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Johanna Patricia Ábrigo León

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

Líneas de Investigación


- Estudio de mecanismos y vías de señalización involucradas en el desarrollo de atrofia muscular esquelética producto de enfermedades crónicas en modelos in vivo e in vitro. - Expresión, purificación y análisis termodinámicos de proteínas.

Educación

  •  Biociencias Moleculares, UNIVERSIDAD ANDRES BELLO. Chile, 2019

Experiencia Profesional

  •   Investigador post-doctoral Part Time

    Centro Interdisciplinario de Neurociencia de Valparaíso

    Valparaíso-Santiago, Chile

    2020 - A la fecha

Premios y Distinciones

  •   Mejor tesis doctoral

    UNIVERSIDAD ANDRES BELLO

    Chile, 2019

    Premio a la mejor tesis doctoral año 2019, considerando publicaciones y logros obtenidos durante el desarrollo de la tesis.


 

Article (22)

Angiotensin (1-7) decreases myostatin-induced NF-kb signaling and skeletal muscle atrophy
N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease
Mitochondrial Dysfunction in Skeletal Muscle Pathologies
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia
Sarcopenia in a mice model of chronic liver disease=> Role of the ubiquitin-proteasome system and oxidative stress.
Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease: Beneficial Hepatic and Systemic Effects of Hormone Supplementation
TGF-ß requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy.
Central role of Transforming Growth Factor Type Beta 1 in skeletal muscle dysfunctions=> an update on therapeutic strategies.
The complex of PAMAM-OH dendrimer with Angiotensin (1-7) prevented the disuse-induced skeletal muscle atrophy in mice
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas
High fat diet-induced skeletal muscle wasting is decreased by mesenchymal stem cells administration=> implications on oxidative stress, ubiquitin proteasome pathway activation, and myonuclear apoptosis.
New formulation based on anti-atrophic peptides and dendrimers for skeletal muscle atrophy treatment.
Transforming growth factor type beta (TGF-?) requires reactive oxygen species to induce skeletal muscle atrophy
Angiotensin-(1-7) attenuates disuse-induced skeletal muscle atrophy via the Mas receptor
Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism
Apocynin inhibits the upregulation of TGF-beta(1) expression and ROS production induced by TGF-beta in skeletal muscle cells
The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice
Transforming growth factor type beta (TGF-b) requires reactive oxygen species to induce skeletal muscle atrophy
Expression of the Mas receptor is upregulated in skeletal muscle wasting
The Ang-(1-7)/Mas-1 axis attenuates the expression and signalling of TGF-beta 1 induced by AngII in mouse skeletal muscle
The Ang-(1–7)/Mas-1 axis attenuates the expression and signalling of TGF-beta1 induced by AngII in mouse skeletal muscle

Abstract (1)

Transforming growth factor type beta 1 (TGF-beta 1) induces skeletal muscle atrophy by a mechanism dependent of NADPH oxidase-induced reactive oxygen species.

Proyecto (5)

Role of Renin angiotensin system in myogenesis and muscle regeneration=> new combined therapeutic strategies based in nanomedicine for muscular dystrophies
Mechanisms involved in the cachexia induced by chronic liver diseases
Effects of Angiotensin 1-7 in Cell Death by Apoptosis on Angiotensin II-induced Skeletal Muscle Atrophy
Role of Angiotensin 1-7 on skeletal muscle wasting
Anti-atrophic role of angiotensin 1-7 on skeletal muscle
15
Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

9
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

9
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

5
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

3
Juan Rivera

Investigador

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

3
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Cristian Vilos

Profesor Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

2
Yaneisi Vazquez

Directora técnica de proyectos

Genética Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

1
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Viviana Pérez

Investigador Postdoctoral

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

1
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

1
Alvaro Elorza

ASSOCIATE PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
María Acuña

Directora de Investigación, académico e investigador

Universidad Bernardo O´Higgins

Santiago, Chile

1
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Nicolas Pacheco

PROFESOR ADJUNTO

CIENCIAS BIOLOGICAS

Universidad Andrés Bello

Santiago centro, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile