Man

Francisca Verónica Bronfman Cáceres

Full Professor

Universidad Andrés Bello

Santiago, Chile

Líneas de Investigación


1-We studied the signaling mechanisms allowing neuronal growth, survival and plasticity by neurotrophic factors. 2-We are also interested in studying functional lipids derived from seaweeds to prevent, mitigate, or treat non-communicable diseases.

Educación

  •  PhD in Medical Sciences, Catholic University of Leuven (KUL). Bélgica, 2000
  •   Degree (5 years studies) in Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1993

Experiencia Académica

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Biological Sciences

    Santiago, Chile

    2009 - 2019

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    School of Biological Sciences

    Santiago, Chile

    2002 - 2009

  •   Postdoctoral Training Other

    Weizmann Institute of Science

    Rehovot, Israel

    2000 - 2003

  •   Visiting scientist Other

    Max Plank Institute

    Goettingen, Alemania

    2000 - 2000

  •   Visiting scientist Other

    Catholic University of Leuven

    Leuven, Bélgica

    2003 - 2003

  •   Visiting scientist Other

    Weizmann Institute of Science

    Rehovot, Israel

    2006 - 2006

  •   Honorary Senior Lecturer Other

    University Colleage London

    London, Reino Unido

    2016 - 2017

  •   Profesor Titular Full Time

    Universidad Andres Bello

    Facultad de Medicina

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Assistant Professor Full Time

    P. Catholic University of Chile

    Santiago, Chile

    2000 - 2009

  •   Associate Professor Full Time

    P. Catholic University of Chile

    Santiago, Chile

    2009 - 2019

  •   Full Professor Full Time

    Universidad Andrés Bellos

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


UNDERGRADUATE THESIS DIRECTION AND PROFESSIONAL QUALIFICATIONS (INCLUDING THE MASTER'S DEGREE)

Running. Student's name, title and date of the defense / procurement

Victor Barraza. Biochemistry undergraduate. University of Chile Antioxidant activity of botanical extract derived from Agarophyton chilensis. Started; August, 2017

Finished. Student's name, title and date of the defense / procurement

1-Paulina Covarrubias. Research training to get a Bachelor degree in Biology (Bio -296). Catholic University of Chile. School of Biological Sciences. Department of Physiology. "Proteolytic processing of the p75 neurotrophin receptor in PC12 cells." July 2005.

2-Oscar Lazo. Research training to get a Bachelor degree in Biology (Bio -296). Catholic University of Chile. School of Biological Sciences. Department of Physiology. Axotomy of the septo- hippocampal pathway induces the loss of the cholinergic phenotype in cells of the medial septum per no neuronal death. December 2005.

3-Edgardo Allende. Undergraduate thesis (Biochemistry). Catholic University of Chile. School of Biological Sciences. Department of Physiology. "ADAM17 and its role in neurotrophic signaling. March 2007-December 2008 (did not handle the manuscript).

4-Carolina Cabeza. Research training to get a Bachelor degree in Biology (Bio -296). Catholic University of Chile. School of Biological Sciences. Department of Physiology. " PC12 Cells - U18666A. A model to study the cellular phenotype of Niemann Pick Type C". December 2008.

5-Elisabeth Medina. Research training to get a Bachelor degree in Biology (Bio -296). Catholic University of Chile. School of Biological Sciences. Department of Physiology" Signs dependent BDNF Rab11 -deficient neurons." December 2009.

6-Alicia Figueroa. Undergraduate thesis (Biochemistry). Catholic University of Chile. School of Biological Sciences. Department of Physiology. "Neurotrophic signaling in the cholinergic system of Mice null for NPC II". April 2010.

7-Jose Ignacio Parraguez. Undergraduate thesis (Biochemistry). Catholic University of Chile. School of Biological Sciences. Department of Physiology. "Molecular Determinant of internalization and endocytic trafficking Neurotrophin receptor p75" May 2010.

8-Claudia Pissani. Undergraduate thesis (Biochemistry). Characterization of the neuroprotective effects of two agonists of PPARgamma in a cortical focal stroke model in rat. May 2012.

9-Jorge Larios. Undergraduate thesis (Biochemistry). Catholic University of Chile. School of Biological Sciences. Department of Cell and Molecular Biology. Cross-talk signaling between neurotrophins and Reelina/ApoER2 system (co -advisor). Advisor Dr Maria Paz Marzolo. June 2012.

10-Valentina Contreras. Undergraduate thesis (Biochemistry). Catholic University of Chile. School of Biological Sciences. Department of Physiology. "Venlafaxine Regulates the Expression of BDNF, FGF2 and TGFbeta in a model of cortical stroke”. Finished 23th May 2014.

11-Carla Gonzalez. Undergraduate thesis (Biotechnology). Study of Rab11 phosphorylation induced by TrkB receptor in HEK293 cells. Mayor University. Finished, 7th December 2016.

12-Pedro Picker. Undergraduate thesis (Biochemistry). Phosphorylation of the intracellular domain of the p75 neurotrophin receptor. Catholic University of Chile. Finished, 18th May 2017.

13-Diego Villegas Research Seminar, Bio296. Techniques for quantification and measurement of stroke in mice. Biological Sciences Faculty. Catholic University of Chile. First semester, 2018.

14-Nicolas Stuardo. Undergraduate thesis (Biochemistry). "Generation and validation of monobiotinylated AviTag BDNF for studies of its endocytic traffic" Faculty of Biological Sciences. Catholic University of Chile. Completed July 18, 2019.

15-Diego Zavala. Undergraduate thesis (Biochemistry). "Dilucidating the mechanism of regulation of the expression of the PPARgamma transcription factor by BDNF in cortical neurons in primary culture. Possible dependence on the CREB transcription factor". Faculty of Chemistry and Biology. University of Santiago, Chile. October 11, 2019.

DIRECTION OF GRADUATE THESIS (only PhD)

Running.

Carolina Cabeza. PhD in Biological Sciences. Physiology programme. Pontifical Catholic University of Chile. Thesis project approved “Rol of the endocytic system in the apoptotic signaling mediated by p75 neurotrophin receptor in sympathetic neurons” Started, October 2014-2021. Presenting her final manuscript and exam

America Chandía (co-advisor with Dr Alejandra Alvarez). PhD in Biological Sciences. Cellular and Molecular Biology programme. Pontifical Catholic University of Chile. Thesis project approved “The tyrosine kinase c-Abl prevents the traffic of TrkB receptor to the degradative route in response to BDNF. Presenting her final manuscript and exam.

Completed. Student's name, title and date of the defense / procurement

1-Maria Soledad Urra. PhD in Biological Sciences. Cellular and Molecular Biology programme. Pontifical Catholic University of Chile. "Molecular and Cellular Regulation of p75 Proteolytic Processing". Finished, November 13th, 2009.

2-Oscar Marcelo Lazo. PhD in Biological Sciences. Physiology programme. Pontifical Catholic University of Chile. "The traffic on Route TrkB receptor recycling regulated by Rab11 is necessary for BDNF -induced dendritic branching in hippocampal neurons in low density". Finished June 10th, 2011.

3-Claudia Escudero. PhD in Biological Sciences. Physiology programme. Pontifical Catholic University of Chile. "Functional role of internalization and retrograde transport of p75 neurotrophin receptor" 20th August, 2012.

4-Rodrigo Zepeda. Doctor of Science with a major in Neuroscience. Valparaiso University. “Role of venlafaxine and hyperforin in functional recovery and neuronal plasticity induced focal ischemia in rat motor cortex”. April 16th, 2013.

5-Andrés Gonzalez. PhD in Biological Sciences. Mention Physiology. Pontifical Catholic University of Chile. “The early-recycling pathway regulates genetic expression an activation of the transcription factor CREB required for the dendritic arborisation induced by BDNF”. 16th May, 2016.

6-Juan Pablo Lezana. PhD in Biological Sciences. Cellular and Molecular Biology programme. “PPAR? promotos neuronal growth and regeneration in the nervous system”. 24th July 2017.

7-Claudia Pissani. PhD in Biological Sciences. Physiology programme. Pontifical Catholic University of Chile. Effect of a botanical extract, which has PPAR? activators, on ischemic injury and motor impairment of rats subjected to cortical focal ischemia. 14th May, 2018.

8-Guillermo Moya-Alvarado. PhD in Biological Sciences. Physiology programme. Pontifical Catholic University of Chile. Mechanism of long-distance control of dendritic growth by Brain-Derived Neurotrophic Factor in central neurons. 3th December, 2019.

POST - DOCTORAL TRAINING.

1-Carlos Flores. PhD in Cellular and Molecular Biology. Austral University of Chile. Start (August 2008- August 2012).

2-Oscar Lazo. PhD in Biological Sciences. Program of Physiology. Pontifical Catholic University of Chile (August 2011 -March 2014).

3-Claudia Escudero. PhD in Biological Sciences. Program of Physiology. Pontifical Catholic University of Chile (August 2012 -January 2014).

4-Bernardita Cádiz. PhD in Neuroscience. University of Valencia. Started, August 2016.

5-Raquel Ibañez. PhD in Biological Sciences. Cellular and Molecular Biology Programme. Pontifical Catholic University of Chile. Started, March 2017-

6-Karen Fuenzalida. PhD in Biological Sciences. Cellular and Molecular Biology Programme. Pontifical Catholic University of Chile. Karen has worked part-time as a researcher associated in different projects in my laboratory (Basal Funds, FONDEFidea, Corfo). Start, March 2015-present.

7-Viviana Perez. PhD in Biological Sciences, Cell Biology. University of Concepcion (UDEC). He won the Fondecyt postdoctoral 2019 competition in a project in collaboration with Prof Juan Pablo Henriquez.


Difusión y Transferencia


SYMPOSIA AND PRESENTATIONS

“p75 neurotrophin receptor trafficking and processing in the endocytic pathway”. Symposium “Neurotrophic factor signalling”. SBA, Biomedical Argentinian Society Conference. Mar del Plata. Buenos Aires. 20th, November 2004. Invited speaker.

“p75 neurotrophin receptor trafficking and processing in the endocytic pathway”. Workshop on RNA Control of Neuronal Function, Kfar Blum, Israel. Clues for axonal retrograde signaling. May 22- 26, 2005. Oral presentation.

“p75 neurotrophin receptor trafficking and processing in the endocytic pathway”. Gordon Conference for Neurotrophic Factors, Salve Regina University, US. June 19-24, 2005. 19-24 de Junio 2005. Oral presentation.

“p75 neurotrophin receptor trafficking and processing in the endocytic pathway” Organization and participation in the symposium "Signaling mediated by neurotrophic factors. Molecular, cellular and physiological aspects”. First Annual Meeting of the Chilean Society for Neuroscience. December 2005. Oral presentation.

“p75 Neurotrophin Receptor processing in Endosomes: New Clues for Retrograde Signaling?” Symposium and Workshop in “Molecular and Cellular Basis of Neuroconectivity”. 4-6th May, Leuven, Belgium, 2006. Invited speaker.

“p75 neurotrophin receptor processing and trafficking in neuronal endosomes; new clues for p75 neuronal signalling”. EMBO/FEBS/ISF Workshop on system dynamics of intracellular communication –overcomming distances in signaling networks. Maale Hachamisha, Jerusalem Hills, Israel. 18-22th, March, 2007. Oral presentation.

“p75 neurotrophin receptor processing and trafficking in neuronal endosomes; new clues for p75 neuronal signalling”. Symposium of Neurobiology of Brain Development, organized by the Center of Neurobiology and Plasticity. Valparaiso University. Valparaiso, Chile. 31th August, 2007. Invited speaker.

“BDNF-Induced dendritic arborization is regulated by the Rab11 monomeric GTPase in hippocampal neurons”. EMBO/FEBS/ISF Workshop on system dynamics of intracellular communication –overcomming distances in signaling networks. Maale Hachamisha, Jerusalem Hills, Israel. 15-19th March 2009. Oral presentation.

Discussion Leader at the “Gordon Conference for Neurotrophic Factors”, Salve Regina University, USA. 21-26th June 2009.

“Axonal Retrograde Killing by Neurotrophins”. Symposium "Axonal Cell Biology and Regeneration" at the XXV Annual meeting of the Chilean society for cell biology. 1-5th November, Puerto Varas, Chile. 2011. Organization and speaker.

“Neurotrophic Factors and Neurodegeneration”. Symposium. VI Congreso Iberoamericano de Alzheimer. October 18-20th. 2012. Santiago. Chile. Invited speaker.

“Bad news from the axon: Role of p75 neurotrophin receptor in retrograde killing”. The 20th TEL-AVIV University Alzheimer's Disease Conference. Symposium. June 27-28th. 2012. Tel Aviv, Israel. Invited speaker.
“BDNF regulates rab11-mediated endosome dynamics to induce dendritic branching”. EMBO Conference. Spatial 2013: From spatial signaling to sensing spatiality. Symposium on spatial signaling in neurons. 24-28 April. Dead See. Israel. Oral presentacion.

“BDNF-induced activation of the c-Jun amino terminal kinase regulates the generation of a retrograde apoptotic signaling endosome containing p75 neurotrophin receptor in sympathetic neurons”. American Society for Cell Biology. 14-18th December, 2013, New Orleans, Louisiana, USA. Selected for e-poster talk.

“Death signaling endosomes in neuronal axons containing the common neurotrophin receptor. implication for neurodegenerative diseases. 4th International Conference of Young Scientists & Annual General Meeting of the Global Young Academy. 22th May, 2014, Santiago, Chile. Short talk. Invited Speaker.

“Role of the endocytic system in BDNF-mediated dendritic branching”. Participation in Simposium I: “The god and the bad of neurotrophins” at the XXIX annual meeting of the Argentian Society of Neuroscience (SAN). 1st of October, 2014. Invited Speaker.

Organization of Symposium and Chair. “Vascular Development and Function” XXIX Annual Meeting of the Sociedad de Biología Celular de Chile. Puerto Varas, Chile. 25-29th October, 2014.
“Contribution of the endocytic pathway to BDNF-induced dendritic branching and signalling” (session 6). CiSNe Summer Symposium in Biophysics and Neurobiology. From single molecules to complex multicellular organism. Valdivia. Chile. 6-9th January de Enero, 2015. Invited Speaker.

“c-Jun N-terminal kinase regulates p75 internalization leading to retrograde axonal transport of apoptotic signaling endosomes”. Symposium on long-distance control of the transcriptomic and proteomic responces to neuronal injury (S37). 25th meeting of the international society for neurochemistry (ISN). Cairns, Australia. 23-27th August, 2015. Invited Speaker.
“Axonal BDNF promotes local synthesis and retrograde transport of the transcription factor PPARgamma in an mTOR depdent manner”. Keystone meeting. Axons: from cell biology to pathology. Santa Fe, New Mexico, US. 24-27th January 2016. Oral presentation.

“Reciprocal regulation of neurotrophin signaling and endosomal Rab GTPases to increase dendritic branching. From dendrites to the nucleus”. EMBO WORKSHOP Actualizations in Membrane Trafficking in Health and Disease. La Serena, Chile. 4-9th September 2016. Invited Speaker.

“PPARgamma function in the nervous system and a molecular target for natural drugs inducing neuroprotection”. Symposium. XXX Annual Meeting of Cellular Biology Society of Chile. Puerto Varas. 23-26th October 2016. Invited Speaker.
Discussion Leader at the “Gordon Conference for Neurotrophic Factors”, Salve Regina University, USA. 4-9th June 2017.

“Role of signaling endosomes and long-distance signaling in BDNF-mediated dendritic arborization” Symposium “Molecular Biology of the Neuron. Local versus long-distance signaling”. LXI Annual Meeting of the Biology Society of Chile. Puerto Varas, 20-22th November, 2018. Organization and participation.

Discussion Leader at the “Gordon Conference for Neurotrophic Mechanism in health and Diseases”, Salve Regina University, USA. 2-7th June 2019.

“Axonal BDNF/TrkB regulation of mTor-dependent local translation and dendritic branching in somas” Symposium (S07) on RNA control of axonal function. ISN-ASN meeting. Montreal, Canada. 4-8 th August, 2019. Invited Speaker.

SEMINARS or CONFERENCE PLENARY SESSIONS

National

“A close relation between signaling and trafficking in neurons. The case of neurotrophins”. Conference at the Faculty of Biological Sciences. Universidad Andrés Bello (UNAB). Santiago. Chile. 12th, May 2010. Invited speaker.

“Cellular processes regulating physiological function by neurotrophins. The case of signaling endosome”. Department of Physiology. Faculty of Biological Sciences. PUC. 24th de September, 2010. Departmental seminar. Invited speaker.

“Binding by Neurotrophins. Where, How and When? Molecular Interaction and Physiological Functions”. 80 years of Physiology at the PUC. Conference at Abate Molina. Casa Central. Faculty of Biological Sciences. PUC. 26th, Octubre, 2011. Invited speaker.

“Role of recycling endosomes in signaling and dendritic arborization induced by BDNF. From dendrites to the nucleus?” 18th June, 2014. Conference at the Faculty of Science, Universidad de Chile, Santiago, Chile. Invited speaker.

“Stroke and neuronal plasticity; importance for efective therapies”. Second round of seminar CEBIMA project. Room “Carlos Bance Conrads”. Hospital of Magallanes. 13 August 2015. Invited professor.

“Stroke and neuronal plasticity; importance for efective therapies”. Second round of seminar CEBIMA project. Room “Ernesto Livacic Gazzano”. University of Magallanes. 14 August 2015. Invited professor.

“BDNF regulates the endocytic system allowing the transcriptional control of dendritic growth”. Talks of the Institute of Biomedical Neuroscience (BNI). Institute of Biomedical Sciences. Faculty of Medicine. U Chile. 13th July 2016. Invited professor.

How do neurons regulate their morphology? Role of neurotrophins in protein translation
and transport of endosomes. Departamental Seminar. Department of Cellular and Molecular Biology. Faculty of Biological Sciences. P Catholic University. 12th July 2017. Invited professor.

INTERNACIONAL

“p75 neurotrophin receptor processing and trafficking in neuronal endosomes; new Clues for p75 neuronal signalling”. The second ISN Special Neurochemistry Conference Neuronal Glycoproteins and Glycolipids, Antigua, West Indies. 1-5, December, 2006. Invited speaker.

“A close relation between signaling and trafficking in neurons. The case of neurotrophins”. Molecular Neurobiology Forum. Weismann Institute of Science, Rehovot Israel. 8th of June 2010. Invited speaker.

“Jun N-terminal kinase regulates internalization to multivesicular bodies of the p75 neurotrophin receptor and retrograde apoptotic killing of sympathetic neurons”. Gordon Conference for Neurotrophic Factors, Salve Regina University, USA. 5-10th, June 2011. Invited speaker.

“Orchestrating neuronal morphology. Brain derived neurotrophic factor regulates recycling endosome dynamics to induce dendritic branching”. Weizmann Molecular Neuroscience Forum. Rehovot Israel. 26th, June 2012. Invited speaker
“BDNF regulates rab11-mediated endosome dynamics to induce dendritic branching”. Department of Cell Biology. University Medical Center. Groningen University. 22th April 2013. Invited speaker by Sven van Ijzendoorn.

“BDNF regulates Rab11-mediated recycling endosomal dynamics to induce dendritic branching and activation of the trascription factor CREB”. Emerging Concepts in Neuronal Cytoskeletom. 26-30th, May 2013. Marbella Resort, Maintencillo Chile. Invited speaker.

“Contribution of the endocytic pathway to BDNF induced dendritic branching”. CSHA / NGF 2014 joint conference on Nerve Growth Factor and Related Neurotrophic Factors: Emerging Concepts, New Mechanisms, Novel Technologies. 26th June Suzhou, China. Invited speaker.

“Contribution of the endocytic pathway to BDNF induced dendritic branching”. EMBO workshop: Current advances in membrane trafficking: Implications for polarity and diseases. 11th September, 2014. Puerto Natales, Chile. Invited speaker.
“Contribution of the endocytic system to BDNF-induced dendritic branching and signaling”. Emerging Concepts of the Neuronal Cytoskeleton. Puerto Varas, Chile. 22-26 March, 2015. Invited speaker.

“Contribution of the endocytic pathway to BDNF-induced dendritic branching and nuclear signaling”. Gordon Research Conference, Neurotrophic Factors. Salve Regina University, Newport, USA. 31 May-5 June, 2015. Invited speaker.

“Neurotrophins regulate the endosomal system and local translation of proteins for transcriptional control of dendritic growth” ALS Seminar. Sobell Department. Institute of Neurology University College London (UCL). March, 2017. Invited speaker.

“How do neurons control their morphology? Role of Neurotrophins in protein translation and endosomal transport” Randall Seminar. April 2017. King´s College London.UK. Invited speaker.

“How do neurons control their morphology? Role of neurotrophins in endosomal transport and protein translation” Molecular Neurobiology Forum. Weizmann Institute of Science. Rehovot. Israel. Invited speaker 19th June 2018.

“Role of signaling endosomes in BDNF-mediated local and long distance signaling and dendritic branching” Departmental seminar. Department of Pharmacology and Physiology. Sackler School of Medicine. Tel Aviv University.
Invited speaker 21th June 2018.

“Role of signaling endosomes in BDNF-mediated local and long distance signaling and dendritic branching” at the International Conference on Neurotrophic Factors (NGF2018), Salamanca, Spain. 23th June 2018. Invited speaker.

OUTREACH

Preparation of experimetal techniques to measure the activation of neurotrophins receptors. Latin American School of Neuroscience, IBRO 8-13 May 2006.

Organization and Participation in the Inter - University Course for graduate students " Theoretical and Experimental Course on Basic Principles in Wide Field and Confocal Microscopy " Conducted by Dr. Paul Maddox in the School of Biological Sciences (Room Abate Molina). 13-17 th Nov 2006.

Seminar at Alicante College of Maipu, "Molecular Motors and Neurodegenerative Diseases " October 6 th, 2005. EXPLORA Program from CONICYT.

Seminar at “Sacrago Corazón” College. "Molecular Motors and Neurodegenerative Diseases " October 6th, 2008. EXPLORA Program from CONICYT.

Seminar at the University of Antofagasta for post-graduate students. “Functional Role of internalization and proteolytic processing of neurotrophin receptors. University of Antofagasta. 10th July, 2009.

Small article in the magazine " Que Pasa". How neurotrophins transmit their signal in neurons?

Participation in the " Citizens' Forum " radio program. October 2009.

Article on the scientific career of Francisca Bronfman written by Nibaldo Inestrosa. In the Journal YA of the news paper “El Mercurio”. October 2009.

Participation as Guest Speaker at the XXVII National Congress of Students of biochemistry. A close relationship between trafficking and signaling of neurotrophin receptors". University of Antofagasta. August 7th, 2010.

Participation in Bio -Science Fair Organized by students of the Faculty of Biological Sciences (F.Bronfman) "Development of neuro-regenerative therapies based on increasing neurotrophins in the nervous system." Lecture in the school "Emmanuel College. 5th October, 2011.

Organization of a microscopy course in Regenerative Biology for teenager students. (Millennium Science Initiative). November 26th - Dec-11th, 2012.

Participation in Video “Women: protagonist of science. Girls of today, scientific of tomorrow”. Released November 21th, 2012 in Room Theater Level 2 Centro Cultural Palacio La Moneda Organized by CONICYT Program "SCIENCE change our life"

Interview Radio Universidad de Chile. Topic: research performed at the Millenium Nucleus in Regnerative Biology. March 19th, 2012.

Interview electronic newspaper e.mol. Theme: Academy of Sciences Award. 1st June, 2012.

Participation in video for cable network TV a series of about the research performed in different labs. VidaConCiencia Millennium Scientific Initiative (ICM), 2013.

Interview Radio Universidad de Chile. Theme: Millennium Program. March 10, 2014. http://radio.uchile.cl/programas/milenio/vicky-quevedo-converso-con-denise-saint-jean-directora-del-programa-formacion-de-capital-humano-avanzado-de-conicyt-sobre-los-concursos-destinados-a-profesionales-de-excelencia-que-buscan-perfecci

Interview Radio Universidad de Chile. Theme: Millennium Program. November 16, 2015.

Organization of a Regenerative Biology Microscopy Workshop for Middle School Students. Organized with funds of the Millennium Science Initiative. June 30-July 9 2015

Article published in “El Mostrador” 14th April 2016 (an electronic newspaper) about the reserch performed in Bronfman´lab related to stroke. Link:http://www.elmostrador.cl/noticias/vida-en-linea/2016/04/14/investigan-uso-de-antidepresivo-como-terapia-en-infartos-cerebrales/

Article published in “El Mercurio” one of the most influential newspapers in Chile. Page A9 section Life, Science and Technology. 28th April 2016. The article high-light the research performed in Bronfman lab related to stroke. Link:http://www.carechile.cl/es/el-mercurio-destaca-investigacion-de-dra-francisca-bronfman/.

Organization of a Regenerative Biology Microscopy Workshop for hight school students. Organized with funds of the Millennium Science Initiative. 21 November-7-December. 2016

Invited to participate in the Panel "Women in Sciences" within the framework of the Scientific Culture Day organized by the Andrés Bello University (UNAB). Gabriela Mistral Cultural Center (GAM), Santiago, Chile, November 29, 2017.

Radial Interview on Radio ADN "Agenda de Género", by Lucía López. December 14, 2017. http://www.adnradio.cl/noticias/sociedad/sabado-23-de-diciembre-conversamos-de-mujeres-en-el-futbol-con-belen-carvajal-y-monica-ledezma /20171226/nota/3674632.aspx. In the STEM Women's space we met the neurobiologist Francisca Bronfman, former director of the Millennium Nucleus in Regenerative Biology and Virginia Garretón, director of the Millennium Initiative, they talked about what it is to be a woman leader in the sciences.

As President of the Chilean Society for Cell Biology, I participated in the organization together with the Allende-Conelly Foundation of a “Latin American Workshop of Cell Biology” to generate a module of Cell Biology for secondary education that was held at the Central House of the University of Chile during November 26-27th, 2018.

RESEARCH PROJECTS.

Title of Research
Project responsible (*) and co - researchers
Funding agency
Duration (start year and end year)

Retrograde signaling by the neurotrophin receptor p75 and its relevance for the regeneration of cholinergic neurons.
Francisca Bronfman *
Fundación Andes
July 2003-July 2005
(2 years)

FONDECYT 1040799. Signaling mechanisms and cellular compartmentalization of signaling by p75 neurotrophin receptor.
Francisca Bronfman*
CONICYT
March 2004-March 2008
(4 years)

Bilateral cooperation project between Chile and Flanders " Cell Biology of APP processing and and its cross talk with the neurotrophic signaling " (Neuronal cell biology of APP processing and the cross talk with neurotrophic factor signaling)
Francisca Bronfman (Chile) * Willem Annaert (Belgium)
Flemish Community of Belgium. International Coopercaión
January 2004 -January 2006

ARA Project "Signaling pathways leading to neuronal death in NPC".
Silvana Zanlungo *, Alejandra Alvarez, y Francisca Bronfman
Ara Parseghian Medical Research Foundation.
July 2005-July 2007

Center for Cell Regulation and Pathology. FONDAP 13980001 2003-2008
Nibaldo Inestrosa* Francisca Bronfman
CONICYT
January 2005-January 2010
?
(5 years)

FONDECYT 1085273 "Contribution of endocytosis and proteolytic processing to neurotrophic signaling: crosstalk with Reelina/ApoER2 system "
Francisca Bronfman* María Paz Marzolo
CONICYT
March 2008-March 2012
FONDECYT 1070377 "Glia -to- axon transfer of ribosomes: Pathways and regulatory mechanisms"
Felipe Court* Jaime Alvarez y Francisca Bronfman
CONICYT
March 2007-March 2010

Basal program for scientific and technological centers of excellence "CENTER OF AGING AND REGENERATION" (CARE) Funding
Nibaldo Inestrosa * , Francisca Bronfman (Principal Investigator)
CONICYT
April 2008-2013.

Millennium Nucleus in Regenerative Biology (MINREB )
Maria Paz Marzolo* Francisca Bronfman (Pricipal Investigator)
ICM (Millenium Scientific Inniciative)
November 2009-November 2016.

FONDEF D0811031 Botanical Drugs for the treatment of insulin resistance and Type II Diabetes and its evaluation in the prevention of neurodegenerative diseases.
Miguel Bronfman*, Felipe Court, Francisca Bronfman (co-researches)
FONDEF
February2010-February 2013

FONDECYT 1120512 The synaptic c-Abl kinase regulates synaptic plasticity in adult brain. Its deregulation is involved in synaptic loss in alzheimer disease"
Alejandra Alvarez*, Francisca Bronfman y Briggitte Van Zundert (co-researches).
CONICYT

FONDECYT 1120146 "Role of Endocytic Rab GTPases in
Neurotrophin Signaling and Neuronal responses"
Francisca Bronfman*, Christian Gonzalez-Billault y Briggitte Van Zundert (co-researches)
CONICYT
March 2012-March 2016
(4 years)

Grant for outreach activities (PME) "Microcopy Laboratory for Regenerative Biology "
Francisca Bronfman *
ICM (Millenium Scientific Inniciative)
2012(1 año)

FONDECYT (1130321)
“Role of Wnt Signaling During the maturation of the neuromuscular junction”.
Juan Pablo Henriquez * Francisca Bronfman y Nelson Osses (co-researchers)
CONICYT
2012-2016
-
Basal program for scientific and technological centers of excellence “CENTER OF AGING AND REGENERATION (CARE) Funding”
Nibaldo Inestrosa*
Francisca Bronfman (Principal Investigator)
CONICYT
April 2013-2018.

Grant for Outreach activities (PME) "Microscopy Laboratory for Regenerative Biology"
Francisca Bronfman*
ICM (Millenium Scientific Inniciative)
December 2014-december 2015

Grant for Outreach activities (PME) "Microscopy Laboratory for Regenerative Biology"
Francisca Bronfman*
ICM (Millenium Scientific Inniciative)
December 2015-December 2016

Fondecyt (1171137), Elucidating the mechanism of long-distance control of dendritic growth by BDNF/TrkB signaling endosomes. Role of CREB and PPARgamma transcription factors. 2017-2020
Francisca Bronfman*
CONICYT
2017-2021

FONDEFidea (ID16I10185)
Development of a Nutraceutical Formulation derived from a Botanical extract with Neuroplastic and Neuroprotective Activities.
Francisca Bronfman* and Karen Fuenzalida (co-researcher)
CONICYT
2017-2019

IFAN Technology Consortium. Synergistic Development of Functional Ingredients and Natural Additives. P19. Lipid extracts derived from Algae. 2016-2022 16PTECAI-66648.
Francisca Bronfman* and Loretto Contreras, Alejandro Godoy and Nibaldo Inestrosa
CORFO
2016-2022.


Premios y Distinciones

  •   Scholarship DIPUC

    PONTIFICIA UNIVERSIDAD CATOLICA CAMPINAS

    Chile, 1994

    Scholarship DIPUC ( Directorate of Research and Graduate Pontifical Catholic University of Chile) research residency (Dr Nibaldo Inestrosa )

  •   CONICYT Scholarship for graduate students

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1995

    CONICYT Scholarship for graduate students (1995-1996)

  •   Scholarship for doctoral studies

    Flemish Community of Belgium. International Cooperation

    Bélgica, 1996

    Scholarship for doctoral studies of the Flemish Community of Belgium ( 1996-1997).

  •   Scholarship for PhD students

    KUL (Catholic University of Leuven)

    Bélgica, 1997

    Scholarship for PhD students of the Catholic University of Leuven , Belgium

  •   Scholarship for postgraduate research EMBO (short - term)

    EMBO

    Alemania, 2000

    Scholarship for postgraduate research EMBO (short - term) , Max Plank Institute for Biological Chemistry (Dr. Tom Jovin)

  •   Fainberg Postdoctoral Fellowship

    Weizmann Institute of Science

    Israel, 2000

    Fainberg Postdoctoral Fellowship at the Weizmann Institute of Science (October 2000 - January 2003).

  •   Excellence Award in Research

    Chileam Academy of Sciences

    Chile, 2012

    Premio a la trayectoria destacada Investigadora Joven


 

Article (48)

Long-distance regressive signaling in neural development and disease
An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
Long-distance regressive signaling in neural development and disease.
Long‐distance regressive signaling in neural development and disease
The Rab5-Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons
c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis
Brain-derived neurotrophic factor (BDNF) regulates Rab5-positive early endosomes in hippocampal neurons to induce dendritic branching
Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150(Glued) Deacetylation by Axonal HDAC1
Axonal PPARgamma promotes neuronal regeneration after injury.
Venlafaxine treatment after endothelin-1-induced cortical stroke modulates growth factor expression, reduces tissue damage and increases functional recovery in rats.
Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor (BDNF)
Neurodegeneration and Alzheimer´s Disease. What can proteomics tells us about Alzheimer´s brain?
Neurodegneration and Alzheimer´s Disease (AD). What can proteomic tell us about the Alzheimer´s Brain?
Rab GTPase signaling in neurite outgrowth and axon specification
Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B
Spatiotemporal intracellular dynamics of neurotrophin and its receptors. Implications for neurotrophin signaling and neuronal function
Sprouting of axonal collaterals after spinal cord injury is prevented by delayed axonal degeneration
Metalloproteinase-Dependent TLR2 Ectodomain Shedding is Involved in Soluble Toll-Like Receptor 2 (sTLR2) Production
Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway
p75 neurotrophin receptor evades the endolysosomal route, favoring multivesicular bodies specialized for exosomal release in neuronal cells
Sprouting of axonal collaterals after spinal cord injury is prevented by delayed axonal degeneration
The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release
BDNF Regulates Rab11-Mediated Recycling Endosome Dynamics to Induce Dendritic Branching
Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease
An Agonistic mAb Directed to the TrkC Receptor Juxtamembrane Region Defines a Trophic Hot Spot and Interactions with p75 Coreceptors
Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons
p75 Neurotrophin Receptor-mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up-regulation of Tumor Necrosis Factor-alpha-converting Enzyme/ADAM17
Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease
Antagonistic effects of TrkB and p75(NTR) on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes
ApoER2 expression increases A beta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity
Membrane bound carboxyterminal fragments of p75 neurotrophin receptor are generated by the activation of TrkA and internalized to endosomes for γ-secretase mediated processing
Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?
TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain
Peroxisome proliferator-activated receptor gamma is a novel target of the nerve growth factor signaling pathway in PC12 cells
Multi-tasking by the p75 neurotrophin receptor: sortilin things out?
Evaluation of 18F-FA-4 and 11C-pipzA-4 as radioligands for the in vivo evaluation of the high-affinity choline uptake system.
Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome
The p75 neurotrophin receptor interacts with multiple MAGE proteins.
Acetylcholinesterase-Positive Fiber Deafferentation and Cell Shrinkage in the Septohippocampal Pathway of Aged Amyloid Precursor Protein London Mutant Transgenic Mice
No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice
Prominent Axonopathy and Disruption of Axonal Transport in Transgenic Mice Expressing Human Apolipoprotein E4 in Neurons of Brain and Spinal Cord
Laminin blocks the assembly of wild-type A? and the Dutch variant peptide into Alzheimer's fibrils
Amyloid precursor protein fragment and acetylcholinesterase increase with cell confluence and differentiation in a neuronal cell line
Extracellular matrix regulates the amount of the ?-amyloid precursor protein and its amyloidogenic fragments
Laminin inhibits amyloid-β-peptide fibrillation
Acetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid-?-peptides

Abstract (1)

p75 neurotrophin receptor processing and trafficking in neuronal endosomes. New clues for p75 neuronal signaling

ConferencePaper (9)

Retrograde axonal signaling by BDNF promotes denditric branching in a Dynein-dependent manner
The non-receptor tyrosine kinase c-Abl participates in the signaling pathway BDNF/TrkB affecting dendritic branching.
Axonal BDNF promotes local synthesis and retrograde transport of the transcription factor PPARgamma in an mTOR depdent manner
PPARgamma function in the nervous system and a molecular target for natural drugs inducing neuroprotection
Reciprocal regulation of neurotrophin signaling and endosomal Rab GTPases to increase dendritic branching. From dendrites to the nucleus
c-Jun N-terminal kinase regulates p75 internalization leading to retrograde axonal transport of apoptotic signaling endosomes
Contribution of the endocytic pathway to BDNF-induced dendritic branching and signalling”
Death signaling endosomes in neuronal axons containing the common neurotrophin receptor. Implication for neurodegenerative diseases.
Role of the endocytic system in BDNF-mediated dendritic branching

ConferencePoster (21)

Activity of Monomeric GTPases Rab5 and Rab11 is increased by BDNF stimulation in cortical neurons
Axonal secretory processing and export of L1CAM in CNS neurons
Retrograde axonal signaling induced by BDNF triggers dendritic arborization in cortical neurons
BDNF regulates Rab5 and Rab11 monomeric GTPase activity and dynamics to induce dendritic growth
BDNF regulates Rab5 and Rab11 monomeric GTPase activity and dynamics to induce dendritic growth.
Rab35 functions in axon elongation are regulated by p53-relatedprotein kinase (PRPK) in a mechanism that involves Rab35 proteindegradation and the microtubule-associated protein 1B
The neurotrophin co-receptor p75 is required for neuromuscular junction maturation
The non-receptor tyrosine kinase c-Abl modulates the post-endocytic trafficking of the TrkB receptor affecting BDNF-induced dendritic branching
BDNF increases axonal PPAR gamma expression via the mTOR signaling pathway. Role in axonal growth.
BDNF increases the mRNA, protein levels, activity and movement of Rab5 in hippocampal neurons
BDNF requires the activity of Rab5-Rab11 GTPases to induce changes through the MAPK pathway in dendritic branching, CREB activation and immediate-early gene (IEGs) expression in hippocampal neurons.
c-Abl is involved in the BDNF/TrkB signaling pathway, promoting dendritic arborization in hippocampal neurons.
c-Abl participates in the BDNF/TrkB signaling pathway, regulating the availability of the TrkB receptor in the surface and promoting dendritic arborization in hippocampal neurons.
Rab5 mRNA, protein levels, movement and activity in hippocampal neurons stimulated with BDNF.
Rab5 activity is required for p75 apoptotic signaling in response to BDNF
The p75NTR neurotrophin receptor regulates the maintenance of the neuromuscular junction.
The Rab5-Rab11 endosomes are required for BDNF-induced dendritic branching and activation of CREB transcription factor in hippocampal neurons.
Intracellular Signaling by the P75 Neurotrophin Receptor.
PPARgamma is upregulates in axons after injury and promotes regeneration in peripheral and central neurons.
PPARy is upregulated in axons after injury and promotes regeneration in both peripheral and central neurons.
Rab5 positively modulates p75 apoptotic signaling.

ConferenceProceedingWhole (9)

How do neurons control their morphology? Role of Neurotrophins in protein translation and endosomal transport
How do neurons regulate their morphology? Role of neurotrophins in protein translation and transport of endosomes
Neurotrophins regulate the endosomal system and local translation of proteins for transcriptional control of dendritic growth
“BDNF regulates the endocytic system allowing the trabnscriptional control of dendritic growth”
Contribution of the endocytic pathway to BDNF-induced dendritic branching and nuclear signaling
Contribution of the endocytic system to BDNF-induced dendritic branching and signaling
Stroke and neuronal plasticity; importance for efective therapies
Contribution of the endocytic pathway to BDNF induced dendritic branching
Role of recycling endosomes in signaling and dendritic arborization induced by BDNF. From dendrites to the nucleus?

EditorialMaterial (1)

Commuting within the cell - Mind the GAPs workshop on systems dynamics of intracellular communication: Overcoming distance in signalling networks

Patent (1)

PCT International Application. Method for preparing an oleoresin from red algae, which maintains the ability to induce the transcriptional activity of nuclear receptor PPARgamma.

Proyecto (50)

Basal Center of excellence in Science and Technology CARE
Development of a Nutraceutical Formulation derived from a Botanical extract with Neuroplastic and Neuroprotective Activities
Elucidating the mechanism of long-distance control of dendritic growth by BDNF/TrkB signaling endosomes. Role of CREB and PPARgamma transcription factors
ELUCIDATING THE MECHANISM OF LONG-DISTANCE CONTROL OF DENDRITIC GROWTH BY BDNF/TRKB SIGNALING ENDOSOMES. ROLE OF CREB AND PPARGAMMA TRANSCRIPTION FACTORS.
PME=> "Laboratorio de biología regenerativa 2016"
Synergistic Development of Functional Ingredients and natural additives. P19. Lipid extracts derived from Algae
Núcleo Milenio en Biología Regenerativa (MINREB)
PME=> Laboratorio de microscopía=>" Biología Regenerativa" 2015
Caracterización de la acción anti-inflamatoria y neuromoduladora de la combinación entre Grasilex y Venlafaxina para la promoción de la recuperación motora en ratas
Centro de Envejecimiento y Regeneración CARE.
Las GTPasas Rabs regulan el crecimiento y regeneración del axón inducido por BDNF, a través del control de la localización y tráfico post-endocítico del receptor TrkB
Participación del factor de transcripción PPARgamma en la respuesta a daño axonal mediada por mTOR en neuronas del Sistema Nervioso Central
Laboratorio Itinerante de Biología Regenerativa
ROLE OF ENDOCYTIC RAB GTPASES IN NEUROTROPHIN SIGNALING AND NEURONAL RESPONSES
Role of Endocytic Rab GTPases in Neurotrophin Signaling and Neuronal responses
Role of Wnt Signaling During the maturation of the neuromuscular junction
Role of Wnt Signaling During the maturation of the neuromuscular junction
The synaptic c-Abl kinase regulates synaptic plasticity in adult brain. Its deregulation is involved in synaptic loss in alzheimer disease
Desarrollo de una droga combinada de Rosiglitazona y extracto de alga chilena edible para terapia neuroprotectora en infarto cerebral y otras enfermedades neurodegenerativas
Droga Botánica para el tratamiento de Resistencia a insulina y Diabetes tipo II y su evaluación en la prevención de enfermedades neurodegenerativas
Núcleo Milenio en Biología Regenerativa (MINREB)
Rol de la ruta endosoma en la regeneración axonal inducida por neurotrofinas
CENTRO DE ENVEJECIMIENTO Y REGENERACION” (CARE)
Contribución de la endocitosis y el procesamiento proteolitico a la señalización neurotrófica=> conversación cruzada con el sistema Reelina/ApoER2
Glia-to-axon transfer of ribosomes=> Pathways and regulatory mechanisms
ARA Project "Signaling pathways leading to neuronal death in NPC"
BDNF favors the recruitment of PI3K in early endosomes to regulate the transport of BDNF / TrkB signaling endosomes from axons to contribute to the dendritic arborization of cortical neurons
Bilateral cooperation project between Chile and Flanders " Cell Biology of APP processing and and its cross talk with the neurotrophic signaling " (Neuronal cell biology of APP processing and the cross talk with neurotrophic factor signaling)
Botanical Drugs for the treatment of insulin resistance and Type II Diabetes and its evaluation in the prevention of neurodegenerative diseases.
Center for Cell Regulation and Pathology. FONDAP 13980001 2003-2008
CENTER OF AGING AND REGENERATION
CENTER OF AGING AND REGENERATION (CARE)
Characterization of the anti - inflammatory and neuromodulator combination between Grasilex and Venlafaxine for promoting motor recovery in rats
Contribution of endocytosis and proteolytic processing to neurotrophic signaling : crosstalk with Reelina/ApoER2 system
Development of a combined neuroprotective therapy drug, consisting on Rosiglitazone and Chilean edible seaweed extract, for stroke and other neurodegenerative diseases
Functional role of internalization and post- endocytic trafficking of the p75 neurotrophin receptor
Glia -to- axon transfer of ribosomes: Pathways and regulatory mechanisms
Internalization and post- endocytic trafficking of TrkB as determinants in the functional response to BDNF in neurons
Microcopy Laboratory for Regenerative Biology
Microscopy Laboratory for Regenerative Biology
Millennium Nucleus in Regenerative Biology
Millennium Nucleus in Regenerative Biology Renewal
Participation of PPARy transcription factor in response to mTOR mediated axonal damage in neurons of the central nervous system
Rab GTPases regulate axon growth and regeneration induced by BDNF, through control of the localization and post- endocytic trafficking of TrkB receptor
Retrograde signaling by the neurotrophin receptor p75 and its relevance for the regeneration of cholinergic neurons.
Rol of the endocytic system in the apoptotic signaling mediated by p75 neurotrophin receptor in sympathetic neurons
Role of Endocytic Rab GTPases in Neurotrophin Signaling and Neuronal responses
Role of endosome route in neurotrophin -induced axonal regeneration
Signaling mechanisms and cellular compartmentalization of signaling by p75 neurotrophin receptor.
The synaptic c-Abl kinase regulates synaptic plasticity in adult brain. Its deregulation is involved in synaptic loss in alzheimer disease

Review (1)

Endosomal transport of neurotrophins: Roles in signaling and neurodegenerative diseases
114
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

5
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

5
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

3
Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

3
Jose Parraguez

Investigador

Particular

Santiago, Chile

3
Patricio Ramos

academico

Instituto de ciencias biológicas

UNIVERSIDAD DE TALCA

Talca, Chile

3
Mauricio Sandoval

Lab Manager

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

2
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

2
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

2
Oscar Lazo

Research Fellow

UK Dementia Research Institute and Department of Neuromuscular diseases

UCL Queen Square Institute of Neurology

London, Reino Unido

1
Maria Lisbona

Postdoctorado

Biología

Universidad de Chile

Santiago, Chile

1
David Diaz

Asistente de Investigación

Instituto de Ciencias Biomédicas, Facultad de Medicina

Universidad de Chile

Santiago, Chile

1
Daniel Henriquez

Director Ciencia Transversal

Fundación Centro MERI

Santiago, Chile

1
Valentina Valenzuela

Investigador adjunto

Universidad de Concepcion

Concepción, Chile

1
Marjorie De la Fuente

Investigadora Clinica

Direccion Academica

Clinica Las Condes

Santiago , Chile

1
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

1
David Contador

Universidad del Desarrollo

Santiago, Chile

1
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Quera

Gastroenterólogo

Gastroenterología

CLÍNICA LAS CONDES, SERVICIO DE GASTROENTEROLOGÍA

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
ignacio jausoro

POSTDOC

BIOLOGIA CELULAR Y MOLECULAR

PONTIFICIA UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Alejandra Catenaccio

Asistente de Investigación

Universidad Mayor

HUECHURABA, SANTIAGO, Chile

1
Maria Barria

Assistant Professor

Departamento de Microbiologia

Universidad de Concepción

CONCEPCION, Chile

1
Gonzalo Cancino

Assistant Professor

Facultad de Ciencias

Universidad Mayor

Santiago, Chile

1
Karen Fuenzalida

Encargado de confirmación diagnóstica de Errores Innatos del Metabolismo (EIM) mediante técnicas GCMS y LCMSMS

Instituto de Nutrición y Tecnología de Alimentos

Universidad de Chile

Santiago, Chile

1
Julio Amigo

Assistant Professor

Physiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Natalia Salvadores

investigador postdoctoral

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
Paula Diaz

PhD (c)

Departamento de Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

1
Viviana Pérez

Investigador Postdoctoral

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Rodrigo Sandoval

Director de departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
David Contador

Professor Instructor

School of Medicine

Universidad del Desarrollo

Santiago, Chile