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CESAR ANTONIO RAMIREZ SARMIENTO

Assistant Professor

Pontificia Universidad Catolica de Chile

Santiago, Chile

Líneas de Investigación


Biophysics, evolution and function of gene-regulating metamorphic proteins (FoxP, RfaH, KaiB); enzyme discovery & engineering of novel biocatalysts for plastic degradation; development of open-source kits for molecular detection of SARS-CoV-2

Educación

  •  Molecular Biology, Cellular Biology and Neurosciences, UNIVERSIDAD DE CHILE. Chile, 2014
  •  Sciences with Honors in Biology, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Teaching in Higher Education, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2018

Experiencia Académica

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Institute for Biological and Medical Engineering

    Santiago, Chile

    2016 - A la fecha

  •   Researcher Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias

    Santiago, Chile

    2015 - 2016

  •   Postdoctoral Researcher Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias

    Santiago, Chile

    2013 - 2015

  •   Visiting Graduate Student Full Time

    UNIVERSITY OF CALIFORNIA-SAN DIEGO

    San Diego, Estados Unidos

    2011 - 2012

  •   Teaching Assistant Part Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias

    Santiago, Chile

    2007 - 2010

Experiencia Profesional

  •   Assistant Professor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2016 - A la fecha

  •   Scientific Advisor Other

    DICTUC S.A. & Ango Science SpA

    Santiago, Chile

    2017 - A la fecha

  •   Researcher Full Time

    Universidad de Chile

    Santiago, Chile

    2015 - 2016

  •   Postdoctoral Researcher Full Time

    Universidad de Chile

    Santiago, Chile

    2013 - 2015

  •   Grader for SIMCE Other

    INGEMAS LTDA

    Santiago, Chile

    2007 - 2007

  •   Grader's Supervisor for SIMCE Other

    INGEMAS LTDA

    Santiago, Chile

    2007 - 2007

Premios y Distinciones

  •   Hans Neurath Oustanding Promise Travel Award

    The Protein Society

    Estados Unidos, 2017

    The purpose of the awards is to showcase future protein science leaders--students and early-career protein scientists whose research has demonstrated exceptional potential--and to enable them to attend and present their abstracts at The Protein Society annual meeting

  •   Biophysical Society International Meeting Grant

    The Biophysical Society

    Chile, 2017

    The Society's International Relations Committee provides grants of up to $2500 to promote and facilitate the organization of and attendance at biophysical meetings and courses in countries experiencing financial need. Funds are provided for workshops and meetings organized by current Society members, which are held in countries in need or in nearby countries where organizers will use the funds to help students from countries in need attend the meeting. Granted for organizing the conference 2nd Protein Biophysics at the End of the World

  •   PABMB Funding 2017

    Panamerican Association for Biochemistry and Molecular Biology

    Canada, 2017

    PABMB support to Plenary Lectures and support to young scientists to attend scientific meetings, courses and workshops. Granted for organizing the conference 2nd Protein Biophysics at the End of the World

  •   PROLAB Fellowship 2016

    Panamerican Association for Biochemistry and Molecular Biology

    Chile, 2016

    Promoting Research Opportunities for Latin American Biochemists (PROLAB) Fellowship. Granted by the American Society for Biochemistry and Molecular Biology (ASBMB), the International Union of Biochemistry and Molecular Biology (IUBMB) and the Panamerican Association for Biochemistry and Molecular Biology (PABMB) for a short-term research visit to Ohio State University


 

Article (31)

Developing and Implementing Cloud-Based Tutorials That Combine Bioinformatics Software, Interactive Coding, and Visualization Exercises for Distance Learning on Structural Bioinformatics
An Evolutionary Marker of the Ribokinase Superfamily Is Responsible for Zinc-Mediated Regulation of Human Pyridoxal Kinase
Differential Local Stability Governs the Metamorphic Fold Switch of Bacterial Virulence Factor RfaH
Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping
PKD2/polycystin-2 induces autophagy by forming a complex with BECN1
Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma
Tuning of Conformational Dynamics Through Evolution-Based Design Modulates the Catalytic Adaptability of an Extremophilic Kinase
Polycystin-1 Assembles With Kv Channels to Govern Cardiomyocyte Repolarization and Contractility
Protein engineering of carotenoid cleavage dioxygenases to optimize beta-ionone biosynthesis in yeast cell factories
The protonation state of an evolutionarily conserved histidine modulates domainswapping stability of FoxP1.
Active Site Flexibility as a Hallmark for Efficient PET Degradation by I. sakaiensis PETase.
Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions.
Identifying the interactions between natural, non-caloric sweeteners and the human sweet receptor by molecular docking.
Protein topology determines substrate-binding mechanism in homologous enzymes.
Relevance of Local Flexibility Near the Active Site for Enzymatic Catalysis: Biochemical Characterization and Engineering of Cellulase Cel5A From Bacillus agaradherans
Riddle Me This: Substrate Channeling Solves the Paradigms of cAMP-Dependent Activation of PKA
Second ISCB Latin American Student Council Symposium (LA-SCS) 2016.
Unusual dimerization of a BcCsp mutant leads to reduced conformational dynamics
Discovery, Molecular Mechanisms, and Industrial Applications of Cold-Active Enzymes
Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer
Three-Dimensional Domain Swapping Changes the Folding Mechanism of the Forkhead Domain of FoxP1
Dissecting the functional roles of the conserved NXXE and HXE motifs of the ADP-dependent glucokinase from Thermococcus litoralis
Identifying Sequential Substrate Binding at the Single-Molecule Level by Enzyme Mechanical Stabilization
Interdomain Contacts Control Native State Switching of RfaH on a Dual-Funneled Landscape
The Folding Unit of Phosphofructokinase-2 as Defined by the Biophysical Properties of a Monomeric Mutant
Emergence of pyridoxal phosphorylation through a promiscuous ancestor during the evolution of hydroxymethyl pyrimidine kinases
A Ribokinase Family Conserved Monovalent Cation Binding Site Enhances the MgATP-induced Inhibition in E. coli Phosphofructokinase-2
Catalytic and regulatory roles of species involved in metal-nucleotide equilibriums in human pyridoxal kinase
Knotting pathways in proteins
Observation of Solvent Penetration during Cold Denaturation of E. coli Phosphofructokinase-2
Expanded Monomeric Intermediate upon Cold and Heat Unfolding of Phosphofructokinase-2 from Escherichia coli

Abstract (8)

Breaking Down Protein Metamorphosis: Primary Drivers Behind the Structural Transformation of the Bacterial Virulence Factor RfaH
Characterization of the domain swapping mechanism of the forkhead domain of human FoxP1 at a single-molecule level
Cold-Adapted ADP-Dependent Sugar Kinase: Biophysical and Evolutionary Study of its Flexibility.
Biophysical and evolutionary study of the structural flexibility of ADP-dependent sugar kinases from mesophilic and psychrophilic archaea
Elucidating the domain swapping mechanism of the forkhead domain of human FoxP1
Domain swapping of the DNA-binding domain of human FoxP1 is facilitated by its low folding stability
Folding topology determines substrate binding order in the ribokinase superfamily
Direct Observation Of Solvent Penetration During Cold Denaturation Of Pfk-2 By Amide Hydrogen/Deuterium (H/H-2) Exchange Mass Spectrometry

Proyecto (9)

Research and Training in Structural Genomics and Molecular Biophysics for the characterization and design of proteins and enzymes
Unveiling the evolutionary information for specifying a functional fold-switch in proteins
Biofisica e Ingenieria de Proteinas del Regulador del Reloj Circadiano KaiABC de Cianobacteria
Caracterización estructural, funcional e ingeniería de enzimas antárticas como potenciales biocatalizadores de la degradación de polietileno de tereftalato (PET)
International Cooperation Network for the start-up, installation and training of human capital in mass spectrometry for interdisciplinary research in Chile
BIOPHYSICAL AND EVOLUTIONARY ASSESSMENT OF THE EMERGENCE OF DOMAIN SWAPPING WITHIN THE FOX FAMILY OF TRANSCRIPTION FACTORS
Unveiling the potential PET-degrading activity of Antarctic cutinases via protein engineering
YEAST PLATFORMS FOR THE BIOTECHNOLOGICAL BIOSYNTHESIS OF APOCAROTENOID BIOACTIVE COMPOUNDS
BIOPHYSICAL CHARACTERIZATION OF STRUCTURAL REARRANGEMENTS DURING NATIVE STATE SWITCHING IN FKH1/FKH2 AND RFAH TRANSCRIPTION FACTORS
35
CESAR RAMIREZ

Assistant Professor

Institute for Biological and Medical Engineering

Pontificia Universidad Catolica de Chile

Santiago, Chile

8
Victoria Guixé

Titular Profesor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

7
Jorge Babul

UNIVERSIDAD DE CHILE

Santiago, Chile

5
Mauricio Baez

Assistant Professor

Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

5
Víctor Castro

Profesor Asistente

Departamento de Biología

UNIVERSIDAD DE CHILE

Ñuñoa, Chile

3
Ricardo Zamora

Ayudante Catedra

Universidad de las Americas

Santiago, Chile

2
Pablo Galaz

Estudiante de Doctorado

Escuela de Ingeniería

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Daniel Peña

Investigador postdoctoral

Departamento de Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

2
Exequiel Medina

Researcher

BIología

Universidad de Chile

Santiago, Chile

2
Christian Wilson

Associate professor

Bioquimica y Biologia Molecular

Universidad de Chile

Santiago, Chile

2
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

2
Jaime Rivas

Assistant Professor

Facultad de Ciencias

Universidad Mayor

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
loreto parra

Assitant Professor

Chemical and Bioprocesses Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

1
Vida Rodríguez

Investigadora Postdoctoral

Universidad de Chile

Santiago, Chile

1
Gabriel Vallejos

Investigador postdoctoral

Departamento de Biología

Universidad de Chile

Santiago, Chile

1
Ricardo Cabrera

Assitant Pofessor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Eduardo Agosin

Full Professor

Chemical and Bioprocess Engineering

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Javiera Reyes

Alumno Doctorado

Ingeniería

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Barbara Andrews

FULL PROFESSOR

CHEMICAL ENGINEERING AND BIOTECHNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile