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Nibaldo Manuel Inestrosa Cantin

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Discipline: Cellular and Molecular Biology / Molecular Neurobiology. Wnt Signaling and Synaptic function; Neuroprotection against amyloid-promoting damage at the synaptic level; Use of dual-AChE inhibitors with anti-Alzheimer.

Educación

  •  Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1979
  •  Biologist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1974

Experiencia Académica

  •   Full Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Biological Sciences

    Santiago, Chile

    1983 - A la fecha

Experiencia Profesional

  •   Full Professor Full Time

    PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

    Santiago, Chile

    1983 - A la fecha

Formación de Capital Humano


Postgraduate

1. Enrique Brandan Siques. Title: Anchorage of the Acetylcholinesterase to the basal lamina. Year: 1985.

2. Mª Elena Fuentes L. Title: The acetylcholinesterase in the mammalina central nervous system: Structural characterization of the enzyme and its expresión during the neuronal differentiation. Year: 1990.

3. Ricardo Moreno Mauro. Title: Study of the acetylcholinesterase during the development of the mammalian nervous system. Year: 1996.

4. Alejandra Alvarez Rojas. Title: Acetylcholinesterase promotes fibrilogenesis of the ?-amyloid peptide. Year: 1998.

5. Frances Calderón Hafon. Title: Efectos neurotóxicos del péptido ?-Amiloide (A?) y la acetilcolinesterasa (AChE). Year: 1999.

6. Ariel Reyes Zambrano. Title: Caracterización de nuevos modelos animales para el estudio de la enfermedad de Alzheimer. Year: 2000.

7. Francisca Bronfman Cáceres. Title: Amyloidogenesis and the Cholinergic System in Alzheimer’s disease: from in vitro análisis to Transgenic Mice Models” Co-Promotor Thesis. Doctor in Medical Sciences, Katholieke Univesiteit, Leuven, Belgium. Year: 2000.

8. Paola Deprez Mateljan. Title: Characterization of collagenous tail of the asymmetric acetylcholinesterase and its interaction with the basal lamina. Year: 2000.

9. Sandra Luza Cornejo. Title: Effect of the CGRP peptide derived from the clacitonin gene, on neuronal cells: Regulation of the molecular forms of Acetylcholinesterase (Universidad de Chile; Facultad de Ciencias Químicas y Farmaceúticas). Year: 2000.

10. Giancarlo De Ferrari Valentini. Title: Identification and characterization of the polypeptide domains that allows the interaction between acetylcholinesterase and the -amyloid peptide.
Year: 2001.

11. Carlos Opazo Martínez. Title: Neuroprotective effect of proteins from the central nervous system over the -amyloid fibrils toxicity. Year: 2002.

12. Carlos Morgan Sabat. Title: Laminine inhibits -amyloid deposition in vitro. Implicances for Alzheimer´s disease. Year: 2002.

13. Rebeca Aldunate Magalhaes. Title: Study of the role of CGRP in the expression of the enzyme acetylcholinesterase neuromuscular junction in culture. Year: 2002.

14. Rodrigo Fuentealba Alday. Title: Participación de la vía de transducción de señales Wnt en la toxicidad del péptido ?-amiloide en modelos celulares de la enfermedad de Alzheimer.
Year: 2005.

15. Lorena Varela Nallar. Title: Efectos del cobre sobre la expresión génica y propiedades de la proteína prion celular (PrPc) en células neuronales. Year: 2005.

16. Marcelo Chacón. Title: Papel de los receptores Frizzled en la Neuroprotección frente a la Toxicidad inducida por el péptido-b-amiloide. Year: 2007.

17. Mary Carmen Vázquez. Title: Modulación de la Actividad Celular del Fragmento AICD por la quinasa c-Abl en presencia de la Proteína Adaptadora Fe65. Co-tutoría con Dr. Alejandra Alvarez. Year: 2008.

18. Marcela Colombres. Title: La Vía de señalización Wnt modula la adehesión sináptica mediada por N-cadherina. Year: 2009.

19. Enrique Toledo. Title: Protección contra la neurotoxicidad del peptido ?-Amiloide en un modelo doble transgénico de la enfermedad de Alzheimer. Year: 2009.

20. Ginny Farias. Title: La Vía de Señalización Wnt promueve la organización del terminal pre-sináptico en el SNC maduro: Papel de APC en la localización sináptica de los receptores nicotinicos ?7. Year: 2009.

21 Waldo Cerpa Nebott. Title: Participación de la vía Wnt en la sinopsis CA3-ca1 del hipocampo de rata: efecto de los oligómeros del péptido ? amiloide. Year: 2009.

22. Margarita Dinamarca. Title: La proteína neuroligina es un agente nucleador del péptido ?-amiloide in vitro y une los oligómeros de A? a la sinápsis neuronal. Year: 2009.

23. Jessica Scheu. Title: Disabled-2 (Dab-2) Regula la Señalización Wnt en un Modelo Neuronal. Co-tutoría Dr. María Paz Marzolo. Year: 2009.

24. Ivan Alfaro. Title: Papel de la vía de señalización Wnt no canónica en la morfogénesis y plasticidad estructural de espinas dendríticas en neuronas hipocampales de rata. Year: 2011.

25. Loreto Cuitiño. Title: Modulación de la sinapsis inhibitoria GABAérgica por la vía de señalización Wnt. Year: 2011.

26. Claudio Allard. Title: Papel de la proteína SIRT 1 en la sinapsis neuronal: Protección contra los oligómeros del péptido A? en la enfermedad de Alzheimer. Year: 2013.

27. Daniela Rebolledo. Title: Restoration of nNOSµ Function in the mdx Mouse Model of Duchenne Muscular Drystrophy. Year: 2013.

28. Macarena Arrazola. Title: Efectos de la Vía de Señalizacion Wnt sobre la permeabilidad mitocondrial inducida por oligómetros del Péptido b-Amiloide. Year: 2014.

29. Juan Francisco Codocedo. Title: Estudio del papel de microRNAs sobre la remodelacion post-sináptica inducida por el ligando Wnt-5a. Year: 2014.

30. Jessica Vargas. Title: Involvement of Wnt Signaling Pathway in the adult hippocampal Synapses: Role in Neuroprotection. Year: 2014.

31. Valerie Ramirez. Title: Estudio de los mecanismos celulares del ligando Wnt-5A en neuronas hipocampales: Identificación del receptor Frizzled y rol de las proteínas G triméricas. Year: 2015.

32. Catherina Cuevas. Title: Regulación de la Via de señalización Wnt por Angiotensina II y Angiotensina-(1-7): Participación en la fibrosis renal. Co-tutela Dr. Carlos Vío. Year: 2016.

33. Cheryl Tapia. Title: Implicancias de la pérdida de la señalización Wnt canónica en etapas pre-sintomáticas de la Enfermedad de Alzheimer sobre el desarrollo de la patología. Year: 2016.

34. Juvenal Rios. Title: Implicancias de la vía de señalización Wnt en funciones del metabolismo neuronal. Year: 2017.

35. Carla Montecinos. Title: El ligando Wnt5a promueve la formación del complejo trimérico PSD95-Stargazin-receptor AMPA, generando neuroprotección contra oligómeros A?1-42. In progress.

Postdoctoral training

1. Dr. Jack Yamuy, MD, 1984, Universidad de la República, Uruguay.
2. Dr. Ricardo Fadic, MD, 1988-1989, Universidad Católica de Chile.
3. Dr. Claudio Soto, PhD, 1995-1996, Universidad de Chile.
4. Dr. Francisco José Muñoz, PhD, 1997-1999, España.
5. Dr. Maria Paz Marzolo Ph.D. (1998-1999), Universidad Católica de Chile.
6. Dr. Alejandra Alvarez, PhD, 2000, Universidad Católica de Chile.
7. Dr. Alicia Minniti, PhD, (2000-2003), Universidad de Rosario, Argentina.
8. Dr. Rodrigo Quintanilla, PhD, (2004-2005), Universidad de Chile.
9. Dr. Rodrigo Fuentealba, PhD, (2005-2006) Universidad Católica de Chile.
10. Dr. Lorena Varela, PhD, (2005-2006), Universidad Católica de Chile.
11. Dr. Rebeca Aldunate, PhD, (2007-2008), Universidad Católica de Chile.
12. Dr. Rosana Mesa, PhD, (2007 - 2008), Universidad Nacional de San Luis, Argentina.
13. Dr. Gesa Consiglieri, PhD, (2007 - 2008), Universidad de Berlín, Alemania.
14. Dr. Christopher Adams, PhD, (2008 - 2008), PUC-Univ. Paul Sabatier, Francia.
15. Dr. Rebecca Graumann, PhD, (2008 –2009), Universidad de Chile.
16. Dr. Mary Carmen Vazquez, PhD, (2008 -2009), Universidad Católica de Chile.
17. Dr. Ivan Neira, PhD, (2009 -2010), Univ. de Antofagasta, Chile.
18. Dr. Lorena Varela-Nallar, PhD, (2009 -2012), Universidad Católica de Chile.
19. Dr. Jorge Parodi, PhD, (2009 -2011), Universidad de Concepción, Chile.
20. Dr. Andrea Calixto, PhD, (2009 -2012), Columbia University, New York, USA.
21. Dr. Carla Calderon, PhD, (2011-2012), University of Lund, Sweden.
22. Dr. Carolina Oliva, PhD, (2010- ), Univ. Valparaiso-University of Yale.
23. Dr. Juan Zolezzi, PhD, (2011-2012), University of Bologna, Italy.
24. Dr. Pedro Cisternas, PhD, (2012- ), Universidad de Concepcion, Chile.
25. Dr. Carmen Silva, PhD, (2012-2016), Universidad de Concepcion, Chile.
26. Dr. Ting Cao, PhD, (2013), University of Milan, Milan, Italy.
27. Dr. Claudio Pinto, (2013- 2015 ), Universidad Católica de Chile.
28. Dr. Macarena Arrazola, (2014 - 2015 ), Universidad Católica de Chile.
29. Dr. Juan Francisco Codocedo, (2014-2016), Universidad Católica de Chile.
30. Dr. Eva Ramos PhD, (2013- ), Universidad Pompeu Fabra, Barcelona, España.
31. Dr. Catherine Lambert, (2013- ), Universidad de Paris, Francia.
32. Dr. Daniela Vallejo, (2016- ), Universidad de Valladolid, España.
33. Dr. Daniela Rivera, (2016- ), Universidad Católica de Chile.


Difusión y Transferencia


National and International collaborations

- CEBIMA: During the last years, the permanent development of the main research line, has allowed the establishment of a formal collaboration between the Universidad Católica de Chile, specifically through CARE Chile - UC, with the Universidad de Magallanes for the constitution of the Center of Excellence in Biomedicine Research of Magallanes (CEBIMA). The main scope of this center is the identification and development of new compounds potentially useful as therapeutical agents against chronic diseases, using the knowledge obtained from basic research focused to investigate the aquatic and terrestrial ecosystems of the Magallanes region and the chilean Antartica.

- We have developed several international collaborations with remarkable scientist all over the world

Dr. Michael Bader, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Dr. Daniel Choquet, Director Interdisciplinary Institute of Neuroscience, University of Bordeaux, France.
Dr. Hollis Cline, Scripps Institute, La Jolla, San Diego, CA, USA. Current President of the Society for Neuroscience.
Dr. David Sabatini, New York University Medical Center, NY, USA.
Dr. Freda Miller, Sick Children´s Hospital, Toronto, Canada.
Dr. Robson Santos, Director NanoBioPharm Institute, Universidade Federal do Minas Gerais, Belo Horizonte, Brazil.
Dr. Ariel Feldstein, University of California (UCSD) San Diego, CA, USA.
Dr. Giampietro Schiavo, Institute of Neurology, University College London (UCL), UK.

Symposia and Seminars

1. Leighton, F., Bronfman, M. and Inestrosa, N.C. (1977) Peroxisomes and hypolipidemic agents. In Symposium "Biotransformation of drugs". II Meet. Latinoamerican Assoc. Pharmacol. Viña Del Mar, Chile.

2. Leighton, F., Bronfman, M. and Inestrosa, N.C. (1979) Organization of the system of fatty acid oxidation peroxisomes. Proposition of a model. In Symposium "Biochemistry of Lipids and Isoprenoids". II Meet Southern Cone, Panamerican Biochem. Soc. Chile. Viña del Mar, P. 241.

3. Hall, Z.W., Silberstein, L., Inestrosa N.C., Sanes, J. and Weinberg, C. (1981) Synapse-specific componentes of the neuro-muscular junction. INC-UCLA Symposia "Cellular Recognition", USA., Colorado, Keystone J. Supra Mol. Struct. Cell Biochem. Suppl. 5, P. 248 (Abstract 672).

4. Inestrosa, N.C., Maldonado, M. and Garrido, J. (1984) Direct connection between extracellular basal lamina and cytoplasmic filaments. ICN-UCLA Symposia "Extracellular Matrix: structure and function", April 22.-29, 1984, Colorado, USA., J. Cell Biochem. Suppl. 8b, Abstract N° 1608.

5. Maldonado, M., Torres, J.C., Garrido, J., Brandan, E. and Inestrosa, N.C. (1984) The anchorage of acetylcholinesterase to the synaptic basal lamina is mediated by heparin-like macromolecules. ICN-UCLA Symposia "Extracellular matrix: structure and function", April 22-29, 1984, Colorado, USA. J. Cell Biochem. Suppl. 8b, Abstract N° 1599.

6. Inestrosa, N.C. (1989) Dinámica de la sinapsis colinérgica: Singer Symposium. XXXII Reunión Anual Sociedad de Biología de Chile. Viña del Mar, Noviembre.

7. Inestrosa, N.C. (1990) Aspectos biotecnológicos en biología marina. En: Simposio "Demandas de investigacion básica sobre recursos marinos: Un desafío para el desarrollo Ecónomico sostenido nacional". XXXIII Reunión Anual Sociedad de Biología de Chile. Punta de Tralca, Noviembre. Arch. Biol. Med. Expt. 23: R.200.

8. Inestrosa, N.C., Palma, V. and Godoy, J. (1991) Expression of Beta-amyloid precursos protein in cell lines and blood cells of alzheimer patients. Internatl. Symposium "The cytoskeleton in cell differentiation, Santiago, 3-4 Diciembre.

9. Inestrosa N.C., “Envejecimiento Cerebral y Estrógenos”, Symposium Estrógenos y Condición Mental de la Mujer. . Santiago – Chile (Junio 02 – 1995).

10. Inestrosa N.C., “Enfermedad de Alzheimer: Diferencias entre el hombre y la mujer”. Efectos de la THR. II Simposio Internacional de Menopausia y Envejecimiento. Impacto del Climaterio en la Salud Mental. Santiago – Chile (Dic. 06 - 1996).

11. Pérez, D., Alarcón, R., and Inestrosa, N.C. (1998) Kinetic and thermodynamic effects of acetylcholinesterase on the solubility of A?-peptide. Xth Internat. Symp. on Cholinergic Mechanisms. 1-5 September, Arcachon, France. J. Physiol (Paris) 92: 479.

12. Deprez, P., Krejci, E., Massoulié, J. and Inestrosa, N.C. (1998) Dissection of the heparin-binding domains present in the collagenic tail of mammalian acetylcholinesterase. Xth Internatl. Symp. on Cholinergic Mechanisms. 1-5 September, Arcachon, France. J. Physiol (Paris) 92: 425 (Abstr. 26).

13. Inestrosa, N.C. (1995) “Oxidative Stress Impact in Alzheimer Disease”, Simposio Biology and Pathology of free radicals: Plant and Wine Polyphenol Antioxidants. Santiago, Chile (Julio 29 – 30).

14. Ruiz, F.H., Silva, E., and Inestrosa, N.C. (1999) Prion protein (PrP59-61) has the ability to reduce copper (II): Role of Tryptophan. The Protein Society. Third European Symposium. 19-22 September. Garmisch Partenkirchen, Germany. PROTEIN SCIENCE 8: p. 68 Abstr.194.

15. Inestrosa, N.C. and Morgan, C., (2000) Interaction of laminin-1 with amyloid ?-peptide. Implications for Alzheimer’s Disease. Intl. Symposium on Extracellular Matrix. Angra dos Reis, Río de Janeiro, September 24-27, (Abs. S-119).

16. De Ferrari, G.V. e Inestrosa N.C. (2000) Acetylcholinesterase induced ?-Amyloid and Neurotoxicity. Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy. Stockholm, Sweden (April 05 – 08).

17. Inestrosa N.C. “Role of Copper in Alzheimer’s and Prion Diseases” NIH Chile research cooperation Workshop inhealth and environment. Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago – Chile (April 04 – 06, 2001).

18. N.C. Inestrosa and G.V. De Ferrari. Therapy-"Cholinesterase Inhibitors with Anti-Amyloid properties"-.International Geneva/Springfield Symposium on Advances in Alzheimer .Ginebra-Suiza-7th, 3 al 8 de Abril, 2002.

19. Inestrosa, G.V. De Ferrari, J.L. Garrido, A. Alvarez, M. Bronfman. "Neurodegenerative Processes in Alzheimer´s Disease"- International Symposium on Cholinergic Mechanisms-St. Moritz-Switzerland-XI, 5 al 9 de Mayo 2002.

20. Inestrosa NC. “AChE inhibitors, properties of AChE/Ab complexes and the Wnt pathway” 8th International Montreal/Springfield, Symposium on Advances in Alzheimer Therapy, Montreal, Quebec, Canada del 13 al 17 de Abril 2004.

21. Inestrosa NC. “Wnt Signaling in Synaptic Function: Specific A? Effects”. First Chilean International Symposium on Neurodegenerative Diseases, Santiago Chile, November 21 al 25 de 2005.

22. Fuentealba R, Retamal C, Bu G, Inestrosa NC and Marzolo MP. “ApoER2 Modulates A? Levels and Interacts with app in Cultured cell lines”. First Chilean International Symposium on Neurodegenerative Diseases, pag. 81, Santiago Chile, November 21 al 25 de 2005.

23. Parodi J, Sepúlveda F, Godoy J, Inestrosa NC and Aguayo LG. “Nanomolar Concentrations of ?-amyloid Aggregates Reduce Spontaneous Synaptic Activity in Hippocampal Neurons”. First Chilean International Symposium on Neurodegenerative Diseases, pag. 84, Santiago Chile, Noviembre 21 al 25 de 2005.

24. Pérez de Arce K, Inestrosa NC and Alvarez A. “c-Abl Kinase Interacts with Proteins of Synaptic Structures and its Effect is Modulated by Lithium”. First Chilean International Symposium on Neurodegenerative Diseases, pag. 85, Santiago Chile, Noviembre 21 al 25 de 2005.

25. Vázquez MC, Alvarez A and Inestrosa NC. “APP Swedish Expresión in N2A Cell Induces Neprylisin expression: Possible Role of the AICD/FE65/c-Abl Complex”. First Chilean International Symposium on Neurodegenerative Diseases, pag. 86, Santiago Chile, Noviembre 21 al 25 de 2005.

26. Lazo O, Manuna J, Inestrosa NC and Bronfman FC. “Neurotrophic Retrograde Signaling of Septohippocampal Pathway Supports Phenotypic Differentiation but not Survival of Cholinergic Neurons”. First Chilean International Symposium on Neurodegenerative Diseases, pag. 86, Santiago Chile, Noviembre 21 al 25 de 2005.

27. Inestrosa NC. “Cellular Signalling Pathways on ?-amyloid Peptide Neurodegeneration”. 13th International Symposium on Chromaffin Cell Biology, (pag. 56), Pucón - Chile (Enero 07 – 12 de 2006).

28. Farías G and Inestrosa NC. “?7-Nicotinic Acetylcholine Receptor Interacts With Tumor Suppressor APC in Presynaptic Regions of Hippocampal Neurons: Effect of Wnt.7a Ligand”. 13th International Symposium on Chromaffin Cell Biology, (pag. 92) Pucón - Chile (Enero 07 – 12 de 2006).

29. Dinamarca M, Cerpa W and Inestrosa NC. “?-Amyloid and Hydrogen Peroxide Neurotoxicity, Dissecting the Molecular Mechanisms”. 13th International Symposium on Chromaffin Cell Biology, (pag. 104) Pucón - Chile (Enero 07 – 12 de 2006).

30. Inestrosa N.C., “Wnt and calcium signaling in synaptic defferentiation and A? neuroprotection: role of CaMKIV. 13th. International Symposium on Chromaffin cell Biology. Pucón-Chile. (Enero 07 – 12, 2006).

31. Inestrosa NC. “Wnt Signaling Pathway and Synapse Differentiation” Spring Meeting 2006: “Symposium & Workshop on MOLECULAR AND CELLULAR BASIS OF NEUROCONNECTIVITY”, (L-7) Leuven – Belgium (Mayo 04 – 06 de 2006).

32. Fuentealba R, Inestrosa NC and Marzolo MP. “Trafficking and Functional Aspects of ApoER2: Its Role as a Regulator of APP Processing”. Spring Meeting 2006: “Symposium & Workshop on MOLECULAR AND CELLULAR BASIS OF NEUROCONNECTIVITY”, (L-13) Leuven – Belgium (Mayo 04 – 06 de 2006).

33. Inestrosa N.C. “Mecanismos de Daño Neuronal en la Enfermedad de Alzheimer” Simposio Internacional: “Neuropsiquiatría y función gonadal”. Santiago – Chile (28 – 29 Marzo 2008).

34. Inestrosa N.C., , “Enfermedad de Alzheimer: Papel de la via Wnt” Ciclo de Conferencias “Topicos selectos en Biología y Biomedicina” Universidad de Antofagasta, Antofagasta – Chile (12 de Diciembre 2008).

35. Inestrosa N.C “Vía Wnt de Señalización Modula la Maduración de las Regiones Pre- y Postsinápticas del Sistema Nervioso de Vertebrados” V Reunión Sociedad Chilena de Neurociencias, Coquimbo, Chile (Septiembre 23 – 25, 2009).

36. Inestrosa N.C. “Regulation of central synapses by Wnt signaling” Chilean Science Meets the Max Planck Institutes, Max Planck-Conicyt – Centro Interdiciplinario de la Universidad de Valparaíso (CINV) Valparaíso-Chile (January 11 - 13 de 2010).

37. Calderón F.H., De Mello F.G. and Campos E.O. Inestrosa N.C., “The Response of Retina to Biological Insults”. “Neurotoxicity of ?-Amyloid Aggregates and Ache-A Complexes in Avian Retina Cell Cultures”. Simposio Third IBRO Regional Meeting, San – Sabro 1998. Puerto Iguazú, Argentina (Nov. 30 – Dic. 03, 2008).

38. Inestrosa, N.C., Canales, M., Alarcón, R. & De Ferrarri G.V. “Acetylcholinesterase Promotes Amyloid Fibril Formation”, Fifth Ibro World Congress of Neuroscience. Jerusalem, Israel. (July 11 – 15, 1999).

39. Inestrosa N.C. and G.V De Ferrari.. “Acetylcholinesterase induced ?-Amyloid and Neurotoxicity”, Sixth International Stockholm / Springfield Symposium on advances in Alzheimer Therapy. Stockholm, Sweden (April 05 – 08, 2000).

40. Inestrosa, N.C., “Acetylcholinesterase and -amyloid interactions”. Esn Conference on: Advances in Molecular Mechanisms of Neurological Disorders ESN Conference on: “Advances in Molecular Mechanisms of Neurological Disorders. Perugia, Italy, (May 22-25, 2001).

41. Inestrosa, N.C., “Wnt Pathway Mediates Amyloid Neurotoxicity”. ISN Satellite Meeting: Cell Communication in the Nervous System-Function and Dysfunction. Río de Janeiro, Brasil, (August 22-24, 2001).

42. Inestrosa, N.C., “The Wnt signalling Patchway in Neuronal developmet” University of texas medical branch, dep. of physiology and biophysics, Galveston Texas, USA, (June, 27 – 29, 2002).

43. Inestrosa, N.C., Conferencia H. Niemeyer “Función de la Vía Wnt en el Sistema Nervioso” iv Jornadas de Bioinformatica y XXVI Congreso, organizado por la Sociedad Española de Bioquímica y Biología Celular SEBBM, La Coruña, España (Septiembre 15 – 18, 2003).

44. Inestrosa, N.C., AChE inhibitors, properties of AChE/A? complexes and the Wnt pathway. 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy. Montreal, Quebec, Canada. (Abril 14 – 19, 2004).

45. Inestrosa, N.C., “Activation of WNT signaling protects from A? neurotoxicity”. Alzheimer’s and Parkinson’s diseases: new perspectives 7th International Conference,. Sorrento, Italy (March 8-12, 2005).

46. Inestrosa N.C., “Wnt Signaling Pathway and Synapse Differentiation” Spring Meeting 2006: “Symposium & Workshop on Molecular and Cellular Basis of Neuroconnectivity”, Leuven – Bélgica (Mayo 04 – 06, 2006).

47. Inestrosa N.C., “The Wnt Signaling Pathway and Its Relevance to Alzheimer Disease”. The 10th. International Conference on Alzheimer’s Disease and Related Disorders, Madrid – España (Julio 15 – 20, 2006).

48. Inestrosa N.C., “Activation of Wnt signaling protects from: Amyloid neurodegeneration” Alzheimer’s & Parkinson Diseases: Advances, Concepts & New Challenges 9TH International Conference AD/PD 2009, Prague, Czech Republic (March 11 – 15, 2009).

49. Inestrosa N.C., “Amyloid beta oligomers at brain synapses” 11th International Geneva/Springfield Simposium on Advances in Alzheimer Therapy. Geneva – Switzerland, March 24 – 27, 2010.

50. Inestrosa N.C., “Role of Wnt signaling in synaptic function and neurodegeneration.” V Neurotoxicity Society Meeting. Uspallata, Mendoza – Argentina (Abril 7 – 10 de 2011).

51. Inestrosa NC,. “Activation of brain Wnt signaling in vivo: effect on LTP and spontaneous network activity” AD/PD 2013 The 11th International Conference on Alzheimer‘s & Parkinson’s Diseases. 2013 Florence, Italy. (March 6-10 de 2013).

52.- Inestrosa NC. Posibles Blancos Moleculares del Litio en el Sistema Nervioso Central. Simposio “Potasio y litio, desde la biología a la medicina”. Santiago – Chile. (Noviembre 27, 2015).

53. Inestrosa NC. Effects of Wnt on Synaptic Structure and Function. Simposio “Synaptic Basis of Cognitive Dysfunction”. Valparaiso – Chile (October 23 – 24, 2014).

54. Inestrosa NC. “Wnt signaling and Alzheimer ?s disease”. International Symposium Biology of Neuropsychiatric Disorders. Valparaiso - Chile Nibaldo Inestrosa (Abril 27 – 28, 2016).

55. Inestrosa NC. “Neuroprotection of AD in Octodon degus: Role of WNT pathway”. AD/PD 2017 Meeting, Vienna, April, 2017.

Outreach communications

1997: Inestrosa, N.C., Conferencia “Estrógenos y Alzheimer”, JORNADA ANUAL DE ENDOCRINOLOGÍA Y METABOLISMO 1997 Olmué, Chile (Octubre 17 – 18)

2005: Inestrosa, N.C. “Papel de la Vía Wnt en la Función Sináptica, y en el Alzheimer”, XXII CONGRESO NACIONAL DE ESTUDIANTES DE BIOQUÍMICA, Universiad Nacional Andrés Bello. Santiago – Chile. (Agosto 3)

2005: Inestrosa NC. “¿Porqué la Vía de Señalización Wnt es Importante en Neurociencia?” Conferencia Plenaria. 1er Congreso de la Sociedad Chilena de Neurociencia, (Abst P2) Santiago Chile, (Diciembre 1 – 2)

2007: Inestrosa N.C., XV CONGRESO CHILENO DE QUÍMICA CLÍNICA,”Las Incomunicaciones del Alzheimer”. Pucón – Chile (Octubre 04 – 06).

2008: Inestrosa N.C. “Wnt signaling Pathway: from Alzheimer’s disease to synaptic function”, XVIII Congreso de la Asociación Latinoamericana de Farmacología, Coquimbo – Chile (Octubre 12 – 16).

2011: Inestrosa NC, Aldunate R, Minniti A On the function of copper in s-IBM. IV International Workshop on Iron and Copper Homeostasis. Pucón Chile, Nov 30 – Dec 3,

2013: Inestrosa NC, “Un científico nace o se hace: el camino al Alzheimer”. Feria Científica y Tecnológica. Osorno Chile, Agosto 12-13.

2013: Inestrosa NC, “Degú como un modelo de AD estudios recientes en cerebro, incluyendo la presencia de componentes de la vía Wnt”. Conferencia en el Instituto Brain Science de Australia. Sidney – Australia, Octubre 14.

2013: Inestrosa NC, “Porque Perdemos la Memoria: La enfermedad de Alzheimer”. Ciclo de Charlas Explora. Puerto Montt-Chile, Noviembre 21-22.

2013: Inestrosa NC, “Productos naturales para combatir la enfermedad de alzheimer”. Ciclo Charlas Universidad Santo Tomas. Santiago – Chile. Noviembre 27.

2013: Inestrosa NC, “Investigaciones en la enfermedad de Alzheimer”. Primer encuentro Vasco-Chileno de Investigación Biomédica. Santiago – Chile, Diciembre 02.

2013: Inestrosa NC, “Incomunicaciones del Alzehimer”. Charla en el Instituto Instituto de Sistemas Complejos. Valparaiso – Chile. Diciembre 15.

2014: Inestrosa NC, “Determinantes biológicos asociados a la longevidad”. El Congreso Nacional de Geriatría y Gerontología de Chile. Santiago – Chile. Junio 30.

2014: Inestrosa NC, “¿Por qué Investigar? O ¿Por qué Investigo?. Charla hospital Sotero del Rios. Santiago – Chile. Agosto 21.

2017: Inestrosa NC, “Papel de la Via Wnt en la Enfermedad de Alzheimer: Rol del Litio” Facultad de Ciencias, Universidad de Chile, 23 de Agosto.


Premios y Distinciones

  •   PLOS ONE Article in the Top 10% Most Cited

    PLoS One

    Estados Unidos, 2017

    PLOS ONE Article in the Top 10% Most Cited

  •   Scopus-Elsevier Prize in Medical Science for ISI citations.

    Scopus-Elsevier

    Chile, 2013

    Number of publications and citations

  •   Top-3 cited paper FEBS Journal

    FEBS Journal

    Chile, 2010

    Highly cited paper

  •   Faculty of 1000-Medicine

    Faculty of 1000 members

    Estados Unidos, 2009

    Scientific Career award

  •   Premio Nacional de Ciencias

    Chilean Government

    Chile, 2008

    Outstanding career award

  •   Beca UNESCO Curso “Aspectos Químicos y Eléctricos de la Neurotransmisión”

    IVICS Venezuela

    Venezuela, 1977

    To study the Chemistry and Electrical properties of Neurotransmission.

  •   Postdoctoral grant

    MUSCULAR DYSTROPHY ASSOCIATION OF AMERICA

    Estados Unidos, 1980

    Neurochemical and neurobiological approach to muscular dystrophy

  •   Course grant

    European Molecular Biology Organization

    España, 1982

    Course on Developmental Genetics of Drosophila.

  •   Premio en Ciencia y Tecnología “Manuel Noriega Morales”

    Consejo Interamericano para la Educación, la Ciencia y la Cultura (OEA)

    Chile, 1986

    Significant contribution to Biochemistry and Neurobiology fields.

  •   BERNARDO HOUSSAY del Consejo Nacional de Investigación Científica de Argentina

    Asociación Latinoamericana de Ciencias Fisiológicas

    Argentina, 1988

    Gold medal and plenary conference for young scientist in the field of physiology.

  •   CATEDRA PRESIDENCIAL DE CIENCIA

    Gobierno de Chile

    Chile, 1996

    Study of Synaptic Acetylcholinesterase

  •   fellowship

    JOHN SIMON GUGGENHEIM MEMORIAL FOUNDATION

    Estados Unidos, 1999

    A study of the interaction of cholinesterases with the amyloid-b-peptide

  •   CATEDRA PRESIDENCIAL DE CIENCIA

    Gobierno de Chile

    Chile, 1999

    Molecular Basis of the Amyloid Deposits and Neurotoxicity

  •   Academic Degree Professor Emerito

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2018

    Academic Degree Award Ceremony, Professor emerito


 

Article (326)

"Live together, die alone": The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress.
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice.
Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus.
Andrographolide restores glucose uptake in rat hippocampal neurons.
Canonical Wnt Signaling Modulates the Expression of Pre- and Postsynaptic Components in Different Temporal Patterns.
Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus
Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus
Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex.
Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation.
Potential Role of Autonomic Dysfunction in Covid-19 Morbidity and Mortality.
Wnt Signaling Pathway Dysregulation in the Aging Brain: Lesson From the Octodon Degus
Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling.
Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus
Diterpenes and the crosstalk with the arachidonic acid pathways, relevance in neurodegeneration.
Fructose and prostate cancer: toward an integrated view of cancer cell metabolism.
GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus
Modulating Wnt signaling at the root: Porcupine and Wnt acylation
Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment.
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.
Presymptomatic Treatment With Andrographolide Improves Brain Metabolic Markers and Cognitive Behavior in a Model of Early-Onset Alzheimer's Disease
Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
Wnt Signaling Upregulates Teneurin-3 Expression via Canonical and Non-canonical Wnt Pathway Crosstalk
Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling
APP/Go protein Gb gamma-complex signaling mediates A beta degeneration and cognitive impairment in Alzheimers disease models
Hypothyroidism and Cognitive Disorders during Development and Adulthood: Implications in the Central Nervous System
Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is Associated with Higher Metabolism, Reduced Synaptic Plasticity and Cognitive Impairment in Octodon degus
Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease.
Modulation of Glucose Metabolism in Hippocampal Neurons by Adiponectin and Resistin
Neuroprotective Effects of Ferruginol, Jatrophone, and Junicedric Acid Against Amyloid-beta Injury in Hippocampal Neurons
New Insights into the Spontaneous Human Alzheimer's Disease-Like Model Octodon degus: Unraveling Amyloid-? Peptide Aggregation and Age-Related Amyloid Pathology
Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons
The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons
Wnt Signaling in the Central Nervous System=> New Insights in Health and Disease.
Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimers disease in J20-APP transgenic and wild-type mice
Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease
Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3 beta-AMPK axis
Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer’s disease
CDK5 downregulation enhances synaptic plasticity
Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
Identification of Cerebral Metal Ion Imbalance in the Brain of Aging Octodon degus
Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing hippocampal synaptic plasticity
INT131 increases dendritic arborization and protects against A beta toxicity by inducing mitochondrial changes in hippocampal neurons
PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation
Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and A beta Aggregates in Hippocampal Neurons: the Role of Mitochondria
Vertebrate Presynaptic Active Zone Assembly: a Role Accomplished by Diverse Molecular and Cellular Mechanisms
Wnt Signaling Prevents the A beta Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons
Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer's Disease
Activation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis
Amyloid-? Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity
Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus)
Frizzled-1 receptor regulates adult hippocampal neurogenesis
Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-? (A?) 42 peptides
Modulation of the NMDA Receptor Through Secreted Soluble Factors
On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae)
Posttranslational Modifications Regulate the Postsynaptic Localization of PSD-95
Recent advances in neuroinflammation therapeutics: PPARs/LXR as neuroinflammatory modulators
Reduction of Blood Amyloid-? Oligomers in Alzheimer?s Disease Transgenic Mice by c-Abl Kinase Inhibition
Regulation of Memory Formation by the Transcription Factor XBP1
Rhein-huprine derivatives reduce cognitive impairment, synaptic failure and amyloid pathology in A?PPswe/PS-1 mice of different ages
Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AβPPswe/PS-1 Mice of Different Ages
The G alpha(o) Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease
Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy
Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons
Wnt-5a/Frizzled9 Receptor Signaling through the G? o -G?? Complex Regulates Dendritic Spine Formation
Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons
A novel function for Wnt signaling modulating neuronal firing activity and the temporal structure of spontaneous oscillation in the entorhinal-hippocampal circuit
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus
Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3 beta: autoregulation of GSK-3 beta in vivo
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus
Angiotensin II increases fibronectin and collagen I through the beta-catenin-dependent signaling in mouse collecting duct cells
Anti-Ribosomal P Protein Autoantibodies From Patients With Neuropsychiatric Lupus Impair Memory in Mice
beta-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats
Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in A beta oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice
Monitoring mitochondrial membranes permeability in live neurons and mitochondrial swelling through electron microscopy analysis.
Pathogenicity of Lupus Anti-Ribosomal P Antibodies: Role of Cross-Reacting Neuronal Surface P Antigen in Glutamatergic Transmission and Plasticity in a Mouse Model
Teneurins and Alzheimer's disease: A suggestive role for a unique family of proteins
Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy
Tetrahydrohyperforin: a neuroprotective modified natural compound against Alzheimer's disease
The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease
The Protein Oxidation Repair Enzyme Methionine Sulfoxide Reductase A Modulates A beta Aggregation and Toxicity In Vivo
The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons
The soluble extracellular fragment of neuroligin-1 targets A beta oligomers to the postsynaptic region of excitatory synapses
WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by A beta oligomers
Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against AO oligomers
Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production
Andrographolide reduces cognitive impairment in young and mature A beta PPswe/PS-1 mice
Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons
Chronic hypoxia induces the activation of the Wnt/beta-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1 Delta E9 transgenic mice in vivo
Effects of Tetrahydrohyperforin in Mouse Hippocampal Slices: Neuroprotection, Long-term Potentiation and TRPC Channels
EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-beta Oligomers
In vivo Activation of Wnt Signaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model
Phosphorylated tau potentiates A beta-induced mitochondrial damage in mature neurons
PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors
Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain
Role of Wnt Signaling in Tissue Fibrosis, Lessons from Skeletal Muscle and Kidney
Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents
Wnt Signaling in Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse and Fibrosis
Wnt signalling in neuronal differentiation and development
Wnt-5 alpha increases NO and modulates NMDA receptor in rat hippocampal neurons
Wnt-5a Ligand Modulates Mitochondrial Fission-Fusion in Rat Hippocampal Neurons
ATP Induces NO Production in Hippocampal Neurons by P2X(7) Receptor Activation Independent of Glutamate Signaling
Canonical Wnt signaling protects hippocampal neurons from A beta oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics
Frizzled-5 Receptor Is Involved in Neuronal Polarity and Morphogenesis of Hippocampal Neurons
Nicotine Prevents Synaptic Impairment Induced by Amyloid-beta Oligomers Through alpha 7-Nicotinic Acetylcholine Receptor Activation
Peroxisome Proliferator-Activated Receptor (PPAR) gamma and PPAR alpha Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders?
Peroxisome Proliferators Reduce Spatial Memory Impairment, Synaptic Failure, and Neurodegeneration in Brains of a Double Transgenic Mice Model of Alzheimer's Disease
Tetrahydrohyperforin Decreases Cholinergic Markers associated with Amyloid-beta Plaques, 4-Hydroxynonenal Formation, and Caspase-3 Activation in A beta PP/PS1 Mice
Tetrahydrohyperforin Increases Adult Hippocampal Neurogenesis in Wild-Type and APPswe/PS1 Delta E9 Mice
Tetrahydrohyperforin Induces Mitochondrial Dynamics and Prevents Mitochondrial Ca2+ Overload after A beta and A beta-AChE Complex Challenge in Rat Hippocampal Neurons
Thiazolidinediones Promote Axonal Growth through the Activation of the JNK Pathway
Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease
Frizzled Receptors in Neurons: From Growth Cones to the Synapse
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease
Reusing and composing models of cell fate regulation of human bone precursor cells
SIRT1 Regulates Dendritic Development in Hippocampal Neurons
Synaptic defects associated with s-inclusion body myositis are prevented by copper
Wnt-5a Is a Synaptogenic Factor with Neuroprotective Properties against A beta Toxicity
Copper Reduces A beta Oligomeric Species and Ameliorates Neuromuscular Synaptic Defects in a C. elegans Model of Inclusion Body Myositis
HID-1, a New Component of the Peptidergic Signaling Pathway
Regulation of NMDA-Receptor Synaptic Transmission by Wnt Signaling
Tetrahydrohyperforin prevents cognitive deficit, A beta deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1 Delta E9 model of Alzheimer's disease: a possible effect on APP processing
The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2 X4 Receptors
The GABA(A)rho receptors in hippocampal spontaneous activity and their distribution in hippocampus, amygdala and visual cortex
The Synaptic Protein Neuroligin-1 Interacts with the Amyloid beta-Peptide. Is There a Role in Alzheimer's Disease?
Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1 Delta E9 mouse model of Alzheimer's disease
Amyloid-beta Peptide Fibrils Induce Nitro-Oxidative Stress in Neuronal Cells
Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the A beta peptide. Implications for the pathogenesis of Alzheimer's disease
Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons
beta-Amyloid Causes Depletion of Synaptic Vesicles Leading to Neurotransmission Failure
Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method
Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy.
Neuroinflammation, AD, and Dementia
Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation
The Hyperforin Derivative IDN5706 Occludes Spatial Memory Impairments and Neuropathological Changes in a Double Transgenic Alzheimer's Mouse Model
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses
Wnt signaling activation reduces neuropathological markers in a mouse model of Alzheimer's disease
Wnt-5a Modulates Recycling of Functional GABA(A) Receptors on Hippocampal Neurons
Wnt-5a occludes A beta oligomer-induced depression of glutamatergic transmission in hippocampal neurons
c-Abl Modulates AICD Dependent Cellular Responses: Transcriptional Induction and Apoptosis
Calcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/beta-Catenin Signaling Pathway
Intracellular amyloid formation in muscle cells of A beta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification
Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans
Overexpression of amyloid precursor protein increases copper content in HEK293 cells
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
THE ROLE OF WNT SIGNALING IN NEUROPROTECTION
Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons
beta-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway
Circadian stress tolerance in adult Caenorhabditis elegans
Frizzled-1 is involved in the neuroprotective effect of Wnt3a against a beta oligomers
Heparin activates Wnt signaling for neuronal morphogenesis
Release of acetylcholinesterase (ACH) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice
STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits
Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses.
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons
ApoER2 expression increases A beta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity
Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis
Synaptotoxicity in Alzheimer's disease: The Wnt signaling pathway as a molecular target
Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons
Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits
Induction of cellular prion protein gene expression by copper in neurons
Localization, specific activity, and molecular forms of acetylcholinesterase in developmental stages of the cestode Mesocestoides corti
The functional links between prion protein and copper
ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its rafts' association
Blood cells cholinesterase activity in early stage Alzheimer's disease and vascular dementia
Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu
Peroxisomal proliferation protects from beta-amyloid neurodegeneration
Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling
The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components
Acetylcholinesterase (AChE)--amyloid-beta-peptide complexes in Alzheimer's disease. the Wnt signaling pathway.
Acetylcholinesterase-A beta complexes are more toxic than A beta fibrils in rat hippocampus - Effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss
beta-sheet breaker peptide prevents A beta-induced spatial memory impairments with partial reduction of amyloid deposits
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation
M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway
Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease
Stepwise construction of triple-helical heparin binding sites using peptide models
Structural and functional organization of synaptic acetylcholinesterase
The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo
Wnt-3a overcomes ?-amyloid toxicity in rat hippocampal neurons
Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons
A human prion protein peptide (PrP59-91) protects against copper neurotoxicity
Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus
Acetylcholinesterase induces the expression of the beta-amyloid precursor protein in glia and activates glial cells in culture
Activation of Wnt signaling and behavioral impairments rescues neurodegeneration induced by beta-amyloid fibrils
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases
Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells
PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes
The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X(4) receptor without modifying the zinc action
Two different heparin-binding domains in the triple-helical domain of ColQ, the collagen tail subunit of synaptic acetylcholinesterase
Laminin affects polymerization, depolymerization and neurotoxicity of A beta peptide
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid - Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2
Protein kinase C inhibits amyloid beta-peptide neurotoxicity by acting on members of the Wnt pathway
Vitamin E but not 17 beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant
Wnt signaling involvement in beta-amyloid-dependent neurodegeneration
A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation
Interactions of laminin with the amyloid beta peptide. Implications for Alzheimer's disease
Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites
Acetylcholinesterase-amyloid-beta-peptide interaction and Wnt signaling involvement in A beta neurotoxicity
Amyloid-beta-peptide reduces copper(II) to copper(I) independent of its aggregation state
Expression of alpha(2)-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells
Interaction of collagen-like peptide models of asymmetric acetylcholinesterase with glycosaminoglycans: Spectroscopic studies of conformational changes and stability
Interaction of the collagen-like tail of asymmetric acetylcholinesterase with heparin depends on triple-helical conformation, sequence and stability
Molecular modeling of the collagen-like tail of asymmetric acetylcholinesterase
The N-terminal tandem repeat region of human prion protein reduces copper: Role of tryptophan residues
Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein
Mannose receptor is present in a functional state in rat microglial cells
Molecular modeling of the amyloid-beta-peptide using the homology to a fragment of triosephosphate isomerase that forms amyloid in vitro
Neurotoxicity of acetylcholinesterase amyloid beta-peptide aggregates is dependent on the type of A beta peptide and the AChE concentration present in the complexes
Neurotoxicity of acetylcholinesterase amyloid β-peptide aggregates is dependent on the type of Aβ peptide and the AChE concentration present in the complexes
PC12 and neuro 2a cells have different susceptibilities to acetylcholinesterase-amyloid complexes, amyloid25-35 fragment, glutamate, and hydrogen peroxide
Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase
A major portion of synaptic basal lamina acetylcholinesterase is detached by high salt- and heparin-containing buffers from rat diaphragm muscle and Torpedo electric organ
At least two receptors of asymmetric acetylcholinesterase are present at the synaptic basal lamina of Torpedo electric organ
Brain acetylcholinesterase promotes amyloid-beta-peptide aggregation but does not hydrolyze amyloid precursor protein peptides
Cellular and molecular basis of estrogen's neuroprotection - Potential relevance for Alzheimer's disease
Crosslinking of amyloid-beta peptide to brain acetylcholinesterase
Developmental regulation of mouse brain monomeric acetylcholinesterase
Estrogen protects neuronal cells from the cytotoxicity induced by acetylcholinesterase-amyloid complexes
Laminin blocks the assembly of wild type A beta and the Dutch variant peptide into Alzheimer's fibrils
Responses induced by tacrine in neuronal and non-neuronal cell lines
Responses induced by tacrine in neuronal and non-neuronal cell lines.
Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils
Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro
A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme
Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils
Abnormal development of the locomotor activity in yellow larvae of Drosophila: A cuticular defect?
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme
Amyloid precursor protein fragment and acetylcholinesterase increase with cell confluence and differentiation in a neuronal cell line
Extracellular matrix regulates the amount of the ?-amyloid precursor protein and its amyloidogenic fragments
Laminin inhibits amyloid-beta-peptide fibrillation
Laminin inhibits amyloid-β-peptide fibrillation
Sprouting and abnormal contacts of nonmedullated axons, and deposition of extracellular material induced by the amyloid precursor protein (APP) and other protease inhibitors
Tetrameric (G4) acetylcholinesterase: structure, localization, and physiological regulation
2 HEPARIN-BINDING DOMAINS ARE PRESENT ON THE COLLAGENIC TAIL OF ASYMMETRIC ACETYLCHOLINESTERASE
Acetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid-beta-peptides
Behavioral responses of Concholepas concholepas (Bruguiere, 1789) larvae to natural and artificial settlement cues and microbial films
EARLY AXONAL REGENERATION - REPRESSION BY SCHWANN-CELLS AND A PROTEASE
EFFECT OF PROTAMINE ON THE SOLUBILIZATION OF COLLAGEN-TAILED ACETYLCHOLINESTERASE - POTENTIAL HEPARIN-BINDING CONSENSUS SEQUENCES IN THE TAIL OF THE ENZYME
Mitosis of Schwann cells and demyelination are induced by the amyloid precursor protein and other protease inhibitors in the rat sciatic nerve
MITOSIS OF SCHWANN-CELLS AND DEMYELINATION ARE INDUCED BY THE AMYLOID PRECURSOR PROTEIN AND OTHER PROTEASE INHIBITORS IN THE RAT SCIATIC-NERVE
PLATELETS ARE THE PRIMARY SOURCE OF AMYLOID BETA-PEPTIDE IN HUMAN BLOOD
Platelets Are the Primary Source of Amyloid β-Peptide in Human Blood
The -Helical to -Strand Transition in the Amino-terminal Fragment of the Amyloid -Peptide Modulates Amyloid Formation
THE ALPHA-HELICAL TO BETA-STRAND TRANSITION IN THE AMINO-TERMINAL FRAGMENT OF THE AMYLOID BETA-PEPTIDE MODULATES AMYLOID FORMATION
Two heparin-binding domains are present on the collagenic tail of asymmetric acetylcholinesterase
BLOOD MARKERS IN ALZHEIMER-DISEASE - SUBNORMAL ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE IN LYMPHOCYTES AND ERYTHROCYTES
METAMORPHOSIS OF LABORATORY-REARED LARVAE OF CONCHOLEPAS-CONCHOLEPAS (MOLLUSCA, GASTROPODA)
MONOMERIC AMPHIPHILIC FORMS OF ACETYLCHOLINESTERASE APPEAR EARLY DURING BRAIN-DEVELOPMENT AND MAY CORRESPOND TO BIOSYNTHETIC PRECURSORS OF THE AMPHIPHILIC G(4) FORMS
SENSITIVITY OF ACETYLCHOLINESTERASE MOLECULAR-FORMS TO INHIBITION BY HIGH MGCL2 CONCENTRATION
Structural Determinants of the Alzheimer's Amyloid β-Peptide
A NEUROFILAMENT POLYPEPTIDE AND THE GLIAL FIBRILLARY ACIDIC PROTEIN SHARE COMMON EPITOPES IN THE VARIABLE REGION
ACETYLCHOLINESTERASE CHANGES IN HEARTS WITH SINUS RHYTHM AND ATRIAL-FIBRILLATION
EXTRACELLULAR-MATRIX COMPONENTS AND AMYLOID IN NEURITIC PLAQUES OF ALZHEIMERS-DISEASE
NERVE REGENERATION IS IMPROVED BY INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND BASIC FIBROBLAST GROWTH-FACTOR (BFGF)
PLATELET OF ALZHEIMER PATIENTS - INCREASED COUNTS AND SUBNORMAL UPTAKE AND ACCUMULATION OF [C-14] 5-HYDROXYTRYPTAMINE
Platelet of Alzheimer patients: Increased counts and subnormal uptake and accumulation of [14C]5-hydroxytryptamine
A HIGH-MOLECULAR-WEIGHT PROTEOGLYCAN IS DIFFERENTIALLY EXPRESSED DURING DEVELOPMENT OF THE MOLLUSK CONCHOLEPAS-CONCHOLEPAS (MOLLUSCA, GASTROPODA, MURICIDAE)
AMPHIPHILIC BEHAVIOR OF A BRAIN TETRAMERIC ACETYLCHOLINESTERASE FORM LACKING THE PLASMA-MEMBRANE ANCHORING DOMAIN
AXONAL SPROUTING INDUCED IN THE SCIATIC-NERVE BY THE AMYLOID PRECURSOR PROTEIN (APP) AND OTHER ANTIPROTEASES
ISOLATION OF PROTEOGLYCANS SYNTHESIZED BY RAT-HEART - EVIDENCE FOR THE PRESENCE OF SEVERAL DISTINCT FORMS
A COMPARISON OF THE XENOPUS-LAEVIS OOCYTE ACETYLCHOLINESTERASE WITH THE MUSCLE AND BRAIN ENZYME SUGGESTS VARIATIONS AT THE POSTTRANSLATIONAL LEVEL
CHARACTERIZATION OF ACETYLCHOLINESTERASE FROM HUMAN HEART AURICLES - EVIDENCE FOR THE PRESENCE OF A G-FORM SENSITIVE TO PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C
ASSOCIATION OF ACETYLCHOLINESTERASE WITH THE CELL-SURFACE
CARRAGEENANS SOLUBILIZE ASYMMETRIC ACETYLCHOLINESTERASE FROM NICOTINIC CHOLINERGIC SYNAPSES
DERMATAN SULFATE AND DE-SULFATED HEPARIN SOLUBILIZED COLLAGEN-TAILED ACETYLCHOLINESTERASE FROM THE RAT NEUROMUSCULAR-JUNCTION
Motor nerve regulates muscle extracellular matrix proteoglycan expression
PROTEOGLYCAN PRODUCTION IN DROSOPHILA EGG DEVELOPMENT - EFFECT OF BETA-D-XYLOSIDE ON PROTEOGLYCAN SYNTHESIS AND LARVAE MOTILITY
A SIMPLE ASSAY TO ESTIMATE THE ACETYLCHOLINESTERASE MOLECULAR-FORMS IN CRUDE EXTRACTS OF RAT SKELETAL-MUSCLE
ANTI-200 KDA NEUROFILAMENT ANTIBODY CROSS-REACTS WITH MICROTUBULE-ASSOCIATED PROTEIN-2 (MAP-2)
DISTRIBUTION AND ANCHORING OF MOLECULAR-FORMS OF ACETYLCHOLINESTERASE
NERVE REGULATION OF CLASS-I AND CLASS-II-ASYMMETRIC FORMS OF ACETYLCHOLINESTERASE IN RAT SKELETAL-MUSCLES
PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C SOLUBILIZED G2 ACETYLCHOLINESTERASE FROM PLASMA-MEMBRANES OF CHROMAFFIN CELLS
A 13 KDA FRAGMENT IS RESPONSIBLE FOR THE HYDROPHOBIC AGGREGATION OF BRAIN G4 ACETYLCHOLINESTERASE
A MEMBRANE-ASSOCIATED DIMER OF ACETYLCHOLINESTERASE FROM XENOPUS SKELETAL-MUSCLE IS SOLUBILIZED BY PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C
AXONS GROW IN THE AGING RAT BUT FAST TRANSPORT AND ACETYLCHOLINESTERASE CONTENT REMAIN UNCHANGED
CHANGES IN CONTRALATERAL SYNAPTIC ACETYLCHOLINESTERASE FOLLOWING MOTOR-NERVE SECTION IN RATS
Characterization of a tetrameric G4 form of acetylcholinesterase from bovine brain: a comparison with the dimeric G2 form of the electric organ
BIOSYNTHESIS OF THE NEUROFILAMENT HEAVY SUBUNIT IN XENOPUS OOCYTES MICROINJECTED WITH RAT-BRAIN POLY(A)+ RNA
CO-SOLUBILIZATION OF ASYMMETRIC ACETYLCHOLINESTERASE AND DERMATAN SULFATE PROTEOGLYCAN FROM THE EXTRACELLULAR-MATRIX OF RAT SKELETAL-MUSCLES
EFFECT OF PHENYTOIN ON CYTOSKELETAL PROTEIN-PHOSPHORYLATION AND NEURONAL STRUCTURE IN THE RAT SENSORY CORTEX
GLYCOSAMINOGLYCAN COMPOSITION OF ELECTRIC ORGAN BASEMENT-MEMBRANES
ISOLATION OF THE HEPARAN-SULFATE PROTEOGLYCANS FROM THE EXTRACELLULAR-MATRIX OF RAT SKELETAL-MUSCLE
SYNTHESIS AND EXPRESSION OF FUNCTIONAL ANGIOTENSIN-II RECEPTORS IN XENOPUS OOCYTES INJECTED WITH RAT-BRAIN MESSENGER-RNA
THE SENSORY PROJECTIONS OF DROSOPHILA MUTANTS WHICH SHOW ABNORMAL WING FORMATION OR FLYING BEHAVIOR
HEPARIN-ACETYLCHOLINESTERASE INTERACTION - SPECIFIC DETACHMENT OF CLASS I-A FORMS AND BINDING OF CLASS I AND CLASS-II-A FORMS TO HEPARIN-AGAROSE
PUTATIVE GLUTAMATE RECEPTORS IN MEMBRANES OBTAINED FROM HEADS OF DROSOPHILA-MELANOGASTER
The synaptic form of acetylcholinesterase binds to cell-surface heparan sulfate proteoglycans
THE SYNAPTIC FORM OF ACETYLCHOLINESTERASE BINDS TO CELL-SURFACE HEPARAN-SULFATE PROTEOGLYCANS
ANCHORAGE OF COLLAGEN-TAILED ACETYLCHOLINESTERASE TO THE EXTRACELLULAR-MATRIX IS MEDIATED BY HEPARAN-SULFATE PROTEOGLYCANS
ATYPICAL DISTRIBUTION OF ASYMMETRIC ACETYLCHOLINESTERASE IN MUTANT PC12 PHEOCHROMOCYTOMA CELLS LACKING A CELL-SURFACE HEPARAN-SULFATE PROTEOGLYCAN
INTERACTION OF HEPARIN WITH MULTIMOLECULAR AGGREGATES OF ACETYLCHOLINESTERASE
MEMBRANE-BOUND FORM OF ACETYLCHOLINESTERASE ACTIVATED DURING POSTNATAL-DEVELOPMENT OF THE RAT SOMATOSENSORY CORTEX
16S-ACETYLCHOLINESTERASE OF THE EXTRACELLULAR-MATRIX IS ASSEMBLED WITHIN MOUSE MUSCLE-CELLS IN CULTURE
ACETYLCHOLINESTERASE IS FUNCTIONAL IN EMBRYONIC RAT MUSCLE BEFORE ITS ACCUMULATION AT THE SITES OF NERVE MUSCLE CONTACT
Acetylcholinesterase is functional in embryonic rat muscle before its accumulation at the sites of nerve-muscle contact
ACYL-COA SYNTHETASE AND THE PEROXISOMAL ENZYMES OF BETA-OXIDATION IN HUMAN-LIVER - QUANTITATIVE-ANALYSIS OF THEIR SUBCELLULAR-LOCALIZATION
AGE-RELATED RESPONSES OF SKELETAL-MUSCLE AFTER ECTOPIC INNERVATION, WITH PARTICULAR REFERENCE TO 16S ACETYLCHOLINESTERASE, IN ADULT-RATS
BINDING OF THE ASYMMETRIC FORMS OF ACETYLCHOLINESTERASE TO HEPARIN
SUBCELLULAR-LOCALIZATION OF ACETYLCHOLINESTERASE MOLECULAR-FORMS IN ENDPLATE REGIONS OF ADULT MAMMALIAN SKELETAL-MUSCLE
THE ELECTRIC ORGAN OF DISCOPYGE-TSCHUDII - ITS INNERVATED FACE AND THE BIOLOGY OF ACETYLCHOLINESTERASE
DEVELOPMENTAL REGULATION OF 16S-ACETYLCHOLINESTERASE AND ACETYLCHOLINE-RECEPTORS IN A MOUSE MUSCLE-CELL LINE
HEPARIN SOLUBILIZES ASYMMETRIC ACETYLCHOLINESTERASE FROM RAT NEUROMUSCULAR-JUNCTION
INCREASE OF MUSCLE PEROXISOMAL ENZYMES AND MYOTONIA INDUCED BY NAFENOPIN, A HYPOLIPIDEMIC DRUG
NEURAL 16S ACETYLCHOLINESTERASE IS SOLUBILIZED BY HEPARIN
THE A12 ACETYLCHOLINESTERASE AND POLYPEPTIDE COMPOSITION OF ELECTRIC ORGAN BASAL LAMINA OF ELECTROPHORUS AND SOME TORPEDINAE FISHES
ANEURAL MUSCLE-CELL CULTURES MAKE SYNAPTIC BASAL LAMINA COMPONENTS
ASSOCIATION OF THE SYNAPTIC FORM OF ACETYLCHOLINESTERASE WITH EXTRACELLULAR-MATRIX IN CULTURED MOUSE MUSCLE-CELLS
GANGLIOSIDES AND SIALOGLYCOPROTEINS IN NORMAL AND DENERVATED RAT DIAPHRAGM MUSCLE
ACETYLCHOLINESTERASE AGGREGATES IN A NEWLY FORMED MOTOR-NERVE SMOOTH-MUSCLE JUNCTION
Cellular localization of the molecular forms of acetylcholinesterase in rat pheochromocytoma PC12 cells treated with nerve growth factor
Purification of the peroxisomal fatty acyl-CoA oxidase from rat liver
PURIFICATION OF THE PEROXISOMAL FATTY ACYL-COA OXIDASE FROM RAT-LIVER
ACETYLCHOLINESTERASE LIKE THAT OF SKELETAL-MUSCLE IN SMOOTH-MUSCLE RE-INNERVATED BY A MOTOR-NERVE
DETECTION OF PEROXISOMAL FATTY ACYL-COENZYME-A OXIDASE ACTIVITY
FATTY-ACID OXIDATION BY HUMAN-LIVER PEROXISOMES
PROPERTIES OF FATTY ACYL-COA OXIDASE FROM RAT-LIVER, A PEROXISOMAL FLAVOPROTEIN
EFFECT OF DENERVATION AND OF AXOPLASMIC-TRANSPORT BLOCKAGE ON INVITRO RELEASE OF MUSCLE ENDPLATE ACETYLCHOLINESTERASE
IS THERE A CORRESPONDENCE BETWEEN HALF-LIVES OF MOTOR ENDPLATE ACETYLCHOLINESTERASE AND JUNCTIONAL ACETYLCHOLINE RECEPTORS
ACTIN-LIKE FILAMENTS IN SYNAPTOSOMES DETECTED BY HEAVY-MEROMYOSIN BINDING
Muscle enzymatic changes induced by blockage of axoplasmic transport
ROLE OF AXOPLASMIC-TRANSPORT IN NEUROTROPHIC REGULATION OF MUSCLE END PLATE ACETYLCHOLINESTERASE
Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model.

Abstract (23)

The activation of the(Pro)renin receptor (PRR) stimulates fibrotic factors expression independent of b-catenin signaling pathway in collecting duct cells
Andrographolide activates the Wnt pathway and modulates the APP processing by direct inhibiton of GSK3 beta
Effect of hydrogen peroxide on apoptosis in Caenorhabditis elegans dopaminergic neurons
Activation of Brain Wnt signaling in vivo: Effect on LTP and Neurogenesis
Frizzled receptors mediate the postsynaptic effects of Wnt-5a in hippocampal neurons
Nicotine prevents synaptic impairment induced by A beta oligomers through alpha 7-nicotinic ACh receptor activation
Role of Wnt signaling in the postsynaptic development in hippocampal neurons
Anti-P Autoantibodies Enhance Cytosolic Calcium and Neurotransmission in Hippocampal Neurons by Cross-Reacting with Cell Surface NSPA
c-Abl inhibition decreases the levels of Amyloid beta peptide in plasma of Alzheimer transgenic mice.
Role of hippocampal P2X7 receptors in the release of NO by ATP and related nucleotides
Anti-P antibodies impair memory in mice
Peroxisomal proliferation prevents beta-amyloid-neurotoxicity in rat hippocampal neurons
AChE inhibitors, amyloid-induced neurotoxicity and the Wnt pathway
ApoER2 associates to different lipid rafts depending on the cell context and is endocytosed by a clathrin-mediated process involving Dab2
Selective M1 muscarinic agonists as potential disease modifiers for Alzheimer disease (AD)
The therapeutic potential of MI muscarinic agonists in Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA)
Ethanol specifically decreases PPAR beta MRNA and protein in B12 oligodendrocyte-like cells
Neuroprotective properties of copper binding fragments of amyloid precursor protein and prion
Neuroprotective properties of copper binding fragments of APP and PrP against copper toxicity
PPAR gamma activators induce differentiation of B12 oligodendrocyte-like cells and rat spinal cord oligodendrocytes
Regulation of prion protein gene expression by heavy metals
Acetylcholinesterase and beta-amyloid interactions
Amyloid-beta-peptide-acetylcholinesterase complexes and Alzheimer's disease

BiographicalItem (1)

In memoriam - Dr. Joaquin Luco Valenzuela - 1913-2002

BookSection (4)

Comprehensive overview of Alzheimer’s disease neurodegeneration, from amyloid-beta to neuroinflammatory modulation
PSD-95 (Postsynaptic Density Protein-95)
Inhibitory effects of β-amyloid aggregates on synaptic transmission in hippocampal neurons.
Zn 2+ -protein interactions in normal brain physiology and neuropathology.

BookWhole (5)

New discoveries on the hyperforin derivative, tetrahydrohyperforin: Closer to an Alzheimer'S disease treatment?
Monitoring mitochondrial membranes permeability in live neurons and mitochondrial swelling through electron microscopy analysis
Role of Alzheimer's ?-Amyloid on Wnt signaling
Las incomunicaciones del Alzheimer
Alzheimer’s Disease; Acetylcholinesterase Interaction with Alzheimer Amyloid β

ComunicacionBreve (1)

EL APORTE DE LUCO A LA NEUROCIENCIA CHILENA

ConferencePaper (7)

Deletion of the gene encoding for the enzyme Methionine sulphoxide reductase A increases the toxicity of A beta (1-42) in an in vivo model.
Effects of copper on A beta-induced pathological features in Caenorhabditis elegans.
Expression of Wnt receptors, frizzled, in rat neuronal cells
Acetylcholinesterase-amyloid-?-peptide interaction: Effect of Congo Red and the role of the Wnt pathway
Modulation of intracellular amyloid-beta-peptide aggregation by copper in Caenorhabditis elegans
Peroxisomal proliferation prevents beta-amyloid neurodegeneration
Molecular interactions of acetylcholinesterase with senile plaques

ConferencePoster (78)

Activation of Wnt signaling by Andrographolide reduces the neuropathology presented in a model of sporadic Alzheimer´s Disease
ANDROGRAPHOLIDE RECOVERS COGNITIVE IMPAIRMENT IN A NATuRAL MODEL OF ALzHEIMER’S DISEASE (OCTODON DEGUS)
ANDROGRAPHOLIDE RESTORE COGNITIVE PERFORMANCE IN AGED OCTODON DEGUS
Role of Wnt-5a on GluN2B expression
The non canonical ligand Wnt5a decreases mitochondrial motility and fusion in neuronal cells
Wnt signaling effects on differentiation and development of neural progenitor cells derived from adult hippocampu
WNT SIGNALING INHIBITION CORRELATES WITH AN INCREASE IN ALzHEIMER ́S NEuROPATHOLOGY IN A NATURAL MODEL (OCTODON DEGUS)
The diterpenes Ferruginol, Jatrophone and Junicedric acid as neuroprotective agents against Aβ oligomers-induced damage
The induction of hypothyroidism in early stagestriggers a decrease in the cognitive performance and hippocampus plasticity
The non canonical Wnt signaling modulates nitochondrial fusion in hippocampal neurons
The Wnt signaling pathways modulates mitochondrial fusion in hippocampal neurons
WNT SIGNALING PREVENTS MITOCHONDRIAL MEMBRANE PERMEABILITY INDUCED BY AMYLOID-BETA OLIGOMERS, THROUGH THE PERMEABILITY TRANSITION PORE INHIBITION IN HIPPOCAMPAL NEURONS
Wnt-3a metformin and rapamycin activity in the ampk-mTOR pathway in hippocampal neurons
Exo70 drives synaptogenesis and modulates dendrite morphology in dissociated hippocampal neurons
Frizzled- 1 receptor regulates neurogenesis in the hippocampus of adult mouse
Impact of the Wnt non-canonical signaling pathway on AMPA receptors synaptic enrichment
Inhibition of canonical Wnt Signaling induces an increase in the Aβ levels and cognitive impairment in both wild-type and J20 mice model of Alzheimer disease
Metabolic syndrome induces a specific cognitive failure and alteration in hippocampus activity
Mitochondrial structure alterations in Alzheimer's
Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons
The activation of the Wnt signaling modulates the function and mitochondrial dynamics in hippocampal neurons
THE GPCR RECEPTOR FRIZZLED-9 REGULATES DENDRITIC SPINE FORMATION GENERATED BY WNT-5A THROUGH G ALPHA O ACTIVATION
Transcriptional inhibitions of canonical Wnt signaling generate changes in the synapsis structure
Wnt pathway modulates glucose metabolism in neurons: Role in Alzheimer`s disease
Wnt-5a/Frizzled-9 regulates dendritic spine formation through Gαo and Gβγ stimulation
Wnt5a modulates mitochondrial distribution into synapses, regulating the dendritic spines morphology in hippocampal slices
Wnt5a modulates mitochondrial dynamics through Drp1 activation in hippocampal neurons
Wnt5a modulates the postsynaptic density of dendritic spines and the distribution of mitochondria to the synapse in neurons from hippocampal slices
Acute depletion of GSK-3 modulates lysosomal biogenesis leading to a reduction in amyloid precursor protein (APP) levels
Andrographolide activates the Wnt pathway and modulates the APP processing by direct inhibiton of GSK3β
Andrographolide increases cell proliferation and the generation of new neurons in the adult hippocampus
BDNF is expressed in a Wnt/β-catenin-dependent manner in hippocampal neurons and HT-22 cell line
Canonical Wnt/-catenin signaling stimulates the expression of fibrotic markers and triggers the disorganization of the primary cilium structure in MDCK cells
Chronic treatment of wild-type mice with high doses of methionine induces neurodegeneration
Lithium induces changes in the neuronal activity and distribution of the Wnt pathway components
Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation
Non-canonical Wnt signaling increases AMPA receptor clusters in hippocampal neurons
Octodon degu: brain evidence of the oxidative and metabolic stress age dependent related with Alzheimer-like pathology
Regional distribution of Wnt components can explain differential effect of Lithium along ventro-dorsal entorhinal-hippocampal axis
Regulation of PSD-95 palmitoylation and APT-1 expression by Wnt signaling pathways in hippocampal neurons
Role of canonical Wnt signaling in age-related neurodegeneration in the CNS of Octodon degu
Role of Gαi/0 activation in Wnt-5a non-canonical pathway and dendritic spine formation in hippocampal neurons
Role of the Wnt receptor Frizzled-1 in adult hippocampal neurogenesis
Role of Wnt-5a and Aβ in the GluN2B expression
Secreted Frizzled Related Protein-2 (sFRP2) is reduced during events of memory and learning, facilitating long-term depression (LTD) induction
Time-dependent control of ROCK2 and SYNGAP1 by Wnt5a in hippocampal neurons
Wn5a ligand activates the mitochondrial fission protein Drp1 in hippocampal neurons
Wnt-5a acts through G!i/0 to regulate dendritic spine formation in hippocampal neurons
Wnt/Ca2+ signaling pathway modulates mitochondrial dynamics in hippocampal neurons
Wnt3a ligand prevents mitochondrial permeability transition pore opening induced by Aβ oligomers
Wnt5a regulates expression of ROCK2 and SYNGAP1 through Mir-101b in rat hippocampal neurons
Andrographolide activates the Wnt pathway and modulates the APP processing possibly by direct inhibition of GSK3β
Angiotensin II induces fibrosis in kidney tubule-epithelial cells via Wnt/beta-catenin signaling pathway
Chronic hypoxia and tetrahydrohiperforin stimulates hippocampal neurogenesis in a mice model of Alzheimer’s disease
Fine tuning of Wnt signaling pathways in spontaneous network activity in the entorhinal hippocampal loop
Frizzled receptors in progenitor and immature neurons of the adult hippocampus
PSD-95 suppresses dendritic arbor development in mature hippocampal neurons by occluding synaptic insertion of NR2B-NMDA receptors
Wnt pathways modulate the α-7 nA ChR activities in hippocampal neurons and protect neurons from Aβ oligomers
Wnt-5a modulates the balance of metaplasticity in hippocampal CA1 mice
Wnt5a regulates microRNAs in hippocampal neurons
“(Pro) renin receptor stimulates the expression of fibrotic genes in  mouse collecting ducts cells via Wnt/β-catenin signaling, independently of Angiotensin II
Activation of Wnt Signaling Pathway Prevents AB Oligomers Neurotoxicity
Angiotensin II Acts through the Wnt/b-catenin signalling pathway: implications for Fibrosis
Cellular and Neuronal Network Properties during Different Oscillatory Activities in a Model of Alzheimer’s Disease
Copper treatment ameliorates neuromuscular synaptic defects in a Caenorhabditis elegans model of Inclusion Body Myositis
Disabled-2 modulates the Wnt signalling pathway and dendritic development in neurons
Enhance excitatory neurotransmission in hippocampal slices by anti-P autoantibodies from a patient systemic lupus
Hypoxia induces the Wnt/βcatenin pathway and in a mice model of Alzheimer´s disease increases adult hippocampal neurogenesis
IDN5706, a semi-synthetic derivative of hyperforin, increases adult hippocampal neurogenesis and long‐term memory in mice
Nicotine prevents synaptic impairment induced by Ab oligomers through alpha7-Nachr activation
Oxidative stress induces loss of GFP labeled neurons and delayed development to adulthood in an Unc-13 mutant
Peroxisome proliferators decrease synaptic plasticity failure and neurodegeneration APPswe/PSEN1 E9 mouse model of Alzheimer´s disease
Role of oxidative stress in the neuronal damage induced by Ab fibrils
Study of cellular and neuronal network properties during different oscillatory activities in a model of Alzheimer-disease
Tetrahydrohyperforin prevents cognitive failure in double transgenic mice model of Alzheimer´s disease with activation of TRPC6 channel as a possible mechanism
Wasp-1 protects against Ab oligomers-induced synaptic impairments through Wnt signalling pathway activation
Wnt signaling in neural development and synaptic function
β amyloid dodecamers and hiperphosphorylated Tau correlates with synaptic and cognitive impairments in aged Octodon degus

Editorial (1)

Special series on trending themes in Neurobiology in Biological Research

EditorialMaterial (2)

Contributions by researchers of "Ciencia de Frontera" of the Chilean Academy of Sciences
Copper promotes the formation of short neurotic beta-amyloid fibrils

Errata (3)

Publisher Correction: Non-canonical function of IRE1? determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics (Nature Cell Biology, (2019), 21, 6, (755-767), 10.1038/s41556-019-0329-y)
Identification of Cerebral Metal Ion Imbalance in the Brain of Ageing Octodon degus(vol 9, 66, 2017)
beta-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats (vol 2015, 726012, 2015)

Note (1)

Tetrahydrohyperforin (IDN5706) targets the endoplasmic reticulum for autophagy activation: Potential mechanism for Alzheimer’s disease therapy

Patent (3)

Beta-amyloid-directed multitarget compounds for the treatment of Alzheimer’s disease
A three compound mixture improving cognitive capacity
Andrographolide as an inhibitor of GSK-3beta for Alzheimer disease and to stimulate Neurogenesis

Proyecto (28)

WNT SIGNALING REGULATES DENDRITIC SPINES THROUGH THE ACTIVATION OF THE SMALL RHO GTPASES FAMILY
MOLECULAR BASIS OF THE SYNAPTIC FUNCTION OF WNT5A=> DENDRITIC SPINES AND BEHAVIOR
LOSS OF WHITE MATTER INTEGRITY AS AN EARLY BIOMARKER AND PATHOLOGICAL EVENT IN ALZHEIMERS DISEASE A NEUROIMAGING AND ANIMAL/CELLULAR MODEL STUDY
POTENTIAL THERAPEUTIC EFFECT OF THE BIS(THIOSEMICARBAZONES)-COPPER COMPLEXES IN THE COPPER HOMEOSTASIS DYSREGULATION IN ALZHEIMER DISEASE=> UNDERSTANDING OF THEIR NEUROPROTECTION MECHANISM.
POTENTIAL THERAPEUTIC EFFECT OF THE BIS(THIOSEMICARBAZONES)-COPPER COMPLEXES IN THE COPPER HOMEOSTASIS DYSREGULATION IN ALZHEIMER DISEASE=> UNDERSTANDING OF THEIR NEUROPROTECTION MECHANISM.
STUDY OF THE RELATIONSHIP BETWEEN WNT SIGNALING AND GLUCOSE MEBOLISM IMPAIRMENT IN THE COGNITIVE FAILURE OF ALZHEIMERS DISEASE MODELS
UPREGULATION OF GLUN2B SUBUNIT OF NMDA RECPTORS IN THE POR-OXIDANT OUTCOM IN ALZHEIME´S AND THE PUTATIVE PROTECTIVE ROLE OF WNT
WNT SIGNALING EFFECTS ON SYNAPTIC STRUCTURE AND FUNCTION=> ITS ROLE IN NEUROPROTECTION AGAINST THE AMYLOID-BETA PEPTIDE
DISCOVERY OF NEURONAL ROLES FOR GENES THAT CAUSE LETHALITY IN C.ELEGANS USING RNA INTERFERENCE.
Center For Cell Regulation and Pathology
MECANISMOS QUE REGULAN LA DIFERENCIACION TERMINAL DEL MUSCULO ESQUELETICO DURANTE EL DESARROLLO Y LA REGENERACION MUSCULAR.
EL ESTRES OXIDATIVO EN EL ORIGEN Y DESARROLLO DE LA ENFERMEDAD DE ALZHEIMER
REGULACION DE LA ESTRUCTURA DEL AXON POR AGENTES LOCALES
LA GLIA EN LA GENERACION Y NEUROTOXICIDAD DE LOS AGREGADOS DE B-AMILOIDE EN LA ENFERMEDAD DE ALZHEIMER=> SU ESTUDIO Y DISENO DE UN POSIBLE INSTRUMENTO DIAGNOSTICO DE LA POBLACION SUSCEPTIBLE
ROL DE LA ACETILCOLINESTERASA EN LA FORMACION DE FIBRAS DE AMILOIDE
FUNCION DE LOS PROTEOGLICANES DE HEPARAN SULFATO DE SUPERFICIE, DURANTE LA MIOGENESIS
INTERACCION ENTRE CELULA DE SCHWANN Y AXON=> REGULACION MUTUA POR PROTEASAS EXTRACELULARES.
POSIBLE PAPEL DE LA ACETILCOLINESTERASA EN EL PROCESAMIENTO EXTRACELULAR DE LA PROTEINA PRECURSORA DEL AMILOIDE Y SU IMPORTANCIA EN LA ENFERMEDAD DE ALZHEIMER
PAPEL DE LOS PROTEOGLICANES EN LA FORMACION DE LA PLACA NEURITICA, EL CRECIMIENTO NEURONAL Y EL EVENTUAL DIAGNOSTICO DE LA ENFERMEDAD DE ALZHEIMER.
PROCESAMIENTO DE LA PROTEINA PRECURSORA DEL AMILOIDE=> PRODUCCION DEL PEPTIDO -BETA A4 EN LA ENFERMEDAD DE ALZHEIMER
NEUROTROFISMO DE SUBSTANCIAS CON ACTIVIDAD ANTIPROTEASICA, INCLUYENDO LA PROTEINA PRECURSORA DE B-AMILOIDE DE LA ENFERMEDAD DE ALZHEIMER
ENFERMEDADES DE ALZHEIMER=> MARCADORES SISTEMATICOS Y SU UTILIZACION EN EL DIAGNOSTICO
BIOTECNOLOGIA DEL MANEJO DE LARVAS DE LOCO=> INDUCTORES DE ASENTAMIENTOS Y HORMONAS DE CRECIMIENTO.
REGENERACION DEL NERVIO PERIFERICO=> ACELERACION POR FACTOR DE CRECIMIENTO.
MORFOGENISIS Y DIFERENCIACION CELULAR AL COMIENZO DEL DESARROLLO DE MAMIFEROS.
SINTESIS Y EXPRESION DE RECEPTORES DE ANGIOTENSINA II CEREBRALES EN OOCITOS DE ENOPUS LAEVIS=> CLONAMIENTO Y SEGUNDOS MENSAJEROS.
ASOCIACION DE LA ACETILCOLINESTERASA GLOBULAR A LA MEMBRANA NEURONAL Y SU EXPRESION EN OOCITOS DE XENOPUS LAEVIS.
POTENTIAL THERAPEUTIC EFFECT OF THE BIS(THIOSEMICARBAZONES)-COPPER COMPLEXES IN THE COPPER HOMEOSTASIS DYSREGULATION IN ALZHEIMER DISEASE: UNDERSTANDING OF THEIR NEUROPROTECTION MECHANISM.

Review (43)

Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model
Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimers disease
Wnt Signaling in the Central Nervous System: New Insights in Health and Disease
Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer's disease
Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer’s Disease?
Environmental control of microRNAs in the nervous system: Implications in plasticity and behavior
P2C-Type ATPases and Their Regulation
Role of Wnt Signaling in Central Nervous System Injury
Accelerating Alzheimer's research through 'natural' animal models
How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario
Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-beta brain balance and the putative role of PPARs
Brain metabolite clearance: impact on Alzheimer's disease
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
Metal and complementary molecular bioimaging in Alzheimer's disease
Signaling pathway cross talk in Alzheimer's disease
Wnt signaling in the nervous system and in Alzheimers disease
Peroxisome Proliferator-activated Receptors and Alzheimer's Disease: Hitting the Blood-Brain Barrier
WNT signaling in neuronal maturation and synaptogenesis
Wnt signaling in the regulation of adult hippocampal neurogenesis
Wnt signaling: Role in LTP, neural networks and memory
Wnts in adult brain: from synaptic plasticity to cognitive deficiencies
Postsynaptic receptors for arnyloid-beta oligomers as mediators of neuronal damage in Alzheimer's disease
Recent rodent models for Alzheimer's disease: clinical implications and basic research
Wnt Signaling: Role in Alzheimer Disease and Schizophrenia
Interactions of AChE with A beta aggregates in Alzheimer's brain: therapeutic relevance of IDN 5706
Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease
Emerging roles of Wnts in the adult nervous system
Neurobiological effects of hyperforin and its potential in Alzheimer's disease therapy
Wnt Signaling Modulates Pre- and Postsynaptic Maturation: Therapeutic Considerations
Amyloid-cholinesterase interactions - Implications for Alzheimer's disease
Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle
Structure-function implications in Alzheimer's disease: Effect of a oligomers A beta central synapses
The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease
Wnt signaling in neuroprotection and stem cell differentiation
Role of copper in prion diseases: Deleterious or beneficial?
Acetylcholinesterase interaction with Alzheimer amyloid beta.
Copper brain homeostasis: Role of amyloid precursor protein and prion protein
Is there a role for copper in neurodegenerative diseases?
Trolox and 17 beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway
An overview of the current and novel drugs for Alzheimer's disease with particular reference to anti-cholinesterase compounds
Structure and function of amyloid in Alzheimer's disease
The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease
Wnt signaling function in Alzheimer's disease
497
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

38
Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

31
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

22
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

21
Juan Zolezzi

Associate Professor

School of Medicine

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

13
Alicia Nogueras

Profesor Asociado Adjunto

Departamento de Biología Celular y Molecular

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

13
Marcelo Chacon

Postdoc

Neurology

UTHealth

Houston, Estados Unidos

13
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

12
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

11
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

11
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

11
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

10
Rebeca Aldunate

Profesor Titular

Ciencias

UNIVERSIDAD SANTO TOMÁS

Santiago, Chile

9
Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

9
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

8
Maria Barria

Assistant Professor

Departamento de Microbiologia

Universidad de Concepción

CONCEPCION, Chile

8
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

8
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

6
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

6
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

6
Juvenal Rios

Subdirector Observatory of Health Innovation

Colegio Médico de Chile A.G.

Santiago, Chile

6
DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

5
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

5
Carolina Oliva

Investigador Asociado

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

5
Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

5
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

5
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

5
Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

5
Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

4
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

4
Patricia Burgos

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

4
Rodrigo Assar

Adjoint Professor

Facultad de Medicina

Universidad de Chile

Santiago, Chile

4
Christian Hodar

ASSISTANT PROFESSOR

BIOINFORMATICS & GENEXPRESSION LAB - INTA

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

4
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

4
Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

3
PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

3
Andreas Schüller

Assistant Professor

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

3
Fabián Segovia

Assistant professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

3
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

3
Gonzalo Olivares

ASSISTANT PROFESSOR

NEUROCIENCIA

Universidad de Chile

SANTIAGO, Chile

3
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

3
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

3
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
Karen Fuenzalida

Encargado de confirmación diagnóstica de Errores Innatos del Metabolismo (EIM) mediante técnicas GCMS y LCMSMS

Instituto de Nutrición y Tecnología de Alimentos

Universidad de Chile

Santiago, Chile

3
ricardo fadic

Jefe de Division

Division de Neurociencias

DEPARTAMENTO DE NEUROLOGÍA, FACULTAD DE MEDICINA, P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Jose Garrido

Investigador Asociado

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

3
Alejandro Roth

Profesor Asistente

DEPARTAMENTO DE BIOLOGÍA,

DEPARTAMENTO DE BIOLOGÍA, FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

3
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

3
Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

2
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

2
Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile

2
Servet Martinez

Full professor

Mathematical Engineering

Universidad de Chile

Santiago, Chile

2
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

2
Diego Mezzano

Director

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Viviana Cavieres

Postdoctoral Researcher

Medicina y Ciencias

Universidad San Sebastián

Santiago , Chile

2
Sussy Bastías

Profesor Asociado

Universidad de Magallanes

Punta Arenas, Chile

2
Ricardo Matute

Associate Professor

Centro Integrativo de Biología y Química Aplicada (CIBQA)

Universidad Bernardo O'Higgins

Santiago , Chile

2
Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

2
Luis Larrondo

Associate Professor

Genetica Molecular y Microbiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Alejandro Maass

Director

Center for Mathematical Modeling

Universidad de Chile

Santiago, Chile

2
Macarena Arrázola

Postdoctorado

Universidad Mayor

Santiago, Chile

2
Veronica Cambiazo

Associate Professor

Unidad de Nutrición Básica

UNIVERSIDAD DE CHILE - INTA

Santiago, Chile

2
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

2
Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

2
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

2
Alexis Gonzalez

Adjunct Professor

Instituto de Química

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

2
Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

2
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

2
Salesa Barja

Médico Nutrióloga pediátrica

Gastroenterología y Nutrición Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

2
lisbell estrada

Decana Facultad Ciencias de la Salud

Facultad de Ciencias de la Salud

Universidad Bernardo O Higgins

santiago, Chile

2
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Rodrigo Aguilar

Assistant Professor

Institute for Biomedical Sciences

Universidad Andrés Bello

Santiago, Chile

1
Daniel Bunout

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Sandra Hirsch

planta

ECRAN

INTA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile

1
GONZALO MARDONES

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

1
romina cataldo

project manager

Direccion de Innovacion

Universidad de La Frontera

temuco, Chile

1
Lina Vargas

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Francisco Melo

Profesor Asociado

Genetica Molecular y Microbiologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

1
Pablo Muñoz

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Juan Agustín Larraín

Profesor Titular

Biologia Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Hector Bustos

Director

Capia

Universidad Santo Tomas

Puerto Montt, Chile

1
Noelia Escobedo

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

1
Patricio Fuentes

Medico Neurologo

Medicina

Hospital Clínico Universidad de Chile

Santiago, Chile

1
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Pablo Mardones

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Pablo Achurra

Cirujano Digestivo/ Instructor Adjunto

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

1
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

1
David Andrade

Profesor Asistente

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

1
Hugo Diaz

PhD

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Duxan Arancibia

Investigador Posdoctoral

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Oscar Lazo

Research Fellow

UK Dementia Research Institute and Department of Neuromuscular diseases

UCL Queen Square Institute of Neurology

London, Reino Unido

1
Felipe Bodaleo

Postdoctoral Researcher

Universidad de Chile

Santiago, Chile

1
Claudia Yefi

Assistant professor

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Hianara Bustamante

Profesor Adjunto Ad-Honorem

Instituto de Microbiología Clínica

Universidad Austral de Chile

Valdivia, Chile

1
Katherin Pereyra

Instructor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Octavio Monasterio

Profesor Titular

Departamento de Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

1
Genevieve Merabachvili

Profesor Asistente

salud

Universidad Santo Tomás

Santiago, Chile

1
Aldo Villalon

Director Académico/Profesor Asistente

Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Fernando Cruzat

Profesor Asociado

Oceanografia

Universidad de Concepción

Concepción, Chile

1
Carla Trigo

postdoctorante

Quimica y Biologia

Universidad de santiago de chile

santiago, Chile

1
Joaquìn Araya

Profesor

Facultad de Salud

Universidad Santo Tomás

Santiago, Chile

1
Claudio Allard

PROFESOR ASISTENTE

Química y Biología

Universidad de Atacama

Copiapó, Chile

1
Gonzalo Cancino

Assistant Professor

Facultad de Ciencias

Universidad Mayor

Santiago, Chile

1
Paula Slater

Postdoctoral researcher

Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudia Metz

Docente Investigador

Universidad San Sebastián

Santiago, Chile

1
Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

1
Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

1
Patricio Ramos

academico

Instituto de ciencias biológicas

UNIVERSIDAD DE TALCA

Talca, Chile

1
ADRIAN GONZALEZ

Postdoc

Biologia celular

Pontificia Universidad Católica de Chile

Santiago de Chile, Chile

1
Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

1
Gonzalo Cabrera

Academic

Cell and Molecular Biology

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

1
Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

1
Francisco Bozinovic

Full professor

Ecology

Pontifical Catholic University of Chile

Santiago, Chile

1
Juan Montiel

Profesor Titular

FACULTAD DE MEDICINA

UNIVERSIDAD DIEGO PORTALES

Santiago, Chile

1
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Macarena Rojas

Directora Ejecutiva

Centro de Gerociencia, Salud Mental y Metabolismo, GERO

Santiago, Chile

1
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

1
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Matias Campos

Business Developer

Fundación LEITAT Chile

Santiago, Chile

1
Gladys Tapia

Academica

Farmacología Molecular y Clínica

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

1
Rocío Retamales

Docente

Facultad de Ciencias Agropecuarias

Universidad Pedro de Valdivia

Santiago, Chile