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Steffen Härtel Gründler

Full Professor

University of Chile

Santiago, Chile

Líneas de Investigación


Scientific Imaging and Microscopy; Computational Medicine; Cellular Biology; Image Processing; Membrane Biophysics, Medical Informatics

Educación

  •  Diploma in Physics, UNIVERSITAT BREMEN. Alemania, 1996
  •  Dr rer nat Physics, UNIVERSITAT BREMEN. Alemania, 2000

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2006 - 2011

  •   Associated Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2012 - 2017

  •   Full Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Postdoc Full Time

    Bremen Universitat

    Bremen, Alemania

    2000 - 2000

  •   Postdoc / Automatic Video-Analysis And Textual Annotation (Avanta) Full Time

    Center For Computing Technologies (Tzi) / Dfg- Schwerpunkt-Program

    Bremen, Alemania

    2001 - 2001

  •   Postdoc / Structure, Dynamics And Kinetics In Biomembranes And Necrobiological Processes Focussed Full Time

    Universidad de Córdoba / Alexander Von Humboldt Foundation

    Córdoba, Argentina

    2001 - 2003

  •   Postdoc / Mechanisms Of Apoptotic And Necrotic Cell Death: Time Resolved Multi-Parameter Analysis Full Time

    Centro De Estudios Cientificos (CECS) and Universidad Austral de Chile

    Valdivia, Chile

    2003 - 2006

  •   Subdirector of Research, Instituto de Ciencias Biomedicas, Facultad de Medicina Other

    Universidad de Chile

    Santiago, Chile

    2015 - A la fecha

  •   Director of Center of Medical Informatics and Telemedicine, CIMT, Faculty of Medicine Full Time

    Universidad de Chile

    Santiago, Chile

    2016 - A la fecha

  •   Director, National Center for Health Information Systems, CENS, CTTS-66390 Part Time

    CORFO

    Santiago, Chile

    2017 - A la fecha

Formación de Capital Humano


Post-doctoral Sponsor (4)
===============
1.- 2013-2016. Victor Castañeda, post-doctoral FONDECYT 3140444 "Particle filter based tracking and segmentation pipeline for the analysis of cell shape in large biomedical imaging data".
2.- 2013-2016. Mauricio Cerda, post-doctoral FONDECYT 3140447 "Structural and dynamical priors for the characterization of tubular networks in cell biology".
3.- 2012-2015, German Reig, post-doctoral FONDECYT 3130598 "Papel de la adhesión diferencial y la inhibición por contacto de locomoción celular como motores de la expansión tisular en la epibolia de peces teleósteos".
4.- 2010-2013. Omar Ramírez, post-doctoral FONDECYT 3110157 "Structure and Dynamics of the Endoplasmic Reticulum: Molecular Mechanisms at the Interface of Form and Function".

Phd Tutor / Co-tutor (9)
===============
1.- 2013, PhD co-tutor, Alex Cordova, F-Med, U-Chile
2.- 2013, PhD co-tutor, Jorge Toledo, F-Med, U-Chile
3.- 2013, PhD co-tutor, Sandra de la Fuente, Public Health School, F-Med, U-Chile.
4.- 2012, PhD co-tutor, Violeta Chang, Characterization of Human Sperm Components for an Accurate Morphological Analysis. Departamento de Ciencias de la Computación. In progress.
5.- 2012, PhD co-tutor, Raquel Pezoa , A segmentation method for images with subjective contours in the field of digital pathology. Universidad Técnica Federico Santa María. In progress.
6.- 2010, PhD co-tutor, Rodrigo Rojas, Image segmentation constrained to topological invariants for digital pathology and medical imaging. Universidad Técnica Federico Santa Mária. In progress.
7.- 2009-2010, PhD co-tutor, Pablo Aguilar, Departamento de Ciencias de la Computación, U-Chile.
8.- 2009, PhD co-tutor, Jorge Jara, "Superficies Activas y Conceptos de Vecindades Tridimensionales para la Cuantificación y Parametrización de Fenómenos de Compactación en Estructuras Biológicas", Departamento de Ciencias de la Computación, Universidad de Chile. In process.
9.- 2009-2011, PhD co-tutor, José del Piano, Departamento de Ingeniería Electrica, U-Chile.

Summer Schools & short courses (>10)
===============
1.- 2014, F-Med, U-Chile, Summer School Optics, Forces & Development, organizer and lectures.
2.- 2014, F-Med, U-Chile, first BioMed-HPC collaboration network meeting.
3.- 2013, F-Med, U-Chile and DAAD, "Diplomado en Informatica Medica, Sistemas de Información en Salud: Requisitos para un Diseño e Implementación Exitoso"
4.- 2013, Instituto Clemente Estable, Montevideo, Uruguay, The Microbial World through different eyes.
5.- 2013, F-Med, U-Chile and DAAD, Summer School Computational Bio-Medicine, organizer and lectures.
6.- 2013, F-Med, U-Chile, Summer School Optics, Forces & Development, organizer and lectures.
7.- 2011, F-Med, U-Chile and DAAD, "Diplomado en Informatica Medica, Sistemas de Información en Salud: Requisitos para un Diseño e Implementación Exitoso".
8.- 2010, Instituto Clemente Estable, Montevideo, Uruguay, "MICROSCOPÍA DE FLUORESCENCIA."
9.- 2005, Universidad de la República, Montevideo, Uruguay, "DECONVOLUCION Y RECONSTRUCCIÓN DE ESTRUCTURAS 10.- 2003, DIMENSIONALES EN LA MICROSCOPIA CONFOCAL."

See a detailed list of other short lectures (from 2006-2014) at http://www.scian.cl/portal/globals.php?COD_SECCION=2960

Research units (5)
===============
1.- 2012, responsible of Alex Cordova research units course, Ciencias Biomédicas Phd Program, F-Med, U-Chile.
2.- 2009, with Dr. Miguel Concha, responsable of Germán Reig research units course, Ciencias Biomédicas Phd Program, F-Med, U-Chile.
3.- 2009, with Dr. Miguel Concha, responsable of Eduardo Pulgar research units course, Ciencias Biomédicas Phd Program, F-Med, U-Chile. "Campos de especialización procesos migratorios y las transformaciones de la organogénesis células precursoras dorsal".
4.- 2008, with Dr. Miguel Concha, responsable of Germán Reig research units course, Ciencias Biomédicas Phd Program, F-Med, U-Chile. "Campos de especialización son la biología del pez cebra, de desarrollo, la morfogénesis y la proyección de imagen confocal de 4D."
5.- 2007, with Dr. Miguel Concha, responsable of Karina Palma research units course Biological Sciences Master program, F-Med, U-Chile. "Análisis Morfo -Topológico de la Migración Asimétrica del Órgano Parapineal en el Desarrollo Embrionario de Pez Cebra (Danio rerio)".

Master level (5)
===============
1.- 2014. Images and bio-signals processing I & II. Responsible Professor. Medical Informatics Program, F-Med, U-Chile.
2.- 2014. Bibliographic seminar course. Responsible Professor. Medical Informatics Program, F-Med, U-Chile.
3.- 2012. Images and bio-signals processing I & II. Responsible Professor. Medical Informatics Program, F-Med, U-Chile.
4.- 2012. Bibliographic seminar course. Responsible Professor. Medical Informatics Program, F-Med, U-Chile.
5.- 2012-2014. Coordinator of the Medical Informatics Program, F-Med, U-Chile.

Undergraduate (10)
===============
1.- 2014, responsible of Computer Engineer thesis, Iván Rojas. Department of Computer Science (DCC), FCFM, U-Chile. "Optimización y paralización de un algoritmo de generación de skeletons".
2.- 2012, responsible of Computer Engineer thesis, Liliana Alcayaga Gallardo. DCC, FCFM, U-Chile. "Esqueletonización de estructuras biológicas tridimensionales."
3.- 2008, responsible of Mathematical Engineer thesis, Luis Felipe Olmos Marchant, Department of Mathematics, FCFM, U-Chile. ’Conceptos de Vecindades Tridimensionales para la Cuantificación y Parametrización de Fenómenos de Compactación en Estructuras Biológicas.’
4.- 2006, responsible of Computer Engineer thesis, Jorge Francisco Jara Wilde, Escuela de Ingeniería Civil en Informática (EICI), Universidad Austral de Chile (U-Austral). "Contornos activos y su aplicación para la segmentación y parametrización tridimensional de estructuras biológicas."
5.- 2005, responsible of Computer Engineer thesis, Etiene Valentino Verdugo Ruiz, EICI, U-Austral. "Reconstrucción, visualización y parametrización tridimensional de estructuras biológicas a través de imágenes confocales de fluorescencia."
6.- 2003, responsible of Computer Engineer thesis María Luisa Oyarzo Vergara, Physics Department (PD) and EICI, U-Austral "Segmentación y análisis automatizado de objetos en movimiento aplicado al estudio microscópico de sistemas biológicos en tiempo real."
7.- 2001, collaborator of Computer Engineer thesis, Pamela Barria PD & EICI, U-Austral. "Plataforma de Identificación, Clasificación y Análisis de Imágenes, obtenidas a partir de muestras Celulares."
8.- 2001, collaborator of Computer Engineer thesis, Victor Espinoza Romero, PD & EICI, U-Austral. "Plataforma de Identificación, Clasificación y Análisis de Imágenes, obtenidas a partir de muestras Celulares."
9.- 2001, collaborator of Computer Engineer thesis Rodrigo Rojas Moraleda, PD & EICI, U-Austral. "Plataforma de Identificación, Clasificación y Análisis de Imágenes, obtenidas a partir de muestras Celulares."
10.- 2000, Tutor for the diploma thesis in experimental physics, Mr. Marcus Haas, University of Bremen: "Charakterisierung der Fluoreszenzeigenschaften des Farbstoffs DiI-CN in Zusammenhang mit der Bestimmung von physikalischen Zuständen in Lipidmembranen".


Premios y Distinciones

  •   Academic Excellence in Research Medal

    University of Chile

    Chile, 2013

    Special distinction for academic excellence in research at F-Med, U-Chile.

  •   Iberoamerican award to innovation and entrepreneurship (SEGIB)

    Secretaria General Iberoamericana

    España, 2012

    The Iberoamerican awards for Innovation and entrepreneurship are awarded to projects technology, products and services,

  •   Academic Excellence in Research Medal

    University of Chile

    Chile, 2012

    Medalla a la excelencia académica otorgada por autoridad maxima de la facultad de medicina de la universidad de chile

  •   Innovative Vision award 100K 2011

    Banco Santander - Universia

    Chile, 2011

    seed capital award for technological innovations projects.

  •   Digital Thesis of the Year

    UNIVERSIA (www.universia.cl) and Fundación Pais Digital, Chile and Fundación Pais Digital, Chile

    Chile, 2007

    Supervisor of the Diploma Thesis.

  •   Doctor José Tohá Castella

    EXPLORA of the Comisión Nacional de Investigación Científica y Technológica, CONICYT

    Chile, 2005

    Recognition for outstanding divulgation of science and technology activities.

  •   Feodor Lynen Fellowship

    Alexander von Humboldt Foundation

    Alemania, 2001

    Feodor Lynen Fellowship.

  •   Special award for the Ph.D. thesis

    Bruker Daltonik GmbH

    Chile, 2000

    Special award for the Ph.D. thesis

  •   Bremer Studienpreis for the best Ph.D. thesis in natural sciences of the year

    University of Bremen

    Chile, 2000

    the best Ph.D. thesis in natural sciences of the year

  •   Dissertation passed with Maximum Distinction summa cum laude

    University of Chile

    Chile, 2000

    summa cum laude

  •   Travel & Investigation Grant, DAAD

    German Foreign Academic Exchange Agency

    Chile, 1997

    Travel & Investigation Grant, DAAD.

  •   Bremer Studienfonds e.V, Investigation Fellowship & Travel Fellowship, DAAD

    German Foreign Academic Exchange Agency

    Chile, 1995

    to perform research at the Instituto de Física, Universidad Austral de Chile, Valdivia, Chile

  •   Recognition for its Contribution to Research under the ISI-WOS 2017 Publication, entitled "Extra-Embryonic tissue spreading direct early embryo morphogenesis in killifish"

    UNIVERSIDAD DE CHILE

    Chile, 2018

    Located in the top 6% of its discipline. Published in the journal Nature Communications

  •   Recognition for its Contribution to Research under the Publication ISI-WOS 2017, entitled "Epigenetic editing of th Dlg4 / PSD95 gene improves cognition in aged and Alzheimer's disease mice"

    UNIVERSIDAD DE CHILE

    Chile, 2018

    Located in the top 6% of its discipline. published in the journal Brain.

  •   Recognition for its Contribution to Research under the Publication ISI-WOS 2017, entitled "Directional asymmetry in the volume of the human habenula"

    UNIVERSIDAD DE CHILE

    Chile, 2018

    Located in the top 6% of its discipline. Published in the journal Brain Structure & Function

  •   Recognition for its Contribution to Research under the Publication ISI-WOS 2017, "Extra-embryonic tissue spreading direct early embryo morphogenesis in killifish"

    UNIVERSIDAD DE CHILE

    Chile, 2018

    Located in the top 6% of its discipline. Published in the journal Nature Communications.

  •   Recognition for its Contribution to Research under the award of the Fondecyt-Regular 2018 project, entitled "5D Image Processing and Physical Models for the Quantification of Cell Migration and Multicellular Architecture with 4-Lens Light Sheet Fluorescen

    UNIVERSIDAD DE CHILE

    Chile, 2018

    Evaluation in the top 10% of the Engineering study group 2.

  •   Special recognition for its contribution to the value that university internalization must play in the development of the University of Chile and the country

    UNIVERSIDAD DE CHILE

    Chile, 2018

    Recognition for their work in promoting and specifying internationalization activities.


 

Article (68)

dSTORM microscopy evidences in HeLa cells clustered and scattered H2AX nanofoci sensitive to ATM, DNA-PK, and ATR kinase inhibitors
dSTORM microscopy evidences in HeLa cells clustered and scattered γH2AX nanofoci sensitive to ATM, DNA-PK, and ATR kinase inhibitors
Evaluating Online Consumer Medication Information Systems: Comparative Online Usability Study
Mathematical Modeling for 2D Light--Sheet Fluorescence Microscopy image reconstruction
Mathematical modeling for 2D light-sheet fluorescence microscopy image reconstruction
Optimising adjacent membrane segmentation and parameterisation in multicellular aggregates by piecewise active contours
Chronic Fluoxetine Treatment Induces Maturation-Compatible Changes in the Dendritic Arbor and in Synaptic Responses in the Auditory Cortex
The Role of Mitochondria in Calcium Signaling and Human Sperm Physiology Activated by Progesterone
Variable numbers of calreticulin genes in Trypanosoma cruzi correlate with atypical morphology and protein expression
Asymmetric morphogenesis of the parapineal organ in the embryonic zebrafish brain
Automatic classification of human sperm head morphology
CDK5 downregulation enhances synaptic plasticity
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish
Gastrulation in an annual killifish: Molecular and cellular events during germ layer formation in Austrolebias
Gold-standard for computer-assisted morphological sperm analysis
Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons
Light/dark cycles modulate asymmetric parapineal connectivity to the left habenula in zebrafish larvae
RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid beta Peptide Oligomers
Sleep/wake disorders and the hypocretin/orexin system in a zebrafish model of Parkinson's Disease
A frame-based ANN for classification of hyperspectral images: assessment of mechanical damage in mushrooms
Directional Asymmetry in the Volume of the Human Habenula
Fimbriae have distinguishable roles in Proteus mirabilis biofilm formation
Leader Cells Define Directionality of Trunk, but Not Cranial, Neural Crest Cell Migration
Segmentation of HER2 protein overexpression in immunohistochemically stained breast cancer images using Support Vector Machines
An Implementation of Combined Local-Global Optical Flow
Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma
Transactivation activity and nucleocytoplasmic transport of beta-catenin are independently regulated by its C-terminal end
Trypanosoma cruzi Calreticulin Topographical Variations in Parasites Infecting Murine Macrophages
Trypanosoma cruzi infectivity assessment in "in vitro" culture systems by automated cell counting
Bleomycin-induced gamma H2AX foci map preferentially to replicating domains in CHO9 interphase nuclei
Computational Methods for Analysis of Dynamic Events in Cell Migration
Gold-standard and improved framework for sperm head segmentation
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons
Spermatozoa from mice deficient in Niemann- Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability
Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth
A method for analysis of lipid vesicle domain structure from confocal image data
Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells
TRP, TRPL and Cacophony Channels Mediate Ca2+ Influx and Exocytosis in Photoreceptors Axons in Drosophila
Association of age with sperm DNA fragmentation
Aumento del daño en el ADN espermático en varones mayores de 40 años
Changes in Rab3D Expression and Distribution in the Acini of Sjogren's Syndrome Patients Are Associated With Loss of Cell Polarity and Secretory Dysfunction
Development of 3D architecture of uropathogenic Proteus mirabilis batch culture biofilms-A quantitative confocal microscopy approach
High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-kappa B Activity
Location matters: the endoplasmic reticulum and protein trafficking in dendrites
Microtubule-associated Protein 1B (MAP1B) Is Required for Dendritic Spine Development and Synaptic Maturation
Performance of optical flow techniques for motion analysis of fluorescent point signals in confocal microscopy
Confined displacement algorithm determines true and random colocalization in fluorescence microscopy
Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ
Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopy
Dendritic Assembly of Heteromeric gamma-Aminobutyric Acid Type B Receptor Subunits in Hippocampal Neurons
Insulin Resistant Skeletal Muscle: Mitochondria Structure, Dynamics and Calcium Homeostasis
Lipid domains in giant unilamellar vesicles and their correspondence with equilibrium thermodynamic phases: A quantitative fluorescence microscopy imaging approach
NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells
Sphingomyelinase-Induced Domain Shape Relaxation Driven by Out-of-Equilibrium Changes of Composition
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible robe in cardioprotection
Marlin-1 and conventional kinesin link GABA(B) receptors to the cytoskeleton and regulate receptor transport
The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers
ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload
Surface-bound phosphatase activity in ectomycorrhizal fungi: a comparative study between a colorimetric and a microscope-based method
Anatomical-physiological determination of surface bound phosphatase activity in ectomycorrhizae of Nothofagus obliqua
Shape transitions and lattice structuring of ceramide-enriched domains generated by sphingomyelinase in lipid monolayers
Surface-bound phosphatase activity in living hyphae of ectomycorrhizal fungi of Nothofagus obliqua
Ultraviolet exposure of thymocytes: selective inhibition of apoptosis
NEW PERSPECTIVES ON THE DETERMINATION OF PHOSPHATASE ACTIVITY IN ECTOMYCORRHIZAE OF NOTHOFAGUS OBLIQUA FORESTS IN SOUTHERN CHILE
Staurosporine-induced apoptosis in human cornea epithelial cells in vitro
The susceptibility of non-UV fluorescent membrane dyes to dynamical properties of lipid membranes

Proyecto (39)

Capacitaciones en Biofilm: una respuesta para superar las bacterias multi-resistentes
Deep-Pathology: Plataforma de TelePatología Distribuida Basada en Blockchain y Diagnóstico Colaborativo Apoyado por Deep Learning
5D Image Processing and Physical Models for the Quantification of Cell Migration and Multicellular Architecture with 4-Lens Light Sheet Fluorescence Microscopy
CENS=> Centro Nacional en Sistemas de Información en Salud.
CHIP=> Chilean Health Info and Process Challenge
Diseño de un modelo de información, conceptual y semántico, para caracterizar los prestadores de salud en Chile
Millennium Science Institute Biomedical Neuroscience Institute
THE INSTRUCTIVE ROLE OF NODAL SIGNALLING IN ASYMMETRIC BRAIN MORPHOGENESIS OF ZEBRAFISH
Desarrollo de metodología para generación de gold-standards biomédicos para patología digital usando aprendizaje supervisado basado en múltiples expertos
El órgano parapineal (Opp) como modulador de la actividad del núcleo habenular izquierdo (iHab)=> Respuesta funcional de la actividad fotosensora del Opp sobre las neuronas iHab en larva de pez cebra (Danio rerio).
Estudio del papel de la proteina estructural nuclear especifica de la meiosis (MNS1) en la tranmission de fuerzas que generan la motilidad ciliar en pez zebra
Image Processing and Physical Models for the Interpretation of Cell Migration with 4-Lens Light Sheet Fluorescence Microscopy
Reproducible Research in Image and Signal Processing (ReRISiP) Arg/Chile/Uy/Brazil/France
Terminología Farmacéutica Chilena, condición habilitante para receta electrónica y otros sistemas de información en el sector salud
Visualización y Manipulación de Señales y Fuerzas en Tejidos en Desarrollo
Sistema de Almacenamiento y Servicios Informáticos Biomédicos Avanzados (SASIBA)
BioMedHPC=> Red de Biología y Medicina Computacional de Alto Rendimiento. Facultad de Medicina, Facultad de Odontología, U-Chile
Initiative for Big-Data-Management, Processing, and Distribution for Science and Education in R&D
Particle filter based tracking and segmentation pipeline for the analysis of cell shape in large biomedical imaging data.
STRUCTURAL AND DYNAMICAL PRIORS FOR THE CHARACTERIZATION OF TUBULAR NETWORKS IN CELL BIOLOGY.
"Molecular Profiling of Stage II and III Breast Cancer in Latin American Women receiving Standard of Care Treatment"
Centro de Patología Digital Asistida por Internet
Fast Computational Schemes for the Analysis of Morpho-Topological Data from High Throughput Microscopy
PAPEL DE LA ADHESION DIFERENCIAL Y LA INHIBICION POR CONTACTO DE LOCOMOCION CELULAR COMO MOTORES DE LA EXPANSION TISULAR EN LA EPIBOLIA DE PECES TELEOSTEOS.
THE ROLE OF EPIBOLY AND CHEMOKINE SIGNALLING IN THE DETERMINATION OF ANTERIOR-POSTERIOR POLARITY IN THE KUPFFERS'S VESICLE OF ZEBRAFISH
Image Processing Online Latin America=> IPOL_LA
Role of Notch signalling during neural crest migration
Scientific Network Göttingen Biophysics & Complex System Group.
STRUCTURE AND DYNAMICS OF THE ENDOPLASMIC RETICULUM=> MOLECULAR MECHANISMS AT THE INTERFACE OF FORM AND FUNCTION
Development, Evolution and Interplay of Brain Asymmetries in Teleosts
Espermiogramas Digitales Asistidos Por Internet (ED•AI)
EXZELLENZZENTRUM SANTIAGO DE CHILE - HEIDELBERG
NUCLEUS OF NEURAL MORPHOGENESIS (NEMO) Millennium Science Nuclei
PARTIAL DIFFERENTIAL EQUATIONS FOR 3D PHOTON DENOISING, OPTICAL FLOW AND ADJACENT ACTIVE SURFACE MODELS FOR HIGH THROUGHPUT IN VIVO SPINNING DISK MICROSCOPY
Biological Imaging Network for in vivo Analysis of Gene Function during Development
Marlin-1 Y Receptores Inhibitorios GABAB en Sinapsis Centrales
DEVELOPMENT AND APPLICATION OF SCALING INDEX METHODS FOR THE AUTOMATED QUANTIFICATION OF COLOCALIZATION IN FLUORESCENCE MICROSCOPY.
Scaling Index Methods for the Automated Quantification of Colocalization in Fluorescence Microscopy
MECHANISMS OF APOPTOTIC AND NECROTIC CELL DEATH=> TIME RESOLVED MULTI-PARAMETER ANALYSIS OF MEMBRANE RELATED PROCESSES

Article (17)

Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway.
CDK5 downregulation enhances synaptic plasticity.
Translational cancer research comes of age in Latin America
Ciencia Computacional Aplicada a la Biomedicina
Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport
The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers
Phosphatase Activity in Ectomycorrhiza Fungi: A Comparative Study Between a Colorimetric and a Microscope-Based Method
Anatomical-physiological determination of surface bound phosphatase activity in ectomycorrhiza of Nothofagus obliqua based on image processed confocal fluorescence microscopy
Di- and triploid erythrocyte identification by multi-parameter image analysis=> A new method for the quantification of triploidization rates in rainbow trout (Oncorhynchus mykiss)
Surface bound phosphatase activity in living hyphae of ectomycorrhizal fungi of Nothofagus obliqua
Ceramide modulates the lipid membrane organization at molecular and supramolecular levels
New Perspectives in the Determination of phoshatase activity in ectomycorrhiza of Nothofagus obliqua in forests of southern Chile
Bidirectional Control of Sphingomyelinase Activity and Surface Topography in Lipid Monolayers
Kinetics of apoptotic markers in exogeneously induced apoptosis of EL4 cells
Carotenoids in 1,2-dipalmitoyl-sn-glycero-3-phosphoryl-choline liposomes: incorporation and effects on phase transition and vesicle size.
Cholesterol induced variations of membrane dynamics related to the induction of apoptosis in mouse thymocytes
Methyl-beta-cyclodextrins and liposomes as water-soluble carriers for cholesterol incorporation into membranes and its evaluation by a microenzymatic fluorescence assay and membrane fluidity-sensitive dyes

Abstract (8)

Physical Model of Collective Cell Migration in Zebrafish Gastrulation
Microtubule-associated protein 1B (MAP1B) regulates synaptic functions in mature neurons
TRYPANOSOMA CRUZI INDUCES CELLULAR PROLIFERATION IN THE TROPHOBLASTIC CELL LINE BEWO
TRYPANOSOMA CRUZI INDUCES DIFFERENTIATION OF THE TROPHOBLAST
Comparative analysis of epiboly in teleost fish
Linking organ formation to left-right patterning in the embryonic zebrafish
Wnt11/Pk1a-mediated planar cell polarity signalling orchestrates epithelial organ morphogenesis by regulating N-cadherin dependent cell adhesion forces
Asymmetric morphogenesis of the parapineal organ in the developing zebrafish brain

ConferencePaper (2)

SOFI of GABAB neurotransmitter receptors in hippocampal neurons elucidates intracellular receptor trafficking and assembly
3D morpho-topological analysis of asymmetric neuronal morphogenesis in developing zebrafish

Review (1)

The action of sphingomyelinase in lipid monolayers as revealed by microscopic image analysis

BookSection (1)

Zebrafish Neural Crest: Lessons and Tools to Study In Vivo Cell Migration

Monograph (1)

Ciencia Computacional Aplicada a la Biomedicina
93
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

8
Jorge Jara

PhD student

UNIVERSIDAD DE CHILE

Chile

8
Mauricio Cerda

Assistant Professor (appointed)

Programa de Anatomía y Biología del Desarrollo

UNIVERSIDAD DE CHILE

Santiago, Chile

7
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

7
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Nancy Hitschfeld

Associate Professor

Computer Science

UNIVERSIDAD DE CHILE , DEPTO CIENCIAS COMPUTACION

Santiago, Chile

4
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

4
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

3
Violeta Chang

Profesora asistente

Ingeniería Informática

Universidad de Santiago de Chile

Santiago, Chile

3
Karina Palma

Postdoctorado

Instituto de Neurociencia Biomédica BNI

Universidad de Chile

Santiago, Chile

3
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

3
Eduardo Pulgar

Postdoctorado

Departamento de Anatomía y Biología del Desarrollo

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

3
Victor Castañeda

Prof. Asistente, Subdirector TICs, Proyecto Telemedicina

Tecnologia Medica

Universidad de Chile

Santiago, Chile

3
Daniel Droguett

Profesor Conferenciante

Estomatología

Universidad de Talca

Talca, Chile

3
Ana Liempi

Investigador

Instituto de Ciencia Biomedica

Universidad de Chile, Facultad de Medicina

Santiago, Chile

2
Juan Maya

Associated Proffesor

Instituto de Ciencias Biomedicas

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

2
Tatiana Adasme

Associate Professor, CIBQA Researcher

Centro Integrativo de Biología y Química Aplicada (CIBQA)

Universidad Bernardo OHiggins

Santiago, Chile

2
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

2
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

2
Matias Escobar

Postdoctoral Researcher

Cancer Biology

University of Pennsylvania

Philadelphia, Chile

2
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

2
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Lorena Abarzúa

Investigador

Medicina

Universidad de los Andes

Santiago, Chile

1
Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

1
Rodrigo Aguilar

Postdoctoral Fellow

Genetics

Harvard University

Boston, Estados Unidos

1
Juan Valdés

Head lab

Ciencias Biologicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Maria Paz Marzolo

Profesor Asociado

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

1
Isabel Castro

Profesor Asistente

Tecnología Médica

Universidad de Chile

Santiago, Chile

1
Sergio González

Profesor titular

Patología General y Oral

Universidad Mayor

Santiago, Chile

1
Amelina Albornoz

Post doctorado

Virología Molecular

Fundación Ciencia & Vida

Santiago, Chile

1
Hery Urra

Postdoctorado

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Felipe Bodaleo

Postdoctoral Researcher

Universidad de Chile

Santiago, Chile

1
Andrea Maturana

Academico

Patologia y Medicina Oral

Facultad de Odontologia

Santiago, Chile

1
Ignacio Niechi

Profesor Adjunto

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
JUAN AITKEN

PROFESOR ASISTENTE

PATOLOGIA Y MEDICINA ORAL

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
German Reig

Investigador Principal

Centro integrativo de Biología y Química Aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Prosesor Asociado

Facultad de Medicina - Clinica Alemana

Universidad Del Desarrollo

santiago, Chile

1
Maria Diaz

Part time Professor

Ciencias Quimicas y Biologicas

Universidad Bernado O´higgins

Santiago , Chile

1
Andrea González

Investigadora Asociada

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

Santiago, Chile

1
Rodrigo Assar

Adjoint Professor

Facultad de Medicina

Universidad de Chile

Santiago, Chile

1
Eugenia Diaz

Profesor Asistente

Facultad de Medicina

Universidad de Chile

Santiago, Chile

1
Francisco Aguayo

Profesor Asociado

Departamento de Oncología Básico Clínica

Universidad de Chile

Santiago, Chile

1
Iris Espinoza

Associated Professor

Departament of Oral Patology and Medicine

Universidad de Chile

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Jose Arias

Full Professor

Animal Biology

FACULTAD DE CIENCIAS VETERINARIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
GALIA RAMIREZ

PROFESOR ASISTENTE

DEPARTAMENTO DE MEDICINA PREVENTIVA ANIMAL

UNIVERSIDAD DE CHILE - FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

1
CAROLINA VALCK

ASSISTANT PROFESSOR

IMMUNOLOGY DISCIPLINARY PROGRAM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Berta Espinosa

Assistant Professor

Tecnología Médica

Universidad de Chile

Santiago, Chile

1
Denise Riquelme

Adjunct Professor

Biology

Universidad de Santiago

Santiago, Chile

1
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

1
Rodrigo Sandoval

Director de departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Jose Delpiano

Profesor Asistente

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Andrea Paula

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

1
estibaliz ampuero

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Maria González

Academico

FACULTAD DE MEDICINA - UNIVERSIDAD DE CHILE

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

1
Barbara Bruna

Asistente de Investigación Proyecto Fondecyt 1190958

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

1
MARIA HIDALGO

Associate professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Claudio Molina

Director Investigación

Investigación

Universidad San Sebastián

Santiago, Chile

1
José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Ulises Urzúa

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rina Ortiz

Profesor auxiliar

Física

Universidad Técnica Federico Santa María

Valparaiso, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Italo Espinoza

Lab Manager

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

1
Hugo Folch

Professor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile