEINS IN AQUEOUS TWO-PHASE SYSTEMS Olivera-Nappa, A.; Lagomarsino, Gian; Andrews, Barbara; Asenjo, Juan. Article JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2004)
Optimal process synthesis for the production of multiple recombinant proteins Iribarren, OA; Montagna, JM; Vecchietti, AR; Andrews B.; Asenjo, JA; Pinto, JM Article ISI BIOTECHNOLOGY PROGRESS (2004)
Metabolic analysis of the synthesis of high levels of intracellular human SOD in Saccharomyces cerevisiae rhSOD 2060 411 SGA122 González R.; Andrews, BA; Molitor, J; Asenjo, JA Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2003)
Study of recombinant micro-organism populations characterized by their plasmid content per cell using a segregated model Shene C.; Andrews, BA; Asenjo, JA Article ISI SCOPUS BIOPROCESS AND BIOSYSTEMS ENGINEERING (2003)
Kinetic model of BiP- and PDI-mediated protein folding and assembly González R.; Andrews, BA; Asenjo, JA Article ISI SCOPUS JOURNAL OF THEORETICAL BIOLOGY (2002)
Phase separation rates of aqueous two-phase systems: Correlation with system properties Asenjo, JA; Mistry, SL; Andrews, BA; Merchuk, JC Article ISI SCOPUS BIOTECHNOLOGY AND BIOENGINEERING (2002)
Refractive index, density, and viscosity in the NaNO 3 + H 2O + poly(ethylene glycol) system at various temperatures Graber T.A.; Galleguillos, H; Asenjo, J.A; Andrews B.A. Article JOURNAL OF CHEMICAL AND ENGINEERING DATA (2002)
Influence of molecular weight of the polymer on the liquid-liquid equilibrium of the poly(ethylene glycol) + NaNo 3 + H 2O system at 298.15 K Graber T.A.; Taboada, M.E.; Asenjo, J.A; Andrews B.A. Article JOURNAL OF CHEMICAL AND ENGINEERING DATA (2001)
Isolation, purification and preliminary characterization of cryophilic proteases of marine origin Salamanca, MH; Barria, C; Asenjo, JA; Andrews, BA Article ISI BIOSEPARATION (2001)
Liquid-liquid and liquid-liquid-solid equilibrium in Na2CO3-PEG-H2O Taboada, ME; Asenjo, JA; Andrews, BA Article ISI SCOPUS FLUID PHASE EQUILIBRIA (2001)
Liquid-liquid and solid-liquid equilibria of the poly(ethylene glycol) plus sodium sulfate plus water system at 298.15 K Taboada, ME; Rocha, OA; Graber, TA; Andrews, BA Article ISI SCOPUS JOURNAL OF CHEMICAL AND ENGINEERING DATA (2001)
Metabolic control analysis of monoclonal antibody synthesis González R.; Asenjo, JA; Andrews, BA Article ISI SCOPUS BIOTECHNOLOGY PROGRESS (2001)
Drowning-out crystallisation of sodium sulphate using aqueous two-phase systems Taboada, ME; Graber, TA; Asenjo, JA; Andrews, BA Article ISI SCOPUS Journal of Chromatography B (2000)
Effect of the growth conditions on the synthesis of a recombinant beta-1,4-endoglucanase in continuous and fed-batch culture Shene C.; Mir, N; Andrews, BA; Asenjo, JA Article ISI SCOPUS ENZYME AND MICROBIAL TECHNOLOGY (2000)
Model for the partition of metal ions in aqueous two-phase systems Graber, TA; Andrews, BA; Asenjo, JA Article ISI SCOPUS Journal of Chromatography B (2000)
Fedbatch fermentations of Bacillus subtilis ToC46 (pPFF1) for the synthesis of a recombinant ?-1,3-glucanase: Experimental study and modelling Shene C.; Andrews B.A.; Asenjo, J.A Article ENZYME AND MICROBIAL TECHNOLOGY (1999)
Aqueous two-phase systems for protein separation studies on phase inversion Merchuk J.C.; Andrews B.A.; Asenjo, J.A Article Journal of Chromatography B: Biomedical Applications (1998)
On the kinetics of phase separation in aqueous two-phase systems Salamanca M.H.; Andrews B.A.; Asenjo, J.A; Merchuk J.C. Article Journal of Chromatography B: Biomedical Applications (1998)
Yeast cell permeabilizing ?-1,3-glucanases: A tool for the integration of downstream processes and metabolic engineering applications to yeast Ferrer, P; Asenjo, J.A; Andrews B.A.; Diers I. Article BIOTECHNOLOGY AND BIOENGINEERING (1998)
Correlations for the partition behavior of proteins in aqueous two-phase systems: Effect of overall protein concentration Schmidt A.S.; Andrews B.A.; Asenjo, J.A Article BIOTECHNOLOGY AND BIOENGINEERING (1996)
Hydrophobic partitioning of proteins in aqueous two-phase systems Hachem F.; Andrews B.A.; Asenjo, J.A Article ENZYME AND MICROBIAL TECHNOLOGY (1996)
Mathematical modeling of the synthesis of a cloned lytic ?-1,4-endoglucanase in Bacillus subtilis Shene C.; Andrews B.A.; Asenjo, J.A; Mir, N Article ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (1996)
Partitioning and purification of monoclonal antibodies in aqueous two-phase systems Andrews B.A.; Nielsen S.; Asenjo, J.A Article Bioseparation (1996)
Protein partitioning equilibrium between the aqueous poly(ethylene glycol) and salt phases and the solid protein phase in poly(ethylene glycol)-salt two-phase systems Andrews B.A.; Asenjo, J.A Article Journal of Chromatography B: Biomedical Applications (1996)
Extension of the selection of protein chromatography and the rate model to affinity chromatography. Sandoval, G; Shene, C; Andrews, B A; Asenjo, J A Article Journal of molecular recognition => JMR (0)
Metabolic flux analysis of embryonic stem cells using three distinct differentiation protocols and comparison to gene expression patterns. Sepúlveda, Darío E; Andrews, Barbara A; Papoutsakis, Eleftherios Terry; Asenjo, Juan A Article Biotechnology progress (0)
Metabolic flux analysis of embryonic stem cells using three distinct differentiation protocols and comparison to gene expression patterns. Sepúlveda, Darío E; Andrews, Barbara A; Papoutsakis, Eleftherios Terry; Asenjo, Juan A Article Biotechnology progress (0)
Mutagenesis Objective Search and Selectio Tool (MOSST) Olivera-Nappa, A.; Andrews B.A.; Asenjo, J.A Article BMC BIOINFORMATICS
Protein purification using chromatography=> selection of type, modelling and optimization of operating conditions. Asenjo, J A; Andrews, B A Article Journal of molecular recognition => JMR (0)


Optimization and design considerations of two-phase continuous protein separation Huenupi, E; Gomez A.; Andrews B.A.; Asenjo, J.A ConferencePaper JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (1999)


Methods for cell therapy Caviedes P.; Caviedes R.; Freeman, T. B.; Asenjo, J.A; Andrews B.A. Patent (2012)
Protein and DNA sequence encoding a cold adapted xylanase Asenjo, J.A; Andrews B.A.; Acevedo J.P.; Parra, L; Burzio, L Patent (2010)
Protein and DNA sequence encoding a cold adapted-subtilisin-like activity Asenjo, J.A; Andrews B.A.; Acevedo J.P.; Reyes, F.; Burzio, L Patent (2010)
Protein and DNA Sequence Encoding a Cold Adapted Subtilysin-like Activity Asenjo, J.A; Andrews B.A.; Acevedo J.P.; Reyes, F.; Burzio, L Patent (2007)
Protein and nucleic acid sequence encoding a KRILL-derived cold adapted trypsin-like activity enzyme Asenjo, J.A; Andrews B.A.; Reyes, F.; Salamanca M.; Burzio, L Patent (2004)
Materials and Methods for Regulating Process Formation in Cell Culture Caviedes P.; Caviedes R.; Freeman, T. B.; Asenjo, J.A; Andrews B.A.; Sepulveda D.; Arriagada C.; Rivera, J.S. Patent (2003)
Method of Preparing a Yeast-cell lytic Enzyme System Asenjo, J.A; Andrews B.A. Patent (1986)


INTEGRATIVE BIOINFORMATIC TOOLS TO ACCURATELY PREDICT THE EFFECTS OF MUTATIONS IN CANCER-RELATED PROTEINS AND TO GUIDE THE DESIGN OF RATIONAL PROTEIN ENGINEERING STRATEGIES. FONDECYT (1141311) Proyecto 2014-2014 Coinvestigador(a)
“Centro Basal de Biotecnología y Bioingeniería” FONDAP (FB 0001) Proyecto 2014-2019 Inv. Principal
“Instituto Milenio de Estudios Avanzados en Biologia Celular y Biotecnologia” Mideplan (AII01) Proyecto 2014-2029 Investigador(a)
“Adenoviral Vectors for Gene Therapy in the Treatment of Alcoholism” FONDECYT (D08I1051) Proyecto 2009-2013 Director(a)
PREDICTION OF THE PARTITIONING BEHAVIOUR OF PROTEINS IN AQUEOUS TWO-´ASE SUSTEMS USING THEIR THREE DIMENSIONAL STRUCTURE OR THEIR AMINO ACID COMPOSITION FONDECYT (3070031) Proyecto 2007-2008 Inv. Patrocinante
“Millenium Institute for Cell Dynamics and Biotechnology=> A Centre for Systems Biology, ICDB” Mideplan (ICM-P05-001-F) Proyecto 2007-2012 Inv. Principal
METABOLIC ENGINEERING FOR THE OPTIMIZATION OF METABOLISM IN YEAST AND MAMMALIAN CELLS=> MATHEMATICAL MODELLING AND GENOMIC STUDIES FONDECYT (1061119) Proyecto 2006-2009 Inv. Responsable
Research, Development and Production of Commercial Cryophilic Proteases and Lipases of Antarctic Origin FONDECYT (1061119) Proyecto 2005-2008 Director(a)
Investigacion, desarrollo y produccion de proteasas y lipasas criofilicas comerciales de fuentes marinas FONDECYT (D011031) Proyecto 2002-2005 Director(a)
PARTITION OF PROTEINS IN AQUEOUS TWO-PHASE SYSTEMS=> PREDICTION OF BEHAVIOUR USING PHYSICO-CHEMICAL PROPERTIES. FONDECYT (1010142) Proyecto 2001-2004 Inv. Responsable
“Optimizacion de proliferación y diferenciación celular in vitro=> aplicación en terapia transplante celular” Universidad de Chile (DID TCAC 10-02/01) Proyecto 2001-2003 Inv. Responsable
PHASE FORMATION KINETICS AND MODELLING OF THE SEPARATION OF PROTEINS IN AQUEOUS TWO-PHASE SYSTEMS FONDECYT (7980075) Proyecto 1998-2001 Inv. Responsable
PHASE FORMATION KINETICS AND MODELLING OF THE SEPARATION OF PROTEINS IN AQUEOUS TWO-PHASE SYSTEMS FONDECYT (1981186) Proyecto 1998-2001 Inv. Responsable
STUDIES ON THE STRUCTURE-FUNCTION RELATIONSHIP OF A LYTIC B-1,3 - GLUCANASE ABLE TO PERMEABILIZE THE YEAST CELL WALL FONDECYT (3950003) Proyecto 1995-1997 Inv. Patrocinante
SYNTHESIS AND OVERPRODUCTION OF A RECOMBINAT LYTIC GLUCANANSE=> MATHEMATICAL MODELLING, PURIFICATION AND USE. FONDECYT (1950620) Proyecto 1995-1998 Coinvestigador(a)


The gifted actinomycete Streptomyces leeuwenhoekii Castro, JF; Razmilic, V; Gomez-Escribano, JP; Andrews B.; Asenjo, J; Bibb, M Review ISI SCOPUS ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2018)
Aqueous two-phase systems for protein separation: A perspective Asenjo, JA; Andrews, BA Review ISI SCOPUS Journal of Chromatography A (2011)
Challenges and trends in bioseparations Asenjo, JA; Andrews, BA Review ISI JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2008)

106

Barbara Andrews

FULL PROFESSOR

CHEMICAL ENGINEERING AND BIOTECHNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Juan Asenjo

Professor

CHEMICAL AND BIOTECHNOLOGY ENGINEERING

University of Chile

SANTIAGO, Chile

Jean Castro

Curador

Banco de Recursos Genéticos Microbiano

Instituto de Investigaciones Agropecuarias

Chillán, Chile

Carolina Shene

TITULAR PROFESSOR

CHEMICAL ENGINEERING

UNIVERSIDAD DE LA FRONTERA

TEMUCO, Chile

Valeria Razmilic

Investigadora postdoctoral

Centro de Biotecnología y Bioingeniería

Universidad de Chile

Santiago, Chile

Vida Rodríguez

Investigadora Postdoctoral

Universidad de Chile

Santiago, Chile

Maria Salazar

Profesora Asociada

UNIVERSIDAD DE CHILE, FAC. DE CIENCIAS FÍSICAS Y MATEMATICAS DEPTO. INGENIERÍA QUÍMICA

Santiago, Chile

Carlos Cortés

Postdoctoral Researcher

Scientific and Technological Bioresources Nucleus (BIOREN)

Universidad de La Frontera

Temuco, Chile

loreto parra

Assitant Professor

Chemical and Bioprocesses Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

Alvaro Olivera

Principal Investigator and Assistant Professor

Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

Cristina Dorador

PROFESSOR

Biotechnology

UNIVERSIDAD DE ANTOFAGASTA

ANTOFAGASTA, Chile

Ivan Rapaport

Full Professor

Mathematical Engineering

Universidad de Chile

Santiago, Chile

Maria Taboada

Profesor Titular

Facultad de Ingeniería

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Teófilo Graber

Académico. Profesor Titular

Ingeniería Química

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Anamaria Daza

Investigadora

Centre for Biotechnology and Bioengineering

Santiago, Chile

Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

Daniela Vaisman

Ingeniera de Proyectos

Centro de Biotecnología y Bioingeniería

Santiago, Chile

Ziomara Gerdtzen

Profesora Asociada

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

Pablo Moisset de Espanés

Investigador asociado

FCFM

CeBiB, Universidad de Chile

Santiago, Chile

Gabriela Sandoval

Jefe de carrera

Departamento de Ingeniería Química

Universidad Tecnológica Metropolitana

Santiago, Chile

Angela Cintolesi Makuc

Postdoctorado

Centro de Modelamiento Matemático

Universidad de Chile

Santiago, Chile

Eric Goles

Full Professor

Facultad de Ingeniería y Ciencias

Universidad Adolfo Ibáñez

Santiago, Chile

Julio Aracena

Full Professor

Ingeniería Martemática

Universidad de Concepción

Concepción, Chile

José Salgado

Associate Professor

Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

Alejandro Buschmann

FULL PROFESSOR

UNIVERSIDAD DE LOS LAGOS

PUERTO MONTT, Chile

Francisca Marchant

Research assistant

Universidad de Chile

Santiago, Chile

FRANCESCA MERCADO

Gerente de Calidad y Sostenibilidad

Operaciones

Wurth Group

Santiago, Chile

Giannina Espina

Research Scientist

Fundacion Biociencia

Santiago, Chile

Maria Lienqueo

FULL PROFESSOR

OF CHEMICAL AND BIOTECHNOLOGY ENGINEERING

UNIVERSIDAD DE CHILE

Santiago, Chile

Alicia Lucero

Responsable de Transferencia Tecnológica

Fundación Leitat Chile

Santiago, Chile

Axel Osses

Profesor Titular

Departamento de Ingeniería Matemática

Universidad de Chile

Santiago, Chile

CESAR RAMIREZ

Assistant Professor

Institute for Biological and Medical Engineering

Pontificia Universidad Catolica de Chile

Santiago, Chile

Mauricio Marin

professor

Informatics Engineering

University of Santiago

Santiago, Chile

Luis Veas

Académico

Ingeniería Informática

Universidad Austral de Chile

Valdivia, Chile

Barbara Anne Andrews Farrow

Líneas de Investigación

Educación

BIOCHEMISTRY, UNIVERSITY OF LONDON. Reino Unido, 1974

BIOCHEMICAL ENGINEERING, UNIVERSITY OF LONDON. Chile, 1985

Experiencia Académica

RESEARCH ASSOCIATE Full Time

SENIOR RESEARCH ASSOCIATE Full Time

ASSOCIATE PROFESSOR Full Time

FULL PROFESSOR Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (115)

ConferencePaper (1)

Patent (7)

Proyecto (15)

INTEGRATIVE BIOINFORMATIC TOOLS TO ACCURATELY PREDICT THE EFFECTS OF MUTATIONS IN CANCER-RELATED PROTEINS AND TO GUIDE THE DESIGN OF RATIONAL PROTEIN ENGINEERING STRATEGIES.

“Centro Basal de Biotecnología y Bioingeniería”

“Instituto Milenio de Estudios Avanzados en Biologia Celular y Biotecnologia”

“Adenoviral Vectors for Gene Therapy in the Treatment of Alcoholism”

PREDICTION OF THE PARTITIONING BEHAVIOUR OF PROTEINS IN AQUEOUS TWO-´ASE SUSTEMS USING THEIR THREE DIMENSIONAL STRUCTURE OR THEIR AMINO ACID COMPOSITION

“Millenium Institute for Cell Dynamics and Biotechnology=> A Centre for Systems Biology, ICDB”

METABOLIC ENGINEERING FOR THE OPTIMIZATION OF METABOLISM IN YEAST AND MAMMALIAN CELLS=> MATHEMATICAL MODELLING AND GENOMIC STUDIES

Research, Development and Production of Commercial Cryophilic Proteases and Lipases of Antarctic Origin

Investigacion, desarrollo y produccion de proteasas y lipasas criofilicas comerciales de fuentes marinas

PARTITION OF PROTEINS IN AQUEOUS TWO-PHASE SYSTEMS=> PREDICTION OF BEHAVIOUR USING PHYSICO-CHEMICAL PROPERTIES.

“Optimizacion de proliferación y diferenciación celular in vitro=> aplicación en terapia transplante celular”