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Daniel Alejandro Cabrera Garcia

Investigador Adjunto

Pontificia Universidad Catolica de Chile

santiago, Chile

Líneas de Investigación


Hepatologia; Fisiopatologia Musculo-esqueletica; Diferenciacion celular

Educación

  •  Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
  •  Doctor en Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
  •  Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007

Experiencia Académica

  •   Profesor Asistente Part Time

    UNIVERSIDAD BERNARDO O'HIGGINS

    Salud

    Santiago, Chile

    2011 - A la fecha

  •   Docente Part Time

    UNIVERSIDAD DIEGO PORTALES

    Salud

    Santiago, Chile

    2010 - 2011

  •   Docente a cargo del curso "La guerra de los priones". Part Time

    PENTA-UC

    Santiago, Chile

    2011 - 2012

  •   Docente a cargo del curso "Fuerza y movimiento: Biología celular y molecular del músculo esquelético". Part Time

    PENTA-UC

    Santiago, Chile

    2010 - 2011

  •   Instructor curso Biologìa Celular Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2008 - 2009

  •   Ayudante del curso "Metabolismo". Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2004 - 2006

  •   Ayudante del curso "Genetica Molecular Avanzada". Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2004 - 2006

  •   Investigador adjunto Part Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Postdoctorado Full Time

    Pontificia Universidad Catolica de Chile

    Chile

    2013 - 2015

  •   Profesor asistente Part Time

    Universidad Bernardo O´Higgins

    Chile

    2013 - A la fecha

  •   Docente a cargo del curso "La guerra de los priones". Part Time

    PENTA-UC

    Santiago, Chile

    2011 - 2012

  •   Docente a cargo del curso "Fuerza y movimiento: Biología celular y molecular del músculo esquelético". Part Time

    PENTA-UC

    Santiago, Chile

    2010 - 2011

  •   Instructor del curso "Biología Celular". Part Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2008 - 2009

  •   Ayudante del curso "Genética Molecular Avanzada". Part Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2004 - 2006

  •   Ayudante del curso "Metabolismo". P Part Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2004 - 2006

  •   Investigador adjunto Part Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2017 - A la fecha

Formación de Capital Humano


Tesis postitulo en Medicina interna sub especialidad Gastroenterologia:

- Dr. Alex Ruiz (2015)
- Dr. Ricardo Cruz (2016)
- Dr. Diego San MArtin (2017)
- Dr. Rodrigo Cruz (2017)

Tesis Lic. En Biologia:

- Srta. Pamela Rojas de Santiago (2015).


Difusión y Transferencia


Patentamiento:

Daniel Cabrera, Jaime GUTIERREZ, Gabriela Morales, Claudio CABELLO-VERRUGIO, Juan Hancke y Enrique Brandan. Pharmaco-cellular therapeutic method for the treatment of muscular dystrophies. US20140271573 A1. US 14/213,403. (http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1=20140271573.PGNR.)

Difusion programa Explora-Conicyt:

2009 charla “Cuerpo y movimiento” en el Liceo Nuestra Señora de la Mercedes y Colegio Alma Mater.
2012 charla “Daño y regeneración celular” y “Uso de una droga botánica para el tratamiento de la distrofia muscular de Duchenne” en el Liceo N°1 Javiera Carrera
2019 Programa Pasantías Científicas Escolares “Protagonistas de la Ciencia 2019” con alumnos del Colegio Santa María Goretti, proyecto "Señalización paracrina en modelos in vitro de enfermedad de Hígado graso no alcohólico"


Premios y Distinciones

  •   Premio Padre Hurtado

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2001

    Premio Excelencia Académica

  •   Premio Mejor Tesis

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2007

    Premio a la mejor tesis en Ciencias Biológicas

  •   Premio COPEC-UC

    FUNDACION COPEC UNIVERSIDAD CATOLICA

    Chile, 2013

    Premio a la innovacion y al patentamiento

  •   1er seleccionado Pasantìa doctoral en el extranjero

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2012

    1er seleccionado Pasantìa doctoral en la UCLA de Estados Unidos

  •   Beca Presidente de la Republica

    Gobierno de Chile

    Chile, 2001

    Premios a la excelencia académica

  •   Beca Juan Gómez Millas

    MINEDUC

    Chile, 2001

    Beca excelencia Académica

  •   Beca CONICYT

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2007

    Beca CONICYT para estudios de Doctorado

  •   Postdoctorado FONDECYT

    FONDO NACIONAL DE CIENCIA,TECNOLOGIA E INNOVACION

    Chile, 2013

    Beca para formacion post doctoral


 

Article (40)

Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles
Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12
N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease
Intrahepatic fatty acids composition as a biomarker of NAFLD progression from steatosis to NASH by using H-1-MRS
Mitochondrial Dysfunction in Skeletal Muscle Pathologies
Dexmedetomidine metabolic clearance is not affected by fat mass in obese patients
Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is Associated with Higher Metabolism, Reduced Synaptic Plasticity and Cognitive Impairment in Octodon degus.
Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia.
Sarcopenia in a mice model of chronic liver disease=> role of the ubiquitin-proteasome system and oxidative stress.
Sarcopenia induction in a mouse model of chronic cholestatic liver disease: Role of the ubiquitin-proteasome system and oxidative stress
Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease=> Beneficial Hepatic and Systemic Effects of Hormone Supplementation.
TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy.
The pro-fibrotic connective tissue growth factor ( CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle
Transforming Growth Factor Beta Type I Role in Neurodegeneration=> Implications for Alzheimer´s Disease.
Triggering and resolution of inflammation in NASH.
Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis
Bile Acids in Cholestasis and its Treatment
TGF-b in HCC: When a friend Becomes an enemy?
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas
Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-beta) via Mas Receptor Activation
Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1.
High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis
Innate Immunity and Inflammation in NAFLD/NASH
Transforming growth factor type beta (TGF-?) requires reactive oxygen species to induce skeletal muscle atrophy
Apocynin inhibits the upregulation of TGF-beta(1) expression and ROS production induced by TGF-beta in skeletal muscle cells
Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis
NFkB inhibition by Andrographolide ameliorates inflammation and fibrogenesis through inflammasome substrate depletion in experimental Non-Alcoholic Steatohepatitis (NASH)
Renin‐Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle
ACE2 Is Augmented in Dystrophic Skeletal Muscle and Plays a Role in Decreasing Associated Fibrosis
Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis
Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells
Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy
Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling
Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2)
Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy
Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles
CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy
Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity
Constitutively activated dystrophic muscle fibroblasts show a paradoxical response to TGF-beta and CTGF/CCN2
Increase in decorin and biglycan in Duchenne Muscular Dystrophy: role of fibroblasts as cell source of these proteoglycans in the disease

Abstract (4)

NFkB inhibition by Andrographolide ameliorates inflammation and fibrogenesis through inflammasome substrate depletion in experimental Non-Alcoholic Steatohepatitis (NASH)
Role of Fcgamma receptors in experimental Non-Alcoholic Steatohepatitis
Diet-induced nonalcoholic fatty liver disease is associated with sarcopenia and decreased serum insulin growth factor-1
Effects of andrographolide in experimental non-alcoholic steatohepatitis

BookWhole (1)

UDCA, NorUDCA, and TUDCA in Liver Diseases: A Review of Their Mechanisms of Action and Clinical Applications

ConferencePaper (1)

Hepatic Fatty Acid Profile in Mice with Nonalcoholic Fatty Liver Disease Using Magnetic Resonance Spectroscopy

ConferencePoster (6)

NOVEL INSIGHTS INTO THE CROSSTALK BETWEEN MINERALOCORTICOID RECEPTOR AND EXTRACELLULAR VESICLES IN KUPFFER CELLS ACTIVATION IN NASH
Chemical Hypoxia Determines Extracellular Vesicles Release from Fat-Laden Hepatocytes and Cellular Crosstalk with Hepatic Stellate Cells
Extracellular Vesicles Release from Fat-Laden Hepatocytes activates Kupffer Cells through MR activation.
Inflammasome substrate depletion by Andrographolide improves Non-Alcoholic Steatohepatitis
Assessment of intestinal barrier function in mice with non-alcoholic fatty liver disease subjected to intermittent hypoxia
The hypoxia-mimetic agent CoCl2 induces proinflammatory and profibrotic signals as well as inflammasome activation in liver cells

EditorialMaterial (1)

Obeticholic acid: expanding the therapeutic landscape of NASH

Proyecto (34)

Bile acids and extracellular vesicles as novel biomarkers to stratify the severity of alcohol­related liver disease: from binge drinking to alcoholic hepatitis
RANTES, a new myokine, participates in the chronic liver disease-associated sarcopenia.
Assessing the role of bile acids (BA) in NASH-related hepatocellular carcinoma
Dissecting therapeutic role of Growth Hormone and Insulin-like Growth Factor 1 in chronic liver disease: balancing between hepatocyte protection and oncogenic potential
Role of Angiotensin 1-7 on skeletal muscle wasting
Searching for the missing link between hepatocyte injury and liver inflammation: The role of mineralocorticoid receptor in Kupffer cells activation
SEARCHING FOR THE MISSING LINK BETWEEN HEPATOCYTE INJURY AND LIVER INFLAMMATION=> THE ROLE OF MINERALOCORTICOID RECEPTOR IN KUPFFER CELLS ACTIVATION
MECHANISMS INVOLVED IN THE CACHEXIA INDUCED BY CHRONIC LIVER DISEASES
MECHANISMS INVOLVED IN THE CACHEXIA INDUCED BY CHRONIC LIVER DISEASES
Evaluating somatotropic axis dysregulation and protective role of growth hormone and insulin like growth factor 1 supplementation in non-alcoholic fatty liver disease
LIVER INJURY IN NON-ALCOHOLIC FATTY LIVER DISEASE=> EXPLORING NEW MODULATORS AND BIOMARKERS
LIVER INJURY IN NON-ALCOHOLIC FATTY LIVER DISEASE=> EXPLORING NEW MODULATORS AND BIOMARKERS
THE EFFECT OF OBESITY IN DEXMEDETOMIDINE METABOLIC CLEARANCE
THE EFFECT OF OBESITY IN DEXMEDETOMIDINE METABOLIC CLEARANCE
Centro de envejecimiento y regeneración
Angiotensina 1-7 modula la señalizacion dependiente del factor de crecimiento tipo insulinico 1 y el factor nuclear kappa b en un modelo de atrofia muscular esqueletica inducido por lipopolisacarido
Centro de Envejecimiento y Regeneración (CARE)
HEPATITIS C VIRUS EXPLOITS THE HEPATIC LIPID PATHWAYS=> ROLE OF NPC1L1 IN HCV INFECTION.
HEPATITIS C VIRUS EXPLOITS THE HEPATIC LIPID PATHWAYS=> ROLE OF NPC1L1 IN HCV INFECTION.
Hitting the brakes in the innate immune response=> synergic action of TGR5 and andrographolide in non-alcoholic steatohepatitis
Anti-atrophic role of angiotensin 1-7 on skeletal muscle
DROGA BOTÁNICA PARA EL PARA EL TRATAMIENTO DE LA FIBROSIS CARDÍACA
EXPLORING NEW PATHOPHYSIOLOGICAL PATHWAYS IN NONALCOHOLIC FATTY LIVER DISEASE
Novel antifibrotic role of the ace2/angiotensin 1-7/mas axis in skeletal muscular dystrophies
Reduced reck levels improve the muscle cell therapy and diminish the fibrosis associated to the dystrophic muscle
Centro de Envejecimiento y Regeneración (CARE)
CTGF the factor involved in fibrosis development in DMD
ENFERMEDAD RENAL CRONICA E HIPERTENSION ARTERIAL: PARTICIPACION DE CICLOOXIGENASA-2 Y ANGIOTENSINA 1-7
Profibrotic effect of the renin-angiotensin system and connective tissue growth factor (ctgf) in dystrophic skeletal muscle
DROGA BOTANICA (BOTANICAL DRUG PARA LA FDA DE EEUU) PARA EL TRATAMIENTO EN ENFERMEDADES CRONICAS ASO CIADAS A FIBROSIS DE ALTA INCIDENCIA NACIONAL Y MUNDIAL
Skeletal muscle formation, function and disease.
DMD fibrosis=> Role of CTGF, LRP and proteoglycans
Expresion de moleculas de superficie celular en distrofinopatia: mdx versus duchenne
Function of proteoglycans during skeletal muscle differentiation

Review (3)

Central role of transforming growth factor type beta 1 in skeletal muscle dysfunctions: An update on therapeutic strategies
Innate Immunity and Inflammation in NAFLD/NASH
Renin-Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle
61
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

19
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

14
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

11
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

5
Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

5
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

4
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

4
Juan Arab

Assistant Professor

Gastroenterologia

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

3
María Acuña

Directora de Investigación, académico e investigador

Universidad Bernardo O´Higgins

Santiago, Chile

3
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Aline Carvalho da Silva

PostDoc

Universidad de O'Higgins

Región de O'Higgins, Chile

2
Cristian Vilos

Profesor Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

2
Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

2
Flavia Zacconi

Associate Professor

Organic Chemistry

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

2
Juan Rivera

Investigador

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

2
Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

2
ricardo fadic

Jefe de Division

Division de Neurociencias

DEPARTAMENTO DE NEUROLOGÍA, FACULTAD DE MEDICINA, P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

1
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Sandra Solari

Profesor Asociado

Departamento Laboratorios Clinicos - Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Victor Contreras

Director y Gestor de Proyectos

Anestesiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Evelyn Jara

Docente/Investigador

Ciencias Básicas

Universidad Santo Tomás

Temuco, Chile

1
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

1
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

1
Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

1
Yaneisi Vazquez

Directora técnica de proyectos

Genética Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Marcelo Andia

Associate Professor

Radiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Sergio Mezzano

Catedratico

Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Alejandra Hernández

Investigador postdoctoral

Gastroenterología

CARE-Chile

Santiago, Chile

1
Luis Cortínez

DIVISIÓN DE ANESTESIOLOGÍA, ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carlos Sing-Long

Assistant Professor

Instituto de Ingeniería Matemática y Computacional

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

Santiago, Chile

1
Jose Ignacio Vargas

Assistant Professor

GASTROENTEROLOGY

Pontificia Universidad Católica de Chile

SANTIAGO, Chile