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Vicente A Torres Gómez

Associate Professor

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Molecular mechanisms of cell migration; wound healing; cancer; intracellular trafficking; salivary peptides; histatins; small GTPases

Educación

  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2006
  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2001
  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Santiago, Chile

    2011 - 2016

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2010 - 2011

  •   Postdoctoral Fellow Full Time

    University of California San Diego

    UCSD Cancer Center

    La Jolla, California, Estados Unidos

    2006 - 2009

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Santiago, Chile

    2016 - A la fecha

Experiencia Profesional

  •   Academic Full Time

    Universidad de Chile

    Santiago, Chile

    2010 - A la fecha

  •   Postdoctoral Fellow Full Time

    University of California San Diego

    La Jolla, Estados Unidos

    2006 - 2009

  •   Postdoctoral Fellow Full Time

    Universidad de Chile - FONDAP CEMC

    Santiago, Chile

    2006 - 2006

Formación de Capital Humano


UNDERGRADUATE TEACHING:
Lecture professor at the courses “UTE Bases Científicas y Clínicas para el Diagnóstico”, “UTE Clínica del Adulto Mayor”, Faculty of Dentistry,
Universidad de Chile (years 2016-2021).
Lecture professor at the courses “Bases Celulares, Genéticas y del Desarrollo Ontogénico Humano”, “Curso de Biología”, “Fundamentos Científicos de la Medicina I”, Faculty of Medicine, Universidad de Chile (year 2010).
Lecture professor at the courses “Bioquímica General”, “Bioquímica Oral”, Faculty of Dentistry, Universidad de Chile (years 2011-2016).
Lecture professor at the courses “Química Fisiológica y Patológica Integrada”, “Biología Subcelular”, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile (years 2013-2016).

POSTGRADUATE TEACHING
1. “Farmacología Molecular y Avanzada”, PhD Program in Pharmacology, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile (year 2021).
2. “Cell Signaling in Biomedicine”, Programs of PhD in Biochemistry, PhD in Biomedical Sciences. Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile (years 2011-2021).
3. “Biología Celular y Molecular Avanzada”, Programs of PhD in Pharmacology, PhD in Neurosciences, PhD in Biomedical Sciences, PhD in Nutrition. Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile (years 2011-2021, responsible professor).
4. “Patología General”, Postgraduate School, Faculty of Dentistry, Universidad de Chile (year 2012).
5. “Principios de Bioquímica Humana”, Master in Dentistry, Postgraduate School, Faculty of Dentistry, Universidad de Chile (year 2012-2021).
6. “Biología Celular”, Postgraduate School, Faculty of Dentistry, Universidad de Chile (year 2012, 2014, 2017, 2019-2021).
7. "Topics in Biomedicine" PhD Program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile (year 2014-2016).

THESIS MENTORSHIP
PhD Thesis
Patricio Silva A: PhD in Biomedical Sciences, U Chile (2013-2016)
Jorge Díaz F: PhD in Biochemistry, U Chile, co-mentorship with Andrew Quest (2011-2015)
Andrea Arros V: PhD in Sciences, U Chile, co-mentorship with Verónica Palma (2014-2019)
Solange Rivas V.: PhD in Biomedical Sciences, U Chile (2015-2020)
Galdo Bustos: PhD in Biomedical Sciences, U Chile, co-mentorship with César Cárdenas (2017-2020)
Sebastián Venegas: PhD in Biomedical Sciences, U Chile (2017-2020)
Montserrat Reyes: PhD in Dental Sciences, U Chile (2015-2019)
Carlos Mateluna: PhD in Pharmacology, U Chile (2018-present)
Pedro Torres: PhD in Dental Sciences, U Chile (2021-present)
Tania Flores: PhD in Dental Sciences, U Chile (2021-present)
Daniela Herrera: PhD in Biomedical Sciences, U Chile (2021-present)

Undergraduate Thesis
Pedro Torres: Dentistry, U Chile (2017-2018)
Pablo Mendoza: Engineering in Molecular Biotechnology, U Chile (2011-2012)
Nicolás Soto: Biology, Pontificia Universidad Católica de Chile (2013)
Carolina Moraga: Engineering in Molecular Biotechnology, U Chile (2014-2015)
Diego Betancur: Dentistry, U Chile (2019-2021)

Master Thesis
Martial Millet: Pharmacy, Université Claude Bernard Lyon, Francia (2018)
Antoine Servanti: Engineering, U Chile (2017)

Teaching Administration
1. Coordinator of PhD course “Curso de Biología Celular y Molecular Avanzada”, Universidad de Chile.
2. Coordinator of undergraduate course “Oral Biochemistry”.
3. Participation in 7 PhD thesis committees per year (PhD in Biomedical Sciences and PhD in Biochemistry, Universidad de Chile).
4. Member of the PhD program in Biomedical Sciences.

OUTREACH
El Pulso de la Facultad de Medicina (year 2010).
http://www.med.uchile.cl/2010/octubre/4721-facultad-de-medicina-obtiene-seis-fondecyt-de-iniciacion.html
Diffusion lecture “Papel de la Proteína Endosomal Rab5 en la Migración y Metástasis de Células Tumorales”. Faculty of Dentistry, Universidad de Chile (year 2011).
Interview at the newspaper “El Mercurio”, in the context of the “61st Meeting of Nobel Laureates in Lindau”, Lindau, Alemania (year 2011). http://www.mer.cl/modulos/catalogo/Paginas/2011/06/30/MERSTCT012AA3006.htm
Diffusion lecture at “The Bayer News Channel”, BAYER Science and Education Fundation, Lindau, Alemania (year 2011).
http://www.bnc.bayer.de/bayer/bnci.nsf/id/0CD17DAEE2260079C12578C700312BCD?open&ccm=010010
Summer school “Bioquímica de los Microorganismos”, Faculty of Dentistry, Universidad de Chile (year 2012).


Premios y Distinciones

  •   Programa Ciencia de Frontera

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2012

    The program "Ciencia de Frontera" is organized be the Chilean Academy of Sciences, and recognizes the excellence and potential of young scientists in different areas of sciences. There is a formal interaction with the activities of the Chilean Academy of Sciences. This is the 4th version of this program and it lasts 3 years.

  •   Best Presentation

    Chilean Society for Cell Biology

    Chile, 2012

    Best Presentation PhD student Jorge Díaz XXVI Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, Chile.

  •   Best Presentation

    Chilean Society for Cell Biology

    Chile, 2012

    Best Presentation Undergraduate student Pablo Mendoza XXVI Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, Chile.

  •   Best Presentation

    Chilean Society for Cell Biology

    Chile, 2011

    Best Presentation PhD student Jorge Díaz XXV Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas, Chile.

  •   Editorial Adviser

    Biochemical Journal

    Estados Unidos, 2014

    Invited to form part of the Editorial Adviser Board, in order to participate in editorial duties and peer reviewing process for this journal.

  •   Best PhD Thesis

    Fundación Allende-Conelly

    Chile, 2016

    Distinction made to the PhD Student Jorge Diaz, supervised by Vicente Torres

  •   Premio Federico Leighton a la Mejor Tesis de Pregrado o Magister

    Fundación Chilena para la Biología Celular y Sociedad de Biología Celular de Chile

    Chile, 2018

    Premio asignado al estudiante de pregrado Pedro Torres Salazar, estudiante tesista para otener el Título de Cirujano Dentista. Director de Tesis: Vicente Torres


 

Article (46)

Histatin-1 is a novel osteogenic factor that promotes bone cell adhesion, migration, and differentiation
The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-beta 1 and focal adhesion kinase activation
Nuclear accumulation of ?-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia
Nuclear accumulation of β-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia
PKD2/polycystin-2 induces autophagy by forming a complex with BECN1
Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma
The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis
The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells
Wnt/beta-Catenin Signaling in Oral Carcinogenesis
Focal adhesion kinase-dependent activation of the early endocytic protein Rab5 is associated with cell migration
Histatin-1 counteracts the cytotoxic and antimigratory effects of zoledronic acid in endothelial and osteoblast-like cells
Nuclear localization of beta-catenin and expression of target genes are associated with increased Wnt secretion in oral dysplasia
Role of glycosylation in hypoxia-driven cell migration and invasion
Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration
Hypoxia-induced caveolin-1 expression promotes migration and invasion of tumor cells
The Netrin-4/Laminin ?1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells
Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells
Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression
The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration
The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis
Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation
A novel caveolin-1/p85?/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
Molecular mechanisms implicated in Caveolin 1 dependent Rab5 activation, migration and invasion of metastatic cancer cells
On the Role of Rab5 in Cell Migration
Rab'ing tumor cell migration and invasion Focal adhesion disassembly driven by Rab5
Rab5 activation as a tumor cell migration switch
Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion
E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells
Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells
The Caveolin-1 Connection to Cell Death and Survival
Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells
Age-Dependent Increases in Apoptosis/Necrosis Ratios in Human Lymphocytes Exposed to Oxidative Stress
Rab5 mediates caspase-8 promoted cell motility and metastasis
Caspase-8 association with the focal adhesion complex promotes neuroblastoma migration and metastasis
Caveolin-1-mediated Suppression of Cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent Transcriptional Mechanism Reduced Prostaglandin E-2 Production and Survivin Expression
Paclitaxel promotes a caspase-8-mediated apoptosis through death effector domain association with microtubules
The death effector domains of caspase-8 induce differentiation and senescence
Caspase-8 promotes peripheral localization and activation of Rab5
Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells
The marine lipopeptide somocystanimide A triggers apoptosis via caspase-8
E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-Catenin-Tcf/Lef-dependent transcription
Casein kinase 2 (CK2) increases survivin expression via enhanced ?-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription
Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin
Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase

Abstract (1)

Caspase-dependent necrosis-like cell death downstream of the Fas receptor is associated with lipid scrambling and delayed ceramide increase in lymphoid cells

BookReview (1)

Caveolin-1 in colon cancer: the flexible connection to Wnt signaling

EditorialMaterial (1)

Signaling in Cell Migration and Disease

Patent (1)

HISTATIN-1 FORMULATION FOR THE TREATMENT, REPAIR OR REGENERATION OF BONE TISSUE IN A SUBJECT

Proyecto (7)

FONDECYT 1180495 "Dissecting the mechanisms whereby hypoxia leads to Rab5 activation, epithelial to mesenchymal transition and cancer cell migration"
CONICYT Insertion of Young Researchers in the Academy #79090021
FONDAP 15130011 "Advanced Center for Chronic Diseases"
FONDECYT 11100287 "ROLE OF RAB5 IN CELL MIGRATION AND METASTASIS"
FONDECYT 1110189 "INVERSE ASSOCIATION BETWEEN CANCER AND ALZHEIMER DISEASE: IN SEARCH OF COMMON BIOLOGICAL MECHANISMS"
FONDECYT 1130250 "CAVEOLIN-1-DEPENDENT MIGRATION AND METASTASIS OF CANCER CELLS REQUIRES TYR14 PHOSPHORYLATION, SEQUESTRATION OF P85A AND ACTIVATION OF THE RAB5-RAC1 PATHWAY, WHICH ARE INHIBITED BY EXPRESSION OF E-CADHERIN"
FONDECYT 1140907 "ELUCIDATION OF THE MECHANISMS UNDERLYING RAB5 MEDIATED FOCAL ADHESION DISASSEMBLY, CANCER CELL MIGRATION AND INVASION"

Review (4)

Histatins, wound healing, and cell migration
Rab5 in the Regulation of Cell Motility and Invasion
Caveolin-1: an ambiguous partner in cell signalling and cancer
Beyond apoptosis: Nonapoptotic cell death in physiology and disease
66
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

13
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

9
Patricio Silva

Investigados Postdoctoral

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

7
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

6
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

5
Daniel Peña

Investigador postdoctoral

Departamento de Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Pedro Torres

Ayudante laboratorio

Universidad de Chile

Santiago, Chile

3
Verónica Palma

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

3
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

2
CESAR RAMIREZ

Assistant Professor

Institute for Biological and Medical Engineering

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Hery Urra

Postdoctorado

UNIVERSIDAD DE CHILE

Santiago, Chile

2
JUAN VILLENA

ASSOCIATE PROFESSOR

BIOMEDICAL SICIENCES

FACULTA DE MEDICINA. UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

2
Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

2
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

2
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Luis Cordova

Academico

Universidad de Chile

Santiago , Chile

2
Maria Diaz

Part time Professor

Ciencias Quimicas y Biologicas

Universidad Bernado O´higgins

Santiago , Chile

1
Rina Ortiz

Profesora investigadora

Física

Universidad Técnica Federico Santa María

Valparaiso, Chile

1
Patricia Fuenzalida

Lab Manager

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
IVAN GALLEGOS

PATHOLOGIST, LABORATORY DIRECTOR

PATHOLOGY

HOSPITAL CLINICO DE UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Eugenia Diaz

Profesor Asistente

Facultad de Medicina

Universidad de Chile

Santiago, Chile

1
Pablo Lois

Asistente de Investigación

Biología

Universidad de Chile

Santiago, Chile

1
RENAN ORELLANA

Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Rafaela Erices

Postdoctorante

Ginecología y Obstetricia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

1
Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
LORENA AGUILAR

Assistant Professor

Animal Pathology

Faculty of Veterinary Medicine and Livestock Sciences, University of Chile

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Hachi Manzur

Neurólogo de Adultos

Red de Salud UC Christus

Santiago, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
Natalia Diaz

Postdoctoral Fellow

Biofísica y Bioingeniería

Universidad de Barcelona

Barcelona , España

1
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Andrea Maturana

Academico

Patologia y Medicina Oral

Facultad de Odontologia

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mónica Silva

Lab Manager

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

1
Ana Rojas

Asistente de Investigación

Universidad Autónoma de Chile

Santiago, Chile

1
Margarita Montoya

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

1
Mario Párraga

JEFE DE LABORATORIO

ANATOMÍA

UNIVERSIDAD DE VALPARAÍSO

Reñaca, Chile

1
Bárbara Casas

Estudiante PhD

Biología

Universidad de Chile

Santiago, Chile

1
Christopher Fitzpatrick

Postoctoral Researcher

Non coding RNAs

Fundación Ciencia y Vida

Santiago, Chile